CD36 gene polymorphism is associated with Alzheimer's disease.
Identifieur interne : 000E73 ( PubMed/Corpus ); précédent : 000E72; suivant : 000E74CD36 gene polymorphism is associated with Alzheimer's disease.
Auteurs : Omar Šer ; Jana Janoutová ; Laura Ewerlingová ; Alice Hálová ; Jan Lochman ; Vladimír Janout ; Naim A. Khan ; Vladimir J. BalcarSource :
- Biochimie [ 1638-6183 ] ; 2017.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Antigens, CD36.
- genetics : Alzheimer Disease, Genetic Predisposition to Disease, Polymorphism, Genetic, Polymorphism, Single Nucleotide.
- metabolism : Alzheimer Disease, Cholesterol.
- Aged, Female, Genotype, Humans, Male, Oxidative Stress.
Abstract
CD36 gene encodes a membrane glycoprotein (type B scavenger receptor) present on the surface of many types of cells and having multiple cellular functions ranging from angiogenesis to gustatory perception of fatty acids. Using a case control genetic association approach we have analyzed selected single nucleotide polymorphisms (SNP's) in a total of 859 patients with Alzheimer's disease (AD) and controls and have identified the allele A in rs3211892 polymorphism of CD36 gene as significantly increasing the risk of AD. Additionally we have investigated, in the same sample of control subjects and patients, SNP's in ApoE gene and confirmed that the previously identified AD-associated SNP's indeed increased the risk and decreased the age of onset of AD as reported by others earlier. Based on the current knowledge of CD36 biochemistry we propose that the AD risk-imparting variants of CD36 alter cholesterol homeostasis, oxidation stress or induce pathological inflammatory cascades. The SNP rs3211892 has previously been associated with heart disease and other conditions but the present study is the first to identify a significant association between variations in CD36 gene and the risk of Alzheimer's disease.
DOI: 10.1016/j.biochi.2017.01.009
PubMed: 28111291
Links to Exploration step
pubmed:28111291Le document en format XML
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Electronic address: omarsery@sci.muni.cz.</nlm:affiliation></affiliation></author><author><name sortKey="Janoutova, Jana" sort="Janoutova, Jana" uniqKey="Janoutova J" first="Jana" last="Janoutová">Jana Janoutová</name><affiliation><nlm:affiliation>Department of Epidemiology and Public Health, Faculty of Medicine, University of Ostrava, Czechia.</nlm:affiliation></affiliation></author><author><name sortKey="Ewerlingova, Laura" sort="Ewerlingova, Laura" uniqKey="Ewerlingova L" first="Laura" last="Ewerlingová">Laura Ewerlingová</name><affiliation><nlm:affiliation>Laboratory of Neurobiology and Molecular Psychiatry, Department of Biochemistry, Faculty of Science, Masaryk University, Kotlářská 2, 611 37, Brno, Czechia; Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Veveří 97, 602 00, Brno, Czechia.</nlm:affiliation></affiliation></author><author><name sortKey="Halova, Alice" sort="Halova, Alice" uniqKey="Halova A" first="Alice" last="Hálová">Alice Hálová</name><affiliation><nlm:affiliation>Laboratory of Neurobiology and Molecular Psychiatry, Department of Biochemistry, Faculty of Science, Masaryk University, Kotlářská 2, 611 37, Brno, Czechia; Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Veveří 97, 602 00, Brno, Czechia.</nlm:affiliation></affiliation></author><author><name sortKey="Lochman, Jan" sort="Lochman, Jan" uniqKey="Lochman J" first="Jan" last="Lochman">Jan Lochman</name><affiliation><nlm:affiliation>Laboratory of Neurobiology and Molecular Psychiatry, Department of Biochemistry, Faculty of Science, Masaryk University, Kotlářská 2, 611 37, Brno, Czechia.</nlm:affiliation></affiliation></author><author><name sortKey="Janout, Vladimir" sort="Janout, Vladimir" uniqKey="Janout V" first="Vladimír" last="Janout">Vladimír Janout</name><affiliation><nlm:affiliation>Department of Epidemiology and Public Health, Faculty of Medicine, University of Ostrava, Czechia.</nlm:affiliation></affiliation></author><author><name sortKey="Khan, Naim A" sort="Khan, Naim A" uniqKey="Khan N" first="Naim A" last="Khan">Naim A. Khan</name><affiliation><nlm:affiliation>Physiologie de la Nutrition et Toxicologie, UMR U866 INSERM/Université de Bourgogne/Agro-Sup, 6, Boulevard Gabriel, Dijon, 21000, France.</nlm:affiliation></affiliation></author><author><name sortKey="Balcar, Vladimir J" sort="Balcar, Vladimir J" uniqKey="Balcar V" first="Vladimir J" last="Balcar">Vladimir J. Balcar</name><affiliation><nlm:affiliation>Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Veveří 97, 602 00, Brno, Czechia; Discipline Anatomy and Histology and Bosch Institute, School of Medical Sciences, Sydney Medical School, The University of Sydney, NSW, 2006, Australia.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28111291</idno><idno type="pmid">28111291</idno><idno type="doi">10.1016/j.biochi.2017.01.009</idno><idno type="wicri:Area/PubMed/Corpus">000E73</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000E73</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">CD36 gene polymorphism is associated with Alzheimer's disease.</title><author><name sortKey="Ser, Omar" sort="Ser, Omar" uniqKey="Ser O" first="Omar" last="Šer">Omar Šer</name><affiliation><nlm:affiliation>Laboratory of Neurobiology and Molecular Psychiatry, Department of Biochemistry, Faculty of Science, Masaryk University, Kotlářská 2, 611 37, Brno, Czechia; Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Veveří 97, 602 00, Brno, Czechia. Electronic address: omarsery@sci.muni.cz.</nlm:affiliation></affiliation></author><author><name sortKey="Janoutova, Jana" sort="Janoutova, Jana" uniqKey="Janoutova J" first="Jana" last="Janoutová">Jana Janoutová</name><affiliation><nlm:affiliation>Department of Epidemiology and Public Health, Faculty of Medicine, University of Ostrava, Czechia.</nlm:affiliation></affiliation></author><author><name sortKey="Ewerlingova, Laura" sort="Ewerlingova, Laura" uniqKey="Ewerlingova L" first="Laura" last="Ewerlingová">Laura Ewerlingová</name><affiliation><nlm:affiliation>Laboratory of Neurobiology and Molecular Psychiatry, Department of Biochemistry, Faculty of Science, Masaryk University, Kotlářská 2, 611 37, Brno, Czechia; Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Veveří 97, 602 00, Brno, Czechia.</nlm:affiliation></affiliation></author><author><name sortKey="Halova, Alice" sort="Halova, Alice" uniqKey="Halova A" first="Alice" last="Hálová">Alice Hálová</name><affiliation><nlm:affiliation>Laboratory of Neurobiology and Molecular Psychiatry, Department of Biochemistry, Faculty of Science, Masaryk University, Kotlářská 2, 611 37, Brno, Czechia; Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Veveří 97, 602 00, Brno, Czechia.</nlm:affiliation></affiliation></author><author><name sortKey="Lochman, Jan" sort="Lochman, Jan" uniqKey="Lochman J" first="Jan" last="Lochman">Jan Lochman</name><affiliation><nlm:affiliation>Laboratory of Neurobiology and Molecular Psychiatry, Department of Biochemistry, Faculty of Science, Masaryk University, Kotlářská 2, 611 37, Brno, Czechia.</nlm:affiliation></affiliation></author><author><name sortKey="Janout, Vladimir" sort="Janout, Vladimir" uniqKey="Janout V" first="Vladimír" last="Janout">Vladimír Janout</name><affiliation><nlm:affiliation>Department of Epidemiology and Public Health, Faculty of Medicine, University of Ostrava, Czechia.</nlm:affiliation></affiliation></author><author><name sortKey="Khan, Naim A" sort="Khan, Naim A" uniqKey="Khan N" first="Naim A" last="Khan">Naim A. Khan</name><affiliation><nlm:affiliation>Physiologie de la Nutrition et Toxicologie, UMR U866 INSERM/Université de Bourgogne/Agro-Sup, 6, Boulevard Gabriel, Dijon, 21000, France.</nlm:affiliation></affiliation></author><author><name sortKey="Balcar, Vladimir J" sort="Balcar, Vladimir J" uniqKey="Balcar V" first="Vladimir J" last="Balcar">Vladimir J. Balcar</name><affiliation><nlm:affiliation>Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Veveří 97, 602 00, Brno, Czechia; Discipline Anatomy and Histology and Bosch Institute, School of Medical Sciences, Sydney Medical School, The University of Sydney, NSW, 2006, Australia.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Biochimie</title><idno type="eISSN">1638-6183</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Alzheimer Disease (genetics)</term><term>Alzheimer Disease (metabolism)</term><term>Antigens, CD36 (genetics)</term><term>Cholesterol (metabolism)</term><term>Female</term><term>Genetic Predisposition to Disease (genetics)</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Oxidative Stress</term><term>Polymorphism, Genetic (genetics)</term><term>Polymorphism, Single Nucleotide (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Antigens, CD36</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Alzheimer Disease</term><term>Genetic Predisposition to Disease</term><term>Polymorphism, Genetic</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Alzheimer Disease</term><term>Cholesterol</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Oxidative Stress</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">CD36 gene encodes a membrane glycoprotein (type B scavenger receptor) present on the surface of many types of cells and having multiple cellular functions ranging from angiogenesis to gustatory perception of fatty acids. Using a case control genetic association approach we have analyzed selected single nucleotide polymorphisms (SNP's) in a total of 859 patients with Alzheimer's disease (AD) and controls and have identified the allele A in rs3211892 polymorphism of CD36 gene as significantly increasing the risk of AD. Additionally we have investigated, in the same sample of control subjects and patients, SNP's in ApoE gene and confirmed that the previously identified AD-associated SNP's indeed increased the risk and decreased the age of onset of AD as reported by others earlier. Based on the current knowledge of CD36 biochemistry we propose that the AD risk-imparting variants of CD36 alter cholesterol homeostasis, oxidation stress or induce pathological inflammatory cascades. The SNP rs3211892 has previously been associated with heart disease and other conditions but the present study is the first to identify a significant association between variations in CD36 gene and the risk of Alzheimer's disease.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28111291</PMID><DateCreated><Year>2017</Year><Month>01</Month><Day>23</Day></DateCreated><DateCompleted><Year>2017</Year><Month>03</Month><Day>21</Day></DateCompleted><DateRevised><Year>2017</Year><Month>11</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1638-6183</ISSN><JournalIssue CitedMedium="Internet"><Volume>135</Volume><PubDate><Year>2017</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Biochimie</Title><ISOAbbreviation>Biochimie</ISOAbbreviation></Journal><ArticleTitle>CD36 gene polymorphism is associated with Alzheimer's disease.</ArticleTitle><Pagination><MedlinePgn>46-53</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0300-9084(16)30366-2</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.biochi.2017.01.009</ELocationID><Abstract><AbstractText>CD36 gene encodes a membrane glycoprotein (type B scavenger receptor) present on the surface of many types of cells and having multiple cellular functions ranging from angiogenesis to gustatory perception of fatty acids. Using a case control genetic association approach we have analyzed selected single nucleotide polymorphisms (SNP's) in a total of 859 patients with Alzheimer's disease (AD) and controls and have identified the allele A in rs3211892 polymorphism of CD36 gene as significantly increasing the risk of AD. Additionally we have investigated, in the same sample of control subjects and patients, SNP's in ApoE gene and confirmed that the previously identified AD-associated SNP's indeed increased the risk and decreased the age of onset of AD as reported by others earlier. Based on the current knowledge of CD36 biochemistry we propose that the AD risk-imparting variants of CD36 alter cholesterol homeostasis, oxidation stress or induce pathological inflammatory cascades. The SNP rs3211892 has previously been associated with heart disease and other conditions but the present study is the first to identify a significant association between variations in CD36 gene and the risk of Alzheimer's disease.</AbstractText><CopyrightInformation>Copyright © 2017 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Šerý</LastName><ForeName>Omar</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Laboratory of Neurobiology and Molecular Psychiatry, Department of Biochemistry, Faculty of Science, Masaryk University, Kotlářská 2, 611 37, Brno, Czechia; Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Veveří 97, 602 00, Brno, Czechia. Electronic address: omarsery@sci.muni.cz.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Janoutová</LastName><ForeName>Jana</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Public Health, Faculty of Medicine, University of Ostrava, Czechia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ewerlingová</LastName><ForeName>Laura</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Laboratory of Neurobiology and Molecular Psychiatry, Department of Biochemistry, Faculty of Science, Masaryk University, Kotlářská 2, 611 37, Brno, Czechia; Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Veveří 97, 602 00, Brno, Czechia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hálová</LastName><ForeName>Alice</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Laboratory of Neurobiology and Molecular Psychiatry, Department of Biochemistry, Faculty of Science, Masaryk University, Kotlářská 2, 611 37, Brno, Czechia; Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Veveří 97, 602 00, Brno, Czechia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lochman</LastName><ForeName>Jan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Laboratory of Neurobiology and Molecular Psychiatry, Department of Biochemistry, Faculty of Science, Masaryk University, Kotlářská 2, 611 37, Brno, Czechia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Janout</LastName><ForeName>Vladimír</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Public Health, Faculty of Medicine, University of Ostrava, Czechia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khan</LastName><ForeName>Naim A</ForeName><Initials>NA</Initials><AffiliationInfo><Affiliation>Physiologie de la Nutrition et Toxicologie, UMR U866 INSERM/Université de Bourgogne/Agro-Sup, 6, Boulevard Gabriel, Dijon, 21000, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Balcar</LastName><ForeName>Vladimir J</ForeName><Initials>VJ</Initials><AffiliationInfo><Affiliation>Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Veveří 97, 602 00, Brno, Czechia; Discipline Anatomy and Histology and Bosch Institute, School of Medical Sciences, Sydney Medical School, The University of Sydney, NSW, 2006, Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>01</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>France</Country><MedlineTA>Biochimie</MedlineTA><NlmUniqueID>1264604</NlmUniqueID><ISSNLinking>0300-9084</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018955">Antigens, CD36</NameOfSubstance></Chemical><Chemical><RegistryNumber>97C5T2UQ7J</RegistryNumber><NameOfSubstance UI="D002784">Cholesterol</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000544" MajorTopicYN="N">Alzheimer Disease</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018955" MajorTopicYN="N">Antigens, CD36</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002784" MajorTopicYN="N">Cholesterol</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020022" MajorTopicYN="N">Genetic Predisposition to Disease</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005838" MajorTopicYN="N">Genotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018384" MajorTopicYN="N">Oxidative Stress</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011110" MajorTopicYN="N">Polymorphism, Genetic</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020641" MajorTopicYN="N">Polymorphism, Single Nucleotide</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">ApoE</Keyword><Keyword MajorTopicYN="N">Association</Keyword><Keyword MajorTopicYN="N">CD36</Keyword><Keyword MajorTopicYN="N">Gene</Keyword><Keyword MajorTopicYN="N">MMSE</Keyword><Keyword MajorTopicYN="N">Polymorphism</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>11</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>01</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>1</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>3</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>1</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28111291</ArticleId><ArticleId IdType="pii">S0300-9084(16)30366-2</ArticleId><ArticleId IdType="doi">10.1016/j.biochi.2017.01.009</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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