Exposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma: a nested case-control study.
Identifieur interne : 000E48 ( PubMed/Corpus ); précédent : 000E47; suivant : 000E49Exposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma: a nested case-control study.
Auteurs : Veronika Fedirko ; Hao Quang Tran ; Andrew T. Gewirtz ; Magdalena Stepien ; Antonia Trichopoulou ; Krasimira Aleksandrova ; Anja Olsen ; Anne Tj Nneland ; Kim Overvad ; Franck Carbonnel ; Marie-Christine Boutron-Ruault ; Gianluca Severi ; Tilman Kühn ; Rudolf Kaaks ; Heiner Boeing ; Christina Bamia ; Pagona Lagiou ; Sara Grioni ; Salvatore Panico ; Domenico Palli ; Rosario Tumino ; Alessio Naccarati ; Petra H. Peeters ; H B Bueno-De-Mesquita ; Elisabete Weiderpass ; José María Huerta Casta O ; Aurelio Barricarte ; María-José Sánchez ; Miren Dorronsoro ; J Ram N Quir S ; Antonio Agudo ; Klas Sjöberg ; Bodil Ohlsson ; Oskar Hemmingsson ; M Rten Werner ; Kathryn E. Bradbury ; Kay-Tee Khaw ; Nick Wareham ; Konstantinos K. Tsilidis ; Dagfinn Aune ; Augustin Scalbert ; Isabelle Romieu ; Elio Riboli ; Mazda JenabSource :
- BMC medicine [ 1741-7015 ] ; 2017.
English descriptors
- KwdEn :
- Adult, Aged, Carcinoma, Hepatocellular (blood), Carcinoma, Hepatocellular (immunology), Carcinoma, Hepatocellular (microbiology), Case-Control Studies, Cohort Studies, Female, Flagellin (immunology), Humans, Immunoglobulin A (blood), Immunoglobulin A (immunology), Immunoglobulin G (blood), Immunoglobulin G (immunology), Lipopolysaccharides (immunology), Liver Neoplasms (blood), Liver Neoplasms (immunology), Liver Neoplasms (microbiology), Male, Middle Aged, Prospective Studies, Risk Factors.
- MESH :
- chemical , blood : Immunoglobulin A, Immunoglobulin G.
- chemical , immunology : Flagellin, Immunoglobulin A, Immunoglobulin G, Lipopolysaccharides.
- blood : Carcinoma, Hepatocellular, Liver Neoplasms.
- immunology : Carcinoma, Hepatocellular, Liver Neoplasms.
- microbiology : Carcinoma, Hepatocellular, Liver Neoplasms.
- Adult, Aged, Case-Control Studies, Cohort Studies, Female, Humans, Male, Middle Aged, Prospective Studies, Risk Factors.
Abstract
Leakage of bacterial products across the gut barrier may play a role in liver diseases which often precede the development of liver cancer. However, human studies, particularly from prospective settings, are lacking.
DOI: 10.1186/s12916-017-0830-8
PubMed: 28372583
Links to Exploration step
pubmed:28372583Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Exposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma: a nested case-control study.</title><author><name sortKey="Fedirko, Veronika" sort="Fedirko, Veronika" uniqKey="Fedirko V" first="Veronika" last="Fedirko">Veronika Fedirko</name><affiliation><nlm:affiliation>Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA. vfedirk@emory.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Tran, Hao Quang" sort="Tran, Hao Quang" uniqKey="Tran H" first="Hao Quang" last="Tran">Hao Quang Tran</name><affiliation><nlm:affiliation>Center for Inflammation, Immunity, and Infection Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, 30303, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Gewirtz, Andrew T" sort="Gewirtz, Andrew T" uniqKey="Gewirtz A" first="Andrew T" last="Gewirtz">Andrew T. Gewirtz</name><affiliation><nlm:affiliation>Center for Inflammation, Immunity, and Infection Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, 30303, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Stepien, Magdalena" sort="Stepien, Magdalena" uniqKey="Stepien M" first="Magdalena" last="Stepien">Magdalena Stepien</name><affiliation><nlm:affiliation>Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Trichopoulou, Antonia" sort="Trichopoulou, Antonia" uniqKey="Trichopoulou A" first="Antonia" last="Trichopoulou">Antonia Trichopoulou</name><affiliation><nlm:affiliation>Hellenic Health Foundation, 13 Kaisareias Street, Athens, GR-115 27, Greece.</nlm:affiliation></affiliation></author><author><name sortKey="Aleksandrova, Krasimira" sort="Aleksandrova, Krasimira" uniqKey="Aleksandrova K" first="Krasimira" last="Aleksandrova">Krasimira Aleksandrova</name><affiliation><nlm:affiliation>Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nutrition, Immunity and Metabolism Start-up Lab, Nuthetal, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Olsen, Anja" sort="Olsen, Anja" uniqKey="Olsen A" first="Anja" last="Olsen">Anja Olsen</name><affiliation><nlm:affiliation>Danish Cancer Society Research Center, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Tj Nneland, Anne" sort="Tj Nneland, Anne" uniqKey="Tj Nneland A" first="Anne" last="Tj Nneland">Anne Tj Nneland</name><affiliation><nlm:affiliation>Danish Cancer Society Research Center, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Overvad, Kim" sort="Overvad, Kim" uniqKey="Overvad K" first="Kim" last="Overvad">Kim Overvad</name><affiliation><nlm:affiliation>Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Carbonnel, Franck" sort="Carbonnel, Franck" uniqKey="Carbonnel F" first="Franck" last="Carbonnel">Franck Carbonnel</name><affiliation><nlm:affiliation>Université Paris-Saclay, Université Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Boutron Ruault, Marie Christine" sort="Boutron Ruault, Marie Christine" uniqKey="Boutron Ruault M" first="Marie-Christine" last="Boutron-Ruault">Marie-Christine Boutron-Ruault</name><affiliation><nlm:affiliation>Université Paris-Saclay, Université Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:affiliation>Université Paris-Saclay, Université Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Kuhn, Tilman" sort="Kuhn, Tilman" uniqKey="Kuhn T" first="Tilman" last="Kühn">Tilman Kühn</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name><affiliation><nlm:affiliation>Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Bamia, Christina" sort="Bamia, Christina" uniqKey="Bamia C" first="Christina" last="Bamia">Christina Bamia</name><affiliation><nlm:affiliation>Hellenic Health Foundation, 13 Kaisareias Street, Athens, GR-115 27, Greece.</nlm:affiliation></affiliation></author><author><name sortKey="Lagiou, Pagona" sort="Lagiou, Pagona" uniqKey="Lagiou P" first="Pagona" last="Lagiou">Pagona Lagiou</name><affiliation><nlm:affiliation>Hellenic Health Foundation, 13 Kaisareias Street, Athens, GR-115 27, Greece.</nlm:affiliation></affiliation></author><author><name sortKey="Grioni, Sara" sort="Grioni, Sara" uniqKey="Grioni S" first="Sara" last="Grioni">Sara Grioni</name><affiliation><nlm:affiliation>Epidemiology and Prevention Unit Fondazione IRCCS Istituto Nazionale dei Tumori Via Venezian, 1 20133, Milano, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Panico, Salvatore" sort="Panico, Salvatore" uniqKey="Panico S" first="Salvatore" last="Panico">Salvatore Panico</name><affiliation><nlm:affiliation>Dipartimento di Medicina Clinica Echirurgia Federico II University, Naples, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Palli, Domenico" sort="Palli, Domenico" uniqKey="Palli D" first="Domenico" last="Palli">Domenico Palli</name><affiliation><nlm:affiliation>Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute - ISPO, Florence, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Tumino, Rosario" sort="Tumino, Rosario" uniqKey="Tumino R" first="Rosario" last="Tumino">Rosario Tumino</name><affiliation><nlm:affiliation>Cancer Registry and Histopathology Unit, "Civic -M.P. Arezzo" Hospital, ASP, Ragusa, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Naccarati, Alessio" sort="Naccarati, Alessio" uniqKey="Naccarati A" first="Alessio" last="Naccarati">Alessio Naccarati</name><affiliation><nlm:affiliation>Molecular and Genetic Epidemiology Unit, HuGeF, Human Genetics Foundation, Torino, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H" last="Peeters">Petra H. Peeters</name><affiliation><nlm:affiliation>Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Bueno De Mesquita, H B" sort="Bueno De Mesquita, H B" uniqKey="Bueno De Mesquita H" first="H B" last="Bueno-De-Mesquita">H B Bueno-De-Mesquita</name><affiliation><nlm:affiliation>Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name><affiliation><nlm:affiliation>Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Casta O, Jose Maria Huerta" sort="Casta O, Jose Maria Huerta" uniqKey="Casta O J" first="José María Huerta" last="Casta O">José María Huerta Casta O</name><affiliation><nlm:affiliation>Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Barricarte, Aurelio" sort="Barricarte, Aurelio" uniqKey="Barricarte A" first="Aurelio" last="Barricarte">Aurelio Barricarte</name><affiliation><nlm:affiliation>CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Sanchez, Maria Jose" sort="Sanchez, Maria Jose" uniqKey="Sanchez M" first="María-José" last="Sánchez">María-José Sánchez</name><affiliation><nlm:affiliation>CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Dorronsoro, Miren" sort="Dorronsoro, Miren" uniqKey="Dorronsoro M" first="Miren" last="Dorronsoro">Miren Dorronsoro</name><affiliation><nlm:affiliation>CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Quir S, J Ram N" sort="Quir S, J Ram N" uniqKey="Quir S J" first="J Ram N" last="Quir S">J Ram N Quir S</name><affiliation><nlm:affiliation>Public Health Directorate, Asturias, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Agudo, Antonio" sort="Agudo, Antonio" uniqKey="Agudo A" first="Antonio" last="Agudo">Antonio Agudo</name><affiliation><nlm:affiliation>Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Sjoberg, Klas" sort="Sjoberg, Klas" uniqKey="Sjoberg K" first="Klas" last="Sjöberg">Klas Sjöberg</name><affiliation><nlm:affiliation>Department of Clinical Sciences, Lund University, Malmö, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Ohlsson, Bodil" sort="Ohlsson, Bodil" uniqKey="Ohlsson B" first="Bodil" last="Ohlsson">Bodil Ohlsson</name><affiliation><nlm:affiliation>Department of Clinical Sciences, Division of Internal Medicine, Skåne University Hospital, Malmö, Lund University, Lund, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Hemmingsson, Oskar" sort="Hemmingsson, Oskar" uniqKey="Hemmingsson O" first="Oskar" last="Hemmingsson">Oskar Hemmingsson</name><affiliation><nlm:affiliation>Department of Surgical and Perioperative Sciences, Kirurgcentrum, Norrlands Universitetssjukhus, Umeå, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Werner, M Rten" sort="Werner, M Rten" uniqKey="Werner M" first="M Rten" last="Werner">M Rten Werner</name><affiliation><nlm:affiliation>Department of Medicine Sections for Hepatology and Gastroenterology, Umeå University Hospital, SE-90185, Umeå, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Bradbury, Kathryn E" sort="Bradbury, Kathryn E" uniqKey="Bradbury K" first="Kathryn E" last="Bradbury">Kathryn E. Bradbury</name><affiliation><nlm:affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation><nlm:affiliation>Clinical Gerontology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Wareham, Nick" sort="Wareham, Nick" uniqKey="Wareham N" first="Nick" last="Wareham">Nick Wareham</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Tsilidis, Konstantinos K" sort="Tsilidis, Konstantinos K" uniqKey="Tsilidis K" first="Konstantinos K" last="Tsilidis">Konstantinos K. Tsilidis</name><affiliation><nlm:affiliation>Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.</nlm:affiliation></affiliation></author><author><name sortKey="Aune, Dagfinn" sort="Aune, Dagfinn" uniqKey="Aune D" first="Dagfinn" last="Aune">Dagfinn Aune</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Scalbert, Augustin" sort="Scalbert, Augustin" uniqKey="Scalbert A" first="Augustin" last="Scalbert">Augustin Scalbert</name><affiliation><nlm:affiliation>Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Romieu, Isabelle" sort="Romieu, Isabelle" uniqKey="Romieu I" first="Isabelle" last="Romieu">Isabelle Romieu</name><affiliation><nlm:affiliation>Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Jenab, Mazda" sort="Jenab, Mazda" uniqKey="Jenab M" first="Mazda" last="Jenab">Mazda Jenab</name><affiliation><nlm:affiliation>Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France. jenabm@iarc.fr.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28372583</idno><idno type="pmid">28372583</idno><idno type="doi">10.1186/s12916-017-0830-8</idno><idno type="wicri:Area/PubMed/Corpus">000E48</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000E48</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Exposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma: a nested case-control study.</title><author><name sortKey="Fedirko, Veronika" sort="Fedirko, Veronika" uniqKey="Fedirko V" first="Veronika" last="Fedirko">Veronika Fedirko</name><affiliation><nlm:affiliation>Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA. vfedirk@emory.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Tran, Hao Quang" sort="Tran, Hao Quang" uniqKey="Tran H" first="Hao Quang" last="Tran">Hao Quang Tran</name><affiliation><nlm:affiliation>Center for Inflammation, Immunity, and Infection Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, 30303, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Gewirtz, Andrew T" sort="Gewirtz, Andrew T" uniqKey="Gewirtz A" first="Andrew T" last="Gewirtz">Andrew T. Gewirtz</name><affiliation><nlm:affiliation>Center for Inflammation, Immunity, and Infection Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, 30303, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Stepien, Magdalena" sort="Stepien, Magdalena" uniqKey="Stepien M" first="Magdalena" last="Stepien">Magdalena Stepien</name><affiliation><nlm:affiliation>Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Trichopoulou, Antonia" sort="Trichopoulou, Antonia" uniqKey="Trichopoulou A" first="Antonia" last="Trichopoulou">Antonia Trichopoulou</name><affiliation><nlm:affiliation>Hellenic Health Foundation, 13 Kaisareias Street, Athens, GR-115 27, Greece.</nlm:affiliation></affiliation></author><author><name sortKey="Aleksandrova, Krasimira" sort="Aleksandrova, Krasimira" uniqKey="Aleksandrova K" first="Krasimira" last="Aleksandrova">Krasimira Aleksandrova</name><affiliation><nlm:affiliation>Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nutrition, Immunity and Metabolism Start-up Lab, Nuthetal, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Olsen, Anja" sort="Olsen, Anja" uniqKey="Olsen A" first="Anja" last="Olsen">Anja Olsen</name><affiliation><nlm:affiliation>Danish Cancer Society Research Center, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Tj Nneland, Anne" sort="Tj Nneland, Anne" uniqKey="Tj Nneland A" first="Anne" last="Tj Nneland">Anne Tj Nneland</name><affiliation><nlm:affiliation>Danish Cancer Society Research Center, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Overvad, Kim" sort="Overvad, Kim" uniqKey="Overvad K" first="Kim" last="Overvad">Kim Overvad</name><affiliation><nlm:affiliation>Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Carbonnel, Franck" sort="Carbonnel, Franck" uniqKey="Carbonnel F" first="Franck" last="Carbonnel">Franck Carbonnel</name><affiliation><nlm:affiliation>Université Paris-Saclay, Université Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Boutron Ruault, Marie Christine" sort="Boutron Ruault, Marie Christine" uniqKey="Boutron Ruault M" first="Marie-Christine" last="Boutron-Ruault">Marie-Christine Boutron-Ruault</name><affiliation><nlm:affiliation>Université Paris-Saclay, Université Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:affiliation>Université Paris-Saclay, Université Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Kuhn, Tilman" sort="Kuhn, Tilman" uniqKey="Kuhn T" first="Tilman" last="Kühn">Tilman Kühn</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name><affiliation><nlm:affiliation>Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Bamia, Christina" sort="Bamia, Christina" uniqKey="Bamia C" first="Christina" last="Bamia">Christina Bamia</name><affiliation><nlm:affiliation>Hellenic Health Foundation, 13 Kaisareias Street, Athens, GR-115 27, Greece.</nlm:affiliation></affiliation></author><author><name sortKey="Lagiou, Pagona" sort="Lagiou, Pagona" uniqKey="Lagiou P" first="Pagona" last="Lagiou">Pagona Lagiou</name><affiliation><nlm:affiliation>Hellenic Health Foundation, 13 Kaisareias Street, Athens, GR-115 27, Greece.</nlm:affiliation></affiliation></author><author><name sortKey="Grioni, Sara" sort="Grioni, Sara" uniqKey="Grioni S" first="Sara" last="Grioni">Sara Grioni</name><affiliation><nlm:affiliation>Epidemiology and Prevention Unit Fondazione IRCCS Istituto Nazionale dei Tumori Via Venezian, 1 20133, Milano, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Panico, Salvatore" sort="Panico, Salvatore" uniqKey="Panico S" first="Salvatore" last="Panico">Salvatore Panico</name><affiliation><nlm:affiliation>Dipartimento di Medicina Clinica Echirurgia Federico II University, Naples, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Palli, Domenico" sort="Palli, Domenico" uniqKey="Palli D" first="Domenico" last="Palli">Domenico Palli</name><affiliation><nlm:affiliation>Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute - ISPO, Florence, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Tumino, Rosario" sort="Tumino, Rosario" uniqKey="Tumino R" first="Rosario" last="Tumino">Rosario Tumino</name><affiliation><nlm:affiliation>Cancer Registry and Histopathology Unit, "Civic -M.P. Arezzo" Hospital, ASP, Ragusa, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Naccarati, Alessio" sort="Naccarati, Alessio" uniqKey="Naccarati A" first="Alessio" last="Naccarati">Alessio Naccarati</name><affiliation><nlm:affiliation>Molecular and Genetic Epidemiology Unit, HuGeF, Human Genetics Foundation, Torino, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H" last="Peeters">Petra H. Peeters</name><affiliation><nlm:affiliation>Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Bueno De Mesquita, H B" sort="Bueno De Mesquita, H B" uniqKey="Bueno De Mesquita H" first="H B" last="Bueno-De-Mesquita">H B Bueno-De-Mesquita</name><affiliation><nlm:affiliation>Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name><affiliation><nlm:affiliation>Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Casta O, Jose Maria Huerta" sort="Casta O, Jose Maria Huerta" uniqKey="Casta O J" first="José María Huerta" last="Casta O">José María Huerta Casta O</name><affiliation><nlm:affiliation>Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Barricarte, Aurelio" sort="Barricarte, Aurelio" uniqKey="Barricarte A" first="Aurelio" last="Barricarte">Aurelio Barricarte</name><affiliation><nlm:affiliation>CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Sanchez, Maria Jose" sort="Sanchez, Maria Jose" uniqKey="Sanchez M" first="María-José" last="Sánchez">María-José Sánchez</name><affiliation><nlm:affiliation>CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Dorronsoro, Miren" sort="Dorronsoro, Miren" uniqKey="Dorronsoro M" first="Miren" last="Dorronsoro">Miren Dorronsoro</name><affiliation><nlm:affiliation>CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Quir S, J Ram N" sort="Quir S, J Ram N" uniqKey="Quir S J" first="J Ram N" last="Quir S">J Ram N Quir S</name><affiliation><nlm:affiliation>Public Health Directorate, Asturias, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Agudo, Antonio" sort="Agudo, Antonio" uniqKey="Agudo A" first="Antonio" last="Agudo">Antonio Agudo</name><affiliation><nlm:affiliation>Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Sjoberg, Klas" sort="Sjoberg, Klas" uniqKey="Sjoberg K" first="Klas" last="Sjöberg">Klas Sjöberg</name><affiliation><nlm:affiliation>Department of Clinical Sciences, Lund University, Malmö, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Ohlsson, Bodil" sort="Ohlsson, Bodil" uniqKey="Ohlsson B" first="Bodil" last="Ohlsson">Bodil Ohlsson</name><affiliation><nlm:affiliation>Department of Clinical Sciences, Division of Internal Medicine, Skåne University Hospital, Malmö, Lund University, Lund, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Hemmingsson, Oskar" sort="Hemmingsson, Oskar" uniqKey="Hemmingsson O" first="Oskar" last="Hemmingsson">Oskar Hemmingsson</name><affiliation><nlm:affiliation>Department of Surgical and Perioperative Sciences, Kirurgcentrum, Norrlands Universitetssjukhus, Umeå, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Werner, M Rten" sort="Werner, M Rten" uniqKey="Werner M" first="M Rten" last="Werner">M Rten Werner</name><affiliation><nlm:affiliation>Department of Medicine Sections for Hepatology and Gastroenterology, Umeå University Hospital, SE-90185, Umeå, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Bradbury, Kathryn E" sort="Bradbury, Kathryn E" uniqKey="Bradbury K" first="Kathryn E" last="Bradbury">Kathryn E. Bradbury</name><affiliation><nlm:affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation><nlm:affiliation>Clinical Gerontology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Wareham, Nick" sort="Wareham, Nick" uniqKey="Wareham N" first="Nick" last="Wareham">Nick Wareham</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Tsilidis, Konstantinos K" sort="Tsilidis, Konstantinos K" uniqKey="Tsilidis K" first="Konstantinos K" last="Tsilidis">Konstantinos K. Tsilidis</name><affiliation><nlm:affiliation>Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.</nlm:affiliation></affiliation></author><author><name sortKey="Aune, Dagfinn" sort="Aune, Dagfinn" uniqKey="Aune D" first="Dagfinn" last="Aune">Dagfinn Aune</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Scalbert, Augustin" sort="Scalbert, Augustin" uniqKey="Scalbert A" first="Augustin" last="Scalbert">Augustin Scalbert</name><affiliation><nlm:affiliation>Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Romieu, Isabelle" sort="Romieu, Isabelle" uniqKey="Romieu I" first="Isabelle" last="Romieu">Isabelle Romieu</name><affiliation><nlm:affiliation>Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Jenab, Mazda" sort="Jenab, Mazda" uniqKey="Jenab M" first="Mazda" last="Jenab">Mazda Jenab</name><affiliation><nlm:affiliation>Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France. jenabm@iarc.fr.</nlm:affiliation></affiliation></author></analytic><series><title level="j">BMC medicine</title><idno type="eISSN">1741-7015</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Carcinoma, Hepatocellular (blood)</term><term>Carcinoma, Hepatocellular (immunology)</term><term>Carcinoma, Hepatocellular (microbiology)</term><term>Case-Control Studies</term><term>Cohort Studies</term><term>Female</term><term>Flagellin (immunology)</term><term>Humans</term><term>Immunoglobulin A (blood)</term><term>Immunoglobulin A (immunology)</term><term>Immunoglobulin G (blood)</term><term>Immunoglobulin G (immunology)</term><term>Lipopolysaccharides (immunology)</term><term>Liver Neoplasms (blood)</term><term>Liver Neoplasms (immunology)</term><term>Liver Neoplasms (microbiology)</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term><term>Risk Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Immunoglobulin A</term><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Flagellin</term><term>Immunoglobulin A</term><term>Immunoglobulin G</term><term>Lipopolysaccharides</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Carcinoma, Hepatocellular</term><term>Liver Neoplasms</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Carcinoma, Hepatocellular</term><term>Liver Neoplasms</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Carcinoma, Hepatocellular</term><term>Liver Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Case-Control Studies</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term><term>Risk Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Leakage of bacterial products across the gut barrier may play a role in liver diseases which often precede the development of liver cancer. However, human studies, particularly from prospective settings, are lacking.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28372583</PMID><DateCreated><Year>2017</Year><Month>04</Month><Day>04</Day></DateCreated><DateCompleted><Year>2017</Year><Month>07</Month><Day>10</Day></DateCompleted><DateRevised><Year>2017</Year><Month>07</Month><Day>13</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1741-7015</ISSN><JournalIssue CitedMedium="Internet"><Volume>15</Volume><Issue>1</Issue><PubDate><Year>2017</Year><Month>Apr</Month><Day>04</Day></PubDate></JournalIssue><Title>BMC medicine</Title><ISOAbbreviation>BMC Med</ISOAbbreviation></Journal><ArticleTitle>Exposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma: a nested case-control study.</ArticleTitle><Pagination><MedlinePgn>72</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s12916-017-0830-8</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Leakage of bacterial products across the gut barrier may play a role in liver diseases which often precede the development of liver cancer. However, human studies, particularly from prospective settings, are lacking.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We used a case-control study design nested within a large prospective cohort to assess the association between circulating levels of anti-lipopolysaccharide (LPS) and anti-flagellin immunoglobulin A (IgA) and G (IgG) (reflecting long-term exposures to LPS and flagellin, respectively) and risk of hepatocellular carcinoma. A total of 139 men and women diagnosed with hepatocellular carcinoma between 1992 and 2010 were matched to 139 control subjects. Multivariable rate ratios (RRs), including adjustment for potential confounders, hepatitis B/C positivity, and degree of liver dysfunction, were calculated with conditional logistic regression.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Antibody response to LPS and flagellin was associated with a statistically significant increase in the risk of hepatocellular carcinoma (highest vs. lowest quartile: RR = 11.76, 95% confidence interval = 1.70-81.40; P trend = 0.021). This finding did not vary substantially by time from enrollment to diagnosis, and did not change after adjustment for chronic infection with hepatitis B and C viruses.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These novel findings, based on exposures up to several years prior to diagnosis, support a role for gut-derived bacterial products in hepatocellular carcinoma development. Further study into the role of gut barrier failure and exposure to bacterial products in liver diseases is warranted.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Fedirko</LastName><ForeName>Veronika</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA. vfedirk@emory.edu.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Winship Cancer Institute, Emory University, Atlanta, GA, USA. vfedirk@emory.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tran</LastName><ForeName>Hao Quang</ForeName><Initials>HQ</Initials><AffiliationInfo><Affiliation>Center for Inflammation, Immunity, and Infection Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, 30303, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gewirtz</LastName><ForeName>Andrew T</ForeName><Initials>AT</Initials><AffiliationInfo><Affiliation>Center for Inflammation, Immunity, and Infection Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, 30303, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stepien</LastName><ForeName>Magdalena</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Trichopoulou</LastName><ForeName>Antonia</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Hellenic Health Foundation, 13 Kaisareias Street, Athens, GR-115 27, Greece.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Hygiene, Epidemiology and Medical Statistics, WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, University of Athens Medical School, Athens, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aleksandrova</LastName><ForeName>Krasimira</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nutrition, Immunity and Metabolism Start-up Lab, Nuthetal, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Olsen</LastName><ForeName>Anja</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Danish Cancer Society Research Center, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tjønneland</LastName><ForeName>Anne</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Danish Cancer Society Research Center, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Overvad</LastName><ForeName>Kim</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carbonnel</LastName><ForeName>Franck</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Université Paris-Saclay, Université Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Gustave Roussy, Villejuif, F-94805, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Gastroenterology, Assistance Publique-Hôpitaux de Paris (AP-HP), University hospitals Paris-Sud, Site de Bicêtre, Paris Sud University, Paris XI, Le Kremlin Bicêtre, Villejuif, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boutron-Ruault</LastName><ForeName>Marie-Christine</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Université Paris-Saclay, Université Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Gustave Roussy, Villejuif, F-94805, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Severi</LastName><ForeName>Gianluca</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Université Paris-Saclay, Université Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Gustave Roussy, Villejuif, F-94805, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Human Genetics Foundation (HuGeF), Torino, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Cancer Council Victoria and University of Melbourne, Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kühn</LastName><ForeName>Tilman</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kaaks</LastName><ForeName>Rudolf</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boeing</LastName><ForeName>Heiner</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bamia</LastName><ForeName>Christina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Hellenic Health Foundation, 13 Kaisareias Street, Athens, GR-115 27, Greece.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Hygiene, Epidemiology and Medical Statistics, WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, University of Athens Medical School, Athens, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lagiou</LastName><ForeName>Pagona</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Hellenic Health Foundation, 13 Kaisareias Street, Athens, GR-115 27, Greece.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Hygiene, Epidemiology and Medical Statistics, WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, University of Athens Medical School, Athens, Greece.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grioni</LastName><ForeName>Sara</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Epidemiology and Prevention Unit Fondazione IRCCS Istituto Nazionale dei Tumori Via Venezian, 1 20133, Milano, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Panico</LastName><ForeName>Salvatore</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Dipartimento di Medicina Clinica Echirurgia Federico II University, Naples, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Palli</LastName><ForeName>Domenico</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute - ISPO, Florence, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tumino</LastName><ForeName>Rosario</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Cancer Registry and Histopathology Unit, "Civic -M.P. Arezzo" Hospital, ASP, Ragusa, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Naccarati</LastName><ForeName>Alessio</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Molecular and Genetic Epidemiology Unit, HuGeF, Human Genetics Foundation, Torino, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peeters</LastName><ForeName>Petra H</ForeName><Initials>PH</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bueno-de-Mesquita</LastName><ForeName>H B</ForeName><Initials>HB</Initials><AffiliationInfo><Affiliation>Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weiderpass</LastName><ForeName>Elisabete</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Research, Cancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, Norway.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Castaño</LastName><ForeName>José María Huerta</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barricarte</LastName><ForeName>Aurelio</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Navarra Public Health Institute, Pamplona, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sánchez</LastName><ForeName>María-José</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs.GRANADA. Hospitales Universitarios de Granada, Universidad de Granada, Granada, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dorronsoro</LastName><ForeName>Miren</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Basque Regional Health Department, San Sebastian, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Quirós</LastName><ForeName>J Ramón</ForeName><Initials>JR</Initials><AffiliationInfo><Affiliation>Public Health Directorate, Asturias, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Agudo</LastName><ForeName>Antonio</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sjöberg</LastName><ForeName>Klas</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Clinical Sciences, Lund University, Malmö, Sweden.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Gastroenterology and Nutrition, Skåne University Hospital, Malmö, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ohlsson</LastName><ForeName>Bodil</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Clinical Sciences, Division of Internal Medicine, Skåne University Hospital, Malmö, Lund University, Lund, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hemmingsson</LastName><ForeName>Oskar</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Department of Surgical and Perioperative Sciences, Kirurgcentrum, Norrlands Universitetssjukhus, Umeå, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Werner</LastName><ForeName>Mårten</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medicine Sections for Hepatology and Gastroenterology, Umeå University Hospital, SE-90185, Umeå, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bradbury</LastName><ForeName>Kathryn E</ForeName><Initials>KE</Initials><AffiliationInfo><Affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khaw</LastName><ForeName>Kay-Tee</ForeName><Initials>KT</Initials><AffiliationInfo><Affiliation>Clinical Gerontology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wareham</LastName><ForeName>Nick</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tsilidis</LastName><ForeName>Konstantinos K</ForeName><Initials>KK</Initials><AffiliationInfo><Affiliation>Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aune</LastName><ForeName>Dagfinn</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Scalbert</LastName><ForeName>Augustin</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Romieu</LastName><ForeName>Isabelle</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Riboli</LastName><ForeName>Elio</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jenab</LastName><ForeName>Mazda</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France. 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MajorTopicYN="N">Immunoglobulin G</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008070" MajorTopicYN="N">Lipopolysaccharides</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008113" MajorTopicYN="N">Liver Neoplasms</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective 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