Molecular basis for the behavioral effects of the odorant degrading enzyme Esterase 6 in Drosophila.
Identifieur interne : 000D65 ( PubMed/Corpus ); précédent : 000D64; suivant : 000D66Molecular basis for the behavioral effects of the odorant degrading enzyme Esterase 6 in Drosophila.
Auteurs : Faisal Younus ; Nicholas J. Fraser ; Chris W. Coppin ; Jian-Wei Liu ; Galen J. Correy ; Thomas Chertemps ; Gunjan Pandey ; Martine Maïbèche ; Colin J. Jackson ; John G. OakeshottSource :
- Scientific reports [ 2045-2322 ] ; 2017.
Abstract
Previous electrophysiological and behavioural studies implicate esterase 6 in the processing of the pheromone cis-vaccenyl acetate and various food odorants that affect aggregation and reproductive behaviours. Here we show esterase 6 has relatively high activity against many of the short-mid chain food esters, but negligible activity against cis-vaccenyl acetate. The crystal structure of esterase 6 confirms its substrate-binding site can accommodate many short-mid chain food esters but not cis-vaccenyl acetate. Immunohistochemical assays show esterase 6 is expressed in non-neuronal cells in the third antennal segment that could be accessory or epidermal cells surrounding numerous olfactory sensilla, including basiconics involved in food odorant detection. Esterase 6 is also produced in trichoid sensilla, but not in the same cell types as the cis-vaccenyl acetate binding protein LUSH. Our data support a model in which esterase 6 acts as a direct odorant degrading enzyme for many bioactive food esters, but not cis-vaccenyl acetate.
DOI: 10.1038/srep46188
PubMed: 28393888
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pubmed:28393888Le document en format XML
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Coppin</name><affiliation><nlm:affiliation>CSIRO Land and Water, Black Mountain, Canberra, ACT, 2601, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Jian Wei" sort="Liu, Jian Wei" uniqKey="Liu J" first="Jian-Wei" last="Liu">Jian-Wei Liu</name><affiliation><nlm:affiliation>CSIRO Land and Water, Black Mountain, Canberra, ACT, 2601, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Correy, Galen J" sort="Correy, Galen J" uniqKey="Correy G" first="Galen J" last="Correy">Galen J. 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Fraser</name><affiliation><nlm:affiliation>Research School of Chemistry, Australian National University, Canberra, ACT, 2601, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Coppin, Chris W" sort="Coppin, Chris W" uniqKey="Coppin C" first="Chris W" last="Coppin">Chris W. Coppin</name><affiliation><nlm:affiliation>CSIRO Land and Water, Black Mountain, Canberra, ACT, 2601, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Jian Wei" sort="Liu, Jian Wei" uniqKey="Liu J" first="Jian-Wei" last="Liu">Jian-Wei Liu</name><affiliation><nlm:affiliation>CSIRO Land and Water, Black Mountain, Canberra, ACT, 2601, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Correy, Galen J" sort="Correy, Galen J" uniqKey="Correy G" first="Galen J" last="Correy">Galen J. Correy</name><affiliation><nlm:affiliation>Research School of Chemistry, Australian National University, Canberra, ACT, 2601, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Chertemps, Thomas" sort="Chertemps, Thomas" uniqKey="Chertemps T" first="Thomas" last="Chertemps">Thomas Chertemps</name><affiliation><nlm:affiliation>Université Pierre et Marie Curie, Institut d'Ecologie et des Sciences de l'Environnement de Paris, 75252, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Pandey, Gunjan" sort="Pandey, Gunjan" uniqKey="Pandey G" first="Gunjan" last="Pandey">Gunjan Pandey</name><affiliation><nlm:affiliation>CSIRO Land and Water, Black Mountain, Canberra, ACT, 2601, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Maibeche, Martine" sort="Maibeche, Martine" uniqKey="Maibeche M" first="Martine" last="Maïbèche">Martine Maïbèche</name><affiliation><nlm:affiliation>Université Pierre et Marie Curie, Institut d'Ecologie et des Sciences de l'Environnement de Paris, 75252, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Jackson, Colin J" sort="Jackson, Colin J" uniqKey="Jackson C" first="Colin J" last="Jackson">Colin J. Jackson</name><affiliation><nlm:affiliation>Research School of Chemistry, Australian National University, Canberra, ACT, 2601, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Oakeshott, John G" sort="Oakeshott, John G" uniqKey="Oakeshott J" first="John G" last="Oakeshott">John G. Oakeshott</name><affiliation><nlm:affiliation>CSIRO Land and Water, Black Mountain, Canberra, ACT, 2601, Australia.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Scientific reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Previous electrophysiological and behavioural studies implicate esterase 6 in the processing of the pheromone cis-vaccenyl acetate and various food odorants that affect aggregation and reproductive behaviours. Here we show esterase 6 has relatively high activity against many of the short-mid chain food esters, but negligible activity against cis-vaccenyl acetate. The crystal structure of esterase 6 confirms its substrate-binding site can accommodate many short-mid chain food esters but not cis-vaccenyl acetate. Immunohistochemical assays show esterase 6 is expressed in non-neuronal cells in the third antennal segment that could be accessory or epidermal cells surrounding numerous olfactory sensilla, including basiconics involved in food odorant detection. Esterase 6 is also produced in trichoid sensilla, but not in the same cell types as the cis-vaccenyl acetate binding protein LUSH. Our data support a model in which esterase 6 acts as a direct odorant degrading enzyme for many bioactive food esters, but not cis-vaccenyl acetate.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">28393888</PMID><DateCreated><Year>2017</Year><Month>04</Month><Day>10</Day></DateCreated><DateRevised><Year>2017</Year><Month>04</Month><Day>13</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2045-2322</ISSN><JournalIssue CitedMedium="Internet"><Volume>7</Volume><PubDate><Year>2017</Year><Month>Apr</Month><Day>10</Day></PubDate></JournalIssue><Title>Scientific reports</Title><ISOAbbreviation>Sci Rep</ISOAbbreviation></Journal><ArticleTitle>Molecular basis for the behavioral effects of the odorant degrading enzyme Esterase 6 in Drosophila.</ArticleTitle><Pagination><MedlinePgn>46188</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/srep46188</ELocationID><Abstract><AbstractText>Previous electrophysiological and behavioural studies implicate esterase 6 in the processing of the pheromone cis-vaccenyl acetate and various food odorants that affect aggregation and reproductive behaviours. Here we show esterase 6 has relatively high activity against many of the short-mid chain food esters, but negligible activity against cis-vaccenyl acetate. The crystal structure of esterase 6 confirms its substrate-binding site can accommodate many short-mid chain food esters but not cis-vaccenyl acetate. Immunohistochemical assays show esterase 6 is expressed in non-neuronal cells in the third antennal segment that could be accessory or epidermal cells surrounding numerous olfactory sensilla, including basiconics involved in food odorant detection. Esterase 6 is also produced in trichoid sensilla, but not in the same cell types as the cis-vaccenyl acetate binding protein LUSH. Our data support a model in which esterase 6 acts as a direct odorant degrading enzyme for many bioactive food esters, but not cis-vaccenyl acetate.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Younus</LastName><ForeName>Faisal</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>CSIRO Land and Water, Black Mountain, Canberra, ACT, 2601, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Research School of Chemistry, Australian National University, Canberra, ACT, 2601, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fraser</LastName><ForeName>Nicholas J</ForeName><Initials>NJ</Initials><AffiliationInfo><Affiliation>Research School of Chemistry, Australian National University, Canberra, ACT, 2601, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Coppin</LastName><ForeName>Chris W</ForeName><Initials>CW</Initials><AffiliationInfo><Affiliation>CSIRO Land and Water, Black Mountain, Canberra, ACT, 2601, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Jian-Wei</ForeName><Initials>JW</Initials><AffiliationInfo><Affiliation>CSIRO Land and Water, Black Mountain, Canberra, ACT, 2601, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Correy</LastName><ForeName>Galen J</ForeName><Initials>GJ</Initials><AffiliationInfo><Affiliation>Research School of Chemistry, Australian National University, Canberra, ACT, 2601, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chertemps</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Université Pierre et Marie Curie, Institut d'Ecologie et des Sciences de l'Environnement de Paris, 75252, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pandey</LastName><ForeName>Gunjan</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>CSIRO Land and Water, Black Mountain, Canberra, ACT, 2601, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maïbèche</LastName><ForeName>Martine</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Université Pierre et Marie Curie, Institut d'Ecologie et des Sciences de l'Environnement de Paris, 75252, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jackson</LastName><ForeName>Colin J</ForeName><Initials>CJ</Initials><AffiliationInfo><Affiliation>Research School of Chemistry, Australian National University, Canberra, ACT, 2601, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oakeshott</LastName><ForeName>John G</ForeName><Initials>JG</Initials><AffiliationInfo><Affiliation>CSIRO Land and Water, Black Mountain, Canberra, ACT, 2601, Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>04</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Sci Rep</MedlineTA><NlmUniqueID>101563288</NlmUniqueID><ISSNLinking>2045-2322</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Arch Insect Biochem Physiol. 2014 Jun;86(2):85-99</RefSource><PMID Version="1">24753123</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2015 Sep;201(9):927-32</RefSource><PMID Version="1">26105507</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Curr Biol. 2013 Dec 16;23(24):2472-80</RefSource><PMID Version="1">24316206</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Curr Opin Neurobiol. 2015 Oct;34:95-102</RefSource><PMID Version="1">25747730</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Struct Biol. 2003 Sep;10(9):694-700</RefSource><PMID Version="1">12881720</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>BMC Biol. 2012 Jun 21;10 :56</RefSource><PMID Version="1">22715942</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nucleic Acids Res. 2003 Jul 1;31(13):3352-5</RefSource><PMID Version="1">12824325</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Gene. 1996 Oct 17;176(1-2):49-53</RefSource><PMID Version="1">8918231</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Microb Cell Fact. 2009 May 14;8:26</RefSource><PMID Version="1">19442264</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Insect Biochem Mol Biol. 2014 Oct;53:30-43</RefSource><PMID Version="1">25038463</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Chem Biol. 2014 Dec;10 (12 ):1066-72</RefSource><PMID Version="1">25344815</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Biol. 2013;11(4):e1001546</RefSource><PMID Version="1">23637570</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genetica. 2000;110(3):231-44</RefSource><PMID Version="1">11766844</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genetics. 1998 Oct;150(2):711-21</RefSource><PMID Version="1">9755202</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Front Physiol. 2015 Nov 05;6:315</RefSource><PMID Version="1">26594178</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 1989 Feb;86(4):1426-30</RefSource><PMID Version="1">2493155</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurochem. 1994 Jul;63(1):41-51</RefSource><PMID Version="1">8207445</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Learn Mem. 2009 Nov 19;16(12):743-50</RefSource><PMID Version="1">19926779</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2011 Sep 21;31(38):13357-75</RefSource><PMID Version="1">21940430</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Insect Mol Biol. 2008 Aug;17(4):361-73</RefSource><PMID Version="1">18651918</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2011;6(7):e22016</RefSource><PMID Version="1">21818287</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Bioinformatics. 2003 Jan 22;19(2):311-2</RefSource><PMID Version="1">12538265</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 1985 Dec;82(24):8827-31</RefSource><PMID Version="1">3001718</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2008;3(10):e3542</RefSource><PMID Version="1">18974885</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Chem Senses. 2010 Sep;35(7):551-63</RefSource><PMID Version="1">20530377</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell Rep. 2012 Apr 19;1(4):392-9</RefSource><PMID Version="1">22832228</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Sci Rep. 2016 Feb 25;6:21841</RefSource><PMID Version="1">26912260</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Exp Biol. 2003 Feb;206(Pt 4):715-24</RefSource><PMID Version="1">12517989</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):12987-95</RefSource><PMID Version="1">21746926</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell. 2004 Jun 25;117(7):965-79</RefSource><PMID Version="1">15210116</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuron. 2004 Sep 2;43(5):703-14</RefSource><PMID Version="1">15339651</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Science. 1980 Mar 28;207(4438):1483-5</RefSource><PMID Version="1">6767273</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2011 Sep 28;478(7368):236-40</RefSource><PMID Version="1">21964331</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Science. 1994 Mar 4;263(5151):1276-8</RefSource><PMID Version="1">8122110</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2013 Jun 4;110(23 ):E2134-43</RefSource><PMID Version="1">23690583</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biochemistry. 2011 May 31;50(21):4402-10</RefSource><PMID Version="1">21506553</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Insect Mol Biol. 2013 Feb;22(1):31-40</RefSource><PMID Version="1">23121132</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2015 May 26;112(21):E2829-35</RefSource><PMID Version="1">25964351</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Insect Mol Biol. 2010 Feb;19(1):87-97</RefSource><PMID Version="1">20002215</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Protein Sci. 2000 Jun;9(6):1063-72</RefSource><PMID Version="1">10892800</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Annu Rev Entomol. 2013;58:373-91</RefSource><PMID Version="1">23020622</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genetica. 1993;88(1):11-28</RefSource><PMID Version="1">8375665</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Chem Senses. 1999 Oct;24(5):481-95</RefSource><PMID Version="1">10576256</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Science. 1983 Oct 28;222(4622):419-21</RefSource><PMID Version="1">17789533</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2011;6(12 ):e29147</RefSource><PMID Version="1">22216190</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell Rep. 2014 Oct 23;9(2):425-32</RefSource><PMID Version="1">25310977</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biochemistry. 2006 Apr 4;45(13):4045-57</RefSource><PMID Version="1">16566578</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Chem Ecol. 1985 Dec;11(12):1747-56</RefSource><PMID Version="1">24311338</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Curr Biol. 2010 Oct 26;20(20):1846-52</RefSource><PMID Version="1">20933425</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W382-8</RefSource><PMID Version="1">15980494</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10177-82</RefSource><PMID Version="1">23733941</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Neurosci. 2007 May;10 (5):623-30</RefSource><PMID Version="1">17417635</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trends Biotechnol. 2007 Jun;25(6):247-9</RefSource><PMID Version="1">17433847</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nucleic Acids Res. 2013 Jan;41(Database issue):D423-9</RefSource><PMID Version="1">23193256</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14075-9</RefSource><PMID Version="1">16172410</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trends Neurosci. 2007 Oct;30(10):512-9</RefSource><PMID Version="1">17825436</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Structure. 2006 Nov;14(11):1617-22</RefSource><PMID Version="1">17098187</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nucleic Acids Res. 2009 Jul;37(Web Server issue):W480-4</RefSource><PMID Version="1">19465380</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biochem Genet. 1993 Aug;31(7-8):259-78</RefSource><PMID Version="1">8274134</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Elife. 2014 Dec 16;3:e04147</RefSource><PMID Version="1">25512254</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Curr Opin Insect Sci. 2016 Feb;13:70-6</RefSource><PMID Version="1">27436555</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell. 2006 Apr 7;125(1):143-60</RefSource><PMID Version="1">16615896</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Microsc Res Tech. 2001 Dec 1;55(5):297-306</RefSource><PMID Version="1">11754509</PMID></CommentsCorrections></CommentsCorrectionsList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>12</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>03</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>4</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>4</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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