Genetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer: a Mendelian Randomization analysis using data from three large cohort studies.
Identifieur interne : 000B81 ( PubMed/Corpus ); précédent : 000B80; suivant : 000B82Genetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer: a Mendelian Randomization analysis using data from three large cohort studies.
Auteurs : Katharina Nimptsch ; Mingyang Song ; Krasimira Aleksandrova ; Michail Katsoulis ; Heinz Freisling ; Mazda Jenab ; Marc J. Gunter ; Konstantinos K. Tsilidis ; Elisabete Weiderpass ; H Bas Bueno-De-Mesquita ; Dawn Q. Chong ; Majken K. Jensen ; Chunsen Wu ; Kim Overvad ; Tilman Kühn ; Myrto Barrdahl ; Olle Melander ; Karin Jirström ; Petra H. Peeters ; Sabina Sieri ; Salvatore Panico ; Amanda J. Cross ; Elio Riboli ; Bethany Van Guelpen ; Robin Myte ; José María Huerta ; Miguel Rodriguez-Barranco ; José Ram N Quir S ; Miren Dorronsoro ; Anne Tj Nneland ; Anja Olsen ; Ruth Travis ; Marie-Christine Boutron-Ruault ; Franck Carbonnel ; Gianluca Severi ; Catalina Bonet ; Domenico Palli ; Jürgen Janke ; Young-Ae Lee ; Heiner Boeing ; Edward L. Giovannucci ; Shuji Ogino ; Charles S. Fuchs ; Eric Rimm ; Kana Wu ; Andrew T. Chan ; Tobias PischonSource :
- European journal of epidemiology [ 1573-7284 ] ; 2017.
Abstract
Higher levels of circulating adiponectin have been related to lower risk of colorectal cancer in several prospective cohort studies, but it remains unclear whether this association may be causal. We aimed to improve causal inference in a Mendelian Randomization meta-analysis using nested case-control studies of the European Prospective Investigation into Cancer and Nutrition (EPIC, 623 cases, 623 matched controls), the Health Professionals Follow-up Study (HPFS, 231 cases, 230 controls) and the Nurses' Health Study (NHS, 399 cases, 774 controls) with available data on pre-diagnostic adiponectin concentrations and selected single nucleotide polymorphisms in the ADIPOQ gene. We created an ADIPOQ allele score that explained approximately 3% of the interindividual variation in adiponectin concentrations. The ADIPOQ allele score was not associated with risk of colorectal cancer in logistic regression analyses (pooled OR per score-unit unit 0.97, 95% CI 0.91, 1.04). Genetically determined twofold higher adiponectin was not significantly associated with risk of colorectal cancer using the ADIPOQ allele score as instrumental variable (pooled OR 0.73, 95% CI 0.40, 1.34). In a summary instrumental variable analysis (based on previously published data) with higher statistical power, no association between genetically determined twofold higher adiponectin and risk of colorectal cancer was observed (0.99, 95% CI 0.93, 1.06 in women and 0.94, 95% CI 0.88, 1.01 in men). Thus, our study does not support a causal effect of circulating adiponectin on colorectal cancer risk. Due to the limited genetic determination of adiponectin, larger Mendelian Randomization studies are necessary to clarify whether adiponectin is causally related to lower risk of colorectal cancer.
DOI: 10.1007/s10654-017-0262-y
PubMed: 28550647
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer: a Mendelian Randomization analysis using data from three large cohort studies.</title><author><name sortKey="Nimptsch, Katharina" sort="Nimptsch, Katharina" uniqKey="Nimptsch K" first="Katharina" last="Nimptsch">Katharina Nimptsch</name><affiliation><nlm:affiliation>Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Robert-Rössle-Straße 10, 13125, Berlin, Germany. katharina.nimptsch@mdc-berlin.de.</nlm:affiliation></affiliation></author><author><name sortKey="Song, Mingyang" sort="Song, Mingyang" uniqKey="Song M" first="Mingyang" last="Song">Mingyang Song</name><affiliation><nlm:affiliation>Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Aleksandrova, Krasimira" sort="Aleksandrova, Krasimira" uniqKey="Aleksandrova K" first="Krasimira" last="Aleksandrova">Krasimira Aleksandrova</name><affiliation><nlm:affiliation>Nutrition, Immunity and Metabolism Start-up Lab, Department of Epidemiology, German Institute of Human Nutrition (DIfE), Potsdam-Rehbruecke, Nuthetal, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Katsoulis, Michail" sort="Katsoulis, Michail" uniqKey="Katsoulis M" first="Michail" last="Katsoulis">Michail Katsoulis</name><affiliation><nlm:affiliation>Hellenic Health Foundation, Athens, Greece.</nlm:affiliation></affiliation></author><author><name sortKey="Freisling, Heinz" sort="Freisling, Heinz" uniqKey="Freisling H" first="Heinz" last="Freisling">Heinz Freisling</name><affiliation><nlm:affiliation>International Agency for Research on Cancer (IARC-WHO), Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Jenab, Mazda" sort="Jenab, Mazda" uniqKey="Jenab M" first="Mazda" last="Jenab">Mazda Jenab</name><affiliation><nlm:affiliation>International Agency for Research on Cancer (IARC-WHO), Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gunter, Marc J" sort="Gunter, Marc J" uniqKey="Gunter M" first="Marc J" last="Gunter">Marc J. Gunter</name><affiliation><nlm:affiliation>International Agency for Research on Cancer (IARC-WHO), Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Tsilidis, Konstantinos K" sort="Tsilidis, Konstantinos K" uniqKey="Tsilidis K" first="Konstantinos K" last="Tsilidis">Konstantinos K. Tsilidis</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name><affiliation><nlm:affiliation>Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Bueno De Mesquita, H Bas" sort="Bueno De Mesquita, H Bas" uniqKey="Bueno De Mesquita H" first="H Bas" last="Bueno-De-Mesquita">H Bas Bueno-De-Mesquita</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Chong, Dawn Q" sort="Chong, Dawn Q" uniqKey="Chong D" first="Dawn Q" last="Chong">Dawn Q. Chong</name><affiliation><nlm:affiliation>Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Jensen, Majken K" sort="Jensen, Majken K" uniqKey="Jensen M" first="Majken K" last="Jensen">Majken K. Jensen</name><affiliation><nlm:affiliation>Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wu, Chunsen" sort="Wu, Chunsen" uniqKey="Wu C" first="Chunsen" last="Wu">Chunsen Wu</name><affiliation><nlm:affiliation>Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Overvad, Kim" sort="Overvad, Kim" uniqKey="Overvad K" first="Kim" last="Overvad">Kim Overvad</name><affiliation><nlm:affiliation>Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Kuhn, Tilman" sort="Kuhn, Tilman" uniqKey="Kuhn T" first="Tilman" last="Kühn">Tilman Kühn</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Barrdahl, Myrto" sort="Barrdahl, Myrto" uniqKey="Barrdahl M" first="Myrto" last="Barrdahl">Myrto Barrdahl</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Melander, Olle" sort="Melander, Olle" uniqKey="Melander O" first="Olle" last="Melander">Olle Melander</name><affiliation><nlm:affiliation>Department of Clinical Sciences Lund, Lund University, Malmö, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Jirstrom, Karin" sort="Jirstrom, Karin" uniqKey="Jirstrom K" first="Karin" last="Jirström">Karin Jirström</name><affiliation><nlm:affiliation>Department of Clinical Sciences Lund, Lund University, Malmö, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H" last="Peeters">Petra H. Peeters</name><affiliation><nlm:affiliation>Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Sieri, Sabina" sort="Sieri, Sabina" uniqKey="Sieri S" first="Sabina" last="Sieri">Sabina Sieri</name><affiliation><nlm:affiliation>Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Panico, Salvatore" sort="Panico, Salvatore" uniqKey="Panico S" first="Salvatore" last="Panico">Salvatore Panico</name><affiliation><nlm:affiliation>Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Cross, Amanda J" sort="Cross, Amanda J" uniqKey="Cross A" first="Amanda J" last="Cross">Amanda J. Cross</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Van Guelpen, Bethany" sort="Van Guelpen, Bethany" uniqKey="Van Guelpen B" first="Bethany" last="Van Guelpen">Bethany Van Guelpen</name><affiliation><nlm:affiliation>Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Myte, Robin" sort="Myte, Robin" uniqKey="Myte R" first="Robin" last="Myte">Robin Myte</name><affiliation><nlm:affiliation>Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Huerta, Jose Maria" sort="Huerta, Jose Maria" uniqKey="Huerta J" first="José María" last="Huerta">José María Huerta</name><affiliation><nlm:affiliation>Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Rodriguez Barranco, Miguel" sort="Rodriguez Barranco, Miguel" uniqKey="Rodriguez Barranco M" first="Miguel" last="Rodriguez-Barranco">Miguel Rodriguez-Barranco</name><affiliation><nlm:affiliation>CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Quir S, Jose Ram N" sort="Quir S, Jose Ram N" uniqKey="Quir S J" first="José Ram N" last="Quir S">José Ram N Quir S</name><affiliation><nlm:affiliation>Public Health Directorate, Asturias, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Dorronsoro, Miren" sort="Dorronsoro, Miren" uniqKey="Dorronsoro M" first="Miren" last="Dorronsoro">Miren Dorronsoro</name><affiliation><nlm:affiliation>Public Health Direction and Biodonostia Research Institute- Ciberesp, Basque Regional Health Department, San Sebastian, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Tj Nneland, Anne" sort="Tj Nneland, Anne" uniqKey="Tj Nneland A" first="Anne" last="Tj Nneland">Anne Tj Nneland</name><affiliation><nlm:affiliation>Danish Cancer Society Research Center, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Olsen, Anja" sort="Olsen, Anja" uniqKey="Olsen A" first="Anja" last="Olsen">Anja Olsen</name><affiliation><nlm:affiliation>Danish Cancer Society Research Center, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Travis, Ruth" sort="Travis, Ruth" uniqKey="Travis R" first="Ruth" last="Travis">Ruth Travis</name><affiliation><nlm:affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Boutron Ruault, Marie Christine" sort="Boutron Ruault, Marie Christine" uniqKey="Boutron Ruault M" first="Marie-Christine" last="Boutron-Ruault">Marie-Christine Boutron-Ruault</name><affiliation><nlm:affiliation>Université Paris-Sud, UVSQ, CESP, INSERM, Université Paris-Saclay, Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Carbonnel, Franck" sort="Carbonnel, Franck" uniqKey="Carbonnel F" first="Franck" last="Carbonnel">Franck Carbonnel</name><affiliation><nlm:affiliation>Université Paris-Sud, UVSQ, CESP, INSERM, Université Paris-Saclay, Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:affiliation>Université Paris-Sud, UVSQ, CESP, INSERM, Université Paris-Saclay, Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bonet, Catalina" sort="Bonet, Catalina" uniqKey="Bonet C" first="Catalina" last="Bonet">Catalina Bonet</name><affiliation><nlm:affiliation>Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Palli, Domenico" sort="Palli, Domenico" uniqKey="Palli D" first="Domenico" last="Palli">Domenico Palli</name><affiliation><nlm:affiliation>Cancer Research and Prevention Institute (ISPO), Florence, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Janke, Jurgen" sort="Janke, Jurgen" uniqKey="Janke J" first="Jürgen" last="Janke">Jürgen Janke</name><affiliation><nlm:affiliation>Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Robert-Rössle-Straße 10, 13125, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Young Ae" sort="Lee, Young Ae" uniqKey="Lee Y" first="Young-Ae" last="Lee">Young-Ae Lee</name><affiliation><nlm:affiliation>Genetics of Allergic Disease Research Group, Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name><affiliation><nlm:affiliation>Department of Epidemiology, German Institute of Human Nutrition (DIfE), Potsdam-Rehbruecke, Nuthetal, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L" last="Giovannucci">Edward L. Giovannucci</name><affiliation><nlm:affiliation>Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ogino, Shuji" sort="Ogino, Shuji" uniqKey="Ogino S" first="Shuji" last="Ogino">Shuji Ogino</name><affiliation><nlm:affiliation>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Fuchs, Charles S" sort="Fuchs, Charles S" uniqKey="Fuchs C" first="Charles S" last="Fuchs">Charles S. Fuchs</name><affiliation><nlm:affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Rimm, Eric" sort="Rimm, Eric" uniqKey="Rimm E" first="Eric" last="Rimm">Eric Rimm</name><affiliation><nlm:affiliation>Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wu, Kana" sort="Wu, Kana" uniqKey="Wu K" first="Kana" last="Wu">Kana Wu</name><affiliation><nlm:affiliation>Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T" last="Chan">Andrew T. Chan</name><affiliation><nlm:affiliation>Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Pischon, Tobias" sort="Pischon, Tobias" uniqKey="Pischon T" first="Tobias" last="Pischon">Tobias Pischon</name><affiliation><nlm:affiliation>Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Robert-Rössle-Straße 10, 13125, Berlin, Germany.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28550647</idno><idno type="pmid">28550647</idno><idno type="doi">10.1007/s10654-017-0262-y</idno><idno type="wicri:Area/PubMed/Corpus">000B81</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000B81</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Genetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer: a Mendelian Randomization analysis using data from three large cohort studies.</title><author><name sortKey="Nimptsch, Katharina" sort="Nimptsch, Katharina" uniqKey="Nimptsch K" first="Katharina" last="Nimptsch">Katharina Nimptsch</name><affiliation><nlm:affiliation>Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Robert-Rössle-Straße 10, 13125, Berlin, Germany. katharina.nimptsch@mdc-berlin.de.</nlm:affiliation></affiliation></author><author><name sortKey="Song, Mingyang" sort="Song, Mingyang" uniqKey="Song M" first="Mingyang" last="Song">Mingyang Song</name><affiliation><nlm:affiliation>Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Aleksandrova, Krasimira" sort="Aleksandrova, Krasimira" uniqKey="Aleksandrova K" first="Krasimira" last="Aleksandrova">Krasimira Aleksandrova</name><affiliation><nlm:affiliation>Nutrition, Immunity and Metabolism Start-up Lab, Department of Epidemiology, German Institute of Human Nutrition (DIfE), Potsdam-Rehbruecke, Nuthetal, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Katsoulis, Michail" sort="Katsoulis, Michail" uniqKey="Katsoulis M" first="Michail" last="Katsoulis">Michail Katsoulis</name><affiliation><nlm:affiliation>Hellenic Health Foundation, Athens, Greece.</nlm:affiliation></affiliation></author><author><name sortKey="Freisling, Heinz" sort="Freisling, Heinz" uniqKey="Freisling H" first="Heinz" last="Freisling">Heinz Freisling</name><affiliation><nlm:affiliation>International Agency for Research on Cancer (IARC-WHO), Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Jenab, Mazda" sort="Jenab, Mazda" uniqKey="Jenab M" first="Mazda" last="Jenab">Mazda Jenab</name><affiliation><nlm:affiliation>International Agency for Research on Cancer (IARC-WHO), Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gunter, Marc J" sort="Gunter, Marc J" uniqKey="Gunter M" first="Marc J" last="Gunter">Marc J. Gunter</name><affiliation><nlm:affiliation>International Agency for Research on Cancer (IARC-WHO), Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Tsilidis, Konstantinos K" sort="Tsilidis, Konstantinos K" uniqKey="Tsilidis K" first="Konstantinos K" last="Tsilidis">Konstantinos K. Tsilidis</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name><affiliation><nlm:affiliation>Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Bueno De Mesquita, H Bas" sort="Bueno De Mesquita, H Bas" uniqKey="Bueno De Mesquita H" first="H Bas" last="Bueno-De-Mesquita">H Bas Bueno-De-Mesquita</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Chong, Dawn Q" sort="Chong, Dawn Q" uniqKey="Chong D" first="Dawn Q" last="Chong">Dawn Q. Chong</name><affiliation><nlm:affiliation>Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Jensen, Majken K" sort="Jensen, Majken K" uniqKey="Jensen M" first="Majken K" last="Jensen">Majken K. Jensen</name><affiliation><nlm:affiliation>Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wu, Chunsen" sort="Wu, Chunsen" uniqKey="Wu C" first="Chunsen" last="Wu">Chunsen Wu</name><affiliation><nlm:affiliation>Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Overvad, Kim" sort="Overvad, Kim" uniqKey="Overvad K" first="Kim" last="Overvad">Kim Overvad</name><affiliation><nlm:affiliation>Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Kuhn, Tilman" sort="Kuhn, Tilman" uniqKey="Kuhn T" first="Tilman" last="Kühn">Tilman Kühn</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Barrdahl, Myrto" sort="Barrdahl, Myrto" uniqKey="Barrdahl M" first="Myrto" last="Barrdahl">Myrto Barrdahl</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Melander, Olle" sort="Melander, Olle" uniqKey="Melander O" first="Olle" last="Melander">Olle Melander</name><affiliation><nlm:affiliation>Department of Clinical Sciences Lund, Lund University, Malmö, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Jirstrom, Karin" sort="Jirstrom, Karin" uniqKey="Jirstrom K" first="Karin" last="Jirström">Karin Jirström</name><affiliation><nlm:affiliation>Department of Clinical Sciences Lund, Lund University, Malmö, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H" last="Peeters">Petra H. Peeters</name><affiliation><nlm:affiliation>Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Sieri, Sabina" sort="Sieri, Sabina" uniqKey="Sieri S" first="Sabina" last="Sieri">Sabina Sieri</name><affiliation><nlm:affiliation>Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Panico, Salvatore" sort="Panico, Salvatore" uniqKey="Panico S" first="Salvatore" last="Panico">Salvatore Panico</name><affiliation><nlm:affiliation>Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Cross, Amanda J" sort="Cross, Amanda J" uniqKey="Cross A" first="Amanda J" last="Cross">Amanda J. Cross</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Van Guelpen, Bethany" sort="Van Guelpen, Bethany" uniqKey="Van Guelpen B" first="Bethany" last="Van Guelpen">Bethany Van Guelpen</name><affiliation><nlm:affiliation>Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Myte, Robin" sort="Myte, Robin" uniqKey="Myte R" first="Robin" last="Myte">Robin Myte</name><affiliation><nlm:affiliation>Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Huerta, Jose Maria" sort="Huerta, Jose Maria" uniqKey="Huerta J" first="José María" last="Huerta">José María Huerta</name><affiliation><nlm:affiliation>Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Rodriguez Barranco, Miguel" sort="Rodriguez Barranco, Miguel" uniqKey="Rodriguez Barranco M" first="Miguel" last="Rodriguez-Barranco">Miguel Rodriguez-Barranco</name><affiliation><nlm:affiliation>CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Quir S, Jose Ram N" sort="Quir S, Jose Ram N" uniqKey="Quir S J" first="José Ram N" last="Quir S">José Ram N Quir S</name><affiliation><nlm:affiliation>Public Health Directorate, Asturias, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Dorronsoro, Miren" sort="Dorronsoro, Miren" uniqKey="Dorronsoro M" first="Miren" last="Dorronsoro">Miren Dorronsoro</name><affiliation><nlm:affiliation>Public Health Direction and Biodonostia Research Institute- Ciberesp, Basque Regional Health Department, San Sebastian, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Tj Nneland, Anne" sort="Tj Nneland, Anne" uniqKey="Tj Nneland A" first="Anne" last="Tj Nneland">Anne Tj Nneland</name><affiliation><nlm:affiliation>Danish Cancer Society Research Center, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Olsen, Anja" sort="Olsen, Anja" uniqKey="Olsen A" first="Anja" last="Olsen">Anja Olsen</name><affiliation><nlm:affiliation>Danish Cancer Society Research Center, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Travis, Ruth" sort="Travis, Ruth" uniqKey="Travis R" first="Ruth" last="Travis">Ruth Travis</name><affiliation><nlm:affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Boutron Ruault, Marie Christine" sort="Boutron Ruault, Marie Christine" uniqKey="Boutron Ruault M" first="Marie-Christine" last="Boutron-Ruault">Marie-Christine Boutron-Ruault</name><affiliation><nlm:affiliation>Université Paris-Sud, UVSQ, CESP, INSERM, Université Paris-Saclay, Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Carbonnel, Franck" sort="Carbonnel, Franck" uniqKey="Carbonnel F" first="Franck" last="Carbonnel">Franck Carbonnel</name><affiliation><nlm:affiliation>Université Paris-Sud, UVSQ, CESP, INSERM, Université Paris-Saclay, Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:affiliation>Université Paris-Sud, UVSQ, CESP, INSERM, Université Paris-Saclay, Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bonet, Catalina" sort="Bonet, Catalina" uniqKey="Bonet C" first="Catalina" last="Bonet">Catalina Bonet</name><affiliation><nlm:affiliation>Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Palli, Domenico" sort="Palli, Domenico" uniqKey="Palli D" first="Domenico" last="Palli">Domenico Palli</name><affiliation><nlm:affiliation>Cancer Research and Prevention Institute (ISPO), Florence, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Janke, Jurgen" sort="Janke, Jurgen" uniqKey="Janke J" first="Jürgen" last="Janke">Jürgen Janke</name><affiliation><nlm:affiliation>Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Robert-Rössle-Straße 10, 13125, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Young Ae" sort="Lee, Young Ae" uniqKey="Lee Y" first="Young-Ae" last="Lee">Young-Ae Lee</name><affiliation><nlm:affiliation>Genetics of Allergic Disease Research Group, Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name><affiliation><nlm:affiliation>Department of Epidemiology, German Institute of Human Nutrition (DIfE), Potsdam-Rehbruecke, Nuthetal, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L" last="Giovannucci">Edward L. Giovannucci</name><affiliation><nlm:affiliation>Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ogino, Shuji" sort="Ogino, Shuji" uniqKey="Ogino S" first="Shuji" last="Ogino">Shuji Ogino</name><affiliation><nlm:affiliation>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Fuchs, Charles S" sort="Fuchs, Charles S" uniqKey="Fuchs C" first="Charles S" last="Fuchs">Charles S. Fuchs</name><affiliation><nlm:affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Rimm, Eric" sort="Rimm, Eric" uniqKey="Rimm E" first="Eric" last="Rimm">Eric Rimm</name><affiliation><nlm:affiliation>Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wu, Kana" sort="Wu, Kana" uniqKey="Wu K" first="Kana" last="Wu">Kana Wu</name><affiliation><nlm:affiliation>Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T" last="Chan">Andrew T. Chan</name><affiliation><nlm:affiliation>Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Pischon, Tobias" sort="Pischon, Tobias" uniqKey="Pischon T" first="Tobias" last="Pischon">Tobias Pischon</name><affiliation><nlm:affiliation>Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Robert-Rössle-Straße 10, 13125, Berlin, Germany.</nlm:affiliation></affiliation></author></analytic><series><title level="j">European journal of epidemiology</title><idno type="eISSN">1573-7284</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Higher levels of circulating adiponectin have been related to lower risk of colorectal cancer in several prospective cohort studies, but it remains unclear whether this association may be causal. We aimed to improve causal inference in a Mendelian Randomization meta-analysis using nested case-control studies of the European Prospective Investigation into Cancer and Nutrition (EPIC, 623 cases, 623 matched controls), the Health Professionals Follow-up Study (HPFS, 231 cases, 230 controls) and the Nurses' Health Study (NHS, 399 cases, 774 controls) with available data on pre-diagnostic adiponectin concentrations and selected single nucleotide polymorphisms in the ADIPOQ gene. We created an ADIPOQ allele score that explained approximately 3% of the interindividual variation in adiponectin concentrations. The ADIPOQ allele score was not associated with risk of colorectal cancer in logistic regression analyses (pooled OR per score-unit unit 0.97, 95% CI 0.91, 1.04). Genetically determined twofold higher adiponectin was not significantly associated with risk of colorectal cancer using the ADIPOQ allele score as instrumental variable (pooled OR 0.73, 95% CI 0.40, 1.34). In a summary instrumental variable analysis (based on previously published data) with higher statistical power, no association between genetically determined twofold higher adiponectin and risk of colorectal cancer was observed (0.99, 95% CI 0.93, 1.06 in women and 0.94, 95% CI 0.88, 1.01 in men). Thus, our study does not support a causal effect of circulating adiponectin on colorectal cancer risk. Due to the limited genetic determination of adiponectin, larger Mendelian Randomization studies are necessary to clarify whether adiponectin is causally related to lower risk of colorectal cancer.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28550647</PMID><DateCreated><Year>2017</Year><Month>05</Month><Day>27</Day></DateCreated><DateRevised><Year>2017</Year><Month>10</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1573-7284</ISSN><JournalIssue CitedMedium="Internet"><Volume>32</Volume><Issue>5</Issue><PubDate><Year>2017</Year><Month>May</Month></PubDate></JournalIssue><Title>European journal of epidemiology</Title><ISOAbbreviation>Eur. J. Epidemiol.</ISOAbbreviation></Journal><ArticleTitle>Genetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer: a Mendelian Randomization analysis using data from three large cohort studies.</ArticleTitle><Pagination><MedlinePgn>419-430</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s10654-017-0262-y</ELocationID><Abstract><AbstractText>Higher levels of circulating adiponectin have been related to lower risk of colorectal cancer in several prospective cohort studies, but it remains unclear whether this association may be causal. We aimed to improve causal inference in a Mendelian Randomization meta-analysis using nested case-control studies of the European Prospective Investigation into Cancer and Nutrition (EPIC, 623 cases, 623 matched controls), the Health Professionals Follow-up Study (HPFS, 231 cases, 230 controls) and the Nurses' Health Study (NHS, 399 cases, 774 controls) with available data on pre-diagnostic adiponectin concentrations and selected single nucleotide polymorphisms in the ADIPOQ gene. We created an ADIPOQ allele score that explained approximately 3% of the interindividual variation in adiponectin concentrations. The ADIPOQ allele score was not associated with risk of colorectal cancer in logistic regression analyses (pooled OR per score-unit unit 0.97, 95% CI 0.91, 1.04). Genetically determined twofold higher adiponectin was not significantly associated with risk of colorectal cancer using the ADIPOQ allele score as instrumental variable (pooled OR 0.73, 95% CI 0.40, 1.34). In a summary instrumental variable analysis (based on previously published data) with higher statistical power, no association between genetically determined twofold higher adiponectin and risk of colorectal cancer was observed (0.99, 95% CI 0.93, 1.06 in women and 0.94, 95% CI 0.88, 1.01 in men). Thus, our study does not support a causal effect of circulating adiponectin on colorectal cancer risk. Due to the limited genetic determination of adiponectin, larger Mendelian Randomization studies are necessary to clarify whether adiponectin is causally related to lower risk of colorectal cancer.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nimptsch</LastName><ForeName>Katharina</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Robert-Rössle-Straße 10, 13125, Berlin, Germany. katharina.nimptsch@mdc-berlin.de.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. katharina.nimptsch@mdc-berlin.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Song</LastName><ForeName>Mingyang</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aleksandrova</LastName><ForeName>Krasimira</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Nutrition, Immunity and Metabolism Start-up Lab, Department of Epidemiology, German Institute of Human Nutrition (DIfE), Potsdam-Rehbruecke, Nuthetal, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Katsoulis</LastName><ForeName>Michail</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Hellenic Health Foundation, Athens, Greece.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Farr Institute of Health Informatics Research at London, UCL, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Freisling</LastName><ForeName>Heinz</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>International Agency for Research on Cancer (IARC-WHO), Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jenab</LastName><ForeName>Mazda</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>International Agency for Research on Cancer (IARC-WHO), Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gunter</LastName><ForeName>Marc J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>International Agency for Research on Cancer (IARC-WHO), Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tsilidis</LastName><ForeName>Konstantinos K</ForeName><Initials>KK</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weiderpass</LastName><ForeName>Elisabete</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Research, Cancer Registry of Norway, Oslo, Norway.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Samfundet Folkhälsan, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bueno-De-Mesquita</LastName><ForeName>H Bas</ForeName><Initials>HB</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chong</LastName><ForeName>Dawn Q</ForeName><Initials>DQ</Initials><AffiliationInfo><Affiliation>Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jensen</LastName><ForeName>Majken K</ForeName><Initials>MK</Initials><AffiliationInfo><Affiliation>Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Chunsen</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Odense University Hospital, Odense, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Overvad</LastName><ForeName>Kim</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kühn</LastName><ForeName>Tilman</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barrdahl</LastName><ForeName>Myrto</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Melander</LastName><ForeName>Olle</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Department of Clinical Sciences Lund, Lund University, Malmö, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jirström</LastName><ForeName>Karin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Clinical Sciences Lund, Lund University, Malmö, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peeters</LastName><ForeName>Petra H</ForeName><Initials>PH</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sieri</LastName><ForeName>Sabina</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Panico</LastName><ForeName>Salvatore</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cross</LastName><ForeName>Amanda J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Riboli</LastName><ForeName>Elio</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Van Guelpen</LastName><ForeName>Bethany</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Myte</LastName><ForeName>Robin</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huerta</LastName><ForeName>José María</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rodriguez-Barranco</LastName><ForeName>Miguel</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Escuela Andaluza de Salud Pública, Instituto de Investigación Biosanitaria ibs, GRANADA, Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Quirós</LastName><ForeName>José Ramón</ForeName><Initials>JR</Initials><AffiliationInfo><Affiliation>Public Health Directorate, Asturias, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dorronsoro</LastName><ForeName>Miren</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Public Health Direction and Biodonostia Research Institute- Ciberesp, Basque Regional Health Department, San Sebastian, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tjønneland</LastName><ForeName>Anne</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Danish Cancer Society Research Center, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Olsen</LastName><ForeName>Anja</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Danish Cancer Society Research Center, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Travis</LastName><ForeName>Ruth</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boutron-Ruault</LastName><ForeName>Marie-Christine</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Université Paris-Sud, UVSQ, CESP, INSERM, Université Paris-Saclay, Villejuif, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Gustave Roussy, 94805, Villejuif, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carbonnel</LastName><ForeName>Franck</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Université Paris-Sud, UVSQ, CESP, INSERM, Université Paris-Saclay, Villejuif, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Gustave Roussy, 94805, Villejuif, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Gastroenterology, Assistance Publique-Hôpitaux de Paris (AP-HP), University hospitals Paris-Sud, Site de Bicêtre, Paris Sud University, Paris XI, Le Kremlin Bicêtre, Villejuif, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Severi</LastName><ForeName>Gianluca</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Université Paris-Sud, UVSQ, CESP, INSERM, Université Paris-Saclay, Villejuif, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Gustave Roussy, 94805, Villejuif, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Human Genetics Foundation (HuGeF), Turin, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Cancer Council Victoria, Melbourne, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University of Melbourne, Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bonet</LastName><ForeName>Catalina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Palli</LastName><ForeName>Domenico</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Cancer Research and Prevention Institute (ISPO), Florence, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Janke</LastName><ForeName>Jürgen</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Robert-Rössle-Straße 10, 13125, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Young-Ae</ForeName><Initials>YA</Initials><AffiliationInfo><Affiliation>Genetics of Allergic Disease Research Group, Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boeing</LastName><ForeName>Heiner</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, German Institute of Human Nutrition (DIfE), Potsdam-Rehbruecke, Nuthetal, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giovannucci</LastName><ForeName>Edward L</ForeName><Initials>EL</Initials><AffiliationInfo><Affiliation>Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ogino</LastName><ForeName>Shuji</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fuchs</LastName><ForeName>Charles S</ForeName><Initials>CS</Initials><AffiliationInfo><Affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rimm</LastName><ForeName>Eric</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Kana</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chan</LastName><ForeName>Andrew T</ForeName><Initials>AT</Initials><AffiliationInfo><Affiliation>Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Broad Institute, Cambridge, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pischon</LastName><ForeName>Tobias</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Robert-Rössle-Straße 10, 13125, Berlin, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Charité Universitätsmedizin, Berlin, Germany.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R35 CA197735</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P01 CA087969</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 DK043351</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P01 CA055075</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA151993</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA137178</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>K24 DK098311</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UM1 CA186107</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UM1 CA167552</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA049449</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P50 CA127003</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate 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PubStatus="received"><Year>2016</Year><Month>11</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>05</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="pmc-release"><Year>2018</Year><Month>05</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>5</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>5</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>5</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28550647</ArticleId><ArticleId IdType="doi">10.1007/s10654-017-0262-y</ArticleId><ArticleId IdType="pii">10.1007/s10654-017-0262-y</ArticleId><ArticleId IdType="pmc">PMC5535815</ArticleId><ArticleId 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