EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update.
Identifieur interne : 000A68 ( PubMed/Corpus ); précédent : 000A67; suivant : 000A69EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update.
Auteurs : Josef S. Smolen ; Robert Landewé ; Johannes Bijlsma ; Gerd Burmester ; Katerina Chatzidionysiou ; Maxime Dougados ; Jackie Nam ; Sofia Ramiro ; Marieke Voshaar ; Ronald Van Vollenhoven ; Daniel Aletaha ; Martin Aringer ; Maarten Boers ; Chris D. Buckley ; Frank Buttgereit ; Vivian Bykerk ; Mario Cardiel ; Bernard Combe ; Maurizio Cutolo ; Yvonne Van Eijk-Hustings ; Paul Emery ; Axel Finckh ; Cem Gabay ; Juan Gomez-Reino ; Laure Gossec ; Jacques-Eric Gottenberg ; Johanna M W. Hazes ; Tom Huizinga ; Meghna Jani ; Dmitry Karateev ; Marios Kouloumas ; Tore Kvien ; Zhanguo Li ; Xavier Mariette ; Iain Mcinnes ; Eduardo Mysler ; Peter Nash ; Karel Pavelka ; Gyula Po R ; Christophe Richez ; Piet Van Riel ; Andrea Rubbert-Roth ; Kenneth Saag ; Jose Da Silva ; Tanja Stamm ; Tsutomu Takeuchi ; René Westhovens ; Maarten De Wit ; Désirée Van Der HeijdeSource :
- Annals of the rheumatic diseases [ 1468-2060 ] ; 2017.
English descriptors
- KwdEn :
- Antibodies, Monoclonal (therapeutic use), Antirheumatic Agents (therapeutic use), Arthritis, Rheumatoid (drug therapy), Drug Substitution, Drug Therapy, Combination, Glucocorticoids (therapeutic use), Humans, Janus Kinases (antagonists & inhibitors), Methotrexate (therapeutic use), Patient Participation, Protein Kinase Inhibitors (therapeutic use), Time Factors, Tumor Necrosis Factor-alpha (antagonists & inhibitors).
- MESH :
- chemical , antagonists & inhibitors : Janus Kinases, Tumor Necrosis Factor-alpha.
- chemical , therapeutic use : Antibodies, Monoclonal, Antirheumatic Agents, Glucocorticoids, Methotrexate, Protein Kinase Inhibitors.
- drug therapy : Arthritis, Rheumatoid.
- Drug Substitution, Drug Therapy, Combination, Humans, Patient Participation, Time Factors.
Abstract
Recent insights in rheumatoid arthritis (RA) necessitated updating the European League Against Rheumatism (EULAR) RA management recommendations. A large international Task Force based decisions on evidence from 3 systematic literature reviews, developing 4 overarching principles and 12 recommendations (vs 3 and 14, respectively, in 2013). The recommendations address conventional synthetic (cs) disease-modifying antirheumatic drugs (DMARDs) (methotrexate (MTX), leflunomide, sulfasalazine); glucocorticoids (GC); biological (b) DMARDs (tumour necrosis factor (TNF)-inhibitors (adalimumab, certolizumab pegol, etanercept, golimumab, infliximab), abatacept, rituximab, tocilizumab, clazakizumab, sarilumab and sirukumab and biosimilar (bs) DMARDs) and targeted synthetic (ts) DMARDs (Janus kinase (Jak) inhibitors tofacitinib, baricitinib). Monotherapy, combination therapy, treatment strategies (treat-to-target) and the targets of sustained clinical remission (as defined by the American College of Rheumatology-(ACR)-EULAR Boolean or index criteria) or low disease activity are discussed. Cost aspects were taken into consideration. As first strategy, the Task Force recommends MTX (rapid escalation to 25 mg/week) plus short-term GC, aiming at >50% improvement within 3 and target attainment within 6 months. If this fails stratification is recommended. Without unfavourable prognostic markers, switching to-or adding-another csDMARDs (plus short-term GC) is suggested. In the presence of unfavourable prognostic markers (autoantibodies, high disease activity, early erosions, failure of 2 csDMARDs), any bDMARD (current practice) or Jak-inhibitor should be added to the csDMARD. If this fails, any other bDMARD or tsDMARD is recommended. If a patient is in sustained remission, bDMARDs can be tapered. For each recommendation, levels of evidence and Task Force agreement are provided, both mostly very high. These recommendations intend informing rheumatologists, patients, national rheumatology societies, hospital officials, social security agencies and regulators about EULAR's most recent consensus on the management of RA, aimed at attaining best outcomes with current therapies.
DOI: 10.1136/annrheumdis-2016-210715
PubMed: 28264816
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pubmed:28264816Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update.</title><author><name sortKey="Smolen, Josef S" sort="Smolen, Josef S" uniqKey="Smolen J" first="Josef S" last="Smolen">Josef S. Smolen</name><affiliation><nlm:affiliation>Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Landewe, Robert" sort="Landewe, Robert" uniqKey="Landewe R" first="Robert" last="Landewé">Robert Landewé</name><affiliation><nlm:affiliation>Amsterdam Rheumatology & Immunology Center, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Bijlsma, Johannes" sort="Bijlsma, Johannes" uniqKey="Bijlsma J" first="Johannes" last="Bijlsma">Johannes Bijlsma</name><affiliation><nlm:affiliation>Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Burmester, Gerd" sort="Burmester, Gerd" uniqKey="Burmester G" first="Gerd" last="Burmester">Gerd Burmester</name><affiliation><nlm:affiliation>Department of Rheumatology and Clinical Immunology, Charité-University Medicine Berlin, Free University and Humboldt University Berlin, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Chatzidionysiou, Katerina" sort="Chatzidionysiou, Katerina" uniqKey="Chatzidionysiou K" first="Katerina" last="Chatzidionysiou">Katerina Chatzidionysiou</name><affiliation><nlm:affiliation>Rheumatology Department, Karolinska Institute, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Dougados, Maxime" sort="Dougados, Maxime" uniqKey="Dougados M" first="Maxime" last="Dougados">Maxime Dougados</name><affiliation><nlm:affiliation>Rhumatologie B, Hopital Cochin, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Nam, Jackie" sort="Nam, Jackie" uniqKey="Nam J" first="Jackie" last="Nam">Jackie Nam</name><affiliation><nlm:affiliation>NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Ramiro, Sofia" sort="Ramiro, Sofia" uniqKey="Ramiro S" first="Sofia" last="Ramiro">Sofia Ramiro</name><affiliation><nlm:affiliation>Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Voshaar, Marieke" sort="Voshaar, Marieke" uniqKey="Voshaar M" first="Marieke" last="Voshaar">Marieke Voshaar</name><affiliation><nlm:affiliation>Department of Psychology, Health and Technology, University of Twente, Enschede, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Van Vollenhoven, Ronald" sort="Van Vollenhoven, Ronald" uniqKey="Van Vollenhoven R" first="Ronald" last="Van Vollenhoven">Ronald Van Vollenhoven</name><affiliation><nlm:affiliation>Amsterdam Rheumatology & Immunology Center, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Aletaha, Daniel" sort="Aletaha, Daniel" uniqKey="Aletaha D" first="Daniel" last="Aletaha">Daniel Aletaha</name><affiliation><nlm:affiliation>Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Aringer, Martin" sort="Aringer, Martin" uniqKey="Aringer M" first="Martin" last="Aringer">Martin Aringer</name><affiliation><nlm:affiliation>Division of Rheumatology, Medizinische Klinik und Poliklinik III, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Boers, Maarten" sort="Boers, Maarten" uniqKey="Boers M" first="Maarten" last="Boers">Maarten Boers</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Buckley, Chris D" sort="Buckley, Chris D" uniqKey="Buckley C" first="Chris D" last="Buckley">Chris D. Buckley</name><affiliation><nlm:affiliation>Birmingham NIHR Wellcome Trust Clinical Research Facility, Rheumatology Research Group, Institute of Inflammation and Ageing (IIA), University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Buttgereit, Frank" sort="Buttgereit, Frank" uniqKey="Buttgereit F" first="Frank" last="Buttgereit">Frank Buttgereit</name><affiliation><nlm:affiliation>Department of Rheumatology and Clinical Immunology, Charité-University Medicine Berlin, Free University and Humboldt University Berlin, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Bykerk, Vivian" sort="Bykerk, Vivian" uniqKey="Bykerk V" first="Vivian" last="Bykerk">Vivian Bykerk</name><affiliation><nlm:affiliation>Department of Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Cardiel, Mario" sort="Cardiel, Mario" uniqKey="Cardiel M" first="Mario" last="Cardiel">Mario Cardiel</name><affiliation><nlm:affiliation>Centro de Investigación Clínica de Morelia SC, Michoacán, México.</nlm:affiliation></affiliation></author><author><name sortKey="Combe, Bernard" sort="Combe, Bernard" uniqKey="Combe B" first="Bernard" last="Combe">Bernard Combe</name><affiliation><nlm:affiliation>Rheumatology Department, Lapeyronie Hospital, Montpellier University, UMR 5535, Montpellier, France.</nlm:affiliation></affiliation></author><author><name sortKey="Cutolo, Maurizio" sort="Cutolo, Maurizio" uniqKey="Cutolo M" first="Maurizio" last="Cutolo">Maurizio Cutolo</name><affiliation><nlm:affiliation>Research Laboratory and Division of Clinical Rheumatology, University of Genoa, Genoa, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Van Eijk Hustings, Yvonne" sort="Van Eijk Hustings, Yvonne" uniqKey="Van Eijk Hustings Y" first="Yvonne" last="Van Eijk-Hustings">Yvonne Van Eijk-Hustings</name><affiliation><nlm:affiliation>Department of Patient & Care and Department of Rheumatology, University of Maastricht, Maastricht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Emery, Paul" sort="Emery, Paul" uniqKey="Emery P" first="Paul" last="Emery">Paul Emery</name><affiliation><nlm:affiliation>Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Finckh, Axel" sort="Finckh, Axel" uniqKey="Finckh A" first="Axel" last="Finckh">Axel Finckh</name><affiliation><nlm:affiliation>Division of Rheumatology, University Hospitals of Geneva, Geneva, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Gabay, Cem" sort="Gabay, Cem" uniqKey="Gabay C" first="Cem" last="Gabay">Cem Gabay</name><affiliation><nlm:affiliation>Division of Rheumatology, University Hospitals of Geneva, Geneva, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Gomez Reino, Juan" sort="Gomez Reino, Juan" uniqKey="Gomez Reino J" first="Juan" last="Gomez-Reino">Juan Gomez-Reino</name><affiliation><nlm:affiliation>Fundación Ramón Dominguez, Hospital Clinico Universitario, Santiago, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Gossec, Laure" sort="Gossec, Laure" uniqKey="Gossec L" first="Laure" last="Gossec">Laure Gossec</name><affiliation><nlm:affiliation>Department of Rheumatology, Sorbonne Universités, Pitié Salpêtrière Hospital, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gottenberg, Jacques Eric" sort="Gottenberg, Jacques Eric" uniqKey="Gottenberg J" first="Jacques-Eric" last="Gottenberg">Jacques-Eric Gottenberg</name><affiliation><nlm:affiliation>Institut de Biologie Moléculaire et Cellulaire, Immunopathologie, et Chimie Thérapeutique, Strasbourg University Hospital and University of Strasbourg, CNRS, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Hazes, Johanna M W" sort="Hazes, Johanna M W" uniqKey="Hazes J" first="Johanna M W" last="Hazes">Johanna M W. Hazes</name><affiliation><nlm:affiliation>Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Huizinga, Tom" sort="Huizinga, Tom" uniqKey="Huizinga T" first="Tom" last="Huizinga">Tom Huizinga</name><affiliation><nlm:affiliation>Department of Psychology, Health and Technology, University of Twente, Enschede, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Jani, Meghna" sort="Jani, Meghna" uniqKey="Jani M" first="Meghna" last="Jani">Meghna Jani</name><affiliation><nlm:affiliation>Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, University of Manchester, Manchester, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Karateev, Dmitry" sort="Karateev, Dmitry" uniqKey="Karateev D" first="Dmitry" last="Karateev">Dmitry Karateev</name><affiliation><nlm:affiliation>V.A. Nasonova Research Institute of Rheumatology, Moscow, Russian Federation.</nlm:affiliation></affiliation></author><author><name sortKey="Kouloumas, Marios" sort="Kouloumas, Marios" uniqKey="Kouloumas M" first="Marios" last="Kouloumas">Marios Kouloumas</name><affiliation><nlm:affiliation>European League Against Rheumatism, Zurich, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Kvien, Tore" sort="Kvien, Tore" uniqKey="Kvien T" first="Tore" last="Kvien">Tore Kvien</name><affiliation><nlm:affiliation>Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Zhanguo" sort="Li, Zhanguo" uniqKey="Li Z" first="Zhanguo" last="Li">Zhanguo Li</name><affiliation><nlm:affiliation>Department of Rheumatology and Immunology, Beijing University People's Hospital, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name><affiliation><nlm:affiliation>Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Université Paris-Sud, INSERM U1184, Center for Immunology of viral Infections and Autoimmune Diseases (IMVA), Le Kremlin Bicêtre, France.</nlm:affiliation></affiliation></author><author><name sortKey="Mcinnes, Iain" sort="Mcinnes, Iain" uniqKey="Mcinnes I" first="Iain" last="Mcinnes">Iain Mcinnes</name><affiliation><nlm:affiliation>Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Mysler, Eduardo" sort="Mysler, Eduardo" uniqKey="Mysler E" first="Eduardo" last="Mysler">Eduardo Mysler</name><affiliation><nlm:affiliation>Organización Médica de Investigación, Buenos Aires, Argentina.</nlm:affiliation></affiliation></author><author><name sortKey="Nash, Peter" sort="Nash, Peter" uniqKey="Nash P" first="Peter" last="Nash">Peter Nash</name><affiliation><nlm:affiliation>Department of Medicine, University of Queensland, Queensland, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Pavelka, Karel" sort="Pavelka, Karel" uniqKey="Pavelka K" first="Karel" last="Pavelka">Karel Pavelka</name><affiliation><nlm:affiliation>Institute of Rheumatology and Clinic of Rheumatology, Charles University, Prague, Czech Republic.</nlm:affiliation></affiliation></author><author><name sortKey="Po R, Gyula" sort="Po R, Gyula" uniqKey="Po R G" first="Gyula" last="Po R">Gyula Po R</name><affiliation><nlm:affiliation>National Institute of Rheumatology and Physiotherapy, Semmelweis University, Budapest, Hungary.</nlm:affiliation></affiliation></author><author><name sortKey="Richez, Christophe" sort="Richez, Christophe" uniqKey="Richez C" first="Christophe" last="Richez">Christophe Richez</name><affiliation><nlm:affiliation>Rheumatology Department, FHU ACRONIM, Pellegrin Hospital and UMR CNRS 5164, Bordeaux University, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Van Riel, Piet" sort="Van Riel, Piet" uniqKey="Van Riel P" first="Piet" last="Van Riel">Piet Van Riel</name><affiliation><nlm:affiliation>Department of Rheumatology, Bernhoven, Uden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Rubbert Roth, Andrea" sort="Rubbert Roth, Andrea" uniqKey="Rubbert Roth A" first="Andrea" last="Rubbert-Roth">Andrea Rubbert-Roth</name><affiliation><nlm:affiliation>University of Cologne, Cologne, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Saag, Kenneth" sort="Saag, Kenneth" uniqKey="Saag K" first="Kenneth" last="Saag">Kenneth Saag</name><affiliation><nlm:affiliation>Division of Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Da Silva, Jose" sort="Da Silva, Jose" uniqKey="Da Silva J" first="Jose" last="Da Silva">Jose Da Silva</name><affiliation><nlm:affiliation>Serviço de Reumatologia, Centro Hospitalar e Universitário de Coimbra Praceta Mota Pinto, Coimbra, Portugal.</nlm:affiliation></affiliation></author><author><name sortKey="Stamm, Tanja" sort="Stamm, Tanja" uniqKey="Stamm T" first="Tanja" last="Stamm">Tanja Stamm</name><affiliation><nlm:affiliation>Section for Outcomes Research, Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Takeuchi, Tsutomu" sort="Takeuchi, Tsutomu" uniqKey="Takeuchi T" first="Tsutomu" last="Takeuchi">Tsutomu Takeuchi</name><affiliation><nlm:affiliation>Keio University School of Medicine, Keio University Hospital, Tokyo, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Westhovens, Rene" sort="Westhovens, Rene" uniqKey="Westhovens R" first="René" last="Westhovens">René Westhovens</name><affiliation><nlm:affiliation>Department of Development and Regeneration, Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="De Wit, Maarten" sort="De Wit, Maarten" uniqKey="De Wit M" first="Maarten" last="De Wit">Maarten De Wit</name><affiliation><nlm:affiliation>Department Medical Humanities, VU Medical Centre, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Van Der Heijde, Desiree" sort="Van Der Heijde, Desiree" uniqKey="Van Der Heijde D" first="Désirée" last="Van Der Heijde">Désirée Van Der Heijde</name><affiliation><nlm:affiliation>Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28264816</idno><idno type="pmid">28264816</idno><idno type="doi">10.1136/annrheumdis-2016-210715</idno><idno type="wicri:Area/PubMed/Corpus">000A68</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A68</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update.</title><author><name sortKey="Smolen, Josef S" sort="Smolen, Josef S" uniqKey="Smolen J" first="Josef S" last="Smolen">Josef S. Smolen</name><affiliation><nlm:affiliation>Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Landewe, Robert" sort="Landewe, Robert" uniqKey="Landewe R" first="Robert" last="Landewé">Robert Landewé</name><affiliation><nlm:affiliation>Amsterdam Rheumatology & Immunology Center, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Bijlsma, Johannes" sort="Bijlsma, Johannes" uniqKey="Bijlsma J" first="Johannes" last="Bijlsma">Johannes Bijlsma</name><affiliation><nlm:affiliation>Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Burmester, Gerd" sort="Burmester, Gerd" uniqKey="Burmester G" first="Gerd" last="Burmester">Gerd Burmester</name><affiliation><nlm:affiliation>Department of Rheumatology and Clinical Immunology, Charité-University Medicine Berlin, Free University and Humboldt University Berlin, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Chatzidionysiou, Katerina" sort="Chatzidionysiou, Katerina" uniqKey="Chatzidionysiou K" first="Katerina" last="Chatzidionysiou">Katerina Chatzidionysiou</name><affiliation><nlm:affiliation>Rheumatology Department, Karolinska Institute, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Dougados, Maxime" sort="Dougados, Maxime" uniqKey="Dougados M" first="Maxime" last="Dougados">Maxime Dougados</name><affiliation><nlm:affiliation>Rhumatologie B, Hopital Cochin, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Nam, Jackie" sort="Nam, Jackie" uniqKey="Nam J" first="Jackie" last="Nam">Jackie Nam</name><affiliation><nlm:affiliation>NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Ramiro, Sofia" sort="Ramiro, Sofia" uniqKey="Ramiro S" first="Sofia" last="Ramiro">Sofia Ramiro</name><affiliation><nlm:affiliation>Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Voshaar, Marieke" sort="Voshaar, Marieke" uniqKey="Voshaar M" first="Marieke" last="Voshaar">Marieke Voshaar</name><affiliation><nlm:affiliation>Department of Psychology, Health and Technology, University of Twente, Enschede, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Van Vollenhoven, Ronald" sort="Van Vollenhoven, Ronald" uniqKey="Van Vollenhoven R" first="Ronald" last="Van Vollenhoven">Ronald Van Vollenhoven</name><affiliation><nlm:affiliation>Amsterdam Rheumatology & Immunology Center, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Aletaha, Daniel" sort="Aletaha, Daniel" uniqKey="Aletaha D" first="Daniel" last="Aletaha">Daniel Aletaha</name><affiliation><nlm:affiliation>Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Aringer, Martin" sort="Aringer, Martin" uniqKey="Aringer M" first="Martin" last="Aringer">Martin Aringer</name><affiliation><nlm:affiliation>Division of Rheumatology, Medizinische Klinik und Poliklinik III, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Boers, Maarten" sort="Boers, Maarten" uniqKey="Boers M" first="Maarten" last="Boers">Maarten Boers</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Buckley, Chris D" sort="Buckley, Chris D" uniqKey="Buckley C" first="Chris D" last="Buckley">Chris D. Buckley</name><affiliation><nlm:affiliation>Birmingham NIHR Wellcome Trust Clinical Research Facility, Rheumatology Research Group, Institute of Inflammation and Ageing (IIA), University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Buttgereit, Frank" sort="Buttgereit, Frank" uniqKey="Buttgereit F" first="Frank" last="Buttgereit">Frank Buttgereit</name><affiliation><nlm:affiliation>Department of Rheumatology and Clinical Immunology, Charité-University Medicine Berlin, Free University and Humboldt University Berlin, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Bykerk, Vivian" sort="Bykerk, Vivian" uniqKey="Bykerk V" first="Vivian" last="Bykerk">Vivian Bykerk</name><affiliation><nlm:affiliation>Department of Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Cardiel, Mario" sort="Cardiel, Mario" uniqKey="Cardiel M" first="Mario" last="Cardiel">Mario Cardiel</name><affiliation><nlm:affiliation>Centro de Investigación Clínica de Morelia SC, Michoacán, México.</nlm:affiliation></affiliation></author><author><name sortKey="Combe, Bernard" sort="Combe, Bernard" uniqKey="Combe B" first="Bernard" last="Combe">Bernard Combe</name><affiliation><nlm:affiliation>Rheumatology Department, Lapeyronie Hospital, Montpellier University, UMR 5535, Montpellier, France.</nlm:affiliation></affiliation></author><author><name sortKey="Cutolo, Maurizio" sort="Cutolo, Maurizio" uniqKey="Cutolo M" first="Maurizio" last="Cutolo">Maurizio Cutolo</name><affiliation><nlm:affiliation>Research Laboratory and Division of Clinical Rheumatology, University of Genoa, Genoa, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Van Eijk Hustings, Yvonne" sort="Van Eijk Hustings, Yvonne" uniqKey="Van Eijk Hustings Y" first="Yvonne" last="Van Eijk-Hustings">Yvonne Van Eijk-Hustings</name><affiliation><nlm:affiliation>Department of Patient & Care and Department of Rheumatology, University of Maastricht, Maastricht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Emery, Paul" sort="Emery, Paul" uniqKey="Emery P" first="Paul" last="Emery">Paul Emery</name><affiliation><nlm:affiliation>Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Finckh, Axel" sort="Finckh, Axel" uniqKey="Finckh A" first="Axel" last="Finckh">Axel Finckh</name><affiliation><nlm:affiliation>Division of Rheumatology, University Hospitals of Geneva, Geneva, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Gabay, Cem" sort="Gabay, Cem" uniqKey="Gabay C" first="Cem" last="Gabay">Cem Gabay</name><affiliation><nlm:affiliation>Division of Rheumatology, University Hospitals of Geneva, Geneva, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Gomez Reino, Juan" sort="Gomez Reino, Juan" uniqKey="Gomez Reino J" first="Juan" last="Gomez-Reino">Juan Gomez-Reino</name><affiliation><nlm:affiliation>Fundación Ramón Dominguez, Hospital Clinico Universitario, Santiago, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Gossec, Laure" sort="Gossec, Laure" uniqKey="Gossec L" first="Laure" last="Gossec">Laure Gossec</name><affiliation><nlm:affiliation>Department of Rheumatology, Sorbonne Universités, Pitié Salpêtrière Hospital, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gottenberg, Jacques Eric" sort="Gottenberg, Jacques Eric" uniqKey="Gottenberg J" first="Jacques-Eric" last="Gottenberg">Jacques-Eric Gottenberg</name><affiliation><nlm:affiliation>Institut de Biologie Moléculaire et Cellulaire, Immunopathologie, et Chimie Thérapeutique, Strasbourg University Hospital and University of Strasbourg, CNRS, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Hazes, Johanna M W" sort="Hazes, Johanna M W" uniqKey="Hazes J" first="Johanna M W" last="Hazes">Johanna M W. Hazes</name><affiliation><nlm:affiliation>Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Huizinga, Tom" sort="Huizinga, Tom" uniqKey="Huizinga T" first="Tom" last="Huizinga">Tom Huizinga</name><affiliation><nlm:affiliation>Department of Psychology, Health and Technology, University of Twente, Enschede, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Jani, Meghna" sort="Jani, Meghna" uniqKey="Jani M" first="Meghna" last="Jani">Meghna Jani</name><affiliation><nlm:affiliation>Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, University of Manchester, Manchester, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Karateev, Dmitry" sort="Karateev, Dmitry" uniqKey="Karateev D" first="Dmitry" last="Karateev">Dmitry Karateev</name><affiliation><nlm:affiliation>V.A. Nasonova Research Institute of Rheumatology, Moscow, Russian Federation.</nlm:affiliation></affiliation></author><author><name sortKey="Kouloumas, Marios" sort="Kouloumas, Marios" uniqKey="Kouloumas M" first="Marios" last="Kouloumas">Marios Kouloumas</name><affiliation><nlm:affiliation>European League Against Rheumatism, Zurich, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Kvien, Tore" sort="Kvien, Tore" uniqKey="Kvien T" first="Tore" last="Kvien">Tore Kvien</name><affiliation><nlm:affiliation>Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Zhanguo" sort="Li, Zhanguo" uniqKey="Li Z" first="Zhanguo" last="Li">Zhanguo Li</name><affiliation><nlm:affiliation>Department of Rheumatology and Immunology, Beijing University People's Hospital, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name><affiliation><nlm:affiliation>Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Université Paris-Sud, INSERM U1184, Center for Immunology of viral Infections and Autoimmune Diseases (IMVA), Le Kremlin Bicêtre, France.</nlm:affiliation></affiliation></author><author><name sortKey="Mcinnes, Iain" sort="Mcinnes, Iain" uniqKey="Mcinnes I" first="Iain" last="Mcinnes">Iain Mcinnes</name><affiliation><nlm:affiliation>Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Mysler, Eduardo" sort="Mysler, Eduardo" uniqKey="Mysler E" first="Eduardo" last="Mysler">Eduardo Mysler</name><affiliation><nlm:affiliation>Organización Médica de Investigación, Buenos Aires, Argentina.</nlm:affiliation></affiliation></author><author><name sortKey="Nash, Peter" sort="Nash, Peter" uniqKey="Nash P" first="Peter" last="Nash">Peter Nash</name><affiliation><nlm:affiliation>Department of Medicine, University of Queensland, Queensland, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Pavelka, Karel" sort="Pavelka, Karel" uniqKey="Pavelka K" first="Karel" last="Pavelka">Karel Pavelka</name><affiliation><nlm:affiliation>Institute of Rheumatology and Clinic of Rheumatology, Charles University, Prague, Czech Republic.</nlm:affiliation></affiliation></author><author><name sortKey="Po R, Gyula" sort="Po R, Gyula" uniqKey="Po R G" first="Gyula" last="Po R">Gyula Po R</name><affiliation><nlm:affiliation>National Institute of Rheumatology and Physiotherapy, Semmelweis University, Budapest, Hungary.</nlm:affiliation></affiliation></author><author><name sortKey="Richez, Christophe" sort="Richez, Christophe" uniqKey="Richez C" first="Christophe" last="Richez">Christophe Richez</name><affiliation><nlm:affiliation>Rheumatology Department, FHU ACRONIM, Pellegrin Hospital and UMR CNRS 5164, Bordeaux University, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Van Riel, Piet" sort="Van Riel, Piet" uniqKey="Van Riel P" first="Piet" last="Van Riel">Piet Van Riel</name><affiliation><nlm:affiliation>Department of Rheumatology, Bernhoven, Uden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Rubbert Roth, Andrea" sort="Rubbert Roth, Andrea" uniqKey="Rubbert Roth A" first="Andrea" last="Rubbert-Roth">Andrea Rubbert-Roth</name><affiliation><nlm:affiliation>University of Cologne, Cologne, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Saag, Kenneth" sort="Saag, Kenneth" uniqKey="Saag K" first="Kenneth" last="Saag">Kenneth Saag</name><affiliation><nlm:affiliation>Division of Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Da Silva, Jose" sort="Da Silva, Jose" uniqKey="Da Silva J" first="Jose" last="Da Silva">Jose Da Silva</name><affiliation><nlm:affiliation>Serviço de Reumatologia, Centro Hospitalar e Universitário de Coimbra Praceta Mota Pinto, Coimbra, Portugal.</nlm:affiliation></affiliation></author><author><name sortKey="Stamm, Tanja" sort="Stamm, Tanja" uniqKey="Stamm T" first="Tanja" last="Stamm">Tanja Stamm</name><affiliation><nlm:affiliation>Section for Outcomes Research, Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Takeuchi, Tsutomu" sort="Takeuchi, Tsutomu" uniqKey="Takeuchi T" first="Tsutomu" last="Takeuchi">Tsutomu Takeuchi</name><affiliation><nlm:affiliation>Keio University School of Medicine, Keio University Hospital, Tokyo, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Westhovens, Rene" sort="Westhovens, Rene" uniqKey="Westhovens R" first="René" last="Westhovens">René Westhovens</name><affiliation><nlm:affiliation>Department of Development and Regeneration, Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="De Wit, Maarten" sort="De Wit, Maarten" uniqKey="De Wit M" first="Maarten" last="De Wit">Maarten De Wit</name><affiliation><nlm:affiliation>Department Medical Humanities, VU Medical Centre, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Van Der Heijde, Desiree" sort="Van Der Heijde, Desiree" uniqKey="Van Der Heijde D" first="Désirée" last="Van Der Heijde">Désirée Van Der Heijde</name><affiliation><nlm:affiliation>Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Annals of the rheumatic diseases</title><idno type="eISSN">1468-2060</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibodies, Monoclonal (therapeutic use)</term><term>Antirheumatic Agents (therapeutic use)</term><term>Arthritis, Rheumatoid (drug therapy)</term><term>Drug Substitution</term><term>Drug Therapy, Combination</term><term>Glucocorticoids (therapeutic use)</term><term>Humans</term><term>Janus Kinases (antagonists & inhibitors)</term><term>Methotrexate (therapeutic use)</term><term>Patient Participation</term><term>Protein Kinase Inhibitors (therapeutic use)</term><term>Time Factors</term><term>Tumor Necrosis Factor-alpha (antagonists & inhibitors)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Janus Kinases</term><term>Tumor Necrosis Factor-alpha</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Antirheumatic Agents</term><term>Glucocorticoids</term><term>Methotrexate</term><term>Protein Kinase Inhibitors</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Arthritis, Rheumatoid</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Drug Substitution</term><term>Drug Therapy, Combination</term><term>Humans</term><term>Patient Participation</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recent insights in rheumatoid arthritis (RA) necessitated updating the European League Against Rheumatism (EULAR) RA management recommendations. A large international Task Force based decisions on evidence from 3 systematic literature reviews, developing 4 overarching principles and 12 recommendations (vs 3 and 14, respectively, in 2013). The recommendations address conventional synthetic (cs) disease-modifying antirheumatic drugs (DMARDs) (methotrexate (MTX), leflunomide, sulfasalazine); glucocorticoids (GC); biological (b) DMARDs (tumour necrosis factor (TNF)-inhibitors (adalimumab, certolizumab pegol, etanercept, golimumab, infliximab), abatacept, rituximab, tocilizumab, clazakizumab, sarilumab and sirukumab and biosimilar (bs) DMARDs) and targeted synthetic (ts) DMARDs (Janus kinase (Jak) inhibitors tofacitinib, baricitinib). Monotherapy, combination therapy, treatment strategies (treat-to-target) and the targets of sustained clinical remission (as defined by the American College of Rheumatology-(ACR)-EULAR Boolean or index criteria) or low disease activity are discussed. Cost aspects were taken into consideration. As first strategy, the Task Force recommends MTX (rapid escalation to 25 mg/week) plus short-term GC, aiming at >50% improvement within 3 and target attainment within 6 months. If this fails stratification is recommended. Without unfavourable prognostic markers, switching to-or adding-another csDMARDs (plus short-term GC) is suggested. In the presence of unfavourable prognostic markers (autoantibodies, high disease activity, early erosions, failure of 2 csDMARDs), any bDMARD (current practice) or Jak-inhibitor should be added to the csDMARD. If this fails, any other bDMARD or tsDMARD is recommended. If a patient is in sustained remission, bDMARDs can be tapered. For each recommendation, levels of evidence and Task Force agreement are provided, both mostly very high. These recommendations intend informing rheumatologists, patients, national rheumatology societies, hospital officials, social security agencies and regulators about EULAR's most recent consensus on the management of RA, aimed at attaining best outcomes with current therapies.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28264816</PMID><DateCreated><Year>2017</Year><Month>03</Month><Day>07</Day></DateCreated><DateCompleted><Year>2017</Year><Month>08</Month><Day>14</Day></DateCompleted><DateRevised><Year>2017</Year><Month>08</Month><Day>14</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1468-2060</ISSN><JournalIssue CitedMedium="Internet"><Volume>76</Volume><Issue>6</Issue><PubDate><Year>2017</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Annals of the rheumatic diseases</Title><ISOAbbreviation>Ann. Rheum. Dis.</ISOAbbreviation></Journal><ArticleTitle>EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update.</ArticleTitle><Pagination><MedlinePgn>960-977</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1136/annrheumdis-2016-210715</ELocationID><Abstract><AbstractText>Recent insights in rheumatoid arthritis (RA) necessitated updating the European League Against Rheumatism (EULAR) RA management recommendations. A large international Task Force based decisions on evidence from 3 systematic literature reviews, developing 4 overarching principles and 12 recommendations (vs 3 and 14, respectively, in 2013). The recommendations address conventional synthetic (cs) disease-modifying antirheumatic drugs (DMARDs) (methotrexate (MTX), leflunomide, sulfasalazine); glucocorticoids (GC); biological (b) DMARDs (tumour necrosis factor (TNF)-inhibitors (adalimumab, certolizumab pegol, etanercept, golimumab, infliximab), abatacept, rituximab, tocilizumab, clazakizumab, sarilumab and sirukumab and biosimilar (bs) DMARDs) and targeted synthetic (ts) DMARDs (Janus kinase (Jak) inhibitors tofacitinib, baricitinib). Monotherapy, combination therapy, treatment strategies (treat-to-target) and the targets of sustained clinical remission (as defined by the American College of Rheumatology-(ACR)-EULAR Boolean or index criteria) or low disease activity are discussed. Cost aspects were taken into consideration. As first strategy, the Task Force recommends MTX (rapid escalation to 25 mg/week) plus short-term GC, aiming at >50% improvement within 3 and target attainment within 6 months. If this fails stratification is recommended. Without unfavourable prognostic markers, switching to-or adding-another csDMARDs (plus short-term GC) is suggested. In the presence of unfavourable prognostic markers (autoantibodies, high disease activity, early erosions, failure of 2 csDMARDs), any bDMARD (current practice) or Jak-inhibitor should be added to the csDMARD. If this fails, any other bDMARD or tsDMARD is recommended. If a patient is in sustained remission, bDMARDs can be tapered. For each recommendation, levels of evidence and Task Force agreement are provided, both mostly very high. These recommendations intend informing rheumatologists, patients, national rheumatology societies, hospital officials, social security agencies and regulators about EULAR's most recent consensus on the management of RA, aimed at attaining best outcomes with current therapies.</AbstractText><CopyrightInformation>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Smolen</LastName><ForeName>Josef S</ForeName><Initials>JS</Initials><AffiliationInfo><Affiliation>Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>2nd Department of Medicine, Hietzing Hospital, Vienna, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Landewé</LastName><ForeName>Robert</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Amsterdam Rheumatology & Immunology Center, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Zuyderland Medical Center, Heerlen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bijlsma</LastName><ForeName>Johannes</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Burmester</LastName><ForeName>Gerd</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Clinical Immunology, Charité-University Medicine Berlin, Free University and Humboldt University Berlin, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chatzidionysiou</LastName><ForeName>Katerina</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Rheumatology Department, Karolinska Institute, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dougados</LastName><ForeName>Maxime</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Rhumatologie B, Hopital Cochin, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nam</LastName><ForeName>Jackie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ramiro</LastName><ForeName>Sofia</ForeName><Initials>S</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-8899-9087</Identifier><AffiliationInfo><Affiliation>Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Voshaar</LastName><ForeName>Marieke</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Psychology, Health and Technology, University of Twente, Enschede, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Vollenhoven</LastName><ForeName>Ronald</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Amsterdam Rheumatology & Immunology Center, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Zuyderland Medical Center, Heerlen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aletaha</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aringer</LastName><ForeName>Martin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Rheumatology, Medizinische Klinik und Poliklinik III, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boers</LastName><ForeName>Maarten</ForeName><Initials>M</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-6969-283X</Identifier><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Buckley</LastName><ForeName>Chris D</ForeName><Initials>CD</Initials><AffiliationInfo><Affiliation>Birmingham NIHR Wellcome Trust Clinical Research Facility, Rheumatology Research Group, Institute of Inflammation and Ageing (IIA), University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Buttgereit</LastName><ForeName>Frank</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Clinical Immunology, Charité-University Medicine Berlin, Free University and Humboldt University Berlin, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bykerk</LastName><ForeName>Vivian</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, New York, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Rebecca McDonald Center for Arthritis & Autoimmune Disease, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cardiel</LastName><ForeName>Mario</ForeName><Initials>M</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-2731-9180</Identifier><AffiliationInfo><Affiliation>Centro de Investigación Clínica de Morelia SC, Michoacán, México.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Combe</LastName><ForeName>Bernard</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Rheumatology Department, Lapeyronie Hospital, Montpellier University, UMR 5535, Montpellier, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cutolo</LastName><ForeName>Maurizio</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Research Laboratory and Division of Clinical Rheumatology, University of Genoa, Genoa, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Eijk-Hustings</LastName><ForeName>Yvonne</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Patient & Care and Department of Rheumatology, University of Maastricht, Maastricht, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Emery</LastName><ForeName>Paul</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Finckh</LastName><ForeName>Axel</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Division of Rheumatology, University Hospitals of Geneva, Geneva, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gabay</LastName><ForeName>Cem</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Division of Rheumatology, University Hospitals of Geneva, Geneva, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gomez-Reino</LastName><ForeName>Juan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Fundación Ramón Dominguez, Hospital Clinico Universitario, Santiago, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gossec</LastName><ForeName>Laure</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Sorbonne Universités, Pitié Salpêtrière Hospital, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gottenberg</LastName><ForeName>Jacques-Eric</ForeName><Initials>JE</Initials><AffiliationInfo><Affiliation>Institut de Biologie Moléculaire et Cellulaire, Immunopathologie, et Chimie Thérapeutique, Strasbourg University Hospital and University of Strasbourg, CNRS, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hazes</LastName><ForeName>Johanna M W</ForeName><Initials>JMW</Initials><AffiliationInfo><Affiliation>Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huizinga</LastName><ForeName>Tom</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Psychology, Health and Technology, University of Twente, Enschede, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jani</LastName><ForeName>Meghna</ForeName><Initials>M</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-1487-277X</Identifier><AffiliationInfo><Affiliation>Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, University of Manchester, Manchester, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Karateev</LastName><ForeName>Dmitry</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>V.A. Nasonova Research Institute of Rheumatology, Moscow, Russian Federation.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kouloumas</LastName><ForeName>Marios</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>European League Against Rheumatism, Zurich, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Cyprus League against Rheumatism, Nicosia, Cyprus.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kvien</LastName><ForeName>Tore</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Zhanguo</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Immunology, Beijing University People's Hospital, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mariette</LastName><ForeName>Xavier</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Université Paris-Sud, INSERM U1184, Center for Immunology of viral Infections and Autoimmune Diseases (IMVA), Le Kremlin Bicêtre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McInnes</LastName><ForeName>Iain</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mysler</LastName><ForeName>Eduardo</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Organización Médica de Investigación, Buenos Aires, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nash</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Medicine, University of Queensland, Queensland, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pavelka</LastName><ForeName>Karel</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Institute of Rheumatology and Clinic of Rheumatology, Charles University, Prague, Czech Republic.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Poór</LastName><ForeName>Gyula</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>National Institute of Rheumatology and Physiotherapy, Semmelweis University, Budapest, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Richez</LastName><ForeName>Christophe</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Rheumatology Department, FHU ACRONIM, Pellegrin Hospital and UMR CNRS 5164, Bordeaux University, Bordeaux, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Riel</LastName><ForeName>Piet</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Bernhoven, Uden, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rubbert-Roth</LastName><ForeName>Andrea</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>University of Cologne, Cologne, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Saag</LastName><ForeName>Kenneth</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Division of Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>da Silva</LastName><ForeName>Jose</ForeName><Initials>J</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-2782-6780</Identifier><AffiliationInfo><Affiliation>Serviço de Reumatologia, Centro Hospitalar e Universitário de Coimbra Praceta Mota Pinto, Coimbra, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stamm</LastName><ForeName>Tanja</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Section for Outcomes Research, Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Takeuchi</LastName><ForeName>Tsutomu</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Keio University School of Medicine, Keio University Hospital, Tokyo, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Westhovens</LastName><ForeName>René</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Development and Regeneration, Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Belgium.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Rheumatology, University Hospitals Leuven, Leuven, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Wit</LastName><ForeName>Maarten</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department Medical Humanities, VU Medical Centre, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van der Heijde</LastName><ForeName>Désirée</ForeName><Initials>D</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-5781-158X</Identifier><AffiliationInfo><Affiliation>Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>03</Month><Day>06</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Ann Rheum Dis</MedlineTA><NlmUniqueID>0372355</NlmUniqueID><ISSNLinking>0003-4967</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000911">Antibodies, Monoclonal</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018501">Antirheumatic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005938">Glucocorticoids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D047428">Protein Kinase Inhibitors</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014409">Tumor Necrosis Factor-alpha</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.10.2</RegistryNumber><NameOfSubstance UI="D053612">Janus 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use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014409" MajorTopicYN="N">Tumor Necrosis Factor-alpha</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="Y">antagonists & inhibitors</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">DMARDs (biologic)</Keyword><Keyword MajorTopicYN="N">DMARDs (synthetic)</Keyword><Keyword MajorTopicYN="N">Disease Activity</Keyword><Keyword MajorTopicYN="N">Rheumatoid Arthritis</Keyword><Keyword MajorTopicYN="N">Treatment</Keyword></KeywordList><CoiStatement>Competing interests: A competing interests statement of all authors is attached as online supplementary material.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>10</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2017</Year><Month>01</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>02</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>3</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>8</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>3</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28264816</ArticleId><ArticleId IdType="pii">annrheumdis-2016-210715</ArticleId><ArticleId IdType="doi">10.1136/annrheumdis-2016-210715</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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