Identifying Cytomegalovirus Complications Using the Quantiferon-CMV Assay After Allogeneic Hematopoietic Stem Cell Transplantation.
Identifieur interne : 000A54 ( PubMed/Corpus ); précédent : 000A53; suivant : 000A55Identifying Cytomegalovirus Complications Using the Quantiferon-CMV Assay After Allogeneic Hematopoietic Stem Cell Transplantation.
Auteurs : Michelle K. Yong ; Paul U. Cameron ; Monica Slavin ; C Orla Morrissey ; Krystal Bergin ; Andrew Spencer ; David Ritchie ; Allen C. Cheng ; Assia Samri ; Guislaine Carcelain ; Brigitte Autran ; Sharon R. LewinSource :
- The Journal of infectious diseases [ 1537-6613 ] ; 2017.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Cytomegalovirus (immunology), Cytomegalovirus Infections (diagnosis), Cytomegalovirus Infections (immunology), Female, Hematopoietic Stem Cell Transplantation (adverse effects), Humans, Immunocompromised Host (immunology), Interferon-gamma (analysis), Interferon-gamma (metabolism), Interferon-gamma Release Tests (methods), Longitudinal Studies, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, T-Lymphocytes (immunology), Tumor Necrosis Factor-alpha (analysis), Tumor Necrosis Factor-alpha (metabolism), Young Adult.
- MESH :
- chemical , analysis : Interferon-gamma, Tumor Necrosis Factor-alpha.
- adverse effects : Hematopoietic Stem Cell Transplantation.
- diagnosis : Cytomegalovirus Infections.
- immunology : Cytomegalovirus, Cytomegalovirus Infections, Immunocompromised Host, T-Lymphocytes.
- chemical , metabolism : Interferon-gamma, Tumor Necrosis Factor-alpha.
- methods : Interferon-gamma Release Tests.
- Adolescent, Adult, Aged, Female, Humans, Longitudinal Studies, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Young Adult.
Abstract
A simple test to identify recovery of CMV-specific T-cell immunity following hematopoietic stem cell transplantation (HSCT) could assist clinicians in managing CMV-related complications.
DOI: 10.1093/infdis/jix192
PubMed: 28431019
Links to Exploration step
pubmed:28431019Le document en format XML
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Cameron</name><affiliation><nlm:affiliation>Department of Infectious Diseases, Monash University and Alfred Hospital.</nlm:affiliation></affiliation></author><author><name sortKey="Slavin, Monica" sort="Slavin, Monica" uniqKey="Slavin M" first="Monica" last="Slavin">Monica Slavin</name><affiliation><nlm:affiliation>Peter Doherty Institute for Infection and Immunity, University of Melbourne and Royal Melbourne Hospital.</nlm:affiliation></affiliation></author><author><name sortKey="Morrissey, C Orla" sort="Morrissey, C Orla" uniqKey="Morrissey C" first="C Orla" last="Morrissey">C Orla Morrissey</name><affiliation><nlm:affiliation>Department of Infectious Diseases, Monash University and Alfred Hospital.</nlm:affiliation></affiliation></author><author><name sortKey="Bergin, Krystal" sort="Bergin, Krystal" uniqKey="Bergin K" first="Krystal" last="Bergin">Krystal Bergin</name><affiliation><nlm:affiliation>Department of Haematology, Monash University and Alfred Hospital.</nlm:affiliation></affiliation></author><author><name sortKey="Spencer, Andrew" sort="Spencer, Andrew" uniqKey="Spencer A" first="Andrew" last="Spencer">Andrew Spencer</name><affiliation><nlm:affiliation>Department of Haematology, Monash University and Alfred Hospital.</nlm:affiliation></affiliation></author><author><name sortKey="Ritchie, David" sort="Ritchie, David" uniqKey="Ritchie D" first="David" last="Ritchie">David Ritchie</name><affiliation><nlm:affiliation>Department of Clinical Haematology and Bone Marrow Transplant Service, Royal Melbourne Hospital.</nlm:affiliation></affiliation></author><author><name sortKey="Cheng, Allen C" sort="Cheng, Allen C" uniqKey="Cheng A" first="Allen C" last="Cheng">Allen C. Cheng</name><affiliation><nlm:affiliation>Department of Infectious Diseases, Monash University and Alfred Hospital.</nlm:affiliation></affiliation></author><author><name sortKey="Samri, Assia" sort="Samri, Assia" uniqKey="Samri A" first="Assia" last="Samri">Assia Samri</name><affiliation><nlm:affiliation>Institut National de la Sante et de la Recherche Medicale, U1135, Centre d'Immunologie et des Maladies Infectieuses, Sorbonne Universités, University Pierre et Marie Curie.</nlm:affiliation></affiliation></author><author><name sortKey="Carcelain, Guislaine" sort="Carcelain, Guislaine" uniqKey="Carcelain G" first="Guislaine" last="Carcelain">Guislaine Carcelain</name><affiliation><nlm:affiliation>Institut National de la Sante et de la Recherche Medicale, U1135, Centre d'Immunologie et des Maladies Infectieuses, Sorbonne Universités, University Pierre et Marie Curie.</nlm:affiliation></affiliation></author><author><name sortKey="Autran, Brigitte" sort="Autran, Brigitte" uniqKey="Autran B" first="Brigitte" last="Autran">Brigitte Autran</name><affiliation><nlm:affiliation>Institut National de la Sante et de la Recherche Medicale, U1135, Centre d'Immunologie et des Maladies Infectieuses, Sorbonne Universités, University Pierre et Marie Curie.</nlm:affiliation></affiliation></author><author><name sortKey="Lewin, Sharon R" sort="Lewin, Sharon R" uniqKey="Lewin S" first="Sharon R" last="Lewin">Sharon R. Lewin</name><affiliation><nlm:affiliation>Department of Infectious Diseases, Monash University and Alfred Hospital.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28431019</idno><idno type="pmid">28431019</idno><idno type="doi">10.1093/infdis/jix192</idno><idno type="wicri:Area/PubMed/Corpus">000A54</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A54</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Identifying Cytomegalovirus Complications Using the Quantiferon-CMV Assay After Allogeneic Hematopoietic Stem Cell Transplantation.</title><author><name sortKey="Yong, Michelle K" sort="Yong, Michelle K" uniqKey="Yong M" first="Michelle K" last="Yong">Michelle K. Yong</name><affiliation><nlm:affiliation>Department of Infectious Diseases, Monash University and Alfred Hospital.</nlm:affiliation></affiliation></author><author><name sortKey="Cameron, Paul U" sort="Cameron, Paul U" uniqKey="Cameron P" first="Paul U" last="Cameron">Paul U. Cameron</name><affiliation><nlm:affiliation>Department of Infectious Diseases, Monash University and Alfred Hospital.</nlm:affiliation></affiliation></author><author><name sortKey="Slavin, Monica" sort="Slavin, Monica" uniqKey="Slavin M" first="Monica" last="Slavin">Monica Slavin</name><affiliation><nlm:affiliation>Peter Doherty Institute for Infection and Immunity, University of Melbourne and Royal Melbourne Hospital.</nlm:affiliation></affiliation></author><author><name sortKey="Morrissey, C Orla" sort="Morrissey, C Orla" uniqKey="Morrissey C" first="C Orla" last="Morrissey">C Orla Morrissey</name><affiliation><nlm:affiliation>Department of Infectious Diseases, Monash University and Alfred Hospital.</nlm:affiliation></affiliation></author><author><name sortKey="Bergin, Krystal" sort="Bergin, Krystal" uniqKey="Bergin K" first="Krystal" last="Bergin">Krystal Bergin</name><affiliation><nlm:affiliation>Department of Haematology, Monash University and Alfred Hospital.</nlm:affiliation></affiliation></author><author><name sortKey="Spencer, Andrew" sort="Spencer, Andrew" uniqKey="Spencer A" first="Andrew" last="Spencer">Andrew Spencer</name><affiliation><nlm:affiliation>Department of Haematology, Monash University and Alfred Hospital.</nlm:affiliation></affiliation></author><author><name sortKey="Ritchie, David" sort="Ritchie, David" uniqKey="Ritchie D" first="David" last="Ritchie">David Ritchie</name><affiliation><nlm:affiliation>Department of Clinical Haematology and Bone Marrow Transplant Service, Royal Melbourne Hospital.</nlm:affiliation></affiliation></author><author><name sortKey="Cheng, Allen C" sort="Cheng, Allen C" uniqKey="Cheng A" first="Allen C" last="Cheng">Allen C. Cheng</name><affiliation><nlm:affiliation>Department of Infectious Diseases, Monash University and Alfred Hospital.</nlm:affiliation></affiliation></author><author><name sortKey="Samri, Assia" sort="Samri, Assia" uniqKey="Samri A" first="Assia" last="Samri">Assia Samri</name><affiliation><nlm:affiliation>Institut National de la Sante et de la Recherche Medicale, U1135, Centre d'Immunologie et des Maladies Infectieuses, Sorbonne Universités, University Pierre et Marie Curie.</nlm:affiliation></affiliation></author><author><name sortKey="Carcelain, Guislaine" sort="Carcelain, Guislaine" uniqKey="Carcelain G" first="Guislaine" last="Carcelain">Guislaine Carcelain</name><affiliation><nlm:affiliation>Institut National de la Sante et de la Recherche Medicale, U1135, Centre d'Immunologie et des Maladies Infectieuses, Sorbonne Universités, University Pierre et Marie Curie.</nlm:affiliation></affiliation></author><author><name sortKey="Autran, Brigitte" sort="Autran, Brigitte" uniqKey="Autran B" first="Brigitte" last="Autran">Brigitte Autran</name><affiliation><nlm:affiliation>Institut National de la Sante et de la Recherche Medicale, U1135, Centre d'Immunologie et des Maladies Infectieuses, Sorbonne Universités, University Pierre et Marie Curie.</nlm:affiliation></affiliation></author><author><name sortKey="Lewin, Sharon R" sort="Lewin, Sharon R" uniqKey="Lewin S" first="Sharon R" last="Lewin">Sharon R. Lewin</name><affiliation><nlm:affiliation>Department of Infectious Diseases, Monash University and Alfred Hospital.</nlm:affiliation></affiliation></author></analytic><series><title level="j">The Journal of infectious diseases</title><idno type="eISSN">1537-6613</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Cytomegalovirus (immunology)</term><term>Cytomegalovirus Infections (diagnosis)</term><term>Cytomegalovirus Infections (immunology)</term><term>Female</term><term>Hematopoietic Stem Cell Transplantation (adverse effects)</term><term>Humans</term><term>Immunocompromised Host (immunology)</term><term>Interferon-gamma (analysis)</term><term>Interferon-gamma (metabolism)</term><term>Interferon-gamma Release Tests (methods)</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Predictive Value of Tests</term><term>Prospective Studies</term><term>T-Lymphocytes (immunology)</term><term>Tumor Necrosis Factor-alpha (analysis)</term><term>Tumor Necrosis Factor-alpha (metabolism)</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Interferon-gamma</term><term>Tumor Necrosis Factor-alpha</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Hematopoietic Stem Cell Transplantation</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Cytomegalovirus Infections</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Cytomegalovirus</term><term>Cytomegalovirus Infections</term><term>Immunocompromised Host</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Interferon-gamma</term><term>Tumor Necrosis Factor-alpha</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Interferon-gamma Release Tests</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Predictive Value of Tests</term><term>Prospective Studies</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A simple test to identify recovery of CMV-specific T-cell immunity following hematopoietic stem cell transplantation (HSCT) could assist clinicians in managing CMV-related complications.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28431019</PMID><DateCreated><Year>2017</Year><Month>04</Month><Day>21</Day></DateCreated><DateCompleted><Year>2017</Year><Month>09</Month><Day>14</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>14</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1537-6613</ISSN><JournalIssue CitedMedium="Internet"><Volume>215</Volume><Issue>11</Issue><PubDate><Year>2017</Year><Month>Jun</Month><Day>01</Day></PubDate></JournalIssue><Title>The Journal of infectious diseases</Title><ISOAbbreviation>J. Infect. Dis.</ISOAbbreviation></Journal><ArticleTitle>Identifying Cytomegalovirus Complications Using the Quantiferon-CMV Assay After Allogeneic Hematopoietic Stem Cell Transplantation.</ArticleTitle><Pagination><MedlinePgn>1684-1694</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/infdis/jix192</ELocationID><Abstract><AbstractText Label="Background" NlmCategory="UNASSIGNED">A simple test to identify recovery of CMV-specific T-cell immunity following hematopoietic stem cell transplantation (HSCT) could assist clinicians in managing CMV-related complications.</AbstractText><AbstractText Label="Methods" NlmCategory="UNASSIGNED">In an observational, multicenter, prospective study of 94 HSCT recipients we evaluated CMV-specific T-cell immunity at baseline, 3, 6, 9, and 12 months after transplant using the Quantiferon-CMV, an enzyme-linked immunosorbent spot assay (ELISpot), and intracellular cytokine staining.</AbstractText><AbstractText Label="Results" NlmCategory="UNASSIGNED">At 3 months after HSCT, participants who developed CMV disease (n = 8) compared with CMV reactivation (n = 26) or spontaneous viral control (n = 25) had significantly lower CD8+ T-cell production of interferon-γ (IFN-γ) in response to CMV antigens measured by Quantiferon-CMV (P = .0008). An indeterminate Quantiferon-CMV result had a positive predictive value of 83% and a negative predictive value of 98% for identifying participants at risk of further CMV reactivation. Participants experiencing CMV reactivation compared with patients without CMV reactivation had a reduced proportion of polyfunctional (IFN-γ+/tumor necrosis factor α-positive) CD4+ and CD8+ T cells and a higher proportion of interleukin 2-secreting cells (P = .01 and P = .002, respectively).</AbstractText><AbstractText Label="Conclusions" NlmCategory="UNASSIGNED">Quantifying CMV-specific T-cell immunity after HSCT can identify participants at increased risk of clinically relevant CMV-related outcomes.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yong</LastName><ForeName>Michelle K</ForeName><Initials>MK</Initials><AffiliationInfo><Affiliation>Department of Infectious Diseases, Monash University and Alfred Hospital.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Peter Doherty Institute for Infection and Immunity, University of Melbourne and Royal Melbourne Hospital.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cameron</LastName><ForeName>Paul U</ForeName><Initials>PU</Initials><AffiliationInfo><Affiliation>Department of Infectious Diseases, Monash University and Alfred Hospital.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Peter Doherty Institute for Infection and Immunity, University of Melbourne and Royal Melbourne Hospital.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Slavin</LastName><ForeName>Monica</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Peter Doherty Institute for Infection and Immunity, University of Melbourne and Royal Melbourne Hospital.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Victorian Infectious Diseases Service, Royal Melbourne Hospital at The Peter Doherty Institute for Infection and Immunity.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Peter MacCallum Cancer Centre.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morrissey</LastName><ForeName>C Orla</ForeName><Initials>CO</Initials><AffiliationInfo><Affiliation>Department of Infectious Diseases, Monash University and Alfred Hospital.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Haematology, Monash University and Alfred Hospital.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bergin</LastName><ForeName>Krystal</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Haematology, Monash University and Alfred Hospital.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Spencer</LastName><ForeName>Andrew</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Haematology, Monash University and Alfred Hospital.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ritchie</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Clinical Haematology and Bone Marrow Transplant Service, Royal Melbourne Hospital.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medicine, University of Melbourne, Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cheng</LastName><ForeName>Allen C</ForeName><Initials>AC</Initials><AffiliationInfo><Affiliation>Department of Infectious Diseases, Monash University and Alfred Hospital.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Samri</LastName><ForeName>Assia</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institut National de la Sante et de la Recherche Medicale, U1135, Centre d'Immunologie et des Maladies Infectieuses, Sorbonne Universités, University Pierre et Marie Curie.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Assistance Publique-Hopitaux de Paris, Hôpital Pitié-Salpêtrière, Département d'Immunologie, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carcelain</LastName><ForeName>Guislaine</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Institut National de la Sante et de la Recherche Medicale, U1135, Centre d'Immunologie et des Maladies Infectieuses, Sorbonne Universités, University Pierre et Marie Curie.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Assistance Publique-Hopitaux de Paris, Hôpital Pitié-Salpêtrière, Département d'Immunologie, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Autran</LastName><ForeName>Brigitte</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Institut National de la Sante et de la Recherche Medicale, U1135, Centre d'Immunologie et des Maladies Infectieuses, Sorbonne Universités, University Pierre et Marie Curie.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Assistance Publique-Hopitaux de Paris, Hôpital Pitié-Salpêtrière, Département d'Immunologie, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lewin</LastName><ForeName>Sharon R</ForeName><Initials>SR</Initials><AffiliationInfo><Affiliation>Department of Infectious Diseases, Monash University and Alfred Hospital.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Peter Doherty Institute for Infection and Immunity, University of Melbourne and Royal Melbourne Hospital.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Infect Dis</MedlineTA><NlmUniqueID>0413675</NlmUniqueID><ISSNLinking>0022-1899</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014409">Tumor Necrosis 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