Hypervulnerability of the adolescent prefrontal cortex to nutritional stress via reelin deficiency.
Identifieur interne : 000930 ( PubMed/Corpus ); précédent : 000929; suivant : 000931Hypervulnerability of the adolescent prefrontal cortex to nutritional stress via reelin deficiency.
Auteurs : M A Labouesse ; O. Lassalle ; J. Richetto ; J. Iafrati ; U. Weber-Stadlbauer ; T. Notter ; T. Gschwind ; L. Pujadas ; E. Soriano ; A C Reichelt ; C. Labouesse ; W. Langhans ; P. Chavis ; U. MeyerSource :
- Molecular psychiatry [ 1476-5578 ] ; 2017.
English descriptors
- KwdEn :
- Animals, Cell Adhesion Molecules, Neuronal (metabolism), Diet, High-Fat (adverse effects), Extracellular Matrix Proteins (metabolism), Male, Malnutrition (metabolism), Mice, Mice, Inbred C57BL, Mice, Transgenic, Nerve Tissue Proteins (metabolism), Neuronal Plasticity, Prefrontal Cortex (growth & development), Prefrontal Cortex (metabolism), Receptors, N-Methyl-D-Aspartate (metabolism), Serine Endopeptidases (metabolism), Synapses (metabolism).
- MESH :
- chemical , metabolism : Cell Adhesion Molecules, Neuronal, Extracellular Matrix Proteins, Nerve Tissue Proteins, Receptors, N-Methyl-D-Aspartate, Serine Endopeptidases.
- adverse effects : Diet, High-Fat.
- growth & development : Prefrontal Cortex.
- metabolism : Malnutrition, Prefrontal Cortex, Synapses.
- Animals, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Neuronal Plasticity.
Abstract
Overconsumption of high-fat diets (HFDs) can critically affect synaptic and cognitive functions within telencephalic structures such as the medial prefrontal cortex (mPFC). The underlying mechanisms, however, remain largely unknown. Here we show that adolescence is a sensitive period for the emergence of prefrontal cognitive deficits in response to HFD. We establish that the synaptic modulator reelin (RELN) is a critical mediator of this vulnerability because (1) periadolescent HFD (pHFD) selectively downregulates prefrontal RELN(+) cells and (2) augmenting mPFC RELN levels using transgenesis or prefrontal pharmacology prevents the pHFD-induced prefrontal cognitive deficits. We further identify N-methyl-d-aspartate-dependent long-term depression (NMDA-LTD) at prefrontal excitatory synapses as a synaptic signature of this association because pHFD abolishes NMDA-LTD, a function that is restored by RELN overexpression. We believe this study provides the first mechanistic insight into the vulnerability of the adolescent mPFC towards nutritional stress, such as HFDs. Our findings have primary relevance to obese individuals who are at an increased risk of developing neurological cognitive comorbidities, and may extend to multiple neuropsychiatric and neurological disorders in which RELN deficiency is a common feature.
DOI: 10.1038/mp.2016.193
PubMed: 27843148
Links to Exploration step
pubmed:27843148Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Hypervulnerability of the adolescent prefrontal cortex to nutritional stress via reelin deficiency.</title><author><name sortKey="Labouesse, M A" sort="Labouesse, M A" uniqKey="Labouesse M" first="M A" last="Labouesse">M A Labouesse</name><affiliation><nlm:affiliation>Physiology and Behavior Laboratory, ETH Zurich, Schwerzenbach, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Lassalle, O" sort="Lassalle, O" uniqKey="Lassalle O" first="O" last="Lassalle">O. Lassalle</name><affiliation><nlm:affiliation>INSERM, INMED UMR S 901, Aix-Marseille Université, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Richetto, J" sort="Richetto, J" uniqKey="Richetto J" first="J" last="Richetto">J. Richetto</name><affiliation><nlm:affiliation>Institute of Pharmacology and Toxicology, University of Zurich-Vetsuisse, Zurich, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Iafrati, J" sort="Iafrati, J" uniqKey="Iafrati J" first="J" last="Iafrati">J. Iafrati</name><affiliation><nlm:affiliation>INSERM, INMED UMR S 901, Aix-Marseille Université, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Weber Stadlbauer, U" sort="Weber Stadlbauer, U" uniqKey="Weber Stadlbauer U" first="U" last="Weber-Stadlbauer">U. Weber-Stadlbauer</name><affiliation><nlm:affiliation>Physiology and Behavior Laboratory, ETH Zurich, Schwerzenbach, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Notter, T" sort="Notter, T" uniqKey="Notter T" first="T" last="Notter">T. Notter</name><affiliation><nlm:affiliation>Institute of Pharmacology and Toxicology, University of Zurich-Vetsuisse, Zurich, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Gschwind, T" sort="Gschwind, T" uniqKey="Gschwind T" first="T" last="Gschwind">T. Gschwind</name><affiliation><nlm:affiliation>Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Pujadas, L" sort="Pujadas, L" uniqKey="Pujadas L" first="L" last="Pujadas">L. Pujadas</name><affiliation><nlm:affiliation>Department of Cell Biology, Physiology and Immunology, University of Barcelona, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Soriano, E" sort="Soriano, E" uniqKey="Soriano E" first="E" last="Soriano">E. Soriano</name><affiliation><nlm:affiliation>Department of Cell Biology, Physiology and Immunology, University of Barcelona, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Reichelt, A C" sort="Reichelt, A C" uniqKey="Reichelt A" first="A C" last="Reichelt">A C Reichelt</name><affiliation><nlm:affiliation>School of Health and Biomedical Sciences, RMIT, Melbourne, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Labouesse, C" sort="Labouesse, C" uniqKey="Labouesse C" first="C" last="Labouesse">C. Labouesse</name><affiliation><nlm:affiliation>Laboratory of Cell Biophysics, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Langhans, W" sort="Langhans, W" uniqKey="Langhans W" first="W" last="Langhans">W. Langhans</name><affiliation><nlm:affiliation>Physiology and Behavior Laboratory, ETH Zurich, Schwerzenbach, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Chavis, P" sort="Chavis, P" uniqKey="Chavis P" first="P" last="Chavis">P. Chavis</name><affiliation><nlm:affiliation>INSERM, INMED UMR S 901, Aix-Marseille Université, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Meyer, U" sort="Meyer, U" uniqKey="Meyer U" first="U" last="Meyer">U. Meyer</name><affiliation><nlm:affiliation>Physiology and Behavior Laboratory, ETH Zurich, Schwerzenbach, Switzerland.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:27843148</idno><idno type="pmid">27843148</idno><idno type="doi">10.1038/mp.2016.193</idno><idno type="wicri:Area/PubMed/Corpus">000930</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000930</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Hypervulnerability of the adolescent prefrontal cortex to nutritional stress via reelin deficiency.</title><author><name sortKey="Labouesse, M A" sort="Labouesse, M A" uniqKey="Labouesse M" first="M A" last="Labouesse">M A Labouesse</name><affiliation><nlm:affiliation>Physiology and Behavior Laboratory, ETH Zurich, Schwerzenbach, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Lassalle, O" sort="Lassalle, O" uniqKey="Lassalle O" first="O" last="Lassalle">O. Lassalle</name><affiliation><nlm:affiliation>INSERM, INMED UMR S 901, Aix-Marseille Université, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Richetto, J" sort="Richetto, J" uniqKey="Richetto J" first="J" last="Richetto">J. Richetto</name><affiliation><nlm:affiliation>Institute of Pharmacology and Toxicology, University of Zurich-Vetsuisse, Zurich, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Iafrati, J" sort="Iafrati, J" uniqKey="Iafrati J" first="J" last="Iafrati">J. Iafrati</name><affiliation><nlm:affiliation>INSERM, INMED UMR S 901, Aix-Marseille Université, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Weber Stadlbauer, U" sort="Weber Stadlbauer, U" uniqKey="Weber Stadlbauer U" first="U" last="Weber-Stadlbauer">U. Weber-Stadlbauer</name><affiliation><nlm:affiliation>Physiology and Behavior Laboratory, ETH Zurich, Schwerzenbach, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Notter, T" sort="Notter, T" uniqKey="Notter T" first="T" last="Notter">T. Notter</name><affiliation><nlm:affiliation>Institute of Pharmacology and Toxicology, University of Zurich-Vetsuisse, Zurich, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Gschwind, T" sort="Gschwind, T" uniqKey="Gschwind T" first="T" last="Gschwind">T. Gschwind</name><affiliation><nlm:affiliation>Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Pujadas, L" sort="Pujadas, L" uniqKey="Pujadas L" first="L" last="Pujadas">L. Pujadas</name><affiliation><nlm:affiliation>Department of Cell Biology, Physiology and Immunology, University of Barcelona, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Soriano, E" sort="Soriano, E" uniqKey="Soriano E" first="E" last="Soriano">E. Soriano</name><affiliation><nlm:affiliation>Department of Cell Biology, Physiology and Immunology, University of Barcelona, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Reichelt, A C" sort="Reichelt, A C" uniqKey="Reichelt A" first="A C" last="Reichelt">A C Reichelt</name><affiliation><nlm:affiliation>School of Health and Biomedical Sciences, RMIT, Melbourne, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Labouesse, C" sort="Labouesse, C" uniqKey="Labouesse C" first="C" last="Labouesse">C. Labouesse</name><affiliation><nlm:affiliation>Laboratory of Cell Biophysics, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Langhans, W" sort="Langhans, W" uniqKey="Langhans W" first="W" last="Langhans">W. Langhans</name><affiliation><nlm:affiliation>Physiology and Behavior Laboratory, ETH Zurich, Schwerzenbach, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Chavis, P" sort="Chavis, P" uniqKey="Chavis P" first="P" last="Chavis">P. Chavis</name><affiliation><nlm:affiliation>INSERM, INMED UMR S 901, Aix-Marseille Université, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Meyer, U" sort="Meyer, U" uniqKey="Meyer U" first="U" last="Meyer">U. Meyer</name><affiliation><nlm:affiliation>Physiology and Behavior Laboratory, ETH Zurich, Schwerzenbach, Switzerland.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Molecular psychiatry</title><idno type="eISSN">1476-5578</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cell Adhesion Molecules, Neuronal (metabolism)</term><term>Diet, High-Fat (adverse effects)</term><term>Extracellular Matrix Proteins (metabolism)</term><term>Male</term><term>Malnutrition (metabolism)</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mice, Transgenic</term><term>Nerve Tissue Proteins (metabolism)</term><term>Neuronal Plasticity</term><term>Prefrontal Cortex (growth & development)</term><term>Prefrontal Cortex (metabolism)</term><term>Receptors, N-Methyl-D-Aspartate (metabolism)</term><term>Serine Endopeptidases (metabolism)</term><term>Synapses (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cell Adhesion Molecules, Neuronal</term><term>Extracellular Matrix Proteins</term><term>Nerve Tissue Proteins</term><term>Receptors, N-Methyl-D-Aspartate</term><term>Serine Endopeptidases</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Diet, High-Fat</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Prefrontal Cortex</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Malnutrition</term><term>Prefrontal Cortex</term><term>Synapses</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mice, Transgenic</term><term>Neuronal Plasticity</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Overconsumption of high-fat diets (HFDs) can critically affect synaptic and cognitive functions within telencephalic structures such as the medial prefrontal cortex (mPFC). The underlying mechanisms, however, remain largely unknown. Here we show that adolescence is a sensitive period for the emergence of prefrontal cognitive deficits in response to HFD. We establish that the synaptic modulator reelin (RELN) is a critical mediator of this vulnerability because (1) periadolescent HFD (pHFD) selectively downregulates prefrontal RELN(+) cells and (2) augmenting mPFC RELN levels using transgenesis or prefrontal pharmacology prevents the pHFD-induced prefrontal cognitive deficits. We further identify N-methyl-d-aspartate-dependent long-term depression (NMDA-LTD) at prefrontal excitatory synapses as a synaptic signature of this association because pHFD abolishes NMDA-LTD, a function that is restored by RELN overexpression. We believe this study provides the first mechanistic insight into the vulnerability of the adolescent mPFC towards nutritional stress, such as HFDs. Our findings have primary relevance to obese individuals who are at an increased risk of developing neurological cognitive comorbidities, and may extend to multiple neuropsychiatric and neurological disorders in which RELN deficiency is a common feature.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27843148</PMID><DateCreated><Year>2016</Year><Month>11</Month><Day>15</Day></DateCreated><DateCompleted><Year>2017</Year><Month>11</Month><Day>02</Day></DateCompleted><DateRevised><Year>2017</Year><Month>11</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1476-5578</ISSN><JournalIssue CitedMedium="Internet"><Volume>22</Volume><Issue>7</Issue><PubDate><Year>2017</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Molecular psychiatry</Title><ISOAbbreviation>Mol. Psychiatry</ISOAbbreviation></Journal><ArticleTitle>Hypervulnerability of the adolescent prefrontal cortex to nutritional stress via reelin deficiency.</ArticleTitle><Pagination><MedlinePgn>961-971</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/mp.2016.193</ELocationID><Abstract><AbstractText>Overconsumption of high-fat diets (HFDs) can critically affect synaptic and cognitive functions within telencephalic structures such as the medial prefrontal cortex (mPFC). The underlying mechanisms, however, remain largely unknown. Here we show that adolescence is a sensitive period for the emergence of prefrontal cognitive deficits in response to HFD. We establish that the synaptic modulator reelin (RELN) is a critical mediator of this vulnerability because (1) periadolescent HFD (pHFD) selectively downregulates prefrontal RELN(+) cells and (2) augmenting mPFC RELN levels using transgenesis or prefrontal pharmacology prevents the pHFD-induced prefrontal cognitive deficits. We further identify N-methyl-d-aspartate-dependent long-term depression (NMDA-LTD) at prefrontal excitatory synapses as a synaptic signature of this association because pHFD abolishes NMDA-LTD, a function that is restored by RELN overexpression. We believe this study provides the first mechanistic insight into the vulnerability of the adolescent mPFC towards nutritional stress, such as HFDs. Our findings have primary relevance to obese individuals who are at an increased risk of developing neurological cognitive comorbidities, and may extend to multiple neuropsychiatric and neurological disorders in which RELN deficiency is a common feature.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Labouesse</LastName><ForeName>M A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Physiology and Behavior Laboratory, ETH Zurich, Schwerzenbach, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Pharmacology and Toxicology, University of Zurich-Vetsuisse, Zurich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lassalle</LastName><ForeName>O</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>INSERM, INMED UMR S 901, Aix-Marseille Université, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Richetto</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Institute of Pharmacology and Toxicology, University of Zurich-Vetsuisse, Zurich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Iafrati</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>INSERM, INMED UMR S 901, Aix-Marseille Université, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weber-Stadlbauer</LastName><ForeName>U</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Physiology and Behavior Laboratory, ETH Zurich, Schwerzenbach, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Pharmacology and Toxicology, University of Zurich-Vetsuisse, Zurich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Notter</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Institute of Pharmacology and Toxicology, University of Zurich-Vetsuisse, Zurich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gschwind</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pujadas</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Cell Biology, Physiology and Immunology, University of Barcelona, Barcelona, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centro de Investigación en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Vall [Dacute ]Hebron Institut de Recerca (VHIR), Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Soriano</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Cell Biology, Physiology and Immunology, University of Barcelona, Barcelona, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centro de Investigación en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Vall [Dacute ]Hebron Institut de Recerca (VHIR), Barcelona, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institució Catalana de Recerca i Estudis Avançats (ICREA Academia), Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reichelt</LastName><ForeName>A C</ForeName><Initials>AC</Initials><AffiliationInfo><Affiliation>School of Health and Biomedical Sciences, RMIT, Melbourne, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Labouesse</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Laboratory of Cell Biophysics, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Langhans</LastName><ForeName>W</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Physiology and Behavior Laboratory, ETH Zurich, Schwerzenbach, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chavis</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>INSERM, INMED UMR S 901, Aix-Marseille Université, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meyer</LastName><ForeName>U</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Physiology and Behavior Laboratory, ETH Zurich, Schwerzenbach, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Pharmacology and Toxicology, University of Zurich-Vetsuisse, Zurich, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Neuroscience Center Zurich (ZNZ), University of Zurich, Zurich, Switzerland.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>11</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Mol 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protein</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Development. 2012 Jan;139(1):191-202</RefSource><PMID Version="1">22115756</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Obesity (Silver Spring). 2011 Jul;19(7):1382-7</RefSource><PMID Version="1">21350433</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Scand J Public Health. 2013 Nov;41(7):754-60</RefSource><PMID Version="1">23676256</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Psychiatry Res. 2013 Dec 15;210(2):381-6</RefSource><PMID Version="1">23850204</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Clin Nutr. 1999 Sep;70(3 Suppl):560S-569S</RefSource><PMID Version="1">10479232</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Commun. 2014 Mar 06;5:3443</RefSource><PMID Version="1">24599114</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Diabetologia. 2010 Nov;53(11):2298-306</RefSource><PMID Version="1">20668831</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>JAMA. 2015 Jun 23-30;313(24):2421-2</RefSource><PMID Version="1">26103023</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2005 Sep 7;25(36):8209-16</RefSource><PMID Version="1">16148228</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurosci Biobehav Rev. 2003 Jan-Mar;27(1-2):3-18</RefSource><PMID Version="1">12732219</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurobiol Aging. 2014 Sep;35 Suppl 2:S59-64</RefSource><PMID Version="1">24970568</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurobiol Dis. 2011 Nov;44(2):239-47</RefSource><PMID Version="1">21784155</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Behav Brain Res. 2007 Aug 22;182(1):57-66</RefSource><PMID Version="1">17590450</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15731-6</RefSource><PMID Version="1">26644559</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Sci Signal. 2015 Jul 07;8(384):ra67</RefSource><PMID Version="1">26152694</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2016 Jan 27;36(4):1324-35</RefSource><PMID Version="1">26818519</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biol Psychiatry. 2013 Oct 1;74(7):490-501</RefSource><PMID Version="1">23558299</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Learn Mem. 2011 Aug 18;18(9):558-64</RefSource><PMID Version="1">21852430</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain Behav Immun. 2008 May;22(4):469-86</RefSource><PMID Version="1">18023140</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Neurosci. 2006 Nov;7(11):850-9</RefSource><PMID Version="1">17053810</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Psychiatry. 2014 Apr;19(4):417-26</RefSource><PMID Version="1">23752244</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuron. 2005 Aug 18;47(4):567-79</RefSource><PMID Version="1">16102539</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genes Brain Behav. 2015 Jan;14(1):4-21</RefSource><PMID Version="1">25561028</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 1998 Oct 1;18(19):7779-99</RefSource><PMID Version="1">9742148</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Nutr Soc. 2013 Nov;72 (4):363-71</RefSource><PMID Version="1">24028891</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuron. 2013 Jul 10;79(1):16-29</RefSource><PMID Version="1">23849196</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Sci Rep. 2016 Oct 21;6:35504</RefSource><PMID Version="1">27765946</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Front Endocrinol (Lausanne). 2014 May 15;5:74</RefSource><PMID Version="1">24860551</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Psychiatry. 2011 Jun;16(6):672-84</RefSource><PMID Version="1">21403673</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Psychoneuroendocrinology. 2013 Nov;38(11):2562-74</RefSource><PMID Version="1">23850224</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int J Obes Relat Metab Disord. 1998 Nov;22(11):1053-61</RefSource><PMID Version="1">9822942</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2010 Mar 31;30(13):4636-49</RefSource><PMID Version="1">20357114</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Child Psychol Psychiatry. 2014 Sep;55(9):1017-24</RefSource><PMID Version="1">24673485</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Pediatrics. 2006 Feb;117(2):544-59</RefSource><PMID Version="1">16452380</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Neurosci. 2005 Nov;6(11):877-88</RefSource><PMID Version="1">16261181</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell. 2016 May 5;165(4):882-95</RefSource><PMID Version="1">27133169</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Behav Neurosci. 2006 Aug;120(4):984-8</RefSource><PMID Version="1">16893304</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuroscience. 2015 Dec 3;310:528-40</RefSource><PMID Version="1">26415772</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2012 Oct 16;109 Suppl 2:17186-93</RefSource><PMID Version="1">23045653</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13473-80</RefSource><PMID Version="1">8942959</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuropharmacology. 2013 May;68:184-94</RefSource><PMID Version="1">22564440</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Psychopharmacol. 2013 Apr;27(4):386-95</RefSource><PMID Version="1">23104248</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2004 May 25;101(21):8174-9</RefSource><PMID Version="1">15148381</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain Behav Immun. 2015 Jan;43:68-75</RefSource><PMID Version="1">25043993</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Appetite. 2013 Apr;63:119-28</RefSource><PMID Version="1">23291218</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Clin Nutr. 2011 Apr;93(4):748-55</RefSource><PMID Version="1">21270386</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurobiol Learn Mem. 2006 May;85(3):228-42</RefSource><PMID Version="1">16376115</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Nutr. 2014 Aug;144(8):1291-7</RefSource><PMID Version="1">24919689</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2009;4(5):e5505</RefSource><PMID Version="1">19430527</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuropsychopharmacology. 2013 Jan;38(1):138-66</RefSource><PMID Version="1">22948975</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>FASEB J. 2011 Mar;25(3):1088-96</RefSource><PMID Version="1">21106937</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 2014 Aug 30;384(9945):766-81</RefSource><PMID Version="1">24880830</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):2060-7</RefSource><PMID Version="1">22895667</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Neurosci. 2010 Jul;11(7):459-73</RefSource><PMID Version="1">20559335</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int J Neuropsychopharmacol. 2014 Aug;17(8):1221-32</RefSource><PMID Version="1">24556017</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Acad Nutr Diet. 2016 Feb;116(2):302-10.e1</RefSource><PMID Version="1">26612769</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Neurosci. 2013 Jun;14(6):417-28</RefSource><PMID Version="1">23635870</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Neurosci. 2005 Apr;6(4):312-24</RefSource><PMID Version="1">15803162</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Learn Mem. 2015 Mar 16;22(4):215-24</RefSource><PMID Version="1">25776039</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurosci Biobehav Rev. 2000 Jun;24(4):417-63</RefSource><PMID Version="1">10817843</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuropsychopharmacology. 2006 Oct;31(10 ):2091-120</RefSource><PMID Version="1">16541087</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2006 Dec 13;26(50):12943-55</RefSource><PMID Version="1">17167084</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuroscience. 2015 Nov 19;309:125-39</RefSource><PMID Version="1">25934036</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Br J Pharmacol. 2011 Oct;164(4):1248-62</RefSource><PMID Version="1">21265828</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuroscience. 2013 Aug 29;246:108-16</RefSource><PMID Version="1">23632168</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuropsychopharmacology. 2011 Nov;36(12):2395-405</RefSource><PMID Version="1">21814183</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Psychopharmacology (Berl). 2006 Nov;189(1):95-104</RefSource><PMID Version="1">16977475</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Gen Psychiatry. 2000 Jan;57(1):65-73</RefSource><PMID Version="1">10632234</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Behav Brain Res. 2015 Jan 1;276:130-42</RefSource><PMID Version="1">24747658</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2007 Sep 19;27(38):10165-75</RefSource><PMID Version="1">17881522</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuroimage Clin. 2016 Jul 12;12:262-8</RefSource><PMID Version="1">27504261</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurophysiol. 2009 May;101(5):2516-27</RefSource><PMID Version="1">19244354</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biol Psychiatry. 2013 Mar 15;73(6):574-82</RefSource><PMID Version="1">23140664</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuropsychopharmacology. 2011 Nov;36(12):2371-2</RefSource><PMID Version="1">21997708</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hippocampus. 2012 Nov;22(11):2095-100</RefSource><PMID Version="1">22593080</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015816" MajorTopicYN="N">Cell Adhesion Molecules, Neuronal</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D059305" MajorTopicYN="N">Diet, High-Fat</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016326" MajorTopicYN="N">Extracellular Matrix Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D044342" 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