Role of iron in the pathogenesis of respiratory disease.
Identifieur interne : 000906 ( PubMed/Corpus ); précédent : 000905; suivant : 000907Role of iron in the pathogenesis of respiratory disease.
Auteurs : Md Khadem Ali ; Richard Y. Kim ; Rafia Karim ; Jemma R. Mayall ; Kristy L. Martin ; Ali Shahandeh ; Firouz Abbasian ; Malcolm R. Starkey ; Veronique Loustaud-Ratti ; Daniel Johnstone ; Elizabeth A. Milward ; Philip M. Hansbro ; Jay C. HorvatSource :
- The international journal of biochemistry & cell biology [ 1878-5875 ] ; 2017.
Abstract
Iron is essential for many biological processes, however, too much or too little iron can result in a wide variety of pathological consequences, depending on the organ system, tissue or cell type affected. In order to reduce pathogenesis, iron levels are tightly controlled in throughout the body by regulatory systems that control iron absorption, systemic transport and cellular uptake and storage. Altered iron levels and/or dysregulated homeostasis have been associated with several lung diseases, including chronic obstructive pulmonary disease, lung cancer, cystic fibrosis, idiopathic pulmonary fibrosis and asthma. However, the mechanisms that underpin these associations and whether iron plays a key role in the pathogenesis of lung disease are yet to be fully elucidated. Furthermore, in order to survive and replicate, pathogenic micro-organisms have evolved strategies to source host iron, including freeing iron from cells and proteins that store and transport iron. To counter these microbial strategies, mammals have evolved immune-mediated defence mechanisms that reduce iron availability to pathogens. This interplay between iron, infection and immunity has important ramifications for the pathogenesis and management of human respiratory infections and diseases. An increased understanding of the role that iron plays in the pathogenesis of lung disease and respiratory infections may help inform novel therapeutic strategies. Here we review the clinical and experimental evidence that highlights the potential importance of iron in respiratory diseases and infections.
DOI: 10.1016/j.biocel.2017.05.003
PubMed: 28495571
Links to Exploration step
pubmed:28495571Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Role of iron in the pathogenesis of respiratory disease.</title><author><name sortKey="Ali, Md Khadem" sort="Ali, Md Khadem" uniqKey="Ali M" first="Md Khadem" last="Ali">Md Khadem Ali</name><affiliation><nlm:affiliation>School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, Callaghan NSW 2308, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Richard Y" sort="Kim, Richard Y" uniqKey="Kim R" first="Richard Y" last="Kim">Richard Y. Kim</name><affiliation><nlm:affiliation>School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, Callaghan NSW 2308, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Karim, Rafia" sort="Karim, Rafia" uniqKey="Karim R" first="Rafia" last="Karim">Rafia Karim</name><affiliation><nlm:affiliation>School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, Callaghan NSW 2308, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Mayall, Jemma R" sort="Mayall, Jemma R" uniqKey="Mayall J" first="Jemma R" last="Mayall">Jemma R. Mayall</name><affiliation><nlm:affiliation>School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, Callaghan NSW 2308, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Martin, Kristy L" sort="Martin, Kristy L" uniqKey="Martin K" first="Kristy L" last="Martin">Kristy L. Martin</name><affiliation><nlm:affiliation>School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, Callaghan NSW 2308, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Shahandeh, Ali" sort="Shahandeh, Ali" uniqKey="Shahandeh A" first="Ali" last="Shahandeh">Ali Shahandeh</name><affiliation><nlm:affiliation>School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, Callaghan NSW 2308, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Abbasian, Firouz" sort="Abbasian, Firouz" uniqKey="Abbasian F" first="Firouz" last="Abbasian">Firouz Abbasian</name><affiliation><nlm:affiliation>Global Centre for Environmental Remediation, Faculty of Science, the University of Newcastle, Callaghan, NSW 2308, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Starkey, Malcolm R" sort="Starkey, Malcolm R" uniqKey="Starkey M" first="Malcolm R" last="Starkey">Malcolm R. Starkey</name><affiliation><nlm:affiliation>School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, Callaghan NSW 2308, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Loustaud Ratti, Veronique" sort="Loustaud Ratti, Veronique" uniqKey="Loustaud Ratti V" first="Veronique" last="Loustaud-Ratti">Veronique Loustaud-Ratti</name><affiliation><nlm:affiliation>U850 INSERM, University of Limoges, CHU Limoges, F-87000 Limoges, France.</nlm:affiliation></affiliation></author><author><name sortKey="Johnstone, Daniel" sort="Johnstone, Daniel" uniqKey="Johnstone D" first="Daniel" last="Johnstone">Daniel Johnstone</name><affiliation><nlm:affiliation>Bosch Institute and Discipline of Physiology, The University of Sydney, Sydney NSW 2000, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Milward, Elizabeth A" sort="Milward, Elizabeth A" uniqKey="Milward E" first="Elizabeth A" last="Milward">Elizabeth A. Milward</name><affiliation><nlm:affiliation>School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, Callaghan NSW 2308, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Hansbro, Philip M" sort="Hansbro, Philip M" uniqKey="Hansbro P" first="Philip M" last="Hansbro">Philip M. Hansbro</name><affiliation><nlm:affiliation>School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, Callaghan NSW 2308, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Horvat, Jay C" sort="Horvat, Jay C" uniqKey="Horvat J" first="Jay C" last="Horvat">Jay C. Horvat</name><affiliation><nlm:affiliation>School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, Callaghan NSW 2308, Australia. Electronic address: jay.horvat@newcastle.edu.au.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28495571</idno><idno type="pmid">28495571</idno><idno type="doi">10.1016/j.biocel.2017.05.003</idno><idno type="wicri:Area/PubMed/Corpus">000906</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000906</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Role of iron in the pathogenesis of respiratory disease.</title><author><name sortKey="Ali, Md Khadem" sort="Ali, Md Khadem" uniqKey="Ali M" first="Md Khadem" last="Ali">Md Khadem Ali</name><affiliation><nlm:affiliation>School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, Callaghan NSW 2308, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Richard Y" sort="Kim, Richard Y" uniqKey="Kim R" first="Richard Y" last="Kim">Richard Y. Kim</name><affiliation><nlm:affiliation>School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, Callaghan NSW 2308, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Karim, Rafia" sort="Karim, Rafia" uniqKey="Karim R" first="Rafia" last="Karim">Rafia Karim</name><affiliation><nlm:affiliation>School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, Callaghan NSW 2308, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Mayall, Jemma R" sort="Mayall, Jemma R" uniqKey="Mayall J" first="Jemma R" last="Mayall">Jemma R. Mayall</name><affiliation><nlm:affiliation>School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, Callaghan NSW 2308, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Martin, Kristy L" sort="Martin, Kristy L" uniqKey="Martin K" first="Kristy L" last="Martin">Kristy L. Martin</name><affiliation><nlm:affiliation>School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, Callaghan NSW 2308, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Shahandeh, Ali" sort="Shahandeh, Ali" uniqKey="Shahandeh A" first="Ali" last="Shahandeh">Ali Shahandeh</name><affiliation><nlm:affiliation>School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, Callaghan NSW 2308, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Abbasian, Firouz" sort="Abbasian, Firouz" uniqKey="Abbasian F" first="Firouz" last="Abbasian">Firouz Abbasian</name><affiliation><nlm:affiliation>Global Centre for Environmental Remediation, Faculty of Science, the University of Newcastle, Callaghan, NSW 2308, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Starkey, Malcolm R" sort="Starkey, Malcolm R" uniqKey="Starkey M" first="Malcolm R" last="Starkey">Malcolm R. Starkey</name><affiliation><nlm:affiliation>School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, Callaghan NSW 2308, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Loustaud Ratti, Veronique" sort="Loustaud Ratti, Veronique" uniqKey="Loustaud Ratti V" first="Veronique" last="Loustaud-Ratti">Veronique Loustaud-Ratti</name><affiliation><nlm:affiliation>U850 INSERM, University of Limoges, CHU Limoges, F-87000 Limoges, France.</nlm:affiliation></affiliation></author><author><name sortKey="Johnstone, Daniel" sort="Johnstone, Daniel" uniqKey="Johnstone D" first="Daniel" last="Johnstone">Daniel Johnstone</name><affiliation><nlm:affiliation>Bosch Institute and Discipline of Physiology, The University of Sydney, Sydney NSW 2000, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Milward, Elizabeth A" sort="Milward, Elizabeth A" uniqKey="Milward E" first="Elizabeth A" last="Milward">Elizabeth A. Milward</name><affiliation><nlm:affiliation>School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, Callaghan NSW 2308, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Hansbro, Philip M" sort="Hansbro, Philip M" uniqKey="Hansbro P" first="Philip M" last="Hansbro">Philip M. Hansbro</name><affiliation><nlm:affiliation>School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, Callaghan NSW 2308, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Horvat, Jay C" sort="Horvat, Jay C" uniqKey="Horvat J" first="Jay C" last="Horvat">Jay C. Horvat</name><affiliation><nlm:affiliation>School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, Callaghan NSW 2308, Australia. Electronic address: jay.horvat@newcastle.edu.au.</nlm:affiliation></affiliation></author></analytic><series><title level="j">The international journal of biochemistry & cell biology</title><idno type="eISSN">1878-5875</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Iron is essential for many biological processes, however, too much or too little iron can result in a wide variety of pathological consequences, depending on the organ system, tissue or cell type affected. In order to reduce pathogenesis, iron levels are tightly controlled in throughout the body by regulatory systems that control iron absorption, systemic transport and cellular uptake and storage. Altered iron levels and/or dysregulated homeostasis have been associated with several lung diseases, including chronic obstructive pulmonary disease, lung cancer, cystic fibrosis, idiopathic pulmonary fibrosis and asthma. However, the mechanisms that underpin these associations and whether iron plays a key role in the pathogenesis of lung disease are yet to be fully elucidated. Furthermore, in order to survive and replicate, pathogenic micro-organisms have evolved strategies to source host iron, including freeing iron from cells and proteins that store and transport iron. To counter these microbial strategies, mammals have evolved immune-mediated defence mechanisms that reduce iron availability to pathogens. This interplay between iron, infection and immunity has important ramifications for the pathogenesis and management of human respiratory infections and diseases. An increased understanding of the role that iron plays in the pathogenesis of lung disease and respiratory infections may help inform novel therapeutic strategies. Here we review the clinical and experimental evidence that highlights the potential importance of iron in respiratory diseases and infections.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28495571</PMID><DateCreated><Year>2017</Year><Month>05</Month><Day>12</Day></DateCreated><DateRevised><Year>2017</Year><Month>07</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1878-5875</ISSN><JournalIssue CitedMedium="Internet"><Volume>88</Volume><PubDate><Year>2017</Year><Month>Jul</Month></PubDate></JournalIssue><Title>The international journal of biochemistry & cell biology</Title><ISOAbbreviation>Int. J. Biochem. Cell Biol.</ISOAbbreviation></Journal><ArticleTitle>Role of iron in the pathogenesis of respiratory disease.</ArticleTitle><Pagination><MedlinePgn>181-195</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1357-2725(17)30093-6</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.biocel.2017.05.003</ELocationID><Abstract><AbstractText>Iron is essential for many biological processes, however, too much or too little iron can result in a wide variety of pathological consequences, depending on the organ system, tissue or cell type affected. In order to reduce pathogenesis, iron levels are tightly controlled in throughout the body by regulatory systems that control iron absorption, systemic transport and cellular uptake and storage. Altered iron levels and/or dysregulated homeostasis have been associated with several lung diseases, including chronic obstructive pulmonary disease, lung cancer, cystic fibrosis, idiopathic pulmonary fibrosis and asthma. However, the mechanisms that underpin these associations and whether iron plays a key role in the pathogenesis of lung disease are yet to be fully elucidated. Furthermore, in order to survive and replicate, pathogenic micro-organisms have evolved strategies to source host iron, including freeing iron from cells and proteins that store and transport iron. To counter these microbial strategies, mammals have evolved immune-mediated defence mechanisms that reduce iron availability to pathogens. This interplay between iron, infection and immunity has important ramifications for the pathogenesis and management of human respiratory infections and diseases. An increased understanding of the role that iron plays in the pathogenesis of lung disease and respiratory infections may help inform novel therapeutic strategies. Here we review the clinical and experimental evidence that highlights the potential importance of iron in respiratory diseases and infections.</AbstractText><CopyrightInformation>Copyright © 2017 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ali</LastName><ForeName>Md Khadem</ForeName><Initials>MK</Initials><AffiliationInfo><Affiliation>School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, Callaghan NSW 2308, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Richard Y</ForeName><Initials>RY</Initials><AffiliationInfo><Affiliation>School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, Callaghan NSW 2308, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Karim</LastName><ForeName>Rafia</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, Callaghan NSW 2308, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mayall</LastName><ForeName>Jemma R</ForeName><Initials>JR</Initials><AffiliationInfo><Affiliation>School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, Callaghan NSW 2308, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martin</LastName><ForeName>Kristy L</ForeName><Initials>KL</Initials><AffiliationInfo><Affiliation>School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, Callaghan NSW 2308, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shahandeh</LastName><ForeName>Ali</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, Callaghan NSW 2308, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abbasian</LastName><ForeName>Firouz</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Global Centre for Environmental Remediation, Faculty of Science, the University of Newcastle, Callaghan, NSW 2308, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Starkey</LastName><ForeName>Malcolm R</ForeName><Initials>MR</Initials><AffiliationInfo><Affiliation>School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, Callaghan NSW 2308, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Loustaud-Ratti</LastName><ForeName>Veronique</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>U850 INSERM, University of Limoges, CHU Limoges, F-87000 Limoges, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Johnstone</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Bosch Institute and Discipline of Physiology, The University of Sydney, Sydney NSW 2000, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Milward</LastName><ForeName>Elizabeth A</ForeName><Initials>EA</Initials><AffiliationInfo><Affiliation>School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, Callaghan NSW 2308, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hansbro</LastName><ForeName>Philip M</ForeName><Initials>PM</Initials><AffiliationInfo><Affiliation>School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, Callaghan NSW 2308, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Horvat</LastName><ForeName>Jay C</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, Callaghan NSW 2308, Australia. Electronic address: jay.horvat@newcastle.edu.au.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>05</Month><Day>07</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Int J Biochem Cell Biol</MedlineTA><NlmUniqueID>9508482</NlmUniqueID><ISSNLinking>1357-2725</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Host–pathogen interaction</Keyword><Keyword MajorTopicYN="N">Immunity</Keyword><Keyword MajorTopicYN="N">Infection</Keyword><Keyword MajorTopicYN="N">Iron</Keyword><Keyword MajorTopicYN="N">Lung disease</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>12</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2017</Year><Month>05</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>05</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>5</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>5</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>5</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28495571</ArticleId><ArticleId IdType="pii">S1357-2725(17)30093-6</ArticleId><ArticleId IdType="doi">10.1016/j.biocel.2017.05.003</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000906 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000906 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:28495571
|texte= Role of iron in the pathogenesis of respiratory disease.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:28495571" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |