Increasing use of allogeneic hematopoietic cell transplantation in patients aged 70 years and older in the United States.
Identifieur interne : 000819 ( PubMed/Corpus ); précédent : 000818; suivant : 000820Increasing use of allogeneic hematopoietic cell transplantation in patients aged 70 years and older in the United States.
Auteurs : Lori Muffly ; Marcelo C. Pasquini ; Michael Martens ; Ruta Brazauskas ; Xiaochun Zhu ; Kehinde Adekola ; Mahmoud Aljurf ; Karen K. Ballen ; Ashish Bajel ; Frederic Baron ; Minoo Battiwalla ; Amer Beitinjaneh ; Jean-Yves Cahn ; Mathew Carabasi ; Yi-Bin Chen ; Saurabh Chhabra ; Stefan Ciurea ; Edward Copelan ; Anita D'Souza ; John Edwards ; James Foran ; Cesar O. Freytes ; Henry C. Fung ; Robert Peter Gale ; Sergio Giralt ; Shahrukh K. Hashmi ; Gerhard C. Hildebrandt ; Vincent Ho ; Ann Jakubowski ; Hillard Lazarus ; Marlise R. Luskin ; Rodrigo Martino ; Richard Maziarz ; Philip Mccarthy ; Taiga Nishihori ; Rebecca Olin ; Richard F. Olsson ; Attaphol Pawarode ; Edward Peres ; Andrew R. Rezvani ; David Rizzieri ; Bipin N. Savani ; Harry C. Schouten ; Mitchell Sabloff ; Matthew Seftel ; Sachiko Seo ; Mohamed L. Sorror ; Jeff Szer ; Baldeep M. Wirk ; William A. Wood ; Andrew ArtzSource :
- Blood [ 1528-0020 ] ; 2017.
English descriptors
- KwdEn :
- MESH :
Abstract
In this study, we evaluated trends and outcomes of allogeneic hematopoietic cell transplantation (HCT) in adults ≥70 years with hematologic malignancies across the United States. Adults ≥70 years with a hematologic malignancy undergoing first allogeneic HCT in the United States between 2000 and 2013 and reported to the Center for International Blood and Marrow Transplant Research were eligible. Transplant utilization and transplant outcomes, including overall survival (OS), progression-free survival (PFS), and transplant-related mortality (TRM) were studied. One thousand one hundred and six patients ≥70 years underwent HCT across 103 transplant centers. The number and proportion of allografts performed in this population rose markedly over the past decade, accounting for 0.1% of transplants in 2000 to 3.85% (N = 298) in 2013. Acute myeloid leukemia and myelodysplastic syndromes represented the most common disease indications. Two-year OS and PFS significantly improved over time (OS: 26% [95% confidence interval (CI), 21% to 33%] in 2000-2007 to 39% [95% CI, 35% to 42%] in 2008-2013, P < .001; PFS: 22% [16% to 28%] in 2000-2007 to 32% [95% CI, 29% to 36%] in 2008-2013, P = .003). Two-year TRM ranged from 33% to 35% and was unchanged over time (P = .54). Multivariable analysis of OS in the modern era of 2008-2013 revealed higher comorbidity by HCT comorbidity index ≥3 (hazard ratio [HR], 1.27; P = .006), umbilical cord blood graft (HR, 1.97; P = .0002), and myeloablative conditioning (HR, 1.61; P = .0002) as adverse factors. Over the past decade, utilization and survival after allogeneic transplant have increased in patients ≥70 years. Select adults ≥70 years with hematologic malignancies should be considered for transplant.
DOI: 10.1182/blood-2017-03-772368
PubMed: 28674027
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pubmed:28674027Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Increasing use of allogeneic hematopoietic cell transplantation in patients aged 70 years and older in the United States.</title><author><name sortKey="Muffly, Lori" sort="Muffly, Lori" uniqKey="Muffly L" first="Lori" last="Muffly">Lori Muffly</name><affiliation><nlm:affiliation>Division of Blood and Marrow Transplantation, Stanford University, Stanford, CA.</nlm:affiliation></affiliation></author><author><name sortKey="Pasquini, Marcelo C" sort="Pasquini, Marcelo C" uniqKey="Pasquini M" first="Marcelo C" last="Pasquini">Marcelo C. Pasquini</name><affiliation><nlm:affiliation>Center for International Blood and Marrow Transplant Research and.</nlm:affiliation></affiliation></author><author><name sortKey="Martens, Michael" sort="Martens, Michael" uniqKey="Martens M" first="Michael" last="Martens">Michael Martens</name><affiliation><nlm:affiliation>Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI.</nlm:affiliation></affiliation></author><author><name sortKey="Brazauskas, Ruta" sort="Brazauskas, Ruta" uniqKey="Brazauskas R" first="Ruta" last="Brazauskas">Ruta Brazauskas</name><affiliation><nlm:affiliation>Center for International Blood and Marrow Transplant Research and.</nlm:affiliation></affiliation></author><author><name sortKey="Zhu, Xiaochun" sort="Zhu, Xiaochun" uniqKey="Zhu X" first="Xiaochun" last="Zhu">Xiaochun Zhu</name><affiliation><nlm:affiliation>Center for International Blood and Marrow Transplant Research and.</nlm:affiliation></affiliation></author><author><name sortKey="Adekola, Kehinde" sort="Adekola, Kehinde" uniqKey="Adekola K" first="Kehinde" last="Adekola">Kehinde Adekola</name><affiliation><nlm:affiliation>Northwestern Memorial Hospital, Chicago, IL.</nlm:affiliation></affiliation></author><author><name sortKey="Aljurf, Mahmoud" sort="Aljurf, Mahmoud" uniqKey="Aljurf M" first="Mahmoud" last="Aljurf">Mahmoud Aljurf</name><affiliation><nlm:affiliation>Department of Oncology, King Faisal Specialist Hospital Center and Research, Riyadh, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Ballen, Karen K" sort="Ballen, Karen K" uniqKey="Ballen K" first="Karen K" last="Ballen">Karen K. Ballen</name><affiliation><nlm:affiliation>Department of Hematology/Oncology, Massachusetts General Hospital, Boston, MA.</nlm:affiliation></affiliation></author><author><name sortKey="Bajel, Ashish" sort="Bajel, Ashish" uniqKey="Bajel A" first="Ashish" last="Bajel">Ashish Bajel</name><affiliation><nlm:affiliation>Royal Melbourne Hospital, Victoria, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Baron, Frederic" sort="Baron, Frederic" uniqKey="Baron F" first="Frederic" last="Baron">Frederic Baron</name><affiliation><nlm:affiliation>Centre Hospitalier Universitaire de Liege, Domaine Universitaire du Sart Tilman, Liege, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Battiwalla, Minoo" sort="Battiwalla, Minoo" uniqKey="Battiwalla M" first="Minoo" last="Battiwalla">Minoo Battiwalla</name><affiliation><nlm:affiliation>Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD.</nlm:affiliation></affiliation></author><author><name sortKey="Beitinjaneh, Amer" sort="Beitinjaneh, Amer" uniqKey="Beitinjaneh A" first="Amer" last="Beitinjaneh">Amer Beitinjaneh</name><affiliation><nlm:affiliation>Department of Hematology and Oncology, University of Miami, Miami, FL.</nlm:affiliation></affiliation></author><author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name><affiliation><nlm:affiliation>Department of Hematology, University Hospital, Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Carabasi, Mathew" sort="Carabasi, Mathew" uniqKey="Carabasi M" first="Mathew" last="Carabasi">Mathew Carabasi</name><affiliation><nlm:affiliation>Department of Medical Oncology, Thomas Jefferson University Hospital, Philadelphia, PA.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Yi Bin" sort="Chen, Yi Bin" uniqKey="Chen Y" first="Yi-Bin" last="Chen">Yi-Bin Chen</name><affiliation><nlm:affiliation>Division of Hematology/Oncology, Massachusetts General Hospital, Boston, MA.</nlm:affiliation></affiliation></author><author><name sortKey="Chhabra, Saurabh" sort="Chhabra, Saurabh" uniqKey="Chhabra S" first="Saurabh" last="Chhabra">Saurabh Chhabra</name><affiliation><nlm:affiliation>Department of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI.</nlm:affiliation></affiliation></author><author><name sortKey="Ciurea, Stefan" sort="Ciurea, Stefan" uniqKey="Ciurea S" first="Stefan" last="Ciurea">Stefan Ciurea</name><affiliation><nlm:affiliation>Department of Stem Cell Transplantation and Cellular Therapy and.</nlm:affiliation></affiliation></author><author><name sortKey="Copelan, Edward" sort="Copelan, Edward" uniqKey="Copelan E" first="Edward" last="Copelan">Edward Copelan</name><affiliation><nlm:affiliation>Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC.</nlm:affiliation></affiliation></author><author><name sortKey="D Souza, Anita" sort="D Souza, Anita" uniqKey="D Souza A" first="Anita" last="D'Souza">Anita D'Souza</name><affiliation><nlm:affiliation>Center for International Blood and Marrow Transplant Research and.</nlm:affiliation></affiliation></author><author><name sortKey="Edwards, John" sort="Edwards, John" uniqKey="Edwards J" first="John" last="Edwards">John Edwards</name><affiliation><nlm:affiliation>Indiana Blood and Marrow Transplantation, Indianapolis, IN.</nlm:affiliation></affiliation></author><author><name sortKey="Foran, James" sort="Foran, James" uniqKey="Foran J" first="James" last="Foran">James Foran</name><affiliation><nlm:affiliation>Mayo Clinic, Jacksonville, FL.</nlm:affiliation></affiliation></author><author><name sortKey="Freytes, Cesar O" sort="Freytes, Cesar O" uniqKey="Freytes C" first="Cesar O" last="Freytes">Cesar O. Freytes</name><affiliation><nlm:affiliation>Texas Transplant Institute, San Antonio, TX.</nlm:affiliation></affiliation></author><author><name sortKey="Fung, Henry C" sort="Fung, Henry C" uniqKey="Fung H" first="Henry C" last="Fung">Henry C. Fung</name><affiliation><nlm:affiliation>Department of Medical Oncology, Fox Chase Cancer Center, Temple Health, Philadelphia, PA.</nlm:affiliation></affiliation></author><author><name sortKey="Gale, Robert Peter" sort="Gale, Robert Peter" uniqKey="Gale R" first="Robert Peter" last="Gale">Robert Peter Gale</name><affiliation><nlm:affiliation>Hematology Research Centre, Division of Experimental Medicine, Department of Medicine, Imperial College London, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Giralt, Sergio" sort="Giralt, Sergio" uniqKey="Giralt S" first="Sergio" last="Giralt">Sergio Giralt</name><affiliation><nlm:affiliation>Memorial Sloan Kettering Cancer Center, New York, NY.</nlm:affiliation></affiliation></author><author><name sortKey="Hashmi, Shahrukh K" sort="Hashmi, Shahrukh K" uniqKey="Hashmi S" first="Shahrukh K" last="Hashmi">Shahrukh K. Hashmi</name><affiliation><nlm:affiliation>Department of Internal Medicine, Mayo Clinic, Minneapolis, MN.</nlm:affiliation></affiliation></author><author><name sortKey="Hildebrandt, Gerhard C" sort="Hildebrandt, Gerhard C" uniqKey="Hildebrandt G" first="Gerhard C" last="Hildebrandt">Gerhard C. Hildebrandt</name><affiliation><nlm:affiliation>Department of Internal Medicine, University of Kentucky Chandler Medical Center, Lexington, KY.</nlm:affiliation></affiliation></author><author><name sortKey="Ho, Vincent" sort="Ho, Vincent" uniqKey="Ho V" first="Vincent" last="Ho">Vincent Ho</name><affiliation><nlm:affiliation>Center for Hematologic Oncology, Dana-Farber Cancer Institute, Boston, MA.</nlm:affiliation></affiliation></author><author><name sortKey="Jakubowski, Ann" sort="Jakubowski, Ann" uniqKey="Jakubowski A" first="Ann" last="Jakubowski">Ann Jakubowski</name><affiliation><nlm:affiliation>Memorial Sloan Kettering Cancer Center, New York, NY.</nlm:affiliation></affiliation></author><author><name sortKey="Lazarus, Hillard" sort="Lazarus, Hillard" uniqKey="Lazarus H" first="Hillard" last="Lazarus">Hillard Lazarus</name><affiliation><nlm:affiliation>Seidman Cancer Center, University Hospitals Cleveland Medical Center, Cleveland, OH.</nlm:affiliation></affiliation></author><author><name sortKey="Luskin, Marlise R" sort="Luskin, Marlise R" uniqKey="Luskin M" first="Marlise R" last="Luskin">Marlise R. Luskin</name><affiliation><nlm:affiliation>Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA.</nlm:affiliation></affiliation></author><author><name sortKey="Martino, Rodrigo" sort="Martino, Rodrigo" uniqKey="Martino R" first="Rodrigo" last="Martino">Rodrigo Martino</name><affiliation><nlm:affiliation>Divison of Clinical Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Maziarz, Richard" sort="Maziarz, Richard" uniqKey="Maziarz R" first="Richard" last="Maziarz">Richard Maziarz</name><affiliation><nlm:affiliation>Adult Blood and Marrow Stem Cell Transplant Program, Knight Cancer Institute, Oregon Health and Science University, Portland, OR.</nlm:affiliation></affiliation></author><author><name sortKey="Mccarthy, Philip" sort="Mccarthy, Philip" uniqKey="Mccarthy P" first="Philip" last="Mccarthy">Philip Mccarthy</name><affiliation><nlm:affiliation>Blood and Marrow Transplant Program, Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY.</nlm:affiliation></affiliation></author><author><name sortKey="Nishihori, Taiga" sort="Nishihori, Taiga" uniqKey="Nishihori T" first="Taiga" last="Nishihori">Taiga Nishihori</name><affiliation><nlm:affiliation>Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.</nlm:affiliation></affiliation></author><author><name sortKey="Olin, Rebecca" sort="Olin, Rebecca" uniqKey="Olin R" first="Rebecca" last="Olin">Rebecca Olin</name><affiliation><nlm:affiliation>Department of Medicine, University of California San Francisco Medical Center, San Francisco, CA.</nlm:affiliation></affiliation></author><author><name sortKey="Olsson, Richard F" sort="Olsson, Richard F" uniqKey="Olsson R" first="Richard F" last="Olsson">Richard F. Olsson</name><affiliation><nlm:affiliation>Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Pawarode, Attaphol" sort="Pawarode, Attaphol" uniqKey="Pawarode A" first="Attaphol" last="Pawarode">Attaphol Pawarode</name><affiliation><nlm:affiliation>Blood and Marrow Transplantation Program, Division of Hematology/Oncology, Department of Internal Medicine, The University of Michigan Medical School, Ann Arbor, MI.</nlm:affiliation></affiliation></author><author><name sortKey="Peres, Edward" sort="Peres, Edward" uniqKey="Peres E" first="Edward" last="Peres">Edward Peres</name><affiliation><nlm:affiliation>Bone Marrow Transplant Program, Henry Ford Hospital, Detroit, MI.</nlm:affiliation></affiliation></author><author><name sortKey="Rezvani, Andrew R" sort="Rezvani, Andrew R" uniqKey="Rezvani A" first="Andrew R" last="Rezvani">Andrew R. Rezvani</name><affiliation><nlm:affiliation>Division of Blood and Marrow Transplantation, Stanford University, Stanford, CA.</nlm:affiliation></affiliation></author><author><name sortKey="Rizzieri, David" sort="Rizzieri, David" uniqKey="Rizzieri D" first="David" last="Rizzieri">David Rizzieri</name><affiliation><nlm:affiliation>Division of Hematologic Malignancies and Cellular Therapy, Blood and Marrow Transplant Clinic, Duke University, Durham, NC.</nlm:affiliation></affiliation></author><author><name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N" last="Savani">Bipin N. Savani</name><affiliation><nlm:affiliation>Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.</nlm:affiliation></affiliation></author><author><name sortKey="Schouten, Harry C" sort="Schouten, Harry C" uniqKey="Schouten H" first="Harry C" last="Schouten">Harry C. Schouten</name><affiliation><nlm:affiliation>Department of Hematology, Academische Ziekenhuis, Maastricht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Sabloff, Mitchell" sort="Sabloff, Mitchell" uniqKey="Sabloff M" first="Mitchell" last="Sabloff">Mitchell Sabloff</name><affiliation><nlm:affiliation>Division of Hematology, Department of Medicine, University of Ottawa and Ottawa Hospital Research Institute, Ottawa, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Seftel, Matthew" sort="Seftel, Matthew" uniqKey="Seftel M" first="Matthew" last="Seftel">Matthew Seftel</name><affiliation><nlm:affiliation>Department of Medical Oncology and Hematology, CancerCare Manitoba, Winnipeg, MB, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Seo, Sachiko" sort="Seo, Sachiko" uniqKey="Seo S" first="Sachiko" last="Seo">Sachiko Seo</name><affiliation><nlm:affiliation>National Cancer Research Center, East Hospital, Kashiwa, Chiba, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Sorror, Mohamed L" sort="Sorror, Mohamed L" uniqKey="Sorror M" first="Mohamed L" last="Sorror">Mohamed L. Sorror</name><affiliation><nlm:affiliation>Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA.</nlm:affiliation></affiliation></author><author><name sortKey="Szer, Jeff" sort="Szer, Jeff" uniqKey="Szer J" first="Jeff" last="Szer">Jeff Szer</name><affiliation><nlm:affiliation>Department Clinical Haematology and Bone Marrow Transplantation, Royal Melbourne Hospital, Victoria, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Wirk, Baldeep M" sort="Wirk, Baldeep M" uniqKey="Wirk B" first="Baldeep M" last="Wirk">Baldeep M. Wirk</name><affiliation><nlm:affiliation>Division of Bone Marrow Transplant, Seattle Cancer Care Alliance, Seattle, WA.</nlm:affiliation></affiliation></author><author><name sortKey="Wood, William A" sort="Wood, William A" uniqKey="Wood W" first="William A" last="Wood">William A. Wood</name><affiliation><nlm:affiliation>Division of Hematology/Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC; and.</nlm:affiliation></affiliation></author><author><name sortKey="Artz, Andrew" sort="Artz, Andrew" uniqKey="Artz A" first="Andrew" last="Artz">Andrew Artz</name><affiliation><nlm:affiliation>Section of Hematology/Oncology, University of Chicago School of Medicine, Chicago, IL.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28674027</idno><idno type="pmid">28674027</idno><idno type="doi">10.1182/blood-2017-03-772368</idno><idno type="wicri:Area/PubMed/Corpus">000819</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000819</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Increasing use of allogeneic hematopoietic cell transplantation in patients aged 70 years and older in the United States.</title><author><name sortKey="Muffly, Lori" sort="Muffly, Lori" uniqKey="Muffly L" first="Lori" last="Muffly">Lori Muffly</name><affiliation><nlm:affiliation>Division of Blood and Marrow Transplantation, Stanford University, Stanford, CA.</nlm:affiliation></affiliation></author><author><name sortKey="Pasquini, Marcelo C" sort="Pasquini, Marcelo C" uniqKey="Pasquini M" first="Marcelo C" last="Pasquini">Marcelo C. Pasquini</name><affiliation><nlm:affiliation>Center for International Blood and Marrow Transplant Research and.</nlm:affiliation></affiliation></author><author><name sortKey="Martens, Michael" sort="Martens, Michael" uniqKey="Martens M" first="Michael" last="Martens">Michael Martens</name><affiliation><nlm:affiliation>Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI.</nlm:affiliation></affiliation></author><author><name sortKey="Brazauskas, Ruta" sort="Brazauskas, Ruta" uniqKey="Brazauskas R" first="Ruta" last="Brazauskas">Ruta Brazauskas</name><affiliation><nlm:affiliation>Center for International Blood and Marrow Transplant Research and.</nlm:affiliation></affiliation></author><author><name sortKey="Zhu, Xiaochun" sort="Zhu, Xiaochun" uniqKey="Zhu X" first="Xiaochun" last="Zhu">Xiaochun Zhu</name><affiliation><nlm:affiliation>Center for International Blood and Marrow Transplant Research and.</nlm:affiliation></affiliation></author><author><name sortKey="Adekola, Kehinde" sort="Adekola, Kehinde" uniqKey="Adekola K" first="Kehinde" last="Adekola">Kehinde Adekola</name><affiliation><nlm:affiliation>Northwestern Memorial Hospital, Chicago, IL.</nlm:affiliation></affiliation></author><author><name sortKey="Aljurf, Mahmoud" sort="Aljurf, Mahmoud" uniqKey="Aljurf M" first="Mahmoud" last="Aljurf">Mahmoud Aljurf</name><affiliation><nlm:affiliation>Department of Oncology, King Faisal Specialist Hospital Center and Research, Riyadh, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Ballen, Karen K" sort="Ballen, Karen K" uniqKey="Ballen K" first="Karen K" last="Ballen">Karen K. Ballen</name><affiliation><nlm:affiliation>Department of Hematology/Oncology, Massachusetts General Hospital, Boston, MA.</nlm:affiliation></affiliation></author><author><name sortKey="Bajel, Ashish" sort="Bajel, Ashish" uniqKey="Bajel A" first="Ashish" last="Bajel">Ashish Bajel</name><affiliation><nlm:affiliation>Royal Melbourne Hospital, Victoria, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Baron, Frederic" sort="Baron, Frederic" uniqKey="Baron F" first="Frederic" last="Baron">Frederic Baron</name><affiliation><nlm:affiliation>Centre Hospitalier Universitaire de Liege, Domaine Universitaire du Sart Tilman, Liege, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Battiwalla, Minoo" sort="Battiwalla, Minoo" uniqKey="Battiwalla M" first="Minoo" last="Battiwalla">Minoo Battiwalla</name><affiliation><nlm:affiliation>Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD.</nlm:affiliation></affiliation></author><author><name sortKey="Beitinjaneh, Amer" sort="Beitinjaneh, Amer" uniqKey="Beitinjaneh A" first="Amer" last="Beitinjaneh">Amer Beitinjaneh</name><affiliation><nlm:affiliation>Department of Hematology and Oncology, University of Miami, Miami, FL.</nlm:affiliation></affiliation></author><author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name><affiliation><nlm:affiliation>Department of Hematology, University Hospital, Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Carabasi, Mathew" sort="Carabasi, Mathew" uniqKey="Carabasi M" first="Mathew" last="Carabasi">Mathew Carabasi</name><affiliation><nlm:affiliation>Department of Medical Oncology, Thomas Jefferson University Hospital, Philadelphia, PA.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Yi Bin" sort="Chen, Yi Bin" uniqKey="Chen Y" first="Yi-Bin" last="Chen">Yi-Bin Chen</name><affiliation><nlm:affiliation>Division of Hematology/Oncology, Massachusetts General Hospital, Boston, MA.</nlm:affiliation></affiliation></author><author><name sortKey="Chhabra, Saurabh" sort="Chhabra, Saurabh" uniqKey="Chhabra S" first="Saurabh" last="Chhabra">Saurabh Chhabra</name><affiliation><nlm:affiliation>Department of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI.</nlm:affiliation></affiliation></author><author><name sortKey="Ciurea, Stefan" sort="Ciurea, Stefan" uniqKey="Ciurea S" first="Stefan" last="Ciurea">Stefan Ciurea</name><affiliation><nlm:affiliation>Department of Stem Cell Transplantation and Cellular Therapy and.</nlm:affiliation></affiliation></author><author><name sortKey="Copelan, Edward" sort="Copelan, Edward" uniqKey="Copelan E" first="Edward" last="Copelan">Edward Copelan</name><affiliation><nlm:affiliation>Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC.</nlm:affiliation></affiliation></author><author><name sortKey="D Souza, Anita" sort="D Souza, Anita" uniqKey="D Souza A" first="Anita" last="D'Souza">Anita D'Souza</name><affiliation><nlm:affiliation>Center for International Blood and Marrow Transplant Research and.</nlm:affiliation></affiliation></author><author><name sortKey="Edwards, John" sort="Edwards, John" uniqKey="Edwards J" first="John" last="Edwards">John Edwards</name><affiliation><nlm:affiliation>Indiana Blood and Marrow Transplantation, Indianapolis, IN.</nlm:affiliation></affiliation></author><author><name sortKey="Foran, James" sort="Foran, James" uniqKey="Foran J" first="James" last="Foran">James Foran</name><affiliation><nlm:affiliation>Mayo Clinic, Jacksonville, FL.</nlm:affiliation></affiliation></author><author><name sortKey="Freytes, Cesar O" sort="Freytes, Cesar O" uniqKey="Freytes C" first="Cesar O" last="Freytes">Cesar O. Freytes</name><affiliation><nlm:affiliation>Texas Transplant Institute, San Antonio, TX.</nlm:affiliation></affiliation></author><author><name sortKey="Fung, Henry C" sort="Fung, Henry C" uniqKey="Fung H" first="Henry C" last="Fung">Henry C. Fung</name><affiliation><nlm:affiliation>Department of Medical Oncology, Fox Chase Cancer Center, Temple Health, Philadelphia, PA.</nlm:affiliation></affiliation></author><author><name sortKey="Gale, Robert Peter" sort="Gale, Robert Peter" uniqKey="Gale R" first="Robert Peter" last="Gale">Robert Peter Gale</name><affiliation><nlm:affiliation>Hematology Research Centre, Division of Experimental Medicine, Department of Medicine, Imperial College London, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Giralt, Sergio" sort="Giralt, Sergio" uniqKey="Giralt S" first="Sergio" last="Giralt">Sergio Giralt</name><affiliation><nlm:affiliation>Memorial Sloan Kettering Cancer Center, New York, NY.</nlm:affiliation></affiliation></author><author><name sortKey="Hashmi, Shahrukh K" sort="Hashmi, Shahrukh K" uniqKey="Hashmi S" first="Shahrukh K" last="Hashmi">Shahrukh K. Hashmi</name><affiliation><nlm:affiliation>Department of Internal Medicine, Mayo Clinic, Minneapolis, MN.</nlm:affiliation></affiliation></author><author><name sortKey="Hildebrandt, Gerhard C" sort="Hildebrandt, Gerhard C" uniqKey="Hildebrandt G" first="Gerhard C" last="Hildebrandt">Gerhard C. Hildebrandt</name><affiliation><nlm:affiliation>Department of Internal Medicine, University of Kentucky Chandler Medical Center, Lexington, KY.</nlm:affiliation></affiliation></author><author><name sortKey="Ho, Vincent" sort="Ho, Vincent" uniqKey="Ho V" first="Vincent" last="Ho">Vincent Ho</name><affiliation><nlm:affiliation>Center for Hematologic Oncology, Dana-Farber Cancer Institute, Boston, MA.</nlm:affiliation></affiliation></author><author><name sortKey="Jakubowski, Ann" sort="Jakubowski, Ann" uniqKey="Jakubowski A" first="Ann" last="Jakubowski">Ann Jakubowski</name><affiliation><nlm:affiliation>Memorial Sloan Kettering Cancer Center, New York, NY.</nlm:affiliation></affiliation></author><author><name sortKey="Lazarus, Hillard" sort="Lazarus, Hillard" uniqKey="Lazarus H" first="Hillard" last="Lazarus">Hillard Lazarus</name><affiliation><nlm:affiliation>Seidman Cancer Center, University Hospitals Cleveland Medical Center, Cleveland, OH.</nlm:affiliation></affiliation></author><author><name sortKey="Luskin, Marlise R" sort="Luskin, Marlise R" uniqKey="Luskin M" first="Marlise R" last="Luskin">Marlise R. Luskin</name><affiliation><nlm:affiliation>Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA.</nlm:affiliation></affiliation></author><author><name sortKey="Martino, Rodrigo" sort="Martino, Rodrigo" uniqKey="Martino R" first="Rodrigo" last="Martino">Rodrigo Martino</name><affiliation><nlm:affiliation>Divison of Clinical Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Maziarz, Richard" sort="Maziarz, Richard" uniqKey="Maziarz R" first="Richard" last="Maziarz">Richard Maziarz</name><affiliation><nlm:affiliation>Adult Blood and Marrow Stem Cell Transplant Program, Knight Cancer Institute, Oregon Health and Science University, Portland, OR.</nlm:affiliation></affiliation></author><author><name sortKey="Mccarthy, Philip" sort="Mccarthy, Philip" uniqKey="Mccarthy P" first="Philip" last="Mccarthy">Philip Mccarthy</name><affiliation><nlm:affiliation>Blood and Marrow Transplant Program, Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY.</nlm:affiliation></affiliation></author><author><name sortKey="Nishihori, Taiga" sort="Nishihori, Taiga" uniqKey="Nishihori T" first="Taiga" last="Nishihori">Taiga Nishihori</name><affiliation><nlm:affiliation>Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.</nlm:affiliation></affiliation></author><author><name sortKey="Olin, Rebecca" sort="Olin, Rebecca" uniqKey="Olin R" first="Rebecca" last="Olin">Rebecca Olin</name><affiliation><nlm:affiliation>Department of Medicine, University of California San Francisco Medical Center, San Francisco, CA.</nlm:affiliation></affiliation></author><author><name sortKey="Olsson, Richard F" sort="Olsson, Richard F" uniqKey="Olsson R" first="Richard F" last="Olsson">Richard F. Olsson</name><affiliation><nlm:affiliation>Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Pawarode, Attaphol" sort="Pawarode, Attaphol" uniqKey="Pawarode A" first="Attaphol" last="Pawarode">Attaphol Pawarode</name><affiliation><nlm:affiliation>Blood and Marrow Transplantation Program, Division of Hematology/Oncology, Department of Internal Medicine, The University of Michigan Medical School, Ann Arbor, MI.</nlm:affiliation></affiliation></author><author><name sortKey="Peres, Edward" sort="Peres, Edward" uniqKey="Peres E" first="Edward" last="Peres">Edward Peres</name><affiliation><nlm:affiliation>Bone Marrow Transplant Program, Henry Ford Hospital, Detroit, MI.</nlm:affiliation></affiliation></author><author><name sortKey="Rezvani, Andrew R" sort="Rezvani, Andrew R" uniqKey="Rezvani A" first="Andrew R" last="Rezvani">Andrew R. Rezvani</name><affiliation><nlm:affiliation>Division of Blood and Marrow Transplantation, Stanford University, Stanford, CA.</nlm:affiliation></affiliation></author><author><name sortKey="Rizzieri, David" sort="Rizzieri, David" uniqKey="Rizzieri D" first="David" last="Rizzieri">David Rizzieri</name><affiliation><nlm:affiliation>Division of Hematologic Malignancies and Cellular Therapy, Blood and Marrow Transplant Clinic, Duke University, Durham, NC.</nlm:affiliation></affiliation></author><author><name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N" last="Savani">Bipin N. Savani</name><affiliation><nlm:affiliation>Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.</nlm:affiliation></affiliation></author><author><name sortKey="Schouten, Harry C" sort="Schouten, Harry C" uniqKey="Schouten H" first="Harry C" last="Schouten">Harry C. Schouten</name><affiliation><nlm:affiliation>Department of Hematology, Academische Ziekenhuis, Maastricht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Sabloff, Mitchell" sort="Sabloff, Mitchell" uniqKey="Sabloff M" first="Mitchell" last="Sabloff">Mitchell Sabloff</name><affiliation><nlm:affiliation>Division of Hematology, Department of Medicine, University of Ottawa and Ottawa Hospital Research Institute, Ottawa, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Seftel, Matthew" sort="Seftel, Matthew" uniqKey="Seftel M" first="Matthew" last="Seftel">Matthew Seftel</name><affiliation><nlm:affiliation>Department of Medical Oncology and Hematology, CancerCare Manitoba, Winnipeg, MB, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Seo, Sachiko" sort="Seo, Sachiko" uniqKey="Seo S" first="Sachiko" last="Seo">Sachiko Seo</name><affiliation><nlm:affiliation>National Cancer Research Center, East Hospital, Kashiwa, Chiba, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Sorror, Mohamed L" sort="Sorror, Mohamed L" uniqKey="Sorror M" first="Mohamed L" last="Sorror">Mohamed L. Sorror</name><affiliation><nlm:affiliation>Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA.</nlm:affiliation></affiliation></author><author><name sortKey="Szer, Jeff" sort="Szer, Jeff" uniqKey="Szer J" first="Jeff" last="Szer">Jeff Szer</name><affiliation><nlm:affiliation>Department Clinical Haematology and Bone Marrow Transplantation, Royal Melbourne Hospital, Victoria, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Wirk, Baldeep M" sort="Wirk, Baldeep M" uniqKey="Wirk B" first="Baldeep M" last="Wirk">Baldeep M. Wirk</name><affiliation><nlm:affiliation>Division of Bone Marrow Transplant, Seattle Cancer Care Alliance, Seattle, WA.</nlm:affiliation></affiliation></author><author><name sortKey="Wood, William A" sort="Wood, William A" uniqKey="Wood W" first="William A" last="Wood">William A. Wood</name><affiliation><nlm:affiliation>Division of Hematology/Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC; and.</nlm:affiliation></affiliation></author><author><name sortKey="Artz, Andrew" sort="Artz, Andrew" uniqKey="Artz A" first="Andrew" last="Artz">Andrew Artz</name><affiliation><nlm:affiliation>Section of Hematology/Oncology, University of Chicago School of Medicine, Chicago, IL.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Blood</title><idno type="eISSN">1528-0020</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Cohort Studies</term><term>Demography</term><term>Female</term><term>Hematopoietic Stem Cell Transplantation (mortality)</term><term>Hematopoietic Stem Cell Transplantation (utilization)</term><term>Humans</term><term>Male</term><term>Multivariate Analysis</term><term>Prognosis</term><term>Time Factors</term><term>Transplantation, Homologous (mortality)</term><term>Treatment Outcome</term><term>United States</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Hematopoietic Stem Cell Transplantation</term><term>Transplantation, Homologous</term></keywords><keywords scheme="MESH" qualifier="utilization" xml:lang="en"><term>Hematopoietic Stem Cell Transplantation</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Cohort Studies</term><term>Demography</term><term>Female</term><term>Humans</term><term>Male</term><term>Multivariate Analysis</term><term>Prognosis</term><term>Time Factors</term><term>Treatment Outcome</term><term>United States</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In this study, we evaluated trends and outcomes of allogeneic hematopoietic cell transplantation (HCT) in adults ≥70 years with hematologic malignancies across the United States. Adults ≥70 years with a hematologic malignancy undergoing first allogeneic HCT in the United States between 2000 and 2013 and reported to the Center for International Blood and Marrow Transplant Research were eligible. Transplant utilization and transplant outcomes, including overall survival (OS), progression-free survival (PFS), and transplant-related mortality (TRM) were studied. One thousand one hundred and six patients ≥70 years underwent HCT across 103 transplant centers. The number and proportion of allografts performed in this population rose markedly over the past decade, accounting for 0.1% of transplants in 2000 to 3.85% (N = 298) in 2013. Acute myeloid leukemia and myelodysplastic syndromes represented the most common disease indications. Two-year OS and PFS significantly improved over time (OS: 26% [95% confidence interval (CI), 21% to 33%] in 2000-2007 to 39% [95% CI, 35% to 42%] in 2008-2013, P < .001; PFS: 22% [16% to 28%] in 2000-2007 to 32% [95% CI, 29% to 36%] in 2008-2013, P = .003). Two-year TRM ranged from 33% to 35% and was unchanged over time (P = .54). Multivariable analysis of OS in the modern era of 2008-2013 revealed higher comorbidity by HCT comorbidity index ≥3 (hazard ratio [HR], 1.27; P = .006), umbilical cord blood graft (HR, 1.97; P = .0002), and myeloablative conditioning (HR, 1.61; P = .0002) as adverse factors. Over the past decade, utilization and survival after allogeneic transplant have increased in patients ≥70 years. Select adults ≥70 years with hematologic malignancies should be considered for transplant.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28674027</PMID><DateCreated><Year>2017</Year><Month>07</Month><Day>04</Day></DateCreated><DateCompleted><Year>2017</Year><Month>09</Month><Day>25</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1528-0020</ISSN><JournalIssue CitedMedium="Internet"><Volume>130</Volume><Issue>9</Issue><PubDate><Year>2017</Year><Month>Aug</Month><Day>31</Day></PubDate></JournalIssue><Title>Blood</Title><ISOAbbreviation>Blood</ISOAbbreviation></Journal><ArticleTitle>Increasing use of allogeneic hematopoietic cell transplantation in patients aged 70 years and older in the United States.</ArticleTitle><Pagination><MedlinePgn>1156-1164</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1182/blood-2017-03-772368</ELocationID><Abstract><AbstractText>In this study, we evaluated trends and outcomes of allogeneic hematopoietic cell transplantation (HCT) in adults ≥70 years with hematologic malignancies across the United States. Adults ≥70 years with a hematologic malignancy undergoing first allogeneic HCT in the United States between 2000 and 2013 and reported to the Center for International Blood and Marrow Transplant Research were eligible. Transplant utilization and transplant outcomes, including overall survival (OS), progression-free survival (PFS), and transplant-related mortality (TRM) were studied. One thousand one hundred and six patients ≥70 years underwent HCT across 103 transplant centers. The number and proportion of allografts performed in this population rose markedly over the past decade, accounting for 0.1% of transplants in 2000 to 3.85% (N = 298) in 2013. Acute myeloid leukemia and myelodysplastic syndromes represented the most common disease indications. Two-year OS and PFS significantly improved over time (OS: 26% [95% confidence interval (CI), 21% to 33%] in 2000-2007 to 39% [95% CI, 35% to 42%] in 2008-2013, P < .001; PFS: 22% [16% to 28%] in 2000-2007 to 32% [95% CI, 29% to 36%] in 2008-2013, P = .003). Two-year TRM ranged from 33% to 35% and was unchanged over time (P = .54). Multivariable analysis of OS in the modern era of 2008-2013 revealed higher comorbidity by HCT comorbidity index ≥3 (hazard ratio [HR], 1.27; P = .006), umbilical cord blood graft (HR, 1.97; P = .0002), and myeloablative conditioning (HR, 1.61; P = .0002) as adverse factors. Over the past decade, utilization and survival after allogeneic transplant have increased in patients ≥70 years. Select adults ≥70 years with hematologic malignancies should be considered for transplant.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Muffly</LastName><ForeName>Lori</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Division of Blood and Marrow Transplantation, Stanford University, Stanford, CA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pasquini</LastName><ForeName>Marcelo C</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Center for International Blood and Marrow Transplant Research and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martens</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brazauskas</LastName><ForeName>Ruta</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Center for International Blood and Marrow Transplant Research and.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhu</LastName><ForeName>Xiaochun</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Center for International Blood and Marrow Transplant Research and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Adekola</LastName><ForeName>Kehinde</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Northwestern Memorial Hospital, Chicago, IL.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aljurf</LastName><ForeName>Mahmoud</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Oncology, King Faisal Specialist Hospital Center and Research, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ballen</LastName><ForeName>Karen K</ForeName><Initials>KK</Initials><AffiliationInfo><Affiliation>Department of Hematology/Oncology, Massachusetts General Hospital, Boston, MA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bajel</LastName><ForeName>Ashish</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Royal Melbourne Hospital, Victoria, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baron</LastName><ForeName>Frederic</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Centre Hospitalier Universitaire de Liege, Domaine Universitaire du Sart Tilman, Liege, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Battiwalla</LastName><ForeName>Minoo</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beitinjaneh</LastName><ForeName>Amer</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Hematology and Oncology, University of Miami, Miami, FL.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cahn</LastName><ForeName>Jean-Yves</ForeName><Initials>JY</Initials><AffiliationInfo><Affiliation>Department of Hematology, University Hospital, Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carabasi</LastName><ForeName>Mathew</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medical Oncology, Thomas Jefferson University Hospital, Philadelphia, PA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Yi-Bin</ForeName><Initials>YB</Initials><AffiliationInfo><Affiliation>Division of Hematology/Oncology, Massachusetts General Hospital, Boston, MA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chhabra</LastName><ForeName>Saurabh</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ciurea</LastName><ForeName>Stefan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Stem Cell Transplantation and Cellular Therapy and.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Transplant Myeloid Study Group, The University of Texas MD Anderson Cancer Center, Houston, TX.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Copelan</LastName><ForeName>Edward</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>D'Souza</LastName><ForeName>Anita</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Center for International Blood and Marrow Transplant Research and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Edwards</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Indiana Blood and Marrow Transplantation, Indianapolis, IN.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Foran</LastName><ForeName>James</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Mayo Clinic, Jacksonville, FL.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Freytes</LastName><ForeName>Cesar O</ForeName><Initials>CO</Initials><AffiliationInfo><Affiliation>Texas Transplant Institute, San Antonio, TX.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fung</LastName><ForeName>Henry C</ForeName><Initials>HC</Initials><AffiliationInfo><Affiliation>Department of Medical Oncology, Fox Chase Cancer Center, Temple Health, Philadelphia, PA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gale</LastName><ForeName>Robert Peter</ForeName><Initials>RP</Initials><AffiliationInfo><Affiliation>Hematology Research Centre, Division of Experimental Medicine, Department of Medicine, Imperial College London, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giralt</LastName><ForeName>Sergio</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Memorial Sloan Kettering Cancer Center, New York, NY.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hashmi</LastName><ForeName>Shahrukh K</ForeName><Initials>SK</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Mayo Clinic, Minneapolis, MN.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Oncology Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hildebrandt</LastName><ForeName>Gerhard C</ForeName><Initials>GC</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, University of Kentucky Chandler Medical Center, Lexington, KY.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ho</LastName><ForeName>Vincent</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Center for Hematologic Oncology, Dana-Farber Cancer Institute, Boston, MA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jakubowski</LastName><ForeName>Ann</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Memorial Sloan Kettering Cancer Center, New York, NY.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lazarus</LastName><ForeName>Hillard</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Seidman Cancer Center, University Hospitals Cleveland Medical Center, Cleveland, OH.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Luskin</LastName><ForeName>Marlise R</ForeName><Initials>MR</Initials><AffiliationInfo><Affiliation>Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martino</LastName><ForeName>Rodrigo</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Divison of Clinical Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maziarz</LastName><ForeName>Richard</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Adult Blood and Marrow Stem Cell Transplant Program, Knight Cancer Institute, Oregon Health and Science University, Portland, OR.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McCarthy</LastName><ForeName>Philip</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Blood and Marrow Transplant Program, Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nishihori</LastName><ForeName>Taiga</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Olin</LastName><ForeName>Rebecca</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Medicine, University of California San Francisco Medical Center, San Francisco, CA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Olsson</LastName><ForeName>Richard F</ForeName><Initials>RF</Initials><AffiliationInfo><Affiliation>Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center for Clinical Research Sormland, Uppsala University, Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pawarode</LastName><ForeName>Attaphol</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Blood and Marrow Transplantation Program, Division of Hematology/Oncology, Department of Internal Medicine, The University of Michigan Medical School, Ann Arbor, MI.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peres</LastName><ForeName>Edward</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Bone Marrow Transplant Program, Henry Ford Hospital, Detroit, MI.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rezvani</LastName><ForeName>Andrew R</ForeName><Initials>AR</Initials><AffiliationInfo><Affiliation>Division of Blood and Marrow Transplantation, Stanford University, Stanford, CA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rizzieri</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Division of Hematologic Malignancies and Cellular Therapy, Blood and Marrow Transplant Clinic, Duke University, Durham, NC.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Savani</LastName><ForeName>Bipin N</ForeName><Initials>BN</Initials><AffiliationInfo><Affiliation>Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schouten</LastName><ForeName>Harry C</ForeName><Initials>HC</Initials><AffiliationInfo><Affiliation>Department of Hematology, Academische Ziekenhuis, Maastricht, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sabloff</LastName><ForeName>Mitchell</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Hematology, Department of Medicine, University of Ottawa and Ottawa Hospital Research Institute, Ottawa, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seftel</LastName><ForeName>Matthew</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medical Oncology and Hematology, CancerCare Manitoba, Winnipeg, MB, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seo</LastName><ForeName>Sachiko</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>National Cancer Research Center, East Hospital, Kashiwa, Chiba, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sorror</LastName><ForeName>Mohamed L</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Medical Oncology, Department of Medicine, University of Washington School of Medicine, Seattle, WA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Szer</LastName><ForeName>Jeff</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department Clinical Haematology and Bone Marrow Transplantation, Royal Melbourne Hospital, Victoria, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wirk</LastName><ForeName>Baldeep M</ForeName><Initials>BM</Initials><AffiliationInfo><Affiliation>Division of Bone Marrow Transplant, Seattle Cancer Care Alliance, Seattle, WA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wood</LastName><ForeName>William A</ForeName><Initials>WA</Initials><AffiliationInfo><Affiliation>Division of Hematology/Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC; and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Artz</LastName><ForeName>Andrew</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Section of Hematology/Oncology, University of Chicago School of Medicine, Chicago, IL.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>U10 HL069294</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U24 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Outcome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014481" MajorTopicYN="N">United States</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>03</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>06</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="pmc-release"><Year>2018</Year><Month>08</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>7</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>9</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>7</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId 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