Does Osmotic Stress Affect Natural Product Expression in Fungi?
Identifieur interne : 000792 ( PubMed/Corpus ); précédent : 000791; suivant : 000793Does Osmotic Stress Affect Natural Product Expression in Fungi?
Auteurs : David Overy ; Hebelin Correa ; Catherine Roullier ; Wei-Chiung Chi ; Ka-Lai Pang ; Mostafa Rateb ; Rainer Ebel ; Zhuo Shang ; Rob Capon ; Gerald Bills ; Russell KerrSource :
- Marine drugs [ 1660-3397 ] ; 2017.
Abstract
The discovery of new natural products from fungi isolated from the marine environment has increased dramatically over the last few decades, leading to the identification of over 1000 new metabolites. However, most of the reported marine-derived species appear to be terrestrial in origin yet at the same time, facultatively halo- or osmotolerant. An unanswered question regarding the apparent chemical productivity of marine-derived fungi is whether the common practice of fermenting strains in seawater contributes to enhanced secondary metabolism? To answer this question, a terrestrial isolate of Aspergillus aculeatus was fermented in osmotic and saline stress conditions in parallel across multiple sites. The ex-type strain of A. aculeatus was obtained from three different culture collections. Site-to-site variations in metabolite expression were observed, suggesting that subculturing of the same strain and subtle variations in experimental protocols can have pronounced effects upon metabolite expression. Replicated experiments at individual sites indicated that secondary metabolite production was divergent between osmotic and saline treatments. Titers of some metabolites increased or decreased in response to increasing osmolite (salt or glycerol) concentrations. Furthermore, in some cases, the expression of some secondary metabolites in relation to osmotic and saline stress was attributed to specific sources of the ex-type strains.
DOI: 10.3390/md15080254
PubMed: 28805714
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Does Osmotic Stress Affect Natural Product Expression in Fungi?</title><author><name sortKey="Overy, David" sort="Overy, David" uniqKey="Overy D" first="David" last="Overy">David Overy</name><affiliation><nlm:affiliation>Department of Chemistry, University of Prince Edward Island, 550 University Avenue, Charlottetown, PE C1A 4P3, Canada. david.overy@canada.ca.</nlm:affiliation></affiliation></author><author><name sortKey="Correa, Hebelin" sort="Correa, Hebelin" uniqKey="Correa H" first="Hebelin" last="Correa">Hebelin Correa</name><affiliation><nlm:affiliation>Department of Chemistry, University of Prince Edward Island, 550 University Avenue, Charlottetown, PE C1A 4P3, Canada. hcorreav@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Roullier, Catherine" sort="Roullier, Catherine" uniqKey="Roullier C" first="Catherine" last="Roullier">Catherine Roullier</name><affiliation><nlm:affiliation>Mer Molécules Santé-EA 2160, UFR des Sciences Pharmaceutiques et Biologiques, Université de Nantes, 9 Rue Bias, 44035 Nantes, France. catherine.roullier@univ-nantes.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Chi, Wei Chiung" sort="Chi, Wei Chiung" uniqKey="Chi W" first="Wei-Chiung" last="Chi">Wei-Chiung Chi</name><affiliation><nlm:affiliation>Department of Food Science, National Quemoy University, Kinmen County 89250, Taiwan. joan@nqu.edu.tw.</nlm:affiliation></affiliation></author><author><name sortKey="Pang, Ka Lai" sort="Pang, Ka Lai" uniqKey="Pang K" first="Ka-Lai" last="Pang">Ka-Lai Pang</name><affiliation><nlm:affiliation>Institute of Marine Biology and Centre of Excellence for the Oceans, National Taiwan Ocean University, 2 Pei-Ning Road, Keelung 20224, Taiwan. klpang@mail.ntou.edu.tw.</nlm:affiliation></affiliation></author><author><name sortKey="Rateb, Mostafa" sort="Rateb, Mostafa" uniqKey="Rateb M" first="Mostafa" last="Rateb">Mostafa Rateb</name><affiliation><nlm:affiliation>Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Meston Walk, Aberdeen AB24 3UE, Scotland, UK. m.rateb@abdn.ac.uk.</nlm:affiliation></affiliation></author><author><name sortKey="Ebel, Rainer" sort="Ebel, Rainer" uniqKey="Ebel R" first="Rainer" last="Ebel">Rainer Ebel</name><affiliation><nlm:affiliation>Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Meston Walk, Aberdeen AB24 3UE, Scotland, UK. r.ebel@abdn.ac.uk.</nlm:affiliation></affiliation></author><author><name sortKey="Shang, Zhuo" sort="Shang, Zhuo" uniqKey="Shang Z" first="Zhuo" last="Shang">Zhuo Shang</name><affiliation><nlm:affiliation>Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, 306 Carmody Road, St. Lucia QLD 4072, Australia. z3shang@ucsd.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Capon, Rob" sort="Capon, Rob" uniqKey="Capon R" first="Rob" last="Capon">Rob Capon</name><affiliation><nlm:affiliation>Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, 306 Carmody Road, St. Lucia QLD 4072, Australia. r.capon@uq.edu.au.</nlm:affiliation></affiliation></author><author><name sortKey="Bills, Gerald" sort="Bills, Gerald" uniqKey="Bills G" first="Gerald" last="Bills">Gerald Bills</name><affiliation><nlm:affiliation>Texas Therapeutics Institute, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, 1881 East Rd., Houston, TX 77054, USA. Gerald.F.Bills@uth.tmc.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Kerr, Russell" sort="Kerr, Russell" uniqKey="Kerr R" first="Russell" last="Kerr">Russell Kerr</name><affiliation><nlm:affiliation>Department of Chemistry, University of Prince Edward Island, 550 University Avenue, Charlottetown, PE C1A 4P3, Canada. rkerr@upei.ca.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28805714</idno><idno type="pmid">28805714</idno><idno type="doi">10.3390/md15080254</idno><idno type="wicri:Area/PubMed/Corpus">000792</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000792</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Does Osmotic Stress Affect Natural Product Expression in Fungi?</title><author><name sortKey="Overy, David" sort="Overy, David" uniqKey="Overy D" first="David" last="Overy">David Overy</name><affiliation><nlm:affiliation>Department of Chemistry, University of Prince Edward Island, 550 University Avenue, Charlottetown, PE C1A 4P3, Canada. david.overy@canada.ca.</nlm:affiliation></affiliation></author><author><name sortKey="Correa, Hebelin" sort="Correa, Hebelin" uniqKey="Correa H" first="Hebelin" last="Correa">Hebelin Correa</name><affiliation><nlm:affiliation>Department of Chemistry, University of Prince Edward Island, 550 University Avenue, Charlottetown, PE C1A 4P3, Canada. hcorreav@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Roullier, Catherine" sort="Roullier, Catherine" uniqKey="Roullier C" first="Catherine" last="Roullier">Catherine Roullier</name><affiliation><nlm:affiliation>Mer Molécules Santé-EA 2160, UFR des Sciences Pharmaceutiques et Biologiques, Université de Nantes, 9 Rue Bias, 44035 Nantes, France. catherine.roullier@univ-nantes.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Chi, Wei Chiung" sort="Chi, Wei Chiung" uniqKey="Chi W" first="Wei-Chiung" last="Chi">Wei-Chiung Chi</name><affiliation><nlm:affiliation>Department of Food Science, National Quemoy University, Kinmen County 89250, Taiwan. joan@nqu.edu.tw.</nlm:affiliation></affiliation></author><author><name sortKey="Pang, Ka Lai" sort="Pang, Ka Lai" uniqKey="Pang K" first="Ka-Lai" last="Pang">Ka-Lai Pang</name><affiliation><nlm:affiliation>Institute of Marine Biology and Centre of Excellence for the Oceans, National Taiwan Ocean University, 2 Pei-Ning Road, Keelung 20224, Taiwan. klpang@mail.ntou.edu.tw.</nlm:affiliation></affiliation></author><author><name sortKey="Rateb, Mostafa" sort="Rateb, Mostafa" uniqKey="Rateb M" first="Mostafa" last="Rateb">Mostafa Rateb</name><affiliation><nlm:affiliation>Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Meston Walk, Aberdeen AB24 3UE, Scotland, UK. m.rateb@abdn.ac.uk.</nlm:affiliation></affiliation></author><author><name sortKey="Ebel, Rainer" sort="Ebel, Rainer" uniqKey="Ebel R" first="Rainer" last="Ebel">Rainer Ebel</name><affiliation><nlm:affiliation>Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Meston Walk, Aberdeen AB24 3UE, Scotland, UK. r.ebel@abdn.ac.uk.</nlm:affiliation></affiliation></author><author><name sortKey="Shang, Zhuo" sort="Shang, Zhuo" uniqKey="Shang Z" first="Zhuo" last="Shang">Zhuo Shang</name><affiliation><nlm:affiliation>Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, 306 Carmody Road, St. Lucia QLD 4072, Australia. z3shang@ucsd.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Capon, Rob" sort="Capon, Rob" uniqKey="Capon R" first="Rob" last="Capon">Rob Capon</name><affiliation><nlm:affiliation>Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, 306 Carmody Road, St. Lucia QLD 4072, Australia. r.capon@uq.edu.au.</nlm:affiliation></affiliation></author><author><name sortKey="Bills, Gerald" sort="Bills, Gerald" uniqKey="Bills G" first="Gerald" last="Bills">Gerald Bills</name><affiliation><nlm:affiliation>Texas Therapeutics Institute, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, 1881 East Rd., Houston, TX 77054, USA. Gerald.F.Bills@uth.tmc.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Kerr, Russell" sort="Kerr, Russell" uniqKey="Kerr R" first="Russell" last="Kerr">Russell Kerr</name><affiliation><nlm:affiliation>Department of Chemistry, University of Prince Edward Island, 550 University Avenue, Charlottetown, PE C1A 4P3, Canada. rkerr@upei.ca.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Marine drugs</title><idno type="eISSN">1660-3397</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The discovery of new natural products from fungi isolated from the marine environment has increased dramatically over the last few decades, leading to the identification of over 1000 new metabolites. However, most of the reported marine-derived species appear to be terrestrial in origin yet at the same time, facultatively halo- or osmotolerant. An unanswered question regarding the apparent chemical productivity of marine-derived fungi is whether the common practice of fermenting strains in seawater contributes to enhanced secondary metabolism? To answer this question, a terrestrial isolate of Aspergillus aculeatus was fermented in osmotic and saline stress conditions in parallel across multiple sites. The ex-type strain of A. aculeatus was obtained from three different culture collections. Site-to-site variations in metabolite expression were observed, suggesting that subculturing of the same strain and subtle variations in experimental protocols can have pronounced effects upon metabolite expression. Replicated experiments at individual sites indicated that secondary metabolite production was divergent between osmotic and saline treatments. Titers of some metabolites increased or decreased in response to increasing osmolite (salt or glycerol) concentrations. Furthermore, in some cases, the expression of some secondary metabolites in relation to osmotic and saline stress was attributed to specific sources of the ex-type strains.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28805714</PMID><DateCreated><Year>2017</Year><Month>08</Month><Day>14</Day></DateCreated><DateRevised><Year>2017</Year><Month>09</Month><Day>06</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1660-3397</ISSN><JournalIssue CitedMedium="Internet"><Volume>15</Volume><Issue>8</Issue><PubDate><Year>2017</Year><Month>Aug</Month><Day>13</Day></PubDate></JournalIssue><Title>Marine drugs</Title><ISOAbbreviation>Mar Drugs</ISOAbbreviation></Journal><ArticleTitle>Does Osmotic Stress Affect Natural Product Expression in Fungi?</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">E254</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.3390/md15080254</ELocationID><Abstract><AbstractText>The discovery of new natural products from fungi isolated from the marine environment has increased dramatically over the last few decades, leading to the identification of over 1000 new metabolites. However, most of the reported marine-derived species appear to be terrestrial in origin yet at the same time, facultatively halo- or osmotolerant. An unanswered question regarding the apparent chemical productivity of marine-derived fungi is whether the common practice of fermenting strains in seawater contributes to enhanced secondary metabolism? To answer this question, a terrestrial isolate of Aspergillus aculeatus was fermented in osmotic and saline stress conditions in parallel across multiple sites. The ex-type strain of A. aculeatus was obtained from three different culture collections. Site-to-site variations in metabolite expression were observed, suggesting that subculturing of the same strain and subtle variations in experimental protocols can have pronounced effects upon metabolite expression. Replicated experiments at individual sites indicated that secondary metabolite production was divergent between osmotic and saline treatments. Titers of some metabolites increased or decreased in response to increasing osmolite (salt or glycerol) concentrations. Furthermore, in some cases, the expression of some secondary metabolites in relation to osmotic and saline stress was attributed to specific sources of the ex-type strains.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Overy</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Chemistry, University of Prince Edward Island, 550 University Avenue, Charlottetown, PE C1A 4P3, Canada. david.overy@canada.ca.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Pathology and Microbiology, Atlantic Veterinary College, University of PEI, 550 University Avenue, Charlottetown, PE C1A 4P3, Canada. david.overy@canada.ca.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Nautilus Biosciences Canada Inc., 550 University Avenue, Charlottetown, PE C1A 4P3, Canada. david.overy@canada.ca.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Correa</LastName><ForeName>Hebelin</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Chemistry, University of Prince Edward Island, 550 University Avenue, Charlottetown, PE C1A 4P3, Canada. hcorreav@gmail.com.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Nautilus Biosciences Canada Inc., 550 University Avenue, Charlottetown, PE C1A 4P3, Canada. hcorreav@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Roullier</LastName><ForeName>Catherine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Mer Molécules Santé-EA 2160, UFR des Sciences Pharmaceutiques et Biologiques, Université de Nantes, 9 Rue Bias, 44035 Nantes, France. catherine.roullier@univ-nantes.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chi</LastName><ForeName>Wei-Chiung</ForeName><Initials>WC</Initials><AffiliationInfo><Affiliation>Department of Food Science, National Quemoy University, Kinmen County 89250, Taiwan. joan@nqu.edu.tw.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Marine Biology and Centre of Excellence for the Oceans, National Taiwan Ocean University, 2 Pei-Ning Road, Keelung 20224, Taiwan. joan@nqu.edu.tw.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pang</LastName><ForeName>Ka-Lai</ForeName><Initials>KL</Initials><AffiliationInfo><Affiliation>Institute of Marine Biology and Centre of Excellence for the Oceans, National Taiwan Ocean University, 2 Pei-Ning Road, Keelung 20224, Taiwan. klpang@mail.ntou.edu.tw.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rateb</LastName><ForeName>Mostafa</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Meston Walk, Aberdeen AB24 3UE, Scotland, UK. m.rateb@abdn.ac.uk.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Science & Sport, University of the West of Scotland, Paisley PA1 2BE, UK. m.rateb@abdn.ac.uk.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ebel</LastName><ForeName>Rainer</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Meston Walk, Aberdeen AB24 3UE, Scotland, UK. r.ebel@abdn.ac.uk.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shang</LastName><ForeName>Zhuo</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, 306 Carmody Road, St. Lucia QLD 4072, Australia. z3shang@ucsd.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Capon</LastName><ForeName>Rob</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, 306 Carmody Road, St. Lucia QLD 4072, Australia. r.capon@uq.edu.au.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bills</LastName><ForeName>Gerald</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Texas Therapeutics Institute, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, 1881 East Rd., Houston, TX 77054, USA. Gerald.F.Bills@uth.tmc.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kerr</LastName><ForeName>Russell</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Chemistry, University of Prince Edward Island, 550 University Avenue, Charlottetown, PE C1A 4P3, Canada. rkerr@upei.ca.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Nautilus Biosciences Canada Inc., 550 University Avenue, Charlottetown, PE C1A 4P3, Canada. rkerr@upei.ca.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, PE C1A 4P3, Canada. rkerr@upei.ca.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate 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stress</Keyword></KeywordList><CoiStatement>The authors declare no conflict of interest.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>06</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2017</Year><Month>07</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>08</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>8</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>8</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>8</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28805714</ArticleId><ArticleId IdType="pii">md15080254</ArticleId><ArticleId 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