Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells.
Identifieur interne : 000626 ( PubMed/Corpus ); précédent : 000625; suivant : 000627Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells.
Auteurs : Yulong Gao ; Fernando Souza-Fonseca-Guimaraes ; Tobias Bald ; Susanna S. Ng ; Arabella Young ; Shin Foong Ngiow ; Jai Rautela ; Jasmin Straube ; Nic Waddell ; Stephen J. Blake ; Juming Yan ; Laurent Bartholin ; Jason S. Lee ; Eric Vivier ; Kazuyoshi Takeda ; Meriem Messaoudene ; Laurence Zitvogel ; Michele W L. Teng ; Gabrielle T. Belz ; Christian R. Engwerda ; Nicholas D. Huntington ; Kyohei Nakamura ; Michael Hölzel ; Mark J. SmythSource :
- Nature immunology [ 1529-2916 ] ; 2017.
English descriptors
- KwdEn :
- Animals, Case-Control Studies, Cell Line, Tumor, Cellular Reprogramming (immunology), Enzyme-Linked Immunosorbent Assay, Fibrosarcoma (immunology), Flow Cytometry, Gastrointestinal Neoplasms (immunology), Gastrointestinal Stromal Tumors (immunology), Gene Expression Profiling, Humans, Immunity, Innate (immunology), Killer Cells, Natural (cytology), Killer Cells, Natural (immunology), Lymphocytes (cytology), Lymphocytes (immunology), Mice, Neoplasms, Experimental (immunology), Sequence Analysis, RNA, Signal Transduction, Transforming Growth Factor beta (immunology), Tumor Escape (immunology).
- MESH :
- chemical , immunology : Transforming Growth Factor beta.
- cytology : Killer Cells, Natural, Lymphocytes.
- immunology : Cellular Reprogramming, Fibrosarcoma, Gastrointestinal Neoplasms, Gastrointestinal Stromal Tumors, Immunity, Innate, Killer Cells, Natural, Lymphocytes, Neoplasms, Experimental, Tumor Escape.
- Animals, Case-Control Studies, Cell Line, Tumor, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Gene Expression Profiling, Humans, Mice, Sequence Analysis, RNA, Signal Transduction.
Abstract
Avoiding destruction by immune cells is a hallmark of cancer, yet how tumors ultimately evade control by natural killer (NK) cells remains incompletely defined. Using global transcriptomic and flow-cytometry analyses and genetically engineered mouse models, we identified the cytokine-TGF-β-signaling-dependent conversion of NK cells (CD49a(-)CD49b(+)Eomes(+)) into intermediate type 1 innate lymphoid cell (intILC1) (CD49a(+)CD49b(+)Eomes(+)) populations and ILC1 (CD49a(+)CD49b(-)Eomes(int)) populations in the tumor microenvironment. Strikingly, intILC1s and ILC1s were unable to control local tumor growth and metastasis, whereas NK cells favored tumor immunosurveillance. Experiments with an antibody that neutralizes the cytokine TNF suggested that escape from the innate immune system was partially mediated by TNF-producing ILC1s. Our findings provide new insight into the plasticity of group 1 ILCs in the tumor microenvironment and suggest that the TGF-β-driven conversion of NK cells into ILC1s is a previously unknown mechanism by which tumors escape surveillance by the innate immune system.
DOI: 10.1038/ni.3800
PubMed: 28759001
Links to Exploration step
pubmed:28759001Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells.</title><author><name sortKey="Gao, Yulong" sort="Gao, Yulong" uniqKey="Gao Y" first="Yulong" last="Gao">Yulong Gao</name><affiliation><nlm:affiliation>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Souza Fonseca Guimaraes, Fernando" sort="Souza Fonseca Guimaraes, Fernando" uniqKey="Souza Fonseca Guimaraes F" first="Fernando" last="Souza-Fonseca-Guimaraes">Fernando Souza-Fonseca-Guimaraes</name><affiliation><nlm:affiliation>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Bald, Tobias" sort="Bald, Tobias" uniqKey="Bald T" first="Tobias" last="Bald">Tobias Bald</name><affiliation><nlm:affiliation>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Ng, Susanna S" sort="Ng, Susanna S" uniqKey="Ng S" first="Susanna S" last="Ng">Susanna S. Ng</name><affiliation><nlm:affiliation>Immunology and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Young, Arabella" sort="Young, Arabella" uniqKey="Young A" first="Arabella" last="Young">Arabella Young</name><affiliation><nlm:affiliation>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Ngiow, Shin Foong" sort="Ngiow, Shin Foong" uniqKey="Ngiow S" first="Shin Foong" last="Ngiow">Shin Foong Ngiow</name><affiliation><nlm:affiliation>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Rautela, Jai" sort="Rautela, Jai" uniqKey="Rautela J" first="Jai" last="Rautela">Jai Rautela</name><affiliation><nlm:affiliation>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology and The University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Straube, Jasmin" sort="Straube, Jasmin" uniqKey="Straube J" first="Jasmin" last="Straube">Jasmin Straube</name><affiliation><nlm:affiliation>Medical Genomics, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Waddell, Nic" sort="Waddell, Nic" uniqKey="Waddell N" first="Nic" last="Waddell">Nic Waddell</name><affiliation><nlm:affiliation>Medical Genomics, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Blake, Stephen J" sort="Blake, Stephen J" uniqKey="Blake S" first="Stephen J" last="Blake">Stephen J. Blake</name><affiliation><nlm:affiliation>Cancer Immunoregulation and Immunotherapy, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Yan, Juming" sort="Yan, Juming" uniqKey="Yan J" first="Juming" last="Yan">Juming Yan</name><affiliation><nlm:affiliation>School of Medicine, The University of Queensland, Herston, Queensland, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Bartholin, Laurent" sort="Bartholin, Laurent" uniqKey="Bartholin L" first="Laurent" last="Bartholin">Laurent Bartholin</name><affiliation><nlm:affiliation>Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de recherche en cancérologie de Lyon, Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Jason S" sort="Lee, Jason S" uniqKey="Lee J" first="Jason S" last="Lee">Jason S. Lee</name><affiliation><nlm:affiliation>Control of Gene Expression Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Vivier, Eric" sort="Vivier, Eric" uniqKey="Vivier E" first="Eric" last="Vivier">Eric Vivier</name><affiliation><nlm:affiliation>Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Takeda, Kazuyoshi" sort="Takeda, Kazuyoshi" uniqKey="Takeda K" first="Kazuyoshi" last="Takeda">Kazuyoshi Takeda</name><affiliation><nlm:affiliation>Division of Cell Biology, Biomedical Research Center and Department of Biofunctional Microbiota, Graduate School of Medicine, Juntendo University, Bunkyo-ku, Tokyo, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Messaoudene, Meriem" sort="Messaoudene, Meriem" uniqKey="Messaoudene M" first="Meriem" last="Messaoudene">Meriem Messaoudene</name><affiliation><nlm:affiliation>INSERM U1015, Gustave Roussy Cancer Campus, Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Zitvogel, Laurence" sort="Zitvogel, Laurence" uniqKey="Zitvogel L" first="Laurence" last="Zitvogel">Laurence Zitvogel</name><affiliation><nlm:affiliation>Gustave Roussy Cancer Campus, Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Teng, Michele W L" sort="Teng, Michele W L" uniqKey="Teng M" first="Michele W L" last="Teng">Michele W L. Teng</name><affiliation><nlm:affiliation>School of Medicine, The University of Queensland, Herston, Queensland, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Belz, Gabrielle T" sort="Belz, Gabrielle T" uniqKey="Belz G" first="Gabrielle T" last="Belz">Gabrielle T. Belz</name><affiliation><nlm:affiliation>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology and The University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Engwerda, Christian R" sort="Engwerda, Christian R" uniqKey="Engwerda C" first="Christian R" last="Engwerda">Christian R. Engwerda</name><affiliation><nlm:affiliation>Immunology and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Huntington, Nicholas D" sort="Huntington, Nicholas D" uniqKey="Huntington N" first="Nicholas D" last="Huntington">Nicholas D. Huntington</name><affiliation><nlm:affiliation>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology and The University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Nakamura, Kyohei" sort="Nakamura, Kyohei" uniqKey="Nakamura K" first="Kyohei" last="Nakamura">Kyohei Nakamura</name><affiliation><nlm:affiliation>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Holzel, Michael" sort="Holzel, Michael" uniqKey="Holzel M" first="Michael" last="Hölzel">Michael Hölzel</name><affiliation><nlm:affiliation>Unit for RNA Biology, Department of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Smyth, Mark J" sort="Smyth, Mark J" uniqKey="Smyth M" first="Mark J" last="Smyth">Mark J. Smyth</name><affiliation><nlm:affiliation>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28759001</idno><idno type="pmid">28759001</idno><idno type="doi">10.1038/ni.3800</idno><idno type="wicri:Area/PubMed/Corpus">000626</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000626</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells.</title><author><name sortKey="Gao, Yulong" sort="Gao, Yulong" uniqKey="Gao Y" first="Yulong" last="Gao">Yulong Gao</name><affiliation><nlm:affiliation>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Souza Fonseca Guimaraes, Fernando" sort="Souza Fonseca Guimaraes, Fernando" uniqKey="Souza Fonseca Guimaraes F" first="Fernando" last="Souza-Fonseca-Guimaraes">Fernando Souza-Fonseca-Guimaraes</name><affiliation><nlm:affiliation>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Bald, Tobias" sort="Bald, Tobias" uniqKey="Bald T" first="Tobias" last="Bald">Tobias Bald</name><affiliation><nlm:affiliation>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Ng, Susanna S" sort="Ng, Susanna S" uniqKey="Ng S" first="Susanna S" last="Ng">Susanna S. Ng</name><affiliation><nlm:affiliation>Immunology and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Young, Arabella" sort="Young, Arabella" uniqKey="Young A" first="Arabella" last="Young">Arabella Young</name><affiliation><nlm:affiliation>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Ngiow, Shin Foong" sort="Ngiow, Shin Foong" uniqKey="Ngiow S" first="Shin Foong" last="Ngiow">Shin Foong Ngiow</name><affiliation><nlm:affiliation>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Rautela, Jai" sort="Rautela, Jai" uniqKey="Rautela J" first="Jai" last="Rautela">Jai Rautela</name><affiliation><nlm:affiliation>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology and The University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Straube, Jasmin" sort="Straube, Jasmin" uniqKey="Straube J" first="Jasmin" last="Straube">Jasmin Straube</name><affiliation><nlm:affiliation>Medical Genomics, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Waddell, Nic" sort="Waddell, Nic" uniqKey="Waddell N" first="Nic" last="Waddell">Nic Waddell</name><affiliation><nlm:affiliation>Medical Genomics, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Blake, Stephen J" sort="Blake, Stephen J" uniqKey="Blake S" first="Stephen J" last="Blake">Stephen J. Blake</name><affiliation><nlm:affiliation>Cancer Immunoregulation and Immunotherapy, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Yan, Juming" sort="Yan, Juming" uniqKey="Yan J" first="Juming" last="Yan">Juming Yan</name><affiliation><nlm:affiliation>School of Medicine, The University of Queensland, Herston, Queensland, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Bartholin, Laurent" sort="Bartholin, Laurent" uniqKey="Bartholin L" first="Laurent" last="Bartholin">Laurent Bartholin</name><affiliation><nlm:affiliation>Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de recherche en cancérologie de Lyon, Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Jason S" sort="Lee, Jason S" uniqKey="Lee J" first="Jason S" last="Lee">Jason S. Lee</name><affiliation><nlm:affiliation>Control of Gene Expression Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Vivier, Eric" sort="Vivier, Eric" uniqKey="Vivier E" first="Eric" last="Vivier">Eric Vivier</name><affiliation><nlm:affiliation>Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Takeda, Kazuyoshi" sort="Takeda, Kazuyoshi" uniqKey="Takeda K" first="Kazuyoshi" last="Takeda">Kazuyoshi Takeda</name><affiliation><nlm:affiliation>Division of Cell Biology, Biomedical Research Center and Department of Biofunctional Microbiota, Graduate School of Medicine, Juntendo University, Bunkyo-ku, Tokyo, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Messaoudene, Meriem" sort="Messaoudene, Meriem" uniqKey="Messaoudene M" first="Meriem" last="Messaoudene">Meriem Messaoudene</name><affiliation><nlm:affiliation>INSERM U1015, Gustave Roussy Cancer Campus, Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Zitvogel, Laurence" sort="Zitvogel, Laurence" uniqKey="Zitvogel L" first="Laurence" last="Zitvogel">Laurence Zitvogel</name><affiliation><nlm:affiliation>Gustave Roussy Cancer Campus, Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Teng, Michele W L" sort="Teng, Michele W L" uniqKey="Teng M" first="Michele W L" last="Teng">Michele W L. Teng</name><affiliation><nlm:affiliation>School of Medicine, The University of Queensland, Herston, Queensland, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Belz, Gabrielle T" sort="Belz, Gabrielle T" uniqKey="Belz G" first="Gabrielle T" last="Belz">Gabrielle T. Belz</name><affiliation><nlm:affiliation>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology and The University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Engwerda, Christian R" sort="Engwerda, Christian R" uniqKey="Engwerda C" first="Christian R" last="Engwerda">Christian R. Engwerda</name><affiliation><nlm:affiliation>Immunology and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Huntington, Nicholas D" sort="Huntington, Nicholas D" uniqKey="Huntington N" first="Nicholas D" last="Huntington">Nicholas D. Huntington</name><affiliation><nlm:affiliation>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology and The University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Nakamura, Kyohei" sort="Nakamura, Kyohei" uniqKey="Nakamura K" first="Kyohei" last="Nakamura">Kyohei Nakamura</name><affiliation><nlm:affiliation>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Holzel, Michael" sort="Holzel, Michael" uniqKey="Holzel M" first="Michael" last="Hölzel">Michael Hölzel</name><affiliation><nlm:affiliation>Unit for RNA Biology, Department of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Smyth, Mark J" sort="Smyth, Mark J" uniqKey="Smyth M" first="Mark J" last="Smyth">Mark J. Smyth</name><affiliation><nlm:affiliation>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Nature immunology</title><idno type="eISSN">1529-2916</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Case-Control Studies</term><term>Cell Line, Tumor</term><term>Cellular Reprogramming (immunology)</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Fibrosarcoma (immunology)</term><term>Flow Cytometry</term><term>Gastrointestinal Neoplasms (immunology)</term><term>Gastrointestinal Stromal Tumors (immunology)</term><term>Gene Expression Profiling</term><term>Humans</term><term>Immunity, Innate (immunology)</term><term>Killer Cells, Natural (cytology)</term><term>Killer Cells, Natural (immunology)</term><term>Lymphocytes (cytology)</term><term>Lymphocytes (immunology)</term><term>Mice</term><term>Neoplasms, Experimental (immunology)</term><term>Sequence Analysis, RNA</term><term>Signal Transduction</term><term>Transforming Growth Factor beta (immunology)</term><term>Tumor Escape (immunology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Transforming Growth Factor beta</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Killer Cells, Natural</term><term>Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Cellular Reprogramming</term><term>Fibrosarcoma</term><term>Gastrointestinal Neoplasms</term><term>Gastrointestinal Stromal Tumors</term><term>Immunity, Innate</term><term>Killer Cells, Natural</term><term>Lymphocytes</term><term>Neoplasms, Experimental</term><term>Tumor Escape</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Case-Control Studies</term><term>Cell Line, Tumor</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Flow Cytometry</term><term>Gene Expression Profiling</term><term>Humans</term><term>Mice</term><term>Sequence Analysis, RNA</term><term>Signal Transduction</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Avoiding destruction by immune cells is a hallmark of cancer, yet how tumors ultimately evade control by natural killer (NK) cells remains incompletely defined. Using global transcriptomic and flow-cytometry analyses and genetically engineered mouse models, we identified the cytokine-TGF-β-signaling-dependent conversion of NK cells (CD49a(-)CD49b(+)Eomes(+)) into intermediate type 1 innate lymphoid cell (intILC1) (CD49a(+)CD49b(+)Eomes(+)) populations and ILC1 (CD49a(+)CD49b(-)Eomes(int)) populations in the tumor microenvironment. Strikingly, intILC1s and ILC1s were unable to control local tumor growth and metastasis, whereas NK cells favored tumor immunosurveillance. Experiments with an antibody that neutralizes the cytokine TNF suggested that escape from the innate immune system was partially mediated by TNF-producing ILC1s. Our findings provide new insight into the plasticity of group 1 ILCs in the tumor microenvironment and suggest that the TGF-β-driven conversion of NK cells into ILC1s is a previously unknown mechanism by which tumors escape surveillance by the innate immune system.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28759001</PMID><DateCreated><Year>2017</Year><Month>07</Month><Day>31</Day></DateCreated><DateCompleted><Year>2017</Year><Month>09</Month><Day>11</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>11</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1529-2916</ISSN><JournalIssue CitedMedium="Internet"><Volume>18</Volume><Issue>9</Issue><PubDate><Year>2017</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Nature immunology</Title><ISOAbbreviation>Nat. Immunol.</ISOAbbreviation></Journal><ArticleTitle>Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells.</ArticleTitle><Pagination><MedlinePgn>1004-1015</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/ni.3800</ELocationID><Abstract><AbstractText>Avoiding destruction by immune cells is a hallmark of cancer, yet how tumors ultimately evade control by natural killer (NK) cells remains incompletely defined. Using global transcriptomic and flow-cytometry analyses and genetically engineered mouse models, we identified the cytokine-TGF-β-signaling-dependent conversion of NK cells (CD49a(-)CD49b(+)Eomes(+)) into intermediate type 1 innate lymphoid cell (intILC1) (CD49a(+)CD49b(+)Eomes(+)) populations and ILC1 (CD49a(+)CD49b(-)Eomes(int)) populations in the tumor microenvironment. Strikingly, intILC1s and ILC1s were unable to control local tumor growth and metastasis, whereas NK cells favored tumor immunosurveillance. Experiments with an antibody that neutralizes the cytokine TNF suggested that escape from the innate immune system was partially mediated by TNF-producing ILC1s. Our findings provide new insight into the plasticity of group 1 ILCs in the tumor microenvironment and suggest that the TGF-β-driven conversion of NK cells into ILC1s is a previously unknown mechanism by which tumors escape surveillance by the innate immune system.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gao</LastName><ForeName>Yulong</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Medicine, The University of Queensland, Herston, Queensland, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Souza-Fonseca-Guimaraes</LastName><ForeName>Fernando</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology and The University of Melbourne, Parkville, Victoria, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bald</LastName><ForeName>Tobias</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ng</LastName><ForeName>Susanna S</ForeName><Initials>SS</Initials><AffiliationInfo><Affiliation>Immunology and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Natural Sciences, Griffith University, Nathan, Queensland, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Young</LastName><ForeName>Arabella</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Medicine, The University of Queensland, Herston, Queensland, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ngiow</LastName><ForeName>Shin Foong</ForeName><Initials>SF</Initials><AffiliationInfo><Affiliation>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rautela</LastName><ForeName>Jai</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology and The University of Melbourne, Parkville, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Straube</LastName><ForeName>Jasmin</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Medical Genomics, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Waddell</LastName><ForeName>Nic</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Medical Genomics, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blake</LastName><ForeName>Stephen J</ForeName><Initials>SJ</Initials><AffiliationInfo><Affiliation>Cancer 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Source="ORCID">http://orcid.org/0000-0003-0879-934X</Identifier><AffiliationInfo><Affiliation>Control of Gene Expression Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vivier</LastName><ForeName>Eric</ForeName><Initials>E</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-7022-8287</Identifier><AffiliationInfo><Affiliation>Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Takeda</LastName><ForeName>Kazuyoshi</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Division of Cell Biology, Biomedical Research Center and Department of Biofunctional Microbiota, Graduate School of Medicine, Juntendo University, Bunkyo-ku, Tokyo, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Messaoudene</LastName><ForeName>Meriem</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>INSERM U1015, Gustave Roussy Cancer Campus, Villejuif, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Gustave Roussy Cancer Campus, Villejuif, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zitvogel</LastName><ForeName>Laurence</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Gustave Roussy Cancer Campus, Villejuif, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University Paris-Saclay, Kremlin Bicêtre, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CIC1428, Gustave Roussy Cancer Campus, Villejuif, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Teng</LastName><ForeName>Michele W L</ForeName><Initials>MWL</Initials><AffiliationInfo><Affiliation>School of Medicine, The University of Queensland, Herston, Queensland, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Cancer Immunoregulation and Immunotherapy, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Belz</LastName><ForeName>Gabrielle T</ForeName><Initials>GT</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-9660-9587</Identifier><AffiliationInfo><Affiliation>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology and The University of Melbourne, Parkville, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Engwerda</LastName><ForeName>Christian R</ForeName><Initials>CR</Initials><AffiliationInfo><Affiliation>Immunology and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huntington</LastName><ForeName>Nicholas D</ForeName><Initials>ND</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-5267-7211</Identifier><AffiliationInfo><Affiliation>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology and The University of Melbourne, Parkville, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nakamura</LastName><ForeName>Kyohei</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hölzel</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Unit for RNA Biology, Department of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Bonn, Germany.</Affiliation></AffiliationInfo></Author><Author 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