Host Transcription Profile In Nasal Epithelium And Whole Blood of Hospitalised Children under two years of age with Respiratory Syncytial Virus Infection.
Identifieur interne : 000567 ( PubMed/Corpus ); précédent : 000566; suivant : 000568Host Transcription Profile In Nasal Epithelium And Whole Blood of Hospitalised Children under two years of age with Respiratory Syncytial Virus Infection.
Auteurs : Lien Anh Ha Do ; Johann Pellet ; H Rogier Van Doorn ; Anh Tuan Tran ; Bach Hue Nguyen ; Thi Thu Loan Tran ; Quynh Huong Tran ; Quoc Bao Vo ; Nguyen Anh Tran Dac ; Hong Nhien Trinh ; Thi Thanh Hai Nguyen ; Bao Tinh Le Binh ; Huu Mai Khanh Nguyen ; Minh Tien Nguyen ; Quang Tung Thai ; Thanh Vu Vo ; Ngoc Quang Minh Ngo ; Thi Kim Huyen Dang ; Ngoc Huong Cao ; Thu Van Tran ; Lu Viet Ho ; Bertrand De Meulder ; Charles Auffray ; Jorrit-Jan Hofstra ; Jeremy Farrar ; Juliet E. Bryant ; Menno De Jong ; Martin L. HibberdSource :
- The Journal of infectious diseases [ 1537-6613 ] ; 2017.
Abstract
Most insights into the cascade of immune events following acute respiratory syncytial virus (RSV) infection have been obtained from animal experiments or in vitro models. Here we investigated host gene expression profiles in nasopharyngeal swabs (NP) and whole blood samples during natural RSV and rhinovirus (hRV) infection (acute versus early recovery phase) in 83 hospitalised patients <2 years old with lower respiratory tract infections (LRTI). RSV infection induced strong and persistent innate immune responses including interferon signaling and pathways related to chemokine/cytokine signaling in both compartments. Interferon alpha/beta, NOTCH1 signaling pathways and potential biomarkers HIST1H4E, IL7R, ISG15 in NP samples, or BCL6, HIST2H2AC, CCNA1 in blood are leading pathways and hub genes that were associated with both RSV load and severity. The observed RSV-induced gene expression patterns did not differ significantly in NP and blood specimens. In contrast, hRV infection did not as strongly induce expression of innate immunity pathways, and significant differences were observed between NP and blood specimens. We conclude that RSV induced strong and persistent innate immune responses and that RSV severity may be related to development of T follicular helper cells and antiviral inflammatory sequelae derived from high activation of BCL6.
DOI: 10.1093/infdis/jix519
PubMed: 29029245
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Host Transcription Profile In Nasal Epithelium And Whole Blood of Hospitalised Children under two years of age with Respiratory Syncytial Virus Infection.</title><author><name sortKey="Do, Lien Anh Ha" sort="Do, Lien Anh Ha" uniqKey="Do L" first="Lien Anh Ha" last="Do">Lien Anh Ha Do</name><affiliation><nlm:affiliation>Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Pellet, Johann" sort="Pellet, Johann" uniqKey="Pellet J" first="Johann" last="Pellet">Johann Pellet</name><affiliation><nlm:affiliation>European Institute for Systems Biology and Medicine, 50 avenue Tony Garnier, 69007 Lyon - France.</nlm:affiliation></affiliation></author><author><name sortKey="Van Doorn, H Rogier" sort="Van Doorn, H Rogier" uniqKey="Van Doorn H" first="H Rogier" last="Van Doorn">H Rogier Van Doorn</name><affiliation><nlm:affiliation>Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Tran, Anh Tuan" sort="Tran, Anh Tuan" uniqKey="Tran A" first="Anh Tuan" last="Tran">Anh Tuan Tran</name><affiliation><nlm:affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Nguyen, Bach Hue" sort="Nguyen, Bach Hue" uniqKey="Nguyen B" first="Bach Hue" last="Nguyen">Bach Hue Nguyen</name><affiliation><nlm:affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Tran, Thi Thu Loan" sort="Tran, Thi Thu Loan" uniqKey="Tran T" first="Thi Thu Loan" last="Tran">Thi Thu Loan Tran</name><affiliation><nlm:affiliation>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Tran, Quynh Huong" sort="Tran, Quynh Huong" uniqKey="Tran Q" first="Quynh Huong" last="Tran">Quynh Huong Tran</name><affiliation><nlm:affiliation>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Vo, Quoc Bao" sort="Vo, Quoc Bao" uniqKey="Vo Q" first="Quoc Bao" last="Vo">Quoc Bao Vo</name><affiliation><nlm:affiliation>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Tran Dac, Nguyen Anh" sort="Tran Dac, Nguyen Anh" uniqKey="Tran Dac N" first="Nguyen Anh" last="Tran Dac">Nguyen Anh Tran Dac</name><affiliation><nlm:affiliation>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Trinh, Hong Nhien" sort="Trinh, Hong Nhien" uniqKey="Trinh H" first="Hong Nhien" last="Trinh">Hong Nhien Trinh</name><affiliation><nlm:affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Nguyen, Thi Thanh Hai" sort="Nguyen, Thi Thanh Hai" uniqKey="Nguyen T" first="Thi Thanh Hai" last="Nguyen">Thi Thanh Hai Nguyen</name><affiliation><nlm:affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Le Binh, Bao Tinh" sort="Le Binh, Bao Tinh" uniqKey="Le Binh B" first="Bao Tinh" last="Le Binh">Bao Tinh Le Binh</name><affiliation><nlm:affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Nguyen, Huu Mai Khanh" sort="Nguyen, Huu Mai Khanh" uniqKey="Nguyen H" first="Huu Mai Khanh" last="Nguyen">Huu Mai Khanh Nguyen</name><affiliation><nlm:affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Nguyen, Minh Tien" sort="Nguyen, Minh Tien" uniqKey="Nguyen M" first="Minh Tien" last="Nguyen">Minh Tien Nguyen</name><affiliation><nlm:affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Thai, Quang Tung" sort="Thai, Quang Tung" uniqKey="Thai Q" first="Quang Tung" last="Thai">Quang Tung Thai</name><affiliation><nlm:affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Vo, Thanh Vu" sort="Vo, Thanh Vu" uniqKey="Vo T" first="Thanh Vu" last="Vo">Thanh Vu Vo</name><affiliation><nlm:affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Ngo, Ngoc Quang Minh" sort="Ngo, Ngoc Quang Minh" uniqKey="Ngo N" first="Ngoc Quang Minh" last="Ngo">Ngoc Quang Minh Ngo</name><affiliation><nlm:affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Dang, Thi Kim Huyen" sort="Dang, Thi Kim Huyen" uniqKey="Dang T" first="Thi Kim Huyen" last="Dang">Thi Kim Huyen Dang</name><affiliation><nlm:affiliation>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Cao, Ngoc Huong" sort="Cao, Ngoc Huong" uniqKey="Cao N" first="Ngoc Huong" last="Cao">Ngoc Huong Cao</name><affiliation><nlm:affiliation>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Tran, Thu Van" sort="Tran, Thu Van" uniqKey="Tran T" first="Thu Van" last="Tran">Thu Van Tran</name><affiliation><nlm:affiliation>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Ho, Lu Viet" sort="Ho, Lu Viet" uniqKey="Ho L" first="Lu Viet" last="Ho">Lu Viet Ho</name><affiliation><nlm:affiliation>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="De Meulder, Bertrand" sort="De Meulder, Bertrand" uniqKey="De Meulder B" first="Bertrand" last="De Meulder">Bertrand De Meulder</name><affiliation><nlm:affiliation>European Institute for Systems Biology and Medicine, 50 avenue Tony Garnier, 69007 Lyon - France.</nlm:affiliation></affiliation></author><author><name sortKey="Auffray, Charles" sort="Auffray, Charles" uniqKey="Auffray C" first="Charles" last="Auffray">Charles Auffray</name><affiliation><nlm:affiliation>European Institute for Systems Biology and Medicine, 50 avenue Tony Garnier, 69007 Lyon - France.</nlm:affiliation></affiliation></author><author><name sortKey="Hofstra, Jorrit Jan" sort="Hofstra, Jorrit Jan" uniqKey="Hofstra J" first="Jorrit-Jan" last="Hofstra">Jorrit-Jan Hofstra</name><affiliation><nlm:affiliation>Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Farrar, Jeremy" sort="Farrar, Jeremy" uniqKey="Farrar J" first="Jeremy" last="Farrar">Jeremy Farrar</name><affiliation><nlm:affiliation>Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Bryant, Juliet E" sort="Bryant, Juliet E" uniqKey="Bryant J" first="Juliet E" last="Bryant">Juliet E. Bryant</name><affiliation><nlm:affiliation>Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="De Jong, Menno" sort="De Jong, Menno" uniqKey="De Jong M" first="Menno" last="De Jong">Menno De Jong</name><affiliation><nlm:affiliation>Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Hibberd, Martin L" sort="Hibberd, Martin L" uniqKey="Hibberd M" first="Martin L" last="Hibberd">Martin L. Hibberd</name><affiliation><nlm:affiliation>Genome Institute of Singapore, #02-01, Genome Building, 60 Biopolis Street, Singapore 138672.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:29029245</idno><idno type="pmid">29029245</idno><idno type="doi">10.1093/infdis/jix519</idno><idno type="wicri:Area/PubMed/Corpus">000567</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000567</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Host Transcription Profile In Nasal Epithelium And Whole Blood of Hospitalised Children under two years of age with Respiratory Syncytial Virus Infection.</title><author><name sortKey="Do, Lien Anh Ha" sort="Do, Lien Anh Ha" uniqKey="Do L" first="Lien Anh Ha" last="Do">Lien Anh Ha Do</name><affiliation><nlm:affiliation>Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Pellet, Johann" sort="Pellet, Johann" uniqKey="Pellet J" first="Johann" last="Pellet">Johann Pellet</name><affiliation><nlm:affiliation>European Institute for Systems Biology and Medicine, 50 avenue Tony Garnier, 69007 Lyon - France.</nlm:affiliation></affiliation></author><author><name sortKey="Van Doorn, H Rogier" sort="Van Doorn, H Rogier" uniqKey="Van Doorn H" first="H Rogier" last="Van Doorn">H Rogier Van Doorn</name><affiliation><nlm:affiliation>Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Tran, Anh Tuan" sort="Tran, Anh Tuan" uniqKey="Tran A" first="Anh Tuan" last="Tran">Anh Tuan Tran</name><affiliation><nlm:affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Nguyen, Bach Hue" sort="Nguyen, Bach Hue" uniqKey="Nguyen B" first="Bach Hue" last="Nguyen">Bach Hue Nguyen</name><affiliation><nlm:affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Tran, Thi Thu Loan" sort="Tran, Thi Thu Loan" uniqKey="Tran T" first="Thi Thu Loan" last="Tran">Thi Thu Loan Tran</name><affiliation><nlm:affiliation>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Tran, Quynh Huong" sort="Tran, Quynh Huong" uniqKey="Tran Q" first="Quynh Huong" last="Tran">Quynh Huong Tran</name><affiliation><nlm:affiliation>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Vo, Quoc Bao" sort="Vo, Quoc Bao" uniqKey="Vo Q" first="Quoc Bao" last="Vo">Quoc Bao Vo</name><affiliation><nlm:affiliation>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Tran Dac, Nguyen Anh" sort="Tran Dac, Nguyen Anh" uniqKey="Tran Dac N" first="Nguyen Anh" last="Tran Dac">Nguyen Anh Tran Dac</name><affiliation><nlm:affiliation>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Trinh, Hong Nhien" sort="Trinh, Hong Nhien" uniqKey="Trinh H" first="Hong Nhien" last="Trinh">Hong Nhien Trinh</name><affiliation><nlm:affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Nguyen, Thi Thanh Hai" sort="Nguyen, Thi Thanh Hai" uniqKey="Nguyen T" first="Thi Thanh Hai" last="Nguyen">Thi Thanh Hai Nguyen</name><affiliation><nlm:affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Le Binh, Bao Tinh" sort="Le Binh, Bao Tinh" uniqKey="Le Binh B" first="Bao Tinh" last="Le Binh">Bao Tinh Le Binh</name><affiliation><nlm:affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Nguyen, Huu Mai Khanh" sort="Nguyen, Huu Mai Khanh" uniqKey="Nguyen H" first="Huu Mai Khanh" last="Nguyen">Huu Mai Khanh Nguyen</name><affiliation><nlm:affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Nguyen, Minh Tien" sort="Nguyen, Minh Tien" uniqKey="Nguyen M" first="Minh Tien" last="Nguyen">Minh Tien Nguyen</name><affiliation><nlm:affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Thai, Quang Tung" sort="Thai, Quang Tung" uniqKey="Thai Q" first="Quang Tung" last="Thai">Quang Tung Thai</name><affiliation><nlm:affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Vo, Thanh Vu" sort="Vo, Thanh Vu" uniqKey="Vo T" first="Thanh Vu" last="Vo">Thanh Vu Vo</name><affiliation><nlm:affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Ngo, Ngoc Quang Minh" sort="Ngo, Ngoc Quang Minh" uniqKey="Ngo N" first="Ngoc Quang Minh" last="Ngo">Ngoc Quang Minh Ngo</name><affiliation><nlm:affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Dang, Thi Kim Huyen" sort="Dang, Thi Kim Huyen" uniqKey="Dang T" first="Thi Kim Huyen" last="Dang">Thi Kim Huyen Dang</name><affiliation><nlm:affiliation>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Cao, Ngoc Huong" sort="Cao, Ngoc Huong" uniqKey="Cao N" first="Ngoc Huong" last="Cao">Ngoc Huong Cao</name><affiliation><nlm:affiliation>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Tran, Thu Van" sort="Tran, Thu Van" uniqKey="Tran T" first="Thu Van" last="Tran">Thu Van Tran</name><affiliation><nlm:affiliation>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Ho, Lu Viet" sort="Ho, Lu Viet" uniqKey="Ho L" first="Lu Viet" last="Ho">Lu Viet Ho</name><affiliation><nlm:affiliation>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="De Meulder, Bertrand" sort="De Meulder, Bertrand" uniqKey="De Meulder B" first="Bertrand" last="De Meulder">Bertrand De Meulder</name><affiliation><nlm:affiliation>European Institute for Systems Biology and Medicine, 50 avenue Tony Garnier, 69007 Lyon - France.</nlm:affiliation></affiliation></author><author><name sortKey="Auffray, Charles" sort="Auffray, Charles" uniqKey="Auffray C" first="Charles" last="Auffray">Charles Auffray</name><affiliation><nlm:affiliation>European Institute for Systems Biology and Medicine, 50 avenue Tony Garnier, 69007 Lyon - France.</nlm:affiliation></affiliation></author><author><name sortKey="Hofstra, Jorrit Jan" sort="Hofstra, Jorrit Jan" uniqKey="Hofstra J" first="Jorrit-Jan" last="Hofstra">Jorrit-Jan Hofstra</name><affiliation><nlm:affiliation>Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Farrar, Jeremy" sort="Farrar, Jeremy" uniqKey="Farrar J" first="Jeremy" last="Farrar">Jeremy Farrar</name><affiliation><nlm:affiliation>Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Bryant, Juliet E" sort="Bryant, Juliet E" uniqKey="Bryant J" first="Juliet E" last="Bryant">Juliet E. Bryant</name><affiliation><nlm:affiliation>Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="De Jong, Menno" sort="De Jong, Menno" uniqKey="De Jong M" first="Menno" last="De Jong">Menno De Jong</name><affiliation><nlm:affiliation>Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Hibberd, Martin L" sort="Hibberd, Martin L" uniqKey="Hibberd M" first="Martin L" last="Hibberd">Martin L. Hibberd</name><affiliation><nlm:affiliation>Genome Institute of Singapore, #02-01, Genome Building, 60 Biopolis Street, Singapore 138672.</nlm:affiliation></affiliation></author></analytic><series><title level="j">The Journal of infectious diseases</title><idno type="eISSN">1537-6613</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Most insights into the cascade of immune events following acute respiratory syncytial virus (RSV) infection have been obtained from animal experiments or in vitro models. Here we investigated host gene expression profiles in nasopharyngeal swabs (NP) and whole blood samples during natural RSV and rhinovirus (hRV) infection (acute versus early recovery phase) in 83 hospitalised patients <2 years old with lower respiratory tract infections (LRTI). RSV infection induced strong and persistent innate immune responses including interferon signaling and pathways related to chemokine/cytokine signaling in both compartments. Interferon alpha/beta, NOTCH1 signaling pathways and potential biomarkers HIST1H4E, IL7R, ISG15 in NP samples, or BCL6, HIST2H2AC, CCNA1 in blood are leading pathways and hub genes that were associated with both RSV load and severity. The observed RSV-induced gene expression patterns did not differ significantly in NP and blood specimens. In contrast, hRV infection did not as strongly induce expression of innate immunity pathways, and significant differences were observed between NP and blood specimens. We conclude that RSV induced strong and persistent innate immune responses and that RSV severity may be related to development of T follicular helper cells and antiviral inflammatory sequelae derived from high activation of BCL6.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">29029245</PMID><DateCreated><Year>2017</Year><Month>10</Month><Day>13</Day></DateCreated><DateRevised><Year>2017</Year><Month>10</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1537-6613</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2017</Year><Month>Sep</Month><Day>27</Day></PubDate></JournalIssue><Title>The Journal of infectious diseases</Title><ISOAbbreviation>J. Infect. Dis.</ISOAbbreviation></Journal><ArticleTitle>Host Transcription Profile In Nasal Epithelium And Whole Blood of Hospitalised Children under two years of age with Respiratory Syncytial Virus Infection.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1093/infdis/jix519</ELocationID><Abstract><AbstractText>Most insights into the cascade of immune events following acute respiratory syncytial virus (RSV) infection have been obtained from animal experiments or in vitro models. Here we investigated host gene expression profiles in nasopharyngeal swabs (NP) and whole blood samples during natural RSV and rhinovirus (hRV) infection (acute versus early recovery phase) in 83 hospitalised patients <2 years old with lower respiratory tract infections (LRTI). RSV infection induced strong and persistent innate immune responses including interferon signaling and pathways related to chemokine/cytokine signaling in both compartments. Interferon alpha/beta, NOTCH1 signaling pathways and potential biomarkers HIST1H4E, IL7R, ISG15 in NP samples, or BCL6, HIST2H2AC, CCNA1 in blood are leading pathways and hub genes that were associated with both RSV load and severity. The observed RSV-induced gene expression patterns did not differ significantly in NP and blood specimens. In contrast, hRV infection did not as strongly induce expression of innate immunity pathways, and significant differences were observed between NP and blood specimens. We conclude that RSV induced strong and persistent innate immune responses and that RSV severity may be related to development of T follicular helper cells and antiviral inflammatory sequelae derived from high activation of BCL6.</AbstractText><CopyrightInformation>© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Do</LastName><ForeName>Lien Anh Ha</ForeName><Initials>LAH</Initials><AffiliationInfo><Affiliation>Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Murdoch Children's Research Institute, Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pellet</LastName><ForeName>Johann</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>European Institute for Systems Biology and Medicine, 50 avenue Tony Garnier, 69007 Lyon - France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Doorn</LastName><ForeName>H Rogier</ForeName><Initials>HR</Initials><AffiliationInfo><Affiliation>Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tran</LastName><ForeName>Anh Tuan</ForeName><Initials>AT</Initials><AffiliationInfo><Affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nguyen</LastName><ForeName>Bach Hue</ForeName><Initials>BH</Initials><AffiliationInfo><Affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tran</LastName><ForeName>Thi Thu Loan</ForeName><Initials>TTL</Initials><AffiliationInfo><Affiliation>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tran</LastName><ForeName>Quynh Huong</ForeName><Initials>QH</Initials><AffiliationInfo><Affiliation>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vo</LastName><ForeName>Quoc Bao</ForeName><Initials>QB</Initials><AffiliationInfo><Affiliation>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tran Dac</LastName><ForeName>Nguyen Anh</ForeName><Initials>NA</Initials><AffiliationInfo><Affiliation>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Trinh</LastName><ForeName>Hong Nhien</ForeName><Initials>HN</Initials><AffiliationInfo><Affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nguyen</LastName><ForeName>Thi Thanh Hai</ForeName><Initials>TTH</Initials><AffiliationInfo><Affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Le Binh</LastName><ForeName>Bao Tinh</ForeName><Initials>BT</Initials><AffiliationInfo><Affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nguyen</LastName><ForeName>Huu Mai Khanh</ForeName><Initials>HMK</Initials><AffiliationInfo><Affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nguyen</LastName><ForeName>Minh Tien</ForeName><Initials>MT</Initials><AffiliationInfo><Affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thai</LastName><ForeName>Quang Tung</ForeName><Initials>QT</Initials><AffiliationInfo><Affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vo</LastName><ForeName>Thanh Vu</ForeName><Initials>TV</Initials><AffiliationInfo><Affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ngo</LastName><ForeName>Ngoc Quang Minh</ForeName><Initials>NQM</Initials><AffiliationInfo><Affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dang</LastName><ForeName>Thi Kim Huyen</ForeName><Initials>TKH</Initials><AffiliationInfo><Affiliation>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cao</LastName><ForeName>Ngoc Huong</ForeName><Initials>NH</Initials><AffiliationInfo><Affiliation>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tran</LastName><ForeName>Thu Van</ForeName><Initials>TV</Initials><AffiliationInfo><Affiliation>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ho</LastName><ForeName>Lu Viet</ForeName><Initials>LV</Initials><AffiliationInfo><Affiliation>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>De Meulder</LastName><ForeName>Bertrand</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>European Institute for Systems Biology and Medicine, 50 avenue Tony Garnier, 69007 Lyon - France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Auffray</LastName><ForeName>Charles</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>European Institute for Systems Biology and Medicine, 50 avenue Tony Garnier, 69007 Lyon - France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hofstra</LastName><ForeName>Jorrit-Jan</ForeName><Initials>JJ</Initials><AffiliationInfo><Affiliation>Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Farrar</LastName><ForeName>Jeremy</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bryant</LastName><ForeName>Juliet E</ForeName><Initials>JE</Initials><AffiliationInfo><Affiliation>Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Jong</LastName><ForeName>Menno</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hibberd</LastName><ForeName>Martin L</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>Genome Institute of Singapore, #02-01, Genome Building, 60 Biopolis Street, Singapore 138672.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>London School of Hygiene & Tropical Medicine, Keppel Street London WC1E 7HT, UK.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>09</Month><Day>27</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Infect Dis</MedlineTA><NlmUniqueID>0413675</NlmUniqueID><ISSNLinking>0022-1899</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Respiratory syncytial virus</Keyword><Keyword MajorTopicYN="N">children under 2 years old</Keyword><Keyword MajorTopicYN="N">host expression profile</Keyword><Keyword MajorTopicYN="N">lower respiratory tract infections</Keyword><Keyword MajorTopicYN="N">rhinovirus</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>05</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>10</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>10</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>10</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29029245</ArticleId><ArticleId IdType="pii">4265606</ArticleId><ArticleId IdType="doi">10.1093/infdis/jix519</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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