Visit-to-visit variability of blood pressure and cardiovascular outcomes in patients with stable coronary heart disease. Insights from the STABILITY trial.
Identifieur interne : 000435 ( PubMed/Corpus ); précédent : 000434; suivant : 000436Visit-to-visit variability of blood pressure and cardiovascular outcomes in patients with stable coronary heart disease. Insights from the STABILITY trial.
Auteurs : Emmanuelle Vidal-Petiot ; Amanda Stebbins ; Karen Chiswell ; Diego Ardissino ; Philip E. Aylward ; Christopher P. Cannon ; Marco A. Ramos Corrales ; Claes Held ; José Luis L Pez-Send N ; Ralph A H. Stewart ; Lars Wallentin ; Harvey D. White ; Philippe Gabriel StegSource :
- European heart journal [ 1522-9645 ] ; 2017.
Abstract
To study the relation between visit-to-visit variability of blood pressure (BP) and cardiovascular risk in patients with stable coronary heart disease.
DOI: 10.1093/eurheartj/ehx250
PubMed: 28575274
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Insights from the STABILITY trial.</title><author><name sortKey="Vidal Petiot, Emmanuelle" sort="Vidal Petiot, Emmanuelle" uniqKey="Vidal Petiot E" first="Emmanuelle" last="Vidal-Petiot">Emmanuelle Vidal-Petiot</name><affiliation><nlm:affiliation>Cardiology and Physiology Departments, Département Hospitalo-Universitaire FIRE, AP-HP, Hôpital Bichat, 46 rue Henri Huchard, 75018 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Stebbins, Amanda" sort="Stebbins, Amanda" uniqKey="Stebbins A" first="Amanda" last="Stebbins">Amanda Stebbins</name><affiliation><nlm:affiliation>Duke Clinical Research Institute, Duke University Medical Center, 2400 Pratt Street, Durham, NC 27705, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Chiswell, Karen" sort="Chiswell, Karen" uniqKey="Chiswell K" first="Karen" last="Chiswell">Karen Chiswell</name><affiliation><nlm:affiliation>Duke Clinical Research Institute, Duke University Medical Center, 2400 Pratt Street, Durham, NC 27705, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ardissino, Diego" sort="Ardissino, Diego" uniqKey="Ardissino D" first="Diego" last="Ardissino">Diego Ardissino</name><affiliation><nlm:affiliation>Azienda Ospedaliero, Universitaria di Parma, Via Gramsci 14, 43126 Parma, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Aylward, Philip E" sort="Aylward, Philip E" uniqKey="Aylward P" first="Philip E" last="Aylward">Philip E. Aylward</name><affiliation><nlm:affiliation>South Australian Health and Medical Research Institute, Flinders University and Medical Centre, Adelaide, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Cannon, Christopher P" sort="Cannon, Christopher P" uniqKey="Cannon C" first="Christopher P" last="Cannon">Christopher P. Cannon</name><affiliation><nlm:affiliation>Cardiovascular Division, Brigham and Women's Hospital, 70 Francis street, Boston, MA 02115, USA and former employee at Harvard Clinical Research Institute, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ramos Corrales, Marco A" sort="Ramos Corrales, Marco A" uniqKey="Ramos Corrales M" first="Marco A" last="Ramos Corrales">Marco A. Ramos Corrales</name><affiliation><nlm:affiliation>San Jose Satelite Hospital, Naucalpan, Circunvalacion Poniente 53, 53100 Naucalpan de Juárez, Mexico.</nlm:affiliation></affiliation></author><author><name sortKey="Held, Claes" sort="Held, Claes" uniqKey="Held C" first="Claes" last="Held">Claes Held</name><affiliation><nlm:affiliation>Department of Medical Sciences, Cardiology and Uppsala Clinical Research Center, Uppsala University, Dag Hammarskjölds väg 14B, SE-752 37 Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="L Pez Send N, Jose Luis" sort="L Pez Send N, Jose Luis" uniqKey="L Pez Send N J" first="José Luis" last="L Pez-Send N">José Luis L Pez-Send N</name><affiliation><nlm:affiliation>Hospital Universitario La Paz, IdiPaz, Paseo de la Castellana 261, Planta 1, 28046 Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Stewart, Ralph A H" sort="Stewart, Ralph A H" uniqKey="Stewart R" first="Ralph A H" last="Stewart">Ralph A H. Stewart</name><affiliation><nlm:affiliation>Green Lane Cardiovascular Service, Auckland City Hospital, University of Auckland, Private Bag 92024, Auckland 1030, New Zealand.</nlm:affiliation></affiliation></author><author><name sortKey="Wallentin, Lars" sort="Wallentin, Lars" uniqKey="Wallentin L" first="Lars" last="Wallentin">Lars Wallentin</name><affiliation><nlm:affiliation>Department of Medical Sciences, Cardiology and Uppsala Clinical Research Center, Uppsala University, Dag Hammarskjölds väg 14B, SE-752 37 Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="White, Harvey D" sort="White, Harvey D" uniqKey="White H" first="Harvey D" last="White">Harvey D. White</name><affiliation><nlm:affiliation>Green Lane Cardiovascular Service, Auckland City Hospital, University of Auckland, Private Bag 92024, Auckland 1030, New Zealand.</nlm:affiliation></affiliation></author><author><name sortKey="Steg, Philippe Gabriel" sort="Steg, Philippe Gabriel" uniqKey="Steg P" first="Philippe Gabriel" last="Steg">Philippe Gabriel Steg</name><affiliation><nlm:affiliation>Cardiology and Physiology Departments, Département Hospitalo-Universitaire FIRE, AP-HP, Hôpital Bichat, 46 rue Henri Huchard, 75018 Paris, France.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28575274</idno><idno type="pmid">28575274</idno><idno type="doi">10.1093/eurheartj/ehx250</idno><idno type="wicri:Area/PubMed/Corpus">000435</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000435</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Visit-to-visit variability of blood pressure and cardiovascular outcomes in patients with stable coronary heart disease. Insights from the STABILITY trial.</title><author><name sortKey="Vidal Petiot, Emmanuelle" sort="Vidal Petiot, Emmanuelle" uniqKey="Vidal Petiot E" first="Emmanuelle" last="Vidal-Petiot">Emmanuelle Vidal-Petiot</name><affiliation><nlm:affiliation>Cardiology and Physiology Departments, Département Hospitalo-Universitaire FIRE, AP-HP, Hôpital Bichat, 46 rue Henri Huchard, 75018 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Stebbins, Amanda" sort="Stebbins, Amanda" uniqKey="Stebbins A" first="Amanda" last="Stebbins">Amanda Stebbins</name><affiliation><nlm:affiliation>Duke Clinical Research Institute, Duke University Medical Center, 2400 Pratt Street, Durham, NC 27705, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Chiswell, Karen" sort="Chiswell, Karen" uniqKey="Chiswell K" first="Karen" last="Chiswell">Karen Chiswell</name><affiliation><nlm:affiliation>Duke Clinical Research Institute, Duke University Medical Center, 2400 Pratt Street, Durham, NC 27705, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ardissino, Diego" sort="Ardissino, Diego" uniqKey="Ardissino D" first="Diego" last="Ardissino">Diego Ardissino</name><affiliation><nlm:affiliation>Azienda Ospedaliero, Universitaria di Parma, Via Gramsci 14, 43126 Parma, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Aylward, Philip E" sort="Aylward, Philip E" uniqKey="Aylward P" first="Philip E" last="Aylward">Philip E. Aylward</name><affiliation><nlm:affiliation>South Australian Health and Medical Research Institute, Flinders University and Medical Centre, Adelaide, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Cannon, Christopher P" sort="Cannon, Christopher P" uniqKey="Cannon C" first="Christopher P" last="Cannon">Christopher P. Cannon</name><affiliation><nlm:affiliation>Cardiovascular Division, Brigham and Women's Hospital, 70 Francis street, Boston, MA 02115, USA and former employee at Harvard Clinical Research Institute, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ramos Corrales, Marco A" sort="Ramos Corrales, Marco A" uniqKey="Ramos Corrales M" first="Marco A" last="Ramos Corrales">Marco A. Ramos Corrales</name><affiliation><nlm:affiliation>San Jose Satelite Hospital, Naucalpan, Circunvalacion Poniente 53, 53100 Naucalpan de Juárez, Mexico.</nlm:affiliation></affiliation></author><author><name sortKey="Held, Claes" sort="Held, Claes" uniqKey="Held C" first="Claes" last="Held">Claes Held</name><affiliation><nlm:affiliation>Department of Medical Sciences, Cardiology and Uppsala Clinical Research Center, Uppsala University, Dag Hammarskjölds väg 14B, SE-752 37 Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="L Pez Send N, Jose Luis" sort="L Pez Send N, Jose Luis" uniqKey="L Pez Send N J" first="José Luis" last="L Pez-Send N">José Luis L Pez-Send N</name><affiliation><nlm:affiliation>Hospital Universitario La Paz, IdiPaz, Paseo de la Castellana 261, Planta 1, 28046 Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Stewart, Ralph A H" sort="Stewart, Ralph A H" uniqKey="Stewart R" first="Ralph A H" last="Stewart">Ralph A H. Stewart</name><affiliation><nlm:affiliation>Green Lane Cardiovascular Service, Auckland City Hospital, University of Auckland, Private Bag 92024, Auckland 1030, New Zealand.</nlm:affiliation></affiliation></author><author><name sortKey="Wallentin, Lars" sort="Wallentin, Lars" uniqKey="Wallentin L" first="Lars" last="Wallentin">Lars Wallentin</name><affiliation><nlm:affiliation>Department of Medical Sciences, Cardiology and Uppsala Clinical Research Center, Uppsala University, Dag Hammarskjölds väg 14B, SE-752 37 Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="White, Harvey D" sort="White, Harvey D" uniqKey="White H" first="Harvey D" last="White">Harvey D. White</name><affiliation><nlm:affiliation>Green Lane Cardiovascular Service, Auckland City Hospital, University of Auckland, Private Bag 92024, Auckland 1030, New Zealand.</nlm:affiliation></affiliation></author><author><name sortKey="Steg, Philippe Gabriel" sort="Steg, Philippe Gabriel" uniqKey="Steg P" first="Philippe Gabriel" last="Steg">Philippe Gabriel Steg</name><affiliation><nlm:affiliation>Cardiology and Physiology Departments, Département Hospitalo-Universitaire FIRE, AP-HP, Hôpital Bichat, 46 rue Henri Huchard, 75018 Paris, France.</nlm:affiliation></affiliation></author></analytic><series><title level="j">European heart journal</title><idno type="eISSN">1522-9645</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To study the relation between visit-to-visit variability of blood pressure (BP) and cardiovascular risk in patients with stable coronary heart disease.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28575274</PMID><DateCreated><Year>2017</Year><Month>06</Month><Day>02</Day></DateCreated><DateRevised><Year>2017</Year><Month>10</Month><Day>06</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1522-9645</ISSN><JournalIssue CitedMedium="Internet"><Volume>38</Volume><Issue>37</Issue><PubDate><Year>2017</Year><Month>Oct</Month><Day>01</Day></PubDate></JournalIssue><Title>European heart journal</Title><ISOAbbreviation>Eur. Heart J.</ISOAbbreviation></Journal><ArticleTitle>Visit-to-visit variability of blood pressure and cardiovascular outcomes in patients with stable coronary heart disease. Insights from the STABILITY trial.</ArticleTitle><Pagination><MedlinePgn>2813-2822</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/eurheartj/ehx250</ELocationID><Abstract><AbstractText Label="Aims" NlmCategory="UNASSIGNED">To study the relation between visit-to-visit variability of blood pressure (BP) and cardiovascular risk in patients with stable coronary heart disease.</AbstractText><AbstractText Label="Methods and results" NlmCategory="UNASSIGNED">In 15 828 patients from the STABILITY trial (darapladib vs. placebo in patients with established coronary heart disease), BP variability was assessed by the standard deviation (SD) of systolic BP, the SD of diastolic BP, maximum BP, and minimum BP, from 5 measurements (baseline and months 1, 3, 6, and 12) during the first year after randomisation. Mean (SD) average BP during the first year of study was 131.0 (13.7) mmHg over 78.3 (8.3) mmHg. Mean (SD) of the visit-to-visit SD was 9.8 (4.8) mmHg for systolic and 6.3 (3.0) mmHg for diastolic BP. During the subsequent median follow-up of 2.6 years, 1010 patients met the primary endpoint, a composite of time to cardiovascular death, myocardial infarction, or stroke. In Cox regression models adjusted for average BP during first year of study, baseline vascular disease, treatment, renal function and cardiovascular risk factors, the primary endpoint was associated with SD of systolic BP (hazard ratio for highest vs. lowest tertile, 1.30, 95% CI 1.10-1.53, P = 0.007), and with SD of diastolic BP (hazard ratio for highest vs. lowest tertile, 1.38, 95% CI 1.18-1.62, P < 0.001). Peaks and troughs in BP were also independently associated with adverse events.</AbstractText><AbstractText Label="Conclusion" NlmCategory="UNASSIGNED">In patients with stable coronary heart disease, higher visit-to-visit variabilities of both systolic and diastolic BP are strong predictors of increased risk of cardiovascular events, independently of mean BP.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Vidal-Petiot</LastName><ForeName>Emmanuelle</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Cardiology and Physiology Departments, Département Hospitalo-Universitaire FIRE, AP-HP, Hôpital Bichat, 46 rue Henri Huchard, 75018 Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Paris Diderot University, Sorbonne Paris Cité, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INSERM U1149, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stebbins</LastName><ForeName>Amanda</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Duke Clinical Research Institute, Duke University Medical Center, 2400 Pratt Street, Durham, NC 27705, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chiswell</LastName><ForeName>Karen</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Duke Clinical Research Institute, Duke University Medical Center, 2400 Pratt Street, Durham, NC 27705, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ardissino</LastName><ForeName>Diego</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Azienda Ospedaliero, Universitaria di Parma, Via Gramsci 14, 43126 Parma, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aylward</LastName><ForeName>Philip E</ForeName><Initials>PE</Initials><AffiliationInfo><Affiliation>South Australian Health and Medical Research Institute, Flinders University and Medical Centre, Adelaide, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cannon</LastName><ForeName>Christopher P</ForeName><Initials>CP</Initials><AffiliationInfo><Affiliation>Cardiovascular Division, Brigham and Women's Hospital, 70 Francis street, Boston, MA 02115, USA and former employee at Harvard Clinical Research Institute, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ramos Corrales</LastName><ForeName>Marco A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>San Jose Satelite Hospital, Naucalpan, Circunvalacion Poniente 53, 53100 Naucalpan de Juárez, Mexico.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Held</LastName><ForeName>Claes</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Medical Sciences, Cardiology and Uppsala Clinical Research Center, Uppsala University, Dag Hammarskjölds väg 14B, SE-752 37 Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>López-Sendón</LastName><ForeName>José Luis</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Hospital Universitario La Paz, IdiPaz, Paseo de la Castellana 261, Planta 1, 28046 Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stewart</LastName><ForeName>Ralph A H</ForeName><Initials>RAH</Initials><AffiliationInfo><Affiliation>Green Lane Cardiovascular Service, Auckland City Hospital, University of Auckland, Private Bag 92024, Auckland 1030, New Zealand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wallentin</LastName><ForeName>Lars</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Medical Sciences, Cardiology and Uppsala Clinical Research Center, Uppsala University, Dag Hammarskjölds väg 14B, SE-752 37 Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>White</LastName><ForeName>Harvey D</ForeName><Initials>HD</Initials><AffiliationInfo><Affiliation>Green Lane Cardiovascular Service, Auckland City Hospital, University of Auckland, Private Bag 92024, Auckland 1030, New Zealand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Steg</LastName><ForeName>Philippe Gabriel</ForeName><Initials>PG</Initials><AffiliationInfo><Affiliation>Cardiology and Physiology Departments, Département Hospitalo-Universitaire FIRE, AP-HP, Hôpital Bichat, 46 rue Henri Huchard, 75018 Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Paris Diderot University, Sorbonne Paris Cité, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>NHLI Imperial College, ICMS, Royal Brompton Hospital, London, UK, FACT (French Alliance for Cardiovascular Trials), F-CRIN network, INSERM U1148, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>STABILITY Investigators</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Eur Heart J</MedlineTA><NlmUniqueID>8006263</NlmUniqueID><ISSNLinking>0195-668X</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Coronary heart disease</Keyword><Keyword MajorTopicYN="N">STABILITY trial</Keyword><Keyword MajorTopicYN="N">Visit-to-visit variability of blood pressure</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>12</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>04</Month><Day>20</Day></PubMedPubDate><PubMedPubDate 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