Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma.
Identifieur interne : 000398 ( PubMed/Corpus ); précédent : 000397; suivant : 000399Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma.
Auteurs : Alan Mackay ; Anna Burford ; Diana Carvalho ; Elisa Izquierdo ; Janat Fazal-Salom ; Kathryn R. Taylor ; Lynn Bjerke ; Matthew Clarke ; Mara Vinci ; Meera Nandhabalan ; Sara Temelso ; Sergey Popov ; Valeria Molinari ; Pichai Raman ; Angela J. Waanders ; Harry J. Han ; Saumya Gupta ; Lynley Marshall ; Stergios Zacharoulis ; Sucheta Vaidya ; Henry C. Mandeville ; Leslie R. Bridges ; Andrew J. Martin ; Safa Al-Sarraj ; Christopher Chandler ; Ho-Keung Ng ; Xingang Li ; Kun Mu ; Saoussen Trabelsi ; Dorra H'Mida-Ben Brahim ; Alexei N. Kisljakov ; Dmitry M. Konovalov ; Andrew S. Moore ; Angel Montero Carcaboso ; Mariona Sunol ; Carmen De Torres ; Ofelia Cruz ; Jaume Mora ; Ludmila I. Shats ; João N. Stavale ; Lucas T. Bidinotto ; Rui M. Reis ; Natacha Entz-Werle ; Michael Farrell ; Jane Cryan ; Darach Crimmins ; John Caird ; Jane Pears ; Michelle Monje ; Marie-Anne Debily ; David Castel ; Jacques Grill ; Cynthia Hawkins ; Hamid Nikbakht ; Nada Jabado ; Suzanne J. Baker ; Stefan M. Pfister ; David T W. Jones ; Maryam Fouladi ; André O. Von Bueren ; Michael Baudis ; Adam Resnick ; Chris JonesSource :
- Cancer cell [ 1878-3686 ] ; 2017.
English descriptors
- KwdEn :
- Adolescent, Brain Stem Neoplasms (genetics), Brain Stem Neoplasms (pathology), Cell Cycle Proteins (genetics), Child, Child, Preschool, DNA Topoisomerases, Type I (genetics), Exome, F-Box Proteins (genetics), Female, Gene Dosage, Glioma (genetics), Glioma (pathology), Histones (genetics), Humans, Infant, Infant, Newborn, Male, Mutation, Proto-Oncogene Proteins (genetics), Repressor Proteins (genetics), Ubiquitin-Protein Ligases (genetics), Young Adult.
- MESH :
- chemical , genetics : Cell Cycle Proteins, DNA Topoisomerases, Type I, F-Box Proteins, Histones, Proto-Oncogene Proteins, Repressor Proteins, Ubiquitin-Protein Ligases.
- genetics : Brain Stem Neoplasms, Glioma.
- pathology : Brain Stem Neoplasms, Glioma.
- Adolescent, Child, Child, Preschool, Exome, Female, Gene Dosage, Humans, Infant, Infant, Newborn, Male, Mutation, Young Adult.
Abstract
We collated data from 157 unpublished cases of pediatric high-grade glioma and diffuse intrinsic pontine glioma and 20 publicly available datasets in an integrated analysis of >1,000 cases. We identified co-segregating mutations in histone-mutant subgroups including loss of FBXW7 in H3.3G34R/V, TOP3A rearrangements in H3.3K27M, and BCOR mutations in H3.1K27M. Histone wild-type subgroups are refined by the presence of key oncogenic events or methylation profiles more closely resembling lower-grade tumors. Genomic aberrations increase with age, highlighting the infant population as biologically and clinically distinct. Uncommon pathway dysregulation is seen in small subsets of tumors, further defining the molecular diversity of the disease, opening up avenues for biological study and providing a basis for functionally defined future treatment stratification.
DOI: 10.1016/j.ccell.2017.08.017
PubMed: 28966033
Links to Exploration step
pubmed:28966033Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma.</title><author><name sortKey="Mackay, Alan" sort="Mackay, Alan" uniqKey="Mackay A" first="Alan" last="Mackay">Alan Mackay</name><affiliation><nlm:affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Burford, Anna" sort="Burford, Anna" uniqKey="Burford A" first="Anna" last="Burford">Anna Burford</name><affiliation><nlm:affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Carvalho, Diana" sort="Carvalho, Diana" uniqKey="Carvalho D" first="Diana" last="Carvalho">Diana Carvalho</name><affiliation><nlm:affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Izquierdo, Elisa" sort="Izquierdo, Elisa" uniqKey="Izquierdo E" first="Elisa" last="Izquierdo">Elisa Izquierdo</name><affiliation><nlm:affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Fazal Salom, Janat" sort="Fazal Salom, Janat" uniqKey="Fazal Salom J" first="Janat" last="Fazal-Salom">Janat Fazal-Salom</name><affiliation><nlm:affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Taylor, Kathryn R" sort="Taylor, Kathryn R" uniqKey="Taylor K" first="Kathryn R" last="Taylor">Kathryn R. Taylor</name><affiliation><nlm:affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK; Department of Neurology, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bjerke, Lynn" sort="Bjerke, Lynn" uniqKey="Bjerke L" first="Lynn" last="Bjerke">Lynn Bjerke</name><affiliation><nlm:affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Clarke, Matthew" sort="Clarke, Matthew" uniqKey="Clarke M" first="Matthew" last="Clarke">Matthew Clarke</name><affiliation><nlm:affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Vinci, Mara" sort="Vinci, Mara" uniqKey="Vinci M" first="Mara" last="Vinci">Mara Vinci</name><affiliation><nlm:affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Nandhabalan, Meera" sort="Nandhabalan, Meera" uniqKey="Nandhabalan M" first="Meera" last="Nandhabalan">Meera Nandhabalan</name><affiliation><nlm:affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Temelso, Sara" sort="Temelso, Sara" uniqKey="Temelso S" first="Sara" last="Temelso">Sara Temelso</name><affiliation><nlm:affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Popov, Sergey" sort="Popov, Sergey" uniqKey="Popov S" first="Sergey" last="Popov">Sergey Popov</name><affiliation><nlm:affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK; Department of Cellular Pathology, University Hospital of Wales, Cardiff, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Molinari, Valeria" sort="Molinari, Valeria" uniqKey="Molinari V" first="Valeria" last="Molinari">Valeria Molinari</name><affiliation><nlm:affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Raman, Pichai" sort="Raman, Pichai" uniqKey="Raman P" first="Pichai" last="Raman">Pichai Raman</name><affiliation><nlm:affiliation>The Center for Data Driven Discovery in Biomedicine (D(3)b), Children's Hospital of Philadelphia, Philadelphia, PA, USA; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Waanders, Angela J" sort="Waanders, Angela J" uniqKey="Waanders A" first="Angela J" last="Waanders">Angela J. Waanders</name><affiliation><nlm:affiliation>The Center for Data Driven Discovery in Biomedicine (D(3)b), Children's Hospital of Philadelphia, Philadelphia, PA, USA; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Han, Harry J" sort="Han, Harry J" uniqKey="Han H" first="Harry J" last="Han">Harry J. Han</name><affiliation><nlm:affiliation>The Center for Data Driven Discovery in Biomedicine (D(3)b), Children's Hospital of Philadelphia, Philadelphia, PA, USA; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Gupta, Saumya" sort="Gupta, Saumya" uniqKey="Gupta S" first="Saumya" last="Gupta">Saumya Gupta</name><affiliation><nlm:affiliation>Institute of Molecular Life Sciences, Swiss Institute of Bioinformatics, University of Zürich, Zürich, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Marshall, Lynley" sort="Marshall, Lynley" uniqKey="Marshall L" first="Lynley" last="Marshall">Lynley Marshall</name><affiliation><nlm:affiliation>Pediatric Oncology Drug Development Team, Children and Young People's Unit, Royal Marsden Hospital, Sutton, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Zacharoulis, Stergios" sort="Zacharoulis, Stergios" uniqKey="Zacharoulis S" first="Stergios" last="Zacharoulis">Stergios Zacharoulis</name><affiliation><nlm:affiliation>Pediatric Oncology Drug Development Team, Children and Young People's Unit, Royal Marsden Hospital, Sutton, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Vaidya, Sucheta" sort="Vaidya, Sucheta" uniqKey="Vaidya S" first="Sucheta" last="Vaidya">Sucheta Vaidya</name><affiliation><nlm:affiliation>Pediatric Oncology Drug Development Team, Children and Young People's Unit, Royal Marsden Hospital, Sutton, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Mandeville, Henry C" sort="Mandeville, Henry C" uniqKey="Mandeville H" first="Henry C" last="Mandeville">Henry C. Mandeville</name><affiliation><nlm:affiliation>Department of Radiotherapy, Royal Marsden Hospital, Sutton, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Bridges, Leslie R" sort="Bridges, Leslie R" uniqKey="Bridges L" first="Leslie R" last="Bridges">Leslie R. Bridges</name><affiliation><nlm:affiliation>Department of Cellular Pathology, St George's Hospital NHS Trust, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Martin, Andrew J" sort="Martin, Andrew J" uniqKey="Martin A" first="Andrew J" last="Martin">Andrew J. Martin</name><affiliation><nlm:affiliation>Department of Neurosurgery, St George's Hospital NHS Trust, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Al Sarraj, Safa" sort="Al Sarraj, Safa" uniqKey="Al Sarraj S" first="Safa" last="Al-Sarraj">Safa Al-Sarraj</name><affiliation><nlm:affiliation>Department of Neuropathology, Kings College Hospital, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Chandler, Christopher" sort="Chandler, Christopher" uniqKey="Chandler C" first="Christopher" last="Chandler">Christopher Chandler</name><affiliation><nlm:affiliation>Department of Neurosurgery, Kings College Hospital, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Ng, Ho Keung" sort="Ng, Ho Keung" uniqKey="Ng H" first="Ho-Keung" last="Ng">Ho-Keung Ng</name><affiliation><nlm:affiliation>Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Xingang" sort="Li, Xingang" uniqKey="Li X" first="Xingang" last="Li">Xingang Li</name><affiliation><nlm:affiliation>Department of Neurosurgery, Qilu Hospital of Shandong University and Brain Science Research Institute, Shandong University, Jinan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Mu, Kun" sort="Mu, Kun" uniqKey="Mu K" first="Kun" last="Mu">Kun Mu</name><affiliation><nlm:affiliation>Department of Pathology, Shandong University School of Medicine, Jinan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Trabelsi, Saoussen" sort="Trabelsi, Saoussen" uniqKey="Trabelsi S" first="Saoussen" last="Trabelsi">Saoussen Trabelsi</name><affiliation><nlm:affiliation>Department of Cytogenetics and Reproductive Biology, Farhat Hached Hospital, Sousse, Tunisia.</nlm:affiliation></affiliation></author><author><name sortKey="Brahim, Dorra H Mida Ben" sort="Brahim, Dorra H Mida Ben" uniqKey="Brahim D" first="Dorra H'Mida-Ben" last="Brahim">Dorra H'Mida-Ben Brahim</name><affiliation><nlm:affiliation>Department of Cytogenetics and Reproductive Biology, Farhat Hached Hospital, Sousse, Tunisia.</nlm:affiliation></affiliation></author><author><name sortKey="Kisljakov, Alexei N" sort="Kisljakov, Alexei N" uniqKey="Kisljakov A" first="Alexei N" last="Kisljakov">Alexei N. Kisljakov</name><affiliation><nlm:affiliation>Department of Pathology, Morozov Children's Hospital, Moscow, Russian Federation.</nlm:affiliation></affiliation></author><author><name sortKey="Konovalov, Dmitry M" sort="Konovalov, Dmitry M" uniqKey="Konovalov D" first="Dmitry M" last="Konovalov">Dmitry M. Konovalov</name><affiliation><nlm:affiliation>Department of Pathology, Dmitrii Rogachev Research and Clinical Centre of Pediatric Hematology, Oncology and Immunology, Moscow, Russian Federation.</nlm:affiliation></affiliation></author><author><name sortKey="Moore, Andrew S" sort="Moore, Andrew S" uniqKey="Moore A" first="Andrew S" last="Moore">Andrew S. Moore</name><affiliation><nlm:affiliation>UQ Child Health Research Centre, The University of Queensland, Brisbane, Australia; Oncology Services Group, Children's Health Queensland Hospital and Health Service, Brisbane, Australia; The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Carcaboso, Angel Montero" sort="Carcaboso, Angel Montero" uniqKey="Carcaboso A" first="Angel Montero" last="Carcaboso">Angel Montero Carcaboso</name><affiliation><nlm:affiliation>Institut de Recerca Sant Joan de Deu, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Sunol, Mariona" sort="Sunol, Mariona" uniqKey="Sunol M" first="Mariona" last="Sunol">Mariona Sunol</name><affiliation><nlm:affiliation>Institut de Recerca Sant Joan de Deu, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="De Torres, Carmen" sort="De Torres, Carmen" uniqKey="De Torres C" first="Carmen" last="De Torres">Carmen De Torres</name><affiliation><nlm:affiliation>Institut de Recerca Sant Joan de Deu, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Cruz, Ofelia" sort="Cruz, Ofelia" uniqKey="Cruz O" first="Ofelia" last="Cruz">Ofelia Cruz</name><affiliation><nlm:affiliation>Institut de Recerca Sant Joan de Deu, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Mora, Jaume" sort="Mora, Jaume" uniqKey="Mora J" first="Jaume" last="Mora">Jaume Mora</name><affiliation><nlm:affiliation>Institut de Recerca Sant Joan de Deu, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Shats, Ludmila I" sort="Shats, Ludmila I" uniqKey="Shats L" first="Ludmila I" last="Shats">Ludmila I. Shats</name><affiliation><nlm:affiliation>Division of Oncology, Pediatric Oncology and Radiotherapy, St Petersburg State Pediatric Medical University, St Petersburg, Russian Federation.</nlm:affiliation></affiliation></author><author><name sortKey="Stavale, Joao N" sort="Stavale, Joao N" uniqKey="Stavale J" first="João N" last="Stavale">João N. Stavale</name><affiliation><nlm:affiliation>Department of Pathology, Federal University of São Paulo, São Paulo, São Paulo, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Bidinotto, Lucas T" sort="Bidinotto, Lucas T" uniqKey="Bidinotto L" first="Lucas T" last="Bidinotto">Lucas T. Bidinotto</name><affiliation><nlm:affiliation>Molecular Oncology Research Centre, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Reis, Rui M" sort="Reis, Rui M" uniqKey="Reis R" first="Rui M" last="Reis">Rui M. Reis</name><affiliation><nlm:affiliation>Molecular Oncology Research Centre, Barretos Cancer Hospital, Barretos, São Paulo, Brazil; Life and Health Sciences Research Institute (ICVS), Medical School, University of Minho, Braga, Portugal and ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal.</nlm:affiliation></affiliation></author><author><name sortKey="Entz Werle, Natacha" sort="Entz Werle, Natacha" uniqKey="Entz Werle N" first="Natacha" last="Entz-Werle">Natacha Entz-Werle</name><affiliation><nlm:affiliation>Pédiatrie Onco-Hématologie - Pédiatrie III, Centre Hospitalier Régional et Universitaire Hautepierre, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Farrell, Michael" sort="Farrell, Michael" uniqKey="Farrell M" first="Michael" last="Farrell">Michael Farrell</name><affiliation><nlm:affiliation>Histopathology Department, Beaumont Hospital, Dublin, Ireland.</nlm:affiliation></affiliation></author><author><name sortKey="Cryan, Jane" sort="Cryan, Jane" uniqKey="Cryan J" first="Jane" last="Cryan">Jane Cryan</name><affiliation><nlm:affiliation>Histopathology Department, Beaumont Hospital, Dublin, Ireland.</nlm:affiliation></affiliation></author><author><name sortKey="Crimmins, Darach" sort="Crimmins, Darach" uniqKey="Crimmins D" first="Darach" last="Crimmins">Darach Crimmins</name><affiliation><nlm:affiliation>Department of Neurosurgery, Temple Street Children's University Hospital, Dublin, Ireland.</nlm:affiliation></affiliation></author><author><name sortKey="Caird, John" sort="Caird, John" uniqKey="Caird J" first="John" last="Caird">John Caird</name><affiliation><nlm:affiliation>Department of Neurosurgery, Temple Street Children's University Hospital, Dublin, Ireland.</nlm:affiliation></affiliation></author><author><name sortKey="Pears, Jane" sort="Pears, Jane" uniqKey="Pears J" first="Jane" last="Pears">Jane Pears</name><affiliation><nlm:affiliation>Department of Paediatric Oncology, Our Lady's Children's Hospital, Dublin, Ireland.</nlm:affiliation></affiliation></author><author><name sortKey="Monje, Michelle" sort="Monje, Michelle" uniqKey="Monje M" first="Michelle" last="Monje">Michelle Monje</name><affiliation><nlm:affiliation>Department of Neurology, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Debily, Marie Anne" sort="Debily, Marie Anne" uniqKey="Debily M" first="Marie-Anne" last="Debily">Marie-Anne Debily</name><affiliation><nlm:affiliation>Département de Cancerologie de l'Enfant et de l'Adolescent, Institut Gustav Roussy, Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Castel, David" sort="Castel, David" uniqKey="Castel D" first="David" last="Castel">David Castel</name><affiliation><nlm:affiliation>Département de Cancerologie de l'Enfant et de l'Adolescent, Institut Gustav Roussy, Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Grill, Jacques" sort="Grill, Jacques" uniqKey="Grill J" first="Jacques" last="Grill">Jacques Grill</name><affiliation><nlm:affiliation>Département de Cancerologie de l'Enfant et de l'Adolescent, Institut Gustav Roussy, Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Hawkins, Cynthia" sort="Hawkins, Cynthia" uniqKey="Hawkins C" first="Cynthia" last="Hawkins">Cynthia Hawkins</name><affiliation><nlm:affiliation>Pediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Nikbakht, Hamid" sort="Nikbakht, Hamid" uniqKey="Nikbakht H" first="Hamid" last="Nikbakht">Hamid Nikbakht</name><affiliation><nlm:affiliation>Department of Pediatrics, McGill University, Montreal, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Jabado, Nada" sort="Jabado, Nada" uniqKey="Jabado N" first="Nada" last="Jabado">Nada Jabado</name><affiliation><nlm:affiliation>The Center for Data Driven Discovery in Biomedicine (D(3)b), Children's Hospital of Philadelphia, Philadelphia, PA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Baker, Suzanne J" sort="Baker, Suzanne J" uniqKey="Baker S" first="Suzanne J" last="Baker">Suzanne J. Baker</name><affiliation><nlm:affiliation>Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Pfister, Stefan M" sort="Pfister, Stefan M" uniqKey="Pfister S" first="Stefan M" last="Pfister">Stefan M. Pfister</name><affiliation><nlm:affiliation>Division of Pediatric Neuro-oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany; Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Jones, David T W" sort="Jones, David T W" uniqKey="Jones D" first="David T W" last="Jones">David T W. Jones</name><affiliation><nlm:affiliation>Division of Pediatric Neuro-oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Fouladi, Maryam" sort="Fouladi, Maryam" uniqKey="Fouladi M" first="Maryam" last="Fouladi">Maryam Fouladi</name><affiliation><nlm:affiliation>Department of Pediatrics, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital, Cincinnati, OH, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Von Bueren, Andre O" sort="Von Bueren, Andre O" uniqKey="Von Bueren A" first="André O" last="Von Bueren">André O. Von Bueren</name><affiliation><nlm:affiliation>Department of Pediatrics, Division of Pediatric Hematology and Oncology, University Medical Center Goettingen, Goettingen, Germany; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, University Hospital of Geneva, Geneva, Switzerland; Department of Pediatrics, CANSEARCH Research Laboratory, Faculty of Medicine, University of Geneva, Geneva, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Baudis, Michael" sort="Baudis, Michael" uniqKey="Baudis M" first="Michael" last="Baudis">Michael Baudis</name><affiliation><nlm:affiliation>Institute of Molecular Life Sciences, Swiss Institute of Bioinformatics, University of Zürich, Zürich, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Resnick, Adam" sort="Resnick, Adam" uniqKey="Resnick A" first="Adam" last="Resnick">Adam Resnick</name><affiliation><nlm:affiliation>The Center for Data Driven Discovery in Biomedicine (D(3)b), Children's Hospital of Philadelphia, Philadelphia, PA, USA; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Jones, Chris" sort="Jones, Chris" uniqKey="Jones C" first="Chris" last="Jones">Chris Jones</name><affiliation><nlm:affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK. Electronic address: chris.jones@icr.ac.uk.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28966033</idno><idno type="pmid">28966033</idno><idno type="doi">10.1016/j.ccell.2017.08.017</idno><idno type="wicri:Area/PubMed/Corpus">000398</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000398</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma.</title><author><name sortKey="Mackay, Alan" sort="Mackay, Alan" uniqKey="Mackay A" first="Alan" last="Mackay">Alan Mackay</name><affiliation><nlm:affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Burford, Anna" sort="Burford, Anna" uniqKey="Burford A" first="Anna" last="Burford">Anna Burford</name><affiliation><nlm:affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Carvalho, Diana" sort="Carvalho, Diana" uniqKey="Carvalho D" first="Diana" last="Carvalho">Diana Carvalho</name><affiliation><nlm:affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Izquierdo, Elisa" sort="Izquierdo, Elisa" uniqKey="Izquierdo E" first="Elisa" last="Izquierdo">Elisa Izquierdo</name><affiliation><nlm:affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Fazal Salom, Janat" sort="Fazal Salom, Janat" uniqKey="Fazal Salom J" first="Janat" last="Fazal-Salom">Janat Fazal-Salom</name><affiliation><nlm:affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Taylor, Kathryn R" sort="Taylor, Kathryn R" uniqKey="Taylor K" first="Kathryn R" last="Taylor">Kathryn R. Taylor</name><affiliation><nlm:affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK; Department of Neurology, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bjerke, Lynn" sort="Bjerke, Lynn" uniqKey="Bjerke L" first="Lynn" last="Bjerke">Lynn Bjerke</name><affiliation><nlm:affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Clarke, Matthew" sort="Clarke, Matthew" uniqKey="Clarke M" first="Matthew" last="Clarke">Matthew Clarke</name><affiliation><nlm:affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Vinci, Mara" sort="Vinci, Mara" uniqKey="Vinci M" first="Mara" last="Vinci">Mara Vinci</name><affiliation><nlm:affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Nandhabalan, Meera" sort="Nandhabalan, Meera" uniqKey="Nandhabalan M" first="Meera" last="Nandhabalan">Meera Nandhabalan</name><affiliation><nlm:affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Temelso, Sara" sort="Temelso, Sara" uniqKey="Temelso S" first="Sara" last="Temelso">Sara Temelso</name><affiliation><nlm:affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Popov, Sergey" sort="Popov, Sergey" uniqKey="Popov S" first="Sergey" last="Popov">Sergey Popov</name><affiliation><nlm:affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK; Department of Cellular Pathology, University Hospital of Wales, Cardiff, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Molinari, Valeria" sort="Molinari, Valeria" uniqKey="Molinari V" first="Valeria" last="Molinari">Valeria Molinari</name><affiliation><nlm:affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Raman, Pichai" sort="Raman, Pichai" uniqKey="Raman P" first="Pichai" last="Raman">Pichai Raman</name><affiliation><nlm:affiliation>The Center for Data Driven Discovery in Biomedicine (D(3)b), Children's Hospital of Philadelphia, Philadelphia, PA, USA; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Waanders, Angela J" sort="Waanders, Angela J" uniqKey="Waanders A" first="Angela J" last="Waanders">Angela J. Waanders</name><affiliation><nlm:affiliation>The Center for Data Driven Discovery in Biomedicine (D(3)b), Children's Hospital of Philadelphia, Philadelphia, PA, USA; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Han, Harry J" sort="Han, Harry J" uniqKey="Han H" first="Harry J" last="Han">Harry J. Han</name><affiliation><nlm:affiliation>The Center for Data Driven Discovery in Biomedicine (D(3)b), Children's Hospital of Philadelphia, Philadelphia, PA, USA; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Gupta, Saumya" sort="Gupta, Saumya" uniqKey="Gupta S" first="Saumya" last="Gupta">Saumya Gupta</name><affiliation><nlm:affiliation>Institute of Molecular Life Sciences, Swiss Institute of Bioinformatics, University of Zürich, Zürich, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Marshall, Lynley" sort="Marshall, Lynley" uniqKey="Marshall L" first="Lynley" last="Marshall">Lynley Marshall</name><affiliation><nlm:affiliation>Pediatric Oncology Drug Development Team, Children and Young People's Unit, Royal Marsden Hospital, Sutton, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Zacharoulis, Stergios" sort="Zacharoulis, Stergios" uniqKey="Zacharoulis S" first="Stergios" last="Zacharoulis">Stergios Zacharoulis</name><affiliation><nlm:affiliation>Pediatric Oncology Drug Development Team, Children and Young People's Unit, Royal Marsden Hospital, Sutton, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Vaidya, Sucheta" sort="Vaidya, Sucheta" uniqKey="Vaidya S" first="Sucheta" last="Vaidya">Sucheta Vaidya</name><affiliation><nlm:affiliation>Pediatric Oncology Drug Development Team, Children and Young People's Unit, Royal Marsden Hospital, Sutton, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Mandeville, Henry C" sort="Mandeville, Henry C" uniqKey="Mandeville H" first="Henry C" last="Mandeville">Henry C. Mandeville</name><affiliation><nlm:affiliation>Department of Radiotherapy, Royal Marsden Hospital, Sutton, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Bridges, Leslie R" sort="Bridges, Leslie R" uniqKey="Bridges L" first="Leslie R" last="Bridges">Leslie R. Bridges</name><affiliation><nlm:affiliation>Department of Cellular Pathology, St George's Hospital NHS Trust, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Martin, Andrew J" sort="Martin, Andrew J" uniqKey="Martin A" first="Andrew J" last="Martin">Andrew J. Martin</name><affiliation><nlm:affiliation>Department of Neurosurgery, St George's Hospital NHS Trust, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Al Sarraj, Safa" sort="Al Sarraj, Safa" uniqKey="Al Sarraj S" first="Safa" last="Al-Sarraj">Safa Al-Sarraj</name><affiliation><nlm:affiliation>Department of Neuropathology, Kings College Hospital, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Chandler, Christopher" sort="Chandler, Christopher" uniqKey="Chandler C" first="Christopher" last="Chandler">Christopher Chandler</name><affiliation><nlm:affiliation>Department of Neurosurgery, Kings College Hospital, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Ng, Ho Keung" sort="Ng, Ho Keung" uniqKey="Ng H" first="Ho-Keung" last="Ng">Ho-Keung Ng</name><affiliation><nlm:affiliation>Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Xingang" sort="Li, Xingang" uniqKey="Li X" first="Xingang" last="Li">Xingang Li</name><affiliation><nlm:affiliation>Department of Neurosurgery, Qilu Hospital of Shandong University and Brain Science Research Institute, Shandong University, Jinan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Mu, Kun" sort="Mu, Kun" uniqKey="Mu K" first="Kun" last="Mu">Kun Mu</name><affiliation><nlm:affiliation>Department of Pathology, Shandong University School of Medicine, Jinan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Trabelsi, Saoussen" sort="Trabelsi, Saoussen" uniqKey="Trabelsi S" first="Saoussen" last="Trabelsi">Saoussen Trabelsi</name><affiliation><nlm:affiliation>Department of Cytogenetics and Reproductive Biology, Farhat Hached Hospital, Sousse, Tunisia.</nlm:affiliation></affiliation></author><author><name sortKey="Brahim, Dorra H Mida Ben" sort="Brahim, Dorra H Mida Ben" uniqKey="Brahim D" first="Dorra H'Mida-Ben" last="Brahim">Dorra H'Mida-Ben Brahim</name><affiliation><nlm:affiliation>Department of Cytogenetics and Reproductive Biology, Farhat Hached Hospital, Sousse, Tunisia.</nlm:affiliation></affiliation></author><author><name sortKey="Kisljakov, Alexei N" sort="Kisljakov, Alexei N" uniqKey="Kisljakov A" first="Alexei N" last="Kisljakov">Alexei N. Kisljakov</name><affiliation><nlm:affiliation>Department of Pathology, Morozov Children's Hospital, Moscow, Russian Federation.</nlm:affiliation></affiliation></author><author><name sortKey="Konovalov, Dmitry M" sort="Konovalov, Dmitry M" uniqKey="Konovalov D" first="Dmitry M" last="Konovalov">Dmitry M. Konovalov</name><affiliation><nlm:affiliation>Department of Pathology, Dmitrii Rogachev Research and Clinical Centre of Pediatric Hematology, Oncology and Immunology, Moscow, Russian Federation.</nlm:affiliation></affiliation></author><author><name sortKey="Moore, Andrew S" sort="Moore, Andrew S" uniqKey="Moore A" first="Andrew S" last="Moore">Andrew S. Moore</name><affiliation><nlm:affiliation>UQ Child Health Research Centre, The University of Queensland, Brisbane, Australia; Oncology Services Group, Children's Health Queensland Hospital and Health Service, Brisbane, Australia; The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Carcaboso, Angel Montero" sort="Carcaboso, Angel Montero" uniqKey="Carcaboso A" first="Angel Montero" last="Carcaboso">Angel Montero Carcaboso</name><affiliation><nlm:affiliation>Institut de Recerca Sant Joan de Deu, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Sunol, Mariona" sort="Sunol, Mariona" uniqKey="Sunol M" first="Mariona" last="Sunol">Mariona Sunol</name><affiliation><nlm:affiliation>Institut de Recerca Sant Joan de Deu, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="De Torres, Carmen" sort="De Torres, Carmen" uniqKey="De Torres C" first="Carmen" last="De Torres">Carmen De Torres</name><affiliation><nlm:affiliation>Institut de Recerca Sant Joan de Deu, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Cruz, Ofelia" sort="Cruz, Ofelia" uniqKey="Cruz O" first="Ofelia" last="Cruz">Ofelia Cruz</name><affiliation><nlm:affiliation>Institut de Recerca Sant Joan de Deu, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Mora, Jaume" sort="Mora, Jaume" uniqKey="Mora J" first="Jaume" last="Mora">Jaume Mora</name><affiliation><nlm:affiliation>Institut de Recerca Sant Joan de Deu, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Shats, Ludmila I" sort="Shats, Ludmila I" uniqKey="Shats L" first="Ludmila I" last="Shats">Ludmila I. Shats</name><affiliation><nlm:affiliation>Division of Oncology, Pediatric Oncology and Radiotherapy, St Petersburg State Pediatric Medical University, St Petersburg, Russian Federation.</nlm:affiliation></affiliation></author><author><name sortKey="Stavale, Joao N" sort="Stavale, Joao N" uniqKey="Stavale J" first="João N" last="Stavale">João N. Stavale</name><affiliation><nlm:affiliation>Department of Pathology, Federal University of São Paulo, São Paulo, São Paulo, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Bidinotto, Lucas T" sort="Bidinotto, Lucas T" uniqKey="Bidinotto L" first="Lucas T" last="Bidinotto">Lucas T. Bidinotto</name><affiliation><nlm:affiliation>Molecular Oncology Research Centre, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Reis, Rui M" sort="Reis, Rui M" uniqKey="Reis R" first="Rui M" last="Reis">Rui M. Reis</name><affiliation><nlm:affiliation>Molecular Oncology Research Centre, Barretos Cancer Hospital, Barretos, São Paulo, Brazil; Life and Health Sciences Research Institute (ICVS), Medical School, University of Minho, Braga, Portugal and ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal.</nlm:affiliation></affiliation></author><author><name sortKey="Entz Werle, Natacha" sort="Entz Werle, Natacha" uniqKey="Entz Werle N" first="Natacha" last="Entz-Werle">Natacha Entz-Werle</name><affiliation><nlm:affiliation>Pédiatrie Onco-Hématologie - Pédiatrie III, Centre Hospitalier Régional et Universitaire Hautepierre, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Farrell, Michael" sort="Farrell, Michael" uniqKey="Farrell M" first="Michael" last="Farrell">Michael Farrell</name><affiliation><nlm:affiliation>Histopathology Department, Beaumont Hospital, Dublin, Ireland.</nlm:affiliation></affiliation></author><author><name sortKey="Cryan, Jane" sort="Cryan, Jane" uniqKey="Cryan J" first="Jane" last="Cryan">Jane Cryan</name><affiliation><nlm:affiliation>Histopathology Department, Beaumont Hospital, Dublin, Ireland.</nlm:affiliation></affiliation></author><author><name sortKey="Crimmins, Darach" sort="Crimmins, Darach" uniqKey="Crimmins D" first="Darach" last="Crimmins">Darach Crimmins</name><affiliation><nlm:affiliation>Department of Neurosurgery, Temple Street Children's University Hospital, Dublin, Ireland.</nlm:affiliation></affiliation></author><author><name sortKey="Caird, John" sort="Caird, John" uniqKey="Caird J" first="John" last="Caird">John Caird</name><affiliation><nlm:affiliation>Department of Neurosurgery, Temple Street Children's University Hospital, Dublin, Ireland.</nlm:affiliation></affiliation></author><author><name sortKey="Pears, Jane" sort="Pears, Jane" uniqKey="Pears J" first="Jane" last="Pears">Jane Pears</name><affiliation><nlm:affiliation>Department of Paediatric Oncology, Our Lady's Children's Hospital, Dublin, Ireland.</nlm:affiliation></affiliation></author><author><name sortKey="Monje, Michelle" sort="Monje, Michelle" uniqKey="Monje M" first="Michelle" last="Monje">Michelle Monje</name><affiliation><nlm:affiliation>Department of Neurology, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Debily, Marie Anne" sort="Debily, Marie Anne" uniqKey="Debily M" first="Marie-Anne" last="Debily">Marie-Anne Debily</name><affiliation><nlm:affiliation>Département de Cancerologie de l'Enfant et de l'Adolescent, Institut Gustav Roussy, Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Castel, David" sort="Castel, David" uniqKey="Castel D" first="David" last="Castel">David Castel</name><affiliation><nlm:affiliation>Département de Cancerologie de l'Enfant et de l'Adolescent, Institut Gustav Roussy, Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Grill, Jacques" sort="Grill, Jacques" uniqKey="Grill J" first="Jacques" last="Grill">Jacques Grill</name><affiliation><nlm:affiliation>Département de Cancerologie de l'Enfant et de l'Adolescent, Institut Gustav Roussy, Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Hawkins, Cynthia" sort="Hawkins, Cynthia" uniqKey="Hawkins C" first="Cynthia" last="Hawkins">Cynthia Hawkins</name><affiliation><nlm:affiliation>Pediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Nikbakht, Hamid" sort="Nikbakht, Hamid" uniqKey="Nikbakht H" first="Hamid" last="Nikbakht">Hamid Nikbakht</name><affiliation><nlm:affiliation>Department of Pediatrics, McGill University, Montreal, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Jabado, Nada" sort="Jabado, Nada" uniqKey="Jabado N" first="Nada" last="Jabado">Nada Jabado</name><affiliation><nlm:affiliation>The Center for Data Driven Discovery in Biomedicine (D(3)b), Children's Hospital of Philadelphia, Philadelphia, PA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Baker, Suzanne J" sort="Baker, Suzanne J" uniqKey="Baker S" first="Suzanne J" last="Baker">Suzanne J. Baker</name><affiliation><nlm:affiliation>Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Pfister, Stefan M" sort="Pfister, Stefan M" uniqKey="Pfister S" first="Stefan M" last="Pfister">Stefan M. Pfister</name><affiliation><nlm:affiliation>Division of Pediatric Neuro-oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany; Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Jones, David T W" sort="Jones, David T W" uniqKey="Jones D" first="David T W" last="Jones">David T W. Jones</name><affiliation><nlm:affiliation>Division of Pediatric Neuro-oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Fouladi, Maryam" sort="Fouladi, Maryam" uniqKey="Fouladi M" first="Maryam" last="Fouladi">Maryam Fouladi</name><affiliation><nlm:affiliation>Department of Pediatrics, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital, Cincinnati, OH, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Von Bueren, Andre O" sort="Von Bueren, Andre O" uniqKey="Von Bueren A" first="André O" last="Von Bueren">André O. Von Bueren</name><affiliation><nlm:affiliation>Department of Pediatrics, Division of Pediatric Hematology and Oncology, University Medical Center Goettingen, Goettingen, Germany; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, University Hospital of Geneva, Geneva, Switzerland; Department of Pediatrics, CANSEARCH Research Laboratory, Faculty of Medicine, University of Geneva, Geneva, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Baudis, Michael" sort="Baudis, Michael" uniqKey="Baudis M" first="Michael" last="Baudis">Michael Baudis</name><affiliation><nlm:affiliation>Institute of Molecular Life Sciences, Swiss Institute of Bioinformatics, University of Zürich, Zürich, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Resnick, Adam" sort="Resnick, Adam" uniqKey="Resnick A" first="Adam" last="Resnick">Adam Resnick</name><affiliation><nlm:affiliation>The Center for Data Driven Discovery in Biomedicine (D(3)b), Children's Hospital of Philadelphia, Philadelphia, PA, USA; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Jones, Chris" sort="Jones, Chris" uniqKey="Jones C" first="Chris" last="Jones">Chris Jones</name><affiliation><nlm:affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK. Electronic address: chris.jones@icr.ac.uk.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Cancer cell</title><idno type="eISSN">1878-3686</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Brain Stem Neoplasms (genetics)</term><term>Brain Stem Neoplasms (pathology)</term><term>Cell Cycle Proteins (genetics)</term><term>Child</term><term>Child, Preschool</term><term>DNA Topoisomerases, Type I (genetics)</term><term>Exome</term><term>F-Box Proteins (genetics)</term><term>Female</term><term>Gene Dosage</term><term>Glioma (genetics)</term><term>Glioma (pathology)</term><term>Histones (genetics)</term><term>Humans</term><term>Infant</term><term>Infant, Newborn</term><term>Male</term><term>Mutation</term><term>Proto-Oncogene Proteins (genetics)</term><term>Repressor Proteins (genetics)</term><term>Ubiquitin-Protein Ligases (genetics)</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cell Cycle Proteins</term><term>DNA Topoisomerases, Type I</term><term>F-Box Proteins</term><term>Histones</term><term>Proto-Oncogene Proteins</term><term>Repressor Proteins</term><term>Ubiquitin-Protein Ligases</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Brain Stem Neoplasms</term><term>Glioma</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain Stem Neoplasms</term><term>Glioma</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Child</term><term>Child, Preschool</term><term>Exome</term><term>Female</term><term>Gene Dosage</term><term>Humans</term><term>Infant</term><term>Infant, Newborn</term><term>Male</term><term>Mutation</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We collated data from 157 unpublished cases of pediatric high-grade glioma and diffuse intrinsic pontine glioma and 20 publicly available datasets in an integrated analysis of >1,000 cases. We identified co-segregating mutations in histone-mutant subgroups including loss of FBXW7 in H3.3G34R/V, TOP3A rearrangements in H3.3K27M, and BCOR mutations in H3.1K27M. Histone wild-type subgroups are refined by the presence of key oncogenic events or methylation profiles more closely resembling lower-grade tumors. Genomic aberrations increase with age, highlighting the infant population as biologically and clinically distinct. Uncommon pathway dysregulation is seen in small subsets of tumors, further defining the molecular diversity of the disease, opening up avenues for biological study and providing a basis for functionally defined future treatment stratification.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28966033</PMID><DateCreated><Year>2017</Year><Month>10</Month><Day>02</Day></DateCreated><DateCompleted><Year>2017</Year><Month>10</Month><Day>31</Day></DateCompleted><DateRevised><Year>2017</Year><Month>11</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1878-3686</ISSN><JournalIssue CitedMedium="Internet"><Volume>32</Volume><Issue>4</Issue><PubDate><Year>2017</Year><Month>Oct</Month><Day>09</Day></PubDate></JournalIssue><Title>Cancer cell</Title><ISOAbbreviation>Cancer Cell</ISOAbbreviation></Journal><ArticleTitle>Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma.</ArticleTitle><Pagination><MedlinePgn>520-537.e5</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1535-6108(17)30362-8</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ccell.2017.08.017</ELocationID><Abstract><AbstractText>We collated data from 157 unpublished cases of pediatric high-grade glioma and diffuse intrinsic pontine glioma and 20 publicly available datasets in an integrated analysis of >1,000 cases. We identified co-segregating mutations in histone-mutant subgroups including loss of FBXW7 in H3.3G34R/V, TOP3A rearrangements in H3.3K27M, and BCOR mutations in H3.1K27M. Histone wild-type subgroups are refined by the presence of key oncogenic events or methylation profiles more closely resembling lower-grade tumors. Genomic aberrations increase with age, highlighting the infant population as biologically and clinically distinct. Uncommon pathway dysregulation is seen in small subsets of tumors, further defining the molecular diversity of the disease, opening up avenues for biological study and providing a basis for functionally defined future treatment stratification.</AbstractText><CopyrightInformation>Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mackay</LastName><ForeName>Alan</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Burford</LastName><ForeName>Anna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carvalho</LastName><ForeName>Diana</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Izquierdo</LastName><ForeName>Elisa</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fazal-Salom</LastName><ForeName>Janat</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Taylor</LastName><ForeName>Kathryn R</ForeName><Initials>KR</Initials><AffiliationInfo><Affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK; Department of Neurology, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bjerke</LastName><ForeName>Lynn</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Clarke</LastName><ForeName>Matthew</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vinci</LastName><ForeName>Mara</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nandhabalan</LastName><ForeName>Meera</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Temelso</LastName><ForeName>Sara</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Popov</LastName><ForeName>Sergey</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK; Department of Cellular Pathology, University Hospital of Wales, Cardiff, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Molinari</LastName><ForeName>Valeria</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Raman</LastName><ForeName>Pichai</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>The Center for Data Driven Discovery in Biomedicine (D(3)b), Children's Hospital of Philadelphia, Philadelphia, PA, USA; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Waanders</LastName><ForeName>Angela J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>The Center for Data Driven Discovery in Biomedicine (D(3)b), Children's Hospital of Philadelphia, Philadelphia, PA, USA; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Han</LastName><ForeName>Harry J</ForeName><Initials>HJ</Initials><AffiliationInfo><Affiliation>The Center for Data Driven Discovery in Biomedicine (D(3)b), Children's Hospital of Philadelphia, Philadelphia, PA, USA; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gupta</LastName><ForeName>Saumya</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute of Molecular Life Sciences, Swiss Institute of Bioinformatics, University of Zürich, Zürich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marshall</LastName><ForeName>Lynley</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Pediatric Oncology Drug Development Team, Children and Young People's Unit, Royal Marsden Hospital, Sutton, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zacharoulis</LastName><ForeName>Stergios</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Pediatric Oncology Drug Development Team, Children and Young People's Unit, Royal Marsden Hospital, Sutton, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vaidya</LastName><ForeName>Sucheta</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Pediatric Oncology Drug Development Team, Children and Young People's Unit, Royal Marsden Hospital, Sutton, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mandeville</LastName><ForeName>Henry C</ForeName><Initials>HC</Initials><AffiliationInfo><Affiliation>Department of Radiotherapy, Royal Marsden Hospital, Sutton, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bridges</LastName><ForeName>Leslie R</ForeName><Initials>LR</Initials><AffiliationInfo><Affiliation>Department of Cellular Pathology, St George's Hospital NHS Trust, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martin</LastName><ForeName>Andrew J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>Department of Neurosurgery, St George's Hospital NHS Trust, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Al-Sarraj</LastName><ForeName>Safa</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Neuropathology, Kings College Hospital, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chandler</LastName><ForeName>Christopher</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Neurosurgery, Kings College Hospital, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ng</LastName><ForeName>Ho-Keung</ForeName><Initials>HK</Initials><AffiliationInfo><Affiliation>Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Xingang</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Department of Neurosurgery, Qilu Hospital of Shandong University and Brain Science Research Institute, Shandong University, Jinan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mu</LastName><ForeName>Kun</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Pathology, Shandong University School of Medicine, Jinan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Trabelsi</LastName><ForeName>Saoussen</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Cytogenetics and Reproductive Biology, Farhat Hached Hospital, Sousse, Tunisia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brahim</LastName><ForeName>Dorra H'mida-Ben</ForeName><Initials>DH</Initials><AffiliationInfo><Affiliation>Department of Cytogenetics and Reproductive Biology, Farhat Hached Hospital, Sousse, Tunisia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kisljakov</LastName><ForeName>Alexei N</ForeName><Initials>AN</Initials><AffiliationInfo><Affiliation>Department of Pathology, Morozov Children's Hospital, Moscow, Russian Federation.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Konovalov</LastName><ForeName>Dmitry M</ForeName><Initials>DM</Initials><AffiliationInfo><Affiliation>Department of Pathology, Dmitrii Rogachev Research and Clinical Centre of Pediatric Hematology, Oncology and Immunology, Moscow, Russian Federation.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moore</LastName><ForeName>Andrew S</ForeName><Initials>AS</Initials><AffiliationInfo><Affiliation>UQ Child Health Research Centre, The University of Queensland, Brisbane, Australia; Oncology Services Group, Children's Health Queensland Hospital and Health Service, Brisbane, Australia; The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carcaboso</LastName><ForeName>Angel Montero</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Institut de Recerca Sant Joan de Deu, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sunol</LastName><ForeName>Mariona</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institut de Recerca Sant Joan de Deu, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Torres</LastName><ForeName>Carmen</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institut de Recerca Sant Joan de Deu, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cruz</LastName><ForeName>Ofelia</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Institut de Recerca Sant Joan de Deu, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mora</LastName><ForeName>Jaume</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Institut de Recerca Sant Joan de Deu, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shats</LastName><ForeName>Ludmila I</ForeName><Initials>LI</Initials><AffiliationInfo><Affiliation>Division of Oncology, Pediatric Oncology and Radiotherapy, St Petersburg State Pediatric Medical University, St Petersburg, Russian Federation.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stavale</LastName><ForeName>João N</ForeName><Initials>JN</Initials><AffiliationInfo><Affiliation>Department of Pathology, Federal University of São Paulo, São Paulo, São Paulo, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bidinotto</LastName><ForeName>Lucas T</ForeName><Initials>LT</Initials><AffiliationInfo><Affiliation>Molecular Oncology Research Centre, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reis</LastName><ForeName>Rui M</ForeName><Initials>RM</Initials><AffiliationInfo><Affiliation>Molecular Oncology Research Centre, Barretos Cancer Hospital, Barretos, São Paulo, Brazil; Life and Health Sciences Research Institute (ICVS), Medical School, University of Minho, Braga, Portugal and ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Entz-Werle</LastName><ForeName>Natacha</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Pédiatrie Onco-Hématologie - Pédiatrie III, Centre Hospitalier Régional et Universitaire Hautepierre, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Farrell</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Histopathology Department, Beaumont Hospital, Dublin, Ireland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cryan</LastName><ForeName>Jane</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Histopathology Department, Beaumont Hospital, Dublin, Ireland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Crimmins</LastName><ForeName>Darach</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Neurosurgery, Temple Street Children's University Hospital, Dublin, Ireland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Caird</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Neurosurgery, Temple Street Children's University Hospital, Dublin, Ireland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pears</LastName><ForeName>Jane</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Paediatric Oncology, Our Lady's Children's Hospital, Dublin, Ireland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Monje</LastName><ForeName>Michelle</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Neurology, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Debily</LastName><ForeName>Marie-Anne</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Département de Cancerologie de l'Enfant et de l'Adolescent, Institut Gustav Roussy, Villejuif, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Castel</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Département de Cancerologie de l'Enfant et de l'Adolescent, Institut Gustav Roussy, Villejuif, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grill</LastName><ForeName>Jacques</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Département de Cancerologie de l'Enfant et de l'Adolescent, Institut Gustav Roussy, Villejuif, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hawkins</LastName><ForeName>Cynthia</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Pediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nikbakht</LastName><ForeName>Hamid</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, McGill University, Montreal, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jabado</LastName><ForeName>Nada</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>The Center for Data Driven Discovery in Biomedicine (D(3)b), Children's Hospital of Philadelphia, Philadelphia, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baker</LastName><ForeName>Suzanne J</ForeName><Initials>SJ</Initials><AffiliationInfo><Affiliation>Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pfister</LastName><ForeName>Stefan M</ForeName><Initials>SM</Initials><AffiliationInfo><Affiliation>Division of Pediatric Neuro-oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany; Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jones</LastName><ForeName>David T W</ForeName><Initials>DTW</Initials><AffiliationInfo><Affiliation>Division of Pediatric Neuro-oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fouladi</LastName><ForeName>Maryam</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital, Cincinnati, OH, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>von Bueren</LastName><ForeName>André O</ForeName><Initials>AO</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Division of Pediatric Hematology and Oncology, University Medical Center Goettingen, Goettingen, Germany; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, University Hospital of Geneva, Geneva, Switzerland; Department of Pediatrics, CANSEARCH Research Laboratory, Faculty of Medicine, University of Geneva, Geneva, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baudis</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute of Molecular Life Sciences, Swiss Institute of Bioinformatics, University of Zürich, Zürich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Resnick</LastName><ForeName>Adam</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>The Center for Data Driven Discovery in Biomedicine (D(3)b), Children's Hospital of Philadelphia, Philadelphia, PA, USA; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jones</LastName><ForeName>Chris</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London, UK; Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK. Electronic address: chris.jones@icr.ac.uk.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 NS085336</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 NS091620</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D017418">Meta-Analysis</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>09</Month><Day>28</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Cancer Cell</MedlineTA><NlmUniqueID>101130617</NlmUniqueID><ISSNLinking>1535-6108</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C411984">BCOR protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018797">Cell Cycle Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D044783">F-Box Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006657">Histones</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011518">Proto-Oncogene Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012097">Repressor Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.3.2.27</RegistryNumber><NameOfSubstance UI="D044767">Ubiquitin-Protein Ligases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 5.99.1.2</RegistryNumber><NameOfSubstance UI="D004264">DNA Topoisomerases, Type I</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 5.99.1.2</RegistryNumber><NameOfSubstance UI="C061471">DNA topoisomerase III</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 6.3.2.19</RegistryNumber><NameOfSubstance UI="C513273">FBXW7 protein, human</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Nucleic Acids Res. 2014 Jan;42(Database issue):D1055-62</RefSource><PMID Version="1">24225322</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cancer Res. 2014 Sep 1;74(17):4565-70</RefSource><PMID Version="1">25136070</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Acta Neuropathol. 2016 Jun;131(6):803-20</RefSource><PMID Version="1">27157931</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Acta Neuropathol Commun. 2014 Feb 18;2:23</RefSource><PMID Version="1">24548782</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cancer Res. 2013 Oct 15;73(20):6219-29</RefSource><PMID Version="1">23970477</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2010 Jul 9;285(28):21426-36</RefSource><PMID Version="1">20445207</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cancer Cell. 2012 Oct 16;22(4):425-37</RefSource><PMID Version="1">23079654</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuro Oncol. 2017 Feb 1;19(2):153-161</RefSource><PMID Version="1">27282398</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuro Oncol. 2011 Feb;13(2):212-22</RefSource><PMID Version="1">21138945</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Cancer. 2014 Feb;14(2):92-107</RefSource><PMID Version="1">24457416</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Cancer. 2014 Oct;14(10):null</RefSource><PMID Version="1">25230881</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2014 May;46(5):462-6</RefSource><PMID Version="1">24705250</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuro Oncol. 2015 Oct;17 Suppl 4:iv1-iv62</RefSource><PMID Version="1">26511214</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Oncol. 2016 Jul 1;34(19):2206-11</RefSource><PMID Version="1">27001570</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Glia. 2016 Jun;64(6):879-95</RefSource><PMID Version="1">26638183</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Acta Neuropathol. 2013 May;125(5):659-69</RefSource><PMID Version="1">23417712</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2012 Jan 29;482(7384):226-31</RefSource><PMID Version="1">22286061</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Acta Neuropathol. 2015 Dec;130(6):815-27</RefSource><PMID Version="1">26399631</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cancer Cell. 2013 Nov 11;24(5):660-72</RefSource><PMID Version="1">24183680</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2015 Mar;47(3):257-62</RefSource><PMID Version="1">25642631</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Cancer Res. 2011 Dec 15;17(24):7595-604</RefSource><PMID Version="1">22038996</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Oncol. 2011 Oct 20;29(30):3999-4006</RefSource><PMID Version="1">21931021</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Cancer Res. 2010 Jul 1;16(13):3368-77</RefSource><PMID Version="1">20570930</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Acta Neuropathol. 2015 May;129(5):669-78</RefSource><PMID Version="1">25752754</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2014 May;46(5):451-6</RefSource><PMID Version="1">24705254</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell. 2016 Jan 28;164(3):550-63</RefSource><PMID Version="1">26824661</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2012;7(2):e30313</RefSource><PMID Version="1">22389665</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Med. 2016 Nov;22(11):1314-1320</RefSource><PMID Version="1">27748748</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell. 2017 Aug 24;170(5):845-859.e19</RefSource><PMID Version="1">28823557</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cancer Res. 2010 Jan 15;70(2):512-9</RefSource><PMID Version="1">20068183</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cancer Cell. 2014 Oct 13;26(4):455-64</RefSource><PMID Version="1">25314076</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Acta Neuropathol. 2012 Sep;124(3):439-47</RefSource><PMID Version="1">22661320</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genes Dev. 2013 May 1;27(9):985-90</RefSource><PMID Version="1">23603901</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cancer Cell. 2014 Dec 8;26(6):797-812</RefSource><PMID Version="1">25490446</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13726-13731</RefSource><PMID Version="1">27837025</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2017 Jan 4;12 (1):e0169485</RefSource><PMID Version="1">28052119</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2014 May;46(5):457-461</RefSource><PMID Version="1">24705252</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>EMBO J. 2004 May 19;23 (10 ):2116-25</RefSource><PMID Version="1">15103331</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Oncol. 2010 Jun 20;28(18):3061-8</RefSource><PMID Version="1">20479398</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2012;7(5):e36944</RefSource><PMID Version="1">22629346</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):9085-90</RefSource><PMID Version="1">15150404</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2014 May;46(5):444-450</RefSource><PMID Version="1">24705251</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>EMBO J. 2008 May 21;27(10 ):1513-24</RefSource><PMID Version="1">18418389</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cancer Discov. 2013 May;3(5):512-9</RefSource><PMID Version="1">23539269</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Acta Neuropathol. 2017 Apr 11;:null</RefSource><PMID Version="1">28401334</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Science. 2014 Dec 19;346(6216):1529-33</RefSource><PMID Version="1">25525250</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2014 Jul 24;511(7510):428-34</RefSource><PMID Version="1">25043047</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuro Oncol. 2011 Jun;13(6):680-9</RefSource><PMID Version="1">21636712</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Clin Oncol. 2012 May 29;9(7):400-13</RefSource><PMID Version="1">22641364</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Oncol. 2010 Mar 10;28(8):1337-44</RefSource><PMID Version="1">20142589</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2009 Sep 09;4(9):e6919</RefSource><PMID Version="1">19742304</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2012 Jan 29;44(3):251-3</RefSource><PMID Version="1">22286216</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Med. 2015 Jun;21(6):555-9</RefSource><PMID Version="1">25939062</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell. 2015 May 7;161(4):803-16</RefSource><PMID Version="1">25913192</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2000 Mar 31;275(13):9636-44</RefSource><PMID Version="1">10734115</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020295" MajorTopicYN="N">Brain Stem Neoplasms</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018797" MajorTopicYN="N">Cell Cycle Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004264" MajorTopicYN="N">DNA Topoisomerases, Type I</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D059472" MajorTopicYN="N">Exome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D044783" MajorTopicYN="N">F-Box Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018628" MajorTopicYN="N">Gene Dosage</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005910" MajorTopicYN="N">Glioma</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006657" MajorTopicYN="N">Histones</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007231" MajorTopicYN="N">Infant, Newborn</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009154" MajorTopicYN="Y">Mutation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011518" MajorTopicYN="N">Proto-Oncogene Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012097" MajorTopicYN="N">Repressor Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D044767" MajorTopicYN="N">Ubiquitin-Protein Ligases</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">DIPG</Keyword><Keyword MajorTopicYN="N">exome</Keyword><Keyword MajorTopicYN="N">genome</Keyword><Keyword MajorTopicYN="N">glioblastoma</Keyword><Keyword MajorTopicYN="N">histone</Keyword><Keyword MajorTopicYN="N">methylation</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>05</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2017</Year><Month>07</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>08</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>10</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>11</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>10</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28966033</ArticleId><ArticleId IdType="pii">S1535-6108(17)30362-8</ArticleId><ArticleId IdType="doi">10.1016/j.ccell.2017.08.017</ArticleId><ArticleId IdType="pmc">PMC5637314</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000398 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000398 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:28966033
|texte= Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:28966033" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |