When does atopic dermatitis warrant systemic therapy? Recommendations from an expert panel of the International Eczema Council.
Identifieur interne : 000297 ( PubMed/Corpus ); précédent : 000296; suivant : 000298When does atopic dermatitis warrant systemic therapy? Recommendations from an expert panel of the International Eczema Council.
Auteurs : Eric L. Simpson ; Marjolein Bruin-Weller ; Carsten Flohr ; Michael R. Ardern-Jones ; Sebastien Barbarot ; Mette Deleuran ; Thomas Bieber ; Christian Vestergaard ; Sara J. Brown ; Michael J. Cork ; Aaron M. Drucker ; Lawrence F. Eichenfield ; Regina Foelster-Holst ; Emma Guttman-Yassky ; Audrey Nosbaum ; Nick J. Reynolds ; Jonathan I. Silverberg ; Jochen Schmitt ; Marieke M B. Seyger ; Phyllis I. Spuls ; Jean-Francois Stalder ; John C. Su ; Roberto Takaoka ; Claudia Traidl-Hoffmann ; Jacob P. Thyssen ; Jorien Van Der Schaft ; Andreas Wollenberg ; Alan D. Irvine ; Amy S. PallerSource :
- Journal of the American Academy of Dermatology [ 1097-6787 ] ; 2017.
English descriptors
- KwdEn :
- Administration, Cutaneous, Administration, Oral, Biological Products (therapeutic use), Clinical Decision-Making, Dermatitis, Atopic (diagnosis), Dermatitis, Atopic (drug therapy), Dermatitis, Atopic (therapy), Dermatologic Agents (administration & dosage), Humans, Immunosuppressive Agents (administration & dosage), Immunosuppressive Agents (therapeutic use), Injections, Patient Education as Topic, Phototherapy, Quality of Life, Severity of Illness Index.
- MESH :
- chemical , administration & dosage : Dermatologic Agents, Immunosuppressive Agents.
- chemical , therapeutic use : Biological Products, Immunosuppressive Agents.
- diagnosis : Dermatitis, Atopic.
- drug therapy : Dermatitis, Atopic.
- therapy : Dermatitis, Atopic.
- Administration, Cutaneous, Administration, Oral, Clinical Decision-Making, Humans, Injections, Patient Education as Topic, Phototherapy, Quality of Life, Severity of Illness Index.
Abstract
Although most patients with atopic dermatitis (AD) are effectively managed with topical medication, a significant minority require systemic therapy. Guidelines for decision making about advancement to systemic therapy are lacking.
DOI: 10.1016/j.jaad.2017.06.042
PubMed: 28803668
Links to Exploration step
pubmed:28803668Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">When does atopic dermatitis warrant systemic therapy? Recommendations from an expert panel of the International Eczema Council.</title><author><name sortKey="Simpson, Eric L" sort="Simpson, Eric L" uniqKey="Simpson E" first="Eric L" last="Simpson">Eric L. Simpson</name><affiliation><nlm:affiliation>Department of Dermatology, Oregon Health and Science University, Portland, Oregon. Electronic address: simpsone@ohsu.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Bruin Weller, Marjolein" sort="Bruin Weller, Marjolein" uniqKey="Bruin Weller M" first="Marjolein" last="Bruin-Weller">Marjolein Bruin-Weller</name><affiliation><nlm:affiliation>National Expertise Center for Atopic Dermatitis, Department of Dermatology and Allergology, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Flohr, Carsten" sort="Flohr, Carsten" uniqKey="Flohr C" first="Carsten" last="Flohr">Carsten Flohr</name><affiliation><nlm:affiliation>Unit for Population-Based Dermatology Research, St John's Institute of Dermatology, Guy's and St Thomas' National Health Service Foundation Trust and King's College London, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Ardern Jones, Michael R" sort="Ardern Jones, Michael R" uniqKey="Ardern Jones M" first="Michael R" last="Ardern-Jones">Michael R. Ardern-Jones</name><affiliation><nlm:affiliation>Clinical Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Barbarot, Sebastien" sort="Barbarot, Sebastien" uniqKey="Barbarot S" first="Sebastien" last="Barbarot">Sebastien Barbarot</name><affiliation><nlm:affiliation>Department of Dermatology, Nantes University Hospital, Nantes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Deleuran, Mette" sort="Deleuran, Mette" uniqKey="Deleuran M" first="Mette" last="Deleuran">Mette Deleuran</name><affiliation><nlm:affiliation>Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Bieber, Thomas" sort="Bieber, Thomas" uniqKey="Bieber T" first="Thomas" last="Bieber">Thomas Bieber</name><affiliation><nlm:affiliation>Department of Dermatology and Allergy, University of Bonn, Bonn, Germany; Christine Kühne-Center for Allergy Research and Education, Davos, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Vestergaard, Christian" sort="Vestergaard, Christian" uniqKey="Vestergaard C" first="Christian" last="Vestergaard">Christian Vestergaard</name><affiliation><nlm:affiliation>Department of Dermatology Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Brown, Sara J" sort="Brown, Sara J" uniqKey="Brown S" first="Sara J" last="Brown">Sara J. Brown</name><affiliation><nlm:affiliation>Skin Research Group, School of Medicine, University of Dundee, Dundee, United Kingdom; Department of Dermatology, Ninewells Hospital and Medical School, Dundee, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Cork, Michael J" sort="Cork, Michael J" uniqKey="Cork M" first="Michael J" last="Cork">Michael J. Cork</name><affiliation><nlm:affiliation>Sheffield Dermatology Research Department of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Sheffield, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Drucker, Aaron M" sort="Drucker, Aaron M" uniqKey="Drucker A" first="Aaron M" last="Drucker">Aaron M. Drucker</name><affiliation><nlm:affiliation>Department of Dermatology, Alpert Medical School of Brown University, Providence, Rhode Island.</nlm:affiliation></affiliation></author><author><name sortKey="Eichenfield, Lawrence F" sort="Eichenfield, Lawrence F" uniqKey="Eichenfield L" first="Lawrence F" last="Eichenfield">Lawrence F. Eichenfield</name><affiliation><nlm:affiliation>Department of Dermatology, University of California, San Diego, California; Department of Pediatrics, University of California, San Diego, California; Rady Children's Hospital, San Diego, California.</nlm:affiliation></affiliation></author><author><name sortKey="Foelster Holst, Regina" sort="Foelster Holst, Regina" uniqKey="Foelster Holst R" first="Regina" last="Foelster-Holst">Regina Foelster-Holst</name><affiliation><nlm:affiliation>Dermatology, Venereology and Allergology, University of Schleswig-Holstein, Kiel, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Guttman Yassky, Emma" sort="Guttman Yassky, Emma" uniqKey="Guttman Yassky E" first="Emma" last="Guttman-Yassky">Emma Guttman-Yassky</name><affiliation><nlm:affiliation>Icahn School of Medicine at Mount Sinai Medical Center, New York, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Nosbaum, Audrey" sort="Nosbaum, Audrey" uniqKey="Nosbaum A" first="Audrey" last="Nosbaum">Audrey Nosbaum</name><affiliation><nlm:affiliation>Department of Allergy and Clinical Immunology, University Hospital Lyon Sud, Hospices Civiles de Lyon, Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Reynolds, Nick J" sort="Reynolds, Nick J" uniqKey="Reynolds N" first="Nick J" last="Reynolds">Nick J. Reynolds</name><affiliation><nlm:affiliation>Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Newcastle Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Silverberg, Jonathan I" sort="Silverberg, Jonathan I" uniqKey="Silverberg J" first="Jonathan I" last="Silverberg">Jonathan I. Silverberg</name><affiliation><nlm:affiliation>Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois.</nlm:affiliation></affiliation></author><author><name sortKey="Schmitt, Jochen" sort="Schmitt, Jochen" uniqKey="Schmitt J" first="Jochen" last="Schmitt">Jochen Schmitt</name><affiliation><nlm:affiliation>Center for Evidence-Based Healthcare, Technische Universität Dresden, Dresden, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Seyger, Marieke M B" sort="Seyger, Marieke M B" uniqKey="Seyger M" first="Marieke M B" last="Seyger">Marieke M B. Seyger</name><affiliation><nlm:affiliation>Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Spuls, Phyllis I" sort="Spuls, Phyllis I" uniqKey="Spuls P" first="Phyllis I" last="Spuls">Phyllis I. Spuls</name><affiliation><nlm:affiliation>Department of Dermatology, Academic Medical Centre, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Stalder, Jean Francois" sort="Stalder, Jean Francois" uniqKey="Stalder J" first="Jean-Francois" last="Stalder">Jean-Francois Stalder</name><affiliation><nlm:affiliation>Department of Dermatology, Nantes University Hospital, Nantes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Su, John C" sort="Su, John C" uniqKey="Su J" first="John C" last="Su">John C. Su</name><affiliation><nlm:affiliation>Department of Dermatology, Monash University, Eastern Health and Murdoch Childrens Research Institute, University of Melbourne, Melbourne, Australia; Department of Paediatrics, Monash University, Eastern Health and Murdoch Childrens Research Institute, University of Melbourne, Melbourne, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Takaoka, Roberto" sort="Takaoka, Roberto" uniqKey="Takaoka R" first="Roberto" last="Takaoka">Roberto Takaoka</name><affiliation><nlm:affiliation>Department of Dermatology, University of São Paulo Medical School, São Paulo, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Traidl Hoffmann, Claudia" sort="Traidl Hoffmann, Claudia" uniqKey="Traidl Hoffmann C" first="Claudia" last="Traidl-Hoffmann">Claudia Traidl-Hoffmann</name><affiliation><nlm:affiliation>Institute of Environmental Medicine, UNIKA-T, Technical University of Munich and Helmholtz Zentrum München-German Research Center for Environmental Health (GmbH), Munich, Germany; CK CARE, Christine-Kühne-Center for Allergy Research and Education, Davos, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Thyssen, Jacob P" sort="Thyssen, Jacob P" uniqKey="Thyssen J" first="Jacob P" last="Thyssen">Jacob P. Thyssen</name><affiliation><nlm:affiliation>Department of Dermatology and Allergy, Herlev-Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Van Der Schaft, Jorien" sort="Van Der Schaft, Jorien" uniqKey="Van Der Schaft J" first="Jorien" last="Van Der Schaft">Jorien Van Der Schaft</name><affiliation><nlm:affiliation>Department of Dermatology and Allergology, University Medical Centre Utrech, Utrecht, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Wollenberg, Andreas" sort="Wollenberg, Andreas" uniqKey="Wollenberg A" first="Andreas" last="Wollenberg">Andreas Wollenberg</name><affiliation><nlm:affiliation>Department of Dermatology and Allergy, Ludwig-Maximilian-University Munich, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Irvine, Alan D" sort="Irvine, Alan D" uniqKey="Irvine A" first="Alan D" last="Irvine">Alan D. Irvine</name><affiliation><nlm:affiliation>Trinity College Dublin, National Children's Research Centre, Paediatric Dermatology Our Lady's Children's Hospital, Dublin, United Kingdom. Electronic address: irvinea@tcd.ie.</nlm:affiliation></affiliation></author><author><name sortKey="Paller, Amy S" sort="Paller, Amy S" uniqKey="Paller A" first="Amy S" last="Paller">Amy S. Paller</name><affiliation><nlm:affiliation>Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois. Electronic address: apaller@northwestern.edu.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28803668</idno><idno type="pmid">28803668</idno><idno type="doi">10.1016/j.jaad.2017.06.042</idno><idno type="wicri:Area/PubMed/Corpus">000297</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000297</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">When does atopic dermatitis warrant systemic therapy? Recommendations from an expert panel of the International Eczema Council.</title><author><name sortKey="Simpson, Eric L" sort="Simpson, Eric L" uniqKey="Simpson E" first="Eric L" last="Simpson">Eric L. Simpson</name><affiliation><nlm:affiliation>Department of Dermatology, Oregon Health and Science University, Portland, Oregon. Electronic address: simpsone@ohsu.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Bruin Weller, Marjolein" sort="Bruin Weller, Marjolein" uniqKey="Bruin Weller M" first="Marjolein" last="Bruin-Weller">Marjolein Bruin-Weller</name><affiliation><nlm:affiliation>National Expertise Center for Atopic Dermatitis, Department of Dermatology and Allergology, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Flohr, Carsten" sort="Flohr, Carsten" uniqKey="Flohr C" first="Carsten" last="Flohr">Carsten Flohr</name><affiliation><nlm:affiliation>Unit for Population-Based Dermatology Research, St John's Institute of Dermatology, Guy's and St Thomas' National Health Service Foundation Trust and King's College London, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Ardern Jones, Michael R" sort="Ardern Jones, Michael R" uniqKey="Ardern Jones M" first="Michael R" last="Ardern-Jones">Michael R. Ardern-Jones</name><affiliation><nlm:affiliation>Clinical Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Barbarot, Sebastien" sort="Barbarot, Sebastien" uniqKey="Barbarot S" first="Sebastien" last="Barbarot">Sebastien Barbarot</name><affiliation><nlm:affiliation>Department of Dermatology, Nantes University Hospital, Nantes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Deleuran, Mette" sort="Deleuran, Mette" uniqKey="Deleuran M" first="Mette" last="Deleuran">Mette Deleuran</name><affiliation><nlm:affiliation>Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Bieber, Thomas" sort="Bieber, Thomas" uniqKey="Bieber T" first="Thomas" last="Bieber">Thomas Bieber</name><affiliation><nlm:affiliation>Department of Dermatology and Allergy, University of Bonn, Bonn, Germany; Christine Kühne-Center for Allergy Research and Education, Davos, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Vestergaard, Christian" sort="Vestergaard, Christian" uniqKey="Vestergaard C" first="Christian" last="Vestergaard">Christian Vestergaard</name><affiliation><nlm:affiliation>Department of Dermatology Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Brown, Sara J" sort="Brown, Sara J" uniqKey="Brown S" first="Sara J" last="Brown">Sara J. Brown</name><affiliation><nlm:affiliation>Skin Research Group, School of Medicine, University of Dundee, Dundee, United Kingdom; Department of Dermatology, Ninewells Hospital and Medical School, Dundee, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Cork, Michael J" sort="Cork, Michael J" uniqKey="Cork M" first="Michael J" last="Cork">Michael J. Cork</name><affiliation><nlm:affiliation>Sheffield Dermatology Research Department of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Sheffield, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Drucker, Aaron M" sort="Drucker, Aaron M" uniqKey="Drucker A" first="Aaron M" last="Drucker">Aaron M. Drucker</name><affiliation><nlm:affiliation>Department of Dermatology, Alpert Medical School of Brown University, Providence, Rhode Island.</nlm:affiliation></affiliation></author><author><name sortKey="Eichenfield, Lawrence F" sort="Eichenfield, Lawrence F" uniqKey="Eichenfield L" first="Lawrence F" last="Eichenfield">Lawrence F. Eichenfield</name><affiliation><nlm:affiliation>Department of Dermatology, University of California, San Diego, California; Department of Pediatrics, University of California, San Diego, California; Rady Children's Hospital, San Diego, California.</nlm:affiliation></affiliation></author><author><name sortKey="Foelster Holst, Regina" sort="Foelster Holst, Regina" uniqKey="Foelster Holst R" first="Regina" last="Foelster-Holst">Regina Foelster-Holst</name><affiliation><nlm:affiliation>Dermatology, Venereology and Allergology, University of Schleswig-Holstein, Kiel, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Guttman Yassky, Emma" sort="Guttman Yassky, Emma" uniqKey="Guttman Yassky E" first="Emma" last="Guttman-Yassky">Emma Guttman-Yassky</name><affiliation><nlm:affiliation>Icahn School of Medicine at Mount Sinai Medical Center, New York, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Nosbaum, Audrey" sort="Nosbaum, Audrey" uniqKey="Nosbaum A" first="Audrey" last="Nosbaum">Audrey Nosbaum</name><affiliation><nlm:affiliation>Department of Allergy and Clinical Immunology, University Hospital Lyon Sud, Hospices Civiles de Lyon, Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Reynolds, Nick J" sort="Reynolds, Nick J" uniqKey="Reynolds N" first="Nick J" last="Reynolds">Nick J. Reynolds</name><affiliation><nlm:affiliation>Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Newcastle Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Silverberg, Jonathan I" sort="Silverberg, Jonathan I" uniqKey="Silverberg J" first="Jonathan I" last="Silverberg">Jonathan I. Silverberg</name><affiliation><nlm:affiliation>Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois.</nlm:affiliation></affiliation></author><author><name sortKey="Schmitt, Jochen" sort="Schmitt, Jochen" uniqKey="Schmitt J" first="Jochen" last="Schmitt">Jochen Schmitt</name><affiliation><nlm:affiliation>Center for Evidence-Based Healthcare, Technische Universität Dresden, Dresden, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Seyger, Marieke M B" sort="Seyger, Marieke M B" uniqKey="Seyger M" first="Marieke M B" last="Seyger">Marieke M B. Seyger</name><affiliation><nlm:affiliation>Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Spuls, Phyllis I" sort="Spuls, Phyllis I" uniqKey="Spuls P" first="Phyllis I" last="Spuls">Phyllis I. Spuls</name><affiliation><nlm:affiliation>Department of Dermatology, Academic Medical Centre, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Stalder, Jean Francois" sort="Stalder, Jean Francois" uniqKey="Stalder J" first="Jean-Francois" last="Stalder">Jean-Francois Stalder</name><affiliation><nlm:affiliation>Department of Dermatology, Nantes University Hospital, Nantes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Su, John C" sort="Su, John C" uniqKey="Su J" first="John C" last="Su">John C. Su</name><affiliation><nlm:affiliation>Department of Dermatology, Monash University, Eastern Health and Murdoch Childrens Research Institute, University of Melbourne, Melbourne, Australia; Department of Paediatrics, Monash University, Eastern Health and Murdoch Childrens Research Institute, University of Melbourne, Melbourne, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Takaoka, Roberto" sort="Takaoka, Roberto" uniqKey="Takaoka R" first="Roberto" last="Takaoka">Roberto Takaoka</name><affiliation><nlm:affiliation>Department of Dermatology, University of São Paulo Medical School, São Paulo, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Traidl Hoffmann, Claudia" sort="Traidl Hoffmann, Claudia" uniqKey="Traidl Hoffmann C" first="Claudia" last="Traidl-Hoffmann">Claudia Traidl-Hoffmann</name><affiliation><nlm:affiliation>Institute of Environmental Medicine, UNIKA-T, Technical University of Munich and Helmholtz Zentrum München-German Research Center for Environmental Health (GmbH), Munich, Germany; CK CARE, Christine-Kühne-Center for Allergy Research and Education, Davos, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Thyssen, Jacob P" sort="Thyssen, Jacob P" uniqKey="Thyssen J" first="Jacob P" last="Thyssen">Jacob P. Thyssen</name><affiliation><nlm:affiliation>Department of Dermatology and Allergy, Herlev-Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Van Der Schaft, Jorien" sort="Van Der Schaft, Jorien" uniqKey="Van Der Schaft J" first="Jorien" last="Van Der Schaft">Jorien Van Der Schaft</name><affiliation><nlm:affiliation>Department of Dermatology and Allergology, University Medical Centre Utrech, Utrecht, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Wollenberg, Andreas" sort="Wollenberg, Andreas" uniqKey="Wollenberg A" first="Andreas" last="Wollenberg">Andreas Wollenberg</name><affiliation><nlm:affiliation>Department of Dermatology and Allergy, Ludwig-Maximilian-University Munich, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Irvine, Alan D" sort="Irvine, Alan D" uniqKey="Irvine A" first="Alan D" last="Irvine">Alan D. Irvine</name><affiliation><nlm:affiliation>Trinity College Dublin, National Children's Research Centre, Paediatric Dermatology Our Lady's Children's Hospital, Dublin, United Kingdom. Electronic address: irvinea@tcd.ie.</nlm:affiliation></affiliation></author><author><name sortKey="Paller, Amy S" sort="Paller, Amy S" uniqKey="Paller A" first="Amy S" last="Paller">Amy S. Paller</name><affiliation><nlm:affiliation>Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois. Electronic address: apaller@northwestern.edu.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of the American Academy of Dermatology</title><idno type="eISSN">1097-6787</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Cutaneous</term><term>Administration, Oral</term><term>Biological Products (therapeutic use)</term><term>Clinical Decision-Making</term><term>Dermatitis, Atopic (diagnosis)</term><term>Dermatitis, Atopic (drug therapy)</term><term>Dermatitis, Atopic (therapy)</term><term>Dermatologic Agents (administration & dosage)</term><term>Humans</term><term>Immunosuppressive Agents (administration & dosage)</term><term>Immunosuppressive Agents (therapeutic use)</term><term>Injections</term><term>Patient Education as Topic</term><term>Phototherapy</term><term>Quality of Life</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Dermatologic Agents</term><term>Immunosuppressive Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Biological Products</term><term>Immunosuppressive Agents</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Dermatitis, Atopic</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Dermatitis, Atopic</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Dermatitis, Atopic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Cutaneous</term><term>Administration, Oral</term><term>Clinical Decision-Making</term><term>Humans</term><term>Injections</term><term>Patient Education as Topic</term><term>Phototherapy</term><term>Quality of Life</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although most patients with atopic dermatitis (AD) are effectively managed with topical medication, a significant minority require systemic therapy. Guidelines for decision making about advancement to systemic therapy are lacking.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28803668</PMID><DateCreated><Year>2017</Year><Month>08</Month><Day>14</Day></DateCreated><DateCompleted><Year>2017</Year><Month>09</Month><Day>27</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>27</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1097-6787</ISSN><JournalIssue CitedMedium="Internet"><Volume>77</Volume><Issue>4</Issue><PubDate><Year>2017</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Journal of the American Academy of Dermatology</Title><ISOAbbreviation>J. Am. Acad. Dermatol.</ISOAbbreviation></Journal><ArticleTitle>When does atopic dermatitis warrant systemic therapy? Recommendations from an expert panel of the International Eczema Council.</ArticleTitle><Pagination><MedlinePgn>623-633</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0190-9622(17)31944-8</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jaad.2017.06.042</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Although most patients with atopic dermatitis (AD) are effectively managed with topical medication, a significant minority require systemic therapy. Guidelines for decision making about advancement to systemic therapy are lacking.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To guide those considering use of systemic therapy in AD and provide a framework for evaluation before making this therapeutic decision with the patient.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A subgroup of the International Eczema Council determined aspects to consider before prescribing systemic therapy. Topics were assigned to expert reviewers who performed a topic-specific literature review, referred to guidelines when available, and provided interpretation and expert opinion.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">We recommend a systematic and holistic approach to assess patients with severe signs and symptoms of AD and impact on quality of life before systemic therapy. Steps taken before commencing systemic therapy include considering alternate or concomitant diagnoses, avoiding trigger factors, optimizing topical therapy, ensuring adequate patient/caregiver education, treating coexistent infection, assessing the impact on quality of life, and considering phototherapy.</AbstractText><AbstractText Label="LIMITATIONS" NlmCategory="CONCLUSIONS">Our work is a consensus statement, not a systematic review.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The decision to start systemic medication should include assessment of severity and quality of life while considering the individual's general health status, psychologic needs, and personal attitudes toward systemic therapies.</AbstractText><CopyrightInformation>Copyright © 2017 American Academy of Dermatology, Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Simpson</LastName><ForeName>Eric L</ForeName><Initials>EL</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Oregon Health and Science University, Portland, Oregon. Electronic address: simpsone@ohsu.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bruin-Weller</LastName><ForeName>Marjolein</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>National Expertise Center for Atopic Dermatitis, Department of Dermatology and Allergology, University Medical Center Utrecht, Utrecht, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Flohr</LastName><ForeName>Carsten</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Unit for Population-Based Dermatology Research, St John's Institute of Dermatology, Guy's and St Thomas' National Health Service Foundation Trust and King's College London, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ardern-Jones</LastName><ForeName>Michael R</ForeName><Initials>MR</Initials><AffiliationInfo><Affiliation>Clinical Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barbarot</LastName><ForeName>Sebastien</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Nantes University Hospital, Nantes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deleuran</LastName><ForeName>Mette</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bieber</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Dermatology and Allergy, University of Bonn, Bonn, Germany; Christine Kühne-Center for Allergy Research and Education, Davos, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vestergaard</LastName><ForeName>Christian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Dermatology Aarhus University Hospital, Aarhus, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brown</LastName><ForeName>Sara J</ForeName><Initials>SJ</Initials><AffiliationInfo><Affiliation>Skin Research Group, School of Medicine, University of Dundee, Dundee, United Kingdom; Department of Dermatology, Ninewells Hospital and Medical School, Dundee, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cork</LastName><ForeName>Michael J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Sheffield Dermatology Research Department of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Sheffield, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Drucker</LastName><ForeName>Aaron M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Alpert Medical School of Brown University, Providence, Rhode Island.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eichenfield</LastName><ForeName>Lawrence F</ForeName><Initials>LF</Initials><AffiliationInfo><Affiliation>Department of Dermatology, University of California, San Diego, California; Department of Pediatrics, University of California, San Diego, California; Rady Children's Hospital, San Diego, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Foelster-Holst</LastName><ForeName>Regina</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Dermatology, Venereology and Allergology, University of Schleswig-Holstein, Kiel, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guttman-Yassky</LastName><ForeName>Emma</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Icahn School of Medicine at Mount Sinai Medical Center, New York, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nosbaum</LastName><ForeName>Audrey</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Allergy and Clinical Immunology, University Hospital Lyon Sud, Hospices Civiles de Lyon, Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reynolds</LastName><ForeName>Nick J</ForeName><Initials>NJ</Initials><AffiliationInfo><Affiliation>Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Newcastle Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Silverberg</LastName><ForeName>Jonathan I</ForeName><Initials>JI</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schmitt</LastName><ForeName>Jochen</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Center for Evidence-Based Healthcare, Technische Universität Dresden, Dresden, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seyger</LastName><ForeName>Marieke M B</ForeName><Initials>MMB</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Spuls</LastName><ForeName>Phyllis I</ForeName><Initials>PI</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Academic Medical Centre, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stalder</LastName><ForeName>Jean-Francois</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Nantes University Hospital, Nantes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Su</LastName><ForeName>John C</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Monash University, Eastern Health and Murdoch Childrens Research Institute, University of Melbourne, Melbourne, Australia; Department of Paediatrics, Monash University, Eastern Health and Murdoch Childrens Research Institute, University of Melbourne, Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Takaoka</LastName><ForeName>Roberto</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Dermatology, University of São Paulo Medical School, São Paulo, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Traidl-Hoffmann</LastName><ForeName>Claudia</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institute of Environmental Medicine, UNIKA-T, Technical University of Munich and Helmholtz Zentrum München-German Research Center for Environmental Health (GmbH), Munich, Germany; CK CARE, Christine-Kühne-Center for Allergy Research and Education, Davos, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thyssen</LastName><ForeName>Jacob P</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Department of Dermatology and Allergy, Herlev-Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van der Schaft</LastName><ForeName>Jorien</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Dermatology and Allergology, University Medical Centre Utrech, Utrecht, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wollenberg</LastName><ForeName>Andreas</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Dermatology and Allergy, Ludwig-Maximilian-University Munich, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Irvine</LastName><ForeName>Alan D</ForeName><Initials>AD</Initials><AffiliationInfo><Affiliation>Trinity College Dublin, National Children's Research Centre, Paediatric Dermatology Our Lady's Children's Hospital, Dublin, United Kingdom. Electronic address: irvinea@tcd.ie.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Paller</LastName><ForeName>Amy S</ForeName><Initials>AS</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois. Electronic address: apaller@northwestern.edu.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016446">Consensus Development Conference</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>08</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Am Acad Dermatol</MedlineTA><NlmUniqueID>7907132</NlmUniqueID><ISSNLinking>0190-9622</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001688">Biological Products</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003879">Dermatologic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007166">Immunosuppressive Agents</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000279" MajorTopicYN="N">Administration, Cutaneous</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000284" MajorTopicYN="N">Administration, Oral</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001688" MajorTopicYN="N">Biological Products</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000066491" MajorTopicYN="N">Clinical Decision-Making</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003876" MajorTopicYN="N">Dermatitis, Atopic</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003879" MajorTopicYN="N">Dermatologic Agents</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007166" MajorTopicYN="N">Immunosuppressive Agents</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007267" MajorTopicYN="N">Injections</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010353" MajorTopicYN="N">Patient Education as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010789" MajorTopicYN="N">Phototherapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011788" MajorTopicYN="N">Quality of Life</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">atopic dermatitis</Keyword><Keyword MajorTopicYN="N">azathioprine</Keyword><Keyword MajorTopicYN="N">biologic</Keyword><Keyword MajorTopicYN="N">consensus statement</Keyword><Keyword MajorTopicYN="N">cyclosporine</Keyword><Keyword MajorTopicYN="N">eczema</Keyword><Keyword MajorTopicYN="N">methotrexate</Keyword><Keyword MajorTopicYN="N">quality of life</Keyword><Keyword MajorTopicYN="N">systemic therapy</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>04</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2017</Year><Month>06</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>06</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>8</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>9</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>8</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28803668</ArticleId><ArticleId IdType="pii">S0190-9622(17)31944-8</ArticleId><ArticleId IdType="doi">10.1016/j.jaad.2017.06.042</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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