Cannabis use by women during pregnancy does not influence infant DNA methylation of the dopamine receptor DRD4.
Identifieur interne : 000216 ( PubMed/Corpus ); précédent : 000215; suivant : 000217Cannabis use by women during pregnancy does not influence infant DNA methylation of the dopamine receptor DRD4.
Auteurs : Peter D. Fransquet ; Delyse Hutchinson ; Craig A. Olsson ; Steve Allsop ; Elizabeth J. Elliott ; Lucinda Burns ; Richard Mattick ; Richard Saffery ; Joanne RyanSource :
- The American journal of drug and alcohol abuse [ 1097-9891 ] ; 2017.
Abstract
Maternal cannabis use in pregnancy is linked with long-term adverse behavioral outcomes in offspring. Epigenetic processes established in utero that affect dopaminergic (reward) signaling may mediate risks. Associations between cannabis use and offspring DNA methylation have not been investigated; however, maternal tobacco smoking in pregnancy is associated with distinct patterns of DNA methylation at birth and beyond.
DOI: 10.1080/00952990.2017.1314488
PubMed: 28448718
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cannabis use by women during pregnancy does not influence infant DNA methylation of the dopamine receptor DRD4.</title><author><name sortKey="Fransquet, Peter D" sort="Fransquet, Peter D" uniqKey="Fransquet P" first="Peter D" last="Fransquet">Peter D. Fransquet</name><affiliation><nlm:affiliation>a Murdoch Childrens Research Institute, The University of Melbourne , Parkville , Victoria , Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Hutchinson, Delyse" sort="Hutchinson, Delyse" uniqKey="Hutchinson D" first="Delyse" last="Hutchinson">Delyse Hutchinson</name><affiliation><nlm:affiliation>a Murdoch Childrens Research Institute, The University of Melbourne , Parkville , Victoria , Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Olsson, Craig A" sort="Olsson, Craig A" uniqKey="Olsson C" first="Craig A" last="Olsson">Craig A. Olsson</name><affiliation><nlm:affiliation>a Murdoch Childrens Research Institute, The University of Melbourne , Parkville , Victoria , Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Allsop, Steve" sort="Allsop, Steve" uniqKey="Allsop S" first="Steve" last="Allsop">Steve Allsop</name><affiliation><nlm:affiliation>e National Drug Research Institute , Curtin University , Perth , Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Elliott, Elizabeth J" sort="Elliott, Elizabeth J" uniqKey="Elliott E" first="Elizabeth J" last="Elliott">Elizabeth J. Elliott</name><affiliation><nlm:affiliation>f Discipline of Paediatrics and Child Health , The University of Sydney, The Sydney Children's Hospital's Network (Westmead) , Sydney , Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Burns, Lucinda" sort="Burns, Lucinda" uniqKey="Burns L" first="Lucinda" last="Burns">Lucinda Burns</name><affiliation><nlm:affiliation>b Department of Paediatrics , University of Melbourne, Royal Children's Hospital , Melbourne , Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Mattick, Richard" sort="Mattick, Richard" uniqKey="Mattick R" first="Richard" last="Mattick">Richard Mattick</name><affiliation><nlm:affiliation>d National Drug and Alcohol Research Centre, University of New South Wales , Sydney , Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Saffery, Richard" sort="Saffery, Richard" uniqKey="Saffery R" first="Richard" last="Saffery">Richard Saffery</name><affiliation><nlm:affiliation>a Murdoch Childrens Research Institute, The University of Melbourne , Parkville , Victoria , Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Ryan, Joanne" sort="Ryan, Joanne" uniqKey="Ryan J" first="Joanne" last="Ryan">Joanne Ryan</name><affiliation><nlm:affiliation>a Murdoch Childrens Research Institute, The University of Melbourne , Parkville , Victoria , Australia.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28448718</idno><idno type="pmid">28448718</idno><idno type="doi">10.1080/00952990.2017.1314488</idno><idno type="wicri:Area/PubMed/Corpus">000216</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000216</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cannabis use by women during pregnancy does not influence infant DNA methylation of the dopamine receptor DRD4.</title><author><name sortKey="Fransquet, Peter D" sort="Fransquet, Peter D" uniqKey="Fransquet P" first="Peter D" last="Fransquet">Peter D. Fransquet</name><affiliation><nlm:affiliation>a Murdoch Childrens Research Institute, The University of Melbourne , Parkville , Victoria , Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Hutchinson, Delyse" sort="Hutchinson, Delyse" uniqKey="Hutchinson D" first="Delyse" last="Hutchinson">Delyse Hutchinson</name><affiliation><nlm:affiliation>a Murdoch Childrens Research Institute, The University of Melbourne , Parkville , Victoria , Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Olsson, Craig A" sort="Olsson, Craig A" uniqKey="Olsson C" first="Craig A" last="Olsson">Craig A. Olsson</name><affiliation><nlm:affiliation>a Murdoch Childrens Research Institute, The University of Melbourne , Parkville , Victoria , Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Allsop, Steve" sort="Allsop, Steve" uniqKey="Allsop S" first="Steve" last="Allsop">Steve Allsop</name><affiliation><nlm:affiliation>e National Drug Research Institute , Curtin University , Perth , Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Elliott, Elizabeth J" sort="Elliott, Elizabeth J" uniqKey="Elliott E" first="Elizabeth J" last="Elliott">Elizabeth J. Elliott</name><affiliation><nlm:affiliation>f Discipline of Paediatrics and Child Health , The University of Sydney, The Sydney Children's Hospital's Network (Westmead) , Sydney , Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Burns, Lucinda" sort="Burns, Lucinda" uniqKey="Burns L" first="Lucinda" last="Burns">Lucinda Burns</name><affiliation><nlm:affiliation>b Department of Paediatrics , University of Melbourne, Royal Children's Hospital , Melbourne , Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Mattick, Richard" sort="Mattick, Richard" uniqKey="Mattick R" first="Richard" last="Mattick">Richard Mattick</name><affiliation><nlm:affiliation>d National Drug and Alcohol Research Centre, University of New South Wales , Sydney , Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Saffery, Richard" sort="Saffery, Richard" uniqKey="Saffery R" first="Richard" last="Saffery">Richard Saffery</name><affiliation><nlm:affiliation>a Murdoch Childrens Research Institute, The University of Melbourne , Parkville , Victoria , Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Ryan, Joanne" sort="Ryan, Joanne" uniqKey="Ryan J" first="Joanne" last="Ryan">Joanne Ryan</name><affiliation><nlm:affiliation>a Murdoch Childrens Research Institute, The University of Melbourne , Parkville , Victoria , Australia.</nlm:affiliation></affiliation></author></analytic><series><title level="j">The American journal of drug and alcohol abuse</title><idno type="eISSN">1097-9891</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Maternal cannabis use in pregnancy is linked with long-term adverse behavioral outcomes in offspring. Epigenetic processes established in utero that affect dopaminergic (reward) signaling may mediate risks. Associations between cannabis use and offspring DNA methylation have not been investigated; however, maternal tobacco smoking in pregnancy is associated with distinct patterns of DNA methylation at birth and beyond.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28448718</PMID><DateCreated><Year>2017</Year><Month>04</Month><Day>27</Day></DateCreated><DateRevised><Year>2017</Year><Month>11</Month><Day>06</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1097-9891</ISSN><JournalIssue CitedMedium="Internet"><Volume>43</Volume><Issue>6</Issue><PubDate><Year>2017</Year><Month>Nov</Month></PubDate></JournalIssue><Title>The American journal of drug and alcohol abuse</Title><ISOAbbreviation>Am J Drug Alcohol Abuse</ISOAbbreviation></Journal><ArticleTitle>Cannabis use by women during pregnancy does not influence infant DNA methylation of the dopamine receptor DRD4.</ArticleTitle><Pagination><MedlinePgn>671-677</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/00952990.2017.1314488</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Maternal cannabis use in pregnancy is linked with long-term adverse behavioral outcomes in offspring. Epigenetic processes established in utero that affect dopaminergic (reward) signaling may mediate risks. Associations between cannabis use and offspring DNA methylation have not been investigated; however, maternal tobacco smoking in pregnancy is associated with distinct patterns of DNA methylation at birth and beyond.</AbstractText><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To determine whether maternal cannabis use is associated with methylation of the dopamine receptor gene DRD4 promoter in infants.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Mothers in the Triple B study provided detailed information on drug use in each trimester of pregnancy. Buccal swabs were collected from neonates at 8 weeks (n = 804, 51.7% male, and 48.3% female). DRD4 promoter DNA methylation was measured using SEQUENOM MassARRAY.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Fifty-seven of the women in the study reported drug use during pregnancy, of whom 44 used cannabis. Of 19 cytosine-phosphate-guanine dinucleotides (CpG) units tested in DRD4, gestational cannabis use was associated with offspring methylation at 1 CpG unit in multivariate models (β + 1.48, CI: 0.02 to 2.93, and p = 0.047). At another site there was weak evidence that both cannabis and other drug use were independently associated with increased methylation, while the association with tobacco was in the reverse direction (cannabis use β + 0.67, CI: -0.12 to 1.46, and p = 0.09; other drug use β + 1.11, CI: 0.17 to 2.05, and p = 0.02; tobacco use β -0.41, CI: -0.85 to 0.03, and p = 0.07). None of the associations would remain significant after correction for multiple testing.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">There is no strong evidence that maternal cannabis use in pregnancy is associated with offspring DRD4 methylation.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Fransquet</LastName><ForeName>Peter D</ForeName><Initials>PD</Initials><AffiliationInfo><Affiliation>a Murdoch Childrens Research Institute, The University of Melbourne , Parkville , Victoria , Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>b Department of Paediatrics , University of Melbourne, Royal Children's Hospital , Melbourne , Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>h School of Public Health and Preventive Medicine, Monash University , Melbourne , Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hutchinson</LastName><ForeName>Delyse</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>a Murdoch Childrens Research Institute, The University of Melbourne , Parkville , Victoria , Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>b Department of Paediatrics , University of Melbourne, Royal Children's Hospital , Melbourne , Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>c Centre for Social and Early Emotional Development, School of Psychology, Faculty of Health , Deakin University , Melbourne , Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>d National Drug and Alcohol Research Centre, University of New South Wales , Sydney , Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Olsson</LastName><ForeName>Craig A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>a Murdoch Childrens Research Institute, The University of Melbourne , Parkville , Victoria , Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>b Department of Paediatrics , University of Melbourne, Royal Children's Hospital , Melbourne , Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>c Centre for Social and Early Emotional Development, School of Psychology, Faculty of Health , Deakin University , Melbourne , Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Allsop</LastName><ForeName>Steve</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>e National Drug Research Institute , Curtin University , Perth , Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Elliott</LastName><ForeName>Elizabeth J</ForeName><Initials>EJ</Initials><AffiliationInfo><Affiliation>f Discipline of Paediatrics and Child Health , The University of Sydney, The Sydney Children's Hospital's Network (Westmead) , Sydney , Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Burns</LastName><ForeName>Lucinda</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>b Department of Paediatrics , University of Melbourne, Royal Children's Hospital , Melbourne , Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mattick</LastName><ForeName>Richard</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>d National Drug and Alcohol Research Centre, University of New South Wales , Sydney , Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Saffery</LastName><ForeName>Richard</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>a Murdoch Childrens Research Institute, The University of Melbourne , Parkville , Victoria , Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>b Department of Paediatrics , University of Melbourne, Royal Children's Hospital , Melbourne , Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ryan</LastName><ForeName>Joanne</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>a Murdoch Childrens Research Institute, The University of Melbourne , Parkville , Victoria , Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>b Department of Paediatrics , University of Melbourne, Royal Children's Hospital , Melbourne , Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>g Inserm U1061 , Montpellier , France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>h School of Public Health and Preventive Medicine, Monash University , Melbourne , Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>04</Month><Day>27</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Am J Drug Alcohol Abuse</MedlineTA><NlmUniqueID>7502510</NlmUniqueID><ISSNLinking>0095-2990</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Cannabis</Keyword><Keyword MajorTopicYN="N">DNA methylation</Keyword><Keyword MajorTopicYN="N">dopamine receptor (DRD4)</Keyword><Keyword MajorTopicYN="N">epigenetics</Keyword><Keyword MajorTopicYN="N">fetal programming</Keyword><Keyword MajorTopicYN="N">perinatal</Keyword><Keyword MajorTopicYN="N">pregnancy</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>4</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>4</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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