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Genetic Variants Related to Longer Telomere Length are Associated with Increased Risk of Renal Cell Carcinoma.

Identifieur interne : 000194 ( PubMed/Corpus ); précédent : 000193; suivant : 000195

Genetic Variants Related to Longer Telomere Length are Associated with Increased Risk of Renal Cell Carcinoma.

Auteurs : Mitchell J. Machiela ; Jonathan N. Hofmann ; Robert Carreras-Torres ; Kevin M. Brown ; Mattias Johansson ; Zhaoming Wang ; Matthieu Foll ; Peng Li ; Nathaniel Rothman ; Sharon A. Savage ; Valerie Gaborieau ; James D. Mckay ; Yuanqing Ye ; Marc Henrion ; Fiona Bruinsma ; Susan Jordan ; Gianluca Severi ; Kristian Hveem ; Lars J. Vatten ; Tony Fletcher ; Kvetoslava Koppova ; Susanna C. Larsson ; Alicja Wolk ; Rosamonde E. Banks ; Peter J. Selby ; Douglas F. Easton ; Paul Pharoah ; Gabriella Andreotti ; Laura E Beane Freeman ; Stella Koutros ; Demetrius Albanes ; Satu Mannisto ; Stephanie Weinstein ; Peter E. Clark ; Todd E. Edwards ; Loren Lipworth ; Susan M. Gapstur ; Victoria L. Stevens ; Hallie Carol ; Matthew L. Freedman ; Mark M. Pomerantz ; Eunyoung Cho ; Peter Kraft ; Mark A. Preston ; Kathryn M. Wilson ; J Michael Gaziano ; Howard S. Sesso ; Amanda Black ; Neal D. Freedman ; Wen-Yi Huang ; John G. Anema ; Richard J. Kahnoski ; Brian R. Lane ; Sabrina L. Noyes ; David Petillo ; Leandro M. Colli ; Joshua N. Sampson ; Celine Besse ; Helene Blanche ; Anne Boland ; Laurie Burdette ; Egor Prokhortchouk ; Konstantin G. Skryabin ; Meredith Yeager ; Mirjana Mijuskovic ; Miodrag Ognjanovic ; Lenka Foretova ; Ivana Holcatova ; Vladimir Janout ; Dana Mates ; Anush Mukeriya ; Stefan Rascu ; David Zaridze ; Vladimir Bencko ; Cezary Cybulski ; Eleonora Fabianova ; Viorel Jinga ; Jolanta Lissowska ; Jan Lubinski ; Marie Navratilova ; Peter Rudnai ; Neonila Szeszenia-Dabrowska ; Simone Benhamou ; Geraldine Cancel-Tassin ; Olivier Cussenot ; H Bas Bueno-De-Mesquita ; Federico Canzian ; Eric J. Duell ; Börje Ljungberg ; Raviprakash T. Sitaram ; Ulrike Peters ; Emily White ; Garnet L. Anderson ; Lisa Johnson ; Juhua Luo ; Julie Buring ; I-Min Lee ; Wong-Ho Chow ; Lee E. Moore ; Christopher Wood ; Timothy Eisen ; James Larkin ; Toni K. Choueiri ; G Mark Lathrop ; Bin Tean Teh ; Jean-Francois Deleuze ; Xifeng Wu ; Richard S. Houlston ; Paul Brennan ; Stephen J. Chanock ; Ghislaine Scelo ; Mark P. Purdue

Source :

RBID : pubmed:28797570

Abstract

Relative telomere length in peripheral blood leukocytes has been evaluated as a potential biomarker for renal cell carcinoma (RCC) risk in several studies, with conflicting findings.

DOI: 10.1016/j.eururo.2017.07.015
PubMed: 28797570

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pubmed:28797570

Le document en format XML

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<name sortKey="Weinstein, Stephanie" sort="Weinstein, Stephanie" uniqKey="Weinstein S" first="Stephanie" last="Weinstein">Stephanie Weinstein</name>
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<name sortKey="Carol, Hallie" sort="Carol, Hallie" uniqKey="Carol H" first="Hallie" last="Carol">Hallie Carol</name>
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<name sortKey="Freedman, Matthew L" sort="Freedman, Matthew L" uniqKey="Freedman M" first="Matthew L" last="Freedman">Matthew L. Freedman</name>
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<nlm:affiliation>Dana-Farber Cancer Institute, Boston, MA, USA.</nlm:affiliation>
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<name sortKey="Pomerantz, Mark M" sort="Pomerantz, Mark M" uniqKey="Pomerantz M" first="Mark M" last="Pomerantz">Mark M. Pomerantz</name>
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<nlm:affiliation>Dana-Farber Cancer Institute, Boston, MA, USA.</nlm:affiliation>
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<name sortKey="Cho, Eunyoung" sort="Cho, Eunyoung" uniqKey="Cho E" first="Eunyoung" last="Cho">Eunyoung Cho</name>
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<nlm:affiliation>Brown University, Providence, RI, USA.</nlm:affiliation>
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<name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name>
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<nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, MA, USA.</nlm:affiliation>
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<name sortKey="Preston, Mark A" sort="Preston, Mark A" uniqKey="Preston M" first="Mark A" last="Preston">Mark A. Preston</name>
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<nlm:affiliation>Brigham and Women's Hospital, Boston, MA, USA.</nlm:affiliation>
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<name sortKey="Gaziano, J Michael" sort="Gaziano, J Michael" uniqKey="Gaziano J" first="J Michael" last="Gaziano">J Michael Gaziano</name>
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<nlm:affiliation>Brigham and Women's Hospital, Boston, MA, USA; Veterans Administration, Boston, MA, USA.</nlm:affiliation>
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<nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, MA, USA.</nlm:affiliation>
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<name sortKey="Black, Amanda" sort="Black, Amanda" uniqKey="Black A" first="Amanda" last="Black">Amanda Black</name>
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<name sortKey="Freedman, Neal D" sort="Freedman, Neal D" uniqKey="Freedman N" first="Neal D" last="Freedman">Neal D. Freedman</name>
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<nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.</nlm:affiliation>
</affiliation>
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<name sortKey="Huang, Wen Yi" sort="Huang, Wen Yi" uniqKey="Huang W" first="Wen-Yi" last="Huang">Wen-Yi Huang</name>
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<nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.</nlm:affiliation>
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<name sortKey="Anema, John G" sort="Anema, John G" uniqKey="Anema J" first="John G" last="Anema">John G. Anema</name>
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<nlm:affiliation>Division of Urology, Spectrum Health, Grand Rapids, MI, USA.</nlm:affiliation>
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<name sortKey="Kahnoski, Richard J" sort="Kahnoski, Richard J" uniqKey="Kahnoski R" first="Richard J" last="Kahnoski">Richard J. Kahnoski</name>
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<name sortKey="Lane, Brian R" sort="Lane, Brian R" uniqKey="Lane B" first="Brian R" last="Lane">Brian R. Lane</name>
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<name sortKey="Noyes, Sabrina L" sort="Noyes, Sabrina L" uniqKey="Noyes S" first="Sabrina L" last="Noyes">Sabrina L. Noyes</name>
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<nlm:affiliation>Van Andel Research Institute, Center for Cancer Genomics and Quantitative Biology, Grand Rapids, MI, USA.</nlm:affiliation>
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<name sortKey="Petillo, David" sort="Petillo, David" uniqKey="Petillo D" first="David" last="Petillo">David Petillo</name>
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<name sortKey="Colli, Leandro M" sort="Colli, Leandro M" uniqKey="Colli L" first="Leandro M" last="Colli">Leandro M. Colli</name>
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<nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.</nlm:affiliation>
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<name sortKey="Sampson, Joshua N" sort="Sampson, Joshua N" uniqKey="Sampson J" first="Joshua N" last="Sampson">Joshua N. Sampson</name>
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<nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.</nlm:affiliation>
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<name sortKey="Besse, Celine" sort="Besse, Celine" uniqKey="Besse C" first="Celine" last="Besse">Celine Besse</name>
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<nlm:affiliation>Centre National de Recherche en Genomique Humaine (CNRGH), Institut de biologie François Jacob, Commissariat à l'Energie Atomique et aux Energies Alternatives, Evry, France.</nlm:affiliation>
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<name sortKey="Blanche, Helene" sort="Blanche, Helene" uniqKey="Blanche H" first="Helene" last="Blanche">Helene Blanche</name>
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<nlm:affiliation>Fondation Jean Dausset-Centre d'Etude du Polymorphisme Humain, Paris, France.</nlm:affiliation>
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<name sortKey="Boland, Anne" sort="Boland, Anne" uniqKey="Boland A" first="Anne" last="Boland">Anne Boland</name>
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<nlm:affiliation>Centre National de Recherche en Genomique Humaine (CNRGH), Institut de biologie François Jacob, Commissariat à l'Energie Atomique et aux Energies Alternatives, Evry, France.</nlm:affiliation>
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<name sortKey="Burdette, Laurie" sort="Burdette, Laurie" uniqKey="Burdette L" first="Laurie" last="Burdette">Laurie Burdette</name>
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<nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.</nlm:affiliation>
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<name sortKey="Prokhortchouk, Egor" sort="Prokhortchouk, Egor" uniqKey="Prokhortchouk E" first="Egor" last="Prokhortchouk">Egor Prokhortchouk</name>
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<nlm:affiliation>Center 'Bioengineering' of the Russian Academy of Sciences, Moscow, Russian Federation; Kurchatov Scientific Center, Moscow, Russian Federation.</nlm:affiliation>
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<author>
<name sortKey="Skryabin, Konstantin G" sort="Skryabin, Konstantin G" uniqKey="Skryabin K" first="Konstantin G" last="Skryabin">Konstantin G. Skryabin</name>
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<nlm:affiliation>Center 'Bioengineering' of the Russian Academy of Sciences, Moscow, Russian Federation; Kurchatov Scientific Center, Moscow, Russian Federation.</nlm:affiliation>
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<name sortKey="Yeager, Meredith" sort="Yeager, Meredith" uniqKey="Yeager M" first="Meredith" last="Yeager">Meredith Yeager</name>
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<nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Mijuskovic, Mirjana" sort="Mijuskovic, Mirjana" uniqKey="Mijuskovic M" first="Mirjana" last="Mijuskovic">Mirjana Mijuskovic</name>
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<nlm:affiliation>Clinic for Nephrology, Military Medical Academy, Belgrade, Serbia.</nlm:affiliation>
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<author>
<name sortKey="Ognjanovic, Miodrag" sort="Ognjanovic, Miodrag" uniqKey="Ognjanovic M" first="Miodrag" last="Ognjanovic">Miodrag Ognjanovic</name>
<affiliation>
<nlm:affiliation>International Organization for Cancer Prevention and Research (IOCPR), Belgrade, Serbia.</nlm:affiliation>
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</author>
<author>
<name sortKey="Foretova, Lenka" sort="Foretova, Lenka" uniqKey="Foretova L" first="Lenka" last="Foretova">Lenka Foretova</name>
<affiliation>
<nlm:affiliation>International Organization for Cancer Prevention and Research (IOCPR), Belgrade, Serbia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Holcatova, Ivana" sort="Holcatova, Ivana" uniqKey="Holcatova I" first="Ivana" last="Holcatova">Ivana Holcatova</name>
<affiliation>
<nlm:affiliation>Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Janout, Vladimir" sort="Janout, Vladimir" uniqKey="Janout V" first="Vladimir" last="Janout">Vladimir Janout</name>
<affiliation>
<nlm:affiliation>Second Faculty of Medicine, Institute of Public Health and Preventive Medicine, Charles University, Prague, Czech Republic.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Mates, Dana" sort="Mates, Dana" uniqKey="Mates D" first="Dana" last="Mates">Dana Mates</name>
<affiliation>
<nlm:affiliation>Department of Preventive Medicine, Faculty of Medicine, Palacky University, Czech Republic.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Mukeriya, Anush" sort="Mukeriya, Anush" uniqKey="Mukeriya A" first="Anush" last="Mukeriya">Anush Mukeriya</name>
<affiliation>
<nlm:affiliation>National Institute of Public Health, Bucharest, Romania.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Rascu, Stefan" sort="Rascu, Stefan" uniqKey="Rascu S" first="Stefan" last="Rascu">Stefan Rascu</name>
<affiliation>
<nlm:affiliation>Russian N.N. Blokhin Cancer Research Centre, Moscow, Russian Federation.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Zaridze, David" sort="Zaridze, David" uniqKey="Zaridze D" first="David" last="Zaridze">David Zaridze</name>
<affiliation>
<nlm:affiliation>National Institute of Public Health, Bucharest, Romania.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Bencko, Vladimir" sort="Bencko, Vladimir" uniqKey="Bencko V" first="Vladimir" last="Bencko">Vladimir Bencko</name>
<affiliation>
<nlm:affiliation>Carol Davila University of Medicine and Pharmacy, Th. Burghele Hospital, Bucharest, Romania.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Cybulski, Cezary" sort="Cybulski, Cezary" uniqKey="Cybulski C" first="Cezary" last="Cybulski">Cezary Cybulski</name>
<affiliation>
<nlm:affiliation>First Faculty of Medicine, Institute of Hygiene and Epidemiology, Charles University, Prague, Czech Republic.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Fabianova, Eleonora" sort="Fabianova, Eleonora" uniqKey="Fabianova E" first="Eleonora" last="Fabianova">Eleonora Fabianova</name>
<affiliation>
<nlm:affiliation>Regional Authority of Public Health in Banska Bystrica, Banska Bystrica, Slovakia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Jinga, Viorel" sort="Jinga, Viorel" uniqKey="Jinga V" first="Viorel" last="Jinga">Viorel Jinga</name>
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<nlm:affiliation>Carol Davila University of Medicine and Pharmacy, Th. Burghele Hospital, Bucharest, Romania.</nlm:affiliation>
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</author>
<author>
<name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name>
<affiliation>
<nlm:affiliation>The M Sklodowska-Curie Cancer Center and Institute of Oncology, Warsaw, Poland.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name>
<affiliation>
<nlm:affiliation>International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.</nlm:affiliation>
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</author>
<author>
<name sortKey="Navratilova, Marie" sort="Navratilova, Marie" uniqKey="Navratilova M" first="Marie" last="Navratilova">Marie Navratilova</name>
<affiliation>
<nlm:affiliation>Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Rudnai, Peter" sort="Rudnai, Peter" uniqKey="Rudnai P" first="Peter" last="Rudnai">Peter Rudnai</name>
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<nlm:affiliation>National Public Health Center, National Directorate of Environmental Health, Budapest, Hungary.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Szeszenia Dabrowska, Neonila" sort="Szeszenia Dabrowska, Neonila" uniqKey="Szeszenia Dabrowska N" first="Neonila" last="Szeszenia-Dabrowska">Neonila Szeszenia-Dabrowska</name>
<affiliation>
<nlm:affiliation>Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Benhamou, Simone" sort="Benhamou, Simone" uniqKey="Benhamou S" first="Simone" last="Benhamou">Simone Benhamou</name>
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<nlm:affiliation>INSERM U946, Paris, France; CNRS UMR8200, Institute Gustave Roussy, Villejuif, France.</nlm:affiliation>
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</author>
<author>
<name sortKey="Cancel Tassin, Geraldine" sort="Cancel Tassin, Geraldine" uniqKey="Cancel Tassin G" first="Geraldine" last="Cancel-Tassin">Geraldine Cancel-Tassin</name>
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<nlm:affiliation>CeRePP, Paris, France; UPMC Univ Paris 06, Institut Universitaire de Cancérologie, Paris, France.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Cussenot, Olivier" sort="Cussenot, Olivier" uniqKey="Cussenot O" first="Olivier" last="Cussenot">Olivier Cussenot</name>
<affiliation>
<nlm:affiliation>CeRePP, Paris, France; UPMC Univ Paris 06, Institut Universitaire de Cancérologie, Paris, France; AP-HP, Department of Urology, Hopitaux Universitaires Est Parisien Tenon, Paris, France.</nlm:affiliation>
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</author>
<author>
<name sortKey="Bueno De Mesquita, H Bas" sort="Bueno De Mesquita, H Bas" uniqKey="Bueno De Mesquita H" first="H Bas" last="Bueno-De-Mesquita">H Bas Bueno-De-Mesquita</name>
<affiliation>
<nlm:affiliation>Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands; Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands; Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, St Mary's Campus, Norfolk Place, London, UK; Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Pantai Valley, Kuala Lumpur, Malaysia.</nlm:affiliation>
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<name sortKey="Canzian, Federico" sort="Canzian, Federico" uniqKey="Canzian F" first="Federico" last="Canzian">Federico Canzian</name>
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<nlm:affiliation>Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation>
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<author>
<name sortKey="Duell, Eric J" sort="Duell, Eric J" uniqKey="Duell E" first="Eric J" last="Duell">Eric J. Duell</name>
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<nlm:affiliation>Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain.</nlm:affiliation>
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<name sortKey="Ljungberg, Borje" sort="Ljungberg, Borje" uniqKey="Ljungberg B" first="Börje" last="Ljungberg">Börje Ljungberg</name>
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<nlm:affiliation>Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Sitaram, Raviprakash T" sort="Sitaram, Raviprakash T" uniqKey="Sitaram R" first="Raviprakash T" last="Sitaram">Raviprakash T. Sitaram</name>
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<nlm:affiliation>Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name>
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<nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</nlm:affiliation>
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<nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</nlm:affiliation>
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<nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</nlm:affiliation>
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<nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</nlm:affiliation>
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<name sortKey="Luo, Juhua" sort="Luo, Juhua" uniqKey="Luo J" first="Juhua" last="Luo">Juhua Luo</name>
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<nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health Indiana University Bloomington, Bloomington, IN, USA.</nlm:affiliation>
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<name sortKey="Buring, Julie" sort="Buring, Julie" uniqKey="Buring J" first="Julie" last="Buring">Julie Buring</name>
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<nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, MA, USA; Brigham and Women's Hospital, Boston, MA, USA.</nlm:affiliation>
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<nlm:affiliation>Department of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.</nlm:affiliation>
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<nlm:affiliation>University of Cambridge, Cambridge, UK.</nlm:affiliation>
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<nlm:affiliation>Centre National de Recherche en Genomique Humaine (CNRGH), Institut de biologie François Jacob, Commissariat à l'Energie Atomique et aux Energies Alternatives, Evry, France; Fondation Jean Dausset-Centre d'Etude du Polymorphisme Humain, Paris, France.</nlm:affiliation>
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<nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA. Electronic address: purduem@mail.nih.gov.</nlm:affiliation>
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<nlm:affiliation>Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, Australia; Human Genetics Foundation (HuGeF), Torino, Italy; Centre de Recherche en Épidémiologie et Santé des Populations, Université Paris-Saclay, UPS, USQ, Gustave Roussy, Villejuif, France.</nlm:affiliation>
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<nlm:affiliation>Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.</nlm:affiliation>
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<name sortKey="Selby, Peter J" sort="Selby, Peter J" uniqKey="Selby P" first="Peter J" last="Selby">Peter J. Selby</name>
<affiliation>
<nlm:affiliation>Leeds Institute of Cancer and Pathology, University of Leeds, Cancer Research Building, St James's University Hospital, Leeds, UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F" last="Easton">Douglas F. Easton</name>
<affiliation>
<nlm:affiliation>Department of Oncology, and Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Pharoah, Paul" sort="Pharoah, Paul" uniqKey="Pharoah P" first="Paul" last="Pharoah">Paul Pharoah</name>
<affiliation>
<nlm:affiliation>Department of Oncology, and Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Andreotti, Gabriella" sort="Andreotti, Gabriella" uniqKey="Andreotti G" first="Gabriella" last="Andreotti">Gabriella Andreotti</name>
<affiliation>
<nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Freeman, Laura E Beane" sort="Freeman, Laura E Beane" uniqKey="Freeman L" first="Laura E Beane" last="Freeman">Laura E Beane Freeman</name>
<affiliation>
<nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Koutros, Stella" sort="Koutros, Stella" uniqKey="Koutros S" first="Stella" last="Koutros">Stella Koutros</name>
<affiliation>
<nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name>
<affiliation>
<nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Mannisto, Satu" sort="Mannisto, Satu" uniqKey="Mannisto S" first="Satu" last="Mannisto">Satu Mannisto</name>
<affiliation>
<nlm:affiliation>National Institute for Health and Welfare, Helsinki, Finland.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Weinstein, Stephanie" sort="Weinstein, Stephanie" uniqKey="Weinstein S" first="Stephanie" last="Weinstein">Stephanie Weinstein</name>
<affiliation>
<nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Clark, Peter E" sort="Clark, Peter E" uniqKey="Clark P" first="Peter E" last="Clark">Peter E. Clark</name>
<affiliation>
<nlm:affiliation>Vanderbilt-Ingram Cancer Center, Nashville, TN, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Edwards, Todd E" sort="Edwards, Todd E" uniqKey="Edwards T" first="Todd E" last="Edwards">Todd E. Edwards</name>
<affiliation>
<nlm:affiliation>Vanderbilt-Ingram Cancer Center, Nashville, TN, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Lipworth, Loren" sort="Lipworth, Loren" uniqKey="Lipworth L" first="Loren" last="Lipworth">Loren Lipworth</name>
<affiliation>
<nlm:affiliation>Vanderbilt-Ingram Cancer Center, Nashville, TN, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Gapstur, Susan M" sort="Gapstur, Susan M" uniqKey="Gapstur S" first="Susan M" last="Gapstur">Susan M. Gapstur</name>
<affiliation>
<nlm:affiliation>American Cancer Society, Atlanta, GA, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Stevens, Victoria L" sort="Stevens, Victoria L" uniqKey="Stevens V" first="Victoria L" last="Stevens">Victoria L. Stevens</name>
<affiliation>
<nlm:affiliation>American Cancer Society, Atlanta, GA, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Carol, Hallie" sort="Carol, Hallie" uniqKey="Carol H" first="Hallie" last="Carol">Hallie Carol</name>
<affiliation>
<nlm:affiliation>Dana-Farber Cancer Institute, Boston, MA, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Freedman, Matthew L" sort="Freedman, Matthew L" uniqKey="Freedman M" first="Matthew L" last="Freedman">Matthew L. Freedman</name>
<affiliation>
<nlm:affiliation>Dana-Farber Cancer Institute, Boston, MA, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Pomerantz, Mark M" sort="Pomerantz, Mark M" uniqKey="Pomerantz M" first="Mark M" last="Pomerantz">Mark M. Pomerantz</name>
<affiliation>
<nlm:affiliation>Dana-Farber Cancer Institute, Boston, MA, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Cho, Eunyoung" sort="Cho, Eunyoung" uniqKey="Cho E" first="Eunyoung" last="Cho">Eunyoung Cho</name>
<affiliation>
<nlm:affiliation>Brown University, Providence, RI, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name>
<affiliation>
<nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, MA, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Preston, Mark A" sort="Preston, Mark A" uniqKey="Preston M" first="Mark A" last="Preston">Mark A. Preston</name>
<affiliation>
<nlm:affiliation>Brigham and Women's Hospital, Boston, MA, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Wilson, Kathryn M" sort="Wilson, Kathryn M" uniqKey="Wilson K" first="Kathryn M" last="Wilson">Kathryn M. Wilson</name>
<affiliation>
<nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, MA, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Gaziano, J Michael" sort="Gaziano, J Michael" uniqKey="Gaziano J" first="J Michael" last="Gaziano">J Michael Gaziano</name>
<affiliation>
<nlm:affiliation>Brigham and Women's Hospital, Boston, MA, USA; Veterans Administration, Boston, MA, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Sesso, Howard S" sort="Sesso, Howard S" uniqKey="Sesso H" first="Howard S" last="Sesso">Howard S. Sesso</name>
<affiliation>
<nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, MA, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Black, Amanda" sort="Black, Amanda" uniqKey="Black A" first="Amanda" last="Black">Amanda Black</name>
<affiliation>
<nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Freedman, Neal D" sort="Freedman, Neal D" uniqKey="Freedman N" first="Neal D" last="Freedman">Neal D. Freedman</name>
<affiliation>
<nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Huang, Wen Yi" sort="Huang, Wen Yi" uniqKey="Huang W" first="Wen-Yi" last="Huang">Wen-Yi Huang</name>
<affiliation>
<nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Anema, John G" sort="Anema, John G" uniqKey="Anema J" first="John G" last="Anema">John G. Anema</name>
<affiliation>
<nlm:affiliation>Division of Urology, Spectrum Health, Grand Rapids, MI, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Kahnoski, Richard J" sort="Kahnoski, Richard J" uniqKey="Kahnoski R" first="Richard J" last="Kahnoski">Richard J. Kahnoski</name>
<affiliation>
<nlm:affiliation>Division of Urology, Spectrum Health, Grand Rapids, MI, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Lane, Brian R" sort="Lane, Brian R" uniqKey="Lane B" first="Brian R" last="Lane">Brian R. Lane</name>
<affiliation>
<nlm:affiliation>Division of Urology, Spectrum Health, Grand Rapids, MI, USA; College of Human Medicine, Michigan State University, Grand Rapids, MI, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Noyes, Sabrina L" sort="Noyes, Sabrina L" uniqKey="Noyes S" first="Sabrina L" last="Noyes">Sabrina L. Noyes</name>
<affiliation>
<nlm:affiliation>Van Andel Research Institute, Center for Cancer Genomics and Quantitative Biology, Grand Rapids, MI, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Petillo, David" sort="Petillo, David" uniqKey="Petillo D" first="David" last="Petillo">David Petillo</name>
<affiliation>
<nlm:affiliation>Van Andel Research Institute, Center for Cancer Genomics and Quantitative Biology, Grand Rapids, MI, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Colli, Leandro M" sort="Colli, Leandro M" uniqKey="Colli L" first="Leandro M" last="Colli">Leandro M. Colli</name>
<affiliation>
<nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Sampson, Joshua N" sort="Sampson, Joshua N" uniqKey="Sampson J" first="Joshua N" last="Sampson">Joshua N. Sampson</name>
<affiliation>
<nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Besse, Celine" sort="Besse, Celine" uniqKey="Besse C" first="Celine" last="Besse">Celine Besse</name>
<affiliation>
<nlm:affiliation>Centre National de Recherche en Genomique Humaine (CNRGH), Institut de biologie François Jacob, Commissariat à l'Energie Atomique et aux Energies Alternatives, Evry, France.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Blanche, Helene" sort="Blanche, Helene" uniqKey="Blanche H" first="Helene" last="Blanche">Helene Blanche</name>
<affiliation>
<nlm:affiliation>Fondation Jean Dausset-Centre d'Etude du Polymorphisme Humain, Paris, France.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Boland, Anne" sort="Boland, Anne" uniqKey="Boland A" first="Anne" last="Boland">Anne Boland</name>
<affiliation>
<nlm:affiliation>Centre National de Recherche en Genomique Humaine (CNRGH), Institut de biologie François Jacob, Commissariat à l'Energie Atomique et aux Energies Alternatives, Evry, France.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Burdette, Laurie" sort="Burdette, Laurie" uniqKey="Burdette L" first="Laurie" last="Burdette">Laurie Burdette</name>
<affiliation>
<nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Prokhortchouk, Egor" sort="Prokhortchouk, Egor" uniqKey="Prokhortchouk E" first="Egor" last="Prokhortchouk">Egor Prokhortchouk</name>
<affiliation>
<nlm:affiliation>Center 'Bioengineering' of the Russian Academy of Sciences, Moscow, Russian Federation; Kurchatov Scientific Center, Moscow, Russian Federation.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Skryabin, Konstantin G" sort="Skryabin, Konstantin G" uniqKey="Skryabin K" first="Konstantin G" last="Skryabin">Konstantin G. Skryabin</name>
<affiliation>
<nlm:affiliation>Center 'Bioengineering' of the Russian Academy of Sciences, Moscow, Russian Federation; Kurchatov Scientific Center, Moscow, Russian Federation.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Yeager, Meredith" sort="Yeager, Meredith" uniqKey="Yeager M" first="Meredith" last="Yeager">Meredith Yeager</name>
<affiliation>
<nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Mijuskovic, Mirjana" sort="Mijuskovic, Mirjana" uniqKey="Mijuskovic M" first="Mirjana" last="Mijuskovic">Mirjana Mijuskovic</name>
<affiliation>
<nlm:affiliation>Clinic for Nephrology, Military Medical Academy, Belgrade, Serbia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Ognjanovic, Miodrag" sort="Ognjanovic, Miodrag" uniqKey="Ognjanovic M" first="Miodrag" last="Ognjanovic">Miodrag Ognjanovic</name>
<affiliation>
<nlm:affiliation>International Organization for Cancer Prevention and Research (IOCPR), Belgrade, Serbia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Foretova, Lenka" sort="Foretova, Lenka" uniqKey="Foretova L" first="Lenka" last="Foretova">Lenka Foretova</name>
<affiliation>
<nlm:affiliation>International Organization for Cancer Prevention and Research (IOCPR), Belgrade, Serbia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Holcatova, Ivana" sort="Holcatova, Ivana" uniqKey="Holcatova I" first="Ivana" last="Holcatova">Ivana Holcatova</name>
<affiliation>
<nlm:affiliation>Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Janout, Vladimir" sort="Janout, Vladimir" uniqKey="Janout V" first="Vladimir" last="Janout">Vladimir Janout</name>
<affiliation>
<nlm:affiliation>Second Faculty of Medicine, Institute of Public Health and Preventive Medicine, Charles University, Prague, Czech Republic.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Mates, Dana" sort="Mates, Dana" uniqKey="Mates D" first="Dana" last="Mates">Dana Mates</name>
<affiliation>
<nlm:affiliation>Department of Preventive Medicine, Faculty of Medicine, Palacky University, Czech Republic.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Mukeriya, Anush" sort="Mukeriya, Anush" uniqKey="Mukeriya A" first="Anush" last="Mukeriya">Anush Mukeriya</name>
<affiliation>
<nlm:affiliation>National Institute of Public Health, Bucharest, Romania.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Rascu, Stefan" sort="Rascu, Stefan" uniqKey="Rascu S" first="Stefan" last="Rascu">Stefan Rascu</name>
<affiliation>
<nlm:affiliation>Russian N.N. Blokhin Cancer Research Centre, Moscow, Russian Federation.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Zaridze, David" sort="Zaridze, David" uniqKey="Zaridze D" first="David" last="Zaridze">David Zaridze</name>
<affiliation>
<nlm:affiliation>National Institute of Public Health, Bucharest, Romania.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Bencko, Vladimir" sort="Bencko, Vladimir" uniqKey="Bencko V" first="Vladimir" last="Bencko">Vladimir Bencko</name>
<affiliation>
<nlm:affiliation>Carol Davila University of Medicine and Pharmacy, Th. Burghele Hospital, Bucharest, Romania.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Cybulski, Cezary" sort="Cybulski, Cezary" uniqKey="Cybulski C" first="Cezary" last="Cybulski">Cezary Cybulski</name>
<affiliation>
<nlm:affiliation>First Faculty of Medicine, Institute of Hygiene and Epidemiology, Charles University, Prague, Czech Republic.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Fabianova, Eleonora" sort="Fabianova, Eleonora" uniqKey="Fabianova E" first="Eleonora" last="Fabianova">Eleonora Fabianova</name>
<affiliation>
<nlm:affiliation>Regional Authority of Public Health in Banska Bystrica, Banska Bystrica, Slovakia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Jinga, Viorel" sort="Jinga, Viorel" uniqKey="Jinga V" first="Viorel" last="Jinga">Viorel Jinga</name>
<affiliation>
<nlm:affiliation>Carol Davila University of Medicine and Pharmacy, Th. Burghele Hospital, Bucharest, Romania.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name>
<affiliation>
<nlm:affiliation>The M Sklodowska-Curie Cancer Center and Institute of Oncology, Warsaw, Poland.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name>
<affiliation>
<nlm:affiliation>International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Navratilova, Marie" sort="Navratilova, Marie" uniqKey="Navratilova M" first="Marie" last="Navratilova">Marie Navratilova</name>
<affiliation>
<nlm:affiliation>Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Rudnai, Peter" sort="Rudnai, Peter" uniqKey="Rudnai P" first="Peter" last="Rudnai">Peter Rudnai</name>
<affiliation>
<nlm:affiliation>National Public Health Center, National Directorate of Environmental Health, Budapest, Hungary.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Szeszenia Dabrowska, Neonila" sort="Szeszenia Dabrowska, Neonila" uniqKey="Szeszenia Dabrowska N" first="Neonila" last="Szeszenia-Dabrowska">Neonila Szeszenia-Dabrowska</name>
<affiliation>
<nlm:affiliation>Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Benhamou, Simone" sort="Benhamou, Simone" uniqKey="Benhamou S" first="Simone" last="Benhamou">Simone Benhamou</name>
<affiliation>
<nlm:affiliation>INSERM U946, Paris, France; CNRS UMR8200, Institute Gustave Roussy, Villejuif, France.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Cancel Tassin, Geraldine" sort="Cancel Tassin, Geraldine" uniqKey="Cancel Tassin G" first="Geraldine" last="Cancel-Tassin">Geraldine Cancel-Tassin</name>
<affiliation>
<nlm:affiliation>CeRePP, Paris, France; UPMC Univ Paris 06, Institut Universitaire de Cancérologie, Paris, France.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Cussenot, Olivier" sort="Cussenot, Olivier" uniqKey="Cussenot O" first="Olivier" last="Cussenot">Olivier Cussenot</name>
<affiliation>
<nlm:affiliation>CeRePP, Paris, France; UPMC Univ Paris 06, Institut Universitaire de Cancérologie, Paris, France; AP-HP, Department of Urology, Hopitaux Universitaires Est Parisien Tenon, Paris, France.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Bueno De Mesquita, H Bas" sort="Bueno De Mesquita, H Bas" uniqKey="Bueno De Mesquita H" first="H Bas" last="Bueno-De-Mesquita">H Bas Bueno-De-Mesquita</name>
<affiliation>
<nlm:affiliation>Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands; Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands; Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, St Mary's Campus, Norfolk Place, London, UK; Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Pantai Valley, Kuala Lumpur, Malaysia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Canzian, Federico" sort="Canzian, Federico" uniqKey="Canzian F" first="Federico" last="Canzian">Federico Canzian</name>
<affiliation>
<nlm:affiliation>Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Duell, Eric J" sort="Duell, Eric J" uniqKey="Duell E" first="Eric J" last="Duell">Eric J. Duell</name>
<affiliation>
<nlm:affiliation>Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Ljungberg, Borje" sort="Ljungberg, Borje" uniqKey="Ljungberg B" first="Börje" last="Ljungberg">Börje Ljungberg</name>
<affiliation>
<nlm:affiliation>Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Sitaram, Raviprakash T" sort="Sitaram, Raviprakash T" uniqKey="Sitaram R" first="Raviprakash T" last="Sitaram">Raviprakash T. Sitaram</name>
<affiliation>
<nlm:affiliation>Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name>
<affiliation>
<nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name>
<affiliation>
<nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Anderson, Garnet L" sort="Anderson, Garnet L" uniqKey="Anderson G" first="Garnet L" last="Anderson">Garnet L. Anderson</name>
<affiliation>
<nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Johnson, Lisa" sort="Johnson, Lisa" uniqKey="Johnson L" first="Lisa" last="Johnson">Lisa Johnson</name>
<affiliation>
<nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Luo, Juhua" sort="Luo, Juhua" uniqKey="Luo J" first="Juhua" last="Luo">Juhua Luo</name>
<affiliation>
<nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health Indiana University Bloomington, Bloomington, IN, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Buring, Julie" sort="Buring, Julie" uniqKey="Buring J" first="Julie" last="Buring">Julie Buring</name>
<affiliation>
<nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, MA, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Lee, I Min" sort="Lee, I Min" uniqKey="Lee I" first="I-Min" last="Lee">I-Min Lee</name>
<affiliation>
<nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, MA, USA; Brigham and Women's Hospital, Boston, MA, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Chow, Wong Ho" sort="Chow, Wong Ho" uniqKey="Chow W" first="Wong-Ho" last="Chow">Wong-Ho Chow</name>
<affiliation>
<nlm:affiliation>Department of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Moore, Lee E" sort="Moore, Lee E" uniqKey="Moore L" first="Lee E" last="Moore">Lee E. Moore</name>
<affiliation>
<nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Wood, Christopher" sort="Wood, Christopher" uniqKey="Wood C" first="Christopher" last="Wood">Christopher Wood</name>
<affiliation>
<nlm:affiliation>Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Eisen, Timothy" sort="Eisen, Timothy" uniqKey="Eisen T" first="Timothy" last="Eisen">Timothy Eisen</name>
<affiliation>
<nlm:affiliation>University of Cambridge, Cambridge, UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Larkin, James" sort="Larkin, James" uniqKey="Larkin J" first="James" last="Larkin">James Larkin</name>
<affiliation>
<nlm:affiliation>Royal Marsden NHS Foundation Trust, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Choueiri, Toni K" sort="Choueiri, Toni K" uniqKey="Choueiri T" first="Toni K" last="Choueiri">Toni K. Choueiri</name>
<affiliation>
<nlm:affiliation>Dana-Farber Cancer Institute, Boston, MA, USA.</nlm:affiliation>
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</author>
<author>
<name sortKey="Lathrop, G Mark" sort="Lathrop, G Mark" uniqKey="Lathrop G" first="G Mark" last="Lathrop">G Mark Lathrop</name>
<affiliation>
<nlm:affiliation>McGill University and Genome Quebec Innovation Centre, Montreal, QC, Canada.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Teh, Bin Tean" sort="Teh, Bin Tean" uniqKey="Teh B" first="Bin Tean" last="Teh">Bin Tean Teh</name>
<affiliation>
<nlm:affiliation>Van Andel Research Institute, Center for Cancer Genomics and Quantitative Biology, Grand Rapids, MI, USA.</nlm:affiliation>
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</author>
<author>
<name sortKey="Deleuze, Jean Francois" sort="Deleuze, Jean Francois" uniqKey="Deleuze J" first="Jean-Francois" last="Deleuze">Jean-Francois Deleuze</name>
<affiliation>
<nlm:affiliation>Centre National de Recherche en Genomique Humaine (CNRGH), Institut de biologie François Jacob, Commissariat à l'Energie Atomique et aux Energies Alternatives, Evry, France; Fondation Jean Dausset-Centre d'Etude du Polymorphisme Humain, Paris, France.</nlm:affiliation>
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</author>
<author>
<name sortKey="Wu, Xifeng" sort="Wu, Xifeng" uniqKey="Wu X" first="Xifeng" last="Wu">Xifeng Wu</name>
<affiliation>
<nlm:affiliation>Department of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Houlston, Richard S" sort="Houlston, Richard S" uniqKey="Houlston R" first="Richard S" last="Houlston">Richard S. Houlston</name>
<affiliation>
<nlm:affiliation>The Institute of Cancer Research, London, UK.</nlm:affiliation>
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</author>
<author>
<name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name>
<affiliation>
<nlm:affiliation>International Agency for Research on Cancer (IARC), Lyon, France.</nlm:affiliation>
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<author>
<name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J" last="Chanock">Stephen J. Chanock</name>
<affiliation>
<nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Scelo, Ghislaine" sort="Scelo, Ghislaine" uniqKey="Scelo G" first="Ghislaine" last="Scelo">Ghislaine Scelo</name>
<affiliation>
<nlm:affiliation>International Agency for Research on Cancer (IARC), Lyon, France.</nlm:affiliation>
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</author>
<author>
<name sortKey="Purdue, Mark P" sort="Purdue, Mark P" uniqKey="Purdue M" first="Mark P" last="Purdue">Mark P. Purdue</name>
<affiliation>
<nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA. Electronic address: purduem@mail.nih.gov.</nlm:affiliation>
</affiliation>
</author>
</analytic>
<series>
<title level="j">European urology</title>
<idno type="eISSN">1873-7560</idno>
<imprint>
<date when="2017" type="published">2017</date>
</imprint>
</series>
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<front>
<div type="abstract" xml:lang="en">Relative telomere length in peripheral blood leukocytes has been evaluated as a potential biomarker for renal cell carcinoma (RCC) risk in several studies, with conflicting findings.</div>
</front>
</TEI>
<pubmed>
<MedlineCitation Status="In-Process" Owner="NLM">
<PMID Version="1">28797570</PMID>
<DateCreated>
<Year>2017</Year>
<Month>08</Month>
<Day>11</Day>
</DateCreated>
<DateRevised>
<Year>2017</Year>
<Month>10</Month>
<Day>24</Day>
</DateRevised>
<Article PubModel="Print-Electronic">
<Journal>
<ISSN IssnType="Electronic">1873-7560</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>72</Volume>
<Issue>5</Issue>
<PubDate>
<Year>2017</Year>
<Month>Nov</Month>
</PubDate>
</JournalIssue>
<Title>European urology</Title>
<ISOAbbreviation>Eur. Urol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Genetic Variants Related to Longer Telomere Length are Associated with Increased Risk of Renal Cell Carcinoma.</ArticleTitle>
<Pagination>
<MedlinePgn>747-754</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S0302-2838(17)30639-5</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.eururo.2017.07.015</ELocationID>
<Abstract>
<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Relative telomere length in peripheral blood leukocytes has been evaluated as a potential biomarker for renal cell carcinoma (RCC) risk in several studies, with conflicting findings.</AbstractText>
<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">We performed an analysis of genetic variants associated with leukocyte telomere length to assess the relationship between telomere length and RCC risk using Mendelian randomization, an approach unaffected by biases from temporal variability and reverse causation that might have affected earlier investigations.</AbstractText>
<AbstractText Label="DESIGN, SETTING, AND PARTICIPANTS" NlmCategory="METHODS">Genotypes from nine telomere length-associated variants for 10 784 cases and 20 406 cancer-free controls from six genome-wide association studies (GWAS) of RCC were aggregated into a weighted genetic risk score (GRS) predictive of leukocyte telomere length.</AbstractText>
<AbstractText Label="OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS" NlmCategory="UNASSIGNED">Odds ratios (ORs) relating the GRS and RCC risk were computed in individual GWAS datasets and combined by meta-analysis.</AbstractText>
<AbstractText Label="RESULTS AND LIMITATIONS" NlmCategory="CONCLUSIONS">Longer genetically inferred telomere length was associated with an increased risk of RCC (OR=2.07 per predicted kilobase increase, 95% confidence interval [CI]:=1.70-2.53, p<0.0001). As a sensitivity analysis, we excluded two telomere length variants in linkage disequilibrium (R(2)>0.5) with GWAS-identified RCC risk variants (rs10936599 and rs9420907) from the telomere length GRS; despite this exclusion, a statistically significant association between the GRS and RCC risk persisted (OR=1.73, 95% CI=1.36-2.21, p<0.0001). Exploratory analyses for individual histologic subtypes suggested comparable associations with the telomere length GRS for clear cell (N=5573, OR=1.93, 95% CI=1.50-2.49, p<0.0001), papillary (N=573, OR=1.96, 95% CI=1.01-3.81, p=0.046), and chromophobe RCC (N=203, OR=2.37, 95% CI=0.78-7.17, p=0.13).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our investigation adds to the growing body of evidence indicating some aspect of longer telomere length is important for RCC risk.</AbstractText>
<AbstractText Label="PATIENT SUMMARY" NlmCategory="UNASSIGNED">Telomeres are segments of DNA at chromosome ends that maintain chromosomal stability. Our study investigated the relationship between genetic variants associated with telomere length and renal cell carcinoma risk. We found evidence suggesting individuals with inherited predisposition to longer telomere length are at increased risk of developing renal cell carcinoma.</AbstractText>
<CopyrightInformation>Published by Elsevier B.V.</CopyrightInformation>
</Abstract>
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<LastName>Machiela</LastName>
<ForeName>Mitchell J</ForeName>
<Initials>MJ</Initials>
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<Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.</Affiliation>
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</Author>
<Author ValidYN="Y">
<LastName>Hofmann</LastName>
<ForeName>Jonathan N</ForeName>
<Initials>JN</Initials>
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<LastName>Carreras-Torres</LastName>
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<Initials>KM</Initials>
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<ForeName>Zhaoming</ForeName>
<Initials>Z</Initials>
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<LastName>Savage</LastName>
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<Affiliation>QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia; School of Public Health, The University of Queensland, Brisbane, Australia.</Affiliation>
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<CommentsCorrections RefType="Cites">
<RefSource>Hum Mol Genet. 2015 Sep 15;24(18):5356-66</RefSource>
<PMID Version="1">26138067</PMID>
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<Keyword MajorTopicYN="N">Genetic variants</Keyword>
<Keyword MajorTopicYN="N">Mendelian randomization</Keyword>
<Keyword MajorTopicYN="N">Renal cell carcinoma</Keyword>
<Keyword MajorTopicYN="N">Risk</Keyword>
<Keyword MajorTopicYN="N">Telomere length</Keyword>
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<Month>07</Month>
<Day>17</Day>
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<ArticleId IdType="doi">10.1016/j.eururo.2017.07.015</ArticleId>
<ArticleId IdType="pmc">PMC5641242</ArticleId>
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