Evidence of Heritable Determinants of Decompression Sickness in Rats.
Identifieur interne : 000101 ( PubMed/Corpus ); précédent : 000100; suivant : 000102Evidence of Heritable Determinants of Decompression Sickness in Rats.
Auteurs : Jacky Lautridou ; Peter Buzzacott ; Marc Belhomme ; Emmanuel Dugrenot ; Pierre Lafère ; Costantino Balestra ; François GuerreroSource :
- Medicine and science in sports and exercise [ 1530-0315 ] ; 2017.
Abstract
Decompression sickness (DCS) is a complex and poorly understood systemic disease caused by inadequate desaturation after a decrease of ambient pressure. Strong variability between individuals is observed for DCS occurrence. This raises questions concerning factors that may be involved in the interindividual variability of DCS occurrence. This study aimed to experimentally assess the existence of heritable factors involved in DCS occurrence by selectively breeding individuals resistant to DCS from a population stock of Wistar rats.
DOI: 10.1249/MSS.0000000000001385
PubMed: 28731987
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Evidence of Heritable Determinants of Decompression Sickness in Rats.</title><author><name sortKey="Lautridou, Jacky" sort="Lautridou, Jacky" uniqKey="Lautridou J" first="Jacky" last="Lautridou">Jacky Lautridou</name><affiliation><nlm:affiliation>1University of Western Brittany, IBSAM, Brest, FRANCE; 2School of Sports Science, Exercise and Health, University of Western Australia, Crawley, AUSTRALIA; and 3Environmental & Occupational Physiology Laboratory, (ISEK), Haute Ecole Bruxelles-Brabant (HE2B), Brussels, BELGIUM.</nlm:affiliation></affiliation></author><author><name sortKey="Buzzacott, Peter" sort="Buzzacott, Peter" uniqKey="Buzzacott P" first="Peter" last="Buzzacott">Peter Buzzacott</name></author><author><name sortKey="Belhomme, Marc" sort="Belhomme, Marc" uniqKey="Belhomme M" first="Marc" last="Belhomme">Marc Belhomme</name></author><author><name sortKey="Dugrenot, Emmanuel" sort="Dugrenot, Emmanuel" uniqKey="Dugrenot E" first="Emmanuel" last="Dugrenot">Emmanuel Dugrenot</name></author><author><name sortKey="Lafere, Pierre" sort="Lafere, Pierre" uniqKey="Lafere P" first="Pierre" last="Lafère">Pierre Lafère</name></author><author><name sortKey="Balestra, Costantino" sort="Balestra, Costantino" uniqKey="Balestra C" first="Costantino" last="Balestra">Costantino Balestra</name></author><author><name sortKey="Guerrero, Francois" sort="Guerrero, Francois" uniqKey="Guerrero F" first="François" last="Guerrero">François Guerrero</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28731987</idno><idno type="pmid">28731987</idno><idno type="doi">10.1249/MSS.0000000000001385</idno><idno type="wicri:Area/PubMed/Corpus">000101</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000101</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Evidence of Heritable Determinants of Decompression Sickness in Rats.</title><author><name sortKey="Lautridou, Jacky" sort="Lautridou, Jacky" uniqKey="Lautridou J" first="Jacky" last="Lautridou">Jacky Lautridou</name><affiliation><nlm:affiliation>1University of Western Brittany, IBSAM, Brest, FRANCE; 2School of Sports Science, Exercise and Health, University of Western Australia, Crawley, AUSTRALIA; and 3Environmental & Occupational Physiology Laboratory, (ISEK), Haute Ecole Bruxelles-Brabant (HE2B), Brussels, BELGIUM.</nlm:affiliation></affiliation></author><author><name sortKey="Buzzacott, Peter" sort="Buzzacott, Peter" uniqKey="Buzzacott P" first="Peter" last="Buzzacott">Peter Buzzacott</name></author><author><name sortKey="Belhomme, Marc" sort="Belhomme, Marc" uniqKey="Belhomme M" first="Marc" last="Belhomme">Marc Belhomme</name></author><author><name sortKey="Dugrenot, Emmanuel" sort="Dugrenot, Emmanuel" uniqKey="Dugrenot E" first="Emmanuel" last="Dugrenot">Emmanuel Dugrenot</name></author><author><name sortKey="Lafere, Pierre" sort="Lafere, Pierre" uniqKey="Lafere P" first="Pierre" last="Lafère">Pierre Lafère</name></author><author><name sortKey="Balestra, Costantino" sort="Balestra, Costantino" uniqKey="Balestra C" first="Costantino" last="Balestra">Costantino Balestra</name></author><author><name sortKey="Guerrero, Francois" sort="Guerrero, Francois" uniqKey="Guerrero F" first="François" last="Guerrero">François Guerrero</name></author></analytic><series><title level="j">Medicine and science in sports and exercise</title><idno type="eISSN">1530-0315</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Decompression sickness (DCS) is a complex and poorly understood systemic disease caused by inadequate desaturation after a decrease of ambient pressure. Strong variability between individuals is observed for DCS occurrence. This raises questions concerning factors that may be involved in the interindividual variability of DCS occurrence. This study aimed to experimentally assess the existence of heritable factors involved in DCS occurrence by selectively breeding individuals resistant to DCS from a population stock of Wistar rats.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28731987</PMID><DateCreated><Year>2017</Year><Month>07</Month><Day>21</Day></DateCreated><DateRevised><Year>2017</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1530-0315</ISSN><JournalIssue CitedMedium="Internet"><Volume>49</Volume><Issue>12</Issue><PubDate><Year>2017</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Medicine and science in sports and exercise</Title><ISOAbbreviation>Med Sci Sports Exerc</ISOAbbreviation></Journal><ArticleTitle>Evidence of Heritable Determinants of Decompression Sickness in Rats.</ArticleTitle><Pagination><MedlinePgn>2433-2438</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1249/MSS.0000000000001385</ELocationID><Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">Decompression sickness (DCS) is a complex and poorly understood systemic disease caused by inadequate desaturation after a decrease of ambient pressure. Strong variability between individuals is observed for DCS occurrence. This raises questions concerning factors that may be involved in the interindividual variability of DCS occurrence. This study aimed to experimentally assess the existence of heritable factors involved in DCS occurrence by selectively breeding individuals resistant to DCS from a population stock of Wistar rats.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Fifty-two male and 52 female Wistar rats were submitted to a simulated air dive known to reliably induce about 63% DCS: compression was performed at 100 kPa·min up to 1000 kPa absolute pressure before a 45-min long stay. Decompression was performed at 100 kPa·min with three decompression stops: 5 min at 200 kPa, 5 min at 160 kPa, and 10 min at 130 kPa. Animals were observed for 1 h to detect DCS symptoms. Individuals without DCS were selected and bred to create a new generation, subsequently subjected to the same hyperbaric protocol. This procedure was repeated up to the third generation of rats.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">As reported previously, this diving profile induced 67% of DCS, and 33% asymptomatic animals in the founding population. DCS/asymptomatic ratio was not initially different between sexes, although males were heavier than females. In three generations, the outcome of the dive significantly changed from 33% to 67% asymptomatic rats, for both sexes. Interestingly, survival in females increased sooner than in males.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">This study offers evidence suggesting the inheritance of DCS resistance. Future research will focus on genetic and physiological comparisons between the initial strain and the new resistant population.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lautridou</LastName><ForeName>Jacky</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>1University of Western Brittany, IBSAM, Brest, FRANCE; 2School of Sports Science, Exercise and Health, University of Western Australia, Crawley, AUSTRALIA; and 3Environmental & Occupational Physiology Laboratory, (ISEK), Haute Ecole Bruxelles-Brabant (HE2B), Brussels, BELGIUM.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Buzzacott</LastName><ForeName>Peter</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Belhomme</LastName><ForeName>Marc</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Dugrenot</LastName><ForeName>Emmanuel</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Lafère</LastName><ForeName>Pierre</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Balestra</LastName><ForeName>Costantino</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Guerrero</LastName><ForeName>François</ForeName><Initials>F</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Med Sci Sports Exerc</MedlineTA><NlmUniqueID>8005433</NlmUniqueID><ISSNLinking>0195-9131</ISSNLinking></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>7</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>7</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>7</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28731987</ArticleId><ArticleId IdType="doi">10.1249/MSS.0000000000001385</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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