Evidence for an important role of host microRNAs in regulating hepatic fibrosis in humans infected with Schistosoma japonicum.
Identifieur interne : 000099 ( PubMed/Corpus ); précédent : 000098; suivant : 000100Evidence for an important role of host microRNAs in regulating hepatic fibrosis in humans infected with Schistosoma japonicum.
Auteurs : Sandrine Cabantous ; Xunya Hou ; Laurence Louis ; Hongbin He ; Odette Mariani ; Xavier Sastre ; Martine Daujat-Chavanieu ; Yuesheng Li ; Alain DesseinSource :
- International journal for parasitology [ 1879-0135 ] ; 2017.
Abstract
MicroRNAs (miRNAs) are short, non-coding RNAs that repress the translation of target gene transcripts. They have been implicated in various activities such as cell proliferation, survival, differentiation, migration and metabolism. We report here the first known miRNome and transcriptome analysis of human livers displaying advanced fibrosis due to Schistosoma japonicum infection. We present evidence that hsa-miR-150-5p, hsa-miR-10a-5p, hsa-miR-199a-3p, hsa-miR-4521, hsa-miR-222/221, hsa-miR-663b and hsa-miR-143-3p (associated without correction) play an important role in hepatic fibrosis by acting on metabolism, organization of the extracellular matrix proteins, lipid mobilization and limitation of oxidative damage stress.
DOI: 10.1016/j.ijpara.2017.05.007
PubMed: 28739251
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Electronic address: sandrine.ambard@univ-amu.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Hou, Xunya" sort="Hou, Xunya" uniqKey="Hou X" first="Xunya" last="Hou">Xunya Hou</name><affiliation><nlm:affiliation>Hunan Institute of Parasitic Diseases, Yueyang, China.</nlm:affiliation></affiliation></author><author><name sortKey="Louis, Laurence" sort="Louis, Laurence" uniqKey="Louis L" first="Laurence" last="Louis">Laurence Louis</name><affiliation><nlm:affiliation>INSERM UMR910, GMGF, Aix Marseille Université, 13005 Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="He, Hongbin" sort="He, Hongbin" uniqKey="He H" first="Hongbin" last="He">Hongbin He</name><affiliation><nlm:affiliation>Hunan Institute of Parasitic Diseases, Yueyang, China.</nlm:affiliation></affiliation></author><author><name sortKey="Mariani, Odette" sort="Mariani, Odette" uniqKey="Mariani O" first="Odette" last="Mariani">Odette Mariani</name><affiliation><nlm:affiliation>Institut Curie, Section Médicale, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Sastre, Xavier" sort="Sastre, Xavier" uniqKey="Sastre X" first="Xavier" last="Sastre">Xavier Sastre</name><affiliation><nlm:affiliation>Institut Curie, Section Médicale, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Daujat Chavanieu, Martine" sort="Daujat Chavanieu, Martine" uniqKey="Daujat Chavanieu M" first="Martine" last="Daujat-Chavanieu">Martine Daujat-Chavanieu</name><affiliation><nlm:affiliation>INSERM U1040, Hôpital St Eloi, Montpellier, France.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Yuesheng" sort="Li, Yuesheng" uniqKey="Li Y" first="Yuesheng" last="Li">Yuesheng Li</name><affiliation><nlm:affiliation>Queensland Institute of Medical Research, Brisbane, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Dessein, Alain" sort="Dessein, Alain" uniqKey="Dessein A" first="Alain" last="Dessein">Alain Dessein</name><affiliation><nlm:affiliation>Institut National de la Santé et de la Recherche Médicale (INSERM), UMR906, GIMP, Labex ParaFrap, Aix-Marseille Université, 13005 Marseille, France. 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Electronic address: sandrine.ambard@univ-amu.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Hou, Xunya" sort="Hou, Xunya" uniqKey="Hou X" first="Xunya" last="Hou">Xunya Hou</name><affiliation><nlm:affiliation>Hunan Institute of Parasitic Diseases, Yueyang, China.</nlm:affiliation></affiliation></author><author><name sortKey="Louis, Laurence" sort="Louis, Laurence" uniqKey="Louis L" first="Laurence" last="Louis">Laurence Louis</name><affiliation><nlm:affiliation>INSERM UMR910, GMGF, Aix Marseille Université, 13005 Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="He, Hongbin" sort="He, Hongbin" uniqKey="He H" first="Hongbin" last="He">Hongbin He</name><affiliation><nlm:affiliation>Hunan Institute of Parasitic Diseases, Yueyang, China.</nlm:affiliation></affiliation></author><author><name sortKey="Mariani, Odette" sort="Mariani, Odette" uniqKey="Mariani O" first="Odette" last="Mariani">Odette Mariani</name><affiliation><nlm:affiliation>Institut Curie, Section Médicale, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Sastre, Xavier" sort="Sastre, Xavier" uniqKey="Sastre X" first="Xavier" last="Sastre">Xavier Sastre</name><affiliation><nlm:affiliation>Institut Curie, Section Médicale, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Daujat Chavanieu, Martine" sort="Daujat Chavanieu, Martine" uniqKey="Daujat Chavanieu M" first="Martine" last="Daujat-Chavanieu">Martine Daujat-Chavanieu</name><affiliation><nlm:affiliation>INSERM U1040, Hôpital St Eloi, Montpellier, France.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Yuesheng" sort="Li, Yuesheng" uniqKey="Li Y" first="Yuesheng" last="Li">Yuesheng Li</name><affiliation><nlm:affiliation>Queensland Institute of Medical Research, Brisbane, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Dessein, Alain" sort="Dessein, Alain" uniqKey="Dessein A" first="Alain" last="Dessein">Alain Dessein</name><affiliation><nlm:affiliation>Institut National de la Santé et de la Recherche Médicale (INSERM), UMR906, GIMP, Labex ParaFrap, Aix-Marseille Université, 13005 Marseille, France. Electronic address: alain.dessein@univ-amu.fr.</nlm:affiliation></affiliation></author></analytic><series><title level="j">International journal for parasitology</title><idno type="eISSN">1879-0135</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">MicroRNAs (miRNAs) are short, non-coding RNAs that repress the translation of target gene transcripts. They have been implicated in various activities such as cell proliferation, survival, differentiation, migration and metabolism. We report here the first known miRNome and transcriptome analysis of human livers displaying advanced fibrosis due to Schistosoma japonicum infection. We present evidence that hsa-miR-150-5p, hsa-miR-10a-5p, hsa-miR-199a-3p, hsa-miR-4521, hsa-miR-222/221, hsa-miR-663b and hsa-miR-143-3p (associated without correction) play an important role in hepatic fibrosis by acting on metabolism, organization of the extracellular matrix proteins, lipid mobilization and limitation of oxidative damage stress.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28739251</PMID><DateCreated><Year>2017</Year><Month>07</Month><Day>25</Day></DateCreated><DateRevised><Year>2017</Year><Month>10</Month><Day>23</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-0135</ISSN><JournalIssue CitedMedium="Internet"><Volume>47</Volume><Issue>13</Issue><PubDate><Year>2017</Year><Month>Nov</Month></PubDate></JournalIssue><Title>International journal for parasitology</Title><ISOAbbreviation>Int. J. Parasitol.</ISOAbbreviation></Journal><ArticleTitle>Evidence for an important role of host microRNAs in regulating hepatic fibrosis in humans infected with Schistosoma japonicum.</ArticleTitle><Pagination><MedlinePgn>823-830</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0020-7519(17)30207-2</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ijpara.2017.05.007</ELocationID><Abstract><AbstractText>MicroRNAs (miRNAs) are short, non-coding RNAs that repress the translation of target gene transcripts. They have been implicated in various activities such as cell proliferation, survival, differentiation, migration and metabolism. We report here the first known miRNome and transcriptome analysis of human livers displaying advanced fibrosis due to Schistosoma japonicum infection. We present evidence that hsa-miR-150-5p, hsa-miR-10a-5p, hsa-miR-199a-3p, hsa-miR-4521, hsa-miR-222/221, hsa-miR-663b and hsa-miR-143-3p (associated without correction) play an important role in hepatic fibrosis by acting on metabolism, organization of the extracellular matrix proteins, lipid mobilization and limitation of oxidative damage stress.</AbstractText><CopyrightInformation>Copyright © 2017 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cabantous</LastName><ForeName>Sandrine</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institut National de la Santé et de la Recherche Médicale (INSERM), UMR906, GIMP, Labex ParaFrap, Aix-Marseille Université, 13005 Marseille, France. Electronic address: sandrine.ambard@univ-amu.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hou</LastName><ForeName>Xunya</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Hunan Institute of Parasitic Diseases, Yueyang, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Louis</LastName><ForeName>Laurence</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>INSERM UMR910, GMGF, Aix Marseille Université, 13005 Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>He</LastName><ForeName>Hongbin</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Hunan Institute of Parasitic Diseases, Yueyang, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mariani</LastName><ForeName>Odette</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Institut Curie, Section Médicale, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sastre</LastName><ForeName>Xavier</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Institut Curie, Section Médicale, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Daujat-Chavanieu</LastName><ForeName>Martine</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>INSERM U1040, Hôpital St Eloi, Montpellier, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Yuesheng</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Queensland Institute of Medical Research, Brisbane, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dessein</LastName><ForeName>Alain</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institut National de la Santé et de la Recherche Médicale (INSERM), UMR906, GIMP, Labex ParaFrap, Aix-Marseille Université, 13005 Marseille, France. Electronic address: alain.dessein@univ-amu.fr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>07</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Int J Parasitol</MedlineTA><NlmUniqueID>0314024</NlmUniqueID><ISSNLinking>0020-7519</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Expression analysis</Keyword><Keyword MajorTopicYN="N">Human schistosomiasis</Keyword><Keyword MajorTopicYN="N">Liver fibrosis</Keyword><Keyword MajorTopicYN="N">MicroRNA</Keyword><Keyword MajorTopicYN="N">Schistosoma japonicum</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>03</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2017</Year><Month>05</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>05</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>7</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>7</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>7</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28739251</ArticleId><ArticleId IdType="pii">S0020-7519(17)30207-2</ArticleId><ArticleId IdType="doi">10.1016/j.ijpara.2017.05.007</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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