The autonomic nervous system as a therapeutic target in heart failure: a scientific position statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology.
Identifieur interne : 000064 ( PubMed/Corpus ); précédent : 000063; suivant : 000065The autonomic nervous system as a therapeutic target in heart failure: a scientific position statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology.
Auteurs : Marc Van Bilsen ; Hitesh C. Patel ; Johann Bauersachs ; Michael Böhm ; Martin Borggrefe ; Dirk Brutsaert ; Andrew J S. Coats ; Rudolf A. De Boer ; Gilles W. De Keulenaer ; Gerasimos S. Filippatos ; John Floras ; Guido Grassi ; Ewa A. Jankowska ; Lilian Kornet ; Ida G. Lunde ; Christoph Maack ; Felix Mahfoud ; Piero Pollesello ; Piotr Ponikowski ; Frank Ruschitzka ; Hani N. Sabbah ; Harold D. Schultz ; Petar Seferovic ; Riemer H J A. Slart ; Peter Taggart ; Carlo G. Tocchetti ; Linda W. Van Laake ; Faiez Zannad ; Stephane Heymans ; Alexander R. LyonSource :
- European journal of heart failure [ 1879-0844 ] ; 2017.
Abstract
Despite improvements in medical therapy and device-based treatment, heart failure (HF) continues to impose enormous burdens on patients and health care systems worldwide. Alterations in autonomic nervous system (ANS) activity contribute to cardiac disease progression, and the recent development of invasive techniques and electrical stimulation devices has opened new avenues for specific targeting of the sympathetic and parasympathetic branches of the ANS. The Heart Failure Association of the European Society of Cardiology recently organized an expert workshop which brought together clinicians, trialists and basic scientists to discuss the ANS as a therapeutic target in HF. The questions addressed were: (i) What are the abnormalities of ANS in HF patients? (ii) What methods are available to measure autonomic dysfunction? (iii) What therapeutic interventions are available to target the ANS in patients with HF, and what are their specific strengths and weaknesses? (iv) What have we learned from previous ANS trials? (v) How should we proceed in the future?
DOI: 10.1002/ejhf.921
PubMed: 28949064
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The autonomic nervous system as a therapeutic target in heart failure: a scientific position statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology.</title><author><name sortKey="Van Bilsen, Marc" sort="Van Bilsen, Marc" uniqKey="Van Bilsen M" first="Marc" last="Van Bilsen">Marc Van Bilsen</name><affiliation><nlm:affiliation>Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Hospital, Maastricht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Patel, Hitesh C" sort="Patel, Hitesh C" uniqKey="Patel H" first="Hitesh C" last="Patel">Hitesh C. Patel</name><affiliation><nlm:affiliation>National Institute for Health Research (NIHR) Cardiovascular Biomedical Research Unit, Royal Brompton Hospital, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Bauersachs, Johann" sort="Bauersachs, Johann" uniqKey="Bauersachs J" first="Johann" last="Bauersachs">Johann Bauersachs</name><affiliation><nlm:affiliation>Department of Cardiology and Angiology, Medical School Hannover, Hannover, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Bohm, Michael" sort="Bohm, Michael" uniqKey="Bohm M" first="Michael" last="Böhm">Michael Böhm</name><affiliation><nlm:affiliation>Clinic for Internal Medicine III, Cardiology, Angiology and Intensive Internal Medicine, Homburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Borggrefe, Martin" sort="Borggrefe, Martin" uniqKey="Borggrefe M" first="Martin" last="Borggrefe">Martin Borggrefe</name><affiliation><nlm:affiliation>First Department of Medicine, Cardiology Division, University Medical Centre Mannheim, Mannheim, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Brutsaert, Dirk" sort="Brutsaert, Dirk" uniqKey="Brutsaert D" first="Dirk" last="Brutsaert">Dirk Brutsaert</name><affiliation><nlm:affiliation>Department of Cardiology, Antwerp University, Antwerp, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Coats, Andrew J S" sort="Coats, Andrew J S" uniqKey="Coats A" first="Andrew J S" last="Coats">Andrew J S. Coats</name><affiliation><nlm:affiliation>Department of Medicine, Monash University, Melbourne, Vic, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="De Boer, Rudolf A" sort="De Boer, Rudolf A" uniqKey="De Boer R" first="Rudolf A" last="De Boer">Rudolf A. De Boer</name><affiliation><nlm:affiliation>Department of Cardiology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="De Keulenaer, Gilles W" sort="De Keulenaer, Gilles W" uniqKey="De Keulenaer G" first="Gilles W" last="De Keulenaer">Gilles W. De Keulenaer</name><affiliation><nlm:affiliation>Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Filippatos, Gerasimos S" sort="Filippatos, Gerasimos S" uniqKey="Filippatos G" first="Gerasimos S" last="Filippatos">Gerasimos S. Filippatos</name><affiliation><nlm:affiliation>Department of Cardiology, School of Medicine, National and Kapodistrian University of Athens, Athens University Hospital Attikon, Athens, Greece.</nlm:affiliation></affiliation></author><author><name sortKey="Floras, John" sort="Floras, John" uniqKey="Floras J" first="John" last="Floras">John Floras</name><affiliation><nlm:affiliation>University Health Network and Sinai Health System Division of Cardiology, Peter Munk Cardiac Centre, Toronto General and Lunenfeld-Tanenbaum Research Institutes, University of Toronto, Toronto, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Grassi, Guido" sort="Grassi, Guido" uniqKey="Grassi G" first="Guido" last="Grassi">Guido Grassi</name><affiliation><nlm:affiliation>Clinica Medica, Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Jankowska, Ewa A" sort="Jankowska, Ewa A" uniqKey="Jankowska E" first="Ewa A" last="Jankowska">Ewa A. Jankowska</name><affiliation><nlm:affiliation>Department of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Kornet, Lilian" sort="Kornet, Lilian" uniqKey="Kornet L" first="Lilian" last="Kornet">Lilian Kornet</name><affiliation><nlm:affiliation>Medtronic, Inc., Bakken Research Centre, Maastricht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Lunde, Ida G" sort="Lunde, Ida G" uniqKey="Lunde I" first="Ida G" last="Lunde">Ida G. Lunde</name><affiliation><nlm:affiliation>Institute for Experimental Medical Research, Oslo University Hospital, University of Oslo, Oslo, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Maack, Christoph" sort="Maack, Christoph" uniqKey="Maack C" first="Christoph" last="Maack">Christoph Maack</name><affiliation><nlm:affiliation>Clinic for Internal Medicine III, Cardiology, Angiology and Intensive Internal Medicine, Homburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Mahfoud, Felix" sort="Mahfoud, Felix" uniqKey="Mahfoud F" first="Felix" last="Mahfoud">Felix Mahfoud</name><affiliation><nlm:affiliation>Clinic for Internal Medicine III, Cardiology, Angiology and Intensive Internal Medicine, Homburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Pollesello, Piero" sort="Pollesello, Piero" uniqKey="Pollesello P" first="Piero" last="Pollesello">Piero Pollesello</name><affiliation><nlm:affiliation>Critical Care, Orion Pharma, Espoo, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Ponikowski, Piotr" sort="Ponikowski, Piotr" uniqKey="Ponikowski P" first="Piotr" last="Ponikowski">Piotr Ponikowski</name><affiliation><nlm:affiliation>Department of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Ruschitzka, Frank" sort="Ruschitzka, Frank" uniqKey="Ruschitzka F" first="Frank" last="Ruschitzka">Frank Ruschitzka</name><affiliation><nlm:affiliation>University Heart Centre, University Hospital Zurich, Zurich, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Sabbah, Hani N" sort="Sabbah, Hani N" uniqKey="Sabbah H" first="Hani N" last="Sabbah">Hani N. Sabbah</name><affiliation><nlm:affiliation>Department of Medicine, Division of Cardiovascular Medicine, Henry Ford Hospital, Detroit, MI, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Schultz, Harold D" sort="Schultz, Harold D" uniqKey="Schultz H" first="Harold D" last="Schultz">Harold D. Schultz</name><affiliation><nlm:affiliation>Department of Cellular and Integrative Physiology, University of Nebraska College of Medicine, Omaha, NE, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Seferovic, Petar" sort="Seferovic, Petar" uniqKey="Seferovic P" first="Petar" last="Seferovic">Petar Seferovic</name><affiliation><nlm:affiliation>Department of Cardiology, Belgrade University Medical Centre, Belgrade, Serbia.</nlm:affiliation></affiliation></author><author><name sortKey="Slart, Riemer H J A" sort="Slart, Riemer H J A" uniqKey="Slart R" first="Riemer H J A" last="Slart">Riemer H J A. Slart</name><affiliation><nlm:affiliation>Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Taggart, Peter" sort="Taggart, Peter" uniqKey="Taggart P" first="Peter" last="Taggart">Peter Taggart</name><affiliation><nlm:affiliation>Department of Cardiovascular Science, University College London, Barts Heart Centre, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Tocchetti, Carlo G" sort="Tocchetti, Carlo G" uniqKey="Tocchetti C" first="Carlo G" last="Tocchetti">Carlo G. Tocchetti</name><affiliation><nlm:affiliation>Department of Translational Medical Sciences, Federico II University, Naples, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Van Laake, Linda W" sort="Van Laake, Linda W" uniqKey="Van Laake L" first="Linda W" last="Van Laake">Linda W. Van Laake</name><affiliation><nlm:affiliation>Department of Cardiology, Heart and Lungs Division, and Regenerative Medicine Centre, University Medical Centre Utrecht, Utrecht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Zannad, Faiez" sort="Zannad, Faiez" uniqKey="Zannad F" first="Faiez" last="Zannad">Faiez Zannad</name><affiliation><nlm:affiliation>INSERM, Centre for Clinical Investigation 9501, Unit 961, University Hospital Centre, Nancy, France.</nlm:affiliation></affiliation></author><author><name sortKey="Heymans, Stephane" sort="Heymans, Stephane" uniqKey="Heymans S" first="Stephane" last="Heymans">Stephane Heymans</name><affiliation><nlm:affiliation>Netherlands Heart Institute, Utrecht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Lyon, Alexander R" sort="Lyon, Alexander R" uniqKey="Lyon A" first="Alexander R" last="Lyon">Alexander R. Lyon</name><affiliation><nlm:affiliation>National Institute for Health Research (NIHR) Cardiovascular Biomedical Research Unit, Royal Brompton Hospital, London, UK.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28949064</idno><idno type="pmid">28949064</idno><idno type="doi">10.1002/ejhf.921</idno><idno type="wicri:Area/PubMed/Corpus">000064</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000064</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The autonomic nervous system as a therapeutic target in heart failure: a scientific position statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology.</title><author><name sortKey="Van Bilsen, Marc" sort="Van Bilsen, Marc" uniqKey="Van Bilsen M" first="Marc" last="Van Bilsen">Marc Van Bilsen</name><affiliation><nlm:affiliation>Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Hospital, Maastricht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Patel, Hitesh C" sort="Patel, Hitesh C" uniqKey="Patel H" first="Hitesh C" last="Patel">Hitesh C. Patel</name><affiliation><nlm:affiliation>National Institute for Health Research (NIHR) Cardiovascular Biomedical Research Unit, Royal Brompton Hospital, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Bauersachs, Johann" sort="Bauersachs, Johann" uniqKey="Bauersachs J" first="Johann" last="Bauersachs">Johann Bauersachs</name><affiliation><nlm:affiliation>Department of Cardiology and Angiology, Medical School Hannover, Hannover, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Bohm, Michael" sort="Bohm, Michael" uniqKey="Bohm M" first="Michael" last="Böhm">Michael Böhm</name><affiliation><nlm:affiliation>Clinic for Internal Medicine III, Cardiology, Angiology and Intensive Internal Medicine, Homburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Borggrefe, Martin" sort="Borggrefe, Martin" uniqKey="Borggrefe M" first="Martin" last="Borggrefe">Martin Borggrefe</name><affiliation><nlm:affiliation>First Department of Medicine, Cardiology Division, University Medical Centre Mannheim, Mannheim, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Brutsaert, Dirk" sort="Brutsaert, Dirk" uniqKey="Brutsaert D" first="Dirk" last="Brutsaert">Dirk Brutsaert</name><affiliation><nlm:affiliation>Department of Cardiology, Antwerp University, Antwerp, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Coats, Andrew J S" sort="Coats, Andrew J S" uniqKey="Coats A" first="Andrew J S" last="Coats">Andrew J S. Coats</name><affiliation><nlm:affiliation>Department of Medicine, Monash University, Melbourne, Vic, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="De Boer, Rudolf A" sort="De Boer, Rudolf A" uniqKey="De Boer R" first="Rudolf A" last="De Boer">Rudolf A. De Boer</name><affiliation><nlm:affiliation>Department of Cardiology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="De Keulenaer, Gilles W" sort="De Keulenaer, Gilles W" uniqKey="De Keulenaer G" first="Gilles W" last="De Keulenaer">Gilles W. De Keulenaer</name><affiliation><nlm:affiliation>Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Filippatos, Gerasimos S" sort="Filippatos, Gerasimos S" uniqKey="Filippatos G" first="Gerasimos S" last="Filippatos">Gerasimos S. Filippatos</name><affiliation><nlm:affiliation>Department of Cardiology, School of Medicine, National and Kapodistrian University of Athens, Athens University Hospital Attikon, Athens, Greece.</nlm:affiliation></affiliation></author><author><name sortKey="Floras, John" sort="Floras, John" uniqKey="Floras J" first="John" last="Floras">John Floras</name><affiliation><nlm:affiliation>University Health Network and Sinai Health System Division of Cardiology, Peter Munk Cardiac Centre, Toronto General and Lunenfeld-Tanenbaum Research Institutes, University of Toronto, Toronto, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Grassi, Guido" sort="Grassi, Guido" uniqKey="Grassi G" first="Guido" last="Grassi">Guido Grassi</name><affiliation><nlm:affiliation>Clinica Medica, Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Jankowska, Ewa A" sort="Jankowska, Ewa A" uniqKey="Jankowska E" first="Ewa A" last="Jankowska">Ewa A. Jankowska</name><affiliation><nlm:affiliation>Department of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Kornet, Lilian" sort="Kornet, Lilian" uniqKey="Kornet L" first="Lilian" last="Kornet">Lilian Kornet</name><affiliation><nlm:affiliation>Medtronic, Inc., Bakken Research Centre, Maastricht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Lunde, Ida G" sort="Lunde, Ida G" uniqKey="Lunde I" first="Ida G" last="Lunde">Ida G. Lunde</name><affiliation><nlm:affiliation>Institute for Experimental Medical Research, Oslo University Hospital, University of Oslo, Oslo, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Maack, Christoph" sort="Maack, Christoph" uniqKey="Maack C" first="Christoph" last="Maack">Christoph Maack</name><affiliation><nlm:affiliation>Clinic for Internal Medicine III, Cardiology, Angiology and Intensive Internal Medicine, Homburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Mahfoud, Felix" sort="Mahfoud, Felix" uniqKey="Mahfoud F" first="Felix" last="Mahfoud">Felix Mahfoud</name><affiliation><nlm:affiliation>Clinic for Internal Medicine III, Cardiology, Angiology and Intensive Internal Medicine, Homburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Pollesello, Piero" sort="Pollesello, Piero" uniqKey="Pollesello P" first="Piero" last="Pollesello">Piero Pollesello</name><affiliation><nlm:affiliation>Critical Care, Orion Pharma, Espoo, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Ponikowski, Piotr" sort="Ponikowski, Piotr" uniqKey="Ponikowski P" first="Piotr" last="Ponikowski">Piotr Ponikowski</name><affiliation><nlm:affiliation>Department of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Ruschitzka, Frank" sort="Ruschitzka, Frank" uniqKey="Ruschitzka F" first="Frank" last="Ruschitzka">Frank Ruschitzka</name><affiliation><nlm:affiliation>University Heart Centre, University Hospital Zurich, Zurich, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Sabbah, Hani N" sort="Sabbah, Hani N" uniqKey="Sabbah H" first="Hani N" last="Sabbah">Hani N. Sabbah</name><affiliation><nlm:affiliation>Department of Medicine, Division of Cardiovascular Medicine, Henry Ford Hospital, Detroit, MI, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Schultz, Harold D" sort="Schultz, Harold D" uniqKey="Schultz H" first="Harold D" last="Schultz">Harold D. Schultz</name><affiliation><nlm:affiliation>Department of Cellular and Integrative Physiology, University of Nebraska College of Medicine, Omaha, NE, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Seferovic, Petar" sort="Seferovic, Petar" uniqKey="Seferovic P" first="Petar" last="Seferovic">Petar Seferovic</name><affiliation><nlm:affiliation>Department of Cardiology, Belgrade University Medical Centre, Belgrade, Serbia.</nlm:affiliation></affiliation></author><author><name sortKey="Slart, Riemer H J A" sort="Slart, Riemer H J A" uniqKey="Slart R" first="Riemer H J A" last="Slart">Riemer H J A. Slart</name><affiliation><nlm:affiliation>Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Taggart, Peter" sort="Taggart, Peter" uniqKey="Taggart P" first="Peter" last="Taggart">Peter Taggart</name><affiliation><nlm:affiliation>Department of Cardiovascular Science, University College London, Barts Heart Centre, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Tocchetti, Carlo G" sort="Tocchetti, Carlo G" uniqKey="Tocchetti C" first="Carlo G" last="Tocchetti">Carlo G. Tocchetti</name><affiliation><nlm:affiliation>Department of Translational Medical Sciences, Federico II University, Naples, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Van Laake, Linda W" sort="Van Laake, Linda W" uniqKey="Van Laake L" first="Linda W" last="Van Laake">Linda W. Van Laake</name><affiliation><nlm:affiliation>Department of Cardiology, Heart and Lungs Division, and Regenerative Medicine Centre, University Medical Centre Utrecht, Utrecht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Zannad, Faiez" sort="Zannad, Faiez" uniqKey="Zannad F" first="Faiez" last="Zannad">Faiez Zannad</name><affiliation><nlm:affiliation>INSERM, Centre for Clinical Investigation 9501, Unit 961, University Hospital Centre, Nancy, France.</nlm:affiliation></affiliation></author><author><name sortKey="Heymans, Stephane" sort="Heymans, Stephane" uniqKey="Heymans S" first="Stephane" last="Heymans">Stephane Heymans</name><affiliation><nlm:affiliation>Netherlands Heart Institute, Utrecht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Lyon, Alexander R" sort="Lyon, Alexander R" uniqKey="Lyon A" first="Alexander R" last="Lyon">Alexander R. Lyon</name><affiliation><nlm:affiliation>National Institute for Health Research (NIHR) Cardiovascular Biomedical Research Unit, Royal Brompton Hospital, London, UK.</nlm:affiliation></affiliation></author></analytic><series><title level="j">European journal of heart failure</title><idno type="eISSN">1879-0844</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Despite improvements in medical therapy and device-based treatment, heart failure (HF) continues to impose enormous burdens on patients and health care systems worldwide. Alterations in autonomic nervous system (ANS) activity contribute to cardiac disease progression, and the recent development of invasive techniques and electrical stimulation devices has opened new avenues for specific targeting of the sympathetic and parasympathetic branches of the ANS. The Heart Failure Association of the European Society of Cardiology recently organized an expert workshop which brought together clinicians, trialists and basic scientists to discuss the ANS as a therapeutic target in HF. The questions addressed were: (i) What are the abnormalities of ANS in HF patients? (ii) What methods are available to measure autonomic dysfunction? (iii) What therapeutic interventions are available to target the ANS in patients with HF, and what are their specific strengths and weaknesses? (iv) What have we learned from previous ANS trials? (v) How should we proceed in the future?</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28949064</PMID><DateCreated><Year>2017</Year><Month>09</Month><Day>26</Day></DateCreated><DateRevised><Year>2017</Year><Month>11</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-0844</ISSN><JournalIssue CitedMedium="Internet"><Volume>19</Volume><Issue>11</Issue><PubDate><Year>2017</Year><Month>Nov</Month></PubDate></JournalIssue><Title>European journal of heart failure</Title><ISOAbbreviation>Eur. J. Heart Fail.</ISOAbbreviation></Journal><ArticleTitle>The autonomic nervous system as a therapeutic target in heart failure: a scientific position statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology.</ArticleTitle><Pagination><MedlinePgn>1361-1378</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/ejhf.921</ELocationID><Abstract><AbstractText>Despite improvements in medical therapy and device-based treatment, heart failure (HF) continues to impose enormous burdens on patients and health care systems worldwide. Alterations in autonomic nervous system (ANS) activity contribute to cardiac disease progression, and the recent development of invasive techniques and electrical stimulation devices has opened new avenues for specific targeting of the sympathetic and parasympathetic branches of the ANS. The Heart Failure Association of the European Society of Cardiology recently organized an expert workshop which brought together clinicians, trialists and basic scientists to discuss the ANS as a therapeutic target in HF. The questions addressed were: (i) What are the abnormalities of ANS in HF patients? (ii) What methods are available to measure autonomic dysfunction? (iii) What therapeutic interventions are available to target the ANS in patients with HF, and what are their specific strengths and weaknesses? (iv) What have we learned from previous ANS trials? (v) How should we proceed in the future?</AbstractText><CopyrightInformation>© 2017 The Authors. European Journal of Heart Failure © 2017 European Society of Cardiology.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>van Bilsen</LastName><ForeName>Marc</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Hospital, Maastricht, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Patel</LastName><ForeName>Hitesh C</ForeName><Initials>HC</Initials><AffiliationInfo><Affiliation>National Institute for Health Research (NIHR) Cardiovascular Biomedical Research Unit, Royal Brompton Hospital, London, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>National Heart and Lung Institute, Imperial College London, London, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Baker Heart and Diabetes Institute, Melbourne, Vic, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bauersachs</LastName><ForeName>Johann</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Cardiology and Angiology, Medical School Hannover, Hannover, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Böhm</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Clinic for Internal Medicine III, Cardiology, Angiology and Intensive Internal Medicine, Homburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Borggrefe</LastName><ForeName>Martin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>First Department of Medicine, Cardiology Division, University Medical Centre Mannheim, Mannheim, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>German Centre for Cardiovascular Research, Mannheim, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brutsaert</LastName><ForeName>Dirk</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Cardiology, Antwerp University, Antwerp, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Coats</LastName><ForeName>Andrew J S</ForeName><Initials>AJS</Initials><AffiliationInfo><Affiliation>Department of Medicine, Monash University, Melbourne, Vic, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medicine, University of Warwick, Coventry, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Boer</LastName><ForeName>Rudolf A</ForeName><Initials>RA</Initials><AffiliationInfo><Affiliation>Department of Cardiology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Keulenaer</LastName><ForeName>Gilles W</ForeName><Initials>GW</Initials><AffiliationInfo><Affiliation>Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Filippatos</LastName><ForeName>Gerasimos S</ForeName><Initials>GS</Initials><AffiliationInfo><Affiliation>Department of Cardiology, School of Medicine, National and Kapodistrian University of Athens, Athens University Hospital Attikon, Athens, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Floras</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>University Health Network and Sinai Health System Division of Cardiology, Peter Munk Cardiac Centre, Toronto General and Lunenfeld-Tanenbaum Research Institutes, University of Toronto, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grassi</LastName><ForeName>Guido</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Clinica Medica, Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>IRCCS Multimedica, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jankowska</LastName><ForeName>Ewa A</ForeName><Initials>EA</Initials><AffiliationInfo><Affiliation>Department of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Heart Diseases, Military Hospital, Wroclaw, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kornet</LastName><ForeName>Lilian</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Medtronic, Inc., Bakken Research Centre, Maastricht, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lunde</LastName><ForeName>Ida G</ForeName><Initials>IG</Initials><AffiliationInfo><Affiliation>Institute for Experimental Medical Research, Oslo University Hospital, University of Oslo, Oslo, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maack</LastName><ForeName>Christoph</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Clinic for Internal Medicine III, Cardiology, Angiology and Intensive Internal Medicine, Homburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mahfoud</LastName><ForeName>Felix</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Clinic for Internal Medicine III, Cardiology, Angiology and Intensive Internal Medicine, Homburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pollesello</LastName><ForeName>Piero</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Critical Care, Orion Pharma, Espoo, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ponikowski</LastName><ForeName>Piotr</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Heart Diseases, Military Hospital, Wroclaw, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ruschitzka</LastName><ForeName>Frank</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>University Heart Centre, University Hospital Zurich, Zurich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sabbah</LastName><ForeName>Hani N</ForeName><Initials>HN</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Cardiovascular Medicine, Henry Ford Hospital, Detroit, MI, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schultz</LastName><ForeName>Harold D</ForeName><Initials>HD</Initials><AffiliationInfo><Affiliation>Department of Cellular and Integrative Physiology, University of Nebraska College of Medicine, Omaha, NE, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seferovic</LastName><ForeName>Petar</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Cardiology, Belgrade University Medical Centre, Belgrade, Serbia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Slart</LastName><ForeName>Riemer H J A</ForeName><Initials>RHJA</Initials><AffiliationInfo><Affiliation>Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biomedical Photonic Imaging, Faculty of Science and Technology, University of Twente, Enschede, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Taggart</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Cardiovascular Science, University College London, Barts Heart Centre, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tocchetti</LastName><ForeName>Carlo G</ForeName><Initials>CG</Initials><AffiliationInfo><Affiliation>Department of Translational Medical Sciences, Federico II University, Naples, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Van Laake</LastName><ForeName>Linda W</ForeName><Initials>LW</Initials><AffiliationInfo><Affiliation>Department of Cardiology, Heart and Lungs Division, and Regenerative Medicine Centre, University Medical Centre Utrecht, Utrecht, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zannad</LastName><ForeName>Faiez</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>INSERM, Centre for Clinical Investigation 9501, Unit 961, University Hospital Centre, Nancy, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Cardiology, Nancy University, University of the Lorraine, Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Heymans</LastName><ForeName>Stephane</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Netherlands Heart Institute, Utrecht, the Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Cardiovascular Sciences, Leuven University, Leuven, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lyon</LastName><ForeName>Alexander R</ForeName><Initials>AR</Initials><AffiliationInfo><Affiliation>National Institute for Health Research (NIHR) Cardiovascular Biomedical Research Unit, Royal Brompton Hospital, London, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>National Heart and Lung Institute, Imperial College London, London, UK.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>09</Month><Day>26</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Eur J Heart Fail</MedlineTA><NlmUniqueID>100887595</NlmUniqueID><ISSNLinking>1388-9842</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Autonomic dysfunction</Keyword><Keyword MajorTopicYN="N">Devices and nerve ablation</Keyword><Keyword MajorTopicYN="N">Heart failure</Keyword><Keyword MajorTopicYN="N">Parasympathetic</Keyword><Keyword MajorTopicYN="N">Sympathetic</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>02</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2017</Year><Month>04</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>05</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>9</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>9</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>9</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28949064</ArticleId><ArticleId IdType="doi">10.1002/ejhf.921</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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