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Reproductive profiles and risk of breast cancer subtypes: a multi-center case-only study.

Identifieur interne : 000028 ( PubMed/Corpus ); précédent : 000027; suivant : 000029

Reproductive profiles and risk of breast cancer subtypes: a multi-center case-only study.

Auteurs : Olivier Brouckaert ; Anja Rudolph ; Annouschka Laenen ; Renske Keeman ; Manjeet K. Bolla ; Qin Wang ; Adelheid Soubry ; Hans Wildiers ; Irene L. Andrulis ; Volker Arndt ; Matthias W. Beckmann ; Javier Benitez ; Carl Blomqvist ; Stig E. Bojesen ; Hiltrud Brauch ; Paul Brennan ; Hermann Brenner ; Georgia Chenevix-Trench ; Ji-Yeob Choi ; Sten Cornelissen ; Fergus J. Couch ; Angela Cox ; Simon S. Cross ; Kamila Czene ; Mikael Eriksson ; Peter A. Fasching ; Jonine Figueroa ; Henrik Flyger ; Graham G. Giles ; Anna González-Neira ; Pascal Guénel ; Per Hall ; Antoinette Hollestelle ; John L. Hopper ; Hidemi Ito ; Michael Jones ; Daehee Kang ; Julia A. Knight ; Veli-Matti Kosma ; Jingmei Li ; Annika Lindblom ; Jenna Lilyquist ; Artitaya Lophatananon ; Arto Mannermaa ; Siranoush Manoukian ; Sara Margolin ; Keitaro Matsuo ; Kenneth Muir ; Heli Nevanlinna ; Paolo Peterlongo ; Katri Pylk S ; Suleeporn Saajrang ; Caroline Seynaeve ; Chen-Yang Shen ; Xiao-Ou Shu ; Melissa C. Southey ; Anthony Swerdlow ; Soo-Hwang Teo ; Rob A E M. Tollenaar ; Thérèse Truong ; Chiu-Chen Tseng ; Alexandra J. Van Den Broek ; Carolien H M. Van Deurzen ; Robert Winqvist ; Anna H. Wu ; Cheng Har Yip ; Jyh-Cherng Yu ; Wei Zheng ; Roger L. Milne ; Paul D P. Pharoah ; Douglas F. Easton ; Marjanka K. Schmidt ; Montserrat Garcia-Closas ; Jenny Chang-Claude ; Diether Lambrechts ; Patrick Neven

Source :

RBID : pubmed:29116004

Abstract

Previous studies have shown that reproductive factors are differentially associated with breast cancer (BC) risk by subtypes. The aim of this study was to investigate associations between reproductive factors and BC subtypes, and whether these vary by age at diagnosis.

DOI: 10.1186/s13058-017-0909-3
PubMed: 29116004

Links to Exploration step

pubmed:29116004

Le document en format XML

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<nlm:affiliation>Department of Obstetrics and Gynaecology, Jan Yperman Hospital, Ypres, Belgium.</nlm:affiliation>
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<name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K" last="Bolla">Manjeet K. Bolla</name>
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<name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name>
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<name sortKey="Soubry, Adelheid" sort="Soubry, Adelheid" uniqKey="Soubry A" first="Adelheid" last="Soubry">Adelheid Soubry</name>
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<name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L" last="Andrulis">Irene L. Andrulis</name>
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<nlm:affiliation>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada.</nlm:affiliation>
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<name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name>
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<name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W" last="Beckmann">Matthias W. Beckmann</name>
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<nlm:affiliation>Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.</nlm:affiliation>
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<name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name>
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<name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name>
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<nlm:affiliation>Department of Oncology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.</nlm:affiliation>
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<author>
<name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E" last="Bojesen">Stig E. Bojesen</name>
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<nlm:affiliation>Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.</nlm:affiliation>
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<name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name>
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<nlm:affiliation>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.</nlm:affiliation>
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<name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name>
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<nlm:affiliation>International Agency for Research on Cancer, Lyon, France.</nlm:affiliation>
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<name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name>
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<nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation>
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<author>
<name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name>
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<nlm:affiliation>Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.</nlm:affiliation>
</affiliation>
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<author>
<name sortKey="Choi, Ji Yeob" sort="Choi, Ji Yeob" uniqKey="Choi J" first="Ji-Yeob" last="Choi">Ji-Yeob Choi</name>
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<nlm:affiliation>Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Cornelissen, Sten" sort="Cornelissen, Sten" uniqKey="Cornelissen S" first="Sten" last="Cornelissen">Sten Cornelissen</name>
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<nlm:affiliation>Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands.</nlm:affiliation>
</affiliation>
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<author>
<name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J" last="Couch">Fergus J. Couch</name>
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<nlm:affiliation>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name>
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<nlm:affiliation>Sheffield Cancer Research, Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.</nlm:affiliation>
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<author>
<name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S" last="Cross">Simon S. Cross</name>
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<nlm:affiliation>Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK.</nlm:affiliation>
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<name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name>
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<nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation>
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<name sortKey="Eriksson, Mikael" sort="Eriksson, Mikael" uniqKey="Eriksson M" first="Mikael" last="Eriksson">Mikael Eriksson</name>
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<nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation>
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<name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A" last="Fasching">Peter A. Fasching</name>
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<nlm:affiliation>Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name>
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<nlm:affiliation>Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh Medical School, Edinburgh, UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name>
<affiliation>
<nlm:affiliation>Department of Breast Surgery, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name>
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<nlm:affiliation>Cancer Epidemiology & Intelligence Division, Cancer Council Victoria, Melbourne, Australia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name>
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<nlm:affiliation>Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name>
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<nlm:affiliation>Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif, France.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name>
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<nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation>
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<author>
<name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name>
<affiliation>
<nlm:affiliation>Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name>
<affiliation>
<nlm:affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne, Australia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Ito, Hidemi" sort="Ito, Hidemi" uniqKey="Ito H" first="Hidemi" last="Ito">Hidemi Ito</name>
<affiliation>
<nlm:affiliation>Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Jones, Michael" sort="Jones, Michael" uniqKey="Jones M" first="Michael" last="Jones">Michael Jones</name>
<affiliation>
<nlm:affiliation>Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Kang, Daehee" sort="Kang, Daehee" uniqKey="Kang D" first="Daehee" last="Kang">Daehee Kang</name>
<affiliation>
<nlm:affiliation>Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A" last="Knight">Julia A. Knight</name>
<affiliation>
<nlm:affiliation>Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name>
<affiliation>
<nlm:affiliation>Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name>
<affiliation>
<nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name>
<affiliation>
<nlm:affiliation>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Lilyquist, Jenna" sort="Lilyquist, Jenna" uniqKey="Lilyquist J" first="Jenna" last="Lilyquist">Jenna Lilyquist</name>
<affiliation>
<nlm:affiliation>Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Lophatananon, Artitaya" sort="Lophatananon, Artitaya" uniqKey="Lophatananon A" first="Artitaya" last="Lophatananon">Artitaya Lophatananon</name>
<affiliation>
<nlm:affiliation>Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name>
<affiliation>
<nlm:affiliation>Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name>
<affiliation>
<nlm:affiliation>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Milan, Italy.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name>
<affiliation>
<nlm:affiliation>Department of Oncology - Pathology, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Matsuo, Keitaro" sort="Matsuo, Keitaro" uniqKey="Matsuo K" first="Keitaro" last="Matsuo">Keitaro Matsuo</name>
<affiliation>
<nlm:affiliation>Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name>
<affiliation>
<nlm:affiliation>Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name>
<affiliation>
<nlm:affiliation>Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name>
<affiliation>
<nlm:affiliation>IFOM, The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name>
<affiliation>
<nlm:affiliation>Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, Finland.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Saajrang, Suleeporn" sort="Saajrang, Suleeporn" uniqKey="Saajrang S" first="Suleeporn" last="Saajrang">Suleeporn Saajrang</name>
<affiliation>
<nlm:affiliation>National Cancer Institute, Bangkok, Thailand.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name>
<affiliation>
<nlm:affiliation>Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Shen, Chen Yang" sort="Shen, Chen Yang" uniqKey="Shen C" first="Chen-Yang" last="Shen">Chen-Yang Shen</name>
<affiliation>
<nlm:affiliation>School of Public Health, China Medical University, Taichung, Taiwan.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name>
<affiliation>
<nlm:affiliation>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C" last="Southey">Melissa C. Southey</name>
<affiliation>
<nlm:affiliation>Department of Pathology, The University of Melbourne, Melbourne, Australia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name>
<affiliation>
<nlm:affiliation>Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Teo, Soo Hwang" sort="Teo, Soo Hwang" uniqKey="Teo S" first="Soo-Hwang" last="Teo">Soo-Hwang Teo</name>
<affiliation>
<nlm:affiliation>Cancer Research Initiatives Foundation, Subang Jaya, Selangor, Malaysia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Tollenaar, Rob A E M" sort="Tollenaar, Rob A E M" uniqKey="Tollenaar R" first="Rob A E M" last="Tollenaar">Rob A E M. Tollenaar</name>
<affiliation>
<nlm:affiliation>Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name>
<affiliation>
<nlm:affiliation>Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif, France.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Tseng, Chiu Chen" sort="Tseng, Chiu Chen" uniqKey="Tseng C" first="Chiu-Chen" last="Tseng">Chiu-Chen Tseng</name>
<affiliation>
<nlm:affiliation>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Van Den Broek, Alexandra J" sort="Van Den Broek, Alexandra J" uniqKey="Van Den Broek A" first="Alexandra J" last="Van Den Broek">Alexandra J. Van Den Broek</name>
<affiliation>
<nlm:affiliation>Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Van Deurzen, Carolien H M" sort="Van Deurzen, Carolien H M" uniqKey="Van Deurzen C" first="Carolien H M" last="Van Deurzen">Carolien H M. Van Deurzen</name>
<affiliation>
<nlm:affiliation>Department of Pathology, Erasmus University Medical Center, Rotterdam, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name>
<affiliation>
<nlm:affiliation>Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, Finland.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Wu, Anna H" sort="Wu, Anna H" uniqKey="Wu A" first="Anna H" last="Wu">Anna H. Wu</name>
<affiliation>
<nlm:affiliation>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Yip, Cheng Har" sort="Yip, Cheng Har" uniqKey="Yip C" first="Cheng Har" last="Yip">Cheng Har Yip</name>
<affiliation>
<nlm:affiliation>Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Yu, Jyh Cherng" sort="Yu, Jyh Cherng" uniqKey="Yu J" first="Jyh-Cherng" last="Yu">Jyh-Cherng Yu</name>
<affiliation>
<nlm:affiliation>Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name>
<affiliation>
<nlm:affiliation>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.</nlm:affiliation>
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<author>
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<nlm:affiliation>Cancer Epidemiology & Intelligence Division, Cancer Council Victoria, Melbourne, Australia.</nlm:affiliation>
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<nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care University of Cambridge, Cambridge, UK.</nlm:affiliation>
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<name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F" last="Easton">Douglas F. Easton</name>
<affiliation>
<nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care University of Cambridge, Cambridge, UK.</nlm:affiliation>
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<name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K" last="Schmidt">Marjanka K. Schmidt</name>
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<nlm:affiliation>Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands.</nlm:affiliation>
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<author>
<name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name>
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<nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.</nlm:affiliation>
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</author>
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<name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name>
<affiliation>
<nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation>
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<name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name>
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<nlm:affiliation>Center for Cancer Biology, VIB, Leuven, Belgium. Diether.Lambrechts@vib-kuleuven.be.</nlm:affiliation>
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<author>
<name sortKey="Neven, Patrick" sort="Neven, Patrick" uniqKey="Neven P" first="Patrick" last="Neven">Patrick Neven</name>
<affiliation>
<nlm:affiliation>Department of Oncology, Leuven Multidisciplinary Breast Cancer, University Hospital Leuven, KU Leuven, Leuven, Belgium.</nlm:affiliation>
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</titleStmt>
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<idno type="RBID">pubmed:29116004</idno>
<idno type="pmid">29116004</idno>
<idno type="doi">10.1186/s13058-017-0909-3</idno>
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<nlm:affiliation>Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.</nlm:affiliation>
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<nlm:affiliation>Department of Oncology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.</nlm:affiliation>
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<name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E" last="Bojesen">Stig E. Bojesen</name>
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<nlm:affiliation>Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.</nlm:affiliation>
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<nlm:affiliation>International Agency for Research on Cancer, Lyon, France.</nlm:affiliation>
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<nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation>
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<name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name>
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<nlm:affiliation>Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.</nlm:affiliation>
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<name sortKey="Choi, Ji Yeob" sort="Choi, Ji Yeob" uniqKey="Choi J" first="Ji-Yeob" last="Choi">Ji-Yeob Choi</name>
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<nlm:affiliation>Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation>
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<name sortKey="Cornelissen, Sten" sort="Cornelissen, Sten" uniqKey="Cornelissen S" first="Sten" last="Cornelissen">Sten Cornelissen</name>
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<nlm:affiliation>Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands.</nlm:affiliation>
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<nlm:affiliation>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation>
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<name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name>
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<nlm:affiliation>Sheffield Cancer Research, Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.</nlm:affiliation>
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<nlm:affiliation>Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK.</nlm:affiliation>
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<name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name>
<affiliation>
<nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation>
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<name sortKey="Eriksson, Mikael" sort="Eriksson, Mikael" uniqKey="Eriksson M" first="Mikael" last="Eriksson">Mikael Eriksson</name>
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<nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation>
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<name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A" last="Fasching">Peter A. Fasching</name>
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<nlm:affiliation>Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.</nlm:affiliation>
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<nlm:affiliation>Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh Medical School, Edinburgh, UK.</nlm:affiliation>
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<name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name>
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<nlm:affiliation>Department of Breast Surgery, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.</nlm:affiliation>
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<name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name>
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<nlm:affiliation>Cancer Epidemiology & Intelligence Division, Cancer Council Victoria, Melbourne, Australia.</nlm:affiliation>
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<name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name>
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<nlm:affiliation>Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain.</nlm:affiliation>
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<nlm:affiliation>Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif, France.</nlm:affiliation>
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<nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation>
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<name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name>
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<nlm:affiliation>Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.</nlm:affiliation>
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<nlm:affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne, Australia.</nlm:affiliation>
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<name sortKey="Ito, Hidemi" sort="Ito, Hidemi" uniqKey="Ito H" first="Hidemi" last="Ito">Hidemi Ito</name>
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<name sortKey="Jones, Michael" sort="Jones, Michael" uniqKey="Jones M" first="Michael" last="Jones">Michael Jones</name>
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<nlm:affiliation>Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.</nlm:affiliation>
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<name sortKey="Kang, Daehee" sort="Kang, Daehee" uniqKey="Kang D" first="Daehee" last="Kang">Daehee Kang</name>
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<nlm:affiliation>Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation>
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<nlm:affiliation>Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland.</nlm:affiliation>
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<name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name>
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<nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation>
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<name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name>
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<nlm:affiliation>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation>
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</author>
<author>
<name sortKey="Lilyquist, Jenna" sort="Lilyquist, Jenna" uniqKey="Lilyquist J" first="Jenna" last="Lilyquist">Jenna Lilyquist</name>
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<nlm:affiliation>Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation>
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<name sortKey="Lophatananon, Artitaya" sort="Lophatananon, Artitaya" uniqKey="Lophatananon A" first="Artitaya" last="Lophatananon">Artitaya Lophatananon</name>
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<nlm:affiliation>Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK.</nlm:affiliation>
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</author>
<author>
<name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name>
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<nlm:affiliation>Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland.</nlm:affiliation>
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<name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name>
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<nlm:affiliation>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Milan, Italy.</nlm:affiliation>
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<author>
<name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name>
<affiliation>
<nlm:affiliation>Department of Oncology - Pathology, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Matsuo, Keitaro" sort="Matsuo, Keitaro" uniqKey="Matsuo K" first="Keitaro" last="Matsuo">Keitaro Matsuo</name>
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<nlm:affiliation>Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.</nlm:affiliation>
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</author>
<author>
<name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name>
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<nlm:affiliation>Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name>
<affiliation>
<nlm:affiliation>Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name>
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<nlm:affiliation>IFOM, The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy.</nlm:affiliation>
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<name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name>
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<nlm:affiliation>Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, Finland.</nlm:affiliation>
</affiliation>
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<name sortKey="Saajrang, Suleeporn" sort="Saajrang, Suleeporn" uniqKey="Saajrang S" first="Suleeporn" last="Saajrang">Suleeporn Saajrang</name>
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<nlm:affiliation>National Cancer Institute, Bangkok, Thailand.</nlm:affiliation>
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<name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name>
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<nlm:affiliation>Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
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<name sortKey="Shen, Chen Yang" sort="Shen, Chen Yang" uniqKey="Shen C" first="Chen-Yang" last="Shen">Chen-Yang Shen</name>
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<nlm:affiliation>School of Public Health, China Medical University, Taichung, Taiwan.</nlm:affiliation>
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<name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name>
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<nlm:affiliation>Department of Pathology, The University of Melbourne, Melbourne, Australia.</nlm:affiliation>
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<name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name>
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<nlm:affiliation>Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.</nlm:affiliation>
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<name sortKey="Teo, Soo Hwang" sort="Teo, Soo Hwang" uniqKey="Teo S" first="Soo-Hwang" last="Teo">Soo-Hwang Teo</name>
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<name sortKey="Tollenaar, Rob A E M" sort="Tollenaar, Rob A E M" uniqKey="Tollenaar R" first="Rob A E M" last="Tollenaar">Rob A E M. Tollenaar</name>
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<nlm:affiliation>Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation>
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<name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name>
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<nlm:affiliation>Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif, France.</nlm:affiliation>
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<name sortKey="Tseng, Chiu Chen" sort="Tseng, Chiu Chen" uniqKey="Tseng C" first="Chiu-Chen" last="Tseng">Chiu-Chen Tseng</name>
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<nlm:affiliation>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.</nlm:affiliation>
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<name sortKey="Van Den Broek, Alexandra J" sort="Van Den Broek, Alexandra J" uniqKey="Van Den Broek A" first="Alexandra J" last="Van Den Broek">Alexandra J. Van Den Broek</name>
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<nlm:affiliation>Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Van Deurzen, Carolien H M" sort="Van Deurzen, Carolien H M" uniqKey="Van Deurzen C" first="Carolien H M" last="Van Deurzen">Carolien H M. Van Deurzen</name>
<affiliation>
<nlm:affiliation>Department of Pathology, Erasmus University Medical Center, Rotterdam, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name>
<affiliation>
<nlm:affiliation>Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, Finland.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Wu, Anna H" sort="Wu, Anna H" uniqKey="Wu A" first="Anna H" last="Wu">Anna H. Wu</name>
<affiliation>
<nlm:affiliation>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Yip, Cheng Har" sort="Yip, Cheng Har" uniqKey="Yip C" first="Cheng Har" last="Yip">Cheng Har Yip</name>
<affiliation>
<nlm:affiliation>Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Yu, Jyh Cherng" sort="Yu, Jyh Cherng" uniqKey="Yu J" first="Jyh-Cherng" last="Yu">Jyh-Cherng Yu</name>
<affiliation>
<nlm:affiliation>Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name>
<affiliation>
<nlm:affiliation>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L" last="Milne">Roger L. Milne</name>
<affiliation>
<nlm:affiliation>Cancer Epidemiology & Intelligence Division, Cancer Council Victoria, Melbourne, Australia.</nlm:affiliation>
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</author>
<author>
<name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D P" last="Pharoah">Paul D P. Pharoah</name>
<affiliation>
<nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care University of Cambridge, Cambridge, UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F" last="Easton">Douglas F. Easton</name>
<affiliation>
<nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care University of Cambridge, Cambridge, UK.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K" last="Schmidt">Marjanka K. Schmidt</name>
<affiliation>
<nlm:affiliation>Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name>
<affiliation>
<nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name>
<affiliation>
<nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name>
<affiliation>
<nlm:affiliation>Center for Cancer Biology, VIB, Leuven, Belgium. Diether.Lambrechts@vib-kuleuven.be.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Neven, Patrick" sort="Neven, Patrick" uniqKey="Neven P" first="Patrick" last="Neven">Patrick Neven</name>
<affiliation>
<nlm:affiliation>Department of Oncology, Leuven Multidisciplinary Breast Cancer, University Hospital Leuven, KU Leuven, Leuven, Belgium.</nlm:affiliation>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Breast cancer research : BCR</title>
<idno type="eISSN">1465-542X</idno>
<imprint>
<date when="2017" type="published">2017</date>
</imprint>
</series>
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<front>
<div type="abstract" xml:lang="en">Previous studies have shown that reproductive factors are differentially associated with breast cancer (BC) risk by subtypes. The aim of this study was to investigate associations between reproductive factors and BC subtypes, and whether these vary by age at diagnosis.</div>
</front>
</TEI>
<pubmed>
<MedlineCitation Status="In-Process" Owner="NLM">
<PMID Version="1">29116004</PMID>
<DateCreated>
<Year>2017</Year>
<Month>11</Month>
<Day>08</Day>
</DateCreated>
<DateRevised>
<Year>2017</Year>
<Month>11</Month>
<Day>08</Day>
</DateRevised>
<Article PubModel="Electronic">
<Journal>
<ISSN IssnType="Electronic">1465-542X</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>19</Volume>
<Issue>1</Issue>
<PubDate>
<Year>2017</Year>
<Month>Nov</Month>
<Day>07</Day>
</PubDate>
</JournalIssue>
<Title>Breast cancer research : BCR</Title>
<ISOAbbreviation>Breast Cancer Res.</ISOAbbreviation>
</Journal>
<ArticleTitle>Reproductive profiles and risk of breast cancer subtypes: a multi-center case-only study.</ArticleTitle>
<Pagination>
<MedlinePgn>119</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1186/s13058-017-0909-3</ELocationID>
<Abstract>
<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Previous studies have shown that reproductive factors are differentially associated with breast cancer (BC) risk by subtypes. The aim of this study was to investigate associations between reproductive factors and BC subtypes, and whether these vary by age at diagnosis.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We used pooled data on tumor markers (estrogen and progesterone receptor, human epidermal growth factor receptor-2 (HER2)) and reproductive risk factors (parity, age at first full-time pregnancy (FFTP) and age at menarche) from 28,095 patients with invasive BC from 34 studies participating in the Breast Cancer Association Consortium (BCAC). In a case-only analysis, we used logistic regression to assess associations between reproductive factors and BC subtype compared to luminal A tumors as a reference. The interaction between age and parity in BC subtype risk was also tested, across all ages and, because age was modeled non-linearly, specifically at ages 35, 55 and 75 years.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Parous women were more likely to be diagnosed with triple negative BC (TNBC) than with luminal A BC, irrespective of age (OR for parity = 1.38, 95% CI 1.16-1.65, p = 0.0004; p for interaction with age = 0.076). Parous women were also more likely to be diagnosed with luminal and non-luminal HER2-like BCs and this effect was slightly more pronounced at an early age (p for interaction with age = 0.037 and 0.030, respectively). For instance, women diagnosed at age 35 were 1.48 (CI 1.01-2.16) more likely to have luminal HER2-like BC than luminal A BC, while this association was not significant at age 75 (OR = 0.72, CI 0.45-1.14). While age at menarche was not significantly associated with BC subtype, increasing age at FFTP was non-linearly associated with TNBC relative to luminal A BC. An age at FFTP of 25 versus 20 years lowered the risk for TNBC (OR = 0.78, CI 0.70-0.88, p < 0.0001), but this effect was not apparent at a later FFTP.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our main findings suggest that parity is associated with TNBC across all ages at BC diagnosis, whereas the association with luminal HER2-like BC was present only for early onset BC.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y">
<Author ValidYN="Y">
<LastName>Brouckaert</LastName>
<ForeName>Olivier</ForeName>
<Initials>O</Initials>
<AffiliationInfo>
<Affiliation>Department of Obstetrics and Gynaecology, Jan Yperman Hospital, Ypres, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Rudolph</LastName>
<ForeName>Anja</ForeName>
<Initials>A</Initials>
<AffiliationInfo>
<Affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Laenen</LastName>
<ForeName>Annouschka</ForeName>
<Initials>A</Initials>
<AffiliationInfo>
<Affiliation>Centre for Biostatistics and Statistical Bioinformatics, KU Leuven, Leuven, Belgium.</Affiliation>
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</Author>
<Author ValidYN="Y">
<LastName>Keeman</LastName>
<ForeName>Renske</ForeName>
<Initials>R</Initials>
<AffiliationInfo>
<Affiliation>Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands.</Affiliation>
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</Author>
<Author ValidYN="Y">
<LastName>Bolla</LastName>
<ForeName>Manjeet K</ForeName>
<Initials>MK</Initials>
<AffiliationInfo>
<Affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care University of Cambridge, Cambridge, UK.</Affiliation>
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</Author>
<Author ValidYN="Y">
<LastName>Wang</LastName>
<ForeName>Qin</ForeName>
<Initials>Q</Initials>
<AffiliationInfo>
<Affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care University of Cambridge, Cambridge, UK.</Affiliation>
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<LastName>Soubry</LastName>
<ForeName>Adelheid</ForeName>
<Initials>A</Initials>
<AffiliationInfo>
<Affiliation>Epidemiology Research Unit, Department of Public Health and Primary Care, Faculty of Medicine, KU Leuven - University of Leuven, Leuven, Belgium.</Affiliation>
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</Author>
<Author ValidYN="Y">
<LastName>Wildiers</LastName>
<ForeName>Hans</ForeName>
<Initials>H</Initials>
<AffiliationInfo>
<Affiliation>Department of Oncology, Leuven Multidisciplinary Breast Cancer, University Hospital Leuven, KU Leuven, Leuven, Belgium.</Affiliation>
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<Author ValidYN="Y">
<LastName>Andrulis</LastName>
<ForeName>Irene L</ForeName>
<Initials>IL</Initials>
<AffiliationInfo>
<Affiliation>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Molecular Genetics, University of Toronto, Toronto, Canada.</Affiliation>
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<Author ValidYN="Y">
<LastName>Arndt</LastName>
<ForeName>Volker</ForeName>
<Initials>V</Initials>
<AffiliationInfo>
<Affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation>
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<Author ValidYN="Y">
<LastName>Beckmann</LastName>
<ForeName>Matthias W</ForeName>
<Initials>MW</Initials>
<AffiliationInfo>
<Affiliation>Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.</Affiliation>
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<LastName>Benitez</LastName>
<ForeName>Javier</ForeName>
<Initials>J</Initials>
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<Affiliation>Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain.</Affiliation>
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<Affiliation>Centro de Investigación en Red de Enfermedades Raras, Valencia, Spain.</Affiliation>
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<Author ValidYN="Y">
<LastName>Blomqvist</LastName>
<ForeName>Carl</ForeName>
<Initials>C</Initials>
<AffiliationInfo>
<Affiliation>Department of Oncology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.</Affiliation>
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<Author ValidYN="Y">
<LastName>Bojesen</LastName>
<ForeName>Stig E</ForeName>
<Initials>SE</Initials>
<AffiliationInfo>
<Affiliation>Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</Affiliation>
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<Author ValidYN="Y">
<LastName>Brauch</LastName>
<ForeName>Hiltrud</ForeName>
<Initials>H</Initials>
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<Affiliation>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.</Affiliation>
</AffiliationInfo>
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<Affiliation>University of Tübingen, Tübingen, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation>
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<LastName>Brennan</LastName>
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<LastName>Brenner</LastName>
<ForeName>Hermann</ForeName>
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<Affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation>
</AffiliationInfo>
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<Affiliation>German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation>
</AffiliationInfo>
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<Affiliation>Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.</Affiliation>
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<LastName>Chenevix-Trench</LastName>
<ForeName>Georgia</ForeName>
<Initials>G</Initials>
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<Affiliation>Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.</Affiliation>
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<LastName>Choi</LastName>
<ForeName>Ji-Yeob</ForeName>
<Initials>JY</Initials>
<AffiliationInfo>
<Affiliation>Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.</Affiliation>
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<Affiliation>Cancer Research Institute, Seoul National University, Seoul, Korea.</Affiliation>
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<LastName>Cornelissen</LastName>
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<Affiliation>Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands.</Affiliation>
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<Affiliation>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.</Affiliation>
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<LastName>Cox</LastName>
<ForeName>Angela</ForeName>
<Initials>A</Initials>
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<Affiliation>Sheffield Cancer Research, Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.</Affiliation>
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<LastName>Cross</LastName>
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<Affiliation>Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK.</Affiliation>
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<LastName>Czene</LastName>
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<LastName>Eriksson</LastName>
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<Affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</Affiliation>
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<Affiliation>Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.</Affiliation>
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<Affiliation>David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA, USA.</Affiliation>
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<Affiliation>Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh Medical School, Edinburgh, UK.</Affiliation>
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<LastName>Flyger</LastName>
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<Affiliation>Department of Breast Surgery, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.</Affiliation>
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<LastName>Giles</LastName>
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<Initials>GG</Initials>
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<Affiliation>Cancer Epidemiology & Intelligence Division, Cancer Council Victoria, Melbourne, Australia.</Affiliation>
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<Affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne, Australia.</Affiliation>
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<LastName>González-Neira</LastName>
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<Affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</Affiliation>
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<LastName>Hollestelle</LastName>
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<Affiliation>Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.</Affiliation>
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<LastName>Hopper</LastName>
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<Initials>JL</Initials>
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<Affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne, Australia.</Affiliation>
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<Affiliation>Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.</Affiliation>
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<Initials>D</Initials>
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<Affiliation>Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.</Affiliation>
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<AffiliationInfo>
<Affiliation>Cancer Research Institute, Seoul National University, Seoul, Korea.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.</Affiliation>
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<LastName>Knight</LastName>
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<Affiliation>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.</Affiliation>
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<LastName>Kosma</LastName>
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<Initials>VM</Initials>
<AffiliationInfo>
<Affiliation>Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland.</Affiliation>
</AffiliationInfo>
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<Affiliation>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland.</Affiliation>
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<LastName>Lindblom</LastName>
<ForeName>Annika</ForeName>
<Initials>A</Initials>
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<Affiliation>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.</Affiliation>
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<ForeName>Artitaya</ForeName>
<Initials>A</Initials>
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<Affiliation>Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK.</Affiliation>
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<Affiliation>Institute of Population Health, University of Manchester, Manchester, UK.</Affiliation>
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<Initials>A</Initials>
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<Affiliation>Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland.</Affiliation>
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<Affiliation>Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland.</Affiliation>
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<Affiliation>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland.</Affiliation>
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<Initials>S</Initials>
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<Affiliation>Department of Oncology - Pathology, Karolinska Institutet, Stockholm, Sweden.</Affiliation>
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</AffiliationInfo>
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