Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study.
Identifieur interne : 000021 ( PubMed/Corpus ); précédent : 000020; suivant : 000022Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study.
Auteurs : Azmeraw T. Amare ; Klaus Oliver Schubert ; Liping Hou ; Scott R. Clark ; Sergi Papiol ; Urs Heilbronner ; Franziska Degenhardt ; Fasil Tekola-Ayele ; Yi-Hsiang Hsu ; Tatyana Shekhtman ; Mazda Adli ; Nirmala Akula ; Kazufumi Akiyama ; Raffaella Ardau ; Bárbara Arias ; Jean-Michel Aubry ; Lena Backlund ; Abesh Kumar Bhattacharjee ; Frank Bellivier ; Antonio Benabarre ; Susanne Bengesser ; Joanna M. Biernacka ; Armin Birner ; Clara Brichant-Petitjean ; Pablo Cervantes ; Hsi-Chung Chen ; Caterina Chillotti ; Sven Cichon ; Cristiana Cruceanu ; Piotr M. Czerski ; Nina Dalkner ; Alexandre Dayer ; Maria Del Zompo ; J Raymond Depaulo ; Bruno Étain ; Peter Falkai ; Andreas J. Forstner ; Louise Frisen ; Mark A. Frye ; Janice M. Fullerton ; Sébastien Gard ; Julie S. Garnham ; Fernando S. Goes ; Maria Grigoroiu-Serbanescu ; Paul Grof ; Ryota Hashimoto ; Joanna Hauser ; Stefan Herms ; Per Hoffmann ; Andrea Hofmann ; Stephane Jamain ; Esther Jiménez ; Jean-Pierre Kahn ; Layla Kassem ; Po-Hsiu Kuo ; Tadafumi Kato ; John Kelsoe ; Sarah Kittel-Schneider ; Sebastian Kliwicki ; Barbara König ; Ichiro Kusumi ; Gonzalo Laje ; Mikael Landén ; Catharina Lavebratt ; Marion Leboyer ; Susan G. Leckband ; Alfonso Tortorella ; Mirko Manchia ; Lina Martinsson ; Michael J. Mccarthy ; Susan Mcelroy ; Francesc Colom ; Marina Mitjans ; Francis M. Mondimore ; Palmiero Monteleone ; Caroline M. Nievergelt ; Markus M. Nöthen ; Tomas Novák ; Claire O'Donovan ; Norio Ozaki ; Urban Ösby ; Andrea Pfennig ; James B. Potash ; Andreas Reif ; Eva Reininghaus ; Guy A. Rouleau ; Janusz K. Rybakowski ; Martin Schalling ; Peter R. Schofield ; Barbara W. Schweizer ; Giovanni Severino ; Paul D. Shilling ; Katzutaka Shimoda ; Christian Simhandl ; Claire M. Slaney ; Alessio Squassina ; Thomas Stamm ; Pavla Stopkova ; Mario Maj ; Gustavo Turecki ; Eduard Vieta ; Julia Volkert ; Stephanie Witt ; Adam Wright ; Peter P. Zandi ; Philip B. Mitchell ; Michael Bauer ; Martin Alda ; Marcella Rietschel ; Francis J. Mcmahon ; Thomas G. Schulze ; Bernhard T. BauneSource :
- JAMA psychiatry [ 2168-6238 ] ; 2017.
Abstract
Lithium is a first-line mood stabilizer for the treatment of bipolar affective disorder (BPAD). However, the efficacy of lithium varies widely, with a nonresponse rate of up to 30%. Biological response markers are lacking. Genetic factors are thought to mediate treatment response to lithium, and there is a previously reported genetic overlap between BPAD and schizophrenia (SCZ).
DOI: 10.1001/jamapsychiatry.2017.3433
PubMed: 29121268
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study.</title><author><name sortKey="Amare, Azmeraw T" sort="Amare, Azmeraw T" uniqKey="Amare A" first="Azmeraw T" last="Amare">Azmeraw T. Amare</name><affiliation><nlm:affiliation>Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, South Australia, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Schubert, Klaus Oliver" sort="Schubert, Klaus Oliver" uniqKey="Schubert K" first="Klaus Oliver" last="Schubert">Klaus Oliver Schubert</name><affiliation><nlm:affiliation>Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, South Australia, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Hou, Liping" sort="Hou, Liping" uniqKey="Hou L" first="Liping" last="Hou">Liping Hou</name><affiliation><nlm:affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Clark, Scott R" sort="Clark, Scott R" uniqKey="Clark S" first="Scott R" last="Clark">Scott R. Clark</name><affiliation><nlm:affiliation>Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, South Australia, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Papiol, Sergi" sort="Papiol, Sergi" uniqKey="Papiol S" first="Sergi" last="Papiol">Sergi Papiol</name><affiliation><nlm:affiliation>Institute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig-Maximilian University of Munich, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Heilbronner, Urs" sort="Heilbronner, Urs" uniqKey="Heilbronner U" first="Urs" last="Heilbronner">Urs Heilbronner</name><affiliation><nlm:affiliation>Institute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig-Maximilian University of Munich, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Degenhardt, Franziska" sort="Degenhardt, Franziska" uniqKey="Degenhardt F" first="Franziska" last="Degenhardt">Franziska Degenhardt</name><affiliation><nlm:affiliation>Institute of Human Genetics and Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Tekola Ayele, Fasil" sort="Tekola Ayele, Fasil" uniqKey="Tekola Ayele F" first="Fasil" last="Tekola-Ayele">Fasil Tekola-Ayele</name><affiliation><nlm:affiliation>Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Hsu, Yi Hsiang" sort="Hsu, Yi Hsiang" uniqKey="Hsu Y" first="Yi-Hsiang" last="Hsu">Yi-Hsiang Hsu</name><affiliation><nlm:affiliation>Hebrew SeniorLife Institute for Aging Research, Harvard Medical School, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Shekhtman, Tatyana" sort="Shekhtman, Tatyana" uniqKey="Shekhtman T" first="Tatyana" last="Shekhtman">Tatyana Shekhtman</name><affiliation><nlm:affiliation>Department of Psychiatry, University of California San Diego.</nlm:affiliation></affiliation></author><author><name sortKey="Adli, Mazda" sort="Adli, Mazda" uniqKey="Adli M" first="Mazda" last="Adli">Mazda Adli</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Akula, Nirmala" sort="Akula, Nirmala" uniqKey="Akula N" first="Nirmala" last="Akula">Nirmala Akula</name><affiliation><nlm:affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Akiyama, Kazufumi" sort="Akiyama, Kazufumi" uniqKey="Akiyama K" first="Kazufumi" last="Akiyama">Kazufumi Akiyama</name><affiliation><nlm:affiliation>Department of Biological Psychiatry and Neuroscience, Dokkyo Medical University School of Medicine, Mibu, Tochigi, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Ardau, Raffaella" sort="Ardau, Raffaella" uniqKey="Ardau R" first="Raffaella" last="Ardau">Raffaella Ardau</name><affiliation><nlm:affiliation>Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Arias, Barbara" sort="Arias, Barbara" uniqKey="Arias B" first="Bárbara" last="Arias">Bárbara Arias</name><affiliation><nlm:affiliation>Unitat de Zoologia i Antropologia Biològica (Dpt Biologia Evolutiva, Ecologia i Ciències Ambientals), Facultat de Biologia and Institut de Biomedicina, University of Barcelona, Centro de Investigación Biomédica en Red de Salud Mental, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Aubry, Jean Michel" sort="Aubry, Jean Michel" uniqKey="Aubry J" first="Jean-Michel" last="Aubry">Jean-Michel Aubry</name><affiliation><nlm:affiliation>Department of Psychiatry, Mood Disorders Unit, Geneva University Hospitals, Geneva, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Backlund, Lena" sort="Backlund, Lena" uniqKey="Backlund L" first="Lena" last="Backlund">Lena Backlund</name><affiliation><nlm:affiliation>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden, and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Bhattacharjee, Abesh Kumar" sort="Bhattacharjee, Abesh Kumar" uniqKey="Bhattacharjee A" first="Abesh Kumar" last="Bhattacharjee">Abesh Kumar Bhattacharjee</name><affiliation><nlm:affiliation>Department of Psychiatry, University of California San Diego.</nlm:affiliation></affiliation></author><author><name sortKey="Bellivier, Frank" sort="Bellivier, Frank" uniqKey="Bellivier F" first="Frank" last="Bellivier">Frank Bellivier</name><affiliation><nlm:affiliation>Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche Scientifique 1144, Université Paris Diderot, Département de Psychiatrie et de Médecine Addictologique, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Saint-Louis-Lariboisière-F. Widal, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Benabarre, Antonio" sort="Benabarre, Antonio" uniqKey="Benabarre A" first="Antonio" last="Benabarre">Antonio Benabarre</name><affiliation><nlm:affiliation>Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red Salud Mental, Barcelona, Catalonia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Bengesser, Susanne" sort="Bengesser, Susanne" uniqKey="Bengesser S" first="Susanne" last="Bengesser">Susanne Bengesser</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Biernacka, Joanna M" sort="Biernacka, Joanna M" uniqKey="Biernacka J" first="Joanna M" last="Biernacka">Joanna M. Biernacka</name><affiliation><nlm:affiliation>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.</nlm:affiliation></affiliation></author><author><name sortKey="Birner, Armin" sort="Birner, Armin" uniqKey="Birner A" first="Armin" last="Birner">Armin Birner</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Brichant Petitjean, Clara" sort="Brichant Petitjean, Clara" uniqKey="Brichant Petitjean C" first="Clara" last="Brichant-Petitjean">Clara Brichant-Petitjean</name><affiliation><nlm:affiliation>Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche Scientifique 1144, Université Paris Diderot, Département de Psychiatrie et de Médecine Addictologique, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Saint-Louis-Lariboisière-F. Widal, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Cervantes, Pablo" sort="Cervantes, Pablo" uniqKey="Cervantes P" first="Pablo" last="Cervantes">Pablo Cervantes</name><affiliation><nlm:affiliation>The Neuromodulation Unit, McGill University Health Centre, Montreal, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Hsi Chung" sort="Chen, Hsi Chung" uniqKey="Chen H" first="Hsi-Chung" last="Chen">Hsi-Chung Chen</name><affiliation><nlm:affiliation>Department of Psychiatry and Center of Sleep Disorders, National Taiwan University Hospital, Taipei, Taiwan.</nlm:affiliation></affiliation></author><author><name sortKey="Chillotti, Caterina" sort="Chillotti, Caterina" uniqKey="Chillotti C" first="Caterina" last="Chillotti">Caterina Chillotti</name><affiliation><nlm:affiliation>Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Cichon, Sven" sort="Cichon, Sven" uniqKey="Cichon S" first="Sven" last="Cichon">Sven Cichon</name><affiliation><nlm:affiliation>Institute of Human Genetics and Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Cruceanu, Cristiana" sort="Cruceanu, Cristiana" uniqKey="Cruceanu C" first="Cristiana" last="Cruceanu">Cristiana Cruceanu</name><affiliation><nlm:affiliation>Douglas Mental Health University Institute, McGill University, Montreal, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Czerski, Piotr M" sort="Czerski, Piotr M" uniqKey="Czerski P" first="Piotr M" last="Czerski">Piotr M. Czerski</name><affiliation><nlm:affiliation>Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Dalkner, Nina" sort="Dalkner, Nina" uniqKey="Dalkner N" first="Nina" last="Dalkner">Nina Dalkner</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Dayer, Alexandre" sort="Dayer, Alexandre" uniqKey="Dayer A" first="Alexandre" last="Dayer">Alexandre Dayer</name><affiliation><nlm:affiliation>Department of Psychiatry, Mood Disorders Unit, Geneva University Hospitals, Geneva, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Del Zompo, Maria" sort="Del Zompo, Maria" uniqKey="Del Zompo M" first="Maria" last="Del Zompo">Maria Del Zompo</name><affiliation><nlm:affiliation>Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Depaulo, J Raymond" sort="Depaulo, J Raymond" uniqKey="Depaulo J" first="J Raymond" last="Depaulo">J Raymond Depaulo</name><affiliation><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Etain, Bruno" sort="Etain, Bruno" uniqKey="Etain B" first="Bruno" last="Étain">Bruno Étain</name><affiliation><nlm:affiliation>Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche Scientifique 1144, Université Paris Diderot, Département de Psychiatrie et de Médecine Addictologique, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Saint-Louis-Lariboisière-F. Widal, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Falkai, Peter" sort="Falkai, Peter" uniqKey="Falkai P" first="Peter" last="Falkai">Peter Falkai</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychotherapy, Ludwig-Maximilian University of Munich, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Forstner, Andreas J" sort="Forstner, Andreas J" uniqKey="Forstner A" first="Andreas J" last="Forstner">Andreas J. Forstner</name><affiliation><nlm:affiliation>Institute of Human Genetics and Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Frisen, Louise" sort="Frisen, Louise" uniqKey="Frisen L" first="Louise" last="Frisen">Louise Frisen</name><affiliation><nlm:affiliation>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden, and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Frye, Mark A" sort="Frye, Mark A" uniqKey="Frye M" first="Mark A" last="Frye">Mark A. Frye</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota.</nlm:affiliation></affiliation></author><author><name sortKey="Fullerton, Janice M" sort="Fullerton, Janice M" uniqKey="Fullerton J" first="Janice M" last="Fullerton">Janice M. Fullerton</name><affiliation><nlm:affiliation>Neuroscience Research Australia, Sydney, New South Wales, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Gard, Sebastien" sort="Gard, Sebastien" uniqKey="Gard S" first="Sébastien" last="Gard">Sébastien Gard</name><affiliation><nlm:affiliation>Service de Psychiatrie, Hôpital Charles Perrens, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Garnham, Julie S" sort="Garnham, Julie S" uniqKey="Garnham J" first="Julie S" last="Garnham">Julie S. Garnham</name><affiliation><nlm:affiliation>Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Goes, Fernando S" sort="Goes, Fernando S" uniqKey="Goes F" first="Fernando S" last="Goes">Fernando S. Goes</name><affiliation><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Grigoroiu Serbanescu, Maria" sort="Grigoroiu Serbanescu, Maria" uniqKey="Grigoroiu Serbanescu M" first="Maria" last="Grigoroiu-Serbanescu">Maria Grigoroiu-Serbanescu</name><affiliation><nlm:affiliation>Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania.</nlm:affiliation></affiliation></author><author><name sortKey="Grof, Paul" sort="Grof, Paul" uniqKey="Grof P" first="Paul" last="Grof">Paul Grof</name><affiliation><nlm:affiliation>Mood Disorders Center of Ottawa, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Hashimoto, Ryota" sort="Hashimoto, Ryota" uniqKey="Hashimoto R" first="Ryota" last="Hashimoto">Ryota Hashimoto</name><affiliation><nlm:affiliation>Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Osaka, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Hauser, Joanna" sort="Hauser, Joanna" uniqKey="Hauser J" first="Joanna" last="Hauser">Joanna Hauser</name><affiliation><nlm:affiliation>Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Herms, Stefan" sort="Herms, Stefan" uniqKey="Herms S" first="Stefan" last="Herms">Stefan Herms</name><affiliation><nlm:affiliation>Institute of Human Genetics and Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hoffmann, Per" sort="Hoffmann, Per" uniqKey="Hoffmann P" first="Per" last="Hoffmann">Per Hoffmann</name><affiliation><nlm:affiliation>Institute of Human Genetics and Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hofmann, Andrea" sort="Hofmann, Andrea" uniqKey="Hofmann A" first="Andrea" last="Hofmann">Andrea Hofmann</name><affiliation><nlm:affiliation>Institute of Human Genetics and Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Jamain, Stephane" sort="Jamain, Stephane" uniqKey="Jamain S" first="Stephane" last="Jamain">Stephane Jamain</name><affiliation><nlm:affiliation>Institut National de la Santé et de la Recherche Médicale Unité 955, Psychiatrie Translationnelle, Créteil, France.</nlm:affiliation></affiliation></author><author><name sortKey="Jimenez, Esther" sort="Jimenez, Esther" uniqKey="Jimenez E" first="Esther" last="Jiménez">Esther Jiménez</name><affiliation><nlm:affiliation>Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red Salud Mental, Barcelona, Catalonia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Kahn, Jean Pierre" sort="Kahn, Jean Pierre" uniqKey="Kahn J" first="Jean-Pierre" last="Kahn">Jean-Pierre Kahn</name><affiliation><nlm:affiliation>Service de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de Nancy, Université de Lorraine, Nancy, France.</nlm:affiliation></affiliation></author><author><name sortKey="Kassem, Layla" sort="Kassem, Layla" uniqKey="Kassem L" first="Layla" last="Kassem">Layla Kassem</name><affiliation><nlm:affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Kuo, Po Hsiu" sort="Kuo, Po Hsiu" uniqKey="Kuo P" first="Po-Hsiu" last="Kuo">Po-Hsiu Kuo</name><affiliation><nlm:affiliation>Department of Public Health and Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.</nlm:affiliation></affiliation></author><author><name sortKey="Kato, Tadafumi" sort="Kato, Tadafumi" uniqKey="Kato T" first="Tadafumi" last="Kato">Tadafumi Kato</name><affiliation><nlm:affiliation>Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Kelsoe, John" sort="Kelsoe, John" uniqKey="Kelsoe J" first="John" last="Kelsoe">John Kelsoe</name><affiliation><nlm:affiliation>Department of Psychiatry, University of California San Diego.</nlm:affiliation></affiliation></author><author><name sortKey="Kittel Schneider, Sarah" sort="Kittel Schneider, Sarah" uniqKey="Kittel Schneider S" first="Sarah" last="Kittel-Schneider">Sarah Kittel-Schneider</name><affiliation><nlm:affiliation>Department of Psychiatry, Psychosomatic Medicine, and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Kliwicki, Sebastian" sort="Kliwicki, Sebastian" uniqKey="Kliwicki S" first="Sebastian" last="Kliwicki">Sebastian Kliwicki</name><affiliation><nlm:affiliation>Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Konig, Barbara" sort="Konig, Barbara" uniqKey="Konig B" first="Barbara" last="König">Barbara König</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychotherapeutic Medicine, Landesklinikum Neunkirchen, Neunkirchen, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Kusumi, Ichiro" sort="Kusumi, Ichiro" uniqKey="Kusumi I" first="Ichiro" last="Kusumi">Ichiro Kusumi</name><affiliation><nlm:affiliation>Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Laje, Gonzalo" sort="Laje, Gonzalo" uniqKey="Laje G" first="Gonzalo" last="Laje">Gonzalo Laje</name><affiliation><nlm:affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Landen, Mikael" sort="Landen, Mikael" uniqKey="Landen M" first="Mikael" last="Landén">Mikael Landén</name><affiliation><nlm:affiliation>Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the Gothenburg University, Gothenburg, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Lavebratt, Catharina" sort="Lavebratt, Catharina" uniqKey="Lavebratt C" first="Catharina" last="Lavebratt">Catharina Lavebratt</name><affiliation><nlm:affiliation>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden, and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Leboyer, Marion" sort="Leboyer, Marion" uniqKey="Leboyer M" first="Marion" last="Leboyer">Marion Leboyer</name><affiliation><nlm:affiliation>Inserm U955, Translational Psychiatry Laboratory, Université Paris-Est-Créteil, Department of Psychiatry and Addictology of Mondor University Hospital, Assistance Publique-Hôpitaux de Paris, Hôpital Albert Chenevier-Henri Mondor, Pôle de Psychiatrie, Créteil, France.</nlm:affiliation></affiliation></author><author><name sortKey="Leckband, Susan G" sort="Leckband, Susan G" uniqKey="Leckband S" first="Susan G" last="Leckband">Susan G. Leckband</name><affiliation><nlm:affiliation>Department of Pharmacy, Veterans Affairs San Diego Healthcare System, San Diego, California.</nlm:affiliation></affiliation></author><author><name sortKey="Tortorella, Alfonso" sort="Tortorella, Alfonso" uniqKey="Tortorella A" first="Alfonso" last="Tortorella">Alfonso Tortorella</name><affiliation><nlm:affiliation>Department of Psychiatry, University of Perugia, Perugia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Manchia, Mirko" sort="Manchia, Mirko" uniqKey="Manchia M" first="Mirko" last="Manchia">Mirko Manchia</name><affiliation><nlm:affiliation>Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Martinsson, Lina" sort="Martinsson, Lina" uniqKey="Martinsson L" first="Lina" last="Martinsson">Lina Martinsson</name><affiliation><nlm:affiliation>Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Mccarthy, Michael J" sort="Mccarthy, Michael J" uniqKey="Mccarthy M" first="Michael J" last="Mccarthy">Michael J. Mccarthy</name><affiliation><nlm:affiliation>Department of Psychiatry, University of California San Diego.</nlm:affiliation></affiliation></author><author><name sortKey="Mcelroy, Susan" sort="Mcelroy, Susan" uniqKey="Mcelroy S" first="Susan" last="Mcelroy">Susan Mcelroy</name><affiliation><nlm:affiliation>Department of Psychiatry, Lindner Center of Hope and University of Cincinnati, Mason, Ohio.</nlm:affiliation></affiliation></author><author><name sortKey="Colom, Francesc" sort="Colom, Francesc" uniqKey="Colom F" first="Francesc" last="Colom">Francesc Colom</name><affiliation><nlm:affiliation>Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red Salud Mental, Barcelona, Catalonia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Mitjans, Marina" sort="Mitjans, Marina" uniqKey="Mitjans M" first="Marina" last="Mitjans">Marina Mitjans</name><affiliation><nlm:affiliation>Centro de Investigación Biomédica en Red de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Mondimore, Francis M" sort="Mondimore, Francis M" uniqKey="Mondimore F" first="Francis M" last="Mondimore">Francis M. Mondimore</name><affiliation><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Monteleone, Palmiero" sort="Monteleone, Palmiero" uniqKey="Monteleone P" first="Palmiero" last="Monteleone">Palmiero Monteleone</name><affiliation><nlm:affiliation>Neurosciences Section, Department of Medicine and Surgery, University of Salerno, Salerno, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Nievergelt, Caroline M" sort="Nievergelt, Caroline M" uniqKey="Nievergelt C" first="Caroline M" last="Nievergelt">Caroline M. Nievergelt</name><affiliation><nlm:affiliation>Department of Psychiatry, University of California San Diego.</nlm:affiliation></affiliation></author><author><name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M" last="Nöthen">Markus M. Nöthen</name><affiliation><nlm:affiliation>Institute of Human Genetics and Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Novak, Tomas" sort="Novak, Tomas" uniqKey="Novak T" first="Tomas" last="Novák">Tomas Novák</name><affiliation><nlm:affiliation>National Institute of Mental Health, Klecany, Czech Republic.</nlm:affiliation></affiliation></author><author><name sortKey="O Donovan, Claire" sort="O Donovan, Claire" uniqKey="O Donovan C" first="Claire" last="O'Donovan">Claire O'Donovan</name><affiliation><nlm:affiliation>Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Ozaki, Norio" sort="Ozaki, Norio" uniqKey="Ozaki N" first="Norio" last="Ozaki">Norio Ozaki</name><affiliation><nlm:affiliation>Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Osby, Urban" sort="Osby, Urban" uniqKey="Osby U" first="Urban" last="Ösby">Urban Ösby</name><affiliation><nlm:affiliation>Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Pfennig, Andrea" sort="Pfennig, Andrea" uniqKey="Pfennig A" first="Andrea" last="Pfennig">Andrea Pfennig</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Potash, James B" sort="Potash, James B" uniqKey="Potash J" first="James B" last="Potash">James B. Potash</name><affiliation><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Reif, Andreas" sort="Reif, Andreas" uniqKey="Reif A" first="Andreas" last="Reif">Andreas Reif</name><affiliation><nlm:affiliation>Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Reininghaus, Eva" sort="Reininghaus, Eva" uniqKey="Reininghaus E" first="Eva" last="Reininghaus">Eva Reininghaus</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Rouleau, Guy A" sort="Rouleau, Guy A" uniqKey="Rouleau G" first="Guy A" last="Rouleau">Guy A. Rouleau</name><affiliation><nlm:affiliation>Montreal Neurological Institute and Hospital, McGill University, Montreal, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Rybakowski, Janusz K" sort="Rybakowski, Janusz K" uniqKey="Rybakowski J" first="Janusz K" last="Rybakowski">Janusz K. Rybakowski</name><affiliation><nlm:affiliation>Department of Psychiatry, Psychosomatic Medicine, and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Schalling, Martin" sort="Schalling, Martin" uniqKey="Schalling M" first="Martin" last="Schalling">Martin Schalling</name><affiliation><nlm:affiliation>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden, and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Schofield, Peter R" sort="Schofield, Peter R" uniqKey="Schofield P" first="Peter R" last="Schofield">Peter R. Schofield</name><affiliation><nlm:affiliation>Neuroscience Research Australia, Sydney, New South Wales, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Schweizer, Barbara W" sort="Schweizer, Barbara W" uniqKey="Schweizer B" first="Barbara W" last="Schweizer">Barbara W. Schweizer</name><affiliation><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Severino, Giovanni" sort="Severino, Giovanni" uniqKey="Severino G" first="Giovanni" last="Severino">Giovanni Severino</name><affiliation><nlm:affiliation>Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Shilling, Paul D" sort="Shilling, Paul D" uniqKey="Shilling P" first="Paul D" last="Shilling">Paul D. Shilling</name><affiliation><nlm:affiliation>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden, and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Shimoda, Katzutaka" sort="Shimoda, Katzutaka" uniqKey="Shimoda K" first="Katzutaka" last="Shimoda">Katzutaka Shimoda</name><affiliation><nlm:affiliation>Department of Psychiatry, Dokkyo University School of Medicine, Mibu, Tochigi, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Simhandl, Christian" sort="Simhandl, Christian" uniqKey="Simhandl C" first="Christian" last="Simhandl">Christian Simhandl</name><affiliation><nlm:affiliation>Bipolar Center Wiener Neustadt, Sigmund Freud University, Medical Faculty, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Slaney, Claire M" sort="Slaney, Claire M" uniqKey="Slaney C" first="Claire M" last="Slaney">Claire M. Slaney</name><affiliation><nlm:affiliation>Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Squassina, Alessio" sort="Squassina, Alessio" uniqKey="Squassina A" first="Alessio" last="Squassina">Alessio Squassina</name><affiliation><nlm:affiliation>Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Stamm, Thomas" sort="Stamm, Thomas" uniqKey="Stamm T" first="Thomas" last="Stamm">Thomas Stamm</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Stopkova, Pavla" sort="Stopkova, Pavla" uniqKey="Stopkova P" first="Pavla" last="Stopkova">Pavla Stopkova</name><affiliation><nlm:affiliation>National Institute of Mental Health, Klecany, Czech Republic.</nlm:affiliation></affiliation></author><author><name sortKey="Maj, Mario" sort="Maj, Mario" uniqKey="Maj M" first="Mario" last="Maj">Mario Maj</name><affiliation><nlm:affiliation>Department of Psychiatry, Second University of Naples, Naples, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Turecki, Gustavo" sort="Turecki, Gustavo" uniqKey="Turecki G" first="Gustavo" last="Turecki">Gustavo Turecki</name><affiliation><nlm:affiliation>Douglas Mental Health University Institute, McGill University, Montreal, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Vieta, Eduard" sort="Vieta, Eduard" uniqKey="Vieta E" first="Eduard" last="Vieta">Eduard Vieta</name><affiliation><nlm:affiliation>Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red Salud Mental, Barcelona, Catalonia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Volkert, Julia" sort="Volkert, Julia" uniqKey="Volkert J" first="Julia" last="Volkert">Julia Volkert</name><affiliation><nlm:affiliation>Department of Psychiatry, Psychosomatic Medicine, and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Witt, Stephanie" sort="Witt, Stephanie" uniqKey="Witt S" first="Stephanie" last="Witt">Stephanie Witt</name><affiliation><nlm:affiliation>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Wright, Adam" sort="Wright, Adam" uniqKey="Wright A" first="Adam" last="Wright">Adam Wright</name><affiliation><nlm:affiliation>School of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, New South Wales, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Zandi, Peter P" sort="Zandi, Peter P" uniqKey="Zandi P" first="Peter P" last="Zandi">Peter P. Zandi</name><affiliation><nlm:affiliation>Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Mitchell, Philip B" sort="Mitchell, Philip B" uniqKey="Mitchell P" first="Philip B" last="Mitchell">Philip B. Mitchell</name><affiliation><nlm:affiliation>School of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, New South Wales, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Bauer, Michael" sort="Bauer, Michael" uniqKey="Bauer M" first="Michael" last="Bauer">Michael Bauer</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Alda, Martin" sort="Alda, Martin" uniqKey="Alda M" first="Martin" last="Alda">Martin Alda</name><affiliation><nlm:affiliation>Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Rietschel, Marcella" sort="Rietschel, Marcella" uniqKey="Rietschel M" first="Marcella" last="Rietschel">Marcella Rietschel</name><affiliation><nlm:affiliation>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Mcmahon, Francis J" sort="Mcmahon, Francis J" uniqKey="Mcmahon F" first="Francis J" last="Mcmahon">Francis J. Mcmahon</name><affiliation><nlm:affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Schulze, Thomas G" sort="Schulze, Thomas G" uniqKey="Schulze T" first="Thomas G" last="Schulze">Thomas G. Schulze</name><affiliation><nlm:affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Baune, Bernhard T" sort="Baune, Bernhard T" uniqKey="Baune B" first="Bernhard T" last="Baune">Bernhard T. Baune</name><affiliation><nlm:affiliation>Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, South Australia, Australia.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:29121268</idno><idno type="pmid">29121268</idno><idno type="doi">10.1001/jamapsychiatry.2017.3433</idno><idno type="wicri:Area/PubMed/Corpus">000021</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000021</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study.</title><author><name sortKey="Amare, Azmeraw T" sort="Amare, Azmeraw T" uniqKey="Amare A" first="Azmeraw T" last="Amare">Azmeraw T. Amare</name><affiliation><nlm:affiliation>Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, South Australia, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Schubert, Klaus Oliver" sort="Schubert, Klaus Oliver" uniqKey="Schubert K" first="Klaus Oliver" last="Schubert">Klaus Oliver Schubert</name><affiliation><nlm:affiliation>Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, South Australia, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Hou, Liping" sort="Hou, Liping" uniqKey="Hou L" first="Liping" last="Hou">Liping Hou</name><affiliation><nlm:affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Clark, Scott R" sort="Clark, Scott R" uniqKey="Clark S" first="Scott R" last="Clark">Scott R. Clark</name><affiliation><nlm:affiliation>Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, South Australia, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Papiol, Sergi" sort="Papiol, Sergi" uniqKey="Papiol S" first="Sergi" last="Papiol">Sergi Papiol</name><affiliation><nlm:affiliation>Institute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig-Maximilian University of Munich, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Heilbronner, Urs" sort="Heilbronner, Urs" uniqKey="Heilbronner U" first="Urs" last="Heilbronner">Urs Heilbronner</name><affiliation><nlm:affiliation>Institute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig-Maximilian University of Munich, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Degenhardt, Franziska" sort="Degenhardt, Franziska" uniqKey="Degenhardt F" first="Franziska" last="Degenhardt">Franziska Degenhardt</name><affiliation><nlm:affiliation>Institute of Human Genetics and Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Tekola Ayele, Fasil" sort="Tekola Ayele, Fasil" uniqKey="Tekola Ayele F" first="Fasil" last="Tekola-Ayele">Fasil Tekola-Ayele</name><affiliation><nlm:affiliation>Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Hsu, Yi Hsiang" sort="Hsu, Yi Hsiang" uniqKey="Hsu Y" first="Yi-Hsiang" last="Hsu">Yi-Hsiang Hsu</name><affiliation><nlm:affiliation>Hebrew SeniorLife Institute for Aging Research, Harvard Medical School, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Shekhtman, Tatyana" sort="Shekhtman, Tatyana" uniqKey="Shekhtman T" first="Tatyana" last="Shekhtman">Tatyana Shekhtman</name><affiliation><nlm:affiliation>Department of Psychiatry, University of California San Diego.</nlm:affiliation></affiliation></author><author><name sortKey="Adli, Mazda" sort="Adli, Mazda" uniqKey="Adli M" first="Mazda" last="Adli">Mazda Adli</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Akula, Nirmala" sort="Akula, Nirmala" uniqKey="Akula N" first="Nirmala" last="Akula">Nirmala Akula</name><affiliation><nlm:affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Akiyama, Kazufumi" sort="Akiyama, Kazufumi" uniqKey="Akiyama K" first="Kazufumi" last="Akiyama">Kazufumi Akiyama</name><affiliation><nlm:affiliation>Department of Biological Psychiatry and Neuroscience, Dokkyo Medical University School of Medicine, Mibu, Tochigi, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Ardau, Raffaella" sort="Ardau, Raffaella" uniqKey="Ardau R" first="Raffaella" last="Ardau">Raffaella Ardau</name><affiliation><nlm:affiliation>Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Arias, Barbara" sort="Arias, Barbara" uniqKey="Arias B" first="Bárbara" last="Arias">Bárbara Arias</name><affiliation><nlm:affiliation>Unitat de Zoologia i Antropologia Biològica (Dpt Biologia Evolutiva, Ecologia i Ciències Ambientals), Facultat de Biologia and Institut de Biomedicina, University of Barcelona, Centro de Investigación Biomédica en Red de Salud Mental, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Aubry, Jean Michel" sort="Aubry, Jean Michel" uniqKey="Aubry J" first="Jean-Michel" last="Aubry">Jean-Michel Aubry</name><affiliation><nlm:affiliation>Department of Psychiatry, Mood Disorders Unit, Geneva University Hospitals, Geneva, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Backlund, Lena" sort="Backlund, Lena" uniqKey="Backlund L" first="Lena" last="Backlund">Lena Backlund</name><affiliation><nlm:affiliation>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden, and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Bhattacharjee, Abesh Kumar" sort="Bhattacharjee, Abesh Kumar" uniqKey="Bhattacharjee A" first="Abesh Kumar" last="Bhattacharjee">Abesh Kumar Bhattacharjee</name><affiliation><nlm:affiliation>Department of Psychiatry, University of California San Diego.</nlm:affiliation></affiliation></author><author><name sortKey="Bellivier, Frank" sort="Bellivier, Frank" uniqKey="Bellivier F" first="Frank" last="Bellivier">Frank Bellivier</name><affiliation><nlm:affiliation>Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche Scientifique 1144, Université Paris Diderot, Département de Psychiatrie et de Médecine Addictologique, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Saint-Louis-Lariboisière-F. Widal, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Benabarre, Antonio" sort="Benabarre, Antonio" uniqKey="Benabarre A" first="Antonio" last="Benabarre">Antonio Benabarre</name><affiliation><nlm:affiliation>Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red Salud Mental, Barcelona, Catalonia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Bengesser, Susanne" sort="Bengesser, Susanne" uniqKey="Bengesser S" first="Susanne" last="Bengesser">Susanne Bengesser</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Biernacka, Joanna M" sort="Biernacka, Joanna M" uniqKey="Biernacka J" first="Joanna M" last="Biernacka">Joanna M. Biernacka</name><affiliation><nlm:affiliation>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.</nlm:affiliation></affiliation></author><author><name sortKey="Birner, Armin" sort="Birner, Armin" uniqKey="Birner A" first="Armin" last="Birner">Armin Birner</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Brichant Petitjean, Clara" sort="Brichant Petitjean, Clara" uniqKey="Brichant Petitjean C" first="Clara" last="Brichant-Petitjean">Clara Brichant-Petitjean</name><affiliation><nlm:affiliation>Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche Scientifique 1144, Université Paris Diderot, Département de Psychiatrie et de Médecine Addictologique, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Saint-Louis-Lariboisière-F. Widal, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Cervantes, Pablo" sort="Cervantes, Pablo" uniqKey="Cervantes P" first="Pablo" last="Cervantes">Pablo Cervantes</name><affiliation><nlm:affiliation>The Neuromodulation Unit, McGill University Health Centre, Montreal, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Hsi Chung" sort="Chen, Hsi Chung" uniqKey="Chen H" first="Hsi-Chung" last="Chen">Hsi-Chung Chen</name><affiliation><nlm:affiliation>Department of Psychiatry and Center of Sleep Disorders, National Taiwan University Hospital, Taipei, Taiwan.</nlm:affiliation></affiliation></author><author><name sortKey="Chillotti, Caterina" sort="Chillotti, Caterina" uniqKey="Chillotti C" first="Caterina" last="Chillotti">Caterina Chillotti</name><affiliation><nlm:affiliation>Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Cichon, Sven" sort="Cichon, Sven" uniqKey="Cichon S" first="Sven" last="Cichon">Sven Cichon</name><affiliation><nlm:affiliation>Institute of Human Genetics and Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Cruceanu, Cristiana" sort="Cruceanu, Cristiana" uniqKey="Cruceanu C" first="Cristiana" last="Cruceanu">Cristiana Cruceanu</name><affiliation><nlm:affiliation>Douglas Mental Health University Institute, McGill University, Montreal, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Czerski, Piotr M" sort="Czerski, Piotr M" uniqKey="Czerski P" first="Piotr M" last="Czerski">Piotr M. Czerski</name><affiliation><nlm:affiliation>Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Dalkner, Nina" sort="Dalkner, Nina" uniqKey="Dalkner N" first="Nina" last="Dalkner">Nina Dalkner</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Dayer, Alexandre" sort="Dayer, Alexandre" uniqKey="Dayer A" first="Alexandre" last="Dayer">Alexandre Dayer</name><affiliation><nlm:affiliation>Department of Psychiatry, Mood Disorders Unit, Geneva University Hospitals, Geneva, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Del Zompo, Maria" sort="Del Zompo, Maria" uniqKey="Del Zompo M" first="Maria" last="Del Zompo">Maria Del Zompo</name><affiliation><nlm:affiliation>Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Depaulo, J Raymond" sort="Depaulo, J Raymond" uniqKey="Depaulo J" first="J Raymond" last="Depaulo">J Raymond Depaulo</name><affiliation><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Etain, Bruno" sort="Etain, Bruno" uniqKey="Etain B" first="Bruno" last="Étain">Bruno Étain</name><affiliation><nlm:affiliation>Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche Scientifique 1144, Université Paris Diderot, Département de Psychiatrie et de Médecine Addictologique, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Saint-Louis-Lariboisière-F. Widal, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Falkai, Peter" sort="Falkai, Peter" uniqKey="Falkai P" first="Peter" last="Falkai">Peter Falkai</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychotherapy, Ludwig-Maximilian University of Munich, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Forstner, Andreas J" sort="Forstner, Andreas J" uniqKey="Forstner A" first="Andreas J" last="Forstner">Andreas J. Forstner</name><affiliation><nlm:affiliation>Institute of Human Genetics and Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Frisen, Louise" sort="Frisen, Louise" uniqKey="Frisen L" first="Louise" last="Frisen">Louise Frisen</name><affiliation><nlm:affiliation>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden, and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Frye, Mark A" sort="Frye, Mark A" uniqKey="Frye M" first="Mark A" last="Frye">Mark A. Frye</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota.</nlm:affiliation></affiliation></author><author><name sortKey="Fullerton, Janice M" sort="Fullerton, Janice M" uniqKey="Fullerton J" first="Janice M" last="Fullerton">Janice M. Fullerton</name><affiliation><nlm:affiliation>Neuroscience Research Australia, Sydney, New South Wales, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Gard, Sebastien" sort="Gard, Sebastien" uniqKey="Gard S" first="Sébastien" last="Gard">Sébastien Gard</name><affiliation><nlm:affiliation>Service de Psychiatrie, Hôpital Charles Perrens, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Garnham, Julie S" sort="Garnham, Julie S" uniqKey="Garnham J" first="Julie S" last="Garnham">Julie S. Garnham</name><affiliation><nlm:affiliation>Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Goes, Fernando S" sort="Goes, Fernando S" uniqKey="Goes F" first="Fernando S" last="Goes">Fernando S. Goes</name><affiliation><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Grigoroiu Serbanescu, Maria" sort="Grigoroiu Serbanescu, Maria" uniqKey="Grigoroiu Serbanescu M" first="Maria" last="Grigoroiu-Serbanescu">Maria Grigoroiu-Serbanescu</name><affiliation><nlm:affiliation>Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania.</nlm:affiliation></affiliation></author><author><name sortKey="Grof, Paul" sort="Grof, Paul" uniqKey="Grof P" first="Paul" last="Grof">Paul Grof</name><affiliation><nlm:affiliation>Mood Disorders Center of Ottawa, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Hashimoto, Ryota" sort="Hashimoto, Ryota" uniqKey="Hashimoto R" first="Ryota" last="Hashimoto">Ryota Hashimoto</name><affiliation><nlm:affiliation>Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Osaka, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Hauser, Joanna" sort="Hauser, Joanna" uniqKey="Hauser J" first="Joanna" last="Hauser">Joanna Hauser</name><affiliation><nlm:affiliation>Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Herms, Stefan" sort="Herms, Stefan" uniqKey="Herms S" first="Stefan" last="Herms">Stefan Herms</name><affiliation><nlm:affiliation>Institute of Human Genetics and Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hoffmann, Per" sort="Hoffmann, Per" uniqKey="Hoffmann P" first="Per" last="Hoffmann">Per Hoffmann</name><affiliation><nlm:affiliation>Institute of Human Genetics and Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hofmann, Andrea" sort="Hofmann, Andrea" uniqKey="Hofmann A" first="Andrea" last="Hofmann">Andrea Hofmann</name><affiliation><nlm:affiliation>Institute of Human Genetics and Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Jamain, Stephane" sort="Jamain, Stephane" uniqKey="Jamain S" first="Stephane" last="Jamain">Stephane Jamain</name><affiliation><nlm:affiliation>Institut National de la Santé et de la Recherche Médicale Unité 955, Psychiatrie Translationnelle, Créteil, France.</nlm:affiliation></affiliation></author><author><name sortKey="Jimenez, Esther" sort="Jimenez, Esther" uniqKey="Jimenez E" first="Esther" last="Jiménez">Esther Jiménez</name><affiliation><nlm:affiliation>Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red Salud Mental, Barcelona, Catalonia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Kahn, Jean Pierre" sort="Kahn, Jean Pierre" uniqKey="Kahn J" first="Jean-Pierre" last="Kahn">Jean-Pierre Kahn</name><affiliation><nlm:affiliation>Service de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de Nancy, Université de Lorraine, Nancy, France.</nlm:affiliation></affiliation></author><author><name sortKey="Kassem, Layla" sort="Kassem, Layla" uniqKey="Kassem L" first="Layla" last="Kassem">Layla Kassem</name><affiliation><nlm:affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Kuo, Po Hsiu" sort="Kuo, Po Hsiu" uniqKey="Kuo P" first="Po-Hsiu" last="Kuo">Po-Hsiu Kuo</name><affiliation><nlm:affiliation>Department of Public Health and Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.</nlm:affiliation></affiliation></author><author><name sortKey="Kato, Tadafumi" sort="Kato, Tadafumi" uniqKey="Kato T" first="Tadafumi" last="Kato">Tadafumi Kato</name><affiliation><nlm:affiliation>Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Kelsoe, John" sort="Kelsoe, John" uniqKey="Kelsoe J" first="John" last="Kelsoe">John Kelsoe</name><affiliation><nlm:affiliation>Department of Psychiatry, University of California San Diego.</nlm:affiliation></affiliation></author><author><name sortKey="Kittel Schneider, Sarah" sort="Kittel Schneider, Sarah" uniqKey="Kittel Schneider S" first="Sarah" last="Kittel-Schneider">Sarah Kittel-Schneider</name><affiliation><nlm:affiliation>Department of Psychiatry, Psychosomatic Medicine, and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Kliwicki, Sebastian" sort="Kliwicki, Sebastian" uniqKey="Kliwicki S" first="Sebastian" last="Kliwicki">Sebastian Kliwicki</name><affiliation><nlm:affiliation>Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Konig, Barbara" sort="Konig, Barbara" uniqKey="Konig B" first="Barbara" last="König">Barbara König</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychotherapeutic Medicine, Landesklinikum Neunkirchen, Neunkirchen, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Kusumi, Ichiro" sort="Kusumi, Ichiro" uniqKey="Kusumi I" first="Ichiro" last="Kusumi">Ichiro Kusumi</name><affiliation><nlm:affiliation>Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Laje, Gonzalo" sort="Laje, Gonzalo" uniqKey="Laje G" first="Gonzalo" last="Laje">Gonzalo Laje</name><affiliation><nlm:affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Landen, Mikael" sort="Landen, Mikael" uniqKey="Landen M" first="Mikael" last="Landén">Mikael Landén</name><affiliation><nlm:affiliation>Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the Gothenburg University, Gothenburg, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Lavebratt, Catharina" sort="Lavebratt, Catharina" uniqKey="Lavebratt C" first="Catharina" last="Lavebratt">Catharina Lavebratt</name><affiliation><nlm:affiliation>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden, and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Leboyer, Marion" sort="Leboyer, Marion" uniqKey="Leboyer M" first="Marion" last="Leboyer">Marion Leboyer</name><affiliation><nlm:affiliation>Inserm U955, Translational Psychiatry Laboratory, Université Paris-Est-Créteil, Department of Psychiatry and Addictology of Mondor University Hospital, Assistance Publique-Hôpitaux de Paris, Hôpital Albert Chenevier-Henri Mondor, Pôle de Psychiatrie, Créteil, France.</nlm:affiliation></affiliation></author><author><name sortKey="Leckband, Susan G" sort="Leckband, Susan G" uniqKey="Leckband S" first="Susan G" last="Leckband">Susan G. Leckband</name><affiliation><nlm:affiliation>Department of Pharmacy, Veterans Affairs San Diego Healthcare System, San Diego, California.</nlm:affiliation></affiliation></author><author><name sortKey="Tortorella, Alfonso" sort="Tortorella, Alfonso" uniqKey="Tortorella A" first="Alfonso" last="Tortorella">Alfonso Tortorella</name><affiliation><nlm:affiliation>Department of Psychiatry, University of Perugia, Perugia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Manchia, Mirko" sort="Manchia, Mirko" uniqKey="Manchia M" first="Mirko" last="Manchia">Mirko Manchia</name><affiliation><nlm:affiliation>Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Martinsson, Lina" sort="Martinsson, Lina" uniqKey="Martinsson L" first="Lina" last="Martinsson">Lina Martinsson</name><affiliation><nlm:affiliation>Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Mccarthy, Michael J" sort="Mccarthy, Michael J" uniqKey="Mccarthy M" first="Michael J" last="Mccarthy">Michael J. Mccarthy</name><affiliation><nlm:affiliation>Department of Psychiatry, University of California San Diego.</nlm:affiliation></affiliation></author><author><name sortKey="Mcelroy, Susan" sort="Mcelroy, Susan" uniqKey="Mcelroy S" first="Susan" last="Mcelroy">Susan Mcelroy</name><affiliation><nlm:affiliation>Department of Psychiatry, Lindner Center of Hope and University of Cincinnati, Mason, Ohio.</nlm:affiliation></affiliation></author><author><name sortKey="Colom, Francesc" sort="Colom, Francesc" uniqKey="Colom F" first="Francesc" last="Colom">Francesc Colom</name><affiliation><nlm:affiliation>Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red Salud Mental, Barcelona, Catalonia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Mitjans, Marina" sort="Mitjans, Marina" uniqKey="Mitjans M" first="Marina" last="Mitjans">Marina Mitjans</name><affiliation><nlm:affiliation>Centro de Investigación Biomédica en Red de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Mondimore, Francis M" sort="Mondimore, Francis M" uniqKey="Mondimore F" first="Francis M" last="Mondimore">Francis M. Mondimore</name><affiliation><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Monteleone, Palmiero" sort="Monteleone, Palmiero" uniqKey="Monteleone P" first="Palmiero" last="Monteleone">Palmiero Monteleone</name><affiliation><nlm:affiliation>Neurosciences Section, Department of Medicine and Surgery, University of Salerno, Salerno, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Nievergelt, Caroline M" sort="Nievergelt, Caroline M" uniqKey="Nievergelt C" first="Caroline M" last="Nievergelt">Caroline M. Nievergelt</name><affiliation><nlm:affiliation>Department of Psychiatry, University of California San Diego.</nlm:affiliation></affiliation></author><author><name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M" last="Nöthen">Markus M. Nöthen</name><affiliation><nlm:affiliation>Institute of Human Genetics and Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Novak, Tomas" sort="Novak, Tomas" uniqKey="Novak T" first="Tomas" last="Novák">Tomas Novák</name><affiliation><nlm:affiliation>National Institute of Mental Health, Klecany, Czech Republic.</nlm:affiliation></affiliation></author><author><name sortKey="O Donovan, Claire" sort="O Donovan, Claire" uniqKey="O Donovan C" first="Claire" last="O'Donovan">Claire O'Donovan</name><affiliation><nlm:affiliation>Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Ozaki, Norio" sort="Ozaki, Norio" uniqKey="Ozaki N" first="Norio" last="Ozaki">Norio Ozaki</name><affiliation><nlm:affiliation>Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Osby, Urban" sort="Osby, Urban" uniqKey="Osby U" first="Urban" last="Ösby">Urban Ösby</name><affiliation><nlm:affiliation>Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Pfennig, Andrea" sort="Pfennig, Andrea" uniqKey="Pfennig A" first="Andrea" last="Pfennig">Andrea Pfennig</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Potash, James B" sort="Potash, James B" uniqKey="Potash J" first="James B" last="Potash">James B. Potash</name><affiliation><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Reif, Andreas" sort="Reif, Andreas" uniqKey="Reif A" first="Andreas" last="Reif">Andreas Reif</name><affiliation><nlm:affiliation>Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Reininghaus, Eva" sort="Reininghaus, Eva" uniqKey="Reininghaus E" first="Eva" last="Reininghaus">Eva Reininghaus</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Rouleau, Guy A" sort="Rouleau, Guy A" uniqKey="Rouleau G" first="Guy A" last="Rouleau">Guy A. Rouleau</name><affiliation><nlm:affiliation>Montreal Neurological Institute and Hospital, McGill University, Montreal, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Rybakowski, Janusz K" sort="Rybakowski, Janusz K" uniqKey="Rybakowski J" first="Janusz K" last="Rybakowski">Janusz K. Rybakowski</name><affiliation><nlm:affiliation>Department of Psychiatry, Psychosomatic Medicine, and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Schalling, Martin" sort="Schalling, Martin" uniqKey="Schalling M" first="Martin" last="Schalling">Martin Schalling</name><affiliation><nlm:affiliation>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden, and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Schofield, Peter R" sort="Schofield, Peter R" uniqKey="Schofield P" first="Peter R" last="Schofield">Peter R. Schofield</name><affiliation><nlm:affiliation>Neuroscience Research Australia, Sydney, New South Wales, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Schweizer, Barbara W" sort="Schweizer, Barbara W" uniqKey="Schweizer B" first="Barbara W" last="Schweizer">Barbara W. Schweizer</name><affiliation><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Severino, Giovanni" sort="Severino, Giovanni" uniqKey="Severino G" first="Giovanni" last="Severino">Giovanni Severino</name><affiliation><nlm:affiliation>Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Shilling, Paul D" sort="Shilling, Paul D" uniqKey="Shilling P" first="Paul D" last="Shilling">Paul D. Shilling</name><affiliation><nlm:affiliation>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden, and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Shimoda, Katzutaka" sort="Shimoda, Katzutaka" uniqKey="Shimoda K" first="Katzutaka" last="Shimoda">Katzutaka Shimoda</name><affiliation><nlm:affiliation>Department of Psychiatry, Dokkyo University School of Medicine, Mibu, Tochigi, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Simhandl, Christian" sort="Simhandl, Christian" uniqKey="Simhandl C" first="Christian" last="Simhandl">Christian Simhandl</name><affiliation><nlm:affiliation>Bipolar Center Wiener Neustadt, Sigmund Freud University, Medical Faculty, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Slaney, Claire M" sort="Slaney, Claire M" uniqKey="Slaney C" first="Claire M" last="Slaney">Claire M. Slaney</name><affiliation><nlm:affiliation>Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Squassina, Alessio" sort="Squassina, Alessio" uniqKey="Squassina A" first="Alessio" last="Squassina">Alessio Squassina</name><affiliation><nlm:affiliation>Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Stamm, Thomas" sort="Stamm, Thomas" uniqKey="Stamm T" first="Thomas" last="Stamm">Thomas Stamm</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Stopkova, Pavla" sort="Stopkova, Pavla" uniqKey="Stopkova P" first="Pavla" last="Stopkova">Pavla Stopkova</name><affiliation><nlm:affiliation>National Institute of Mental Health, Klecany, Czech Republic.</nlm:affiliation></affiliation></author><author><name sortKey="Maj, Mario" sort="Maj, Mario" uniqKey="Maj M" first="Mario" last="Maj">Mario Maj</name><affiliation><nlm:affiliation>Department of Psychiatry, Second University of Naples, Naples, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Turecki, Gustavo" sort="Turecki, Gustavo" uniqKey="Turecki G" first="Gustavo" last="Turecki">Gustavo Turecki</name><affiliation><nlm:affiliation>Douglas Mental Health University Institute, McGill University, Montreal, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Vieta, Eduard" sort="Vieta, Eduard" uniqKey="Vieta E" first="Eduard" last="Vieta">Eduard Vieta</name><affiliation><nlm:affiliation>Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red Salud Mental, Barcelona, Catalonia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Volkert, Julia" sort="Volkert, Julia" uniqKey="Volkert J" first="Julia" last="Volkert">Julia Volkert</name><affiliation><nlm:affiliation>Department of Psychiatry, Psychosomatic Medicine, and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Witt, Stephanie" sort="Witt, Stephanie" uniqKey="Witt S" first="Stephanie" last="Witt">Stephanie Witt</name><affiliation><nlm:affiliation>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Wright, Adam" sort="Wright, Adam" uniqKey="Wright A" first="Adam" last="Wright">Adam Wright</name><affiliation><nlm:affiliation>School of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, New South Wales, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Zandi, Peter P" sort="Zandi, Peter P" uniqKey="Zandi P" first="Peter P" last="Zandi">Peter P. Zandi</name><affiliation><nlm:affiliation>Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Mitchell, Philip B" sort="Mitchell, Philip B" uniqKey="Mitchell P" first="Philip B" last="Mitchell">Philip B. Mitchell</name><affiliation><nlm:affiliation>School of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, New South Wales, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Bauer, Michael" sort="Bauer, Michael" uniqKey="Bauer M" first="Michael" last="Bauer">Michael Bauer</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Alda, Martin" sort="Alda, Martin" uniqKey="Alda M" first="Martin" last="Alda">Martin Alda</name><affiliation><nlm:affiliation>Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Rietschel, Marcella" sort="Rietschel, Marcella" uniqKey="Rietschel M" first="Marcella" last="Rietschel">Marcella Rietschel</name><affiliation><nlm:affiliation>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Mcmahon, Francis J" sort="Mcmahon, Francis J" uniqKey="Mcmahon F" first="Francis J" last="Mcmahon">Francis J. Mcmahon</name><affiliation><nlm:affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Schulze, Thomas G" sort="Schulze, Thomas G" uniqKey="Schulze T" first="Thomas G" last="Schulze">Thomas G. Schulze</name><affiliation><nlm:affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Baune, Bernhard T" sort="Baune, Bernhard T" uniqKey="Baune B" first="Bernhard T" last="Baune">Bernhard T. Baune</name><affiliation><nlm:affiliation>Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, South Australia, Australia.</nlm:affiliation></affiliation></author></analytic><series><title level="j">JAMA psychiatry</title><idno type="eISSN">2168-6238</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lithium is a first-line mood stabilizer for the treatment of bipolar affective disorder (BPAD). However, the efficacy of lithium varies widely, with a nonresponse rate of up to 30%. Biological response markers are lacking. Genetic factors are thought to mediate treatment response to lithium, and there is a previously reported genetic overlap between BPAD and schizophrenia (SCZ).</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">29121268</PMID><DateCreated><Year>2017</Year><Month>11</Month><Day>09</Day></DateCreated><DateRevised><Year>2017</Year><Month>11</Month><Day>09</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2168-6238</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2017</Year><Month>Nov</Month><Day>09</Day></PubDate></JournalIssue><Title>JAMA psychiatry</Title><ISOAbbreviation>JAMA Psychiatry</ISOAbbreviation></Journal><ArticleTitle>Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1001/jamapsychiatry.2017.3433</ELocationID><Abstract><AbstractText Label="Importance" NlmCategory="UNASSIGNED">Lithium is a first-line mood stabilizer for the treatment of bipolar affective disorder (BPAD). However, the efficacy of lithium varies widely, with a nonresponse rate of up to 30%. Biological response markers are lacking. Genetic factors are thought to mediate treatment response to lithium, and there is a previously reported genetic overlap between BPAD and schizophrenia (SCZ).</AbstractText><AbstractText Label="Objectives" NlmCategory="UNASSIGNED">To test whether a polygenic score for SCZ is associated with treatment response to lithium in BPAD and to explore the potential molecular underpinnings of this association.</AbstractText><AbstractText Label="Design, Setting, and Participants" NlmCategory="UNASSIGNED">A total of 2586 patients with BPAD who had undergone lithium treatment were genotyped and assessed for long-term response to treatment between 2008 and 2013. Weighted SCZ polygenic scores were computed at different P value thresholds using summary statistics from an international multicenter genome-wide association study (GWAS) of 36 989 individuals with SCZ and genotype data from patients with BPAD from the Consortium on Lithium Genetics. For functional exploration, a cross-trait meta-GWAS and pathway analysis was performed, combining GWAS summary statistics on SCZ and response to treatment with lithium. Data analysis was performed from September 2016 to February 2017.</AbstractText><AbstractText Label="Main Outcomes and Measures" NlmCategory="UNASSIGNED">Treatment response to lithium was defined on both the categorical and continuous scales using the Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder score. The effect measures include odds ratios and the proportion of variance explained.</AbstractText><AbstractText Label="Results" NlmCategory="UNASSIGNED">Of the 2586 patients in the study (mean [SD] age, 47.2 [13.9] years), 1478 were women and 1108 were men. The polygenic score for SCZ was inversely associated with lithium treatment response in the categorical outcome, at a threshold P < 5 × 10-2. Patients with BPAD who had a low polygenic load for SCZ responded better to lithium, with odds ratios for lithium response ranging from 3.46 (95% CI, 1.42-8.41) at the first decile to 2.03 (95% CI, 0.86-4.81) at the ninth decile, compared with the patients in the 10th decile of SCZ risk. In the cross-trait meta-GWAS, 15 genetic loci that may have overlapping effects on lithium treatment response and susceptibility to SCZ were identified. Functional pathway and network analysis of these loci point to the HLA antigen complex and inflammatory cytokines.</AbstractText><AbstractText Label="Conclusions and Relevance" NlmCategory="UNASSIGNED">This study provides evidence for a negative association between high genetic loading for SCZ and poor response to lithium in patients with BPAD. These results suggest the potential for translational research aimed at personalized prescribing of lithium.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><CollectiveName>International Consortium on Lithium Genetics (ConLi+Gen)</CollectiveName></Author><Author ValidYN="Y"><LastName>Amare</LastName><ForeName>Azmeraw T</ForeName><Initials>AT</Initials><AffiliationInfo><Affiliation>Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, South Australia, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schubert</LastName><ForeName>Klaus Oliver</ForeName><Initials>KO</Initials><AffiliationInfo><Affiliation>Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, South Australia, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Northern Adelaide Local Health Network, Mental Health Services, Adelaide, South Australia, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hou</LastName><ForeName>Liping</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Clark</LastName><ForeName>Scott R</ForeName><Initials>SR</Initials><AffiliationInfo><Affiliation>Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, South Australia, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Papiol</LastName><ForeName>Sergi</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig-Maximilian University of Munich, Munich, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Psychiatry and Psychotherapy, Ludwig-Maximilian University of Munich, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Heilbronner</LastName><ForeName>Urs</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Institute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig-Maximilian University of Munich, Munich, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August University Göttingen, Göttingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Degenhardt</LastName><ForeName>Franziska</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Institute of Human Genetics and Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tekola-Ayele</LastName><ForeName>Fasil</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hsu</LastName><ForeName>Yi-Hsiang</ForeName><Initials>YH</Initials><AffiliationInfo><Affiliation>Hebrew SeniorLife Institute for Aging Research, Harvard Medical School, Boston, Massachusetts.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Program for Quantitative Genomics, Harvard School of Public Health, Boston, Massachusetts.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shekhtman</LastName><ForeName>Tatyana</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, University of California San Diego.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Adli</LastName><ForeName>Mazda</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Akula</LastName><ForeName>Nirmala</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Akiyama</LastName><ForeName>Kazufumi</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Biological Psychiatry and Neuroscience, Dokkyo Medical University School of Medicine, Mibu, Tochigi, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ardau</LastName><ForeName>Raffaella</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arias</LastName><ForeName>Bárbara</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Unitat de Zoologia i Antropologia Biològica (Dpt Biologia Evolutiva, Ecologia i Ciències Ambientals), Facultat de Biologia and Institut de Biomedicina, University of Barcelona, Centro de Investigación Biomédica en Red de Salud Mental, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aubry</LastName><ForeName>Jean-Michel</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Mood Disorders Unit, Geneva University Hospitals, Geneva, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Backlund</LastName><ForeName>Lena</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden, and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bhattacharjee</LastName><ForeName>Abesh Kumar</ForeName><Initials>AK</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, University of California San Diego.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bellivier</LastName><ForeName>Frank</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche Scientifique 1144, Université Paris Diderot, Département de Psychiatrie et de Médecine Addictologique, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Saint-Louis-Lariboisière-F. Widal, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Benabarre</LastName><ForeName>Antonio</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red Salud Mental, Barcelona, Catalonia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bengesser</LastName><ForeName>Susanne</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Biernacka</LastName><ForeName>Joanna M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Birner</LastName><ForeName>Armin</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brichant-Petitjean</LastName><ForeName>Clara</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche Scientifique 1144, Université Paris Diderot, Département de Psychiatrie et de Médecine Addictologique, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Saint-Louis-Lariboisière-F. Widal, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cervantes</LastName><ForeName>Pablo</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>The Neuromodulation Unit, McGill University Health Centre, Montreal, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Hsi-Chung</ForeName><Initials>HC</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Center of Sleep Disorders, National Taiwan University Hospital, Taipei, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chillotti</LastName><ForeName>Caterina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cichon</LastName><ForeName>Sven</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute of Human Genetics and Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Human Genomics Research Group, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cruceanu</LastName><ForeName>Cristiana</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Douglas Mental Health University Institute, McGill University, Montreal, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Czerski</LastName><ForeName>Piotr M</ForeName><Initials>PM</Initials><AffiliationInfo><Affiliation>Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dalkner</LastName><ForeName>Nina</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dayer</LastName><ForeName>Alexandre</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Mood Disorders Unit, Geneva University Hospitals, Geneva, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Del Zompo</LastName><ForeName>Maria</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>DePaulo</LastName><ForeName>J Raymond</ForeName><Initials>JR</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Étain</LastName><ForeName>Bruno</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche Scientifique 1144, Université Paris Diderot, Département de Psychiatrie et de Médecine Addictologique, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Saint-Louis-Lariboisière-F. Widal, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Falkai</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Psychotherapy, Ludwig-Maximilian University of Munich, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Forstner</LastName><ForeName>Andreas J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>Institute of Human Genetics and Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Human Genomics Research Group, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Psychiatry, University of Basel, Basel, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Frisen</LastName><ForeName>Louise</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden, and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Frye</LastName><ForeName>Mark A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fullerton</LastName><ForeName>Janice M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Neuroscience Research Australia, Sydney, New South Wales, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gard</LastName><ForeName>Sébastien</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Service de Psychiatrie, Hôpital Charles Perrens, Bordeaux, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Garnham</LastName><ForeName>Julie S</ForeName><Initials>JS</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goes</LastName><ForeName>Fernando S</ForeName><Initials>FS</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grigoroiu-Serbanescu</LastName><ForeName>Maria</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grof</LastName><ForeName>Paul</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Mood Disorders Center of Ottawa, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hashimoto</LastName><ForeName>Ryota</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Osaka, Japan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hauser</LastName><ForeName>Joanna</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Herms</LastName><ForeName>Stefan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute of Human Genetics and Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Human Genomics Research Group, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hoffmann</LastName><ForeName>Per</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Institute of Human Genetics and Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Human Genomics Research Group, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hofmann</LastName><ForeName>Andrea</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute of Human Genetics and Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jamain</LastName><ForeName>Stephane</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institut National de la Santé et de la Recherche Médicale Unité 955, Psychiatrie Translationnelle, Créteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jiménez</LastName><ForeName>Esther</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red Salud Mental, Barcelona, Catalonia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kahn</LastName><ForeName>Jean-Pierre</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Service de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de Nancy, Université de Lorraine, Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kassem</LastName><ForeName>Layla</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kuo</LastName><ForeName>Po-Hsiu</ForeName><Initials>PH</Initials><AffiliationInfo><Affiliation>Department of Public Health and Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kato</LastName><ForeName>Tadafumi</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kelsoe</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, University of California San Diego.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kittel-Schneider</LastName><ForeName>Sarah</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Psychosomatic Medicine, and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kliwicki</LastName><ForeName>Sebastian</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>König</LastName><ForeName>Barbara</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Psychotherapeutic Medicine, Landesklinikum Neunkirchen, Neunkirchen, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kusumi</LastName><ForeName>Ichiro</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Laje</LastName><ForeName>Gonzalo</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Landén</LastName><ForeName>Mikael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the Gothenburg University, Gothenburg, Sweden.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lavebratt</LastName><ForeName>Catharina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden, and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leboyer</LastName><ForeName>Marion</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Inserm U955, Translational Psychiatry Laboratory, Université Paris-Est-Créteil, Department of Psychiatry and Addictology of Mondor University Hospital, Assistance Publique-Hôpitaux de Paris, Hôpital Albert Chenevier-Henri Mondor, Pôle de Psychiatrie, Créteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leckband</LastName><ForeName>Susan G</ForeName><Initials>SG</Initials><AffiliationInfo><Affiliation>Department of Pharmacy, Veterans Affairs San Diego Healthcare System, San Diego, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tortorella</LastName><ForeName>Alfonso</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, University of Perugia, Perugia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Manchia</LastName><ForeName>Mirko</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martinsson</LastName><ForeName>Lina</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McCarthy</LastName><ForeName>Michael J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, University of California San Diego.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Psychiatry, Veterans Affairs San Diego Healthcare System, San Diego, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McElroy</LastName><ForeName>Susan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Lindner Center of Hope and University of Cincinnati, Mason, Ohio.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Colom</LastName><ForeName>Francesc</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red Salud Mental, Barcelona, Catalonia, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Mental Health Research Group, IMIM-Hospital del Mar, Barcelona, Catalonia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mitjans</LastName><ForeName>Marina</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Centro de Investigación Biomédica en Red de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mondimore</LastName><ForeName>Francis M</ForeName><Initials>FM</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Monteleone</LastName><ForeName>Palmiero</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Neurosciences Section, Department of Medicine and Surgery, University of Salerno, Salerno, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Psychiatry, Second University of Naples, Naples, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nievergelt</LastName><ForeName>Caroline M</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, University of California San Diego.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nöthen</LastName><ForeName>Markus M</ForeName><Initials>MM</Initials><AffiliationInfo><Affiliation>Institute of Human Genetics and Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Novák</LastName><ForeName>Tomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>National Institute of Mental Health, Klecany, Czech Republic.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>O'Donovan</LastName><ForeName>Claire</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ozaki</LastName><ForeName>Norio</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ösby</LastName><ForeName>Urban</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pfennig</LastName><ForeName>Andrea</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Potash</LastName><ForeName>James B</ForeName><Initials>JB</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reif</LastName><ForeName>Andreas</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reininghaus</LastName><ForeName>Eva</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rouleau</LastName><ForeName>Guy A</ForeName><Initials>GA</Initials><AffiliationInfo><Affiliation>Montreal Neurological Institute and Hospital, McGill University, Montreal, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rybakowski</LastName><ForeName>Janusz K</ForeName><Initials>JK</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Psychosomatic 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W</ForeName><Initials>BW</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Severino</LastName><ForeName>Giovanni</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shilling</LastName><ForeName>Paul D</ForeName><Initials>PD</Initials><AffiliationInfo><Affiliation>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden, and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shimoda</LastName><ForeName>Katzutaka</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Dokkyo University School of Medicine, Mibu, Tochigi, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Simhandl</LastName><ForeName>Christian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Bipolar Center Wiener Neustadt, Sigmund Freud University, Medical Faculty, Vienna, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Slaney</LastName><ForeName>Claire M</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Squassina</LastName><ForeName>Alessio</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stamm</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stopkova</LastName><ForeName>Pavla</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>National Institute of Mental Health, Klecany, Czech Republic.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maj</LastName><ForeName>Mario</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Second University of Naples, Naples, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Turecki</LastName><ForeName>Gustavo</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Douglas Mental Health University Institute, McGill University, Montreal, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vieta</LastName><ForeName>Eduard</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red Salud Mental, Barcelona, Catalonia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Volkert</LastName><ForeName>Julia</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Psychosomatic Medicine, and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Witt</LastName><ForeName>Stephanie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wright</LastName><ForeName>Adam</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>School of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, New South Wales, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zandi</LastName><ForeName>Peter P</ForeName><Initials>PP</Initials><AffiliationInfo><Affiliation>Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mitchell</LastName><ForeName>Philip B</ForeName><Initials>PB</Initials><AffiliationInfo><Affiliation>School of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, New South Wales, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bauer</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alda</LastName><ForeName>Martin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rietschel</LastName><ForeName>Marcella</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McMahon</LastName><ForeName>Francis J</ForeName><Initials>FJ</Initials><AffiliationInfo><Affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schulze</LastName><ForeName>Thomas G</ForeName><Initials>TG</Initials><AffiliationInfo><Affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig-Maximilian University of Munich, Munich, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August University Göttingen, Göttingen, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baune</LastName><ForeName>Bernhard T</ForeName><Initials>BT</Initials><AffiliationInfo><Affiliation>Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, South Australia, Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>11</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>JAMA Psychiatry</MedlineTA><NlmUniqueID>101589550</NlmUniqueID><ISSNLinking>2168-622X</ISSNLinking></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>11</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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