Position paper: The potential role of optical biopsy in the study and diagnosis of environmental enteric dysfunction.
Identifieur interne : 000009 ( PubMed/Corpus ); précédent : 000008; suivant : 000010Position paper: The potential role of optical biopsy in the study and diagnosis of environmental enteric dysfunction.
Auteurs : Alex J. Thompson ; Michael Hughes ; Salzitsa Anastasova ; Laurie S. Conklin ; Tudor Thomas ; Cadman Leggett ; William A. Faubion ; Thomas J. Miller ; Peter Delaney ; François Lacombe ; Sacha Loiseau ; Alexander Meining ; Rebecca Richards-Kortum ; Guillermo J. Tearney ; Paul Kelly ; Guang-Zhong YangSource :
- Nature reviews. Gastroenterology & hepatology [ 1759-5053 ] ; 2017.
Abstract
Environmental enteric dysfunction (EED) is a disease of the small intestine affecting children and adults in low and middle income countries. Arising as a consequence of repeated infections, gut inflammation results in impaired intestinal absorptive and barrier function, leading to poor nutrient uptake and ultimately to stunting and other developmental limitations. Progress towards new biomarkers and interventions for EED is hampered by the practical and ethical difficulties of cross-validation with the gold standard of biopsy and histology. Optical biopsy techniques - which can provide minimally invasive or noninvasive alternatives to biopsy - could offer other routes to validation and could potentially be used as point-of-care tests among the general population. This Consensus Statement identifies and reviews the most promising candidate optical biopsy technologies for applications in EED, critically assesses them against criteria identified for successful deployment in developing world settings, and proposes further lines of enquiry. Importantly, many of the techniques discussed could also be adapted to monitor the impaired intestinal barrier in other settings such as IBD, autoimmune enteropathies, coeliac disease, graft-versus-host disease, small intestinal transplantation or critical care.
DOI: 10.1038/nrgastro.2017.147
PubMed: 29139480
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Thompson</name><affiliation><nlm:affiliation>Hamlyn Centre for Robotic Surgery, Bessemer Building, Imperial College London, South Kensington, London, SW7 2AZ, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Hughes, Michael" sort="Hughes, Michael" uniqKey="Hughes M" first="Michael" last="Hughes">Michael Hughes</name><affiliation><nlm:affiliation>Hamlyn Centre for Robotic Surgery, Bessemer Building, Imperial College London, South Kensington, London, SW7 2AZ, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Anastasova, Salzitsa" sort="Anastasova, Salzitsa" uniqKey="Anastasova S" first="Salzitsa" last="Anastasova">Salzitsa Anastasova</name><affiliation><nlm:affiliation>Hamlyn Centre for Robotic Surgery, Bessemer Building, Imperial College London, South Kensington, London, SW7 2AZ, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Conklin, Laurie S" sort="Conklin, Laurie S" uniqKey="Conklin L" first="Laurie S" last="Conklin">Laurie S. Conklin</name><affiliation><nlm:affiliation>Division of Gastroenterology, Hepatology, and Nutrition, Children's National Health Systems, 111 Michigan Avenue, NW, Washington District of Columbia 20010, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Thomas, Tudor" sort="Thomas, Tudor" uniqKey="Thomas T" first="Tudor" last="Thomas">Tudor Thomas</name><affiliation><nlm:affiliation>Olympus Surgical Technologies Europe, Fortran Road, Cardiff, CF3 0LT, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Leggett, Cadman" sort="Leggett, Cadman" uniqKey="Leggett C" first="Cadman" last="Leggett">Cadman Leggett</name><affiliation><nlm:affiliation>Division of Gastroenterology and Hepatology, Mayo College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Faubion, William A" sort="Faubion, William A" uniqKey="Faubion W" first="William A" last="Faubion">William A. Faubion</name><affiliation><nlm:affiliation>Division of Gastroenterology and Hepatology, Mayo College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Miller, Thomas J" sort="Miller, Thomas J" uniqKey="Miller T" first="Thomas J" last="Miller">Thomas J. Miller</name><affiliation><nlm:affiliation>GreyBird Ventures, 31 Pond View Lane, Concord, Massachusetts 01742, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Delaney, Peter" sort="Delaney, Peter" uniqKey="Delaney P" first="Peter" last="Delaney">Peter Delaney</name><affiliation><nlm:affiliation>OptiScan, 16 Miles Street, Mulgrave, Victoria 3170, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Lacombe, Francois" sort="Lacombe, Francois" uniqKey="Lacombe F" first="François" last="Lacombe">François Lacombe</name><affiliation><nlm:affiliation>Mauna Kea Technologies, 9 rue d'Enghien, 75010 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Loiseau, Sacha" sort="Loiseau, Sacha" uniqKey="Loiseau S" first="Sacha" last="Loiseau">Sacha Loiseau</name><affiliation><nlm:affiliation>Mauna Kea Technologies, 9 rue d'Enghien, 75010 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Meining, Alexander" sort="Meining, Alexander" uniqKey="Meining A" first="Alexander" last="Meining">Alexander Meining</name><affiliation><nlm:affiliation>Department of Internal Medicine I, Ulm University, Albert-Einstein-Allee 23, 89081 Ulm, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Richards Kortum, Rebecca" sort="Richards Kortum, Rebecca" uniqKey="Richards Kortum R" first="Rebecca" last="Richards-Kortum">Rebecca Richards-Kortum</name><affiliation><nlm:affiliation>Department of Bioengineering, Rice University, 6500 Main Street, Suite 1030, Houston, Texas 77030, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Tearney, Guillermo J" sort="Tearney, Guillermo J" uniqKey="Tearney G" first="Guillermo J" last="Tearney">Guillermo J. Tearney</name><affiliation><nlm:affiliation>Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kelly, Paul" sort="Kelly, Paul" uniqKey="Kelly P" first="Paul" last="Kelly">Paul Kelly</name><affiliation><nlm:affiliation>Blizard Institute, Barts and The London School of Medicine, Queen Mary University of London, 4 Newark Street, London, E1 2AT, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Guang Zhong" sort="Yang, Guang Zhong" uniqKey="Yang G" first="Guang-Zhong" last="Yang">Guang-Zhong Yang</name><affiliation><nlm:affiliation>Hamlyn Centre for Robotic Surgery, Bessemer Building, Imperial College London, South Kensington, London, SW7 2AZ, UK.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:29139480</idno><idno type="pmid">29139480</idno><idno type="doi">10.1038/nrgastro.2017.147</idno><idno type="wicri:Area/PubMed/Corpus">000009</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000009</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Position paper: The potential role of optical biopsy in the study and diagnosis of environmental enteric dysfunction.</title><author><name sortKey="Thompson, Alex J" sort="Thompson, Alex J" uniqKey="Thompson A" first="Alex J" last="Thompson">Alex J. Thompson</name><affiliation><nlm:affiliation>Hamlyn Centre for Robotic Surgery, Bessemer Building, Imperial College London, South Kensington, London, SW7 2AZ, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Hughes, Michael" sort="Hughes, Michael" uniqKey="Hughes M" first="Michael" last="Hughes">Michael Hughes</name><affiliation><nlm:affiliation>Hamlyn Centre for Robotic Surgery, Bessemer Building, Imperial College London, South Kensington, London, SW7 2AZ, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Anastasova, Salzitsa" sort="Anastasova, Salzitsa" uniqKey="Anastasova S" first="Salzitsa" last="Anastasova">Salzitsa Anastasova</name><affiliation><nlm:affiliation>Hamlyn Centre for Robotic Surgery, Bessemer Building, Imperial College London, South Kensington, London, SW7 2AZ, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Conklin, Laurie S" sort="Conklin, Laurie S" uniqKey="Conklin L" first="Laurie S" last="Conklin">Laurie S. Conklin</name><affiliation><nlm:affiliation>Division of Gastroenterology, Hepatology, and Nutrition, Children's National Health Systems, 111 Michigan Avenue, NW, Washington District of Columbia 20010, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Thomas, Tudor" sort="Thomas, Tudor" uniqKey="Thomas T" first="Tudor" last="Thomas">Tudor Thomas</name><affiliation><nlm:affiliation>Olympus Surgical Technologies Europe, Fortran Road, Cardiff, CF3 0LT, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Leggett, Cadman" sort="Leggett, Cadman" uniqKey="Leggett C" first="Cadman" last="Leggett">Cadman Leggett</name><affiliation><nlm:affiliation>Division of Gastroenterology and Hepatology, Mayo College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Faubion, William A" sort="Faubion, William A" uniqKey="Faubion W" first="William A" last="Faubion">William A. Faubion</name><affiliation><nlm:affiliation>Division of Gastroenterology and Hepatology, Mayo College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Miller, Thomas J" sort="Miller, Thomas J" uniqKey="Miller T" first="Thomas J" last="Miller">Thomas J. Miller</name><affiliation><nlm:affiliation>GreyBird Ventures, 31 Pond View Lane, Concord, Massachusetts 01742, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Delaney, Peter" sort="Delaney, Peter" uniqKey="Delaney P" first="Peter" last="Delaney">Peter Delaney</name><affiliation><nlm:affiliation>OptiScan, 16 Miles Street, Mulgrave, Victoria 3170, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Lacombe, Francois" sort="Lacombe, Francois" uniqKey="Lacombe F" first="François" last="Lacombe">François Lacombe</name><affiliation><nlm:affiliation>Mauna Kea Technologies, 9 rue d'Enghien, 75010 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Loiseau, Sacha" sort="Loiseau, Sacha" uniqKey="Loiseau S" first="Sacha" last="Loiseau">Sacha Loiseau</name><affiliation><nlm:affiliation>Mauna Kea Technologies, 9 rue d'Enghien, 75010 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Meining, Alexander" sort="Meining, Alexander" uniqKey="Meining A" first="Alexander" last="Meining">Alexander Meining</name><affiliation><nlm:affiliation>Department of Internal Medicine I, Ulm University, Albert-Einstein-Allee 23, 89081 Ulm, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Richards Kortum, Rebecca" sort="Richards Kortum, Rebecca" uniqKey="Richards Kortum R" first="Rebecca" last="Richards-Kortum">Rebecca Richards-Kortum</name><affiliation><nlm:affiliation>Department of Bioengineering, Rice University, 6500 Main Street, Suite 1030, Houston, Texas 77030, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Tearney, Guillermo J" sort="Tearney, Guillermo J" uniqKey="Tearney G" first="Guillermo J" last="Tearney">Guillermo J. Tearney</name><affiliation><nlm:affiliation>Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kelly, Paul" sort="Kelly, Paul" uniqKey="Kelly P" first="Paul" last="Kelly">Paul Kelly</name><affiliation><nlm:affiliation>Blizard Institute, Barts and The London School of Medicine, Queen Mary University of London, 4 Newark Street, London, E1 2AT, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Guang Zhong" sort="Yang, Guang Zhong" uniqKey="Yang G" first="Guang-Zhong" last="Yang">Guang-Zhong Yang</name><affiliation><nlm:affiliation>Hamlyn Centre for Robotic Surgery, Bessemer Building, Imperial College London, South Kensington, London, SW7 2AZ, UK.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Nature reviews. Gastroenterology & hepatology</title><idno type="eISSN">1759-5053</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Environmental enteric dysfunction (EED) is a disease of the small intestine affecting children and adults in low and middle income countries. Arising as a consequence of repeated infections, gut inflammation results in impaired intestinal absorptive and barrier function, leading to poor nutrient uptake and ultimately to stunting and other developmental limitations. Progress towards new biomarkers and interventions for EED is hampered by the practical and ethical difficulties of cross-validation with the gold standard of biopsy and histology. Optical biopsy techniques - which can provide minimally invasive or noninvasive alternatives to biopsy - could offer other routes to validation and could potentially be used as point-of-care tests among the general population. This Consensus Statement identifies and reviews the most promising candidate optical biopsy technologies for applications in EED, critically assesses them against criteria identified for successful deployment in developing world settings, and proposes further lines of enquiry. Importantly, many of the techniques discussed could also be adapted to monitor the impaired intestinal barrier in other settings such as IBD, autoimmune enteropathies, coeliac disease, graft-versus-host disease, small intestinal transplantation or critical care.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">29139480</PMID><DateCreated><Year>2017</Year><Month>11</Month><Day>15</Day></DateCreated><DateRevised><Year>2017</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1759-5053</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2017</Year><Month>Nov</Month><Day>15</Day></PubDate></JournalIssue><Title>Nature reviews. Gastroenterology & hepatology</Title><ISOAbbreviation>Nat Rev Gastroenterol Hepatol</ISOAbbreviation></Journal><ArticleTitle>Position paper: The potential role of optical biopsy in the study and diagnosis of environmental enteric dysfunction.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1038/nrgastro.2017.147</ELocationID><Abstract><AbstractText>Environmental enteric dysfunction (EED) is a disease of the small intestine affecting children and adults in low and middle income countries. Arising as a consequence of repeated infections, gut inflammation results in impaired intestinal absorptive and barrier function, leading to poor nutrient uptake and ultimately to stunting and other developmental limitations. Progress towards new biomarkers and interventions for EED is hampered by the practical and ethical difficulties of cross-validation with the gold standard of biopsy and histology. Optical biopsy techniques - which can provide minimally invasive or noninvasive alternatives to biopsy - could offer other routes to validation and could potentially be used as point-of-care tests among the general population. This Consensus Statement identifies and reviews the most promising candidate optical biopsy technologies for applications in EED, critically assesses them against criteria identified for successful deployment in developing world settings, and proposes further lines of enquiry. Importantly, many of the techniques discussed could also be adapted to monitor the impaired intestinal barrier in other settings such as IBD, autoimmune enteropathies, coeliac disease, graft-versus-host disease, small intestinal transplantation or critical care.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Thompson</LastName><ForeName>Alex J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>Hamlyn Centre for Robotic Surgery, Bessemer Building, Imperial College London, South Kensington, London, SW7 2AZ, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Surgical Innovation Centre, Paterson Building, St Mary's Hospital, Imperial College London, South Wharf Road, London, W2 1NY, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hughes</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Hamlyn Centre for Robotic Surgery, Bessemer Building, Imperial College London, South Kensington, London, SW7 2AZ, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Applied Optics Group, School of Physical Sciences, Ingram Building, University of Kent, Canterbury, Kent, CT2 7NH, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Anastasova</LastName><ForeName>Salzitsa</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Hamlyn Centre for Robotic Surgery, Bessemer Building, Imperial College London, South Kensington, London, SW7 2AZ, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Conklin</LastName><ForeName>Laurie S</ForeName><Initials>LS</Initials><AffiliationInfo><Affiliation>Division of Gastroenterology, Hepatology, and Nutrition, Children's National Health Systems, 111 Michigan Avenue, NW, Washington District of Columbia 20010, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thomas</LastName><ForeName>Tudor</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Olympus Surgical Technologies Europe, Fortran Road, Cardiff, CF3 0LT, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leggett</LastName><ForeName>Cadman</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Division of Gastroenterology and Hepatology, Mayo College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Faubion</LastName><ForeName>William A</ForeName><Initials>WA</Initials><AffiliationInfo><Affiliation>Division of Gastroenterology and Hepatology, Mayo College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Miller</LastName><ForeName>Thomas J</ForeName><Initials>TJ</Initials><AffiliationInfo><Affiliation>GreyBird Ventures, 31 Pond View Lane, Concord, Massachusetts 01742, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Delaney</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>OptiScan, 16 Miles Street, Mulgrave, Victoria 3170, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lacombe</LastName><ForeName>François</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Mauna Kea Technologies, 9 rue d'Enghien, 75010 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Loiseau</LastName><ForeName>Sacha</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Mauna Kea Technologies, 9 rue d'Enghien, 75010 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meining</LastName><ForeName>Alexander</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine I, Ulm University, Albert-Einstein-Allee 23, 89081 Ulm, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Richards-Kortum</LastName><ForeName>Rebecca</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Bioengineering, Rice University, 6500 Main Street, Suite 1030, Houston, Texas 77030, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tearney</LastName><ForeName>Guillermo J</ForeName><Initials>GJ</Initials><AffiliationInfo><Affiliation>Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kelly</LastName><ForeName>Paul</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Blizard Institute, Barts and The London School of Medicine, Queen Mary University of London, 4 Newark Street, London, E1 2AT, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Tropical Gastroenterology and Nutrition group, University of Zambia School of Medicine, Nationalist Road, Lusaka, Zambia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Guang-Zhong</ForeName><Initials>GZ</Initials><AffiliationInfo><Affiliation>Hamlyn Centre for Robotic Surgery, Bessemer Building, Imperial College London, South Kensington, London, SW7 2AZ, UK.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>11</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Nat Rev Gastroenterol Hepatol</MedlineTA><NlmUniqueID>101500079</NlmUniqueID><ISSNLinking>1759-5045</ISSNLinking></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>11</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>11</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>11</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29139480</ArticleId><ArticleId IdType="pii">nrgastro.2017.147</ArticleId><ArticleId IdType="doi">10.1038/nrgastro.2017.147</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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