A vision and strategy for the virtual physiological human: 2012 update.
Identifieur interne : 003966 ( PubMed/Checkpoint ); précédent : 003965; suivant : 003967A vision and strategy for the virtual physiological human: 2012 update.
Auteurs : Peter Hunter [Nouvelle-Zélande] ; Tara Chapman [Belgique] ; Peter V. Coveney [Royaume-Uni] ; Bernard De Bono [Royaume-Uni] ; Vanessa Diaz [Royaume-Uni] ; John Fenner [Royaume-Uni] ; Alejandro F. Frangi [Royaume-Uni] ; Peter Harris [Australie] ; Rod Hose [Royaume-Uni] ; Peter Kohl [Royaume-Uni] ; Pat Lawford [Royaume-Uni] ; Keith Mccormack [Royaume-Uni] ; Miriam Mendes [Royaume-Uni] ; Stig Omholt [Norvège] ; Alfio Quarteroni [Italie] ; Nour Shublaq [Royaume-Uni] ; John Sk R [Suède] ; Karl Stroetmann [Allemagne] ; Jesper Tegner [Suède] ; S Randall Thomas [France] ; Ioannis Tollis [Grèce] ; Ioannis Tsamardinos [Grèce] ; Johannes H G M. Van Beek [Pays-Bas] ; Marco Viceconti [Italie]Source :
- Interface focus [ 2042-8898 ] ; 2013.
Abstract
European funding under Framework 7 (FP7) for the virtual physiological human (VPH) project has been in place now for 5 years. The VPH Network of Excellence (NoE) has been set up to help develop common standards, open source software, freely accessible data and model repositories, and various training and dissemination activities for the project. It is also working to coordinate the many clinically targeted projects that have been funded under the FP7 calls. An initial vision for the VPH was defined by the FP6 STEP project in 2006. In 2010, we wrote an assessment of the accomplishments of the first two years of the VPH in which we considered the biomedical science, healthcare and information and communications technology challenges facing the project (Hunter et al. 2010 Phil. Trans. R. Soc. A 368, 2595-2614 (doi:10.1098/rsta.2010.0048)). We proposed that a not-for-profit professional umbrella organization, the VPH Institute, should be established as a means of sustaining the VPH vision beyond the time-frame of the NoE. Here, we update and extend this assessment and in particular address the following issues raised in response to Hunter et al.: (i) a vision for the VPH updated in the light of progress made so far, (ii) biomedical science and healthcare challenges that the VPH initiative can address while also providing innovation opportunities for the European industry, and (iii) external changes needed in regulatory policy and business models to realize the full potential that the VPH has to offer to industry, clinics and society generally.
DOI: 10.1098/rsfs.2013.0004
PubMed: 24427536
Affiliations:
- Allemagne, Australie, Belgique, France, Grèce, Italie, Norvège, Nouvelle-Zélande, Pays-Bas, Royaume-Uni, Suède
- Angleterre, Grand Londres, Île-de-France
- Londres, Orsay
- Université Paris-Sud
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National Heart and Lung Institute , Imperial College London , London , UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Computer Science , University of Oxford , Oxford , UK ; National Heart and Lung Institute , Imperial College London , London </wicri:regionArea><wicri:noRegion>London </wicri:noRegion></affiliation></author><author><name sortKey="Lawford, Pat" sort="Lawford, Pat" uniqKey="Lawford P" first="Pat" last="Lawford">Pat Lawford</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiovascular Science (Medical Physics Group), Faculty of Medicine, Dentistry and Health , University of Sheffield , Sheffield , UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Cardiovascular Science (Medical Physics Group), Faculty of Medicine, Dentistry and Health , University of Sheffield , Sheffield </wicri:regionArea><wicri:noRegion>Sheffield </wicri:noRegion></affiliation></author><author><name sortKey="Mccormack, Keith" sort="Mccormack, Keith" uniqKey="Mccormack K" first="Keith" last="Mccormack">Keith Mccormack</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiovascular Science (Medical Physics Group), Faculty of Medicine, Dentistry and Health , University of Sheffield , Sheffield , UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Cardiovascular Science (Medical Physics Group), Faculty of Medicine, Dentistry and Health , University of Sheffield , Sheffield </wicri:regionArea><wicri:noRegion>Sheffield </wicri:noRegion></affiliation></author><author><name sortKey="Mendes, Miriam" sort="Mendes, Miriam" uniqKey="Mendes M" first="Miriam" last="Mendes">Miriam Mendes</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Computational Science , University College London , London , UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Computational Science , University College London , London </wicri:regionArea><wicri:noRegion>London </wicri:noRegion></affiliation></author><author><name sortKey="Omholt, Stig" sort="Omholt, Stig" uniqKey="Omholt S" first="Stig" last="Omholt">Stig Omholt</name><affiliation wicri:level="1"><nlm:affiliation>Cardiac Exercise Research Group, Department of Circulation and Medical Imaging, NTNU Norwegian University of Science and Technology, Trondheim , Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Cardiac Exercise Research Group, Department of Circulation and Medical Imaging, NTNU Norwegian University of Science and Technology, Trondheim </wicri:regionArea><wicri:noRegion>Trondheim </wicri:noRegion></affiliation></author><author><name sortKey="Quarteroni, Alfio" sort="Quarteroni, Alfio" uniqKey="Quarteroni A" first="Alfio" last="Quarteroni">Alfio Quarteroni</name><affiliation wicri:level="1"><nlm:affiliation>Ecole Polytechnique Fédérale de Lausanne , Switzerland ; Politecnico di Milano , Milan , Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Ecole Polytechnique Fédérale de Lausanne , Switzerland ; Politecnico di Milano , Milan </wicri:regionArea><wicri:noRegion>Milan </wicri:noRegion></affiliation></author><author><name sortKey="Shublaq, Nour" sort="Shublaq, Nour" uniqKey="Shublaq N" first="Nour" last="Shublaq">Nour Shublaq</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Computational Science , University College London , London , UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Computational Science , University College London , London </wicri:regionArea><wicri:noRegion>London </wicri:noRegion></affiliation></author><author><name sortKey="Sk R, John" sort="Sk R, John" uniqKey="Sk R J" first="John" last="Sk R">John Sk R</name><affiliation wicri:level="1"><nlm:affiliation>Department of LIME , Karolinska University Hospital, Karolinska Institutet , Stockholm , Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of LIME , Karolinska University Hospital, Karolinska Institutet , Stockholm </wicri:regionArea><wicri:noRegion>Stockholm </wicri:noRegion></affiliation></author><author><name sortKey="Stroetmann, Karl" sort="Stroetmann, Karl" uniqKey="Stroetmann K" first="Karl" last="Stroetmann">Karl Stroetmann</name><affiliation wicri:level="1"><nlm:affiliation>Empirica Communication and Technology Research , Bonn , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Empirica Communication and Technology Research , Bonn </wicri:regionArea><wicri:noRegion>Bonn </wicri:noRegion><wicri:noRegion>Bonn </wicri:noRegion><wicri:noRegion>Bonn </wicri:noRegion></affiliation></author><author><name sortKey="Tegner, Jesper" sort="Tegner, Jesper" uniqKey="Tegner J" first="Jesper" last="Tegner">Jesper Tegner</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Unit for Computational Medicine, Center for Molecular Medicine , Karolinska University Hospital, Karolinska Institutet , Stockholm , Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medicine, Unit for Computational Medicine, Center for Molecular Medicine , Karolinska University Hospital, Karolinska Institutet , Stockholm </wicri:regionArea><wicri:noRegion>Stockholm </wicri:noRegion></affiliation></author><author><name sortKey="Thomas, S Randall" sort="Thomas, S Randall" uniqKey="Thomas S" first="S Randall" last="Thomas">S Randall Thomas</name><affiliation wicri:level="4"><nlm:affiliation>IR4M CNRS UMR8081, Institut Gustave-Roussy, Dept Imagerie/Echographie, Orsay , France ; Université Paris-Sud, CNRS , Orsay , France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IR4M CNRS UMR8081, Institut Gustave-Roussy, Dept Imagerie/Echographie, Orsay , France ; Université Paris-Sud, CNRS , Orsay </wicri:regionArea><wicri:noRegion>Orsay </wicri:noRegion><orgName type="university">Université Paris-Sud</orgName><placeName><settlement type="city">Orsay</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Tollis, Ioannis" sort="Tollis, Ioannis" uniqKey="Tollis I" first="Ioannis" last="Tollis">Ioannis Tollis</name><affiliation wicri:level="1"><nlm:affiliation>Computational Medicine Laboratory , Foundation for Research and Technology Hellas (FORTH) , Heraklion, Crete, Greece ; Computer Science Department , University of Crete , Heraklion, Crete, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Computational Medicine Laboratory , Foundation for Research and Technology Hellas (FORTH) , Heraklion, Crete, Greece ; Computer Science Department , University of Crete , Heraklion, Crete</wicri:regionArea><wicri:noRegion>Crete</wicri:noRegion></affiliation></author><author><name sortKey="Tsamardinos, Ioannis" sort="Tsamardinos, Ioannis" uniqKey="Tsamardinos I" first="Ioannis" last="Tsamardinos">Ioannis Tsamardinos</name><affiliation wicri:level="1"><nlm:affiliation>Bioinformatics Laboratory, Institute of Computer Science , Foundation for Research and Technology Hellas (FORTH) , Heraklion, Crete, Greece ; Computer Science Department , University of Crete , Heraklion, Crete, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Bioinformatics Laboratory, Institute of Computer Science , Foundation for Research and Technology Hellas (FORTH) , Heraklion, Crete, Greece ; Computer Science Department , University of Crete , Heraklion, Crete</wicri:regionArea><wicri:noRegion>Crete</wicri:noRegion></affiliation></author><author><name sortKey="Van Beek, Johannes H G M" sort="Van Beek, Johannes H G M" uniqKey="Van Beek J" first="Johannes H G M" last="Van Beek">Johannes H G M. Van Beek</name><affiliation wicri:level="1"><nlm:affiliation>Section Medical Genomics, Department of Clinical Genetics , VU University Medical Centre , Amsterdam , The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Section Medical Genomics, Department of Clinical Genetics , VU University Medical Centre , Amsterdam </wicri:regionArea><wicri:noRegion>Amsterdam </wicri:noRegion></affiliation></author><author><name sortKey="Viceconti, Marco" sort="Viceconti, Marco" uniqKey="Viceconti M" first="Marco" last="Viceconti">Marco Viceconti</name><affiliation wicri:level="1"><nlm:affiliation>INSIGNEO Institute for in silico medicine , University of Sheffield , Sheffield , UK ; Laboratorio di Tecnologia Medica, Istituto Ortopedico Rizzoli, Bologna , Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>INSIGNEO Institute for in silico medicine , University of Sheffield , Sheffield , UK ; Laboratorio di Tecnologia Medica, Istituto Ortopedico Rizzoli, Bologna </wicri:regionArea><wicri:noRegion>Bologna </wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:24427536</idno><idno type="pmid">24427536</idno><idno type="doi">10.1098/rsfs.2013.0004</idno><idno type="wicri:Area/PubMed/Corpus">003B40</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003B40</idno><idno type="wicri:Area/PubMed/Curation">003A10</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003A10</idno><idno type="wicri:Area/PubMed/Checkpoint">003A10</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003A10</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A vision and strategy for the virtual physiological human: 2012 update.</title><author><name sortKey="Hunter, Peter" sort="Hunter, Peter" uniqKey="Hunter P" first="Peter" last="Hunter">Peter Hunter</name><affiliation wicri:level="1"><nlm:affiliation>Department of Physiology, Anatomy and Genetics , University of Oxford , Oxford , UK ; Auckland Bioengineering Institute (ABI) , University of Auckland , New Zealand.</nlm:affiliation><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Physiology, Anatomy and Genetics , University of Oxford , Oxford , UK ; Auckland Bioengineering Institute (ABI) , University of Auckland </wicri:regionArea><wicri:noRegion>University of Auckland </wicri:noRegion></affiliation></author><author><name sortKey="Chapman, Tara" sort="Chapman, Tara" uniqKey="Chapman T" first="Tara" last="Chapman">Tara Chapman</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Anatomy, Biomechanics and Organogenesis, Faculty of Medicine , Université Libre de Bruxelles , Belgium ; Laboratory of Anthropology and Prehistory, Royal Belgian Institute of Natural Sciences, Brussels , Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Anatomy, Biomechanics and Organogenesis, Faculty of Medicine , Université Libre de Bruxelles , Belgium ; Laboratory of Anthropology and Prehistory, Royal Belgian Institute of Natural Sciences, Brussels </wicri:regionArea><wicri:noRegion>Brussels </wicri:noRegion></affiliation></author><author><name sortKey="Coveney, Peter V" sort="Coveney, Peter V" uniqKey="Coveney P" first="Peter V" last="Coveney">Peter V. Coveney</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Computational Science , University College London , London , UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Computational Science , University College London , London </wicri:regionArea><wicri:noRegion>London </wicri:noRegion></affiliation></author><author><name sortKey="De Bono, Bernard" sort="De Bono, Bernard" uniqKey="De Bono B" first="Bernard" last="De Bono">Bernard De Bono</name><affiliation wicri:level="3"><nlm:affiliation>Auckland Bioengineering Institute (ABI) , University of Auckland , New Zealand ; CHIME Institute, Archway Campus, University College London , London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Auckland Bioengineering Institute (ABI) , University of Auckland , New Zealand ; CHIME Institute, Archway Campus, University College London , London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Diaz, Vanessa" sort="Diaz, Vanessa" uniqKey="Diaz V" first="Vanessa" last="Diaz">Vanessa Diaz</name><affiliation wicri:level="1"><nlm:affiliation>Department of Mechanical Engineering , University College London , London , UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Mechanical Engineering , University College London , London </wicri:regionArea><wicri:noRegion>London </wicri:noRegion></affiliation></author><author><name sortKey="Fenner, John" sort="Fenner, John" uniqKey="Fenner J" first="John" last="Fenner">John Fenner</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiovascular Science (Medical Physics Group), Faculty of Medicine, Dentistry and Health , University of Sheffield , Sheffield , UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Cardiovascular Science (Medical Physics Group), Faculty of Medicine, Dentistry and Health , University of Sheffield , Sheffield </wicri:regionArea><wicri:noRegion>Sheffield </wicri:noRegion></affiliation></author><author><name sortKey="Frangi, Alejandro F" sort="Frangi, Alejandro F" uniqKey="Frangi A" first="Alejandro F" last="Frangi">Alejandro F. Frangi</name><affiliation wicri:level="1"><nlm:affiliation>Networking Biomedical Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Barcelona , Spain ; Center for Computational Imaging and Simulation Technologies in Biomedicine (CISTIB), Department of Mechanical Engineering, University of Sheffield, Sheffield, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Networking Biomedical Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Barcelona , Spain ; Center for Computational Imaging and Simulation Technologies in Biomedicine (CISTIB), Department of Mechanical Engineering, University of Sheffield, Sheffield</wicri:regionArea><wicri:noRegion>Sheffield</wicri:noRegion></affiliation></author><author><name sortKey="Harris, Peter" sort="Harris, Peter" uniqKey="Harris P" first="Peter" last="Harris">Peter Harris</name><affiliation wicri:level="1"><nlm:affiliation>Department of Physiology, Faculty of Medicine, Dentistry and Health Sciences , The University of Melbourne , Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Physiology, Faculty of Medicine, Dentistry and Health Sciences , The University of Melbourne </wicri:regionArea><wicri:noRegion>The University of Melbourne </wicri:noRegion></affiliation></author><author><name sortKey="Hose, Rod" sort="Hose, Rod" uniqKey="Hose R" first="Rod" last="Hose">Rod Hose</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiovascular Science (Medical Physics Group), Faculty of Medicine, Dentistry and Health , University of Sheffield , Sheffield , UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Cardiovascular Science (Medical Physics Group), Faculty of Medicine, Dentistry and Health , University of Sheffield , Sheffield </wicri:regionArea><wicri:noRegion>Sheffield </wicri:noRegion></affiliation></author><author><name sortKey="Kohl, Peter" sort="Kohl, Peter" uniqKey="Kohl P" first="Peter" last="Kohl">Peter Kohl</name><affiliation wicri:level="1"><nlm:affiliation>Department of Computer Science , University of Oxford , Oxford , UK ; National Heart and Lung Institute , Imperial College London , London , UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Computer Science , University of Oxford , Oxford , UK ; National Heart and Lung Institute , Imperial College London , London </wicri:regionArea><wicri:noRegion>London </wicri:noRegion></affiliation></author><author><name sortKey="Lawford, Pat" sort="Lawford, Pat" uniqKey="Lawford P" first="Pat" last="Lawford">Pat Lawford</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiovascular Science (Medical Physics Group), Faculty of Medicine, Dentistry and Health , University of Sheffield , Sheffield , UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Cardiovascular Science (Medical Physics Group), Faculty of Medicine, Dentistry and Health , University of Sheffield , Sheffield </wicri:regionArea><wicri:noRegion>Sheffield </wicri:noRegion></affiliation></author><author><name sortKey="Mccormack, Keith" sort="Mccormack, Keith" uniqKey="Mccormack K" first="Keith" last="Mccormack">Keith Mccormack</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiovascular Science (Medical Physics Group), Faculty of Medicine, Dentistry and Health , University of Sheffield , Sheffield , UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Cardiovascular Science (Medical Physics Group), Faculty of Medicine, Dentistry and Health , University of Sheffield , Sheffield </wicri:regionArea><wicri:noRegion>Sheffield </wicri:noRegion></affiliation></author><author><name sortKey="Mendes, Miriam" sort="Mendes, Miriam" uniqKey="Mendes M" first="Miriam" last="Mendes">Miriam Mendes</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Computational Science , University College London , London , UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Computational Science , University College London , London </wicri:regionArea><wicri:noRegion>London </wicri:noRegion></affiliation></author><author><name sortKey="Omholt, Stig" sort="Omholt, Stig" uniqKey="Omholt S" first="Stig" last="Omholt">Stig Omholt</name><affiliation wicri:level="1"><nlm:affiliation>Cardiac Exercise Research Group, Department of Circulation and Medical Imaging, NTNU Norwegian University of Science and Technology, Trondheim , Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Cardiac Exercise Research Group, Department of Circulation and Medical Imaging, NTNU Norwegian University of Science and Technology, Trondheim </wicri:regionArea><wicri:noRegion>Trondheim </wicri:noRegion></affiliation></author><author><name sortKey="Quarteroni, Alfio" sort="Quarteroni, Alfio" uniqKey="Quarteroni A" first="Alfio" last="Quarteroni">Alfio Quarteroni</name><affiliation wicri:level="1"><nlm:affiliation>Ecole Polytechnique Fédérale de Lausanne , Switzerland ; Politecnico di Milano , Milan , Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Ecole Polytechnique Fédérale de Lausanne , Switzerland ; Politecnico di Milano , Milan </wicri:regionArea><wicri:noRegion>Milan </wicri:noRegion></affiliation></author><author><name sortKey="Shublaq, Nour" sort="Shublaq, Nour" uniqKey="Shublaq N" first="Nour" last="Shublaq">Nour Shublaq</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Computational Science , University College London , London , UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Computational Science , University College London , London </wicri:regionArea><wicri:noRegion>London </wicri:noRegion></affiliation></author><author><name sortKey="Sk R, John" sort="Sk R, John" uniqKey="Sk R J" first="John" last="Sk R">John Sk R</name><affiliation wicri:level="1"><nlm:affiliation>Department of LIME , Karolinska University Hospital, Karolinska Institutet , Stockholm , Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of LIME , Karolinska University Hospital, Karolinska Institutet , Stockholm </wicri:regionArea><wicri:noRegion>Stockholm </wicri:noRegion></affiliation></author><author><name sortKey="Stroetmann, Karl" sort="Stroetmann, Karl" uniqKey="Stroetmann K" first="Karl" last="Stroetmann">Karl Stroetmann</name><affiliation wicri:level="1"><nlm:affiliation>Empirica Communication and Technology Research , Bonn , Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Empirica Communication and Technology Research , Bonn </wicri:regionArea><wicri:noRegion>Bonn </wicri:noRegion><wicri:noRegion>Bonn </wicri:noRegion><wicri:noRegion>Bonn </wicri:noRegion></affiliation></author><author><name sortKey="Tegner, Jesper" sort="Tegner, Jesper" uniqKey="Tegner J" first="Jesper" last="Tegner">Jesper Tegner</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Unit for Computational Medicine, Center for Molecular Medicine , Karolinska University Hospital, Karolinska Institutet , Stockholm , Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medicine, Unit for Computational Medicine, Center for Molecular Medicine , Karolinska University Hospital, Karolinska Institutet , Stockholm </wicri:regionArea><wicri:noRegion>Stockholm </wicri:noRegion></affiliation></author><author><name sortKey="Thomas, S Randall" sort="Thomas, S Randall" uniqKey="Thomas S" first="S Randall" last="Thomas">S Randall Thomas</name><affiliation wicri:level="4"><nlm:affiliation>IR4M CNRS UMR8081, Institut Gustave-Roussy, Dept Imagerie/Echographie, Orsay , France ; Université Paris-Sud, CNRS , Orsay , France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IR4M CNRS UMR8081, Institut Gustave-Roussy, Dept Imagerie/Echographie, Orsay , France ; Université Paris-Sud, CNRS , Orsay </wicri:regionArea><wicri:noRegion>Orsay </wicri:noRegion><orgName type="university">Université Paris-Sud</orgName><placeName><settlement type="city">Orsay</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Tollis, Ioannis" sort="Tollis, Ioannis" uniqKey="Tollis I" first="Ioannis" last="Tollis">Ioannis Tollis</name><affiliation wicri:level="1"><nlm:affiliation>Computational Medicine Laboratory , Foundation for Research and Technology Hellas (FORTH) , Heraklion, Crete, Greece ; Computer Science Department , University of Crete , Heraklion, Crete, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Computational Medicine Laboratory , Foundation for Research and Technology Hellas (FORTH) , Heraklion, Crete, Greece ; Computer Science Department , University of Crete , Heraklion, Crete</wicri:regionArea><wicri:noRegion>Crete</wicri:noRegion></affiliation></author><author><name sortKey="Tsamardinos, Ioannis" sort="Tsamardinos, Ioannis" uniqKey="Tsamardinos I" first="Ioannis" last="Tsamardinos">Ioannis Tsamardinos</name><affiliation wicri:level="1"><nlm:affiliation>Bioinformatics Laboratory, Institute of Computer Science , Foundation for Research and Technology Hellas (FORTH) , Heraklion, Crete, Greece ; Computer Science Department , University of Crete , Heraklion, Crete, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Bioinformatics Laboratory, Institute of Computer Science , Foundation for Research and Technology Hellas (FORTH) , Heraklion, Crete, Greece ; Computer Science Department , University of Crete , Heraklion, Crete</wicri:regionArea><wicri:noRegion>Crete</wicri:noRegion></affiliation></author><author><name sortKey="Van Beek, Johannes H G M" sort="Van Beek, Johannes H G M" uniqKey="Van Beek J" first="Johannes H G M" last="Van Beek">Johannes H G M. Van Beek</name><affiliation wicri:level="1"><nlm:affiliation>Section Medical Genomics, Department of Clinical Genetics , VU University Medical Centre , Amsterdam , The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Section Medical Genomics, Department of Clinical Genetics , VU University Medical Centre , Amsterdam </wicri:regionArea><wicri:noRegion>Amsterdam </wicri:noRegion></affiliation></author><author><name sortKey="Viceconti, Marco" sort="Viceconti, Marco" uniqKey="Viceconti M" first="Marco" last="Viceconti">Marco Viceconti</name><affiliation wicri:level="1"><nlm:affiliation>INSIGNEO Institute for in silico medicine , University of Sheffield , Sheffield , UK ; Laboratorio di Tecnologia Medica, Istituto Ortopedico Rizzoli, Bologna , Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>INSIGNEO Institute for in silico medicine , University of Sheffield , Sheffield , UK ; Laboratorio di Tecnologia Medica, Istituto Ortopedico Rizzoli, Bologna </wicri:regionArea><wicri:noRegion>Bologna </wicri:noRegion></affiliation></author></analytic><series><title level="j">Interface focus</title><idno type="ISSN">2042-8898</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">European funding under Framework 7 (FP7) for the virtual physiological human (VPH) project has been in place now for 5 years. The VPH Network of Excellence (NoE) has been set up to help develop common standards, open source software, freely accessible data and model repositories, and various training and dissemination activities for the project. It is also working to coordinate the many clinically targeted projects that have been funded under the FP7 calls. An initial vision for the VPH was defined by the FP6 STEP project in 2006. In 2010, we wrote an assessment of the accomplishments of the first two years of the VPH in which we considered the biomedical science, healthcare and information and communications technology challenges facing the project (Hunter et al. 2010 Phil. Trans. R. Soc. A 368, 2595-2614 (doi:10.1098/rsta.2010.0048)). We proposed that a not-for-profit professional umbrella organization, the VPH Institute, should be established as a means of sustaining the VPH vision beyond the time-frame of the NoE. Here, we update and extend this assessment and in particular address the following issues raised in response to Hunter et al.: (i) a vision for the VPH updated in the light of progress made so far, (ii) biomedical science and healthcare challenges that the VPH initiative can address while also providing innovation opportunities for the European industry, and (iii) external changes needed in regulatory policy and business models to realize the full potential that the VPH has to offer to industry, clinics and society generally.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">24427536</PMID><DateCreated><Year>2014</Year><Month>01</Month><Day>15</Day></DateCreated><DateCompleted><Year>2014</Year><Month>01</Month><Day>15</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">2042-8898</ISSN><JournalIssue CitedMedium="Print"><Volume>3</Volume><Issue>2</Issue><PubDate><Year>2013</Year><Month>Apr</Month><Day>06</Day></PubDate></JournalIssue><Title>Interface focus</Title><ISOAbbreviation>Interface Focus</ISOAbbreviation></Journal><ArticleTitle>A vision and strategy for the virtual physiological human: 2012 update.</ArticleTitle><Pagination><MedlinePgn>20130004</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1098/rsfs.2013.0004</ELocationID><Abstract><AbstractText>European funding under Framework 7 (FP7) for the virtual physiological human (VPH) project has been in place now for 5 years. The VPH Network of Excellence (NoE) has been set up to help develop common standards, open source software, freely accessible data and model repositories, and various training and dissemination activities for the project. It is also working to coordinate the many clinically targeted projects that have been funded under the FP7 calls. An initial vision for the VPH was defined by the FP6 STEP project in 2006. In 2010, we wrote an assessment of the accomplishments of the first two years of the VPH in which we considered the biomedical science, healthcare and information and communications technology challenges facing the project (Hunter et al. 2010 Phil. Trans. R. Soc. A 368, 2595-2614 (doi:10.1098/rsta.2010.0048)). We proposed that a not-for-profit professional umbrella organization, the VPH Institute, should be established as a means of sustaining the VPH vision beyond the time-frame of the NoE. Here, we update and extend this assessment and in particular address the following issues raised in response to Hunter et al.: (i) a vision for the VPH updated in the light of progress made so far, (ii) biomedical science and healthcare challenges that the VPH initiative can address while also providing innovation opportunities for the European industry, and (iii) external changes needed in regulatory policy and business models to realize the full potential that the VPH has to offer to industry, clinics and society generally.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hunter</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Physiology, Anatomy and Genetics , University of Oxford , Oxford , UK ; Auckland Bioengineering Institute (ABI) , University of Auckland , New Zealand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chapman</LastName><ForeName>Tara</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Laboratory of Anatomy, Biomechanics and Organogenesis, Faculty of Medicine , Université Libre de Bruxelles , Belgium ; Laboratory of Anthropology and Prehistory, Royal Belgian Institute of Natural Sciences, Brussels , Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Coveney</LastName><ForeName>Peter V</ForeName><Initials>PV</Initials><AffiliationInfo><Affiliation>Centre for Computational Science , University College London , London , UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Bono</LastName><ForeName>Bernard</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Auckland Bioengineering Institute (ABI) , University of Auckland , New Zealand ; CHIME Institute, Archway Campus, University College London , London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Diaz</LastName><ForeName>Vanessa</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Mechanical Engineering , University College London , London , UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fenner</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Cardiovascular Science (Medical Physics Group), Faculty of Medicine, Dentistry and Health , University of Sheffield , Sheffield , UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Frangi</LastName><ForeName>Alejandro F</ForeName><Initials>AF</Initials><AffiliationInfo><Affiliation>Networking Biomedical Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Barcelona , Spain ; Center for Computational Imaging and Simulation Technologies in Biomedicine (CISTIB), Department of Mechanical Engineering, University of Sheffield, Sheffield, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Harris</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Physiology, Faculty of Medicine, Dentistry and Health Sciences , The University of Melbourne , Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hose</LastName><ForeName>Rod</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Cardiovascular Science (Medical Physics Group), Faculty of Medicine, Dentistry and Health , University of Sheffield , Sheffield , UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kohl</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Computer Science , University of Oxford , Oxford , UK ; National Heart and Lung Institute , Imperial College London , London , UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lawford</LastName><ForeName>Pat</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Cardiovascular Science (Medical Physics Group), Faculty of Medicine, Dentistry and Health , University of Sheffield , Sheffield , UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McCormack</LastName><ForeName>Keith</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Cardiovascular Science (Medical Physics Group), Faculty of Medicine, Dentistry and Health , University of Sheffield , Sheffield , UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mendes</LastName><ForeName>Miriam</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Centre for Computational Science , University College London , London , UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Omholt</LastName><ForeName>Stig</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Cardiac Exercise Research Group, Department of Circulation and Medical Imaging, NTNU Norwegian University of Science and Technology, Trondheim , Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Quarteroni</LastName><ForeName>Alfio</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Ecole Polytechnique Fédérale de Lausanne , Switzerland ; Politecnico di Milano , Milan , Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shublaq</LastName><ForeName>Nour</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Centre for Computational Science , University College London , London , UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Skår</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of LIME , Karolinska University Hospital, Karolinska Institutet , Stockholm , Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stroetmann</LastName><ForeName>Karl</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Empirica Communication and Technology Research , Bonn , Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tegner</LastName><ForeName>Jesper</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Medicine, Unit for Computational Medicine, Center for Molecular Medicine , Karolinska University Hospital, Karolinska Institutet , Stockholm , Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thomas</LastName><ForeName>S Randall</ForeName><Initials>SR</Initials><AffiliationInfo><Affiliation>IR4M CNRS UMR8081, Institut Gustave-Roussy, Dept Imagerie/Echographie, Orsay , France ; Université Paris-Sud, CNRS , Orsay , France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tollis</LastName><ForeName>Ioannis</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Computational Medicine Laboratory , Foundation for Research and Technology Hellas (FORTH) , Heraklion, Crete, Greece ; Computer Science Department , University of Crete , Heraklion, Crete, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tsamardinos</LastName><ForeName>Ioannis</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Bioinformatics Laboratory, Institute of Computer Science , Foundation for Research and Technology Hellas (FORTH) , Heraklion, Crete, Greece ; Computer Science Department , University of Crete , Heraklion, Crete, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Beek</LastName><ForeName>Johannes H G M</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Section Medical Genomics, Department of Clinical Genetics , VU University Medical Centre , Amsterdam , The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Viceconti</LastName><ForeName>Marco</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>INSIGNEO Institute for in silico medicine , University of Sheffield , Sheffield , UK ; Laboratorio di Tecnologia Medica, Istituto Ortopedico Rizzoli, Bologna , Italy.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>FS/12/17/29532</GrantID><Agency>British Heart Foundation</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>MR/K006584/1</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>PG/09/031/27221</GrantID><Agency>British Heart Foundation</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Interface Focus</MedlineTA><NlmUniqueID>101531990</NlmUniqueID><ISSNLinking>2042-8898</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Philos Trans A Math Phys Eng Sci. 2008 Sep 13;366(1878):3017-43</RefSource><PMID Version="1">18579471</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Philos Trans A Math Phys Eng Sci. 2010 Jun 13;368(1920):2591-4</RefSource><PMID Version="1">20439263</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Bioinformatics. 2008 Sep 15;24(18):2122-3</RefSource><PMID Version="1">18658182</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Pharmacol Ther. 2010 Jul;88(1):25-33</RefSource><PMID Version="1">20531468</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Philos Trans A Math Phys Eng Sci. 2010 Jun 13;368(1920):2595-614</RefSource><PMID 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PubStatus="entrez"><Year>2014</Year><Month>1</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>1</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>1</Month><Day>16</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24427536</ArticleId><ArticleId IdType="doi">10.1098/rsfs.2013.0004</ArticleId><ArticleId IdType="pii">rsfs20130004</ArticleId><ArticleId IdType="pmc">PMC3638492</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>France</li><li>Grèce</li><li>Italie</li><li>Norvège</li><li>Nouvelle-Zélande</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suède</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Île-de-France</li></region><settlement><li>Londres</li><li>Orsay</li></settlement><orgName><li>Université Paris-Sud</li></orgName></list><tree><country name="Nouvelle-Zélande"><noRegion><name sortKey="Hunter, Peter" sort="Hunter, Peter" uniqKey="Hunter P" first="Peter" last="Hunter">Peter Hunter</name></noRegion></country><country name="Belgique"><noRegion><name sortKey="Chapman, Tara" sort="Chapman, Tara" uniqKey="Chapman T" first="Tara" last="Chapman">Tara Chapman</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Coveney, Peter V" sort="Coveney, Peter V" uniqKey="Coveney P" first="Peter V" last="Coveney">Peter V. Coveney</name></noRegion><name sortKey="De Bono, Bernard" sort="De Bono, Bernard" uniqKey="De Bono B" first="Bernard" last="De Bono">Bernard De Bono</name><name sortKey="Diaz, Vanessa" sort="Diaz, Vanessa" uniqKey="Diaz V" first="Vanessa" last="Diaz">Vanessa Diaz</name><name sortKey="Fenner, John" sort="Fenner, John" uniqKey="Fenner J" first="John" last="Fenner">John Fenner</name><name sortKey="Frangi, Alejandro F" sort="Frangi, Alejandro F" uniqKey="Frangi A" first="Alejandro F" last="Frangi">Alejandro F. Frangi</name><name sortKey="Hose, Rod" sort="Hose, Rod" uniqKey="Hose R" first="Rod" last="Hose">Rod Hose</name><name sortKey="Kohl, Peter" sort="Kohl, Peter" uniqKey="Kohl P" first="Peter" last="Kohl">Peter Kohl</name><name sortKey="Lawford, Pat" sort="Lawford, Pat" uniqKey="Lawford P" first="Pat" last="Lawford">Pat Lawford</name><name sortKey="Mccormack, Keith" sort="Mccormack, Keith" uniqKey="Mccormack K" first="Keith" last="Mccormack">Keith Mccormack</name><name sortKey="Mendes, Miriam" sort="Mendes, Miriam" uniqKey="Mendes M" first="Miriam" last="Mendes">Miriam Mendes</name><name sortKey="Shublaq, Nour" sort="Shublaq, Nour" uniqKey="Shublaq N" first="Nour" last="Shublaq">Nour Shublaq</name></country><country name="Australie"><noRegion><name sortKey="Harris, Peter" sort="Harris, Peter" uniqKey="Harris P" first="Peter" last="Harris">Peter Harris</name></noRegion></country><country name="Norvège"><noRegion><name sortKey="Omholt, Stig" sort="Omholt, Stig" uniqKey="Omholt S" first="Stig" last="Omholt">Stig Omholt</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Quarteroni, Alfio" sort="Quarteroni, Alfio" uniqKey="Quarteroni A" first="Alfio" last="Quarteroni">Alfio Quarteroni</name></noRegion><name sortKey="Viceconti, Marco" sort="Viceconti, Marco" uniqKey="Viceconti M" first="Marco" last="Viceconti">Marco Viceconti</name></country><country name="Suède"><noRegion><name sortKey="Sk R, John" sort="Sk R, John" uniqKey="Sk R J" first="John" last="Sk R">John Sk R</name></noRegion><name sortKey="Tegner, Jesper" sort="Tegner, Jesper" uniqKey="Tegner J" first="Jesper" last="Tegner">Jesper Tegner</name></country><country name="Allemagne"><noRegion><name sortKey="Stroetmann, Karl" sort="Stroetmann, Karl" uniqKey="Stroetmann K" first="Karl" last="Stroetmann">Karl Stroetmann</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Thomas, S Randall" sort="Thomas, S Randall" uniqKey="Thomas S" first="S Randall" last="Thomas">S Randall Thomas</name></region></country><country name="Grèce"><noRegion><name sortKey="Tollis, Ioannis" sort="Tollis, Ioannis" uniqKey="Tollis I" first="Ioannis" last="Tollis">Ioannis Tollis</name></noRegion><name sortKey="Tsamardinos, Ioannis" sort="Tsamardinos, Ioannis" uniqKey="Tsamardinos I" first="Ioannis" last="Tsamardinos">Ioannis Tsamardinos</name></country><country name="Pays-Bas"><noRegion><name sortKey="Van Beek, Johannes H G M" sort="Van Beek, Johannes H G M" uniqKey="Van Beek J" first="Johannes H G M" last="Van Beek">Johannes H G M. Van Beek</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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