Genetic predictors of circulating 25-hydroxyvitamin d and risk of colorectal cancer.
Identifieur interne : 003932 ( PubMed/Checkpoint ); précédent : 003931; suivant : 003933Genetic predictors of circulating 25-hydroxyvitamin d and risk of colorectal cancer.
Auteurs : Linda T. Hiraki [Australie] ; Conghui Qu ; Carolyn M. Hutter ; John A. Baron ; Sonja I. Berndt ; Stéphane Bézieau ; Hermann Brenner ; Bette J. Caan ; Graham Casey ; Jenny Chang-Claude ; Stephen J. Chanock ; David V. Conti ; David Duggan ; Charles S. Fuchs ; Steven Gallinger ; Edward L. Giovannucci ; Tabitha A. Harrison ; Richard B. Hayes ; Aditi Hazra ; Brian Henderson ; Michael Hoffmeister ; John L. Hopper ; Thomas J. Hudson ; Mark A. Jenkins ; Sébastien Küry ; Loic Le Marchand ; Mathieu Lemire ; Jing Ma ; Joann E. Manson ; Hongmei Nan ; Polly A. Newcomb ; Kimmie Ng ; John D. Potter ; Robert E. Schoen ; Fredrick R. Schumacher ; Daniela Seminara ; Martha L. Slattery ; Jean Wactawski-Wende ; Emily White ; Kana Wu ; Brent W. Zanke ; Peter Kraft ; Ulrike Peters ; Andrew T. ChanSource :
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [ 1538-7755 ] ; 2013.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Facteurs de risque, Femelle, Génotype, Humains, Polymorphisme de nucléotide simple, Prédisposition génétique à une maladie, Régime alimentaire, Tumeurs colorectales (génétique), Tumeurs colorectales (sang), Vitamine D (analogues et dérivés), Vitamine D (génétique), Vitamine D (sang).
- MESH :
- analogues et dérivés : Vitamine D.
- génétique : Tumeurs colorectales, Vitamine D.
- sang : Tumeurs colorectales, Vitamine D.
- Adulte d'âge moyen, Facteurs de risque, Femelle, Génotype, Humains, Polymorphisme de nucléotide simple, Prédisposition génétique à une maladie, Régime alimentaire.
English descriptors
- KwdEn :
- MESH :
- chemical , analogs & derivatives : Vitamin D.
- blood : Colorectal Neoplasms, Vitamin D.
- genetics : Colorectal Neoplasms, Vitamin D.
- Diet, Female, Genetic Predisposition to Disease, Genotype, Humans, Middle Aged, Polymorphism, Single Nucleotide, Risk Factors.
Abstract
Experimental evidence has demonstrated an antineoplastic role for vitamin D in the colon, and higher circulating 25-hydroxyvitamin D [25(OH)D] levels are consistently associated with a lower risk of colorectal cancer. Genome-wide association studies have identified loci associated with levels of circulating 25(OH)D. The identified single-nucleotide polymorphisms (SNPs) from four gene regions collectively explain approximately 5% of the variance in circulating 25(OH)D.
DOI: 10.1158/1055-9965.EPI-13-0209
PubMed: 23983240
Affiliations:
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pubmed:23983240Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genetic predictors of circulating 25-hydroxyvitamin d and risk of colorectal cancer.</title><author><name sortKey="Hiraki, Linda T" sort="Hiraki, Linda T" uniqKey="Hiraki L" first="Linda T" last="Hiraki">Linda T. Hiraki</name><affiliation wicri:level="1"><nlm:affiliation>Authors' Affiliations: Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Departments of Nutrition, and Biostatistics, Harvard School of Public Health; Department of Medicine, and Channing Division of Network Medicine, Brigham and Women's Hospital; Division of Gastroenterology, Massachusetts General Hospital; Department of Medicine, Harvard Medical School; Gastrointestinal Malignancy Program, and Medical-Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; Public Health Sciences Division, Fred Hutchinson Cancer Research Center; Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington; Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, North Carolina; Divisions of Cancer Epidemiology and Genetics, and Cancer Control and Population Sciences, National Cancer Institute, NIH, Bethesda; University of Maryland, School of Medicine, Baltimore, Maryland; Service de Génétique Médicale, CHU Nantes, Nantes, France; Divisions of Clinical Epidemiology and Aging Research and Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany; Division of Research, Kaiser Permanente Medical Care Program, Oakland; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; Translational Genomics Research Institute, Phoenix, Arizona; Department of Surgery, Toronto General Hospital; Ontario Institute for Cancer Research; Departments of Medical Biophysics and Molecular Genetics, University of Toronto, Toronto; Faculty of Medicine, The University of Ottawa, Ottawa, Ontario, Canada; Department of Environmental Medicine, Division of Epidemiology, New York University School of Medicine, New York; Department of Social and Preventive Medicine, University of Buffalo, Buffalo, New York; Melborne School of Population Health, The University of Melbourne, Melbourne, Victoria, Australia; Epidemiology Pro</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Authors' Affiliations: Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Departments of Nutrition, and Biostatistics, Harvard School of Public Health; Department of Medicine, and Channing Division of Network Medicine, Brigham and Women's Hospital; Division of Gastroenterology, Massachusetts General Hospital; Department of Medicine, Harvard Medical School; Gastrointestinal Malignancy Program, and Medical-Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; Public Health Sciences Division, Fred Hutchinson Cancer Research Center; Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington; Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, North Carolina; Divisions of Cancer Epidemiology and Genetics, and Cancer Control and Population Sciences, National Cancer Institute, NIH, Bethesda; University of Maryland, School of Medicine, Baltimore, Maryland; Service de Génétique Médicale, CHU Nantes, Nantes, France; Divisions of Clinical Epidemiology and Aging Research and Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany; Division of Research, Kaiser Permanente Medical Care Program, Oakland; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; Translational Genomics Research Institute, Phoenix, Arizona; Department of Surgery, Toronto General Hospital; Ontario Institute for Cancer Research; Departments of Medical Biophysics and Molecular Genetics, University of Toronto, Toronto; Faculty of Medicine, The University of Ottawa, Ottawa, Ontario, Canada; Department of Environmental Medicine, Division of Epidemiology, New York University School of Medicine, New York; Department of Social and Preventive Medicine, University of Buffalo, Buffalo, New York; Melborne School of Population Health, The University of Melbourne, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Qu, Conghui" sort="Qu, Conghui" uniqKey="Qu C" first="Conghui" last="Qu">Conghui Qu</name></author><author><name sortKey="Hutter, Carolyn M" sort="Hutter, Carolyn M" uniqKey="Hutter C" first="Carolyn M" last="Hutter">Carolyn M. Hutter</name></author><author><name sortKey="Baron, John A" sort="Baron, John A" uniqKey="Baron J" first="John A" last="Baron">John A. Baron</name></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I" last="Berndt">Sonja I. Berndt</name></author><author><name sortKey="Bezieau, Stephane" sort="Bezieau, Stephane" uniqKey="Bezieau S" first="Stéphane" last="Bézieau">Stéphane Bézieau</name></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name></author><author><name sortKey="Caan, Bette J" sort="Caan, Bette J" uniqKey="Caan B" first="Bette J" last="Caan">Bette J. 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Slattery</name></author><author><name sortKey="Wactawski Wende, Jean" sort="Wactawski Wende, Jean" uniqKey="Wactawski Wende J" first="Jean" last="Wactawski-Wende">Jean Wactawski-Wende</name></author><author><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name></author><author><name sortKey="Wu, Kana" sort="Wu, Kana" uniqKey="Wu K" first="Kana" last="Wu">Kana Wu</name></author><author><name sortKey="Zanke, Brent W" sort="Zanke, Brent W" uniqKey="Zanke B" first="Brent W" last="Zanke">Brent W. Zanke</name></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name></author><author><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T" last="Chan">Andrew T. Chan</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23983240</idno><idno type="pmid">23983240</idno><idno type="doi">10.1158/1055-9965.EPI-13-0209</idno><idno type="wicri:Area/PubMed/Corpus">003A97</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003A97</idno><idno type="wicri:Area/PubMed/Curation">003967</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003967</idno><idno type="wicri:Area/PubMed/Checkpoint">003967</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003967</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Genetic predictors of circulating 25-hydroxyvitamin d and risk of colorectal cancer.</title><author><name sortKey="Hiraki, Linda T" sort="Hiraki, Linda T" uniqKey="Hiraki L" first="Linda T" last="Hiraki">Linda T. Hiraki</name><affiliation wicri:level="1"><nlm:affiliation>Authors' Affiliations: Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Departments of Nutrition, and Biostatistics, Harvard School of Public Health; Department of Medicine, and Channing Division of Network Medicine, Brigham and Women's Hospital; Division of Gastroenterology, Massachusetts General Hospital; Department of Medicine, Harvard Medical School; Gastrointestinal Malignancy Program, and Medical-Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; Public Health Sciences Division, Fred Hutchinson Cancer Research Center; Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington; Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, North Carolina; Divisions of Cancer Epidemiology and Genetics, and Cancer Control and Population Sciences, National Cancer Institute, NIH, Bethesda; University of Maryland, School of Medicine, Baltimore, Maryland; Service de Génétique Médicale, CHU Nantes, Nantes, France; Divisions of Clinical Epidemiology and Aging Research and Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany; Division of Research, Kaiser Permanente Medical Care Program, Oakland; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; Translational Genomics Research Institute, Phoenix, Arizona; Department of Surgery, Toronto General Hospital; Ontario Institute for Cancer Research; Departments of Medical Biophysics and Molecular Genetics, University of Toronto, Toronto; Faculty of Medicine, The University of Ottawa, Ottawa, Ontario, Canada; Department of Environmental Medicine, Division of Epidemiology, New York University School of Medicine, New York; Department of Social and Preventive Medicine, University of Buffalo, Buffalo, New York; Melborne School of Population Health, The University of Melbourne, Melbourne, Victoria, Australia; Epidemiology Pro</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Authors' Affiliations: Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Departments of Nutrition, and Biostatistics, Harvard School of Public Health; Department of Medicine, and Channing Division of Network Medicine, Brigham and Women's Hospital; Division of Gastroenterology, Massachusetts General Hospital; Department of Medicine, Harvard Medical School; Gastrointestinal Malignancy Program, and Medical-Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; Public Health Sciences Division, Fred Hutchinson Cancer Research Center; Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington; Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, North Carolina; Divisions of Cancer Epidemiology and Genetics, and Cancer Control and Population Sciences, National Cancer Institute, NIH, Bethesda; University of Maryland, School of Medicine, Baltimore, Maryland; Service de Génétique Médicale, CHU Nantes, Nantes, France; Divisions of Clinical Epidemiology and Aging Research and Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany; Division of Research, Kaiser Permanente Medical Care Program, Oakland; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; Translational Genomics Research Institute, Phoenix, Arizona; Department of Surgery, Toronto General Hospital; Ontario Institute for Cancer Research; Departments of Medical Biophysics and Molecular Genetics, University of Toronto, Toronto; Faculty of Medicine, The University of Ottawa, Ottawa, Ontario, Canada; Department of Environmental Medicine, Division of Epidemiology, New York University School of Medicine, New York; Department of Social and Preventive Medicine, University of Buffalo, Buffalo, New York; Melborne School of Population Health, The University of Melbourne, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Qu, Conghui" sort="Qu, Conghui" uniqKey="Qu C" first="Conghui" last="Qu">Conghui Qu</name></author><author><name sortKey="Hutter, Carolyn M" sort="Hutter, Carolyn M" uniqKey="Hutter C" first="Carolyn M" last="Hutter">Carolyn M. Hutter</name></author><author><name sortKey="Baron, John A" sort="Baron, John A" uniqKey="Baron J" first="John A" last="Baron">John A. Baron</name></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I" last="Berndt">Sonja I. Berndt</name></author><author><name sortKey="Bezieau, Stephane" sort="Bezieau, Stephane" uniqKey="Bezieau S" first="Stéphane" last="Bézieau">Stéphane Bézieau</name></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name></author><author><name sortKey="Caan, Bette J" sort="Caan, Bette J" uniqKey="Caan B" first="Bette J" last="Caan">Bette J. Caan</name></author><author><name sortKey="Casey, Graham" sort="Casey, Graham" uniqKey="Casey G" first="Graham" last="Casey">Graham Casey</name></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J" last="Chanock">Stephen J. Chanock</name></author><author><name sortKey="Conti, David V" sort="Conti, David V" uniqKey="Conti D" first="David V" last="Conti">David V. Conti</name></author><author><name sortKey="Duggan, David" sort="Duggan, David" uniqKey="Duggan D" first="David" last="Duggan">David Duggan</name></author><author><name sortKey="Fuchs, Charles S" sort="Fuchs, Charles S" uniqKey="Fuchs C" first="Charles S" last="Fuchs">Charles S. Fuchs</name></author><author><name sortKey="Gallinger, Steven" sort="Gallinger, Steven" uniqKey="Gallinger S" first="Steven" last="Gallinger">Steven Gallinger</name></author><author><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L" last="Giovannucci">Edward L. Giovannucci</name></author><author><name sortKey="Harrison, Tabitha A" sort="Harrison, Tabitha A" uniqKey="Harrison T" first="Tabitha A" last="Harrison">Tabitha A. Harrison</name></author><author><name sortKey="Hayes, Richard B" sort="Hayes, Richard B" uniqKey="Hayes R" first="Richard B" last="Hayes">Richard B. Hayes</name></author><author><name sortKey="Hazra, Aditi" sort="Hazra, Aditi" uniqKey="Hazra A" first="Aditi" last="Hazra">Aditi Hazra</name></author><author><name sortKey="Henderson, Brian" sort="Henderson, Brian" uniqKey="Henderson B" first="Brian" last="Henderson">Brian Henderson</name></author><author><name sortKey="Hoffmeister, Michael" sort="Hoffmeister, Michael" uniqKey="Hoffmeister M" first="Michael" last="Hoffmeister">Michael Hoffmeister</name></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name></author><author><name sortKey="Hudson, Thomas J" sort="Hudson, Thomas J" uniqKey="Hudson T" first="Thomas J" last="Hudson">Thomas J. Hudson</name></author><author><name sortKey="Jenkins, Mark A" sort="Jenkins, Mark A" uniqKey="Jenkins M" first="Mark A" last="Jenkins">Mark A. Jenkins</name></author><author><name sortKey="Kury, Sebastien" sort="Kury, Sebastien" uniqKey="Kury S" first="Sébastien" last="Küry">Sébastien Küry</name></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name></author><author><name sortKey="Lemire, Mathieu" sort="Lemire, Mathieu" uniqKey="Lemire M" first="Mathieu" last="Lemire">Mathieu Lemire</name></author><author><name sortKey="Ma, Jing" sort="Ma, Jing" uniqKey="Ma J" first="Jing" last="Ma">Jing Ma</name></author><author><name sortKey="Manson, Joann E" sort="Manson, Joann E" uniqKey="Manson J" first="Joann E" last="Manson">Joann E. Manson</name></author><author><name sortKey="Nan, Hongmei" sort="Nan, Hongmei" uniqKey="Nan H" first="Hongmei" last="Nan">Hongmei Nan</name></author><author><name sortKey="Newcomb, Polly A" sort="Newcomb, Polly A" uniqKey="Newcomb P" first="Polly A" last="Newcomb">Polly A. Newcomb</name></author><author><name sortKey="Ng, Kimmie" sort="Ng, Kimmie" uniqKey="Ng K" first="Kimmie" last="Ng">Kimmie Ng</name></author><author><name sortKey="Potter, John D" sort="Potter, John D" uniqKey="Potter J" first="John D" last="Potter">John D. Potter</name></author><author><name sortKey="Schoen, Robert E" sort="Schoen, Robert E" uniqKey="Schoen R" first="Robert E" last="Schoen">Robert E. Schoen</name></author><author><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R" last="Schumacher">Fredrick R. Schumacher</name></author><author><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name></author><author><name sortKey="Slattery, Martha L" sort="Slattery, Martha L" uniqKey="Slattery M" first="Martha L" last="Slattery">Martha L. Slattery</name></author><author><name sortKey="Wactawski Wende, Jean" sort="Wactawski Wende, Jean" uniqKey="Wactawski Wende J" first="Jean" last="Wactawski-Wende">Jean Wactawski-Wende</name></author><author><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name></author><author><name sortKey="Wu, Kana" sort="Wu, Kana" uniqKey="Wu K" first="Kana" last="Wu">Kana Wu</name></author><author><name sortKey="Zanke, Brent W" sort="Zanke, Brent W" uniqKey="Zanke B" first="Brent W" last="Zanke">Brent W. Zanke</name></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name></author><author><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T" last="Chan">Andrew T. Chan</name></author></analytic><series><title level="j">Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</title><idno type="eISSN">1538-7755</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Colorectal Neoplasms (blood)</term><term>Colorectal Neoplasms (genetics)</term><term>Diet</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Genotype</term><term>Humans</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term><term>Risk Factors</term><term>Vitamin D (analogs & derivatives)</term><term>Vitamin D (blood)</term><term>Vitamin D (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Facteurs de risque</term><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Polymorphisme de nucléotide simple</term><term>Prédisposition génétique à une maladie</term><term>Régime alimentaire</term><term>Tumeurs colorectales (génétique)</term><term>Tumeurs colorectales (sang)</term><term>Vitamine D (analogues et dérivés)</term><term>Vitamine D (génétique)</term><term>Vitamine D (sang)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Vitamin D</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Vitamine D</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Colorectal Neoplasms</term><term>Vitamin D</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Colorectal Neoplasms</term><term>Vitamin D</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Tumeurs colorectales</term><term>Vitamine D</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Tumeurs colorectales</term><term>Vitamine D</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Diet</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Genotype</term><term>Humans</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Facteurs de risque</term><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Polymorphisme de nucléotide simple</term><term>Prédisposition génétique à une maladie</term><term>Régime alimentaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Experimental evidence has demonstrated an antineoplastic role for vitamin D in the colon, and higher circulating 25-hydroxyvitamin D [25(OH)D] levels are consistently associated with a lower risk of colorectal cancer. Genome-wide association studies have identified loci associated with levels of circulating 25(OH)D. The identified single-nucleotide polymorphisms (SNPs) from four gene regions collectively explain approximately 5% of the variance in circulating 25(OH)D.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23983240</PMID><DateCreated><Year>2013</Year><Month>11</Month><Day>05</Day></DateCreated><DateCompleted><Year>2014</Year><Month>08</Month><Day>22</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1538-7755</ISSN><JournalIssue CitedMedium="Internet"><Volume>22</Volume><Issue>11</Issue><PubDate><Year>2013</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</Title><ISOAbbreviation>Cancer Epidemiol. Biomarkers Prev.</ISOAbbreviation></Journal><ArticleTitle>Genetic predictors of circulating 25-hydroxyvitamin d and risk of colorectal cancer.</ArticleTitle><Pagination><MedlinePgn>2037-46</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1158/1055-9965.EPI-13-0209</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Experimental evidence has demonstrated an antineoplastic role for vitamin D in the colon, and higher circulating 25-hydroxyvitamin D [25(OH)D] levels are consistently associated with a lower risk of colorectal cancer. Genome-wide association studies have identified loci associated with levels of circulating 25(OH)D. The identified single-nucleotide polymorphisms (SNPs) from four gene regions collectively explain approximately 5% of the variance in circulating 25(OH)D.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We investigated whether five polymorphisms in GC, CYP2R1, CYP24A1, and DHCR7/NADSYN1, genes previously shown to be associated with circulating 25(OH)D levels, were associated with colorectal cancer risk in 10,061 cases and 12,768 controls drawn from 13 studies included in the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO) and Colon Cancer Family Registry (CCFR). We conducted a meta-analysis of crude and multivariate-adjusted logistic regression models to calculate odds ratios and associated confidence intervals for SNPs individually, SNPs simultaneously, and for a vitamin D additive genetic risk score (GRS).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">We did not observe a statistically significant association between the 25(OH)D-associated SNPs and colorectal cancer marginally, conditionally, or as a GRS, or for colon or rectal cancer separately.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our findings do not support an association between SNPs associated with circulating 25(OH)D and risk of colorectal cancer. Additional work is warranted to investigate the complex relationship between 25(OH)D and colorectal cancer risk.</AbstractText><AbstractText Label="IMPACT" NlmCategory="CONCLUSIONS">There was no association observed between genetic markers of circulating 25(OH)D and colorectal cancer. These genetic markers account for a small proportion of the variance in 25(OH)D.</AbstractText><CopyrightInformation>©2013 AACR.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hiraki</LastName><ForeName>Linda T</ForeName><Initials>LT</Initials><AffiliationInfo><Affiliation>Authors' Affiliations: Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Departments of Nutrition, and Biostatistics, Harvard School of Public Health; Department of Medicine, and Channing Division of Network Medicine, Brigham and Women's Hospital; Division of Gastroenterology, Massachusetts General Hospital; Department of Medicine, Harvard Medical School; Gastrointestinal Malignancy Program, and Medical-Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; Public Health Sciences Division, Fred Hutchinson Cancer Research Center; Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington; Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, North Carolina; Divisions of Cancer Epidemiology and Genetics, and Cancer Control and Population Sciences, National Cancer Institute, NIH, Bethesda; University of Maryland, School of Medicine, Baltimore, Maryland; Service de Génétique Médicale, CHU Nantes, Nantes, France; Divisions of Clinical Epidemiology and Aging Research and Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany; Division of Research, Kaiser Permanente Medical Care Program, Oakland; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; Translational Genomics Research Institute, Phoenix, Arizona; Department of Surgery, Toronto General Hospital; Ontario Institute for Cancer Research; Departments of Medical Biophysics and Molecular Genetics, University of Toronto, Toronto; Faculty of Medicine, The University of Ottawa, Ottawa, Ontario, Canada; Department of Environmental Medicine, Division of Epidemiology, New York University School of Medicine, New York; Department of Social and Preventive Medicine, University of Buffalo, Buffalo, New York; Melborne School of Population Health, The University of Melbourne, Melbourne, Victoria, Australia; Epidemiology Pro</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Qu</LastName><ForeName>Conghui</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Hutter</LastName><ForeName>Carolyn M</ForeName><Initials>CM</Initials></Author><Author ValidYN="Y"><LastName>Baron</LastName><ForeName>John A</ForeName><Initials>JA</Initials></Author><Author ValidYN="Y"><LastName>Berndt</LastName><ForeName>Sonja I</ForeName><Initials>SI</Initials></Author><Author ValidYN="Y"><LastName>Bézieau</LastName><ForeName>Stéphane</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Brenner</LastName><ForeName>Hermann</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Caan</LastName><ForeName>Bette J</ForeName><Initials>BJ</Initials></Author><Author ValidYN="Y"><LastName>Casey</LastName><ForeName>Graham</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Chang-Claude</LastName><ForeName>Jenny</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Chanock</LastName><ForeName>Stephen J</ForeName><Initials>SJ</Initials></Author><Author ValidYN="Y"><LastName>Conti</LastName><ForeName>David V</ForeName><Initials>DV</Initials></Author><Author ValidYN="Y"><LastName>Duggan</LastName><ForeName>David</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Fuchs</LastName><ForeName>Charles S</ForeName><Initials>CS</Initials></Author><Author ValidYN="Y"><LastName>Gallinger</LastName><ForeName>Steven</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Giovannucci</LastName><ForeName>Edward L</ForeName><Initials>EL</Initials></Author><Author ValidYN="Y"><LastName>Harrison</LastName><ForeName>Tabitha A</ForeName><Initials>TA</Initials></Author><Author ValidYN="Y"><LastName>Hayes</LastName><ForeName>Richard B</ForeName><Initials>RB</Initials></Author><Author ValidYN="Y"><LastName>Hazra</LastName><ForeName>Aditi</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Henderson</LastName><ForeName>Brian</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Hoffmeister</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Hopper</LastName><ForeName>John L</ForeName><Initials>JL</Initials></Author><Author ValidYN="Y"><LastName>Hudson</LastName><ForeName>Thomas J</ForeName><Initials>TJ</Initials></Author><Author ValidYN="Y"><LastName>Jenkins</LastName><ForeName>Mark A</ForeName><Initials>MA</Initials></Author><Author ValidYN="Y"><LastName>Küry</LastName><ForeName>Sébastien</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Le Marchand</LastName><ForeName>Loic</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Lemire</LastName><ForeName>Mathieu</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Ma</LastName><ForeName>Jing</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Manson</LastName><ForeName>Joann E</ForeName><Initials>JE</Initials></Author><Author ValidYN="Y"><LastName>Nan</LastName><ForeName>Hongmei</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Newcomb</LastName><ForeName>Polly A</ForeName><Initials>PA</Initials></Author><Author ValidYN="Y"><LastName>Ng</LastName><ForeName>Kimmie</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Potter</LastName><ForeName>John D</ForeName><Initials>JD</Initials></Author><Author ValidYN="Y"><LastName>Schoen</LastName><ForeName>Robert E</ForeName><Initials>RE</Initials></Author><Author ValidYN="Y"><LastName>Schumacher</LastName><ForeName>Fredrick R</ForeName><Initials>FR</Initials></Author><Author ValidYN="Y"><LastName>Seminara</LastName><ForeName>Daniela</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Slattery</LastName><ForeName>Martha L</ForeName><Initials>ML</Initials></Author><Author ValidYN="Y"><LastName>Wactawski-Wende</LastName><ForeName>Jean</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>White</LastName><ForeName>Emily</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Kana</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Zanke</LastName><ForeName>Brent W</ForeName><Initials>BW</Initials></Author><Author ValidYN="Y"><LastName>Kraft</LastName><ForeName>Peter</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Peters</LastName><ForeName>Ulrike</ForeName><Initials>U</Initials></Author><Author ValidYN="Y"><LastName>Chan</LastName><ForeName>Andrew T</ForeName><Initials>AT</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>CA167552</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>K07 CA148894</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA059045</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100001I</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA60987</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 HG004438</GrantID><Acronym>HG</Acronym><Agency>NHGRI NIH 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CA154337</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U24 CA074783</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P01 CA055075</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100046C</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 137178</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA048998</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R25 CA094880</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 CA137088</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100003C</GrantID><Acronym>WH</Acronym><Agency>WHI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U24 CA074794</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U24 CA074806</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA137178</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U24 CA097735</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 CA074794</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R37 CA54281</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>K24 DK098311</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA48998</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><Agency>Canadian Institutes of Health Research</Agency><Country>Canada</Country></Grant><Grant><GrantID>P01 CA 055075</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P50CA127003</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN271201100004C</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA063464</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P01 CA033619</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100002C</GrantID><Acronym>WH</Acronym><Agency>WHI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA042182</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA060987</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 CA097735</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>CA42182</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UM1 CA167552</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>K05 CA152715</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UM1 CA167551</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 CA122839</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100002I</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA63464</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 CA074783</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 CA074806</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U24 CA074800</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P50 CA127003</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01CA074783</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R37 CA054281</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 CA074800</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100001C</GrantID><Acronym>WH</Acronym><Agency>WHI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100004C</GrantID><Acronym>WH</Acronym><Agency>WHI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>08</Month><Day>27</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Cancer Epidemiol Biomarkers Prev</MedlineTA><NlmUniqueID>9200608</NlmUniqueID><ISSNLinking>1055-9965</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>1406-16-2</RegistryNumber><NameOfSubstance UI="D014807">Vitamin D</NameOfSubstance></Chemical><Chemical><RegistryNumber>64719-49-9</RegistryNumber><NameOfSubstance UI="C104450">25-hydroxyvitamin D</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Am J Prev Med. 2007 Mar;32(3):210-6</RefSource><PMID Version="1">17296473</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genet Epidemiol. 2013 Jan;37(1):92-8</RefSource><PMID Version="1">23135809</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Natl Cancer Inst. 2007 Jul 18;99(14):1120-9</RefSource><PMID Version="1">17623801</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Med. 2008 Aug 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May;20(5):758-66</RefSource><PMID Version="1">21357381</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D015179" MajorTopicYN="N">Colorectal Neoplasms</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004032" MajorTopicYN="N">Diet</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020022" MajorTopicYN="N">Genetic Predisposition to Disease</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005838" MajorTopicYN="N">Genotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020641" MajorTopicYN="N">Polymorphism, Single Nucleotide</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014807" MajorTopicYN="N">Vitamin D</DescriptorName><QualifierName UI="Q000031" MajorTopicYN="Y">analogs & derivatives</QualifierName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">NIHMS519199</OtherID><OtherID Source="NLM">PMC3818310</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>8</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>8</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>8</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23983240</ArticleId><ArticleId IdType="pii">1055-9965.EPI-13-0209</ArticleId><ArticleId IdType="doi">10.1158/1055-9965.EPI-13-0209</ArticleId><ArticleId IdType="pmc">PMC3818310</ArticleId><ArticleId IdType="mid">NIHMS519199</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li></country></list><tree><noCountry><name sortKey="Baron, John A" sort="Baron, John A" uniqKey="Baron J" first="John A" last="Baron">John A. Baron</name><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I" last="Berndt">Sonja I. Berndt</name><name sortKey="Bezieau, Stephane" sort="Bezieau, Stephane" uniqKey="Bezieau S" first="Stéphane" last="Bézieau">Stéphane Bézieau</name><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><name sortKey="Caan, Bette J" sort="Caan, Bette J" uniqKey="Caan B" first="Bette J" last="Caan">Bette J. Caan</name><name sortKey="Casey, Graham" sort="Casey, Graham" uniqKey="Casey G" first="Graham" last="Casey">Graham Casey</name><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T" last="Chan">Andrew T. Chan</name><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J" last="Chanock">Stephen J. Chanock</name><name sortKey="Conti, David V" sort="Conti, David V" uniqKey="Conti D" first="David V" last="Conti">David V. Conti</name><name sortKey="Duggan, David" sort="Duggan, David" uniqKey="Duggan D" first="David" last="Duggan">David Duggan</name><name sortKey="Fuchs, Charles S" sort="Fuchs, Charles S" uniqKey="Fuchs C" first="Charles S" last="Fuchs">Charles S. Fuchs</name><name sortKey="Gallinger, Steven" sort="Gallinger, Steven" uniqKey="Gallinger S" first="Steven" last="Gallinger">Steven Gallinger</name><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L" last="Giovannucci">Edward L. Giovannucci</name><name sortKey="Harrison, Tabitha A" sort="Harrison, Tabitha A" uniqKey="Harrison T" first="Tabitha A" last="Harrison">Tabitha A. Harrison</name><name sortKey="Hayes, Richard B" sort="Hayes, Richard B" uniqKey="Hayes R" first="Richard B" last="Hayes">Richard B. Hayes</name><name sortKey="Hazra, Aditi" sort="Hazra, Aditi" uniqKey="Hazra A" first="Aditi" last="Hazra">Aditi Hazra</name><name sortKey="Henderson, Brian" sort="Henderson, Brian" uniqKey="Henderson B" first="Brian" last="Henderson">Brian Henderson</name><name sortKey="Hoffmeister, Michael" sort="Hoffmeister, Michael" uniqKey="Hoffmeister M" first="Michael" last="Hoffmeister">Michael Hoffmeister</name><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name><name sortKey="Hudson, Thomas J" sort="Hudson, Thomas J" uniqKey="Hudson T" first="Thomas J" last="Hudson">Thomas J. Hudson</name><name sortKey="Hutter, Carolyn M" sort="Hutter, Carolyn M" uniqKey="Hutter C" first="Carolyn M" last="Hutter">Carolyn M. Hutter</name><name sortKey="Jenkins, Mark A" sort="Jenkins, Mark A" uniqKey="Jenkins M" first="Mark A" last="Jenkins">Mark A. Jenkins</name><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><name sortKey="Kury, Sebastien" sort="Kury, Sebastien" uniqKey="Kury S" first="Sébastien" last="Küry">Sébastien Küry</name><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><name sortKey="Lemire, Mathieu" sort="Lemire, Mathieu" uniqKey="Lemire M" first="Mathieu" last="Lemire">Mathieu Lemire</name><name sortKey="Ma, Jing" sort="Ma, Jing" uniqKey="Ma J" first="Jing" last="Ma">Jing Ma</name><name sortKey="Manson, Joann E" sort="Manson, Joann E" uniqKey="Manson J" first="Joann E" last="Manson">Joann E. Manson</name><name sortKey="Nan, Hongmei" sort="Nan, Hongmei" uniqKey="Nan H" first="Hongmei" last="Nan">Hongmei Nan</name><name sortKey="Newcomb, Polly A" sort="Newcomb, Polly A" uniqKey="Newcomb P" first="Polly A" last="Newcomb">Polly A. Newcomb</name><name sortKey="Ng, Kimmie" sort="Ng, Kimmie" uniqKey="Ng K" first="Kimmie" last="Ng">Kimmie Ng</name><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><name sortKey="Potter, John D" sort="Potter, John D" uniqKey="Potter J" first="John D" last="Potter">John D. Potter</name><name sortKey="Qu, Conghui" sort="Qu, Conghui" uniqKey="Qu C" first="Conghui" last="Qu">Conghui Qu</name><name sortKey="Schoen, Robert E" sort="Schoen, Robert E" uniqKey="Schoen R" first="Robert E" last="Schoen">Robert E. Schoen</name><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R" last="Schumacher">Fredrick R. Schumacher</name><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name><name sortKey="Slattery, Martha L" sort="Slattery, Martha L" uniqKey="Slattery M" first="Martha L" last="Slattery">Martha L. Slattery</name><name sortKey="Wactawski Wende, Jean" sort="Wactawski Wende, Jean" uniqKey="Wactawski Wende J" first="Jean" last="Wactawski-Wende">Jean Wactawski-Wende</name><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name><name sortKey="Wu, Kana" sort="Wu, Kana" uniqKey="Wu K" first="Kana" last="Wu">Kana Wu</name><name sortKey="Zanke, Brent W" sort="Zanke, Brent W" uniqKey="Zanke B" first="Brent W" last="Zanke">Brent W. Zanke</name></noCountry><country name="Australie"><noRegion><name sortKey="Hiraki, Linda T" sort="Hiraki, Linda T" uniqKey="Hiraki L" first="Linda T" last="Hiraki">Linda T. 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