Urinary interleukin-8 is a biomarker of stress in emergency physicians, especially with advancing age--the JOBSTRESS* randomized trial.
Identifieur interne : 003883 ( PubMed/Checkpoint ); précédent : 003882; suivant : 003884Urinary interleukin-8 is a biomarker of stress in emergency physicians, especially with advancing age--the JOBSTRESS* randomized trial.
Auteurs : Frédéric Dutheil [France] ; Marion Trousselard ; Christophe Perrier ; Gérard Lac ; Alain Chamoux ; Martine Duclos ; Geraldine Naughton ; George Mnatzaganian ; Jeannot SchmidtSource :
- PloS one [ 1932-6203 ] ; 2013.
Descripteurs français
- KwdFr :
- Adulte, Analyse de régression, Analyse multivariée, Facteurs de l'âge, Fatigue (urine), Femelle, Humains, Interleukine-8 (urine), Marqueurs biologiques (urine), Mâle, Médecins, Service hospitalier d'urgences, Sommeil, Stress psychologique (physiopathologie), Stress psychologique (urine), Vieillissement (urine), Épuisement professionnel (physiopathologie), Épuisement professionnel (urine), Études de suivi.
- MESH :
- physiopathologie : Stress psychologique, Épuisement professionnel.
- urine : Adulte, Analyse de régression, Analyse multivariée, Facteurs de l'âge, Fatigue, Femelle, Humains, Interleukine-8, Marqueurs biologiques, Mâle, Médecins, Service hospitalier d'urgences, Sommeil, Stress psychologique, Vieillissement, Épuisement professionnel, Études de suivi.
English descriptors
- KwdEn :
- Adult, Age Factors, Aging (urine), Biomarkers (urine), Burnout, Professional (physiopathology), Burnout, Professional (urine), Emergency Service, Hospital, Fatigue (urine), Female, Follow-Up Studies, Humans, Interleukin-8 (urine), Male, Multivariate Analysis, Physicians, Regression Analysis, Sleep, Stress, Psychological (physiopathology), Stress, Psychological (urine).
- MESH :
- chemical , urine : Biomarkers, Interleukin-8.
- physiopathology : Burnout, Professional, Stress, Psychological.
- urine : Aging, Burnout, Professional, Fatigue, Stress, Psychological.
- Adult, Age Factors, Emergency Service, Hospital, Female, Follow-Up Studies, Humans, Male, Multivariate Analysis, Physicians, Regression Analysis, Sleep.
Abstract
Emergency physicians are exposed to greater stress during a 24-hour shift (24 hS) than a 14-hour night shift (14 hS), with an impact lasting several days. Interleukin-8 (IL-8) is postulated to be a chronic stress biomarker. However, no studies have tracked IL-8 over several shifts or used it for monitoring short-term residual stress. The IL-8 response to the shifts may also increase with age. Conveniently, IL-8 can be measured non-intrusively from urine.
DOI: 10.1371/journal.pone.0071658
PubMed: 23977105
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:23977105Le document en format XML
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Montpied Hospital, Clermont-Ferrand, France ; Department of Occupational Medicine, University Hospital (CHU), G. Montpied Hospital, Clermont-Ferrand, France ; Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological Conditions EA3533, Blaise Pascal University, Clermont-Ferrand, France ; School of Exercise Science, Australian Catholic University, Melbourne, Victoria, Australia ; Department of Sport Medicine and Functional Exploration, University Hospital (CHU), G. Montpied Hospital, Clermont-Ferrand, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Emergency Department, University Hospital (CHU), G. Montpied Hospital, Clermont-Ferrand, France ; Department of Occupational Medicine, University Hospital (CHU), G. Montpied Hospital, Clermont-Ferrand, France ; Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological Conditions EA3533, Blaise Pascal University, Clermont-Ferrand, France ; School of Exercise Science, Australian Catholic University, Melbourne, Victoria, Australia ; Department of Sport Medicine and Functional Exploration, University Hospital (CHU), G. Montpied Hospital, Clermont-Ferrand</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Trousselard, Marion" sort="Trousselard, Marion" uniqKey="Trousselard M" first="Marion" last="Trousselard">Marion Trousselard</name></author><author><name sortKey="Perrier, Christophe" sort="Perrier, Christophe" uniqKey="Perrier C" first="Christophe" last="Perrier">Christophe Perrier</name></author><author><name sortKey="Lac, Gerard" sort="Lac, Gerard" uniqKey="Lac G" first="Gérard" last="Lac">Gérard Lac</name></author><author><name sortKey="Chamoux, Alain" sort="Chamoux, Alain" uniqKey="Chamoux A" first="Alain" last="Chamoux">Alain Chamoux</name></author><author><name sortKey="Duclos, Martine" sort="Duclos, Martine" uniqKey="Duclos M" first="Martine" last="Duclos">Martine Duclos</name></author><author><name sortKey="Naughton, Geraldine" sort="Naughton, Geraldine" uniqKey="Naughton G" first="Geraldine" last="Naughton">Geraldine Naughton</name></author><author><name sortKey="Mnatzaganian, George" sort="Mnatzaganian, George" uniqKey="Mnatzaganian G" first="George" last="Mnatzaganian">George Mnatzaganian</name></author><author><name sortKey="Schmidt, Jeannot" sort="Schmidt, Jeannot" uniqKey="Schmidt J" first="Jeannot" last="Schmidt">Jeannot Schmidt</name></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Aging (urine)</term><term>Biomarkers (urine)</term><term>Burnout, Professional (physiopathology)</term><term>Burnout, Professional (urine)</term><term>Emergency Service, Hospital</term><term>Fatigue (urine)</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Interleukin-8 (urine)</term><term>Male</term><term>Multivariate Analysis</term><term>Physicians</term><term>Regression Analysis</term><term>Sleep</term><term>Stress, Psychological (physiopathology)</term><term>Stress, Psychological (urine)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Analyse de régression</term><term>Analyse multivariée</term><term>Facteurs de l'âge</term><term>Fatigue (urine)</term><term>Femelle</term><term>Humains</term><term>Interleukine-8 (urine)</term><term>Marqueurs biologiques (urine)</term><term>Mâle</term><term>Médecins</term><term>Service hospitalier d'urgences</term><term>Sommeil</term><term>Stress psychologique (physiopathologie)</term><term>Stress psychologique (urine)</term><term>Vieillissement (urine)</term><term>Épuisement professionnel (physiopathologie)</term><term>Épuisement professionnel (urine)</term><term>Études de suivi</term></keywords><keywords scheme="MESH" type="chemical" qualifier="urine" xml:lang="en"><term>Biomarkers</term><term>Interleukin-8</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Stress psychologique</term><term>Épuisement professionnel</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Burnout, Professional</term><term>Stress, Psychological</term></keywords><keywords scheme="MESH" qualifier="urine" xml:lang="en"><term>Aging</term><term>Burnout, Professional</term><term>Fatigue</term><term>Stress, Psychological</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Emergency Service, Hospital</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Multivariate Analysis</term><term>Physicians</term><term>Regression Analysis</term><term>Sleep</term></keywords><keywords scheme="MESH" qualifier="urine" xml:lang="fr"><term>Adulte</term><term>Analyse de régression</term><term>Analyse multivariée</term><term>Facteurs de l'âge</term><term>Fatigue</term><term>Femelle</term><term>Humains</term><term>Interleukine-8</term><term>Marqueurs biologiques</term><term>Mâle</term><term>Médecins</term><term>Service hospitalier d'urgences</term><term>Sommeil</term><term>Stress psychologique</term><term>Vieillissement</term><term>Épuisement professionnel</term><term>Études de suivi</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Emergency physicians are exposed to greater stress during a 24-hour shift (24 hS) than a 14-hour night shift (14 hS), with an impact lasting several days. Interleukin-8 (IL-8) is postulated to be a chronic stress biomarker. However, no studies have tracked IL-8 over several shifts or used it for monitoring short-term residual stress. The IL-8 response to the shifts may also increase with age. Conveniently, IL-8 can be measured non-intrusively from urine.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23977105</PMID><DateCreated><Year>2013</Year><Month>08</Month><Day>26</Day></DateCreated><DateCompleted><Year>2014</Year><Month>04</Month><Day>08</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>8</Volume><Issue>8</Issue><PubDate><Year>2013</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS ONE</ISOAbbreviation></Journal><ArticleTitle>Urinary interleukin-8 is a biomarker of stress in emergency physicians, especially with advancing age--the JOBSTRESS* randomized trial.</ArticleTitle><Pagination><MedlinePgn>e71658</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0071658</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Emergency physicians are exposed to greater stress during a 24-hour shift (24 hS) than a 14-hour night shift (14 hS), with an impact lasting several days. Interleukin-8 (IL-8) is postulated to be a chronic stress biomarker. However, no studies have tracked IL-8 over several shifts or used it for monitoring short-term residual stress. The IL-8 response to the shifts may also increase with age. Conveniently, IL-8 can be measured non-intrusively from urine.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We conducted a shifts-randomized trial comparing 17 emergency physicians' urinary IL-8 levels during a 24 hS, a 14 hS, and a control day (clerical work on return from leave). Mean levels of IL-8 were compared using a Wilcoxon matched-pairs test. Independent associations of key factors including shifts, stress, and age with IL-8 levels were further assessed in a multivariable generalized estimating equations model.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Mean urinary IL-8 levels almost doubled during and after a 24 hS compared with a 14 hS or a control day. Furthermore, IL-8 levels failed to return to control values at the end of the third day after the shift despite a rest day following the 24 hS. In the multivariable model, engaging in a 24 hS, self-reported stress, and age were independently associated with higher IL-8 levels. A 24 hS significantly increased IL-8 levels by 1.9 ng (p = .007). Similarly, for every unit increase in self-reported stress, there was a 0.11 ng increase in IL-8 levels (p = .003); and for every one year advance in age of physicians, IL-8 levels also increased by 0.11 ng (p = .018).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The 24 hS generated a prolonged response of the immune system. Urinary IL-8 was a strong biomarker of stress under intensive and prolonged demands, both acutely and over time. Because elevated IL-8 levels are associated with cardiovascular disease and negative psychological consequences, we suggest that emergency physicians limit their exposure to 24 hS, especially with advancing age.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dutheil</LastName><ForeName>Frédéric</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Emergency Department, University Hospital (CHU), G. Montpied Hospital, Clermont-Ferrand, France ; Department of Occupational Medicine, University Hospital (CHU), G. Montpied Hospital, Clermont-Ferrand, France ; Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological Conditions EA3533, Blaise Pascal University, Clermont-Ferrand, France ; School of Exercise Science, Australian Catholic University, Melbourne, Victoria, Australia ; Department of Sport Medicine and Functional Exploration, University Hospital (CHU), G. Montpied Hospital, Clermont-Ferrand, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Trousselard</LastName><ForeName>Marion</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Perrier</LastName><ForeName>Christophe</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Lac</LastName><ForeName>Gérard</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Chamoux</LastName><ForeName>Alain</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Duclos</LastName><ForeName>Martine</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Naughton</LastName><ForeName>Geraldine</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Mnatzaganian</LastName><ForeName>George</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Schmidt</LastName><ForeName>Jeannot</ForeName><Initials>J</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>08</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C508606">IL8 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance 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MajorTopicYN="N">Stress, Psychological</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName><QualifierName UI="Q000652" MajorTopicYN="Y">urine</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC3747272</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>04</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>06</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>8</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>8</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>4</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23977105</ArticleId><ArticleId IdType="doi">10.1371/journal.pone.0071658</ArticleId><ArticleId IdType="pii">PONE-D-13-15870</ArticleId><ArticleId IdType="pmc">PMC3747272</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Auvergne (région administrative)</li><li>Auvergne-Rhône-Alpes</li></region><settlement><li>Clermont-Ferrand</li></settlement></list><tree><noCountry><name sortKey="Chamoux, Alain" sort="Chamoux, Alain" uniqKey="Chamoux A" first="Alain" last="Chamoux">Alain Chamoux</name><name sortKey="Duclos, Martine" sort="Duclos, Martine" uniqKey="Duclos M" first="Martine" last="Duclos">Martine Duclos</name><name sortKey="Lac, Gerard" sort="Lac, Gerard" uniqKey="Lac G" first="Gérard" last="Lac">Gérard Lac</name><name sortKey="Mnatzaganian, George" sort="Mnatzaganian, George" uniqKey="Mnatzaganian G" first="George" last="Mnatzaganian">George Mnatzaganian</name><name sortKey="Naughton, Geraldine" sort="Naughton, Geraldine" uniqKey="Naughton G" first="Geraldine" last="Naughton">Geraldine Naughton</name><name sortKey="Perrier, Christophe" sort="Perrier, Christophe" uniqKey="Perrier C" first="Christophe" last="Perrier">Christophe Perrier</name><name sortKey="Schmidt, Jeannot" sort="Schmidt, Jeannot" uniqKey="Schmidt J" first="Jeannot" last="Schmidt">Jeannot Schmidt</name><name sortKey="Trousselard, Marion" sort="Trousselard, Marion" uniqKey="Trousselard M" first="Marion" last="Trousselard">Marion Trousselard</name></noCountry><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Dutheil, Frederic" sort="Dutheil, Frederic" uniqKey="Dutheil F" first="Frédéric" last="Dutheil">Frédéric Dutheil</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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