Urinary interleukin-8 is a biomarker of stress in emergency physicians, especially with advancing age--the JOBSTRESS* randomized trial.
Identifieur interne : 003883 ( PubMed/Checkpoint ); précédent : 003882; suivant : 003884Urinary interleukin-8 is a biomarker of stress in emergency physicians, especially with advancing age--the JOBSTRESS* randomized trial.
Auteurs : Frédéric Dutheil [France] ; Marion Trousselard ; Christophe Perrier ; Gérard Lac ; Alain Chamoux ; Martine Duclos ; Geraldine Naughton ; George Mnatzaganian ; Jeannot SchmidtSource :
- PloS one [ 1932-6203 ] ; 2013.
Descripteurs français
- KwdFr :
- Adulte, Analyse de régression, Analyse multivariée, Facteurs de l'âge, Fatigue (urine), Femelle, Humains, Interleukine-8 (urine), Marqueurs biologiques (urine), Mâle, Médecins, Service hospitalier d'urgences, Sommeil, Stress psychologique (physiopathologie), Stress psychologique (urine), Vieillissement (urine), Épuisement professionnel (physiopathologie), Épuisement professionnel (urine), Études de suivi.
- MESH :
- physiopathologie : Stress psychologique, Épuisement professionnel.
- urine : Adulte, Analyse de régression, Analyse multivariée, Facteurs de l'âge, Fatigue, Femelle, Humains, Interleukine-8, Marqueurs biologiques, Mâle, Médecins, Service hospitalier d'urgences, Sommeil, Stress psychologique, Vieillissement, Épuisement professionnel, Études de suivi.
English descriptors
- KwdEn :
- Adult, Age Factors, Aging (urine), Biomarkers (urine), Burnout, Professional (physiopathology), Burnout, Professional (urine), Emergency Service, Hospital, Fatigue (urine), Female, Follow-Up Studies, Humans, Interleukin-8 (urine), Male, Multivariate Analysis, Physicians, Regression Analysis, Sleep, Stress, Psychological (physiopathology), Stress, Psychological (urine).
- MESH :
- chemical , urine : Biomarkers, Interleukin-8.
- physiopathology : Burnout, Professional, Stress, Psychological.
- urine : Aging, Burnout, Professional, Fatigue, Stress, Psychological.
- Adult, Age Factors, Emergency Service, Hospital, Female, Follow-Up Studies, Humans, Male, Multivariate Analysis, Physicians, Regression Analysis, Sleep.
Abstract
Emergency physicians are exposed to greater stress during a 24-hour shift (24 hS) than a 14-hour night shift (14 hS), with an impact lasting several days. Interleukin-8 (IL-8) is postulated to be a chronic stress biomarker. However, no studies have tracked IL-8 over several shifts or used it for monitoring short-term residual stress. The IL-8 response to the shifts may also increase with age. Conveniently, IL-8 can be measured non-intrusively from urine.
DOI: 10.1371/journal.pone.0071658
PubMed: 23977105
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:23977105Le document en format XML
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<term>Age Factors</term>
<term>Aging (urine)</term>
<term>Biomarkers (urine)</term>
<term>Burnout, Professional (physiopathology)</term>
<term>Burnout, Professional (urine)</term>
<term>Emergency Service, Hospital</term>
<term>Fatigue (urine)</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Interleukin-8 (urine)</term>
<term>Male</term>
<term>Multivariate Analysis</term>
<term>Physicians</term>
<term>Regression Analysis</term>
<term>Sleep</term>
<term>Stress, Psychological (physiopathology)</term>
<term>Stress, Psychological (urine)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Analyse de régression</term>
<term>Analyse multivariée</term>
<term>Facteurs de l'âge</term>
<term>Fatigue (urine)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Interleukine-8 (urine)</term>
<term>Marqueurs biologiques (urine)</term>
<term>Mâle</term>
<term>Médecins</term>
<term>Service hospitalier d'urgences</term>
<term>Sommeil</term>
<term>Stress psychologique (physiopathologie)</term>
<term>Stress psychologique (urine)</term>
<term>Vieillissement (urine)</term>
<term>Épuisement professionnel (physiopathologie)</term>
<term>Épuisement professionnel (urine)</term>
<term>Études de suivi</term>
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<term>Interleukin-8</term>
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<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Stress psychologique</term>
<term>Épuisement professionnel</term>
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<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Burnout, Professional</term>
<term>Stress, Psychological</term>
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<term>Burnout, Professional</term>
<term>Fatigue</term>
<term>Stress, Psychological</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Age Factors</term>
<term>Emergency Service, Hospital</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Male</term>
<term>Multivariate Analysis</term>
<term>Physicians</term>
<term>Regression Analysis</term>
<term>Sleep</term>
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<term>Analyse de régression</term>
<term>Analyse multivariée</term>
<term>Facteurs de l'âge</term>
<term>Fatigue</term>
<term>Femelle</term>
<term>Humains</term>
<term>Interleukine-8</term>
<term>Marqueurs biologiques</term>
<term>Mâle</term>
<term>Médecins</term>
<term>Service hospitalier d'urgences</term>
<term>Sommeil</term>
<term>Stress psychologique</term>
<term>Vieillissement</term>
<term>Épuisement professionnel</term>
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<front><div type="abstract" xml:lang="en">Emergency physicians are exposed to greater stress during a 24-hour shift (24 hS) than a 14-hour night shift (14 hS), with an impact lasting several days. Interleukin-8 (IL-8) is postulated to be a chronic stress biomarker. However, no studies have tracked IL-8 over several shifts or used it for monitoring short-term residual stress. The IL-8 response to the shifts may also increase with age. Conveniently, IL-8 can be measured non-intrusively from urine.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23977105</PMID>
<DateCreated><Year>2013</Year>
<Month>08</Month>
<Day>26</Day>
</DateCreated>
<DateCompleted><Year>2014</Year>
<Month>04</Month>
<Day>08</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>02</Month>
<Day>20</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>8</Volume>
<Issue>8</Issue>
<PubDate><Year>2013</Year>
</PubDate>
</JournalIssue>
<Title>PloS one</Title>
<ISOAbbreviation>PLoS ONE</ISOAbbreviation>
</Journal>
<ArticleTitle>Urinary interleukin-8 is a biomarker of stress in emergency physicians, especially with advancing age--the JOBSTRESS* randomized trial.</ArticleTitle>
<Pagination><MedlinePgn>e71658</MedlinePgn>
</Pagination>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Emergency physicians are exposed to greater stress during a 24-hour shift (24 hS) than a 14-hour night shift (14 hS), with an impact lasting several days. Interleukin-8 (IL-8) is postulated to be a chronic stress biomarker. However, no studies have tracked IL-8 over several shifts or used it for monitoring short-term residual stress. The IL-8 response to the shifts may also increase with age. Conveniently, IL-8 can be measured non-intrusively from urine.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We conducted a shifts-randomized trial comparing 17 emergency physicians' urinary IL-8 levels during a 24 hS, a 14 hS, and a control day (clerical work on return from leave). Mean levels of IL-8 were compared using a Wilcoxon matched-pairs test. Independent associations of key factors including shifts, stress, and age with IL-8 levels were further assessed in a multivariable generalized estimating equations model.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Mean urinary IL-8 levels almost doubled during and after a 24 hS compared with a 14 hS or a control day. Furthermore, IL-8 levels failed to return to control values at the end of the third day after the shift despite a rest day following the 24 hS. In the multivariable model, engaging in a 24 hS, self-reported stress, and age were independently associated with higher IL-8 levels. A 24 hS significantly increased IL-8 levels by 1.9 ng (p = .007). Similarly, for every unit increase in self-reported stress, there was a 0.11 ng increase in IL-8 levels (p = .003); and for every one year advance in age of physicians, IL-8 levels also increased by 0.11 ng (p = .018).</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The 24 hS generated a prolonged response of the immune system. Urinary IL-8 was a strong biomarker of stress under intensive and prolonged demands, both acutely and over time. Because elevated IL-8 levels are associated with cardiovascular disease and negative psychological consequences, we suggest that emergency physicians limit their exposure to 24 hS, especially with advancing age.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dutheil</LastName>
<ForeName>Frédéric</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Emergency Department, University Hospital (CHU), G. Montpied Hospital, Clermont-Ferrand, France ; Department of Occupational Medicine, University Hospital (CHU), G. Montpied Hospital, Clermont-Ferrand, France ; Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological Conditions EA3533, Blaise Pascal University, Clermont-Ferrand, France ; School of Exercise Science, Australian Catholic University, Melbourne, Victoria, Australia ; Department of Sport Medicine and Functional Exploration, University Hospital (CHU), G. Montpied Hospital, Clermont-Ferrand, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Trousselard</LastName>
<ForeName>Marion</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Perrier</LastName>
<ForeName>Christophe</ForeName>
<Initials>C</Initials>
</Author>
<Author ValidYN="Y"><LastName>Lac</LastName>
<ForeName>Gérard</ForeName>
<Initials>G</Initials>
</Author>
<Author ValidYN="Y"><LastName>Chamoux</LastName>
<ForeName>Alain</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Duclos</LastName>
<ForeName>Martine</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Naughton</LastName>
<ForeName>Geraldine</ForeName>
<Initials>G</Initials>
</Author>
<Author ValidYN="Y"><LastName>Mnatzaganian</LastName>
<ForeName>George</ForeName>
<Initials>G</Initials>
</Author>
<Author ValidYN="Y"><LastName>Schmidt</LastName>
<ForeName>Jeannot</ForeName>
<Initials>J</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016449">Randomized Controlled Trial</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2013</Year>
<Month>08</Month>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C508606">IL8 protein, human</NameOfSubstance>
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<NameOfSubstance UI="D016209">Interleukin-8</NameOfSubstance>
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