Degree of blood pressure reduction and recurrent stroke: the PROGRESS trial.
Identifieur interne : 003693 ( PubMed/Checkpoint ); précédent : 003692; suivant : 003694Degree of blood pressure reduction and recurrent stroke: the PROGRESS trial.
Auteurs : Hisatomi Arima [Australie] ; Craig Anderson [Australie] ; Teruo Omae [Japon] ; Mark Woodward [Australie] ; Stephen Macmahon [Royaume-Uni] ; Giuseppe Mancia [Italie] ; Marie-Germaine Bousser [France] ; Christophe Tzourio [France] ; Stephen Harrap [Australie] ; Lisheng Liu [République populaire de Chine] ; Bruce Neal [Australie] ; John Chalmers [Australie]Source :
- Journal of neurology, neurosurgery, and psychiatry [ 1468-330X ] ; 2014.
Descripteurs français
- KwdFr :
- Accident vasculaire cérébral (physiopathologie), Accident vasculaire cérébral (étiologie), Adulte d'âge moyen, Antihypertenseurs (usage thérapeutique), Facteurs de risque, Femelle, Humains, Hypertension artérielle (), Hypertension artérielle (traitement médicamenteux), Mâle, Pression sanguine (physiologie), Périndopril (usage thérapeutique), Récidive.
- MESH :
- physiologie : Pression sanguine.
- physiopathologie : Accident vasculaire cérébral.
- traitement médicamenteux : Hypertension artérielle.
- usage thérapeutique : Antihypertenseurs, Périndopril.
- étiologie : Accident vasculaire cérébral.
- Adulte d'âge moyen, Facteurs de risque, Femelle, Humains, Hypertension artérielle, Mâle, Récidive.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Antihypertensive Agents, Perindopril.
- complications : Hypertension.
- drug therapy : Hypertension.
- etiology : Stroke.
- physiology : Blood Pressure.
- physiopathology : Stroke.
- Female, Humans, Male, Middle Aged, Recurrence, Risk Factors.
Abstract
There is ongoing controversy regarding a 'J-curve' phenomenon such that low and high blood pressure (BP) levels are associated with increased risks of recurrent stroke. We aimed to determine whether large treatment-related BP reductions are associated with increased risks of recurrent stroke.
DOI: 10.1136/jnnp-2014-307856
PubMed: 24828894
Affiliations:
- Australie, France, Italie, Japon, Royaume-Uni, République populaire de Chine
- Angleterre, Aquitaine, Lombardie, Nouvelle-Aquitaine, Nouvelle-Galles du Sud, Oxfordshire, Victoria (État), Île-de-France
- Bordeaux, Melbourne, Milan, Oxford, Paris, Pékin, Sydney
- Université de Melbourne, Université de Sydney
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:24828894Le document en format XML
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<front><div type="abstract" xml:lang="en">There is ongoing controversy regarding a 'J-curve' phenomenon such that low and high blood pressure (BP) levels are associated with increased risks of recurrent stroke. We aimed to determine whether large treatment-related BP reductions are associated with increased risks of recurrent stroke.</div>
</front>
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<DateCreated><Year>2014</Year>
<Month>10</Month>
<Day>18</Day>
</DateCreated>
<DateCompleted><Year>2015</Year>
<Month>01</Month>
<Day>26</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>11</Month>
<Day>14</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1468-330X</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>85</Volume>
<Issue>11</Issue>
<PubDate><Year>2014</Year>
<Month>Nov</Month>
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<Title>Journal of neurology, neurosurgery, and psychiatry</Title>
<ISOAbbreviation>J. Neurol. Neurosurg. Psychiatry</ISOAbbreviation>
</Journal>
<ArticleTitle>Degree of blood pressure reduction and recurrent stroke: the PROGRESS trial.</ArticleTitle>
<Pagination><MedlinePgn>1284-5</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1136/jnnp-2014-307856</ELocationID>
<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">There is ongoing controversy regarding a 'J-curve' phenomenon such that low and high blood pressure (BP) levels are associated with increased risks of recurrent stroke. We aimed to determine whether large treatment-related BP reductions are associated with increased risks of recurrent stroke.</AbstractText>
<AbstractText Label="DESIGN" NlmCategory="METHODS">Data are from the PROGRESS trial, where 6105 patients with cerebrovascular disease were randomly assigned to either active treatment (perindopril ± indapamide) or placebo(s). There were no BP criteria for entry. BP was measured at every visit, and participant groups defined by reduction in systolic BP (SBP) from baseline were used for the analyses. Outcome was recurrent stroke.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">During a mean follow-up of 3.9 years, 727 recurrent strokes were observed. There were clear associations between the magnitude of SBP reduction and the risk of recurrent stroke. After adjustment for cardiovascular risk factors and randomised treatment, annual incidence was 2.08%, 2.10%, 2.31% and 2.96% for participant groups defined by SBP reductions of ≥ 20, 10-19, 0-9 and <0 mm Hg, respectively (p=0.0006 for trend).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The present analysis provided no evidence of an increase in recurrent stroke associated with larger reductions in SBP produced by treatment among patients with cerebrovascular disease.</AbstractText>
<CopyrightInformation>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Arima</LastName>
<ForeName>Hisatomi</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>The George Institute for Global Health, University of Sydney, Sydney, New South Wales, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Anderson</LastName>
<ForeName>Craig</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>The George Institute for Global Health, University of Sydney, Sydney, New South Wales, Australia.</Affiliation>
</AffiliationInfo>
</Author>
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<ForeName>Teruo</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>National Cerebral and Cardiovascular Center, Suita, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Woodward</LastName>
<ForeName>Mark</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>The George Institute for Global Health, University of Sydney, Sydney, New South Wales, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>MacMahon</LastName>
<ForeName>Stephen</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>The George Institute for Global Health, University of Sydney, Sydney, New South Wales, Australia George Centre of Healthcare Innovation, University of Oxford, Oxford, UK.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Mancia</LastName>
<ForeName>Giuseppe</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Università Milano-Bicocca, Ospedale San Gerardo, Milan, Italy.</Affiliation>
</AffiliationInfo>
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<ForeName>Marie-Germaine</ForeName>
<Initials>MG</Initials>
<AffiliationInfo><Affiliation>The Department of Neurology, Hôpital Lariboisière, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tzourio</LastName>
<ForeName>Christophe</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>INSERM U897, Bordeaux, France University of Bordeaux, Bordeaux, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Harrap</LastName>
<ForeName>Stephen</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Physiology, University of Melbourne, Melbourne, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Lisheng</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>National Centre for Cardiovascular Diseases, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Neal</LastName>
<ForeName>Bruce</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>The George Institute for Global Health, University of Sydney, Sydney, New South Wales, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chalmers</LastName>
<ForeName>John</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>The George Institute for Global Health, University of Sydney, Sydney, New South Wales, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><CollectiveName>PROGRESS Collaborative Group</CollectiveName>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016449">Randomized Controlled Trial</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2014</Year>
<Month>05</Month>
<Day>14</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>J Neurol Neurosurg Psychiatry</MedlineTA>
<NlmUniqueID>2985191R</NlmUniqueID>
<ISSNLinking>0022-3050</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000959">Antihypertensive Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>Y5GMK36KGY</RegistryNumber>
<NameOfSubstance UI="D020913">Perindopril</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000959" MajorTopicYN="N">Antihypertensive Agents</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001794" MajorTopicYN="N">Blood Pressure</DescriptorName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006973" MajorTopicYN="N">Hypertension</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
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<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
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<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
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<MeshHeading><DescriptorName UI="D012008" MajorTopicYN="N">Recurrence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName>
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<MeshHeading><DescriptorName UI="D020521" MajorTopicYN="N">Stroke</DescriptorName>
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<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Epidemiology</Keyword>
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