Exploiting differential expression of the IL-7 receptor on memory T cells to modulate immune responses.
Identifieur interne : 003592 ( PubMed/Checkpoint ); précédent : 003591; suivant : 003593Exploiting differential expression of the IL-7 receptor on memory T cells to modulate immune responses.
Auteurs : John J. Zaunders [Australie] ; Yves Lévy [France] ; Nabila Seddiki [France]Source :
- Cytokine & growth factor reviews [ 1879-0305 ] ; 2014.
Descripteurs français
- KwdFr :
- Activation des lymphocytes (immunologie), Humains, Interleukine-7 (biosynthèse), Interleukine-7 (immunologie), Interleukine-7 (usage thérapeutique), Lymphocytes T régulateurs (immunologie), Lymphopénie (immunologie), Mémoire immunologique (immunologie), Sous-unité alpha du récepteur à l'interleukine-7 (biosynthèse), Sous-unité alpha du récepteur à l'interleukine-7 (immunologie), Transduction du signal (immunologie), Tumeurs ().
- MESH :
- biosynthèse : Interleukine-7, Sous-unité alpha du récepteur à l'interleukine-7.
- immunologie : Activation des lymphocytes, Interleukine-7, Lymphocytes T régulateurs, Lymphopénie, Mémoire immunologique, Sous-unité alpha du récepteur à l'interleukine-7, Transduction du signal.
- usage thérapeutique : Interleukine-7.
- Humains, Tumeurs.
English descriptors
- KwdEn :
- Humans, Immunologic Memory (immunology), Interleukin-7 (biosynthesis), Interleukin-7 (immunology), Interleukin-7 (therapeutic use), Interleukin-7 Receptor alpha Subunit (biosynthesis), Interleukin-7 Receptor alpha Subunit (immunology), Lymphocyte Activation (immunology), Lymphopenia (immunology), Neoplasms (therapy), Signal Transduction (immunology), T-Lymphocytes, Regulatory (immunology).
- MESH :
- chemical , biosynthesis : Interleukin-7, Interleukin-7 Receptor alpha Subunit.
- immunology : Immunologic Memory, Interleukin-7, Interleukin-7 Receptor alpha Subunit, Lymphocyte Activation, Lymphopenia, Signal Transduction, T-Lymphocytes, Regulatory.
- chemical , therapeutic use : Interleukin-7.
- therapy : Neoplasms.
- Humans.
Abstract
Interleukin-7 is a non-redundant growth, differentiation and survival factor for human T lymphocytes. Most circulating, mature T cells express the receptor for IL-7, but not all. Importantly, CD4 Tregs express greatly reduced levels of IL-7R compared to conventional CD4 T cells, presenting an opportunity to selectively target the latter cells with either more IL-7 to boost responses, or to block IL-7 signalling to limit responses. This article reviews what is known about regulation of IL-7R expression, and recent progress in therapeutic approaches related to IL-7 and its receptor.
DOI: 10.1016/j.cytogfr.2014.07.012
PubMed: 25130296
Affiliations:
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pubmed:25130296Le document en format XML
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Most circulating, mature T cells express the receptor for IL-7, but not all. Importantly, CD4 Tregs express greatly reduced levels of IL-7R compared to conventional CD4 T cells, presenting an opportunity to selectively target the latter cells with either more IL-7 to boost responses, or to block IL-7 signalling to limit responses. This article reviews what is known about regulation of IL-7R expression, and recent progress in therapeutic approaches related to IL-7 and its receptor.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25130296</PMID><DateCreated><Year>2014</Year><Month>09</Month><Day>30</Day></DateCreated><DateCompleted><Year>2015</Year><Month>06</Month><Day>08</Day></DateCompleted><DateRevised><Year>2014</Year><Month>09</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-0305</ISSN><JournalIssue CitedMedium="Internet"><Volume>25</Volume><Issue>4</Issue><PubDate><Year>2014</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Cytokine & growth factor reviews</Title><ISOAbbreviation>Cytokine Growth Factor Rev.</ISOAbbreviation></Journal><ArticleTitle>Exploiting differential expression of the IL-7 receptor on memory T cells to modulate immune responses.</ArticleTitle><Pagination><MedlinePgn>391-401</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.cytogfr.2014.07.012</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1359-6101(14)00074-4</ELocationID><Abstract><AbstractText>Interleukin-7 is a non-redundant growth, differentiation and survival factor for human T lymphocytes. Most circulating, mature T cells express the receptor for IL-7, but not all. Importantly, CD4 Tregs express greatly reduced levels of IL-7R compared to conventional CD4 T cells, presenting an opportunity to selectively target the latter cells with either more IL-7 to boost responses, or to block IL-7 signalling to limit responses. This article reviews what is known about regulation of IL-7R expression, and recent progress in therapeutic approaches related to IL-7 and its receptor.</AbstractText><CopyrightInformation>Copyright © 2014 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zaunders</LastName><ForeName>John J</ForeName><Initials>JJ</Initials><AffiliationInfo><Affiliation>Centre for Applied Medical Research, St. Vincent's Hospital, Australia; Kirby Institute, University of New South Wales, Sydney, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lévy</LastName><ForeName>Yves</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Inserm, U955, Equipe 16, Créteil, 94000, France; Université Paris Est, Faculté de médecine, Créteil, 94000, France; Vaccine Research Institute (VRI), Créteil, 94000, France; AP-HP, Hôpital H. Mondor-A. Chenevier, Service d'immunologie Clinique et maladies infectieuses, Créteil, 94000, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seddiki</LastName><ForeName>Nabila</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Inserm, U955, Equipe 16, Créteil, 94000, France; Université Paris Est, Faculté de médecine, Créteil, 94000, France; Vaccine Research Institute (VRI), Créteil, 94000, France. 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Zaunders</name></noRegion></country><country name="France"><noRegion><name sortKey="Levy, Yves" sort="Levy, Yves" uniqKey="Levy Y" first="Yves" last="Lévy">Yves Lévy</name></noRegion><name sortKey="Seddiki, Nabila" sort="Seddiki, Nabila" uniqKey="Seddiki N" first="Nabila" last="Seddiki">Nabila Seddiki</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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