A Phosphorylation-Induced Turn Defines the Alzheimer's Disease AT8 Antibody Epitope on the Tau Protein.
Identifieur interne : 003030 ( PubMed/Checkpoint ); précédent : 003029; suivant : 003031A Phosphorylation-Induced Turn Defines the Alzheimer's Disease AT8 Antibody Epitope on the Tau Protein.
Auteurs : Neha S. Gandhi ; Isabelle Landrieu ; Cillian Byrne [France] ; Predrag Kukic ; Laziza Amniai ; François-Xavier Cantrelle ; Jean-Michel Wieruszeski ; Ricardo L. Mancera ; Yves Jacquot [France] ; Guy Lippens [France]Source :
- Angewandte Chemie (International ed. in English) [ 1521-3773 ] ; 2015.
Descripteurs français
- KwdFr :
- Anticorps monoclonaux (immunologie), Cartographie épitopique, Humains, Maladie d'Alzheimer (immunologie), Maladie d'Alzheimer (métabolisme), Phosphorylation, Protéines tau (), Protéines tau (immunologie), Protéines tau (métabolisme), Résonance magnétique nucléaire biomoléculaire, Simulation de dynamique moléculaire, Épitopes (), Épitopes (immunologie).
- MESH :
English descriptors
- KwdEn :
- Alzheimer Disease (immunology), Alzheimer Disease (metabolism), Antibodies, Monoclonal (immunology), Epitope Mapping, Epitopes (chemistry), Epitopes (immunology), Humans, Molecular Dynamics Simulation, Nuclear Magnetic Resonance, Biomolecular, Phosphorylation, tau Proteins (chemistry), tau Proteins (immunology), tau Proteins (metabolism).
- MESH :
- chemical , chemistry : Epitopes, tau Proteins.
- chemical , immunology : Antibodies, Monoclonal, Epitopes, tau Proteins.
- immunology : Alzheimer Disease.
- metabolism : Alzheimer Disease, tau Proteins.
- Epitope Mapping, Humans, Molecular Dynamics Simulation, Nuclear Magnetic Resonance, Biomolecular, Phosphorylation.
Abstract
Post mortem biochemical staging of Alzheimer's disease is currently based on immunochemical analysis of brain slices with the AT8 antibody. The epitope of AT8 is described around the pSer202/pThr205 region of the hyperphosphorylated form of the neuronal protein tau. In this study, NMR spectroscopy was used to precisely map the AT8 epitope on phosphorylated tau, and derive its defining structural features by a combination of NMR analyses and molecular dynamics. A particular turn conformation is stabilized by a hydrogen bond of the phosphorylated Thr205 residue to the amide proton of Gly207, and is further stabilized by the two Arg residues opposing the pSer202/pThr205.
DOI: 10.1002/anie.201501898
PubMed: 25881502
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:25881502Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A Phosphorylation-Induced Turn Defines the Alzheimer's Disease AT8 Antibody Epitope on the Tau Protein.</title><author><name sortKey="Gandhi, Neha S" sort="Gandhi, Neha S" uniqKey="Gandhi N" first="Neha S" last="Gandhi">Neha S. Gandhi</name><affiliation><nlm:affiliation>School of Biomedical Sciences, CHIRI Biosciences, Curtin University, Perth (Australia).</nlm:affiliation><wicri:noCountry code="subField">Perth (Australia)</wicri:noCountry></affiliation></author><author><name sortKey="Landrieu, Isabelle" sort="Landrieu, Isabelle" uniqKey="Landrieu I" first="Isabelle" last="Landrieu">Isabelle Landrieu</name><affiliation><nlm:affiliation>CNRS UMR 8576, University of Lille 1 (France).</nlm:affiliation><wicri:noCountry code="subField">University of Lille 1 (France)</wicri:noCountry></affiliation></author><author><name sortKey="Byrne, Cillian" sort="Byrne, Cillian" uniqKey="Byrne C" first="Cillian" last="Byrne">Cillian Byrne</name><affiliation wicri:level="4"><nlm:affiliation>CNRS UMR 7203, Université Pierre et Marie Curie, Ecole Normale Supérieure, Paris (France).</nlm:affiliation><orgName type="university">Université Pierre-et-Marie-Curie</orgName><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Kukic, Predrag" sort="Kukic, Predrag" uniqKey="Kukic P" first="Predrag" last="Kukic">Predrag Kukic</name><affiliation><nlm:affiliation>Department of Chemistry, Cambridge University, Cambridge (UK).</nlm:affiliation><wicri:noCountry code="subField">Cambridge (UK)</wicri:noCountry></affiliation></author><author><name sortKey="Amniai, Laziza" sort="Amniai, Laziza" uniqKey="Amniai L" first="Laziza" last="Amniai">Laziza Amniai</name><affiliation><nlm:affiliation>CNRS UMR 8576, University of Lille 1 (France).</nlm:affiliation><wicri:noCountry code="subField">University of Lille 1 (France)</wicri:noCountry></affiliation></author><author><name sortKey="Cantrelle, Francois Xavier" sort="Cantrelle, Francois Xavier" uniqKey="Cantrelle F" first="François-Xavier" last="Cantrelle">François-Xavier Cantrelle</name><affiliation><nlm:affiliation>CNRS UMR 8576, University of Lille 1 (France).</nlm:affiliation><wicri:noCountry code="subField">University of Lille 1 (France)</wicri:noCountry></affiliation></author><author><name sortKey="Wieruszeski, Jean Michel" sort="Wieruszeski, Jean Michel" uniqKey="Wieruszeski J" first="Jean-Michel" last="Wieruszeski">Jean-Michel Wieruszeski</name><affiliation><nlm:affiliation>CNRS UMR 8576, University of Lille 1 (France).</nlm:affiliation><wicri:noCountry code="subField">University of Lille 1 (France)</wicri:noCountry></affiliation></author><author><name sortKey="Mancera, Ricardo L" sort="Mancera, Ricardo L" uniqKey="Mancera R" first="Ricardo L" last="Mancera">Ricardo L. Mancera</name><affiliation><nlm:affiliation>School of Biomedical Sciences, CHIRI Biosciences, Curtin University, Perth (Australia).</nlm:affiliation><wicri:noCountry code="subField">Perth (Australia)</wicri:noCountry></affiliation></author><author><name sortKey="Jacquot, Yves" sort="Jacquot, Yves" uniqKey="Jacquot Y" first="Yves" last="Jacquot">Yves Jacquot</name><affiliation wicri:level="4"><nlm:affiliation>CNRS UMR 7203, Université Pierre et Marie Curie, Ecole Normale Supérieure, Paris (France).</nlm:affiliation><orgName type="university">Université Pierre-et-Marie-Curie</orgName><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Lippens, Guy" sort="Lippens, Guy" uniqKey="Lippens G" first="Guy" last="Lippens">Guy Lippens</name><affiliation wicri:level="1"><nlm:affiliation>CNRS UMR 8576, University of Lille 1 (France). Guy.Lippens@univ-lille1.fr.</nlm:affiliation><country wicri:rule="url">France</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25881502</idno><idno type="pmid">25881502</idno><idno type="doi">10.1002/anie.201501898</idno><idno type="wicri:Area/PubMed/Corpus">002D27</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002D27</idno><idno type="wicri:Area/PubMed/Curation">002C52</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002C52</idno><idno type="wicri:Area/PubMed/Checkpoint">002C52</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002C52</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A Phosphorylation-Induced Turn Defines the Alzheimer's Disease AT8 Antibody Epitope on the Tau Protein.</title><author><name sortKey="Gandhi, Neha S" sort="Gandhi, Neha S" uniqKey="Gandhi N" first="Neha S" last="Gandhi">Neha S. Gandhi</name><affiliation><nlm:affiliation>School of Biomedical Sciences, CHIRI Biosciences, Curtin University, Perth (Australia).</nlm:affiliation><wicri:noCountry code="subField">Perth (Australia)</wicri:noCountry></affiliation></author><author><name sortKey="Landrieu, Isabelle" sort="Landrieu, Isabelle" uniqKey="Landrieu I" first="Isabelle" last="Landrieu">Isabelle Landrieu</name><affiliation><nlm:affiliation>CNRS UMR 8576, University of Lille 1 (France).</nlm:affiliation><wicri:noCountry code="subField">University of Lille 1 (France)</wicri:noCountry></affiliation></author><author><name sortKey="Byrne, Cillian" sort="Byrne, Cillian" uniqKey="Byrne C" first="Cillian" last="Byrne">Cillian Byrne</name><affiliation wicri:level="4"><nlm:affiliation>CNRS UMR 7203, Université Pierre et Marie Curie, Ecole Normale Supérieure, Paris (France).</nlm:affiliation><orgName type="university">Université Pierre-et-Marie-Curie</orgName><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Kukic, Predrag" sort="Kukic, Predrag" uniqKey="Kukic P" first="Predrag" last="Kukic">Predrag Kukic</name><affiliation><nlm:affiliation>Department of Chemistry, Cambridge University, Cambridge (UK).</nlm:affiliation><wicri:noCountry code="subField">Cambridge (UK)</wicri:noCountry></affiliation></author><author><name sortKey="Amniai, Laziza" sort="Amniai, Laziza" uniqKey="Amniai L" first="Laziza" last="Amniai">Laziza Amniai</name><affiliation><nlm:affiliation>CNRS UMR 8576, University of Lille 1 (France).</nlm:affiliation><wicri:noCountry code="subField">University of Lille 1 (France)</wicri:noCountry></affiliation></author><author><name sortKey="Cantrelle, Francois Xavier" sort="Cantrelle, Francois Xavier" uniqKey="Cantrelle F" first="François-Xavier" last="Cantrelle">François-Xavier Cantrelle</name><affiliation><nlm:affiliation>CNRS UMR 8576, University of Lille 1 (France).</nlm:affiliation><wicri:noCountry code="subField">University of Lille 1 (France)</wicri:noCountry></affiliation></author><author><name sortKey="Wieruszeski, Jean Michel" sort="Wieruszeski, Jean Michel" uniqKey="Wieruszeski J" first="Jean-Michel" last="Wieruszeski">Jean-Michel Wieruszeski</name><affiliation><nlm:affiliation>CNRS UMR 8576, University of Lille 1 (France).</nlm:affiliation><wicri:noCountry code="subField">University of Lille 1 (France)</wicri:noCountry></affiliation></author><author><name sortKey="Mancera, Ricardo L" sort="Mancera, Ricardo L" uniqKey="Mancera R" first="Ricardo L" last="Mancera">Ricardo L. Mancera</name><affiliation><nlm:affiliation>School of Biomedical Sciences, CHIRI Biosciences, Curtin University, Perth (Australia).</nlm:affiliation><wicri:noCountry code="subField">Perth (Australia)</wicri:noCountry></affiliation></author><author><name sortKey="Jacquot, Yves" sort="Jacquot, Yves" uniqKey="Jacquot Y" first="Yves" last="Jacquot">Yves Jacquot</name><affiliation wicri:level="4"><nlm:affiliation>CNRS UMR 7203, Université Pierre et Marie Curie, Ecole Normale Supérieure, Paris (France).</nlm:affiliation><orgName type="university">Université Pierre-et-Marie-Curie</orgName><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Lippens, Guy" sort="Lippens, Guy" uniqKey="Lippens G" first="Guy" last="Lippens">Guy Lippens</name><affiliation wicri:level="1"><nlm:affiliation>CNRS UMR 8576, University of Lille 1 (France). Guy.Lippens@univ-lille1.fr.</nlm:affiliation><country wicri:rule="url">France</country></affiliation></author></analytic><series><title level="j">Angewandte Chemie (International ed. in English)</title><idno type="eISSN">1521-3773</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer Disease (immunology)</term><term>Alzheimer Disease (metabolism)</term><term>Antibodies, Monoclonal (immunology)</term><term>Epitope Mapping</term><term>Epitopes (chemistry)</term><term>Epitopes (immunology)</term><term>Humans</term><term>Molecular Dynamics Simulation</term><term>Nuclear Magnetic Resonance, Biomolecular</term><term>Phosphorylation</term><term>tau Proteins (chemistry)</term><term>tau Proteins (immunology)</term><term>tau Proteins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Anticorps monoclonaux (immunologie)</term><term>Cartographie épitopique</term><term>Humains</term><term>Maladie d'Alzheimer (immunologie)</term><term>Maladie d'Alzheimer (métabolisme)</term><term>Phosphorylation</term><term>Protéines tau ()</term><term>Protéines tau (immunologie)</term><term>Protéines tau (métabolisme)</term><term>Résonance magnétique nucléaire biomoléculaire</term><term>Simulation de dynamique moléculaire</term><term>Épitopes ()</term><term>Épitopes (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Epitopes</term><term>tau Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Epitopes</term><term>tau Proteins</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps monoclonaux</term><term>Maladie d'Alzheimer</term><term>Protéines tau</term><term>Épitopes</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Alzheimer Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Alzheimer Disease</term><term>tau Proteins</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Maladie d'Alzheimer</term><term>Protéines tau</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Epitope Mapping</term><term>Humans</term><term>Molecular Dynamics Simulation</term><term>Nuclear Magnetic Resonance, Biomolecular</term><term>Phosphorylation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Cartographie épitopique</term><term>Humains</term><term>Phosphorylation</term><term>Protéines tau</term><term>Résonance magnétique nucléaire biomoléculaire</term><term>Simulation de dynamique moléculaire</term><term>Épitopes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Post mortem biochemical staging of Alzheimer's disease is currently based on immunochemical analysis of brain slices with the AT8 antibody. The epitope of AT8 is described around the pSer202/pThr205 region of the hyperphosphorylated form of the neuronal protein tau. In this study, NMR spectroscopy was used to precisely map the AT8 epitope on phosphorylated tau, and derive its defining structural features by a combination of NMR analyses and molecular dynamics. A particular turn conformation is stabilized by a hydrogen bond of the phosphorylated Thr205 residue to the amide proton of Gly207, and is further stabilized by the two Arg residues opposing the pSer202/pThr205.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25881502</PMID><DateCreated><Year>2015</Year><Month>05</Month><Day>27</Day></DateCreated><DateCompleted><Year>2016</Year><Month>02</Month><Day>11</Day></DateCompleted><DateRevised><Year>2015</Year><Month>05</Month><Day>27</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1521-3773</ISSN><JournalIssue CitedMedium="Internet"><Volume>54</Volume><Issue>23</Issue><PubDate><Year>2015</Year><Month>Jun</Month><Day>01</Day></PubDate></JournalIssue><Title>Angewandte Chemie (International ed. in English)</Title><ISOAbbreviation>Angew. Chem. Int. Ed. Engl.</ISOAbbreviation></Journal><ArticleTitle>A Phosphorylation-Induced Turn Defines the Alzheimer's Disease AT8 Antibody Epitope on the Tau Protein.</ArticleTitle><Pagination><MedlinePgn>6819-23</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/anie.201501898</ELocationID><Abstract><AbstractText>Post mortem biochemical staging of Alzheimer's disease is currently based on immunochemical analysis of brain slices with the AT8 antibody. The epitope of AT8 is described around the pSer202/pThr205 region of the hyperphosphorylated form of the neuronal protein tau. In this study, NMR spectroscopy was used to precisely map the AT8 epitope on phosphorylated tau, and derive its defining structural features by a combination of NMR analyses and molecular dynamics. A particular turn conformation is stabilized by a hydrogen bond of the phosphorylated Thr205 residue to the amide proton of Gly207, and is further stabilized by the two Arg residues opposing the pSer202/pThr205.</AbstractText><CopyrightInformation>© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gandhi</LastName><ForeName>Neha S</ForeName><Initials>NS</Initials><AffiliationInfo><Affiliation>School of Biomedical Sciences, CHIRI Biosciences, Curtin University, Perth (Australia).</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Landrieu</LastName><ForeName>Isabelle</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>CNRS UMR 8576, University of Lille 1 (France).</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Byrne</LastName><ForeName>Cillian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>CNRS UMR 7203, Université Pierre et Marie Curie, Ecole Normale Supérieure, Paris (France).</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institut Baulieu, Kremlin-Bicêtre (France).</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kukic</LastName><ForeName>Predrag</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Chemistry, Cambridge University, Cambridge (UK).</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Amniai</LastName><ForeName>Laziza</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>CNRS UMR 8576, University of Lille 1 (France).</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cantrelle</LastName><ForeName>François-Xavier</ForeName><Initials>FX</Initials><AffiliationInfo><Affiliation>CNRS UMR 8576, University of Lille 1 (France).</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wieruszeski</LastName><ForeName>Jean-Michel</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>CNRS UMR 8576, University of Lille 1 (France).</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mancera</LastName><ForeName>Ricardo L</ForeName><Initials>RL</Initials><AffiliationInfo><Affiliation>School of Biomedical Sciences, CHIRI Biosciences, Curtin University, Perth (Australia).</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jacquot</LastName><ForeName>Yves</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>CNRS UMR 7203, Université Pierre et Marie Curie, Ecole Normale Supérieure, Paris (France).</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lippens</LastName><ForeName>Guy</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>CNRS UMR 8576, University of Lille 1 (France). Guy.Lippens@univ-lille1.fr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>04</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Angew Chem Int Ed Engl</MedlineTA><NlmUniqueID>0370543</NlmUniqueID><ISSNLinking>1433-7851</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000911">Antibodies, Monoclonal</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000939">Epitopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016875">tau Proteins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000544" MajorTopicYN="N">Alzheimer Disease</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000911" MajorTopicYN="N">Antibodies, Monoclonal</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018604" MajorTopicYN="Y">Epitope Mapping</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000939" MajorTopicYN="N">Epitopes</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D056004" MajorTopicYN="N">Molecular Dynamics Simulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019906" MajorTopicYN="N">Nuclear Magnetic Resonance, Biomolecular</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010766" MajorTopicYN="N">Phosphorylation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016875" MajorTopicYN="N">tau Proteins</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">AT8 antibody</Keyword><Keyword MajorTopicYN="N">Alzheimer’s disease</Keyword><Keyword MajorTopicYN="N">epitope mapping</Keyword><Keyword MajorTopicYN="N">phosphorylation</Keyword><Keyword MajorTopicYN="N">tau protein</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>03</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>4</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>4</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>2</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25881502</ArticleId><ArticleId IdType="doi">10.1002/anie.201501898</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement><orgName><li>Université Pierre-et-Marie-Curie</li></orgName></list><tree><noCountry><name sortKey="Amniai, Laziza" sort="Amniai, Laziza" uniqKey="Amniai L" first="Laziza" last="Amniai">Laziza Amniai</name><name sortKey="Cantrelle, Francois Xavier" sort="Cantrelle, Francois Xavier" uniqKey="Cantrelle F" first="François-Xavier" last="Cantrelle">François-Xavier Cantrelle</name><name sortKey="Gandhi, Neha S" sort="Gandhi, Neha S" uniqKey="Gandhi N" first="Neha S" last="Gandhi">Neha S. Gandhi</name><name sortKey="Kukic, Predrag" sort="Kukic, Predrag" uniqKey="Kukic P" first="Predrag" last="Kukic">Predrag Kukic</name><name sortKey="Landrieu, Isabelle" sort="Landrieu, Isabelle" uniqKey="Landrieu I" first="Isabelle" last="Landrieu">Isabelle Landrieu</name><name sortKey="Mancera, Ricardo L" sort="Mancera, Ricardo L" uniqKey="Mancera R" first="Ricardo L" last="Mancera">Ricardo L. Mancera</name><name sortKey="Wieruszeski, Jean Michel" sort="Wieruszeski, Jean Michel" uniqKey="Wieruszeski J" first="Jean-Michel" last="Wieruszeski">Jean-Michel Wieruszeski</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Byrne, Cillian" sort="Byrne, Cillian" uniqKey="Byrne C" first="Cillian" last="Byrne">Cillian Byrne</name></region><name sortKey="Jacquot, Yves" sort="Jacquot, Yves" uniqKey="Jacquot Y" first="Yves" last="Jacquot">Yves Jacquot</name><name sortKey="Lippens, Guy" sort="Lippens, Guy" uniqKey="Lippens G" first="Guy" last="Lippens">Guy Lippens</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003030 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 003030 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= PubMed
|étape= Checkpoint
|type= RBID
|clé= pubmed:25881502
|texte= A Phosphorylation-Induced Turn Defines the Alzheimer's Disease AT8 Antibody Epitope on the Tau Protein.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:25881502" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |