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Approaches to catheter ablation for persistent atrial fibrillation.

Identifieur interne : 002F35 ( PubMed/Checkpoint ); précédent : 002F34; suivant : 002F36

Approaches to catheter ablation for persistent atrial fibrillation.

Auteurs : Atul Verma [Canada] ; Chen-Yang Jiang ; Timothy R. Betts ; Jian Chen ; Isabel Deisenhofer ; Roberto Mantovan ; Laurent Macle ; Carlos A. Morillo ; Wilhelm Haverkamp ; Rukshen Weerasooriya ; Jean-Paul Albenque ; Stefano Nardi ; Endrj Menardi ; Paul Novak ; Prashanthan Sanders

Source :

RBID : pubmed:25946280

Descripteurs français

English descriptors

Abstract

Catheter ablation is less successful for persistent atrial fibrillation than for paroxysmal atrial fibrillation. Guidelines suggest that adjuvant substrate modification in addition to pulmonary-vein isolation is required in persistent atrial fibrillation.

DOI: 10.1056/NEJMoa1408288
PubMed: 25946280


Affiliations:


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pubmed:25946280

Le document en format XML

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<term>Disease-Free Survival</term>
<term>Electrocardiography</term>
<term>Female</term>
<term>Heart Atria (surgery)</term>
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<term>Ablation par cathéter ()</term>
<term>Ablation par cathéter (effets indésirables)</term>
<term>Adulte d'âge moyen</term>
<term>Atrium du coeur ()</term>
<term>Durée opératoire</term>
<term>Débit systolique</term>
<term>Estimation de Kaplan-Meier</term>
<term>Femelle</term>
<term>Fibrillation auriculaire ()</term>
<term>Humains</term>
<term>Modèles de hasards proportionnels</term>
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<term>Catheter Ablation</term>
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<term>Ablation par cathéter</term>
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<keywords scheme="MESH" qualifier="methods" xml:lang="en">
<term>Catheter Ablation</term>
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<keywords scheme="MESH" qualifier="surgery" xml:lang="en">
<term>Atrial Fibrillation</term>
<term>Heart Atria</term>
<term>Mitral Valve</term>
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<term>Disease-Free Survival</term>
<term>Electrocardiography</term>
<term>Female</term>
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<term>Kaplan-Meier Estimate</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Operative Time</term>
<term>Proportional Hazards Models</term>
<term>Pulmonary Veins</term>
<term>Recurrence</term>
<term>Secondary Prevention</term>
<term>Stroke Volume</term>
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<term>Ablation par cathéter</term>
<term>Adulte d'âge moyen</term>
<term>Atrium du coeur</term>
<term>Durée opératoire</term>
<term>Débit systolique</term>
<term>Estimation de Kaplan-Meier</term>
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<term>Fibrillation auriculaire</term>
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<term>Modèles de hasards proportionnels</term>
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<front>
<div type="abstract" xml:lang="en">Catheter ablation is less successful for persistent atrial fibrillation than for paroxysmal atrial fibrillation. Guidelines suggest that adjuvant substrate modification in addition to pulmonary-vein isolation is required in persistent atrial fibrillation.</div>
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<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Catheter ablation is less successful for persistent atrial fibrillation than for paroxysmal atrial fibrillation. Guidelines suggest that adjuvant substrate modification in addition to pulmonary-vein isolation is required in persistent atrial fibrillation.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We randomly assigned 589 patients with persistent atrial fibrillation in a 1:4:4 ratio to ablation with pulmonary-vein isolation alone (67 patients), pulmonary-vein isolation plus ablation of electrograms showing complex fractionated activity (263 patients), or pulmonary-vein isolation plus additional linear ablation across the left atrial roof and mitral valve isthmus (259 patients). The duration of follow-up was 18 months. The primary end point was freedom from any documented recurrence of atrial fibrillation lasting longer than 30 seconds after a single ablation procedure.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Procedure time was significantly shorter for pulmonary-vein isolation alone than for the other two procedures (P<0.001). After 18 months, 59% of patients assigned to pulmonary-vein isolation alone were free from recurrent atrial fibrillation, as compared with 49% of patients assigned to pulmonary-vein isolation plus complex electrogram ablation and 46% of patients assigned to pulmonary-vein isolation plus linear ablation (P=0.15). There were also no significant differences among the three groups for the secondary end points, including freedom from atrial fibrillation after two ablation procedures and freedom from any atrial arrhythmia. Complications included tamponade (three patients), stroke or transient ischemic attack (three patients), and atrioesophageal fistula (one patient).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Among patients with persistent atrial fibrillation, we found no reduction in the rate of recurrent atrial fibrillation when either linear ablation or ablation of complex fractionated electrograms was performed in addition to pulmonary-vein isolation. (Funded by St. Jude Medical; ClinicalTrials.gov number, NCT01203748.).</AbstractText>
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<Affiliation>From Southlake Regional Health Centre, Newmarket, ON (A.V.), Montreal Heart Institute, Montreal (L.M.), McMaster University, Hamilton, ON (C.A.M.), and Royal Jubilee Hospital, Victoria, BC (P.N.) - all in Canada; Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China (C.J.); John Radcliffe Hospital, Oxford, United Kingdom (T.R.B.); Haukeland University Hospital, Bergen, Norway (J.C.); the German Heart Center, Munich (I.D.), and Charité Campus Virchow-Klinikum, Berlin (W.H.) - both in Germany; Ospedale M. Bufalini, Cesena (R.M.), Presidio Ospedaliero Pineta Grande, Castel Volturno (S.N.), and Ospedale Santa Croce e Carle, Cuneo (E.M.) - all in Italy; Hollywood Private Hospital, Perth, WA (R.W.), and the University of Adelaide and Royal Adelaide Hospital, Adelaide, SA (P.S.) - all in Australia; and Clinique Pasteur Toulouse, Toulouse, France (J.-P.A.).</Affiliation>
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<DescriptorName UI="D018572" MajorTopicYN="N">Disease-Free Survival</DescriptorName>
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