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Candida infective endocarditis: an observational cohort study with a focus on therapy.

Identifieur interne : 002E66 ( PubMed/Checkpoint ); précédent : 002E65; suivant : 002E67

Candida infective endocarditis: an observational cohort study with a focus on therapy.

Auteurs : Christopher J. Arnold [États-Unis] ; Melissa Johnson [États-Unis] ; Arnold S. Bayer [États-Unis] ; Suzanne Bradley [États-Unis] ; Efthymia Giannitsioti [Grèce] ; José M. Mir [Espagne] ; Pilar Tornos [Espagne] ; Pierre Tattevin [France] ; Jacob Strahilevitz [Israël] ; Denis Spelman [Australie] ; Eugene Athan [Australie] ; Francisco Nacinovich [Argentine] ; Claudio Q. Fortes [Brésil] ; Cristiane Lamas [Brésil] ; Bruno Barsic [Croatie] ; Nuria Fernández-Hidalgo [Espagne] ; Patricia Mu Oz [Espagne] ; Vivian H. Chu [États-Unis]

Source :

Antimicrobial agents and chemotherapy [ 1098-6596 ] ; 2015.

RBID : pubmed:25645855

Descripteurs français

KwdFr :
- Adulte, Adulte d'âge moyen, Amphotéricine B (usage thérapeutique), Antifongiques (administration et posologie), Antifongiques (usage thérapeutique), Candidose (microbiologie), Candidose (mortalité), Candidose (traitement médicamenteux), Endocardite (microbiologie), Endocardite (mortalité), Endocardite (traitement médicamenteux), Facteurs de l'âge, Facteurs de risque, Femelle, Humains, Infection croisée (mortalité), Infection croisée (traitement médicamenteux), Mortalité hospitalière, Mâle, Sujet âgé, Échinocandines (usage thérapeutique), Études de cohortes, Études prospectives.
MESH :
- administration et posologie : Antifongiques.
- microbiologie : Candidose, Endocardite.
- mortalité : Candidose, Endocardite, Infection croisée.
- traitement médicamenteux : Candidose, Endocardite, Infection croisée.
- usage thérapeutique : Amphotéricine B, Antifongiques, Échinocandines.
- Adulte, Adulte d'âge moyen, Facteurs de l'âge, Facteurs de risque, Femelle, Humains, Mortalité hospitalière, Mâle, Sujet âgé, Études de cohortes, Études prospectives.

English descriptors

KwdEn :
- Adult, Age Factors, Aged, Amphotericin B (therapeutic use), Antifungal Agents (administration & dosage), Antifungal Agents (therapeutic use), Candidiasis (drug therapy), Candidiasis (microbiology), Candidiasis (mortality), Cohort Studies, Cross Infection (drug therapy), Cross Infection (mortality), Echinocandins (therapeutic use), Endocarditis (drug therapy), Endocarditis (microbiology), Endocarditis (mortality), Female, Hospital Mortality, Humans, Male, Middle Aged, Prospective Studies, Risk Factors.
MESH :
- chemical , administration & dosage : Antifungal Agents.
- chemical , therapeutic use : Amphotericin B, Antifungal Agents, Echinocandins.
- drug therapy : Candidiasis, Cross Infection, Endocarditis.
- microbiology : Candidiasis, Endocarditis.
- mortality : Candidiasis, Cross Infection, Endocarditis.
- Adult, Age Factors, Aged, Cohort Studies, Female, Hospital Mortality, Humans, Male, Middle Aged, Prospective Studies, Risk Factors.

Abstract

Candida infective endocarditis is a rare disease with a high mortality rate. Our understanding of this infection is derived from case series, case reports, and small prospective cohorts. The purpose of this study was to evaluate the clinical features and use of different antifungal treatment regimens for Candida infective endocarditis. This prospective cohort study was based on 70 cases of Candida infective endocarditis from the International Collaboration on Endocarditis (ICE)-Prospective Cohort Study and ICE-Plus databases collected between 2000 and 2010. The majority of infections were acquired nosocomially (67%). Congestive heart failure (24%), prosthetic heart valve (46%), and previous infective endocarditis (26%) were common comorbidities. Overall mortality was high, with 36% mortality in the hospital and 59% at 1 year. On univariate analysis, older age, heart failure at baseline, persistent candidemia, nosocomial acquisition, heart failure as a complication, and intracardiac abscess were associated with higher mortality. Mortality was not affected by use of surgical therapy or choice of antifungal agent. A subgroup analysis was performed on 33 patients for whom specific antifungal therapy information was available. In this subgroup, 11 patients received amphotericin B-based therapy and 14 received echinocandin-based therapy. Despite a higher percentage of older patients and nosocomial infection in the echinocandin group, mortality rates were similar between the two groups. In conclusion, Candida infective endocarditis is associated with a high mortality rate that was not impacted by choice of antifungal therapy or by adjunctive surgical intervention. Additionally, echinocandin therapy was as effective as amphotericin B-based therapy in the small subgroup analysis.

DOI: 10.1128/AAC.04867-14
PubMed: 25645855

Affiliations:

Argentine, Australie, Brésil, Croatie, Espagne, France, Grèce, Israël, États-Unis
Attique (région), Californie, Caroline du Nord, Catalogne, Communauté de Madrid, Michigan, Région Bretagne, Victoria (État), État de Rio de Janeiro
Athènes, Barcelone, Madrid, Melbourne, Rennes, Rio de Janeiro

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pubmed:25645855

Le document en format XML

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<author><name sortKey="Athan, Eugene" sort="Athan, Eugene" uniqKey="Athan E" first="Eugene" last="Athan">Eugene Athan</name>
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<author><name sortKey="Mu Oz, Patricia" sort="Mu Oz, Patricia" uniqKey="Mu Oz P" first="Patricia" last="Mu Oz">Patricia Mu Oz</name>
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<author><name sortKey="Chu, Vivian H" sort="Chu, Vivian H" uniqKey="Chu V" first="Vivian H" last="Chu">Vivian H. Chu</name>
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<author><name sortKey="Bayer, Arnold S" sort="Bayer, Arnold S" uniqKey="Bayer A" first="Arnold S" last="Bayer">Arnold S. Bayer</name>
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<author><name sortKey="Bradley, Suzanne" sort="Bradley, Suzanne" uniqKey="Bradley S" first="Suzanne" last="Bradley">Suzanne Bradley</name>
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<author><name sortKey="Mir, Jose M" sort="Mir, Jose M" uniqKey="Mir J" first="José M" last="Mir">José M. Mir</name>
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<author><name sortKey="Tattevin, Pierre" sort="Tattevin, Pierre" uniqKey="Tattevin P" first="Pierre" last="Tattevin">Pierre Tattevin</name>
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<author><name sortKey="Strahilevitz, Jacob" sort="Strahilevitz, Jacob" uniqKey="Strahilevitz J" first="Jacob" last="Strahilevitz">Jacob Strahilevitz</name>
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<author><name sortKey="Spelman, Denis" sort="Spelman, Denis" uniqKey="Spelman D" first="Denis" last="Spelman">Denis Spelman</name>
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<author><name sortKey="Athan, Eugene" sort="Athan, Eugene" uniqKey="Athan E" first="Eugene" last="Athan">Eugene Athan</name>
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<author><name sortKey="Nacinovich, Francisco" sort="Nacinovich, Francisco" uniqKey="Nacinovich F" first="Francisco" last="Nacinovich">Francisco Nacinovich</name>
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<country xml:lang="fr">Argentine</country>
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<author><name sortKey="Fortes, Claudio Q" sort="Fortes, Claudio Q" uniqKey="Fortes C" first="Claudio Q" last="Fortes">Claudio Q. Fortes</name>
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<author><name sortKey="Lamas, Cristiane" sort="Lamas, Cristiane" uniqKey="Lamas C" first="Cristiane" last="Lamas">Cristiane Lamas</name>
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<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Instituto Nacional de Cardiologia and Unigranrio, Rio de Janeiro</wicri:regionArea>
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</placeName>
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<author><name sortKey="Barsic, Bruno" sort="Barsic, Bruno" uniqKey="Barsic B" first="Bruno" last="Barsic">Bruno Barsic</name>
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<country xml:lang="fr">Croatie</country>
<wicri:regionArea>University Hospital for Infectious Diseases, Zagreb</wicri:regionArea>
<wicri:noRegion>Zagreb</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fernandez Hidalgo, Nuria" sort="Fernandez Hidalgo, Nuria" uniqKey="Fernandez Hidalgo N" first="Nuria" last="Fernández-Hidalgo">Nuria Fernández-Hidalgo</name>
<affiliation wicri:level="3"><nlm:affiliation>Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mu Oz, Patricia" sort="Mu Oz, Patricia" uniqKey="Mu Oz P" first="Patricia" last="Mu Oz">Patricia Mu Oz</name>
<affiliation wicri:level="3"><nlm:affiliation>Hospital General Universitario Gregorio Marañón, Madrid, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
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<author><name sortKey="Chu, Vivian H" sort="Chu, Vivian H" uniqKey="Chu V" first="Vivian H" last="Chu">Vivian H. Chu</name>
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<series><title level="j">Antimicrobial agents and chemotherapy</title>
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<term>Antifungal Agents (therapeutic use)</term>
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<front><div type="abstract" xml:lang="en">Candida infective endocarditis is a rare disease with a high mortality rate. Our understanding of this infection is derived from case series, case reports, and small prospective cohorts. The purpose of this study was to evaluate the clinical features and use of different antifungal treatment regimens for Candida infective endocarditis. This prospective cohort study was based on 70 cases of Candida infective endocarditis from the International Collaboration on Endocarditis (ICE)-Prospective Cohort Study and ICE-Plus databases collected between 2000 and 2010. The majority of infections were acquired nosocomially (67%). Congestive heart failure (24%), prosthetic heart valve (46%), and previous infective endocarditis (26%) were common comorbidities. Overall mortality was high, with 36% mortality in the hospital and 59% at 1 year. On univariate analysis, older age, heart failure at baseline, persistent candidemia, nosocomial acquisition, heart failure as a complication, and intracardiac abscess were associated with higher mortality. Mortality was not affected by use of surgical therapy or choice of antifungal agent. A subgroup analysis was performed on 33 patients for whom specific antifungal therapy information was available. In this subgroup, 11 patients received amphotericin B-based therapy and 14 received echinocandin-based therapy. Despite a higher percentage of older patients and nosocomial infection in the echinocandin group, mortality rates were similar between the two groups. In conclusion, Candida infective endocarditis is associated with a high mortality rate that was not impacted by choice of antifungal therapy or by adjunctive surgical intervention. Additionally, echinocandin therapy was as effective as amphotericin B-based therapy in the small subgroup analysis.</div>
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<DateCreated><Year>2015</Year>
<Month>03</Month>
<Day>12</Day>
</DateCreated>
<DateCompleted><Year>2015</Year>
<Month>12</Month>
<Day>08</Day>
</DateCompleted>
<DateRevised><Year>2015</Year>
<Month>10</Month>
<Day>01</Day>
</DateRevised>
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<JournalIssue CitedMedium="Internet"><Volume>59</Volume>
<Issue>4</Issue>
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<Month>Apr</Month>
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<Title>Antimicrobial agents and chemotherapy</Title>
<ISOAbbreviation>Antimicrob. Agents Chemother.</ISOAbbreviation>
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<ArticleTitle>Candida infective endocarditis: an observational cohort study with a focus on therapy.</ArticleTitle>
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<Abstract><AbstractText>Candida infective endocarditis is a rare disease with a high mortality rate. Our understanding of this infection is derived from case series, case reports, and small prospective cohorts. The purpose of this study was to evaluate the clinical features and use of different antifungal treatment regimens for Candida infective endocarditis. This prospective cohort study was based on 70 cases of Candida infective endocarditis from the International Collaboration on Endocarditis (ICE)-Prospective Cohort Study and ICE-Plus databases collected between 2000 and 2010. The majority of infections were acquired nosocomially (67%). Congestive heart failure (24%), prosthetic heart valve (46%), and previous infective endocarditis (26%) were common comorbidities. Overall mortality was high, with 36% mortality in the hospital and 59% at 1 year. On univariate analysis, older age, heart failure at baseline, persistent candidemia, nosocomial acquisition, heart failure as a complication, and intracardiac abscess were associated with higher mortality. Mortality was not affected by use of surgical therapy or choice of antifungal agent. A subgroup analysis was performed on 33 patients for whom specific antifungal therapy information was available. In this subgroup, 11 patients received amphotericin B-based therapy and 14 received echinocandin-based therapy. Despite a higher percentage of older patients and nosocomial infection in the echinocandin group, mortality rates were similar between the two groups. In conclusion, Candida infective endocarditis is associated with a high mortality rate that was not impacted by choice of antifungal therapy or by adjunctive surgical intervention. Additionally, echinocandin therapy was as effective as amphotericin B-based therapy in the small subgroup analysis.</AbstractText>
<CopyrightInformation>Copyright © 2015, American Society for Microbiology. All Rights Reserved.</CopyrightInformation>
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<Initials>J</Initials>
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<ForeName>Denis</ForeName>
<Initials>D</Initials>
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</AffiliationInfo>
</Author>
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<ForeName>Eugene</ForeName>
<Initials>E</Initials>
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<ForeName>Francisco</ForeName>
<Initials>F</Initials>
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<ForeName>Claudio Q</ForeName>
<Initials>CQ</Initials>
<AffiliationInfo><Affiliation>Hospital Universitario Clementino Fraga Filho/UFRJ, Rio de Janeiro, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
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<ForeName>Cristiane</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Instituto Nacional de Cardiologia and Unigranrio, Rio de Janeiro, Brazil.</Affiliation>
</AffiliationInfo>
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<ForeName>Bruno</ForeName>
<Initials>B</Initials>
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</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fernández-Hidalgo</LastName>
<ForeName>Nuria</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Muñoz</LastName>
<ForeName>Patricia</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Hospital General Universitario Gregorio Marañón, Madrid, Spain.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Chu</LastName>
<ForeName>Vivian H</ForeName>
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<AffiliationInfo><Affiliation>Duke University Medical Center, Durham, North Carolina, USA.</Affiliation>
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<name sortKey="Bradley, Suzanne" sort="Bradley, Suzanne" uniqKey="Bradley S" first="Suzanne" last="Bradley">Suzanne Bradley</name>
<name sortKey="Chu, Vivian H" sort="Chu, Vivian H" uniqKey="Chu V" first="Vivian H" last="Chu">Vivian H. Chu</name>
<name sortKey="Johnson, Melissa" sort="Johnson, Melissa" uniqKey="Johnson M" first="Melissa" last="Johnson">Melissa Johnson</name>
</country>
<country name="Grèce"><region name="Attique (région)"><name sortKey="Giannitsioti, Efthymia" sort="Giannitsioti, Efthymia" uniqKey="Giannitsioti E" first="Efthymia" last="Giannitsioti">Efthymia Giannitsioti</name>
</region>
</country>
<country name="Espagne"><region name="Catalogne"><name sortKey="Mir, Jose M" sort="Mir, Jose M" uniqKey="Mir J" first="José M" last="Mir">José M. Mir</name>
</region>
<name sortKey="Fernandez Hidalgo, Nuria" sort="Fernandez Hidalgo, Nuria" uniqKey="Fernandez Hidalgo N" first="Nuria" last="Fernández-Hidalgo">Nuria Fernández-Hidalgo</name>
<name sortKey="Mu Oz, Patricia" sort="Mu Oz, Patricia" uniqKey="Mu Oz P" first="Patricia" last="Mu Oz">Patricia Mu Oz</name>
<name sortKey="Tornos, Pilar" sort="Tornos, Pilar" uniqKey="Tornos P" first="Pilar" last="Tornos">Pilar Tornos</name>
</country>
<country name="France"><region name="Région Bretagne"><name sortKey="Tattevin, Pierre" sort="Tattevin, Pierre" uniqKey="Tattevin P" first="Pierre" last="Tattevin">Pierre Tattevin</name>
</region>
</country>
<country name="Israël"><noRegion><name sortKey="Strahilevitz, Jacob" sort="Strahilevitz, Jacob" uniqKey="Strahilevitz J" first="Jacob" last="Strahilevitz">Jacob Strahilevitz</name>
</noRegion>
</country>
<country name="Australie"><region name="Victoria (État)"><name sortKey="Spelman, Denis" sort="Spelman, Denis" uniqKey="Spelman D" first="Denis" last="Spelman">Denis Spelman</name>
</region>
<name sortKey="Athan, Eugene" sort="Athan, Eugene" uniqKey="Athan E" first="Eugene" last="Athan">Eugene Athan</name>
</country>
<country name="Argentine"><noRegion><name sortKey="Nacinovich, Francisco" sort="Nacinovich, Francisco" uniqKey="Nacinovich F" first="Francisco" last="Nacinovich">Francisco Nacinovich</name>
</noRegion>
</country>
<country name="Brésil"><region name="État de Rio de Janeiro"><name sortKey="Fortes, Claudio Q" sort="Fortes, Claudio Q" uniqKey="Fortes C" first="Claudio Q" last="Fortes">Claudio Q. Fortes</name>
</region>
<name sortKey="Lamas, Cristiane" sort="Lamas, Cristiane" uniqKey="Lamas C" first="Cristiane" last="Lamas">Cristiane Lamas</name>
</country>
<country name="Croatie"><noRegion><name sortKey="Barsic, Bruno" sort="Barsic, Bruno" uniqKey="Barsic B" first="Bruno" last="Barsic">Bruno Barsic</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Checkpoint

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002E66 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 002E66 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    PubMed
   |étape=   Checkpoint
   |type=    RBID
   |clé=     pubmed:25645855
   |texte=   Candida infective endocarditis: an observational cohort study with a focus on therapy.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i   -Sk "pubmed:25645855" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd   \
       | NlmPubMed2Wicri -a AustralieFrV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les relations entre la France et l'Australie

Candida infective endocarditis: an observational cohort study with a focus on therapy.

Candida infective endocarditis: an observational cohort study with a focus on therapy.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki