AustralieFrV1, PubMed, Checkpoint, bibRecord, 002E09

Colchicine Acutely Suppresses Local Cardiac Production of Inflammatory Cytokines in Patients With an Acute Coronary Syndrome.

Identifieur interne : 002E09 ( PubMed/Checkpoint ); précédent : 002E08; suivant : 002E10

Colchicine Acutely Suppresses Local Cardiac Production of Inflammatory Cytokines in Patients With an Acute Coronary Syndrome.

Auteurs : Gonzalo J. Martínez [Australie] ; Stacy Robertson [Australie] ; Jennifer Barraclough ; Qiong Xia [Australie] ; Ziad Mallat [Royaume-Uni] ; Christina Bursill [Australie] ; David S. Celermajer [Australie] ; Sanjay Patel [Australie]

Source :

Journal of the American Heart Association [ 2047-9980 ] ; 2015.

RBID : pubmed:26304941

Descripteurs français

KwdFr :
- Adulte d'âge moyen, Anti-inflammatoires (usage thérapeutique), Colchicine (usage thérapeutique), Cytokines (sang), Facteurs temps, Femelle, Humains, Interleukine-1 bêta (sang), Interleukine-18 (sang), Interleukine-6 (sang), Maladie des artères coronaires (diagnostic), Maladie des artères coronaires (immunologie), Maladie des artères coronaires (sang), Maladie des artères coronaires (traitement médicamenteux), Marqueurs biologiques (sang), Myocarde (immunologie), Myocarde (métabolisme), Mâle, Médiateurs de l'inflammation (sang), Nouvelle-Galles du Sud, Régulation négative, Résultat thérapeutique, Sinus coronaire, Sujet âgé, Syndrome coronarien aigu (diagnostic), Syndrome coronarien aigu (immunologie), Syndrome coronarien aigu (sang), Syndrome coronarien aigu (traitement médicamenteux), Test ELISA.
MESH :
- diagnostic : Maladie des artères coronaires, Syndrome coronarien aigu.
- immunologie : Maladie des artères coronaires, Myocarde, Syndrome coronarien aigu.
- métabolisme : Myocarde.
- sang : Cytokines, Interleukine-1 bêta, Interleukine-18, Interleukine-6, Maladie des artères coronaires, Marqueurs biologiques, Médiateurs de l'inflammation, Syndrome coronarien aigu.
- traitement médicamenteux : Maladie des artères coronaires, Syndrome coronarien aigu.
- usage thérapeutique : Anti-inflammatoires, Colchicine.
- Adulte d'âge moyen, Facteurs temps, Femelle, Humains, Mâle, Nouvelle-Galles du Sud, Régulation négative, Résultat thérapeutique, Sinus coronaire, Sujet âgé, Test ELISA.

English descriptors

KwdEn :
- Acute Coronary Syndrome (blood), Acute Coronary Syndrome (diagnosis), Acute Coronary Syndrome (drug therapy), Acute Coronary Syndrome (immunology), Aged, Anti-Inflammatory Agents (therapeutic use), Biomarkers (blood), Colchicine (therapeutic use), Coronary Artery Disease (blood), Coronary Artery Disease (diagnosis), Coronary Artery Disease (drug therapy), Coronary Artery Disease (immunology), Coronary Sinus, Cytokines (blood), Down-Regulation, Enzyme-Linked Immunosorbent Assay, Female, Humans, Inflammation Mediators (blood), Interleukin-18 (blood), Interleukin-1beta (blood), Interleukin-6 (blood), Male, Middle Aged, Myocardium (immunology), Myocardium (metabolism), New South Wales, Time Factors, Treatment Outcome.
MESH :
- chemical , blood : Biomarkers, Cytokines, Inflammation Mediators, Interleukin-18, Interleukin-1beta, Interleukin-6.
- chemical , therapeutic use : Anti-Inflammatory Agents, Colchicine.
- geographic : New South Wales.
- blood : Acute Coronary Syndrome, Coronary Artery Disease.
- diagnosis : Acute Coronary Syndrome, Coronary Artery Disease.
- drug therapy : Acute Coronary Syndrome, Coronary Artery Disease.
- immunology : Acute Coronary Syndrome, Coronary Artery Disease, Myocardium.
- metabolism : Myocardium.
- Aged, Coronary Sinus, Down-Regulation, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Middle Aged, Time Factors, Treatment Outcome.

Abstract

Interleukin (IL)-1β, IL-18, and downstream IL-6 are key inflammatory cytokines in the pathogenesis of coronary artery disease. Colchicine is believed to block the NLRP3 inflammasome, a cytosolic complex responsible for the production of IL-1β and IL-18. In vivo effects of colchicine on cardiac cytokine release have not been previously studied. This study aimed to (1) assess the local cardiac production of inflammatory cytokines in patients with acute coronary syndromes (ACS), stable coronary artery disease and in controls; and (2) determine whether acute administration of colchicine inhibits their production.

DOI: 10.1161/JAHA.115.002128
PubMed: 26304941

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 002A87
to stream PubMed, to step Curation: 002A16

Links to Exploration step

pubmed:26304941

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Colchicine Acutely Suppresses Local Cardiac Production of Inflammatory Cytokines in Patients With an Acute Coronary Syndrome.</title>
<author><name sortKey="Martinez, Gonzalo J" sort="Martinez, Gonzalo J" uniqKey="Martinez G" first="Gonzalo J" last="Martínez">Gonzalo J. Martínez</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia (G.J.M., J.B., D.S.C., S.P.) Sydney Medical School, The University of Sydney, New South Wales, Australia (G.J.M., S.R., Q.X., C.B., D.S.C., S.P.) Department of Cardiology, Catholic University School of Medicine, Santiago, Chile (G.J.M.).</nlm:affiliation>
<orgName type="university">Université de Sydney</orgName>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Robertson, Stacy" sort="Robertson, Stacy" uniqKey="Robertson S" first="Stacy" last="Robertson">Stacy Robertson</name>
<affiliation wicri:level="4"><nlm:affiliation>Sydney Medical School, The University of Sydney, New South Wales, Australia (G.J.M., S.R., Q.X., C.B., D.S.C., S.P.) Heart Research Institute, Sydney, New South Wales, Australia (S.R., C.B., D.S.C., S.P.).</nlm:affiliation>
<orgName type="university">Université de Sydney</orgName>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Barraclough, Jennifer" sort="Barraclough, Jennifer" uniqKey="Barraclough J" first="Jennifer" last="Barraclough">Jennifer Barraclough</name>
<affiliation><nlm:affiliation>Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia (G.J.M., J.B., D.S.C., S.P.).</nlm:affiliation>
<wicri:noCountry code="subField">S.P.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Xia, Qiong" sort="Xia, Qiong" uniqKey="Xia Q" first="Qiong" last="Xia">Qiong Xia</name>
<affiliation wicri:level="4"><nlm:affiliation>Sydney Medical School, The University of Sydney, New South Wales, Australia (G.J.M., S.R., Q.X., C.B., D.S.C., S.P.).</nlm:affiliation>
<orgName type="university">Université de Sydney</orgName>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mallat, Ziad" sort="Mallat, Ziad" uniqKey="Mallat Z" first="Ziad" last="Mallat">Ziad Mallat</name>
<affiliation wicri:level="4"><nlm:affiliation>Institut National de la Santé et de la Recherche Médicale (INSERM), Paris-Cardiovascular Research Center, Paris, France (Z.M.) Division of Cardiovascular Medicine, Addenbrooke's Hospital, University of Cambridge, United Kingdom (Z.M.).</nlm:affiliation>
<orgName type="university">Université de Cambridge</orgName>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bursill, Christina" sort="Bursill, Christina" uniqKey="Bursill C" first="Christina" last="Bursill">Christina Bursill</name>
<affiliation wicri:level="4"><nlm:affiliation>Sydney Medical School, The University of Sydney, New South Wales, Australia (G.J.M., S.R., Q.X., C.B., D.S.C., S.P.) Heart Research Institute, Sydney, New South Wales, Australia (S.R., C.B., D.S.C., S.P.).</nlm:affiliation>
<orgName type="university">Université de Sydney</orgName>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Celermajer, David S" sort="Celermajer, David S" uniqKey="Celermajer D" first="David S" last="Celermajer">David S. Celermajer</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia (G.J.M., J.B., D.S.C., S.P.) Sydney Medical School, The University of Sydney, New South Wales, Australia (G.J.M., S.R., Q.X., C.B., D.S.C., S.P.) Heart Research Institute, Sydney, New South Wales, Australia (S.R., C.B., D.S.C., S.P.).</nlm:affiliation>
<orgName type="university">Université de Sydney</orgName>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Patel, Sanjay" sort="Patel, Sanjay" uniqKey="Patel S" first="Sanjay" last="Patel">Sanjay Patel</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia (G.J.M., J.B., D.S.C., S.P.) Sydney Medical School, The University of Sydney, New South Wales, Australia (G.J.M., S.R., Q.X., C.B., D.S.C., S.P.) Heart Research Institute, Sydney, New South Wales, Australia (S.R., C.B., D.S.C., S.P.).</nlm:affiliation>
<orgName type="university">Université de Sydney</orgName>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2015">2015</date>
<idno type="RBID">pubmed:26304941</idno>
<idno type="pmid">26304941</idno>
<idno type="doi">10.1161/JAHA.115.002128</idno>
<idno type="wicri:Area/PubMed/Corpus">002A87</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002A87</idno>
<idno type="wicri:Area/PubMed/Curation">002A16</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002A16</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002A16</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002A16</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Colchicine Acutely Suppresses Local Cardiac Production of Inflammatory Cytokines in Patients With an Acute Coronary Syndrome.</title>
<author><name sortKey="Martinez, Gonzalo J" sort="Martinez, Gonzalo J" uniqKey="Martinez G" first="Gonzalo J" last="Martínez">Gonzalo J. Martínez</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia (G.J.M., J.B., D.S.C., S.P.) Sydney Medical School, The University of Sydney, New South Wales, Australia (G.J.M., S.R., Q.X., C.B., D.S.C., S.P.) Department of Cardiology, Catholic University School of Medicine, Santiago, Chile (G.J.M.).</nlm:affiliation>
<orgName type="university">Université de Sydney</orgName>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Robertson, Stacy" sort="Robertson, Stacy" uniqKey="Robertson S" first="Stacy" last="Robertson">Stacy Robertson</name>
<affiliation wicri:level="4"><nlm:affiliation>Sydney Medical School, The University of Sydney, New South Wales, Australia (G.J.M., S.R., Q.X., C.B., D.S.C., S.P.) Heart Research Institute, Sydney, New South Wales, Australia (S.R., C.B., D.S.C., S.P.).</nlm:affiliation>
<orgName type="university">Université de Sydney</orgName>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Barraclough, Jennifer" sort="Barraclough, Jennifer" uniqKey="Barraclough J" first="Jennifer" last="Barraclough">Jennifer Barraclough</name>
<affiliation><nlm:affiliation>Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia (G.J.M., J.B., D.S.C., S.P.).</nlm:affiliation>
<wicri:noCountry code="subField">S.P.).</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Xia, Qiong" sort="Xia, Qiong" uniqKey="Xia Q" first="Qiong" last="Xia">Qiong Xia</name>
<affiliation wicri:level="4"><nlm:affiliation>Sydney Medical School, The University of Sydney, New South Wales, Australia (G.J.M., S.R., Q.X., C.B., D.S.C., S.P.).</nlm:affiliation>
<orgName type="university">Université de Sydney</orgName>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mallat, Ziad" sort="Mallat, Ziad" uniqKey="Mallat Z" first="Ziad" last="Mallat">Ziad Mallat</name>
<affiliation wicri:level="4"><nlm:affiliation>Institut National de la Santé et de la Recherche Médicale (INSERM), Paris-Cardiovascular Research Center, Paris, France (Z.M.) Division of Cardiovascular Medicine, Addenbrooke's Hospital, University of Cambridge, United Kingdom (Z.M.).</nlm:affiliation>
<orgName type="university">Université de Cambridge</orgName>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bursill, Christina" sort="Bursill, Christina" uniqKey="Bursill C" first="Christina" last="Bursill">Christina Bursill</name>
<affiliation wicri:level="4"><nlm:affiliation>Sydney Medical School, The University of Sydney, New South Wales, Australia (G.J.M., S.R., Q.X., C.B., D.S.C., S.P.) Heart Research Institute, Sydney, New South Wales, Australia (S.R., C.B., D.S.C., S.P.).</nlm:affiliation>
<orgName type="university">Université de Sydney</orgName>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Celermajer, David S" sort="Celermajer, David S" uniqKey="Celermajer D" first="David S" last="Celermajer">David S. Celermajer</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia (G.J.M., J.B., D.S.C., S.P.) Sydney Medical School, The University of Sydney, New South Wales, Australia (G.J.M., S.R., Q.X., C.B., D.S.C., S.P.) Heart Research Institute, Sydney, New South Wales, Australia (S.R., C.B., D.S.C., S.P.).</nlm:affiliation>
<orgName type="university">Université de Sydney</orgName>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Patel, Sanjay" sort="Patel, Sanjay" uniqKey="Patel S" first="Sanjay" last="Patel">Sanjay Patel</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia (G.J.M., J.B., D.S.C., S.P.) Sydney Medical School, The University of Sydney, New South Wales, Australia (G.J.M., S.R., Q.X., C.B., D.S.C., S.P.) Heart Research Institute, Sydney, New South Wales, Australia (S.R., C.B., D.S.C., S.P.).</nlm:affiliation>
<orgName type="university">Université de Sydney</orgName>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of the American Heart Association</title>
<idno type="eISSN">2047-9980</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute Coronary Syndrome (blood)</term>
<term>Acute Coronary Syndrome (diagnosis)</term>
<term>Acute Coronary Syndrome (drug therapy)</term>
<term>Acute Coronary Syndrome (immunology)</term>
<term>Aged</term>
<term>Anti-Inflammatory Agents (therapeutic use)</term>
<term>Biomarkers (blood)</term>
<term>Colchicine (therapeutic use)</term>
<term>Coronary Artery Disease (blood)</term>
<term>Coronary Artery Disease (diagnosis)</term>
<term>Coronary Artery Disease (drug therapy)</term>
<term>Coronary Artery Disease (immunology)</term>
<term>Coronary Sinus</term>
<term>Cytokines (blood)</term>
<term>Down-Regulation</term>
<term>Enzyme-Linked Immunosorbent Assay</term>
<term>Female</term>
<term>Humans</term>
<term>Inflammation Mediators (blood)</term>
<term>Interleukin-18 (blood)</term>
<term>Interleukin-1beta (blood)</term>
<term>Interleukin-6 (blood)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Myocardium (immunology)</term>
<term>Myocardium (metabolism)</term>
<term>New South Wales</term>
<term>Time Factors</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Anti-inflammatoires (usage thérapeutique)</term>
<term>Colchicine (usage thérapeutique)</term>
<term>Cytokines (sang)</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Interleukine-1 bêta (sang)</term>
<term>Interleukine-18 (sang)</term>
<term>Interleukine-6 (sang)</term>
<term>Maladie des artères coronaires (diagnostic)</term>
<term>Maladie des artères coronaires (immunologie)</term>
<term>Maladie des artères coronaires (sang)</term>
<term>Maladie des artères coronaires (traitement médicamenteux)</term>
<term>Marqueurs biologiques (sang)</term>
<term>Myocarde (immunologie)</term>
<term>Myocarde (métabolisme)</term>
<term>Mâle</term>
<term>Médiateurs de l'inflammation (sang)</term>
<term>Nouvelle-Galles du Sud</term>
<term>Régulation négative</term>
<term>Résultat thérapeutique</term>
<term>Sinus coronaire</term>
<term>Sujet âgé</term>
<term>Syndrome coronarien aigu (diagnostic)</term>
<term>Syndrome coronarien aigu (immunologie)</term>
<term>Syndrome coronarien aigu (sang)</term>
<term>Syndrome coronarien aigu (traitement médicamenteux)</term>
<term>Test ELISA</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term>
<term>Cytokines</term>
<term>Inflammation Mediators</term>
<term>Interleukin-18</term>
<term>Interleukin-1beta</term>
<term>Interleukin-6</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Inflammatory Agents</term>
<term>Colchicine</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>New South Wales</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Acute Coronary Syndrome</term>
<term>Coronary Artery Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Acute Coronary Syndrome</term>
<term>Coronary Artery Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Maladie des artères coronaires</term>
<term>Syndrome coronarien aigu</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Acute Coronary Syndrome</term>
<term>Coronary Artery Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Maladie des artères coronaires</term>
<term>Myocarde</term>
<term>Syndrome coronarien aigu</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Acute Coronary Syndrome</term>
<term>Coronary Artery Disease</term>
<term>Myocardium</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Myocardium</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Myocarde</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Cytokines</term>
<term>Interleukine-1 bêta</term>
<term>Interleukine-18</term>
<term>Interleukine-6</term>
<term>Maladie des artères coronaires</term>
<term>Marqueurs biologiques</term>
<term>Médiateurs de l'inflammation</term>
<term>Syndrome coronarien aigu</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Maladie des artères coronaires</term>
<term>Syndrome coronarien aigu</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anti-inflammatoires</term>
<term>Colchicine</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Coronary Sinus</term>
<term>Down-Regulation</term>
<term>Enzyme-Linked Immunosorbent Assay</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Time Factors</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Nouvelle-Galles du Sud</term>
<term>Régulation négative</term>
<term>Résultat thérapeutique</term>
<term>Sinus coronaire</term>
<term>Sujet âgé</term>
<term>Test ELISA</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Interleukin (IL)-1β, IL-18, and downstream IL-6 are key inflammatory cytokines in the pathogenesis of coronary artery disease. Colchicine is believed to block the NLRP3 inflammasome, a cytosolic complex responsible for the production of IL-1β and IL-18. In vivo effects of colchicine on cardiac cytokine release have not been previously studied. This study aimed to (1) assess the local cardiac production of inflammatory cytokines in patients with acute coronary syndromes (ACS), stable coronary artery disease and in controls; and (2) determine whether acute administration of colchicine inhibits their production.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26304941</PMID>
<DateCreated><Year>2015</Year>
<Month>08</Month>
<Day>25</Day>
</DateCreated>
<DateCompleted><Year>2016</Year>
<Month>05</Month>
<Day>04</Day>
</DateCompleted>
<DateRevised><Year>2015</Year>
<Month>10</Month>
<Day>16</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2047-9980</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>4</Volume>
<Issue>8</Issue>
<PubDate><Year>2015</Year>
<Month>Aug</Month>
<Day>24</Day>
</PubDate>
</JournalIssue>
<Title>Journal of the American Heart Association</Title>
<ISOAbbreviation>J Am Heart Assoc</ISOAbbreviation>
</Journal>
<ArticleTitle>Colchicine Acutely Suppresses Local Cardiac Production of Inflammatory Cytokines in Patients With an Acute Coronary Syndrome.</ArticleTitle>
<Pagination><MedlinePgn>e002128</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1161/JAHA.115.002128</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">e002128</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Interleukin (IL)-1β, IL-18, and downstream IL-6 are key inflammatory cytokines in the pathogenesis of coronary artery disease. Colchicine is believed to block the NLRP3 inflammasome, a cytosolic complex responsible for the production of IL-1β and IL-18. In vivo effects of colchicine on cardiac cytokine release have not been previously studied. This study aimed to (1) assess the local cardiac production of inflammatory cytokines in patients with acute coronary syndromes (ACS), stable coronary artery disease and in controls; and (2) determine whether acute administration of colchicine inhibits their production.</AbstractText>
<AbstractText Label="METHODS AND RESULTS" NlmCategory="RESULTS">Forty ACS patients, 33 with stable coronary artery disease, and 10 controls, were included. ACS and stable coronary artery disease patients were randomized to oral colchicine treatment (1 mg followed by 0.5 mg 1 hour later) or no colchicine, 6 to 24 hours prior to cardiac catheterization. Blood samples from the coronary sinus, aortic root (arterial), and lower right atrium (venous) were collected and tested for IL-1β, IL-18, and IL-6 using ELISA. In ACS patients, coronary sinus levels of IL-1β, IL-18, and IL-6 were significantly higher than arterial and venous levels (P=0.017, <0.001 and <0.001, respectively). Transcoronary (coronary sinus-arterial) gradients for IL-1β, IL-18, and IL-6 were highest in ACS patients and lowest in controls (P=0.077, 0.033, and 0.014, respectively). Colchicine administration significantly reduced transcoronary gradients of all 3 cytokines in ACS patients by 40% to 88% (P=0.028, 0.032, and 0.032, for IL-1β, IL-18, and IL-6, respectively).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">ACS patients exhibit increased local cardiac production of inflammatory cytokines. Short-term colchicine administration rapidly and significantly reduces levels of these cytokines.</AbstractText>
<CopyrightInformation>© 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Martínez</LastName>
<ForeName>Gonzalo J</ForeName>
<Initials>GJ</Initials>
<AffiliationInfo><Affiliation>Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia (G.J.M., J.B., D.S.C., S.P.) Sydney Medical School, The University of Sydney, New South Wales, Australia (G.J.M., S.R., Q.X., C.B., D.S.C., S.P.) Department of Cardiology, Catholic University School of Medicine, Santiago, Chile (G.J.M.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Robertson</LastName>
<ForeName>Stacy</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Sydney Medical School, The University of Sydney, New South Wales, Australia (G.J.M., S.R., Q.X., C.B., D.S.C., S.P.) Heart Research Institute, Sydney, New South Wales, Australia (S.R., C.B., D.S.C., S.P.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Barraclough</LastName>
<ForeName>Jennifer</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia (G.J.M., J.B., D.S.C., S.P.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xia</LastName>
<ForeName>Qiong</ForeName>
<Initials>Q</Initials>
<AffiliationInfo><Affiliation>Sydney Medical School, The University of Sydney, New South Wales, Australia (G.J.M., S.R., Q.X., C.B., D.S.C., S.P.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mallat</LastName>
<ForeName>Ziad</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>Institut National de la Santé et de la Recherche Médicale (INSERM), Paris-Cardiovascular Research Center, Paris, France (Z.M.) Division of Cardiovascular Medicine, Addenbrooke's Hospital, University of Cambridge, United Kingdom (Z.M.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bursill</LastName>
<ForeName>Christina</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Sydney Medical School, The University of Sydney, New South Wales, Australia (G.J.M., S.R., Q.X., C.B., D.S.C., S.P.) Heart Research Institute, Sydney, New South Wales, Australia (S.R., C.B., D.S.C., S.P.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Celermajer</LastName>
<ForeName>David S</ForeName>
<Initials>DS</Initials>
<AffiliationInfo><Affiliation>Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia (G.J.M., J.B., D.S.C., S.P.) Sydney Medical School, The University of Sydney, New South Wales, Australia (G.J.M., S.R., Q.X., C.B., D.S.C., S.P.) Heart Research Institute, Sydney, New South Wales, Australia (S.R., C.B., D.S.C., S.P.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Patel</LastName>
<ForeName>Sanjay</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia (G.J.M., J.B., D.S.C., S.P.) Sydney Medical School, The University of Sydney, New South Wales, Australia (G.J.M., S.R., Q.X., C.B., D.S.C., S.P.) Heart Research Institute, Sydney, New South Wales, Australia (S.R., C.B., D.S.C., S.P.).</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016449">Randomized Controlled Trial</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2015</Year>
<Month>08</Month>
<Day>24</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>J Am Heart Assoc</MedlineTA>
<NlmUniqueID>101580524</NlmUniqueID>
<ISSNLinking>2047-9980</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000893">Anti-Inflammatory Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016207">Cytokines</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C508585">IL1B protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C508600">IL6 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D018836">Inflammation Mediators</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D020382">Interleukin-18</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D053583">Interleukin-1beta</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D015850">Interleukin-6</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>SML2Y3J35T</RegistryNumber>
<NameOfSubstance UI="D003078">Colchicine</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>J Am Coll Cardiol. 2008 Jan 15;51(2):172-209</RefSource>
<PMID Version="1">18191745</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Arthritis Rheum. 2007 Oct;56(10):3183-8</RefSource>
<PMID Version="1">17907163</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2013 Oct 17;369(16):1522-8</RefSource>
<PMID Version="1">23992557</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Cardiovasc Pharmacol Ther. 2014 Jan;19(1):45-52</RefSource>
<PMID Version="1">24038016</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Eur Heart J. 2014 Mar;35(9):578-89</RefSource>
<PMID Version="1">24026779</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>JAMA. 2014 Sep 10;312(10):1006-15</RefSource>
<PMID Version="1">25173516</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Int J Cardiol. 2014 Oct 20;176(3):1321-2</RefSource>
<PMID Version="1">25139322</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Eur Heart J. 2015 Feb 7;36(6):377-84</RefSource>
<PMID Version="1">25079365</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Am Coll Cardiol. 2015 Mar 31;65(12):1175-86</RefSource>
<PMID Version="1">25814225</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Arterioscler Thromb Vasc Biol. 2003 Apr 1;23(4):656-60</RefSource>
<PMID Version="1">12615675</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Arterioscler Thromb Vasc Biol. 2003 Jul 1;23(7):1255-61</RefSource>
<PMID Version="1">12775578</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Arthritis Rheum. 2010 Apr;62(4):1060-8</RefSource>
<PMID Version="1">20131255</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nature. 2010 Apr 29;464(7293):1357-61</RefSource>
<PMID Version="1">20428172</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2010;5(7):e11765</RefSource>
<PMID Version="1">20668705</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Eur Heart J. 2010 Nov;31(22):2755-64</RefSource>
<PMID Version="1">20805110</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Immunol. 2011 Mar;12(3):204-12</RefSource>
<PMID Version="1">21321594</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Eur J Immunol. 2011 May;41(5):1203-17</RefSource>
<PMID Version="1">21523780</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am Heart J. 2011 Oct;162(4):597-605</RefSource>
<PMID Version="1">21982649</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Circ Res. 2012 Mar 16;110(6):875-88</RefSource>
<PMID Version="1">22427325</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Circ Cardiovasc Imaging. 2012 Jul;5(4):433-40</RefSource>
<PMID Version="1">22679059</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Circulation. 2012 Dec 4;126(23):2739-48</RefSource>
<PMID Version="1">23129601</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Am Coll Cardiol. 2013 Jan 29;61(4):404-10</RefSource>
<PMID Version="1">23265346</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Immunol. 2013 May;14(5):454-60</RefSource>
<PMID Version="1">23502856</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am Heart J. 2013 Aug;166(2):199-207.e15</RefSource>
<PMID Version="1">23895801</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Immunol. 2013 Oct;14(10):1030-2</RefSource>
<PMID Version="1">24048132</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Clin Sci (Lond). 2014 Feb;126(3):233-41</RefSource>
<PMID Version="1">23944632</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Am Coll Cardiol. 2009 Dec 1;54(23):2129-38</RefSource>
<PMID Version="1">19942084</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2000 Sep 7;343(10):732-4</RefSource>
<PMID Version="1">10974140</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Circ Res. 2001 Sep 28;89(7):E41-5</RefSource>
<PMID Version="1">11577031</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Circulation. 2001 Oct 2;104(14):1598-603</RefSource>
<PMID Version="1">11581135</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Clin Cardiol. 2001 Nov;24(11):701-4</RefSource>
<PMID Version="1">11714126</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Circ Res. 2002 Feb 8;90(2):E34-8</RefSource>
<PMID Version="1">11834721</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Circulation. 2002 Jul 2;106(1):24-30</RefSource>
<PMID Version="1">12093765</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2002 Jul 4;347(1):5-12</RefSource>
<PMID Version="1">12097534</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 1994 Aug 18;331(7):417-24</RefSource>
<PMID Version="1">7880233</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Arterioscler Thromb Vasc Biol. 1995 Dec;15(12):2284-9</RefSource>
<PMID Version="1">7489254</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Arterioscler Thromb Vasc Biol. 1996 Aug;16(8):1000-6</RefSource>
<PMID Version="1">8696938</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Circulation. 2005 Mar 22;111(11):1355-61</RefSource>
<PMID Version="1">15753219</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cardiovasc Res. 2005 Jun 1;66(3):583-93</RefSource>
<PMID Version="1">15914123</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Circulation. 2005 Aug 2;112(5):643-50</RefSource>
<PMID Version="1">16043644</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nature. 2006 Mar 9;440(7081):237-41</RefSource>
<PMID Version="1">16407889</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Pathol. 2006 Apr;168(4):1396-403</RefSource>
<PMID Version="1">16565512</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Cardiol. 2006 Jul 1;98(1):14-8</RefSource>
<PMID Version="1">16784912</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Circ Res. 2006 Jul 7;99(1):102-8</RefSource>
<PMID Version="1">16778130</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="CommentIn"><RefSource>J Am Heart Assoc. 2015 Aug;4(8):e002372</RefSource>
<PMID Version="1">26304942</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D054058" MajorTopicYN="N">Acute Coronary Syndrome</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000893" MajorTopicYN="N">Anti-Inflammatory Agents</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003078" MajorTopicYN="N">Colchicine</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003324" MajorTopicYN="N">Coronary Artery Disease</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D054326" MajorTopicYN="N">Coronary Sinus</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015536" MajorTopicYN="N">Down-Regulation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004797" MajorTopicYN="N">Enzyme-Linked Immunosorbent Assay</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018836" MajorTopicYN="N">Inflammation Mediators</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020382" MajorTopicYN="N">Interleukin-18</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053583" MajorTopicYN="N">Interleukin-1beta</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015850" MajorTopicYN="N">Interleukin-6</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009206" MajorTopicYN="N">Myocardium</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009517" MajorTopicYN="N" Type="Geographic">New South Wales</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<OtherID Source="NLM">PMC4599469</OtherID>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">atherosclerosis</Keyword>
<Keyword MajorTopicYN="N">coronary sinus sampling</Keyword>
<Keyword MajorTopicYN="N">cytokines</Keyword>
<Keyword MajorTopicYN="N">inflammation</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2015</Year>
<Month>8</Month>
<Day>26</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2015</Year>
<Month>8</Month>
<Day>26</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2016</Year>
<Month>5</Month>
<Day>5</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>epublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">26304941</ArticleId>
<ArticleId IdType="pii">JAHA.115.002128</ArticleId>
<ArticleId IdType="doi">10.1161/JAHA.115.002128</ArticleId>
<ArticleId IdType="pmc">PMC4599469</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Australie</li>
<li>Royaume-Uni</li>
</country>
<region><li>Angleterre</li>
<li>Angleterre de l'Est</li>
<li>Nouvelle-Galles du Sud</li>
</region>
<settlement><li>Cambridge</li>
<li>Sydney</li>
</settlement>
<orgName><li>Université de Cambridge</li>
<li>Université de Sydney</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Barraclough, Jennifer" sort="Barraclough, Jennifer" uniqKey="Barraclough J" first="Jennifer" last="Barraclough">Jennifer Barraclough</name>
</noCountry>
<country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Martinez, Gonzalo J" sort="Martinez, Gonzalo J" uniqKey="Martinez G" first="Gonzalo J" last="Martínez">Gonzalo J. Martínez</name>
</region>
<name sortKey="Bursill, Christina" sort="Bursill, Christina" uniqKey="Bursill C" first="Christina" last="Bursill">Christina Bursill</name>
<name sortKey="Celermajer, David S" sort="Celermajer, David S" uniqKey="Celermajer D" first="David S" last="Celermajer">David S. Celermajer</name>
<name sortKey="Patel, Sanjay" sort="Patel, Sanjay" uniqKey="Patel S" first="Sanjay" last="Patel">Sanjay Patel</name>
<name sortKey="Robertson, Stacy" sort="Robertson, Stacy" uniqKey="Robertson S" first="Stacy" last="Robertson">Stacy Robertson</name>
<name sortKey="Xia, Qiong" sort="Xia, Qiong" uniqKey="Xia Q" first="Qiong" last="Xia">Qiong Xia</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Mallat, Ziad" sort="Mallat, Ziad" uniqKey="Mallat Z" first="Ziad" last="Mallat">Ziad Mallat</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Checkpoint

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002E09 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 002E09 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    PubMed
   |étape=   Checkpoint
   |type=    RBID
   |clé=     pubmed:26304941
   |texte=   Colchicine Acutely Suppresses Local Cardiac Production of Inflammatory Cytokines in Patients With an Acute Coronary Syndrome.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i   -Sk "pubmed:26304941" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd   \
       | NlmPubMed2Wicri -a AustralieFrV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les relations entre la France et l'Australie

Colchicine Acutely Suppresses Local Cardiac Production of Inflammatory Cytokines in Patients With an Acute Coronary Syndrome.

Colchicine Acutely Suppresses Local Cardiac Production of Inflammatory Cytokines in Patients With an Acute Coronary Syndrome.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki