AustralieFrV1, PubMed, Checkpoint, bibRecord, 002D91

Compensation in Preclinical Huntington's Disease: Evidence From the Track-On HD Study.

Identifieur interne : 002D91 ( PubMed/Checkpoint ); précédent : 002D90; suivant : 002D92

Compensation in Preclinical Huntington's Disease: Evidence From the Track-On HD Study.

Auteurs : Stefan Klöppel [Allemagne] ; Sarah Gregory [Royaume-Uni] ; Elisa Scheller [Allemagne] ; Lora Minkova [Allemagne] ; Adeel Razi [Pakistan] ; Alexandra Durr ; Raymund A C. Roos [Pays-Bas] ; Blair R. Leavitt [Canada] ; Marina Papoutsi [Royaume-Uni] ; G Bernhard Landwehrmeyer [Allemagne] ; Ralf Reilmann [Allemagne] ; Beth Borowsky [États-Unis] ; Hans Johnson [États-Unis] ; James A. Mills [États-Unis] ; Gail Owen [Royaume-Uni] ; Julie Stout [Australie] ; Rachael I. Scahill [Royaume-Uni] ; Jeffrey D. Long [États-Unis] ; Geraint Rees [Royaume-Uni] ; Sarah J. Tabrizi [Royaume-Uni]

Source :

EBioMedicine [ 2352-3964 ] ; 2015.

RBID : pubmed:26629536

Descripteurs français

KwdFr :
- Cartographie cérébrale, Connectome, Femelle, Humains, Hétérozygote, Imagerie par résonance magnétique, Maladie de Huntington (anatomopathologie), Maladie de Huntington (diagnostic), Maladie de Huntington (génétique), Maladie de Huntington (physiopathologie), Mutation, Mâle, Mémoire à court terme, Performance psychomotrice, Protéine huntingtine, Protéines de tissu nerveux (génétique), Sujet âgé, Sujet âgé de 80 ans ou plus, Traitement d'image par ordinateur, Études cas-témoins.
MESH :
- anatomopathologie : Maladie de Huntington.
- diagnostic : Maladie de Huntington.
- génétique : Maladie de Huntington, Protéines de tissu nerveux.
- physiopathologie : Maladie de Huntington.
- Cartographie cérébrale, Connectome, Femelle, Humains, Hétérozygote, Imagerie par résonance magnétique, Mutation, Mâle, Mémoire à court terme, Performance psychomotrice, Protéine huntingtine, Sujet âgé, Sujet âgé de 80 ans ou plus, Traitement d'image par ordinateur, Études cas-témoins.

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Brain Mapping, Case-Control Studies, Connectome, Female, Heterozygote, Humans, Huntingtin Protein, Huntington Disease (diagnosis), Huntington Disease (genetics), Huntington Disease (pathology), Huntington Disease (physiopathology), Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Memory, Short-Term, Mutation, Nerve Tissue Proteins (genetics), Psychomotor Performance.
MESH :
- chemical , genetics : Nerve Tissue Proteins.
- chemical : Huntingtin Protein.
- diagnosis : Huntington Disease.
- genetics : Huntington Disease.
- pathology : Huntington Disease.
- physiopathology : Huntington Disease.
- Aged, Aged, 80 and over, Brain Mapping, Case-Control Studies, Connectome, Female, Heterozygote, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Memory, Short-Term, Mutation, Psychomotor Performance.

Abstract

Cognitive and motor task performance in premanifest Huntington's disease (HD) gene-carriers is often within normal ranges prior to clinical diagnosis, despite loss of brain volume in regions involved in these tasks. This indicates ongoing compensation, with the brain maintaining function in the presence of neuronal loss. However, thus far, compensatory processes in HD have not been modeled explicitly. Using a new model, which incorporates individual variability related to structural change and behavior, we sought to identify functional correlates of compensation in premanifest-HD gene-carriers.

DOI: 10.1016/j.ebiom.2015.08.002
PubMed: 26629536

Affiliations:

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<author><name sortKey="Johnson, Hans" sort="Johnson, Hans" uniqKey="Johnson H" first="Hans" last="Johnson">Hans Johnson</name>
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<author><name sortKey="Stout, Julie" sort="Stout, Julie" uniqKey="Stout J" first="Julie" last="Stout">Julie Stout</name>
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<author><name sortKey="Long, Jeffrey D" sort="Long, Jeffrey D" uniqKey="Long J" first="Jeffrey D" last="Long">Jeffrey D. Long</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Rees, Geraint" sort="Rees, Geraint" uniqKey="Rees G" first="Geraint" last="Rees">Geraint Rees</name>
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<author><name sortKey="Tabrizi, Sarah J" sort="Tabrizi, Sarah J" uniqKey="Tabrizi S" first="Sarah J" last="Tabrizi">Sarah J. Tabrizi</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
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<region type="région" nuts="1">Grand Londres</region>
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<author><name sortKey="Minkova, Lora" sort="Minkova, Lora" uniqKey="Minkova L" first="Lora" last="Minkova">Lora Minkova</name>
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<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Albert-Ludwigs-University Freiburg, University Medical Center, Division Freiburg Brain Imaging, Freiburg, Germany ; Albert-Ludwigs-University Freiburg, University Medical Center, Department of Psychiatry and Psychotherapy, Freiburg, Germany ; Albert-Ludwigs-University Freiburg, Department of Psychology, Laboratory for Biological and Personality Psychology, Freiburg</wicri:regionArea>
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<author><name sortKey="Razi, Adeel" sort="Razi, Adeel" uniqKey="Razi A" first="Adeel" last="Razi">Adeel Razi</name>
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<country xml:lang="fr">Pakistan</country>
<wicri:regionArea>Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK ; Department of Electronic Engineering, N.E.D University of Engineering & Technology, Karachi</wicri:regionArea>
<orgName type="university">University College de Londres</orgName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Durr, Alexandra" sort="Durr, Alexandra" uniqKey="Durr A" first="Alexandra" last="Durr">Alexandra Durr</name>
<affiliation><nlm:affiliation>APHP Department of Genetics, Groupe Hospitalier Pitié-Salpêtrière, UPMC Université Paris VI UMR_S1127, Paris France ; Institut du Cerveau et de la Moelle, INSERM U1127, CNRS UMR7225, UPMC Université Paris VI UMR_S1127, Paris France.</nlm:affiliation>
<wicri:noCountry code="subField">Paris France</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Roos, Raymund A C" sort="Roos, Raymund A C" uniqKey="Roos R" first="Raymund A C" last="Roos">Raymund A C. Roos</name>
<affiliation wicri:level="3"><nlm:affiliation>Leiden University Medical Center, Department of Neurology, Leiden, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Leiden University Medical Center, Department of Neurology, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Leavitt, Blair R" sort="Leavitt, Blair R" uniqKey="Leavitt B" first="Blair R" last="Leavitt">Blair R. Leavitt</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia</wicri:regionArea>
<wicri:noRegion>University of British Columbia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Papoutsi, Marina" sort="Papoutsi, Marina" uniqKey="Papoutsi M" first="Marina" last="Papoutsi">Marina Papoutsi</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author><name sortKey="Landwehrmeyer, G Bernhard" sort="Landwehrmeyer, G Bernhard" uniqKey="Landwehrmeyer G" first="G Bernhard" last="Landwehrmeyer">G Bernhard Landwehrmeyer</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Ulm University, Ulm, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Ulm University, Ulm</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Reilmann, Ralf" sort="Reilmann, Ralf" uniqKey="Reilmann R" first="Ralf" last="Reilmann">Ralf Reilmann</name>
<affiliation wicri:level="3"><nlm:affiliation>George-Huntington-Institute, Muenster, Germany ; University of Tuebingen, Department of Neurodegenerative Diseases and Hertie-Institute for Clinical Brain Research, Tuebingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>George-Huntington-Institute, Muenster, Germany ; University of Tuebingen, Department of Neurodegenerative Diseases and Hertie-Institute for Clinical Brain Research, Tuebingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Borowsky, Beth" sort="Borowsky, Beth" uniqKey="Borowsky B" first="Beth" last="Borowsky">Beth Borowsky</name>
<affiliation wicri:level="2"><nlm:affiliation>CHDI Management/CHDI Foundation, Princeton, NJ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>CHDI Management/CHDI Foundation, Princeton, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Johnson, Hans" sort="Johnson, Hans" uniqKey="Johnson H" first="Hans" last="Johnson">Hans Johnson</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Electrical and Computer Engineering, University of Iowa, Iowa City, IA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Electrical and Computer Engineering, University of Iowa, Iowa City, IA</wicri:regionArea>
<placeName><region type="state">Iowa</region>
<settlement type="city">Iowa City</settlement>
</placeName>
<orgName type="university">Université de l'Iowa</orgName>
</affiliation>
</author>
<author><name sortKey="Mills, James A" sort="Mills, James A" uniqKey="Mills J" first="James A" last="Mills">James A. Mills</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA</wicri:regionArea>
<placeName><region type="state">Iowa</region>
<settlement type="city">Iowa City</settlement>
</placeName>
<orgName type="university">Université de l'Iowa</orgName>
</affiliation>
</author>
<author><name sortKey="Owen, Gail" sort="Owen, Gail" uniqKey="Owen G" first="Gail" last="Owen">Gail Owen</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author><name sortKey="Stout, Julie" sort="Stout, Julie" uniqKey="Stout J" first="Julie" last="Stout">Julie Stout</name>
<affiliation wicri:level="3"><nlm:affiliation>School of Psychological Sciences and Institute of Clinical and Cognitive Neuroscience, Monash University, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Psychological Sciences and Institute of Clinical and Cognitive Neuroscience, Monash University, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Scahill, Rachael I" sort="Scahill, Rachael I" uniqKey="Scahill R" first="Rachael I" last="Scahill">Rachael I. Scahill</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author><name sortKey="Long, Jeffrey D" sort="Long, Jeffrey D" uniqKey="Long J" first="Jeffrey D" last="Long">Jeffrey D. Long</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, USA ; Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, USA ; Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA</wicri:regionArea>
<placeName><region type="state">Iowa</region>
<settlement type="city">Iowa City</settlement>
</placeName>
<orgName type="university">Université de l'Iowa</orgName>
</affiliation>
</author>
<author><name sortKey="Rees, Geraint" sort="Rees, Geraint" uniqKey="Rees G" first="Geraint" last="Rees">Geraint Rees</name>
<affiliation wicri:level="4"><nlm:affiliation>Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK ; Institute of Cognitive Neuroscience, University College London, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK ; Institute of Cognitive Neuroscience, University College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author><name sortKey="Tabrizi, Sarah J" sort="Tabrizi, Sarah J" uniqKey="Tabrizi S" first="Sarah J" last="Tabrizi">Sarah J. Tabrizi</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
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<series><title level="j">EBioMedicine</title>
<idno type="eISSN">2352-3964</idno>
<imprint><date when="2015" type="published">2015</date>
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<term>Aged, 80 and over</term>
<term>Brain Mapping</term>
<term>Case-Control Studies</term>
<term>Connectome</term>
<term>Female</term>
<term>Heterozygote</term>
<term>Humans</term>
<term>Huntingtin Protein</term>
<term>Huntington Disease (diagnosis)</term>
<term>Huntington Disease (genetics)</term>
<term>Huntington Disease (pathology)</term>
<term>Huntington Disease (physiopathology)</term>
<term>Image Processing, Computer-Assisted</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Memory, Short-Term</term>
<term>Mutation</term>
<term>Nerve Tissue Proteins (genetics)</term>
<term>Psychomotor Performance</term>
</keywords>
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<term>Femelle</term>
<term>Humains</term>
<term>Hétérozygote</term>
<term>Imagerie par résonance magnétique</term>
<term>Maladie de Huntington (anatomopathologie)</term>
<term>Maladie de Huntington (diagnostic)</term>
<term>Maladie de Huntington (génétique)</term>
<term>Maladie de Huntington (physiopathologie)</term>
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<front><div type="abstract" xml:lang="en">Cognitive and motor task performance in premanifest Huntington's disease (HD) gene-carriers is often within normal ranges prior to clinical diagnosis, despite loss of brain volume in regions involved in these tasks. This indicates ongoing compensation, with the brain maintaining function in the presence of neuronal loss. However, thus far, compensatory processes in HD have not been modeled explicitly. Using a new model, which incorporates individual variability related to structural change and behavior, we sought to identify functional correlates of compensation in premanifest-HD gene-carriers.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26629536</PMID>
<DateCreated><Year>2015</Year>
<Month>12</Month>
<Day>02</Day>
</DateCreated>
<DateCompleted><Year>2016</Year>
<Month>09</Month>
<Day>26</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>09</Month>
<Day>22</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">2352-3964</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>2</Volume>
<Issue>10</Issue>
<PubDate><Year>2015</Year>
<Month>Oct</Month>
</PubDate>
</JournalIssue>
<Title>EBioMedicine</Title>
<ISOAbbreviation>EBioMedicine</ISOAbbreviation>
</Journal>
<ArticleTitle>Compensation in Preclinical Huntington's Disease: Evidence From the Track-On HD Study.</ArticleTitle>
<Pagination><MedlinePgn>1420-9</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ebiom.2015.08.002</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Cognitive and motor task performance in premanifest Huntington's disease (HD) gene-carriers is often within normal ranges prior to clinical diagnosis, despite loss of brain volume in regions involved in these tasks. This indicates ongoing compensation, with the brain maintaining function in the presence of neuronal loss. However, thus far, compensatory processes in HD have not been modeled explicitly. Using a new model, which incorporates individual variability related to structural change and behavior, we sought to identify functional correlates of compensation in premanifest-HD gene-carriers.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We investigated the modulatory effects of regional brain atrophy, indexed by structural measures of disease load, on the relationship between performance and brain activity (or connectivity) using task-based and resting-state functional MRI.</AbstractText>
<AbstractText Label="FINDINGS" NlmCategory="RESULTS">Consistent with compensation, as atrophy increased performance-related activity increased in the right parietal cortex during a working memory task. Similarly, increased functional coupling between the right dorsolateral prefrontal cortex and a left hemisphere network in the resting-state predicted better cognitive performance as atrophy increased. Such patterns were not detectable for the left hemisphere or for motor tasks.</AbstractText>
<AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">Our findings provide evidence for active compensatory processes in premanifest-HD for cognitive demands and suggest a higher vulnerability of the left hemisphere to the effects of regional atrophy.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Klöppel</LastName>
<ForeName>Stefan</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Albert-Ludwigs-University Freiburg, University Medical Center, Division Freiburg Brain Imaging, Freiburg, Germany ; Albert-Ludwigs-University Freiburg, University Medical Center, Department of Psychiatry and Psychotherapy, Freiburg, Germany ; Albert-Ludwigs-University Freiburg, University Medical Center, Department of Neurology, Freiburg, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gregory</LastName>
<ForeName>Sarah</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Scheller</LastName>
<ForeName>Elisa</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Albert-Ludwigs-University Freiburg, University Medical Center, Division Freiburg Brain Imaging, Freiburg, Germany ; Albert-Ludwigs-University Freiburg, University Medical Center, Department of Psychiatry and Psychotherapy, Freiburg, Germany ; Albert-Ludwigs-University Freiburg, Department of Psychology, Laboratory for Biological and Personality Psychology, Freiburg, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Minkova</LastName>
<ForeName>Lora</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Albert-Ludwigs-University Freiburg, University Medical Center, Division Freiburg Brain Imaging, Freiburg, Germany ; Albert-Ludwigs-University Freiburg, University Medical Center, Department of Psychiatry and Psychotherapy, Freiburg, Germany ; Albert-Ludwigs-University Freiburg, Department of Psychology, Laboratory for Biological and Personality Psychology, Freiburg, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Razi</LastName>
<ForeName>Adeel</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK ; Department of Electronic Engineering, N.E.D University of Engineering & Technology, Karachi, Pakistan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Durr</LastName>
<ForeName>Alexandra</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>APHP Department of Genetics, Groupe Hospitalier Pitié-Salpêtrière, UPMC Université Paris VI UMR_S1127, Paris France ; Institut du Cerveau et de la Moelle, INSERM U1127, CNRS UMR7225, UPMC Université Paris VI UMR_S1127, Paris France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Roos</LastName>
<ForeName>Raymund A C</ForeName>
<Initials>RA</Initials>
<AffiliationInfo><Affiliation>Leiden University Medical Center, Department of Neurology, Leiden, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Leavitt</LastName>
<ForeName>Blair R</ForeName>
<Initials>BR</Initials>
<AffiliationInfo><Affiliation>Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Papoutsi</LastName>
<ForeName>Marina</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Landwehrmeyer</LastName>
<ForeName>G Bernhard</ForeName>
<Initials>GB</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Ulm University, Ulm, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Reilmann</LastName>
<ForeName>Ralf</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>George-Huntington-Institute, Muenster, Germany ; University of Tuebingen, Department of Neurodegenerative Diseases and Hertie-Institute for Clinical Brain Research, Tuebingen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Borowsky</LastName>
<ForeName>Beth</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>CHDI Management/CHDI Foundation, Princeton, NJ, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Johnson</LastName>
<ForeName>Hans</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Department of Electrical and Computer Engineering, University of Iowa, Iowa City, IA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mills</LastName>
<ForeName>James A</ForeName>
<Initials>JA</Initials>
<AffiliationInfo><Affiliation>Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Owen</LastName>
<ForeName>Gail</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Stout</LastName>
<ForeName>Julie</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>School of Psychological Sciences and Institute of Clinical and Cognitive Neuroscience, Monash University, Melbourne, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Scahill</LastName>
<ForeName>Rachael I</ForeName>
<Initials>RI</Initials>
<AffiliationInfo><Affiliation>Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Long</LastName>
<ForeName>Jeffrey D</ForeName>
<Initials>JD</Initials>
<AffiliationInfo><Affiliation>Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, USA ; Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rees</LastName>
<ForeName>Geraint</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK ; Institute of Cognitive Neuroscience, University College London, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tabrizi</LastName>
<ForeName>Sarah J</ForeName>
<Initials>SJ</Initials>
<AffiliationInfo><Affiliation>Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><CollectiveName>Track-On investigators</CollectiveName>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>091593</GrantID>
<Agency>Wellcome Trust</Agency>
<Country>United Kingdom</Country>
</Grant>
<Grant><GrantID>100227</GrantID>
<Agency>Wellcome Trust</Agency>
<Country>United Kingdom</Country>
</Grant>
<Grant><GrantID>MR/L012936/1</GrantID>
<Agency>Medical Research Council</Agency>
<Country>United Kingdom</Country>
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<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>EBioMedicine. 2015 Oct;2(10):1288-9</RefSource>
<PMID Version="1">26629512</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="CommentIn"><RefSource>EBioMedicine. 2015 Oct;2(10):1286-7</RefSource>
<PMID Version="1">26629511</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Magn Reson Imaging. 2012 Jul;36(1):39-54</RefSource>
<PMID Version="1">22314879</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Brain. 2009 Jun;132(Pt 6):1624-32</RefSource>
<PMID Version="1">19369489</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurology. 1998 May;50(5):1357-65</RefSource>
<PMID Version="1">9595987</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Lancet Neurol. 2013 Jul;12(7):637-49</RefSource>
<PMID Version="1">23664844</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Trends Cogn Sci. 2013 Oct;17(10):502-9</RefSource>
<PMID Version="1">24018144</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Brain Struct Funct. 2015 Jan;220(1):501-12</RefSource>
<PMID Version="1">24240602</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Rev Neurosci. 2013 May;14(5):365-76</RefSource>
<PMID Version="1">23571845</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Lancet Neurol. 2011 Jan;10(1):83-98</RefSource>
<PMID Version="1">21163446</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Eur J Neurol. 2013 Feb;20(2):315-21</RefSource>
<PMID Version="1">22925174</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Lancet Neurol. 2012 Jan;11(1):42-53</RefSource>
<PMID Version="1">22137354</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2007 Jun 15;22(8):1169-73</RefSource>
<PMID Version="1">17394246</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Lancet Neurol. 2009 Sep;8(9):791-801</RefSource>
<PMID Version="1">19646924</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Brain Cogn. 2013 Oct;83(1):80-91</RefSource>
<PMID Version="1">23938592</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Brain. 2012 Apr;135(Pt 4):1165-79</RefSource>
<PMID Version="1">22505631</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2010 Dec 15;25(16):2858-62</RefSource>
<PMID Version="1">20818671</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Lancet Neurol. 2011 Jan;10(1):31-42</RefSource>
<PMID Version="1">21130037</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3131-6</RefSource>
<PMID Version="1">22323591</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2012 Jan 6;287(2):1361-70</RefSource>
<PMID Version="1">22123819</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neuroimage. 2007 Oct 15;38(1):95-113</RefSource>
<PMID Version="1">17761438</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neuropsychologia. 1971 Mar;9(1):97-113</RefSource>
<PMID Version="1">5146491</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neuroimage. 2013 Jul 15;75:146-54</RefSource>
<PMID Version="1">23501047</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2014 Apr 15;29(5):673-83</RefSource>
<PMID Version="1">24757115</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2014;9(12):e114569</RefSource>
<PMID Version="1">25541992</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Exp Neurol. 2013 Jan;239:218-28</RefSource>
<PMID Version="1">23123406</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Rev Neurol. 2014 Apr;10(4):204-16</RefSource>
<PMID Version="1">24614516</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 1997 May;41(5):689-92</RefSource>
<PMID Version="1">9153534</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Brain. 2007 Nov;130(Pt 11):2845-57</RefSource>
<PMID Version="1">17855375</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neuroimage. 2011 Sep 15;58(2):442-57</RefSource>
<PMID Version="1">21310247</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>R Soc Open Sci. 2014 Nov 19;1(3):140216</RefSource>
<PMID Version="1">26064558</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Hum Brain Mapp. 2005 May;25(1):46-59</RefSource>
<PMID Version="1">15846822</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Philos Trans R Soc Lond B Biol Sci. 2005 May 29;360(1457):1001-13</RefSource>
<PMID Version="1">16087444</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 1996 Mar;11(2):136-42</RefSource>
<PMID Version="1">8684382</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Front Psychiatry. 2014 Sep 29;5:132</RefSource>
<PMID Version="1">25324786</PMID>
</CommentsCorrections>
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   |texte=   Compensation in Preclinical Huntington's Disease: Evidence From the Track-On HD Study.
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	Serveur d'exploration sur les relations entre la France et l'Australie
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Compensation in Preclinical Huntington's Disease: Evidence From the Track-On HD Study.

Compensation in Preclinical Huntington's Disease: Evidence From the Track-On HD Study.

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