Daclatasvir plus peginterferon alfa and ribavirin for treatment-naive chronic hepatitis C genotype 1 or 4 infection: a randomised study.
Identifieur interne : 002D48 ( PubMed/Checkpoint ); précédent : 002D47; suivant : 002D49Daclatasvir plus peginterferon alfa and ribavirin for treatment-naive chronic hepatitis C genotype 1 or 4 infection: a randomised study.
Auteurs : Christophe Hézode [France] ; Gideon M. Hirschfield [Royaume-Uni] ; Wayne Ghesquiere [Canada] ; William Sievert [Australie] ; Maribel Rodriguez-Torres [Porto Rico] ; Stephen D. Shafran [Canada] ; Paul J. Thuluvath [États-Unis] ; Harvey A. Tatum [États-Unis] ; Imam Waked [Égypte] ; Gamal Esmat [Égypte] ; Eric J. Lawitz [États-Unis] ; Vinod K. Rustgi [États-Unis] ; Stanislas Pol [France] ; Nina Weis [Danemark] ; Paul J. Pockros [États-Unis] ; Marc Bourlière [France] ; Lawrence Serfaty [France] ; John M. Vierling [États-Unis] ; Michael W. Fried [États-Unis] ; Ola Weiland [Suède] ; Maurizia R. Brunetto [Italie] ; Gregory T. Everson [États-Unis] ; Stefan Zeuzem [Allemagne] ; Paul Y. Kwo [États-Unis] ; Mark Sulkowski [États-Unis] ; Norbert Br U [États-Unis] ; Dennis Hernandez [États-Unis] ; Fiona Mcphee [États-Unis] ; Megan Wind-Rotolo [États-Unis] ; Zhaohui Liu [États-Unis] ; Stephanie Noviello [États-Unis] ; Eric A. Hughes [États-Unis] ; Philip D. Yin [États-Unis] ; Steven Schnittman [États-Unis]Source :
- Gut [ 1468-3288 ] ; 2015.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Association de médicaments, Calendrier d'administration des médicaments, Charge virale (), Femelle, Génotype, Humains, Hépatite C chronique (), Hépatite C chronique (génétique), Hépatite C chronique (traitement médicamenteux), Hépatite C chronique (virologie), Imidazoles (administration et posologie), Induction de rémission, Interféron alpha (administration et posologie), Jeune adulte, Mâle, Méthode en double aveugle, Polyéthylène glycols (administration et posologie), Protéines recombinantes (administration et posologie), Ribavirine (administration et posologie), Résultat thérapeutique, Sujet âgé.
- MESH :
- administration et posologie : Imidazoles, Interféron alpha, Polyéthylène glycols, Protéines recombinantes, Ribavirine.
- génétique : Hépatite C chronique.
- traitement médicamenteux : Hépatite C chronique.
- virologie : Hépatite C chronique.
- Adolescent, Adulte, Adulte d'âge moyen, Association de médicaments, Calendrier d'administration des médicaments, Charge virale, Femelle, Génotype, Humains, Hépatite C chronique, Induction de rémission, Jeune adulte, Mâle, Méthode en double aveugle, Résultat thérapeutique, Sujet âgé.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Double-Blind Method, Drug Administration Schedule, Drug Therapy, Combination, Female, Genotype, Hepatitis C, Chronic (classification), Hepatitis C, Chronic (drug therapy), Hepatitis C, Chronic (genetics), Hepatitis C, Chronic (virology), Humans, Imidazoles (administration & dosage), Interferon-alpha (administration & dosage), Male, Middle Aged, Polyethylene Glycols (administration & dosage), Recombinant Proteins (administration & dosage), Remission Induction, Ribavirin (administration & dosage), Treatment Outcome, Viral Load (drug effects), Young Adult.
- MESH :
- chemical , administration & dosage : Imidazoles, Interferon-alpha, Polyethylene Glycols, Recombinant Proteins, Ribavirin.
- classification : Hepatitis C, Chronic.
- drug effects : Viral Load.
- drug therapy : Hepatitis C, Chronic.
- genetics : Hepatitis C, Chronic.
- virology : Hepatitis C, Chronic.
- Adolescent, Adult, Aged, Double-Blind Method, Drug Administration Schedule, Drug Therapy, Combination, Female, Genotype, Humans, Male, Middle Aged, Remission Induction, Treatment Outcome, Young Adult.
Abstract
To evaluate the safety and efficacy of daclatasvir, an HCV NS5A inhibitor with pangenotypic activity, administered with peginterferon-alfa-2a/ribavirin.
DOI: 10.1136/gutjnl-2014-307498
PubMed: 25080450
Affiliations:
- Allemagne, Australie, Canada, Danemark, France, Italie, Porto Rico, Royaume-Uni, Suède, Égypte, États-Unis
- Angleterre, Californie, Caroline du Nord, Colorado, Connecticut, District de Darmstadt, Hesse (Land), Indiana, Maryland, Midlands de l'Ouest, New Jersey, Oklahoma, Provence-Alpes-Côte d'Azur, Svealand, Texas, Toscane, Victoria (État), Virginie, État de New York, Île-de-France
- Birmingham, Créteil, Francfort-sur-le-Main, Marseille, Melbourne, Paris, Pise, Stockholm
- Université Paris-Descartes, Université de Birmingham
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:25080450Le document en format XML
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Peters VA Medical Center, Bronx, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>James J. Peters VA Medical Center, Bronx, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Hernandez, Dennis" sort="Hernandez, Dennis" uniqKey="Hernandez D" first="Dennis" last="Hernandez">Dennis Hernandez</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb, Clinical Research and Development, Wallingford, Connecticut, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb, Clinical Research and Development, Wallingford, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Mcphee, Fiona" sort="Mcphee, Fiona" uniqKey="Mcphee F" first="Fiona" last="Mcphee">Fiona Mcphee</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb, Clinical Research and Development, Wallingford, Connecticut, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb, Clinical Research and Development, Wallingford, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Wind Rotolo, Megan" sort="Wind Rotolo, Megan" uniqKey="Wind Rotolo M" first="Megan" last="Wind-Rotolo">Megan Wind-Rotolo</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb, Research and Development, Princeton, New Jersey, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb, Research and Development, Princeton, New Jersey</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Liu, Zhaohui" sort="Liu, Zhaohui" uniqKey="Liu Z" first="Zhaohui" last="Liu">Zhaohui Liu</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb Research and Development, Hopewell, New Jersey, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb Research and Development, Hopewell, New Jersey</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Noviello, Stephanie" sort="Noviello, Stephanie" uniqKey="Noviello S" first="Stephanie" last="Noviello">Stephanie Noviello</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb, Research and Development, Princeton, New Jersey, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb, Research and Development, Princeton, New Jersey</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Hughes, Eric A" sort="Hughes, Eric A" uniqKey="Hughes E" first="Eric A" last="Hughes">Eric A. Hughes</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb, Research and Development, Princeton, New Jersey, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb, Research and Development, Princeton, New Jersey</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Yin, Philip D" sort="Yin, Philip D" uniqKey="Yin P" first="Philip D" last="Yin">Philip D. Yin</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb, Clinical Research and Development, Wallingford, Connecticut, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb, Clinical Research and Development, Wallingford, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Schnittman, Steven" sort="Schnittman, Steven" uniqKey="Schnittman S" first="Steven" last="Schnittman">Steven Schnittman</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb, Clinical Research and Development, Wallingford, Connecticut, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb, Clinical Research and Development, Wallingford, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25080450</idno><idno type="pmid">25080450</idno><idno type="doi">10.1136/gutjnl-2014-307498</idno><idno type="wicri:Area/PubMed/Corpus">002C95</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002C95</idno><idno type="wicri:Area/PubMed/Curation">002C21</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002C21</idno><idno type="wicri:Area/PubMed/Checkpoint">002C21</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002C21</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Daclatasvir plus peginterferon alfa and ribavirin for treatment-naive chronic hepatitis C genotype 1 or 4 infection: a randomised study.</title><author><name sortKey="Hezode, Christophe" sort="Hezode, Christophe" uniqKey="Hezode C" first="Christophe" last="Hézode">Christophe Hézode</name><affiliation wicri:level="3"><nlm:affiliation>Hôpital Henri Mondor, AP-HP, Université Paris-Est, Inserm U955, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Henri Mondor, AP-HP, Université Paris-Est, Inserm U955, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Hirschfield, Gideon M" sort="Hirschfield, Gideon M" uniqKey="Hirschfield G" first="Gideon M" last="Hirschfield">Gideon M. Hirschfield</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Liver Research and NIHR Biomedical Research Unit, University of Birmingham, Birmingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Liver Research and NIHR Biomedical Research Unit, University of Birmingham, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region><settlement type="city">Birmingham</settlement></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Ghesquiere, Wayne" sort="Ghesquiere, Wayne" uniqKey="Ghesquiere W" first="Wayne" last="Ghesquiere">Wayne Ghesquiere</name><affiliation wicri:level="1"><nlm:affiliation>Vancouver Island Health Authority & University of British Columbia, Victoria, British Columbia, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Vancouver Island Health Authority & University of British Columbia, Victoria, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Sievert, William" sort="Sievert, William" uniqKey="Sievert W" first="William" last="Sievert">William Sievert</name><affiliation wicri:level="3"><nlm:affiliation>Monash University and Monash Health, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Monash University and Monash Health, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Rodriguez Torres, Maribel" sort="Rodriguez Torres, Maribel" uniqKey="Rodriguez Torres M" first="Maribel" last="Rodriguez-Torres">Maribel Rodriguez-Torres</name><affiliation wicri:level="1"><nlm:affiliation>Fundacion De Investigacion, San Juan Bautista School of Medicine, San Juan, Puerto Rico.</nlm:affiliation><country xml:lang="fr">Porto Rico</country><wicri:regionArea>Fundacion De Investigacion, San Juan Bautista School of Medicine, San Juan</wicri:regionArea><wicri:noRegion>San Juan</wicri:noRegion></affiliation></author><author><name sortKey="Shafran, Stephen D" sort="Shafran, Stephen D" uniqKey="Shafran S" first="Stephen D" last="Shafran">Stephen D. Shafran</name><affiliation wicri:level="1"><nlm:affiliation>University of Alberta Hospital, Edmonton, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of Alberta Hospital, Edmonton</wicri:regionArea><wicri:noRegion>Edmonton</wicri:noRegion></affiliation></author><author><name sortKey="Thuluvath, Paul J" sort="Thuluvath, Paul J" uniqKey="Thuluvath P" first="Paul J" last="Thuluvath">Paul J. Thuluvath</name><affiliation wicri:level="2"><nlm:affiliation>Mercy Medical Center, Baltimore, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mercy Medical Center, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Tatum, Harvey A" sort="Tatum, Harvey A" uniqKey="Tatum H" first="Harvey A" last="Tatum">Harvey A. Tatum</name><affiliation wicri:level="2"><nlm:affiliation>Options Health Research, LLC, Tulsa, Oklahoma, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Options Health Research, LLC, Tulsa, Oklahoma</wicri:regionArea><placeName><region type="state">Oklahoma</region></placeName></affiliation></author><author><name sortKey="Waked, Imam" sort="Waked, Imam" uniqKey="Waked I" first="Imam" last="Waked">Imam Waked</name><affiliation wicri:level="1"><nlm:affiliation>National Liver Institute, Shebin Elkom, Egypt.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>National Liver Institute, Shebin Elkom</wicri:regionArea><wicri:noRegion>Shebin Elkom</wicri:noRegion></affiliation></author><author><name sortKey="Esmat, Gamal" sort="Esmat, Gamal" uniqKey="Esmat G" first="Gamal" last="Esmat">Gamal Esmat</name><affiliation wicri:level="1"><nlm:affiliation>Endemic Medicine and Hepatogastroenterology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Endemic Medicine and Hepatogastroenterology Department, Faculty of Medicine, Cairo University, Cairo</wicri:regionArea><wicri:noRegion>Cairo</wicri:noRegion></affiliation></author><author><name sortKey="Lawitz, Eric J" sort="Lawitz, Eric J" uniqKey="Lawitz E" first="Eric J" last="Lawitz">Eric J. Lawitz</name><affiliation wicri:level="2"><nlm:affiliation>Texas Liver Institute, University of Texas Health Science Center, San Antonio, Texas, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Texas Liver Institute, University of Texas Health Science Center, San Antonio, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Rustgi, Vinod K" sort="Rustgi, Vinod K" uniqKey="Rustgi V" first="Vinod K" last="Rustgi">Vinod K. Rustgi</name><affiliation wicri:level="2"><nlm:affiliation>Metropolitan Research, Fairfax, Virginia, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Metropolitan Research, Fairfax, Virginia</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Pol, Stanislas" sort="Pol, Stanislas" uniqKey="Pol S" first="Stanislas" last="Pol">Stanislas Pol</name><affiliation wicri:level="4"><nlm:affiliation>Inserm U1016 and Liver Unit, Université Paris Descartes, Hôpital Cochin, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm U1016 and Liver Unit, Université Paris Descartes, Hôpital Cochin, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Weis, Nina" sort="Weis, Nina" uniqKey="Weis N" first="Nina" last="Weis">Nina Weis</name><affiliation wicri:level="1"><nlm:affiliation>Copenhagen University Hospital, Hvidovre, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Copenhagen University Hospital, Hvidovre</wicri:regionArea><wicri:noRegion>Hvidovre</wicri:noRegion></affiliation></author><author><name sortKey="Pockros, Paul J" sort="Pockros, Paul J" uniqKey="Pockros P" first="Paul J" last="Pockros">Paul J. Pockros</name><affiliation wicri:level="2"><nlm:affiliation>Scripps Clinic, La Jolla, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Scripps Clinic, La Jolla, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Bourliere, Marc" sort="Bourliere, Marc" uniqKey="Bourliere M" first="Marc" last="Bourlière">Marc Bourlière</name><affiliation wicri:level="3"><nlm:affiliation>Hôpital Saint Joseph, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Saint Joseph, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Serfaty, Lawrence" sort="Serfaty, Lawrence" uniqKey="Serfaty L" first="Lawrence" last="Serfaty">Lawrence Serfaty</name><affiliation wicri:level="3"><nlm:affiliation>Hôpital Saint-Antoine, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Saint-Antoine, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Vierling, John M" sort="Vierling, John M" uniqKey="Vierling J" first="John M" last="Vierling">John M. Vierling</name><affiliation wicri:level="2"><nlm:affiliation>Baylor College of Medicine, Houston, Texas, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Baylor College of Medicine, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Fried, Michael W" sort="Fried, Michael W" uniqKey="Fried M" first="Michael W" last="Fried">Michael W. Fried</name><affiliation wicri:level="2"><nlm:affiliation>University of North Carolina, Chapel Hill, North Carolina, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of North Carolina, Chapel Hill, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Weiland, Ola" sort="Weiland, Ola" uniqKey="Weiland O" first="Ola" last="Weiland">Ola Weiland</name><affiliation wicri:level="3"><nlm:affiliation>Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Brunetto, Maurizia R" sort="Brunetto, Maurizia R" uniqKey="Brunetto M" first="Maurizia R" last="Brunetto">Maurizia R. Brunetto</name><affiliation wicri:level="3"><nlm:affiliation>Hepatology Unit, University Hospital of Pisa, Pisa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Hepatology Unit, University Hospital of Pisa, Pisa</wicri:regionArea><placeName><settlement type="city">Pise</settlement><region nuts="2">Toscane</region></placeName></affiliation></author><author><name sortKey="Everson, Gregory T" sort="Everson, Gregory T" uniqKey="Everson G" first="Gregory T" last="Everson">Gregory T. Everson</name><affiliation wicri:level="2"><nlm:affiliation>University of Colorado Denver, Aurora, Colorado, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Colorado Denver, Aurora, Colorado</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Zeuzem, Stefan" sort="Zeuzem, Stefan" uniqKey="Zeuzem S" first="Stefan" last="Zeuzem">Stefan Zeuzem</name><affiliation wicri:level="3"><nlm:affiliation>Goethe University, Frankfurt, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Goethe University, Frankfurt</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Kwo, Paul Y" sort="Kwo, Paul Y" uniqKey="Kwo P" first="Paul Y" last="Kwo">Paul Y. Kwo</name><affiliation wicri:level="2"><nlm:affiliation>Indiana University, Indianapolis, Indiana, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Indiana University, Indianapolis, Indiana</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Sulkowski, Mark" sort="Sulkowski, Mark" uniqKey="Sulkowski M" first="Mark" last="Sulkowski">Mark Sulkowski</name><affiliation wicri:level="2"><nlm:affiliation>Johns Hopkins University, Baltimore, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Johns Hopkins University, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Br U, Norbert" sort="Br U, Norbert" uniqKey="Br U N" first="Norbert" last="Br U">Norbert Br U</name><affiliation wicri:level="2"><nlm:affiliation>James J. Peters VA Medical Center, Bronx, New York, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>James J. Peters VA Medical Center, Bronx, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Hernandez, Dennis" sort="Hernandez, Dennis" uniqKey="Hernandez D" first="Dennis" last="Hernandez">Dennis Hernandez</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb, Clinical Research and Development, Wallingford, Connecticut, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb, Clinical Research and Development, Wallingford, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Mcphee, Fiona" sort="Mcphee, Fiona" uniqKey="Mcphee F" first="Fiona" last="Mcphee">Fiona Mcphee</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb, Clinical Research and Development, Wallingford, Connecticut, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb, Clinical Research and Development, Wallingford, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Wind Rotolo, Megan" sort="Wind Rotolo, Megan" uniqKey="Wind Rotolo M" first="Megan" last="Wind-Rotolo">Megan Wind-Rotolo</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb, Research and Development, Princeton, New Jersey, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb, Research and Development, Princeton, New Jersey</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Liu, Zhaohui" sort="Liu, Zhaohui" uniqKey="Liu Z" first="Zhaohui" last="Liu">Zhaohui Liu</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb Research and Development, Hopewell, New Jersey, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb Research and Development, Hopewell, New Jersey</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Noviello, Stephanie" sort="Noviello, Stephanie" uniqKey="Noviello S" first="Stephanie" last="Noviello">Stephanie Noviello</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb, Research and Development, Princeton, New Jersey, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb, Research and Development, Princeton, New Jersey</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Hughes, Eric A" sort="Hughes, Eric A" uniqKey="Hughes E" first="Eric A" last="Hughes">Eric A. Hughes</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb, Research and Development, Princeton, New Jersey, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb, Research and Development, Princeton, New Jersey</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Yin, Philip D" sort="Yin, Philip D" uniqKey="Yin P" first="Philip D" last="Yin">Philip D. Yin</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb, Clinical Research and Development, Wallingford, Connecticut, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb, Clinical Research and Development, Wallingford, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Schnittman, Steven" sort="Schnittman, Steven" uniqKey="Schnittman S" first="Steven" last="Schnittman">Steven Schnittman</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb, Clinical Research and Development, Wallingford, Connecticut, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb, Clinical Research and Development, Wallingford, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author></analytic><series><title level="j">Gut</title><idno type="eISSN">1468-3288</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Double-Blind Method</term><term>Drug Administration Schedule</term><term>Drug Therapy, Combination</term><term>Female</term><term>Genotype</term><term>Hepatitis C, Chronic (classification)</term><term>Hepatitis C, Chronic (drug therapy)</term><term>Hepatitis C, Chronic (genetics)</term><term>Hepatitis C, Chronic (virology)</term><term>Humans</term><term>Imidazoles (administration & dosage)</term><term>Interferon-alpha (administration & dosage)</term><term>Male</term><term>Middle Aged</term><term>Polyethylene Glycols (administration & dosage)</term><term>Recombinant Proteins (administration & dosage)</term><term>Remission Induction</term><term>Ribavirin (administration & dosage)</term><term>Treatment Outcome</term><term>Viral Load (drug effects)</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Association de médicaments</term><term>Calendrier d'administration des médicaments</term><term>Charge virale ()</term><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Hépatite C chronique ()</term><term>Hépatite C chronique (génétique)</term><term>Hépatite C chronique (traitement médicamenteux)</term><term>Hépatite C chronique (virologie)</term><term>Imidazoles (administration et posologie)</term><term>Induction de rémission</term><term>Interféron alpha (administration et posologie)</term><term>Jeune adulte</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Polyéthylène glycols (administration et posologie)</term><term>Protéines recombinantes (administration et posologie)</term><term>Ribavirine (administration et posologie)</term><term>Résultat thérapeutique</term><term>Sujet âgé</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Imidazoles</term><term>Interferon-alpha</term><term>Polyethylene Glycols</term><term>Recombinant Proteins</term><term>Ribavirin</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Imidazoles</term><term>Interféron alpha</term><term>Polyéthylène glycols</term><term>Protéines recombinantes</term><term>Ribavirine</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Hepatitis C, Chronic</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Viral Load</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Hepatitis C, Chronic</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Hepatitis C, Chronic</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Hépatite C chronique</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Hépatite C chronique</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Hépatite C chronique</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Hepatitis C, Chronic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Double-Blind Method</term><term>Drug Administration Schedule</term><term>Drug Therapy, Combination</term><term>Female</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Remission Induction</term><term>Treatment Outcome</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Association de médicaments</term><term>Calendrier d'administration des médicaments</term><term>Charge virale</term><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Hépatite C chronique</term><term>Induction de rémission</term><term>Jeune adulte</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Résultat thérapeutique</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To evaluate the safety and efficacy of daclatasvir, an HCV NS5A inhibitor with pangenotypic activity, administered with peginterferon-alfa-2a/ribavirin.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25080450</PMID><DateCreated><Year>2015</Year><Month>05</Month><Day>09</Day></DateCreated><DateCompleted><Year>2015</Year><Month>07</Month><Day>22</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1468-3288</ISSN><JournalIssue CitedMedium="Internet"><Volume>64</Volume><Issue>6</Issue><PubDate><Year>2015</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Gut</Title><ISOAbbreviation>Gut</ISOAbbreviation></Journal><ArticleTitle>Daclatasvir plus peginterferon alfa and ribavirin for treatment-naive chronic hepatitis C genotype 1 or 4 infection: a randomised study.</ArticleTitle><Pagination><MedlinePgn>948-56</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1136/gutjnl-2014-307498</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To evaluate the safety and efficacy of daclatasvir, an HCV NS5A inhibitor with pangenotypic activity, administered with peginterferon-alfa-2a/ribavirin.</AbstractText><AbstractText Label="DESIGN" NlmCategory="METHODS">In this Phase 2b double-blind, placebo-controlled study, treatment-naive adults with HCV genotype 1 (N=365) or 4 (N=30) infection were randomly assigned (2:2:1) to daclatasvir 20 mg or 60 mg, or placebo once daily plus weekly peginterferon-alfa-2a and twice-daily ribavirin. Daclatasvir recipients achieving protocol-defined response (PDR; HCV-RNA</AbstractText> <AbstractText Label="RESULTS" NlmCategory="RESULTS">Overall, eRVR was achieved by 54.4% (80/147) of genotype 1-infected patients receiving daclatasvir 20 mg, 54.1% (79/146) receiving 60 mg versus 13.9% (10/72) receiving placebo. SVR24 was achieved among 87 (59.2%), 87 (59.6%), and 27 (37.5%) patients in these groups, respectively. Higher proportions of genotype 4-infected patients receiving daclatasvir 20 mg (66.7%; 8/12) or 60 mg (100.0%; 12/12) achieved SVR24 versus placebo (50.0%; 3/6). A majority of daclatasvir-treated patients achieved PDR and experienced less virologic failure and higher SVR24 rates with a shortened 24-week treatment duration. Adverse events occurred with similar frequency across all treatment groups.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The combination of daclatasvir/peginterferon-alfa/ribavirin was generally well tolerated and achieved higher SVR24 rates compared with placebo/peginterferon-alfa/ribavirin among patients infected with HCV genotype 1 or 4.</AbstractText><AbstractText Label="TRIAL REGISTRATION NUMBER" NlmCategory="BACKGROUND">NCT01125189.</AbstractText><CopyrightInformation>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hézode</LastName><ForeName>Christophe</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Hôpital Henri Mondor, AP-HP, Université Paris-Est, Inserm U955, Créteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hirschfield</LastName><ForeName>Gideon M</ForeName><Initials>GM</Initials><AffiliationInfo><Affiliation>Centre for Liver Research and NIHR Biomedical Research Unit, University of Birmingham, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ghesquiere</LastName><ForeName>Wayne</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Vancouver Island Health Authority & University of British Columbia, Victoria, British Columbia, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sievert</LastName><ForeName>William</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Monash University and Monash Health, Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rodriguez-Torres</LastName><ForeName>Maribel</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Fundacion De Investigacion, San Juan Bautista School of Medicine, San Juan, Puerto Rico.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shafran</LastName><ForeName>Stephen D</ForeName><Initials>SD</Initials><AffiliationInfo><Affiliation>University of Alberta Hospital, Edmonton, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thuluvath</LastName><ForeName>Paul J</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>Mercy Medical Center, Baltimore, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tatum</LastName><ForeName>Harvey A</ForeName><Initials>HA</Initials><AffiliationInfo><Affiliation>Options Health Research, LLC, Tulsa, Oklahoma, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Waked</LastName><ForeName>Imam</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>National Liver Institute, Shebin Elkom, Egypt.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Esmat</LastName><ForeName>Gamal</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Endemic Medicine and Hepatogastroenterology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lawitz</LastName><ForeName>Eric J</ForeName><Initials>EJ</Initials><AffiliationInfo><Affiliation>Texas Liver Institute, University of Texas Health Science Center, San Antonio, Texas, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rustgi</LastName><ForeName>Vinod K</ForeName><Initials>VK</Initials><AffiliationInfo><Affiliation>Metropolitan Research, Fairfax, Virginia, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pol</LastName><ForeName>Stanislas</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Inserm U1016 and Liver Unit, Université Paris Descartes, Hôpital Cochin, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weis</LastName><ForeName>Nina</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Copenhagen University Hospital, Hvidovre, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pockros</LastName><ForeName>Paul J</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>Scripps Clinic, La Jolla, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bourlière</LastName><ForeName>Marc</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Hôpital Saint Joseph, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Serfaty</LastName><ForeName>Lawrence</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Hôpital Saint-Antoine, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vierling</LastName><ForeName>John M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Baylor College of Medicine, Houston, Texas, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fried</LastName><ForeName>Michael W</ForeName><Initials>MW</Initials><AffiliationInfo><Affiliation>University of North Carolina, Chapel Hill, North Carolina, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weiland</LastName><ForeName>Ola</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brunetto</LastName><ForeName>Maurizia R</ForeName><Initials>MR</Initials><AffiliationInfo><Affiliation>Hepatology Unit, University Hospital of Pisa, Pisa, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Everson</LastName><ForeName>Gregory T</ForeName><Initials>GT</Initials><AffiliationInfo><Affiliation>University of Colorado Denver, Aurora, Colorado, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zeuzem</LastName><ForeName>Stefan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Goethe University, Frankfurt, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kwo</LastName><ForeName>Paul Y</ForeName><Initials>PY</Initials><AffiliationInfo><Affiliation>Indiana University, Indianapolis, Indiana, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sulkowski</LastName><ForeName>Mark</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Johns Hopkins University, Baltimore, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bräu</LastName><ForeName>Norbert</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>James J. Peters VA Medical Center, Bronx, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hernandez</LastName><ForeName>Dennis</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Bristol-Myers Squibb, Clinical Research and Development, Wallingford, Connecticut, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McPhee</LastName><ForeName>Fiona</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Bristol-Myers Squibb, Clinical Research and Development, Wallingford, Connecticut, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wind-Rotolo</LastName><ForeName>Megan</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Bristol-Myers Squibb, Research and Development, Princeton, New Jersey, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Zhaohui</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Bristol-Myers Squibb Research and Development, Hopewell, New Jersey, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Noviello</LastName><ForeName>Stephanie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Bristol-Myers Squibb, Research and Development, Princeton, New Jersey, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hughes</LastName><ForeName>Eric A</ForeName><Initials>EA</Initials><AffiliationInfo><Affiliation>Bristol-Myers Squibb, Research and Development, Princeton, New Jersey, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yin</LastName><ForeName>Philip D</ForeName><Initials>PD</Initials><AffiliationInfo><Affiliation>Bristol-Myers Squibb, Clinical Research and Development, Wallingford, Connecticut, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schnittman</LastName><ForeName>Steven</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Bristol-Myers Squibb, Clinical Research and Development, Wallingford, Connecticut, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT01125189</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D017427">Clinical Trial, Phase II</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>07</Month><Day>30</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Gut</MedlineTA><NlmUniqueID>2985108R</NlmUniqueID><ISSNLinking>0017-5749</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C549273">BMS-790052</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007093">Imidazoles</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016898">Interferon-alpha</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011994">Recombinant Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>30IQX730WE</RegistryNumber><NameOfSubstance UI="D011092">Polyethylene Glycols</NameOfSubstance></Chemical><Chemical><RegistryNumber>49717AWG6K</RegistryNumber><NameOfSubstance UI="D012254">Ribavirin</NameOfSubstance></Chemical><Chemical><RegistryNumber>Q46947FE7K</RegistryNumber><NameOfSubstance UI="C100416">peginterferon alfa-2a</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004311" MajorTopicYN="N">Double-Blind Method</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004334" MajorTopicYN="N">Drug Administration Schedule</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004359" MajorTopicYN="N">Drug Therapy, Combination</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005838" MajorTopicYN="N">Genotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019698" MajorTopicYN="N">Hepatitis C, Chronic</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007093" MajorTopicYN="N">Imidazoles</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016898" MajorTopicYN="N">Interferon-alpha</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011092" MajorTopicYN="N">Polyethylene Glycols</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011994" MajorTopicYN="N">Recombinant Proteins</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012074" MajorTopicYN="N">Remission Induction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012254" MajorTopicYN="N">Ribavirin</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019562" MajorTopicYN="N">Viral Load</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>04</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>07</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>8</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>8</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>7</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25080450</ArticleId><ArticleId IdType="pii">gutjnl-2014-307498</ArticleId><ArticleId IdType="doi">10.1136/gutjnl-2014-307498</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>Danemark</li><li>France</li><li>Italie</li><li>Porto Rico</li><li>Royaume-Uni</li><li>Suède</li><li>Égypte</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Californie</li><li>Caroline du Nord</li><li>Colorado</li><li>Connecticut</li><li>District de Darmstadt</li><li>Hesse (Land)</li><li>Indiana</li><li>Maryland</li><li>Midlands de l'Ouest</li><li>New Jersey</li><li>Oklahoma</li><li>Provence-Alpes-Côte d'Azur</li><li>Svealand</li><li>Texas</li><li>Toscane</li><li>Victoria (État)</li><li>Virginie</li><li>État de New York</li><li>Île-de-France</li></region><settlement><li>Birmingham</li><li>Créteil</li><li>Francfort-sur-le-Main</li><li>Marseille</li><li>Melbourne</li><li>Paris</li><li>Pise</li><li>Stockholm</li></settlement><orgName><li>Université Paris-Descartes</li><li>Université de Birmingham</li></orgName></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Hezode, Christophe" sort="Hezode, Christophe" uniqKey="Hezode C" first="Christophe" last="Hézode">Christophe Hézode</name></region><name sortKey="Bourliere, Marc" sort="Bourliere, Marc" uniqKey="Bourliere M" first="Marc" last="Bourlière">Marc Bourlière</name><name sortKey="Pol, Stanislas" sort="Pol, Stanislas" uniqKey="Pol S" first="Stanislas" last="Pol">Stanislas Pol</name><name sortKey="Serfaty, Lawrence" sort="Serfaty, Lawrence" uniqKey="Serfaty L" first="Lawrence" last="Serfaty">Lawrence Serfaty</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Hirschfield, Gideon M" sort="Hirschfield, Gideon M" uniqKey="Hirschfield G" first="Gideon M" last="Hirschfield">Gideon M. Hirschfield</name></region></country><country name="Canada"><noRegion><name sortKey="Ghesquiere, Wayne" sort="Ghesquiere, Wayne" uniqKey="Ghesquiere W" first="Wayne" last="Ghesquiere">Wayne Ghesquiere</name></noRegion><name sortKey="Shafran, Stephen D" sort="Shafran, Stephen D" uniqKey="Shafran S" first="Stephen D" last="Shafran">Stephen D. Shafran</name></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Sievert, William" sort="Sievert, William" uniqKey="Sievert W" first="William" last="Sievert">William Sievert</name></region></country><country name="Porto Rico"><noRegion><name sortKey="Rodriguez Torres, Maribel" sort="Rodriguez Torres, Maribel" uniqKey="Rodriguez Torres M" first="Maribel" last="Rodriguez-Torres">Maribel Rodriguez-Torres</name></noRegion></country><country name="États-Unis"><region name="Maryland"><name sortKey="Thuluvath, Paul J" sort="Thuluvath, Paul J" uniqKey="Thuluvath P" first="Paul J" last="Thuluvath">Paul J. Thuluvath</name></region><name sortKey="Br U, Norbert" sort="Br U, Norbert" uniqKey="Br U N" first="Norbert" last="Br U">Norbert Br U</name><name sortKey="Everson, Gregory T" sort="Everson, Gregory T" uniqKey="Everson G" first="Gregory T" last="Everson">Gregory T. Everson</name><name sortKey="Fried, Michael W" sort="Fried, Michael W" uniqKey="Fried M" first="Michael W" last="Fried">Michael W. Fried</name><name sortKey="Hernandez, Dennis" sort="Hernandez, Dennis" uniqKey="Hernandez D" first="Dennis" last="Hernandez">Dennis Hernandez</name><name sortKey="Hughes, Eric A" sort="Hughes, Eric A" uniqKey="Hughes E" first="Eric A" last="Hughes">Eric A. Hughes</name><name sortKey="Kwo, Paul Y" sort="Kwo, Paul Y" uniqKey="Kwo P" first="Paul Y" last="Kwo">Paul Y. Kwo</name><name sortKey="Lawitz, Eric J" sort="Lawitz, Eric J" uniqKey="Lawitz E" first="Eric J" last="Lawitz">Eric J. Lawitz</name><name sortKey="Liu, Zhaohui" sort="Liu, Zhaohui" uniqKey="Liu Z" first="Zhaohui" last="Liu">Zhaohui Liu</name><name sortKey="Mcphee, Fiona" sort="Mcphee, Fiona" uniqKey="Mcphee F" first="Fiona" last="Mcphee">Fiona Mcphee</name><name sortKey="Noviello, Stephanie" sort="Noviello, Stephanie" uniqKey="Noviello S" first="Stephanie" last="Noviello">Stephanie Noviello</name><name sortKey="Pockros, Paul J" sort="Pockros, Paul J" uniqKey="Pockros P" first="Paul J" last="Pockros">Paul J. Pockros</name><name sortKey="Rustgi, Vinod K" sort="Rustgi, Vinod K" uniqKey="Rustgi V" first="Vinod K" last="Rustgi">Vinod K. Rustgi</name><name sortKey="Schnittman, Steven" sort="Schnittman, Steven" uniqKey="Schnittman S" first="Steven" last="Schnittman">Steven Schnittman</name><name sortKey="Sulkowski, Mark" sort="Sulkowski, Mark" uniqKey="Sulkowski M" first="Mark" last="Sulkowski">Mark Sulkowski</name><name sortKey="Tatum, Harvey A" sort="Tatum, Harvey A" uniqKey="Tatum H" first="Harvey A" last="Tatum">Harvey A. Tatum</name><name sortKey="Vierling, John M" sort="Vierling, John M" uniqKey="Vierling J" first="John M" last="Vierling">John M. Vierling</name><name sortKey="Wind Rotolo, Megan" sort="Wind Rotolo, Megan" uniqKey="Wind Rotolo M" first="Megan" last="Wind-Rotolo">Megan Wind-Rotolo</name><name sortKey="Yin, Philip D" sort="Yin, Philip D" uniqKey="Yin P" first="Philip D" last="Yin">Philip D. Yin</name></country><country name="Égypte"><noRegion><name sortKey="Waked, Imam" sort="Waked, Imam" uniqKey="Waked I" first="Imam" last="Waked">Imam Waked</name></noRegion><name sortKey="Esmat, Gamal" sort="Esmat, Gamal" uniqKey="Esmat G" first="Gamal" last="Esmat">Gamal Esmat</name></country><country name="Danemark"><noRegion><name sortKey="Weis, Nina" sort="Weis, Nina" uniqKey="Weis N" first="Nina" last="Weis">Nina Weis</name></noRegion></country><country name="Suède"><region name="Svealand"><name sortKey="Weiland, Ola" sort="Weiland, Ola" uniqKey="Weiland O" first="Ola" last="Weiland">Ola Weiland</name></region></country><country name="Italie"><region name="Toscane"><name sortKey="Brunetto, Maurizia R" sort="Brunetto, Maurizia R" uniqKey="Brunetto M" first="Maurizia R" last="Brunetto">Maurizia R. Brunetto</name></region></country><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Zeuzem, Stefan" sort="Zeuzem, Stefan" uniqKey="Zeuzem S" first="Stefan" last="Zeuzem">Stefan Zeuzem</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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