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Der p 11 is a major allergen for house dust mite-allergic patients suffering from atopic dermatitis.

Identifieur interne : 002D38 ( PubMed/Checkpoint ); précédent : 002D37; suivant : 002D39

Der p 11 is a major allergen for house dust mite-allergic patients suffering from atopic dermatitis.

Auteurs : Srinita Banerjee [Autriche] ; Yvonne Resch [Autriche] ; Kuan-Wei Chen [Autriche] ; Ines Swoboda [Autriche] ; Margit Focke-Tejkl [Autriche] ; Katharina Blatt [Autriche] ; Natalija Novak [Allemagne] ; Magnus Wickman [Suède] ; Marianne Van Hage [Suède] ; Rosetta Ferrara [Italie] ; Adriano Mari [Italie] ; Ashok Purohit [France] ; Gabrielle Pauli [France] ; Elopy N. Sibanda [Zimbabwe] ; Portia Ndlovu [Zimbabwe] ; Wayne R. Thomas [Australie] ; Vladislav Krzyzanek [République tchèque] ; Sebastian Tacke [Allemagne] ; Ursula Malkus [Allemagne] ; Peter Valent [Autriche] ; Rudolf Valenta [Autriche] ; Susanne Vrtala [Autriche]

Source :

The Journal of investigative dermatology [ 1523-1747 ] ; 2015.

RBID : pubmed:24999597

Descripteurs français

English descriptors

KwdEn :
- Adolescent, Adult, Amino Acid Sequence, Animals, Antibodies (blood), Antibodies (immunology), Antigens, Dermatophagoides (chemistry), Antigens, Dermatophagoides (genetics), Antigens, Dermatophagoides (immunology), Arthropod Proteins, Biomarkers, Child, Circular Dichroism, Dermatitis, Atopic (epidemiology), Dermatitis, Atopic (immunology), Dermatophagoides pteronyssinus (genetics), Dermatophagoides pteronyssinus (immunology), Female, Humans, Immunoglobulin E (blood), Immunoglobulin E (immunology), Male, Molecular Sequence Data, Protein Structure, Secondary, Seroepidemiologic Studies, Tropomyosin (chemistry), Tropomyosin (genetics), Tropomyosin (immunology), Young Adult.
MESH :
- chemical , blood : Antibodies, Immunoglobulin E.
- chemical , chemistry : Antigens, Dermatophagoides, Tropomyosin.
- chemical , genetics : Antigens, Dermatophagoides, Tropomyosin.
- chemical , immunology : Antibodies, Antigens, Dermatophagoides, Immunoglobulin E, Tropomyosin.
- epidemiology : Dermatitis, Atopic.
- genetics : Dermatophagoides pteronyssinus.
- immunology : Dermatitis, Atopic, Dermatophagoides pteronyssinus.
- Adolescent, Adult, Amino Acid Sequence, Animals, Arthropod Proteins, Biomarkers, Child, Circular Dichroism, Female, Humans, Male, Molecular Sequence Data, Protein Structure, Secondary, Seroepidemiologic Studies, Young Adult.

Abstract

House dust mites (HDMs) belong to the most potent indoor allergen sources worldwide and are associated with allergic manifestations in the respiratory tract and the skin. Here we studied the importance of the high-molecular-weight group 11 allergen from Dermatophagoides pteronyssinus (Der p 11) in HDM allergy. Sequence analysis showed that Der p 11 has high homology to paramyosins from mites, ticks, and other invertebrates. A synthetic gene coding for Der p 11 was expressed in Escherichia coli and rDer p 11 purified to homogeneity as folded, alpha-helical protein as determined by circular dichroism spectroscopy. Using antibodies raised against rDer p 11 and immunogold electron microscopy, the allergen was localized in the muscle beneath the skin of mite bodies but not in feces. IgE reactivity of rDer p 11 was tested with sera from HDM-allergic patients from Europe and Africa in radioallergosorbent test-based dot-blot assays. Interestingly, we found that Der p 11 is a major allergen for patients suffering from atopic dermatitis (AD), whereas it is only a minor allergen for patients suffering from respiratory forms of HDM allergy. Thus, rDer p 11 might be a useful serological marker allergen for the identification of a subgroup of HDM-allergic patients suffering from HDM-associated AD.

DOI: 10.1038/jid.2014.271
PubMed: 24999597

Affiliations:

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<author><name sortKey="Swoboda, Ines" sort="Swoboda, Ines" uniqKey="Swoboda I" first="Ines" last="Swoboda">Ines Swoboda</name>
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<author><name sortKey="Blatt, Katharina" sort="Blatt, Katharina" uniqKey="Blatt K" first="Katharina" last="Blatt">Katharina Blatt</name>
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<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna</wicri:regionArea>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
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<author><name sortKey="Novak, Natalija" sort="Novak, Natalija" uniqKey="Novak N" first="Natalija" last="Novak">Natalija Novak</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology and Allergy, University of Bonn, Bonn, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Dermatology and Allergy, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
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</author>
<author><name sortKey="Wickman, Magnus" sort="Wickman, Magnus" uniqKey="Wickman M" first="Magnus" last="Wickman">Magnus Wickman</name>
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<country xml:lang="fr">Suède</country>
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<country xml:lang="fr">Suède</country>
<wicri:regionArea>Clinical Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institutet and University Hospital Stockholm, Stockholm</wicri:regionArea>
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<author><name sortKey="Ferrara, Rosetta" sort="Ferrara, Rosetta" uniqKey="Ferrara R" first="Rosetta" last="Ferrara">Rosetta Ferrara</name>
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<country xml:lang="fr">Italie</country>
<wicri:regionArea>Center for Molecular Allergology, IDI-IRCCS, Rome</wicri:regionArea>
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</placeName>
</affiliation>
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<author><name sortKey="Mari, Adriano" sort="Mari, Adriano" uniqKey="Mari A" first="Adriano" last="Mari">Adriano Mari</name>
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<country xml:lang="fr">Italie</country>
<wicri:regionArea>Center for Molecular Allergology, IDI-IRCCS, Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Purohit, Ashok" sort="Purohit, Ashok" uniqKey="Purohit A" first="Ashok" last="Purohit">Ashok Purohit</name>
<affiliation wicri:level="3"><nlm:affiliation>Service de Pneumologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Pneumologie, Hôpitaux Universitaires de Strasbourg, Strasbourg</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pauli, Gabrielle" sort="Pauli, Gabrielle" uniqKey="Pauli G" first="Gabrielle" last="Pauli">Gabrielle Pauli</name>
<affiliation wicri:level="3"><nlm:affiliation>Service de Pneumologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Pneumologie, Hôpitaux Universitaires de Strasbourg, Strasbourg</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sibanda, Elopy N" sort="Sibanda, Elopy N" uniqKey="Sibanda E" first="Elopy N" last="Sibanda">Elopy N. Sibanda</name>
<affiliation wicri:level="1"><nlm:affiliation>Gamma City Laboratory, Harare, Zimbabwe.</nlm:affiliation>
<country xml:lang="fr">Zimbabwe</country>
<wicri:regionArea>Gamma City Laboratory, Harare</wicri:regionArea>
<wicri:noRegion>Harare</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ndlovu, Portia" sort="Ndlovu, Portia" uniqKey="Ndlovu P" first="Portia" last="Ndlovu">Portia Ndlovu</name>
<affiliation wicri:level="1"><nlm:affiliation>Gamma City Laboratory, Harare, Zimbabwe.</nlm:affiliation>
<country xml:lang="fr">Zimbabwe</country>
<wicri:regionArea>Gamma City Laboratory, Harare</wicri:regionArea>
<wicri:noRegion>Harare</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Thomas, Wayne R" sort="Thomas, Wayne R" uniqKey="Thomas W" first="Wayne R" last="Thomas">Wayne R. Thomas</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Child Health Research, Telethon Institute of Child Health Research, University of Western Australia, Perth, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Center for Child Health Research, Telethon Institute of Child Health Research, University of Western Australia, Perth</wicri:regionArea>
<wicri:noRegion>Perth</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Krzyzanek, Vladislav" sort="Krzyzanek, Vladislav" uniqKey="Krzyzanek V" first="Vladislav" last="Krzyzanek">Vladislav Krzyzanek</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Scientific Instruments, Academy of Sciences of the Czech Republic, Brno, Czech Republic.</nlm:affiliation>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea>Institute of Scientific Instruments, Academy of Sciences of the Czech Republic, Brno</wicri:regionArea>
<placeName><settlement type="city">Brno</settlement>
<region>Moravie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tacke, Sebastian" sort="Tacke, Sebastian" uniqKey="Tacke S" first="Sebastian" last="Tacke">Sebastian Tacke</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Medical Physics and Biophysics, University of Münster, Münster, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Medical Physics and Biophysics, University of Münster, Münster</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Münster</region>
<settlement type="city">Münster</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Malkus, Ursula" sort="Malkus, Ursula" uniqKey="Malkus U" first="Ursula" last="Malkus">Ursula Malkus</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Medical Physics and Biophysics, University of Münster, Münster, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Medical Physics and Biophysics, University of Münster, Münster</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Münster</region>
<settlement type="city">Münster</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Valent, Peter" sort="Valent, Peter" uniqKey="Valent P" first="Peter" last="Valent">Peter Valent</name>
<affiliation wicri:level="3"><nlm:affiliation>Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna</wicri:regionArea>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Valenta, Rudolf" sort="Valenta, Rudolf" uniqKey="Valenta R" first="Rudolf" last="Valenta">Rudolf Valenta</name>
<affiliation wicri:level="3"><nlm:affiliation>Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria; Christian Doppler Laboratory for Allergy Research, Medical University of Vienna, Vienna, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria; Christian Doppler Laboratory for Allergy Research, Medical University of Vienna, Vienna</wicri:regionArea>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vrtala, Susanne" sort="Vrtala, Susanne" uniqKey="Vrtala S" first="Susanne" last="Vrtala">Susanne Vrtala</name>
<affiliation wicri:level="3"><nlm:affiliation>Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria; Christian Doppler Laboratory for the Development of Allergen Chips, Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria. Electronic address: susanne.vrtala@meduniwien.ac.at.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria; Christian Doppler Laboratory for the Development of Allergen Chips, Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna</wicri:regionArea>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of investigative dermatology</title>
<idno type="eISSN">1523-1747</idno>
<imprint><date when="2015" type="published">2015</date>
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<term>Adult</term>
<term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Antibodies (blood)</term>
<term>Antibodies (immunology)</term>
<term>Antigens, Dermatophagoides (chemistry)</term>
<term>Antigens, Dermatophagoides (genetics)</term>
<term>Antigens, Dermatophagoides (immunology)</term>
<term>Arthropod Proteins</term>
<term>Biomarkers</term>
<term>Child</term>
<term>Circular Dichroism</term>
<term>Dermatitis, Atopic (epidemiology)</term>
<term>Dermatitis, Atopic (immunology)</term>
<term>Dermatophagoides pteronyssinus (genetics)</term>
<term>Dermatophagoides pteronyssinus (immunology)</term>
<term>Female</term>
<term>Humans</term>
<term>Immunoglobulin E (blood)</term>
<term>Immunoglobulin E (immunology)</term>
<term>Male</term>
<term>Molecular Sequence Data</term>
<term>Protein Structure, Secondary</term>
<term>Seroepidemiologic Studies</term>
<term>Tropomyosin (chemistry)</term>
<term>Tropomyosin (genetics)</term>
<term>Tropomyosin (immunology)</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Animaux</term>
<term>Anticorps (immunologie)</term>
<term>Anticorps (sang)</term>
<term>Antigènes de Dermatophagoides ()</term>
<term>Antigènes de Dermatophagoides (génétique)</term>
<term>Antigènes de Dermatophagoides (immunologie)</term>
<term>Dermatophagoides pteronyssinus (génétique)</term>
<term>Dermatophagoides pteronyssinus (immunologie)</term>
<term>Dichroïsme circulaire</term>
<term>Données de séquences moléculaires</term>
<term>Eczéma atopique (immunologie)</term>
<term>Eczéma atopique (épidémiologie)</term>
<term>Enfant</term>
<term>Femelle</term>
<term>Humains</term>
<term>Immunoglobuline E (immunologie)</term>
<term>Immunoglobuline E (sang)</term>
<term>Jeune adulte</term>
<term>Marqueurs biologiques</term>
<term>Mâle</term>
<term>Protéines d'arthropode</term>
<term>Structure secondaire des protéines</term>
<term>Séquence d'acides aminés</term>
<term>Tropomyosine ()</term>
<term>Tropomyosine (génétique)</term>
<term>Tropomyosine (immunologie)</term>
<term>Études séroépidémiologiques</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies</term>
<term>Immunoglobulin E</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antigens, Dermatophagoides</term>
<term>Tropomyosin</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Antigens, Dermatophagoides</term>
<term>Tropomyosin</term>
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<term>Antigens, Dermatophagoides</term>
<term>Immunoglobulin E</term>
<term>Tropomyosin</term>
</keywords>
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</keywords>
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</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigènes de Dermatophagoides</term>
<term>Dermatophagoides pteronyssinus</term>
<term>Tropomyosine</term>
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<term>Antigènes de Dermatophagoides</term>
<term>Dermatophagoides pteronyssinus</term>
<term>Eczéma atopique</term>
<term>Immunoglobuline E</term>
<term>Tropomyosine</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Dermatitis, Atopic</term>
<term>Dermatophagoides pteronyssinus</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps</term>
<term>Immunoglobuline E</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Eczéma atopique</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Arthropod Proteins</term>
<term>Biomarkers</term>
<term>Child</term>
<term>Circular Dichroism</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Molecular Sequence Data</term>
<term>Protein Structure, Secondary</term>
<term>Seroepidemiologic Studies</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Animaux</term>
<term>Antigènes de Dermatophagoides</term>
<term>Dichroïsme circulaire</term>
<term>Données de séquences moléculaires</term>
<term>Enfant</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Marqueurs biologiques</term>
<term>Mâle</term>
<term>Protéines d'arthropode</term>
<term>Structure secondaire des protéines</term>
<term>Séquence d'acides aminés</term>
<term>Tropomyosine</term>
<term>Études séroépidémiologiques</term>
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<front><div type="abstract" xml:lang="en">House dust mites (HDMs) belong to the most potent indoor allergen sources worldwide and are associated with allergic manifestations in the respiratory tract and the skin. Here we studied the importance of the high-molecular-weight group 11 allergen from Dermatophagoides pteronyssinus (Der p 11) in HDM allergy. Sequence analysis showed that Der p 11 has high homology to paramyosins from mites, ticks, and other invertebrates. A synthetic gene coding for Der p 11 was expressed in Escherichia coli and rDer p 11 purified to homogeneity as folded, alpha-helical protein as determined by circular dichroism spectroscopy. Using antibodies raised against rDer p 11 and immunogold electron microscopy, the allergen was localized in the muscle beneath the skin of mite bodies but not in feces. IgE reactivity of rDer p 11 was tested with sera from HDM-allergic patients from Europe and Africa in radioallergosorbent test-based dot-blot assays. Interestingly, we found that Der p 11 is a major allergen for patients suffering from atopic dermatitis (AD), whereas it is only a minor allergen for patients suffering from respiratory forms of HDM allergy. Thus, rDer p 11 might be a useful serological marker allergen for the identification of a subgroup of HDM-allergic patients suffering from HDM-associated AD.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24999597</PMID>
<DateCreated><Year>2014</Year>
<Month>12</Month>
<Day>16</Day>
</DateCreated>
<DateCompleted><Year>2015</Year>
<Month>02</Month>
<Day>26</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>09</Month>
<Day>22</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1523-1747</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>135</Volume>
<Issue>1</Issue>
<PubDate><Year>2015</Year>
<Month>Jan</Month>
</PubDate>
</JournalIssue>
<Title>The Journal of investigative dermatology</Title>
<ISOAbbreviation>J. Invest. Dermatol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Der p 11 is a major allergen for house dust mite-allergic patients suffering from atopic dermatitis.</ArticleTitle>
<Pagination><MedlinePgn>102-109</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S0022-202X(15)37035-4</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1038/jid.2014.271</ELocationID>
<Abstract><AbstractText>House dust mites (HDMs) belong to the most potent indoor allergen sources worldwide and are associated with allergic manifestations in the respiratory tract and the skin. Here we studied the importance of the high-molecular-weight group 11 allergen from Dermatophagoides pteronyssinus (Der p 11) in HDM allergy. Sequence analysis showed that Der p 11 has high homology to paramyosins from mites, ticks, and other invertebrates. A synthetic gene coding for Der p 11 was expressed in Escherichia coli and rDer p 11 purified to homogeneity as folded, alpha-helical protein as determined by circular dichroism spectroscopy. Using antibodies raised against rDer p 11 and immunogold electron microscopy, the allergen was localized in the muscle beneath the skin of mite bodies but not in feces. IgE reactivity of rDer p 11 was tested with sera from HDM-allergic patients from Europe and Africa in radioallergosorbent test-based dot-blot assays. Interestingly, we found that Der p 11 is a major allergen for patients suffering from atopic dermatitis (AD), whereas it is only a minor allergen for patients suffering from respiratory forms of HDM allergy. Thus, rDer p 11 might be a useful serological marker allergen for the identification of a subgroup of HDM-allergic patients suffering from HDM-associated AD.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Banerjee</LastName>
<ForeName>Srinita</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Resch</LastName>
<ForeName>Yvonne</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Kuan-Wei</ForeName>
<Initials>KW</Initials>
<AffiliationInfo><Affiliation>Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Swoboda</LastName>
<ForeName>Ines</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria; Christian Doppler Laboratory for Allergy Research, Medical University of Vienna, Vienna, Austria.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Focke-Tejkl</LastName>
<ForeName>Margit</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Christian Doppler Laboratory for Allergy Research, Medical University of Vienna, Vienna, Austria.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Blatt</LastName>
<ForeName>Katharina</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Novak</LastName>
<ForeName>Natalija</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Department of Dermatology and Allergy, University of Bonn, Bonn, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wickman</LastName>
<ForeName>Magnus</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Sachs' Children's Hospital and Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>van Hage</LastName>
<ForeName>Marianne</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Clinical Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institutet and University Hospital Stockholm, Stockholm, Sweden.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ferrara</LastName>
<ForeName>Rosetta</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Center for Molecular Allergology, IDI-IRCCS, Rome, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mari</LastName>
<ForeName>Adriano</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Center for Molecular Allergology, IDI-IRCCS, Rome, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Purohit</LastName>
<ForeName>Ashok</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Service de Pneumologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pauli</LastName>
<ForeName>Gabrielle</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Service de Pneumologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sibanda</LastName>
<ForeName>Elopy N</ForeName>
<Initials>EN</Initials>
<AffiliationInfo><Affiliation>Gamma City Laboratory, Harare, Zimbabwe.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ndlovu</LastName>
<ForeName>Portia</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Gamma City Laboratory, Harare, Zimbabwe.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Thomas</LastName>
<ForeName>Wayne R</ForeName>
<Initials>WR</Initials>
<AffiliationInfo><Affiliation>Center for Child Health Research, Telethon Institute of Child Health Research, University of Western Australia, Perth, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Krzyzanek</LastName>
<ForeName>Vladislav</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Institute of Scientific Instruments, Academy of Sciences of the Czech Republic, Brno, Czech Republic.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tacke</LastName>
<ForeName>Sebastian</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Institute of Medical Physics and Biophysics, University of Münster, Münster, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Malkus</LastName>
<ForeName>Ursula</ForeName>
<Initials>U</Initials>
<AffiliationInfo><Affiliation>Institute of Medical Physics and Biophysics, University of Münster, Münster, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Valent</LastName>
<ForeName>Peter</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Valenta</LastName>
<ForeName>Rudolf</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria; Christian Doppler Laboratory for Allergy Research, Medical University of Vienna, Vienna, Austria.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Vrtala</LastName>
<ForeName>Susanne</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria; Christian Doppler Laboratory for the Development of Allergen Chips, Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria. Electronic address: susanne.vrtala@meduniwien.ac.at.</Affiliation>
</AffiliationInfo>
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<GrantList CompleteYN="Y"><Grant><GrantID>F 4602</GrantID>
<Agency>Austrian Science Fund FWF</Agency>
<Country>Austria</Country>
</Grant>
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<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2014</Year>
<Month>08</Month>
<Day>07</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Invest Dermatol</MedlineTA>
<NlmUniqueID>0426720</NlmUniqueID>
<ISSNLinking>0022-202X</ISSNLinking>
</MedlineJournalInfo>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
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<MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName>
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<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
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<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017433" MajorTopicYN="N">Protein Structure, Secondary</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016036" MajorTopicYN="N">Seroepidemiologic Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014335" MajorTopicYN="N">Tropomyosin</DescriptorName>
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<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<OtherID Source="NLM">EMS65213</OtherID>
<OtherID Source="NLM">PMC4636057</OtherID>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year>
<Month>02</Month>
<Day>10</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2014</Year>
<Month>05</Month>
<Day>23</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2014</Year>
<Month>06</Month>
<Day>04</Day>
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<PubMedPubDate PubStatus="entrez"><Year>2014</Year>
<Month>7</Month>
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<ArticleIdList><ArticleId IdType="pubmed">24999597</ArticleId>
<ArticleId IdType="pii">S0022-202X(15)37035-4</ArticleId>
<ArticleId IdType="doi">10.1038/jid.2014.271</ArticleId>
<ArticleId IdType="pmc">PMC4636057</ArticleId>
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</pubmed>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Autriche</li>
<li>France</li>
<li>Italie</li>
<li>République tchèque</li>
<li>Suède</li>
<li>Zimbabwe</li>
</country>
<region><li>Alsace (région administrative)</li>
<li>District de Cologne</li>
<li>District de Münster</li>
<li>Grand Est</li>
<li>Latium</li>
<li>Moravie</li>
<li>Rhénanie-du-Nord-Westphalie</li>
<li>Svealand</li>
<li>Vienne (Autriche)</li>
</region>
<settlement><li>Bonn</li>
<li>Brno</li>
<li>Münster</li>
<li>Rome</li>
<li>Stockholm</li>
<li>Strasbourg</li>
<li>Vienne (Autriche)</li>
</settlement>
</list>
<tree><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Banerjee, Srinita" sort="Banerjee, Srinita" uniqKey="Banerjee S" first="Srinita" last="Banerjee">Srinita Banerjee</name>
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<name sortKey="Blatt, Katharina" sort="Blatt, Katharina" uniqKey="Blatt K" first="Katharina" last="Blatt">Katharina Blatt</name>
<name sortKey="Chen, Kuan Wei" sort="Chen, Kuan Wei" uniqKey="Chen K" first="Kuan-Wei" last="Chen">Kuan-Wei Chen</name>
<name sortKey="Focke Tejkl, Margit" sort="Focke Tejkl, Margit" uniqKey="Focke Tejkl M" first="Margit" last="Focke-Tejkl">Margit Focke-Tejkl</name>
<name sortKey="Resch, Yvonne" sort="Resch, Yvonne" uniqKey="Resch Y" first="Yvonne" last="Resch">Yvonne Resch</name>
<name sortKey="Swoboda, Ines" sort="Swoboda, Ines" uniqKey="Swoboda I" first="Ines" last="Swoboda">Ines Swoboda</name>
<name sortKey="Valent, Peter" sort="Valent, Peter" uniqKey="Valent P" first="Peter" last="Valent">Peter Valent</name>
<name sortKey="Valenta, Rudolf" sort="Valenta, Rudolf" uniqKey="Valenta R" first="Rudolf" last="Valenta">Rudolf Valenta</name>
<name sortKey="Vrtala, Susanne" sort="Vrtala, Susanne" uniqKey="Vrtala S" first="Susanne" last="Vrtala">Susanne Vrtala</name>
</country>
<country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Novak, Natalija" sort="Novak, Natalija" uniqKey="Novak N" first="Natalija" last="Novak">Natalija Novak</name>
</region>
<name sortKey="Malkus, Ursula" sort="Malkus, Ursula" uniqKey="Malkus U" first="Ursula" last="Malkus">Ursula Malkus</name>
<name sortKey="Tacke, Sebastian" sort="Tacke, Sebastian" uniqKey="Tacke S" first="Sebastian" last="Tacke">Sebastian Tacke</name>
</country>
<country name="Suède"><region name="Svealand"><name sortKey="Wickman, Magnus" sort="Wickman, Magnus" uniqKey="Wickman M" first="Magnus" last="Wickman">Magnus Wickman</name>
</region>
<name sortKey="Van Hage, Marianne" sort="Van Hage, Marianne" uniqKey="Van Hage M" first="Marianne" last="Van Hage">Marianne Van Hage</name>
</country>
<country name="Italie"><region name="Latium"><name sortKey="Ferrara, Rosetta" sort="Ferrara, Rosetta" uniqKey="Ferrara R" first="Rosetta" last="Ferrara">Rosetta Ferrara</name>
</region>
<name sortKey="Mari, Adriano" sort="Mari, Adriano" uniqKey="Mari A" first="Adriano" last="Mari">Adriano Mari</name>
</country>
<country name="France"><region name="Grand Est"><name sortKey="Purohit, Ashok" sort="Purohit, Ashok" uniqKey="Purohit A" first="Ashok" last="Purohit">Ashok Purohit</name>
</region>
<name sortKey="Pauli, Gabrielle" sort="Pauli, Gabrielle" uniqKey="Pauli G" first="Gabrielle" last="Pauli">Gabrielle Pauli</name>
</country>
<country name="Zimbabwe"><noRegion><name sortKey="Sibanda, Elopy N" sort="Sibanda, Elopy N" uniqKey="Sibanda E" first="Elopy N" last="Sibanda">Elopy N. Sibanda</name>
</noRegion>
<name sortKey="Ndlovu, Portia" sort="Ndlovu, Portia" uniqKey="Ndlovu P" first="Portia" last="Ndlovu">Portia Ndlovu</name>
</country>
<country name="Australie"><noRegion><name sortKey="Thomas, Wayne R" sort="Thomas, Wayne R" uniqKey="Thomas W" first="Wayne R" last="Thomas">Wayne R. Thomas</name>
</noRegion>
</country>
<country name="République tchèque"><region name="Moravie"><name sortKey="Krzyzanek, Vladislav" sort="Krzyzanek, Vladislav" uniqKey="Krzyzanek V" first="Vladislav" last="Krzyzanek">Vladislav Krzyzanek</name>
</region>
</country>
</tree>
</affiliations>
</record>

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   |area=    AustralieFrV1
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   |texte=   Der p 11 is a major allergen for house dust mite-allergic patients suffering from atopic dermatitis.
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	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les relations entre la France et l'Australie

Der p 11 is a major allergen for house dust mite-allergic patients suffering from atopic dermatitis.

Der p 11 is a major allergen for house dust mite-allergic patients suffering from atopic dermatitis.

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