Genomic prediction of celiac disease targeting HLA-positive individuals.
Identifieur interne : 002B51 ( PubMed/Checkpoint ); précédent : 002B50; suivant : 002B52Genomic prediction of celiac disease targeting HLA-positive individuals.
Auteurs : Gad Abraham [Australie] ; Alexia Rohmer [Australie] ; Jason A. Tye-Din [Australie] ; Michael Inouye [Australie]Source :
- Genome medicine [ 1756-994X ] ; 2015.
Abstract
Genomic prediction aims to leverage genome-wide genetic data towards better disease diagnostics and risk scores. We have previously published a genomic risk score (GRS) for celiac disease (CD), a common and highly heritable autoimmune disease, which differentiates between CD cases and population-based controls at a clinically-relevant predictive level, improving upon other gene-based approaches. HLA risk haplotypes, particularly HLA-DQ2.5, are necessary but not sufficient for CD, with at least one HLA risk haplotype present in up to half of most Caucasian populations. Here, we assess a genomic prediction strategy that specifically targets this common genetic susceptibility subtype, utilizing a supervised learning procedure for CD that leverages known HLA-DQ2.5 risk.
DOI: 10.1186/s13073-015-0196-5
PubMed: 26244058
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:26244058Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genomic prediction of celiac disease targeting HLA-positive individuals.</title><author><name sortKey="Abraham, Gad" sort="Abraham, Gad" uniqKey="Abraham G" first="Gad" last="Abraham">Gad Abraham</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Systems Genomics, School of BioSciences, The University of Melbourne, Parkville, 3010 Victoria Australia ; Medical Systems Biology, Department of Pathology and Department of Microbiology & Immunology, The University of Melbourne, Parkville, 3010 Victoria Australia.</nlm:affiliation><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Rohmer, Alexia" sort="Rohmer, Alexia" uniqKey="Rohmer A" first="Alexia" last="Rohmer">Alexia Rohmer</name><affiliation wicri:level="4"><nlm:affiliation>Medical Systems Biology, Department of Pathology and Department of Microbiology & Immunology, The University of Melbourne, Parkville, 3010 Victoria Australia ; Faculty of Life Science, University of Strasbourg, Strasbourg, 67084 CEDEX France.</nlm:affiliation><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Tye Din, Jason A" sort="Tye Din, Jason A" uniqKey="Tye Din J" first="Jason A" last="Tye-Din">Jason A. Tye-Din</name><affiliation wicri:level="4"><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, 3052 Victoria Australia ; Department of Medical Biology, The University of Melbourne, Parkville, 3010 Victoria Australia ; Department of Gastroenterology, The Royal Melbourne Hospital, Grattan St., Parkville, 3050 Victoria Australia ; Murdoch Children's Research Institute, Flemington Road, Parkville, Victoria 3050 Australia.</nlm:affiliation><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Inouye, Michael" sort="Inouye, Michael" uniqKey="Inouye M" first="Michael" last="Inouye">Michael Inouye</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Systems Genomics, School of BioSciences, The University of Melbourne, Parkville, 3010 Victoria Australia ; Medical Systems Biology, Department of Pathology and Department of Microbiology & Immunology, The University of Melbourne, Parkville, 3010 Victoria Australia.</nlm:affiliation><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26244058</idno><idno type="pmid">26244058</idno><idno type="doi">10.1186/s13073-015-0196-5</idno><idno type="wicri:Area/PubMed/Corpus">002B86</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002B86</idno><idno type="wicri:Area/PubMed/Curation">002B14</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002B14</idno><idno type="wicri:Area/PubMed/Checkpoint">002B14</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002B14</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Genomic prediction of celiac disease targeting HLA-positive individuals.</title><author><name sortKey="Abraham, Gad" sort="Abraham, Gad" uniqKey="Abraham G" first="Gad" last="Abraham">Gad Abraham</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Systems Genomics, School of BioSciences, The University of Melbourne, Parkville, 3010 Victoria Australia ; Medical Systems Biology, Department of Pathology and Department of Microbiology & Immunology, The University of Melbourne, Parkville, 3010 Victoria Australia.</nlm:affiliation><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Rohmer, Alexia" sort="Rohmer, Alexia" uniqKey="Rohmer A" first="Alexia" last="Rohmer">Alexia Rohmer</name><affiliation wicri:level="4"><nlm:affiliation>Medical Systems Biology, Department of Pathology and Department of Microbiology & Immunology, The University of Melbourne, Parkville, 3010 Victoria Australia ; Faculty of Life Science, University of Strasbourg, Strasbourg, 67084 CEDEX France.</nlm:affiliation><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Tye Din, Jason A" sort="Tye Din, Jason A" uniqKey="Tye Din J" first="Jason A" last="Tye-Din">Jason A. Tye-Din</name><affiliation wicri:level="4"><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, 3052 Victoria Australia ; Department of Medical Biology, The University of Melbourne, Parkville, 3010 Victoria Australia ; Department of Gastroenterology, The Royal Melbourne Hospital, Grattan St., Parkville, 3050 Victoria Australia ; Murdoch Children's Research Institute, Flemington Road, Parkville, Victoria 3050 Australia.</nlm:affiliation><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Inouye, Michael" sort="Inouye, Michael" uniqKey="Inouye M" first="Michael" last="Inouye">Michael Inouye</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Systems Genomics, School of BioSciences, The University of Melbourne, Parkville, 3010 Victoria Australia ; Medical Systems Biology, Department of Pathology and Department of Microbiology & Immunology, The University of Melbourne, Parkville, 3010 Victoria Australia.</nlm:affiliation><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author></analytic><series><title level="j">Genome medicine</title><idno type="ISSN">1756-994X</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Genomic prediction aims to leverage genome-wide genetic data towards better disease diagnostics and risk scores. We have previously published a genomic risk score (GRS) for celiac disease (CD), a common and highly heritable autoimmune disease, which differentiates between CD cases and population-based controls at a clinically-relevant predictive level, improving upon other gene-based approaches. HLA risk haplotypes, particularly HLA-DQ2.5, are necessary but not sufficient for CD, with at least one HLA risk haplotype present in up to half of most Caucasian populations. Here, we assess a genomic prediction strategy that specifically targets this common genetic susceptibility subtype, utilizing a supervised learning procedure for CD that leverages known HLA-DQ2.5 risk.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">26244058</PMID><DateCreated><Year>2015</Year><Month>08</Month><Day>05</Day></DateCreated><DateCompleted><Year>2015</Year><Month>08</Month><Day>05</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">1756-994X</ISSN><JournalIssue CitedMedium="Print"><Volume>7</Volume><Issue>1</Issue><PubDate><Year>2015</Year></PubDate></JournalIssue><Title>Genome medicine</Title><ISOAbbreviation>Genome Med</ISOAbbreviation></Journal><ArticleTitle>Genomic prediction of celiac disease targeting HLA-positive individuals.</ArticleTitle><Pagination><MedlinePgn>72</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s13073-015-0196-5</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Genomic prediction aims to leverage genome-wide genetic data towards better disease diagnostics and risk scores. We have previously published a genomic risk score (GRS) for celiac disease (CD), a common and highly heritable autoimmune disease, which differentiates between CD cases and population-based controls at a clinically-relevant predictive level, improving upon other gene-based approaches. HLA risk haplotypes, particularly HLA-DQ2.5, are necessary but not sufficient for CD, with at least one HLA risk haplotype present in up to half of most Caucasian populations. Here, we assess a genomic prediction strategy that specifically targets this common genetic susceptibility subtype, utilizing a supervised learning procedure for CD that leverages known HLA-DQ2.5 risk.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Using L1/L2-regularized support-vector machines trained on large European case-control datasets, we constructed novel CD GRSs specific to individuals with HLA-DQ2.5 risk haplotypes (GRS-DQ2.5) and compared them with the predictive power of the existing CD GRS (GRS14) as well as two haplotype-based approaches, externally validating the results in a North American case-control study.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Consistent with previous observations, both the existing GRS14 and the GRS-DQ2.5 had better predictive performance than the HLA haplotype approaches. GRS-DQ2.5 models, based on directly genotyped or imputed markers, achieved similar levels of predictive performance (AUC = 0.718-0.73), which were substantially higher than those obtained from the DQ2.5 zygosity alone (AUC = 0.558), the HLA risk haplotype method (AUC = 0.634), or the generic GRS14 (AUC = 0.679). In a screening model of at-risk individuals, the GRS-DQ2.5 lowered the number of unnecessary follow-up tests for CD across most sensitivity levels. Relative to a baseline implicating all DQ2.5-positive individuals for follow-up, the GRS-DQ2.5 resulted in a net saving of 2.2 unnecessary follow-up tests for each justified test while still capturing 90 % of DQ2.5-positive CD cases.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Genomic risk scores for CD that target genetically at-risk sub-groups improve predictive performance beyond traditional approaches and may represent a useful strategy for prioritizing individuals at increased risk of disease, thus potentially reducing unnecessary follow-up diagnostic tests.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Abraham</LastName><ForeName>Gad</ForeName><Initials>G</Initials><Identifier Source="ORCID">0000-0003-4853-0118</Identifier><AffiliationInfo><Affiliation>Centre for Systems Genomics, School of BioSciences, The University of Melbourne, Parkville, 3010 Victoria Australia ; Medical Systems Biology, Department of Pathology and Department of Microbiology & Immunology, The University of Melbourne, Parkville, 3010 Victoria Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rohmer</LastName><ForeName>Alexia</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Medical Systems Biology, Department of Pathology and Department of Microbiology & Immunology, The University of Melbourne, Parkville, 3010 Victoria Australia ; Faculty of Life Science, University of Strasbourg, Strasbourg, 67084 CEDEX France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tye-Din</LastName><ForeName>Jason A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, 3052 Victoria Australia ; Department of Medical Biology, The University of Melbourne, Parkville, 3010 Victoria Australia ; Department of Gastroenterology, The Royal Melbourne Hospital, Grattan St., Parkville, 3050 Victoria Australia ; Murdoch Children's Research Institute, Flemington Road, Parkville, Victoria 3050 Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Inouye</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Centre for Systems Genomics, School of BioSciences, The University of Melbourne, Parkville, 3010 Victoria Australia ; Medical Systems Biology, Department of Pathology and Department of Microbiology & Immunology, The University of Melbourne, Parkville, 3010 Victoria Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>07</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Genome Med</MedlineTA><NlmUniqueID>101475844</NlmUniqueID><ISSNLinking>1756-994X</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>PLoS Genet. 2009 Oct;5(10):e1000678</RefSource><PMID Version="1">19816555</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2012;7(5):e36926</RefSource><PMID Version="1">22615847</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2014 Oct 2;371(14):1304-15</RefSource><PMID Version="1">25271603</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hum Immunol. 2009 Jan;70(1):55-9</RefSource><PMID Version="1">19027045</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Genet. 2011 Feb;7(2):e1002004</RefSource><PMID Version="1">21383967</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2014 Jul 07;9(7):e101428</RefSource><PMID Version="1">24999842</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2013 Jun 06;8(6):e64683</RefSource><PMID Version="1">23762245</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Gastroenterol Hepatol. 2006 Mar;4(3):315-9</RefSource><PMID Version="1">16527694</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hum Immunol. 2003 Apr;64(4):469-77</RefSource><PMID Version="1">12651074</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Sci Transl Med. 2010 Jul 21;2(41):41ra51</RefSource><PMID Version="1">20650871</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2010 Apr;42(4):295-302</RefSource><PMID Version="1">20190752</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Gut. 2006 Jul;55(7):1037-46</RefSource><PMID Version="1">16766754</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Hum Genet. 2013 Jun 6;92(6):1008-12</RefSource><PMID Version="1">23731541</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>BMC Bioinformatics. 2012 May 10;13:88</RefSource><PMID Version="1">22574887</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2008 Apr;40(4):395-402</RefSource><PMID Version="1">18311140</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Gut. 2006 Jun;55(6):803-8</RefSource><PMID Version="1">16354797</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2014 Jul 3;371(1):42-9</RefSource><PMID Version="1">24988556</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Genet. 2011 Jan 27;7(1):e1001283</RefSource><PMID Version="1">21298027</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Gigascience. 2015 Feb 25;4:7</RefSource><PMID Version="1">25722852</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Genet. 2011 Dec;7(12):e1002406</RefSource><PMID Version="1">22174698</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Genet. 2014 Feb 13;10(2):e1004137</RefSource><PMID Version="1">24550740</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genet Epidemiol. 2013 Feb;37(2):184-95</RefSource><PMID Version="1">23203348</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Gut. 2014 Mar;63(3):415-22</RefSource><PMID Version="1">23704318</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Genet. 2013 Jul;14 (7):507-15</RefSource><PMID Version="1">23774735</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Genet. 2008 Jul 25;4(7):e1000130</RefSource><PMID Version="1">18654633</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2014 Jan 02;9(1):e84163</RefSource><PMID Version="1">24392112</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2009 Jun;41(6):703-7</RefSource><PMID Version="1">19430480</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>BMC Med. 2013 Aug 28;11:188</RefSource><PMID Version="1">23981538</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Gastroenterol Hepatol. 2014 Nov;11(11):655-63</RefSource><PMID Version="1">25266110</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Annu Rev Immunol. 2011;29:493-525</RefSource><PMID Version="1">21219178</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>BMC Bioinformatics. 2011 Mar 17;12:77</RefSource><PMID Version="1">21414208</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hum Mol Genet. 2009 Nov 1;18(21):4219-25</RefSource><PMID Version="1">19648293</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2008 Sep;40(9):1059-61</RefSource><PMID Version="1">19165918</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Intern Med J. 2015 Apr;45(4):441-50</RefSource><PMID Version="1">25827511</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Scand J Gastroenterol. 2006 Feb;41(2):191-9</RefSource><PMID Version="1">16484124</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Genet. 2014 Nov 13;10(11):e1004754</RefSource><PMID Version="1">25393026</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Hum Genet. 2007 Sep;81(3):559-75</RefSource><PMID Version="1">17701901</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2011 Nov 06;43(12):1193-201</RefSource><PMID Version="1">22057235</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Pharmacogenomics J. 2014 Apr;14(2):192-200</RefSource><PMID Version="1">23712092</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Intern Med. 2003 Feb 10;163(3):286-92</RefSource><PMID Version="1">12578508</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Gastroenterol Hepatol. 2005 Sep;3(9):843-51</RefSource><PMID Version="1">16234020</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Pediatr Gastroenterol Nutr. 2012 Jan;54(1):136-60</RefSource><PMID Version="1">22197856</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2015 Jun;47(6):577-8</RefSource><PMID Version="1">25894500</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genome Res. 2014 Sep;24(9):1550-7</RefSource><PMID Version="1">24963154</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2014 Apr 09;9(4):e93766</RefSource><PMID Version="1">24718290</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2014 Oct 2;371(14):1295-303</RefSource><PMID Version="1">25271602</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2007 Jul;39(7):827-9</RefSource><PMID Version="1">17558408</PMID></CommentsCorrections></CommentsCorrectionsList><OtherID Source="NLM">PMC4523954</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>04</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>07</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>8</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>8</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>8</Month><Day>6</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26244058</ArticleId><ArticleId IdType="doi">10.1186/s13073-015-0196-5</ArticleId><ArticleId IdType="pii">196</ArticleId><ArticleId IdType="pmc">PMC4523954</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li></country><region><li>Victoria (État)</li></region><settlement><li>Melbourne</li></settlement><orgName><li>Université de Melbourne</li></orgName></list><tree><country name="Australie"><region name="Victoria (État)"><name sortKey="Abraham, Gad" sort="Abraham, Gad" uniqKey="Abraham G" first="Gad" last="Abraham">Gad Abraham</name></region><name sortKey="Inouye, Michael" sort="Inouye, Michael" uniqKey="Inouye M" first="Michael" last="Inouye">Michael Inouye</name><name sortKey="Rohmer, Alexia" sort="Rohmer, Alexia" uniqKey="Rohmer A" first="Alexia" last="Rohmer">Alexia Rohmer</name><name sortKey="Tye Din, Jason A" sort="Tye Din, Jason A" uniqKey="Tye Din J" first="Jason A" last="Tye-Din">Jason A. Tye-Din</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002B51 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 002B51 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= PubMed
|étape= Checkpoint
|type= RBID
|clé= pubmed:26244058
|texte= Genomic prediction of celiac disease targeting HLA-positive individuals.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:26244058" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |