AustralieFrV1, PubMed, Checkpoint, bibRecord, 002A29

Intrinsic factors and the embryonic environment influence the formation of extragonadal teratomas during gestation.

Identifieur interne : 002A29 ( PubMed/Checkpoint ); précédent : 002A28; suivant : 002A30

Intrinsic factors and the embryonic environment influence the formation of extragonadal teratomas during gestation.

Auteurs : Constantinos Economou [Royaume-Uni] ; Anestis Tsakiridis [Royaume-Uni] ; Filip J. Wymeersch [Royaume-Uni] ; Sabrina Gordon-Keylock [Royaume-Uni] ; Robert E. Dewhurst [Australie] ; Dawn Fisher [Royaume-Uni] ; Alexander Medvinsky [Royaume-Uni] ; Andrew J H. Smith [Royaume-Uni] ; Valerie Wilson [Royaume-Uni]

Source :

BMC developmental biology [ 1471-213X ] ; 2015.

RBID : pubmed:26453549

Descripteurs français

KwdFr :
- Animaux, Cellules souches embryonnaires (métabolisme), Cellules souches pluripotentes (métabolisme), Embryon de mammifère (anatomopathologie), Embryon de mammifère (métabolisme), Facteur de transcription Oct-3 (génétique), Facteur de transcription Oct-3 (métabolisme), Humains, Protéine homéotique Nanog, Protéines foetales (métabolisme), Protéines à domaine boîte-T (métabolisme), Protéines à homéodomaine (génétique), Queue (embryologie), Souris, Tératome (anatomopathologie), Tératome (métabolisme).
MESH :
- anatomopathologie : Embryon de mammifère, Tératome.
- embryologie : Queue.
- génétique : Facteur de transcription Oct-3, Protéines à homéodomaine.
- métabolisme : Cellules souches embryonnaires, Cellules souches pluripotentes, Embryon de mammifère, Facteur de transcription Oct-3, Protéines foetales, Protéines à domaine boîte-T, Tératome.
- Animaux, Humains, Protéine homéotique Nanog, Souris.

English descriptors

KwdEn :
- Animals, Embryo, Mammalian (metabolism), Embryo, Mammalian (pathology), Embryonic Stem Cells (metabolism), Fetal Proteins (metabolism), Homeodomain Proteins (genetics), Humans, Mice, Nanog Homeobox Protein, Octamer Transcription Factor-3 (genetics), Octamer Transcription Factor-3 (metabolism), Pluripotent Stem Cells (metabolism), T-Box Domain Proteins (metabolism), Tail (embryology), Teratoma (metabolism), Teratoma (pathology).
MESH :
- chemical , genetics : Homeodomain Proteins, Octamer Transcription Factor-3.
- chemical , metabolism : Fetal Proteins, Octamer Transcription Factor-3, T-Box Domain Proteins.
- embryology : Tail.
- metabolism : Embryo, Mammalian, Embryonic Stem Cells, Pluripotent Stem Cells, Teratoma.
- pathology : Embryo, Mammalian, Teratoma.
- Animals, Humans, Mice, Nanog Homeobox Protein.

Abstract

Pluripotent cells are present in early embryos until the levels of the pluripotency regulator Oct4 drop at the beginning of somitogenesis. Elevating Oct4 levels in explanted post-pluripotent cells in vitro restores their pluripotency. Cultured pluripotent cells can participate in normal development when introduced into host embryos up to the end of gastrulation. In contrast, pluripotent cells efficiently seed malignant teratocarcinomas in adult animals. In humans, extragonadal teratomas and teratocarcinomas are most frequently found in the sacrococcygeal region of neonates, suggesting that these tumours originate from cells in the posterior of the embryo that either reactivate or fail to switch off their pluripotent status. However, experimental models for the persistence or reactivation of pluripotency during embryonic development are lacking.

DOI: 10.1186/s12861-015-0084-7
PubMed: 26453549

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 002824
to stream PubMed, to step Curation: 002755

Links to Exploration step

pubmed:26453549

Le document en format XML

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<term>Humans</term>
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<term>Octamer Transcription Factor-3 (metabolism)</term>
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<term>Embryon de mammifère (anatomopathologie)</term>
<term>Embryon de mammifère (métabolisme)</term>
<term>Facteur de transcription Oct-3 (génétique)</term>
<term>Facteur de transcription Oct-3 (métabolisme)</term>
<term>Humains</term>
<term>Protéine homéotique Nanog</term>
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<term>Protéines à domaine boîte-T (métabolisme)</term>
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<term>Tératome (métabolisme)</term>
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<term>Octamer Transcription Factor-3</term>
<term>T-Box Domain Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Embryon de mammifère</term>
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<term>Pluripotent Stem Cells</term>
<term>Teratoma</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cellules souches embryonnaires</term>
<term>Cellules souches pluripotentes</term>
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<front><div type="abstract" xml:lang="en">Pluripotent cells are present in early embryos until the levels of the pluripotency regulator Oct4 drop at the beginning of somitogenesis. Elevating Oct4 levels in explanted post-pluripotent cells in vitro restores their pluripotency. Cultured pluripotent cells can participate in normal development when introduced into host embryos up to the end of gastrulation. In contrast, pluripotent cells efficiently seed malignant teratocarcinomas in adult animals. In humans, extragonadal teratomas and teratocarcinomas are most frequently found in the sacrococcygeal region of neonates, suggesting that these tumours originate from cells in the posterior of the embryo that either reactivate or fail to switch off their pluripotent status. However, experimental models for the persistence or reactivation of pluripotency during embryonic development are lacking.</div>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Pluripotent cells are present in early embryos until the levels of the pluripotency regulator Oct4 drop at the beginning of somitogenesis. Elevating Oct4 levels in explanted post-pluripotent cells in vitro restores their pluripotency. Cultured pluripotent cells can participate in normal development when introduced into host embryos up to the end of gastrulation. In contrast, pluripotent cells efficiently seed malignant teratocarcinomas in adult animals. In humans, extragonadal teratomas and teratocarcinomas are most frequently found in the sacrococcygeal region of neonates, suggesting that these tumours originate from cells in the posterior of the embryo that either reactivate or fail to switch off their pluripotent status. However, experimental models for the persistence or reactivation of pluripotency during embryonic development are lacking.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We manually injected embryonic stem cells into conceptuses at E9.5 to test whether the presence of pluripotent cells at this stage correlates with teratocarcinoma formation. We then examined the effects of reactivating embryonic Oct4 expression ubiquitously or in combination with Nanog within the primitive streak (PS)/tail bud (TB) using a transgenic mouse line and embryo chimeras carrying a PS/TB-specific heterologous gene expression cassette respectively.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Here, we show that pluripotent cells seed teratomas in post-gastrulation embryos. However, at these stages, induced ubiquitous expression of Oct4 does not lead to restoration of pluripotency (indicated by Nanog expression) and tumour formation in utero, but instead causes a severe phenotype in the extending anteroposterior axis. Use of a more restricted T(Bra) promoter transgenic system enabling inducible ectopic expression of Oct4 and Nanog specifically in the posteriorly-located primitive streak (PS) and tail bud (TB) led to similar axial malformations to those induced by Oct4 alone. These cells underwent induction of pluripotency marker expression in Epiblast Stem Cell (EpiSC) explants derived from somitogenesis-stage embryos, but no teratocarcinoma formation was observed in vivo.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our findings show that although pluripotent cells with teratocarcinogenic potential can be produced in vitro by the overexpression of pluripotency regulators in explanted somitogenesis-stage somatic cells, the in vivo induction of these genes does not yield tumours. This suggests a restrictive regulatory role of the embryonic microenvironment in the induction of pluripotency.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Economou</LastName>
<ForeName>Constantinos</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>MRC Centre for Regenerative Medicine, School of Biological Sciences, SCRM Building, The University of Edinburgh, Edinburgh bioQuarter, 5 Little France Drive, Edinburgh, EH16 4UU, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tsakiridis</LastName>
<ForeName>Anestis</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>MRC Centre for Regenerative Medicine, School of Biological Sciences, SCRM Building, The University of Edinburgh, Edinburgh bioQuarter, 5 Little France Drive, Edinburgh, EH16 4UU, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wymeersch</LastName>
<ForeName>Filip J</ForeName>
<Initials>FJ</Initials>
<AffiliationInfo><Affiliation>MRC Centre for Regenerative Medicine, School of Biological Sciences, SCRM Building, The University of Edinburgh, Edinburgh bioQuarter, 5 Little France Drive, Edinburgh, EH16 4UU, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gordon-Keylock</LastName>
<ForeName>Sabrina</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>MRC Centre for Regenerative Medicine, School of Biological Sciences, SCRM Building, The University of Edinburgh, Edinburgh bioQuarter, 5 Little France Drive, Edinburgh, EH16 4UU, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dewhurst</LastName>
<ForeName>Robert E</ForeName>
<Initials>RE</Initials>
<AffiliationInfo><Affiliation>Drug Discovery Unit, Telethon Kids Institute, PO Box 855, West Perth, WA, 6872, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fisher</LastName>
<ForeName>Dawn</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>MRC Centre for Regenerative Medicine, School of Biological Sciences, SCRM Building, The University of Edinburgh, Edinburgh bioQuarter, 5 Little France Drive, Edinburgh, EH16 4UU, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Medvinsky</LastName>
<ForeName>Alexander</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>MRC Centre for Regenerative Medicine, School of Biological Sciences, SCRM Building, The University of Edinburgh, Edinburgh bioQuarter, 5 Little France Drive, Edinburgh, EH16 4UU, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Smith</LastName>
<ForeName>Andrew J H</ForeName>
<Initials>AJ</Initials>
<AffiliationInfo><Affiliation>MRC Centre for Regenerative Medicine, School of Biological Sciences, SCRM Building, The University of Edinburgh, Edinburgh bioQuarter, 5 Little France Drive, Edinburgh, EH16 4UU, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wilson</LastName>
<ForeName>Valerie</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>MRC Centre for Regenerative Medicine, School of Biological Sciences, SCRM Building, The University of Edinburgh, Edinburgh bioQuarter, 5 Little France Drive, Edinburgh, EH16 4UU, UK. v.wilson@ed.ac.uk.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>G0802097</GrantID>
<Agency>Medical Research Council</Agency>
<Country>United Kingdom</Country>
</Grant>
<Grant><GrantID>MR/K011200/1</GrantID>
<Agency>Medical Research Council</Agency>
<Country>United Kingdom</Country>
</Grant>
<Grant><GrantID>MR/L012766/1</GrantID>
<Agency>Medical Research Council</Agency>
<Country>United Kingdom</Country>
</Grant>
<Grant><GrantID>G080297</GrantID>
<Agency>Medical Research Council</Agency>
<Country>United Kingdom</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2015</Year>
<Month>10</Month>
<Day>09</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>BMC Dev Biol</MedlineTA>
<NlmUniqueID>100966973</NlmUniqueID>
<ISSNLinking>1471-213X</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C075937">Brachyury protein</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D005326">Fetal Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D018398">Homeodomain Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000071317">Nanog Homeobox Protein</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C475540">Nanog protein, mouse</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D050814">Octamer Transcription Factor-3</NameOfSubstance>
</Chemical>
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<NameOfSubstance UI="C494174">Pou5f1 protein, mouse</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
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</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Genes Dev. 1999 Dec 15;13(24):3185-90</RefSource>
<PMID Version="1">10617567</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nature. 2013 Oct 17;502(7471):340-5</RefSource>
<PMID Version="1">24025773</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):7963-8</RefSource>
<PMID Version="1">10859354</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Biotechnol. 2002 Jan;20(1):83-7</RefSource>
<PMID Version="1">11753367</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Development. 2002 Oct;129(20):4855-66</RefSource>
<PMID Version="1">12361976</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Genes Dev. 2003 Jan 1;17(1):126-40</RefSource>
<PMID Version="1">12514105</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Development. 2003 Sep;130(17):4217-27</RefSource>
<PMID Version="1">12874139</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Radiographics. 2004 Mar-Apr;24(2):387-404</RefSource>
<PMID Version="1">15026588</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Pediatr Surg. 2004 Jul;39(7):1003-13</RefSource>
<PMID Version="1">15213888</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 1978 Jun;75(6):2834-8</RefSource>
<PMID Version="1">275854</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Comp Pathol. 1982 Apr;92(2):273-84</RefSource>
<PMID Version="1">7085943</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS Genet. 2013 Nov;9(11):e1003957</RefSource>
<PMID Version="1">24244203</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Curr Biol. 2013 Nov 18;23(22):2233-44</RefSource>
<PMID Version="1">24210613</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mol Cell. 2000 Jan;5(1):35-47</RefSource>
<PMID Version="1">10678167</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nature. 1984 May 17-23;309(5965):255-6</RefSource>
<PMID Version="1">6717601</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Curr Probl Cancer. 1985 Sep;9(9):1-53</RefSource>
<PMID Version="1">2415302</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nature. 1990 Feb 15;343(6259):657-9</RefSource>
<PMID Version="1">1689462</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>EMBO J. 1990 Jul;9(7):2185-95</RefSource>
<PMID Version="1">2357966</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Genes Dev. 1990 Dec;4(12B):2308-18</RefSource>
<PMID Version="1">1703981</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Development. 1991 Nov;113(3):891-911</RefSource>
<PMID Version="1">1821858</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Development. 1994 Dec;120(12):3621-37</RefSource>
<PMID Version="1">7821227</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Development. 1994 Apr;120(4):803-13</RefSource>
<PMID Version="1">7600958</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Development. 1996 Mar;122(3):881-94</RefSource>
<PMID Version="1">8631266</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mech Dev. 1996 May;56(1-2):139-49</RefSource>
<PMID Version="1">8798154</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):9067-72</RefSource>
<PMID Version="1">8799155</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Dev Biol. 1997 Sep 15;189(2):161-73</RefSource>
<PMID Version="1">9299111</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Dev Biol. 1997 Dec 1;192(1):45-58</RefSource>
<PMID Version="1">9405096</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Biosci Biotechnol Biochem. 1999 Mar;63(3):608-9</RefSource>
<PMID Version="1">10227154</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Dev Growth Differ. 1999 Jun;41(3):253-64</RefSource>
<PMID Version="1">10400387</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cancer Res. 1964 Oct;24:1544-51</RefSource>
<PMID Version="1">14234000</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Dev Dyn. 2005 Jan;232(1):180-90</RefSource>
<PMID Version="1">15580630</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Rev Cancer. 2005 Mar;5(3):210-22</RefSource>
<PMID Version="1">15738984</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cell. 2005 May 6;121(3):465-77</RefSource>
<PMID Version="1">15882627</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Gene Expr Patterns. 2005 Jun;5(5):639-46</RefSource>
<PMID Version="1">15939376</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Clin Pract Cardiovasc Med. 2006 Mar;3 Suppl 1:S114-22</RefSource>
<PMID Version="1">16501617</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cell. 2006 Aug 25;126(4):663-76</RefSource>
<PMID Version="1">16904174</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Science. 2006 Dec 8;314(5805):1595-8</RefSource>
<PMID Version="1">17095659</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nature. 2007 Jul 12;448(7150):196-9</RefSource>
<PMID Version="1">17597760</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nature. 2007 Jul 12;448(7150):191-5</RefSource>
<PMID Version="1">17597762</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nature. 2007 Jul 19;448(7151):313-7</RefSource>
<PMID Version="1">17554338</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Int J Androl. 2007 Aug;30(4):256-63; discussion 263-4</RefSource>
<PMID Version="1">17705807</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nature. 2007 Dec 20;450(7173):1230-4</RefSource>
<PMID Version="1">18097409</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Int J Dev Biol. 2008;52(4):333-44</RefSource>
<PMID Version="1">18415933</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Prenat Diagn. 2008 Nov;28(11):1048-51</RefSource>
<PMID Version="1">18973151</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Development. 2009 Jul;136(14):2311-22</RefSource>
<PMID Version="1">19542351</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Methods. 2010 Jan;7(1):53-5</RefSource>
<PMID Version="1">20010832</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Int J Androl. 2011 Aug;34(4 Pt 2):e218-33</RefSource>
<PMID Version="1">21696393</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Development. 2012 Jul;139(13):2288-98</RefSource>
<PMID Version="1">22669820</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Development. 2012 Nov;139(22):4123-32</RefSource>
<PMID Version="1">23034635</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nucleic Acids Res. 2012 Oct;40(19):e153</RefSource>
<PMID Version="1">22798478</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>EMBO J. 2012 Dec 12;31(24):4547-62</RefSource>
<PMID Version="1">23178592</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cell Rep. 2012 Dec 27;2(6):1571-8</RefSource>
<PMID Version="1">23200857</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Dev Biol. 2013 May 1;377(1):67-78</RefSource>
<PMID Version="1">23473982</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Int J Dev Biol. 2013;57(2-4):211-9</RefSource>
<PMID Version="1">23784832</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Development. 2014 Mar;141(6):1209-21</RefSource>
<PMID Version="1">24595287</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004622" MajorTopicYN="N">Embryo, Mammalian</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053595" MajorTopicYN="N">Embryonic Stem Cells</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005326" MajorTopicYN="N">Fetal Proteins</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018398" MajorTopicYN="N">Homeodomain Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000071317" MajorTopicYN="N">Nanog Homeobox Protein</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D050814" MajorTopicYN="N">Octamer Transcription Factor-3</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D039904" MajorTopicYN="N">Pluripotent Stem Cells</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020825" MajorTopicYN="N">T-Box Domain Proteins</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013623" MajorTopicYN="N">Tail</DescriptorName>
<QualifierName UI="Q000196" MajorTopicYN="N">embryology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013724" MajorTopicYN="N">Teratoma</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
</MeshHeading>
</MeshHeadingList>
<OtherID Source="NLM">PMC4599726</OtherID>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year>
<Month>03</Month>
<Day>20</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2015</Year>
<Month>09</Month>
<Day>18</Day>
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<ArticleIdList><ArticleId IdType="pubmed">26453549</ArticleId>
<ArticleId IdType="doi">10.1186/s12861-015-0084-7</ArticleId>
<ArticleId IdType="pii">10.1186/s12861-015-0084-7</ArticleId>
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<affiliations><list><country><li>Australie</li>
<li>Royaume-Uni</li>
</country>
<region><li>Écosse</li>
</region>
<settlement><li>Édimbourg</li>
</settlement>
<orgName><li>Université d'Édimbourg</li>
</orgName>
</list>
<tree><country name="Royaume-Uni"><region name="Écosse"><name sortKey="Economou, Constantinos" sort="Economou, Constantinos" uniqKey="Economou C" first="Constantinos" last="Economou">Constantinos Economou</name>
</region>
<name sortKey="Fisher, Dawn" sort="Fisher, Dawn" uniqKey="Fisher D" first="Dawn" last="Fisher">Dawn Fisher</name>
<name sortKey="Gordon Keylock, Sabrina" sort="Gordon Keylock, Sabrina" uniqKey="Gordon Keylock S" first="Sabrina" last="Gordon-Keylock">Sabrina Gordon-Keylock</name>
<name sortKey="Medvinsky, Alexander" sort="Medvinsky, Alexander" uniqKey="Medvinsky A" first="Alexander" last="Medvinsky">Alexander Medvinsky</name>
<name sortKey="Smith, Andrew J H" sort="Smith, Andrew J H" uniqKey="Smith A" first="Andrew J H" last="Smith">Andrew J H. Smith</name>
<name sortKey="Tsakiridis, Anestis" sort="Tsakiridis, Anestis" uniqKey="Tsakiridis A" first="Anestis" last="Tsakiridis">Anestis Tsakiridis</name>
<name sortKey="Wilson, Valerie" sort="Wilson, Valerie" uniqKey="Wilson V" first="Valerie" last="Wilson">Valerie Wilson</name>
<name sortKey="Wymeersch, Filip J" sort="Wymeersch, Filip J" uniqKey="Wymeersch F" first="Filip J" last="Wymeersch">Filip J. Wymeersch</name>
</country>
<country name="Australie"><noRegion><name sortKey="Dewhurst, Robert E" sort="Dewhurst, Robert E" uniqKey="Dewhurst R" first="Robert E" last="Dewhurst">Robert E. Dewhurst</name>
</noRegion>
</country>
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	Serveur d'exploration sur les relations entre la France et l'Australie
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Intrinsic factors and the embryonic environment influence the formation of extragonadal teratomas during gestation.

Intrinsic factors and the embryonic environment influence the formation of extragonadal teratomas during gestation.

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