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Medical physics aspects of the synchrotron radiation therapies: Microbeam radiation therapy (MRT) and synchrotron stereotactic radiotherapy (SSRT).

Identifieur interne : 002969 ( PubMed/Checkpoint ); précédent : 002968; suivant : 002970

Medical physics aspects of the synchrotron radiation therapies: Microbeam radiation therapy (MRT) and synchrotron stereotactic radiotherapy (SSRT).

Auteurs : Elke Br Uer-Krisch [France] ; Jean-Francois Adam [France] ; Enver Alagoz [Norvège] ; Stefan Bartzsch [Royaume-Uni] ; Jeff Crosbie [Australie] ; Carlos Dewagter [Belgique] ; Andrew Dipuglia [Australie] ; Mattia Donzelli [France] ; Simon Doran [Royaume-Uni] ; Pauline Fournier [Australie] ; John Kalef-Ezra [Grèce] ; Angela Kock [Norvège] ; Michael Lerch [Australie] ; Ciara Mcerlean [Royaume-Uni] ; Uwe Oelfke [Royaume-Uni] ; Pawel Olko [Pologne] ; Marco Petasecca [Australie] ; Marco Povoli [Norvège] ; Anatoly Rosenfeld [Australie] ; Erik A. Siegbahn [Suède] ; Dan Sporea [Roumanie] ; Bjarne Stugu [Norvège]

Source :

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) [ 1724-191X ] ; 2015.

RBID : pubmed:26043881

Descripteurs français

English descriptors

KwdEn :
- Animals, Brain Neoplasms (radiotherapy), Dose Fractionation, Equipment Design, Evidence-Based Medicine, Humans, Neoplasms (surgery), Radiometry (instrumentation), Radiometry (methods), Radiosurgery (instrumentation), Radiosurgery (methods), Radiotherapy Planning, Computer-Assisted (instrumentation), Radiotherapy Planning, Computer-Assisted (methods), Radiotherapy, High-Energy (instrumentation), Radiotherapy, High-Energy (methods), Swine, Synchrotrons (instrumentation), Technology Assessment, Biomedical, Treatment Outcome.
MESH :
- instrumentation : Radiometry, Radiosurgery, Radiotherapy Planning, Computer-Assisted, Radiotherapy, High-Energy, Synchrotrons.
- methods : Radiometry, Radiosurgery, Radiotherapy Planning, Computer-Assisted, Radiotherapy, High-Energy.
- radiotherapy : Brain Neoplasms.
- surgery : Neoplasms.
- Animals, Dose Fractionation, Equipment Design, Evidence-Based Medicine, Humans, Swine, Technology Assessment, Biomedical, Treatment Outcome.

Abstract

Stereotactic Synchrotron Radiotherapy (SSRT) and Microbeam Radiation Therapy (MRT) are both novel approaches to treat brain tumor and potentially other tumors using synchrotron radiation. Although the techniques differ by their principles, SSRT and MRT share certain common aspects with the possibility of combining their advantages in the future. For MRT, the technique uses highly collimated, quasi-parallel arrays of X-ray microbeams between 50 and 600 keV. Important features of highly brilliant Synchrotron sources are a very small beam divergence and an extremely high dose rate. The minimal beam divergence allows the insertion of so called Multi Slit Collimators (MSC) to produce spatially fractionated beams of typically ∼25-75 micron-wide microplanar beams separated by wider (100-400 microns center-to-center(ctc)) spaces with a very sharp penumbra. Peak entrance doses of several hundreds of Gy are extremely well tolerated by normal tissues and at the same time provide a higher therapeutic index for various tumor models in rodents. The hypothesis of a selective radio-vulnerability of the tumor vasculature versus normal blood vessels by MRT was recently more solidified. SSRT (Synchrotron Stereotactic Radiotherapy) is based on a local drug uptake of high-Z elements in tumors followed by stereotactic irradiation with 80 keV photons to enhance the dose deposition only within the tumor. With SSRT already in its clinical trial stage at the ESRF, most medical physics problems are already solved and the implemented solutions are briefly described, while the medical physics aspects in MRT will be discussed in more detail in this paper.

DOI: 10.1016/j.ejmp.2015.04.016
PubMed: 26043881

Affiliations:

Australie, Belgique, France, Grèce, Norvège, Pologne, Roumanie, Royaume-Uni, Suède
Auvergne-Rhône-Alpes, Province de Flandre-Orientale, Rhône-Alpes, Svealand, Østlandet
Gand, Grenoble, Oslo, Stockholm

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<author><name sortKey="Oelfke, Uwe" sort="Oelfke, Uwe" uniqKey="Oelfke U" first="Uwe" last="Oelfke">Uwe Oelfke</name>
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<author><name sortKey="Olko, Pawel" sort="Olko, Pawel" uniqKey="Olko P" first="Pawel" last="Olko">Pawel Olko</name>
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<author><name sortKey="Petasecca, Marco" sort="Petasecca, Marco" uniqKey="Petasecca M" first="Marco" last="Petasecca">Marco Petasecca</name>
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<author><name sortKey="Povoli, Marco" sort="Povoli, Marco" uniqKey="Povoli M" first="Marco" last="Povoli">Marco Povoli</name>
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<author><name sortKey="Siegbahn, Erik A" sort="Siegbahn, Erik A" uniqKey="Siegbahn E" first="Erik A" last="Siegbahn">Erik A. Siegbahn</name>
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<author><name sortKey="Sporea, Dan" sort="Sporea, Dan" uniqKey="Sporea D" first="Dan" last="Sporea">Dan Sporea</name>
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<author><name sortKey="Stugu, Bjarne" sort="Stugu, Bjarne" uniqKey="Stugu B" first="Bjarne" last="Stugu">Bjarne Stugu</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Medical physics aspects of the synchrotron radiation therapies: Microbeam radiation therapy (MRT) and synchrotron stereotactic radiotherapy (SSRT).</title>
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<author><name sortKey="Adam, Jean Francois" sort="Adam, Jean Francois" uniqKey="Adam J" first="Jean-Francois" last="Adam">Jean-Francois Adam</name>
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<author><name sortKey="Alagoz, Enver" sort="Alagoz, Enver" uniqKey="Alagoz E" first="Enver" last="Alagoz">Enver Alagoz</name>
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<author><name sortKey="Crosbie, Jeff" sort="Crosbie, Jeff" uniqKey="Crosbie J" first="Jeff" last="Crosbie">Jeff Crosbie</name>
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<author><name sortKey="Dewagter, Carlos" sort="Dewagter, Carlos" uniqKey="Dewagter C" first="Carlos" last="Dewagter">Carlos Dewagter</name>
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<author><name sortKey="Dipuglia, Andrew" sort="Dipuglia, Andrew" uniqKey="Dipuglia A" first="Andrew" last="Dipuglia">Andrew Dipuglia</name>
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<author><name sortKey="Donzelli, Mattia" sort="Donzelli, Mattia" uniqKey="Donzelli M" first="Mattia" last="Donzelli">Mattia Donzelli</name>
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<author><name sortKey="Doran, Simon" sort="Doran, Simon" uniqKey="Doran S" first="Simon" last="Doran">Simon Doran</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>CRUK Cancer Imaging Centre, Institute of Cancer Research, 15 Cotswold Rd, Sutton Surrey</wicri:regionArea>
<wicri:noRegion>Sutton Surrey</wicri:noRegion>
</affiliation>
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<author><name sortKey="Fournier, Pauline" sort="Fournier, Pauline" uniqKey="Fournier P" first="Pauline" last="Fournier">Pauline Fournier</name>
<affiliation wicri:level="1"><nlm:affiliation>ESRF-The European Synchrotron, 71, Avenue des Martyrs, Grenoble, France; Centre for Medical Radiation Physics, University of Wollongong, Northfields Ave, NSW, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>ESRF-The European Synchrotron, 71, Avenue des Martyrs, Grenoble, France; Centre for Medical Radiation Physics, University of Wollongong, Northfields Ave, NSW</wicri:regionArea>
<wicri:noRegion>NSW</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kalef Ezra, John" sort="Kalef Ezra, John" uniqKey="Kalef Ezra J" first="John" last="Kalef-Ezra">John Kalef-Ezra</name>
<affiliation wicri:level="1"><nlm:affiliation>Medical Physics Laboratory, University of Ioannina, 451.10, Ioannina, Greece.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Medical Physics Laboratory, University of Ioannina, 451.10, Ioannina</wicri:regionArea>
<wicri:noRegion>Ioannina</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kock, Angela" sort="Kock, Angela" uniqKey="Kock A" first="Angela" last="Kock">Angela Kock</name>
<affiliation wicri:level="3"><nlm:affiliation>Sintef Minalab, Gaustadalléen 23C, 0373, Oslo, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Sintef Minalab, Gaustadalléen 23C, 0373, Oslo</wicri:regionArea>
<placeName><settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
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<front><div type="abstract" xml:lang="en">Stereotactic Synchrotron Radiotherapy (SSRT) and Microbeam Radiation Therapy (MRT) are both novel approaches to treat brain tumor and potentially other tumors using synchrotron radiation. Although the techniques differ by their principles, SSRT and MRT share certain common aspects with the possibility of combining their advantages in the future. For MRT, the technique uses highly collimated, quasi-parallel arrays of X-ray microbeams between 50 and 600 keV. Important features of highly brilliant Synchrotron sources are a very small beam divergence and an extremely high dose rate. The minimal beam divergence allows the insertion of so called Multi Slit Collimators (MSC) to produce spatially fractionated beams of typically ∼25-75 micron-wide microplanar beams separated by wider (100-400 microns center-to-center(ctc)) spaces with a very sharp penumbra. Peak entrance doses of several hundreds of Gy are extremely well tolerated by normal tissues and at the same time provide a higher therapeutic index for various tumor models in rodents. The hypothesis of a selective radio-vulnerability of the tumor vasculature versus normal blood vessels by MRT was recently more solidified. SSRT (Synchrotron Stereotactic Radiotherapy) is based on a local drug uptake of high-Z elements in tumors followed by stereotactic irradiation with 80 keV photons to enhance the dose deposition only within the tumor. With SSRT already in its clinical trial stage at the ESRF, most medical physics problems are already solved and the implemented solutions are briefly described, while the medical physics aspects in MRT will be discussed in more detail in this paper.</div>
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<ArticleTitle>Medical physics aspects of the synchrotron radiation therapies: Microbeam radiation therapy (MRT) and synchrotron stereotactic radiotherapy (SSRT).</ArticleTitle>
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<Abstract><AbstractText>Stereotactic Synchrotron Radiotherapy (SSRT) and Microbeam Radiation Therapy (MRT) are both novel approaches to treat brain tumor and potentially other tumors using synchrotron radiation. Although the techniques differ by their principles, SSRT and MRT share certain common aspects with the possibility of combining their advantages in the future. For MRT, the technique uses highly collimated, quasi-parallel arrays of X-ray microbeams between 50 and 600 keV. Important features of highly brilliant Synchrotron sources are a very small beam divergence and an extremely high dose rate. The minimal beam divergence allows the insertion of so called Multi Slit Collimators (MSC) to produce spatially fractionated beams of typically ∼25-75 micron-wide microplanar beams separated by wider (100-400 microns center-to-center(ctc)) spaces with a very sharp penumbra. Peak entrance doses of several hundreds of Gy are extremely well tolerated by normal tissues and at the same time provide a higher therapeutic index for various tumor models in rodents. The hypothesis of a selective radio-vulnerability of the tumor vasculature versus normal blood vessels by MRT was recently more solidified. SSRT (Synchrotron Stereotactic Radiotherapy) is based on a local drug uptake of high-Z elements in tumors followed by stereotactic irradiation with 80 keV photons to enhance the dose deposition only within the tumor. With SSRT already in its clinical trial stage at the ESRF, most medical physics problems are already solved and the implemented solutions are briefly described, while the medical physics aspects in MRT will be discussed in more detail in this paper.</AbstractText>
<CopyrightInformation>Copyright © 2015. Published by Elsevier Ltd.</CopyrightInformation>
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<li>Suède</li>
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<region><li>Auvergne-Rhône-Alpes</li>
<li>Province de Flandre-Orientale</li>
<li>Rhône-Alpes</li>
<li>Svealand</li>
<li>Østlandet</li>
</region>
<settlement><li>Gand</li>
<li>Grenoble</li>
<li>Oslo</li>
<li>Stockholm</li>
</settlement>
</list>
<tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Br Uer Krisch, Elke" sort="Br Uer Krisch, Elke" uniqKey="Br Uer Krisch E" first="Elke" last="Br Uer-Krisch">Elke Br Uer-Krisch</name>
</region>
<name sortKey="Adam, Jean Francois" sort="Adam, Jean Francois" uniqKey="Adam J" first="Jean-Francois" last="Adam">Jean-Francois Adam</name>
<name sortKey="Donzelli, Mattia" sort="Donzelli, Mattia" uniqKey="Donzelli M" first="Mattia" last="Donzelli">Mattia Donzelli</name>
</country>
<country name="Norvège"><noRegion><name sortKey="Alagoz, Enver" sort="Alagoz, Enver" uniqKey="Alagoz E" first="Enver" last="Alagoz">Enver Alagoz</name>
</noRegion>
<name sortKey="Kock, Angela" sort="Kock, Angela" uniqKey="Kock A" first="Angela" last="Kock">Angela Kock</name>
<name sortKey="Povoli, Marco" sort="Povoli, Marco" uniqKey="Povoli M" first="Marco" last="Povoli">Marco Povoli</name>
<name sortKey="Stugu, Bjarne" sort="Stugu, Bjarne" uniqKey="Stugu B" first="Bjarne" last="Stugu">Bjarne Stugu</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Bartzsch, Stefan" sort="Bartzsch, Stefan" uniqKey="Bartzsch S" first="Stefan" last="Bartzsch">Stefan Bartzsch</name>
</noRegion>
<name sortKey="Doran, Simon" sort="Doran, Simon" uniqKey="Doran S" first="Simon" last="Doran">Simon Doran</name>
<name sortKey="Mcerlean, Ciara" sort="Mcerlean, Ciara" uniqKey="Mcerlean C" first="Ciara" last="Mcerlean">Ciara Mcerlean</name>
<name sortKey="Oelfke, Uwe" sort="Oelfke, Uwe" uniqKey="Oelfke U" first="Uwe" last="Oelfke">Uwe Oelfke</name>
</country>
<country name="Australie"><noRegion><name sortKey="Crosbie, Jeff" sort="Crosbie, Jeff" uniqKey="Crosbie J" first="Jeff" last="Crosbie">Jeff Crosbie</name>
</noRegion>
<name sortKey="Dipuglia, Andrew" sort="Dipuglia, Andrew" uniqKey="Dipuglia A" first="Andrew" last="Dipuglia">Andrew Dipuglia</name>
<name sortKey="Fournier, Pauline" sort="Fournier, Pauline" uniqKey="Fournier P" first="Pauline" last="Fournier">Pauline Fournier</name>
<name sortKey="Lerch, Michael" sort="Lerch, Michael" uniqKey="Lerch M" first="Michael" last="Lerch">Michael Lerch</name>
<name sortKey="Petasecca, Marco" sort="Petasecca, Marco" uniqKey="Petasecca M" first="Marco" last="Petasecca">Marco Petasecca</name>
<name sortKey="Rosenfeld, Anatoly" sort="Rosenfeld, Anatoly" uniqKey="Rosenfeld A" first="Anatoly" last="Rosenfeld">Anatoly Rosenfeld</name>
</country>
<country name="Belgique"><region name="Province de Flandre-Orientale"><name sortKey="Dewagter, Carlos" sort="Dewagter, Carlos" uniqKey="Dewagter C" first="Carlos" last="Dewagter">Carlos Dewagter</name>
</region>
</country>
<country name="Grèce"><noRegion><name sortKey="Kalef Ezra, John" sort="Kalef Ezra, John" uniqKey="Kalef Ezra J" first="John" last="Kalef-Ezra">John Kalef-Ezra</name>
</noRegion>
</country>
<country name="Pologne"><noRegion><name sortKey="Olko, Pawel" sort="Olko, Pawel" uniqKey="Olko P" first="Pawel" last="Olko">Pawel Olko</name>
</noRegion>
</country>
<country name="Suède"><region name="Svealand"><name sortKey="Siegbahn, Erik A" sort="Siegbahn, Erik A" uniqKey="Siegbahn E" first="Erik A" last="Siegbahn">Erik A. Siegbahn</name>
</region>
</country>
<country name="Roumanie"><noRegion><name sortKey="Sporea, Dan" sort="Sporea, Dan" uniqKey="Sporea D" first="Dan" last="Sporea">Dan Sporea</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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   |texte=   Medical physics aspects of the synchrotron radiation therapies: Microbeam radiation therapy (MRT) and synchrotron stereotactic radiotherapy (SSRT).
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	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les relations entre la France et l'Australie

Medical physics aspects of the synchrotron radiation therapies: Microbeam radiation therapy (MRT) and synchrotron stereotactic radiotherapy (SSRT).

Medical physics aspects of the synchrotron radiation therapies: Microbeam radiation therapy (MRT) and synchrotron stereotactic radiotherapy (SSRT).

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