Promoting macrophage survival delays progression of pre-existing atherosclerotic lesions through macrophage-derived apoE.
Identifieur interne : 002790 ( PubMed/Checkpoint ); précédent : 002789; suivant : 002791Promoting macrophage survival delays progression of pre-existing atherosclerotic lesions through macrophage-derived apoE.
Auteurs : Laura Bouchareychas [France] ; John Pirault [France] ; Flora Saint-Charles [France] ; Virginie Deswaerte [France] ; Tiphaine Le Roy [France] ; Wendy Jessup [Australie] ; Philippe Giral [France] ; Wilfried Le Goff [France] ; Thierry Huby [France] ; Emmanuel L. Gautier [France] ; Philippe Lesnik [France]Source :
- Cardiovascular research [ 1755-3245 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Antigènes Ly (physiologie), Apolipoprotéines E (physiologie), Apoptose, Athérosclérose (étiologie), Cholestérol (métabolisme), Macrophages (physiologie), Mâle, Protéines proto-oncogènes c-bcl-2 (analyse), Récepteurs aux lipoprotéines LDL (physiologie), Souris, Survie cellulaire, Évolution de la maladie.
- MESH :
- analyse : Protéines proto-oncogènes c-bcl-2.
- métabolisme : Cholestérol.
- physiologie : Antigènes Ly, Apolipoprotéines E, Macrophages, Récepteurs aux lipoprotéines LDL.
- étiologie : Athérosclérose.
- Animaux, Apoptose, Mâle, Souris, Survie cellulaire, Évolution de la maladie.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Proto-Oncogene Proteins c-bcl-2.
- chemical , metabolism : Cholesterol.
- chemical , physiology : Antigens, Ly, Apolipoproteins E, Receptors, LDL.
- etiology : Atherosclerosis.
- physiology : Macrophages.
- Animals, Apoptosis, Cell Survival, Disease Progression, Male, Mice.
Abstract
Macrophage apoptosis is a prominent feature of atherosclerosis, yet whether cell death-protected macrophages would favour the resolution of already established atherosclerotic lesions, and thus hold therapeutic potential, remains unknown.
DOI: 10.1093/cvr/cvv177
PubMed: 26092098
Affiliations:
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pubmed:26092098Le document en format XML
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<author><name sortKey="Le Goff, Wilfried" sort="Le Goff, Wilfried" uniqKey="Le Goff W" first="Wilfried" last="Le Goff">Wilfried Le Goff</name>
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<author><name sortKey="Lesnik, Philippe" sort="Lesnik, Philippe" uniqKey="Lesnik P" first="Philippe" last="Lesnik">Philippe Lesnik</name>
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<series><title level="j">Cardiovascular research</title>
<idno type="eISSN">1755-3245</idno>
<imprint><date when="2015" type="published">2015</date>
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<term>Antigens, Ly (physiology)</term>
<term>Apolipoproteins E (physiology)</term>
<term>Apoptosis</term>
<term>Atherosclerosis (etiology)</term>
<term>Cell Survival</term>
<term>Cholesterol (metabolism)</term>
<term>Disease Progression</term>
<term>Macrophages (physiology)</term>
<term>Male</term>
<term>Mice</term>
<term>Proto-Oncogene Proteins c-bcl-2 (analysis)</term>
<term>Receptors, LDL (physiology)</term>
</keywords>
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<term>Antigènes Ly (physiologie)</term>
<term>Apolipoprotéines E (physiologie)</term>
<term>Apoptose</term>
<term>Athérosclérose (étiologie)</term>
<term>Cholestérol (métabolisme)</term>
<term>Macrophages (physiologie)</term>
<term>Mâle</term>
<term>Protéines proto-oncogènes c-bcl-2 (analyse)</term>
<term>Récepteurs aux lipoprotéines LDL (physiologie)</term>
<term>Souris</term>
<term>Survie cellulaire</term>
<term>Évolution de la maladie</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Proto-Oncogene Proteins c-bcl-2</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cholesterol</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Antigens, Ly</term>
<term>Apolipoproteins E</term>
<term>Receptors, LDL</term>
</keywords>
<keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Protéines proto-oncogènes c-bcl-2</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Atherosclerosis</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cholestérol</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Antigènes Ly</term>
<term>Apolipoprotéines E</term>
<term>Macrophages</term>
<term>Récepteurs aux lipoprotéines LDL</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Macrophages</term>
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<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Athérosclérose</term>
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<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Apoptosis</term>
<term>Cell Survival</term>
<term>Disease Progression</term>
<term>Male</term>
<term>Mice</term>
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<term>Apoptose</term>
<term>Mâle</term>
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<front><div type="abstract" xml:lang="en">Macrophage apoptosis is a prominent feature of atherosclerosis, yet whether cell death-protected macrophages would favour the resolution of already established atherosclerotic lesions, and thus hold therapeutic potential, remains unknown.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26092098</PMID>
<DateCreated><Year>2015</Year>
<Month>09</Month>
<Day>17</Day>
</DateCreated>
<DateCompleted><Year>2016</Year>
<Month>09</Month>
<Day>02</Day>
</DateCompleted>
<DateRevised><Year>2015</Year>
<Month>09</Month>
<Day>17</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1755-3245</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>108</Volume>
<Issue>1</Issue>
<PubDate><Year>2015</Year>
<Month>Oct</Month>
<Day>01</Day>
</PubDate>
</JournalIssue>
<Title>Cardiovascular research</Title>
<ISOAbbreviation>Cardiovasc. Res.</ISOAbbreviation>
</Journal>
<ArticleTitle>Promoting macrophage survival delays progression of pre-existing atherosclerotic lesions through macrophage-derived apoE.</ArticleTitle>
<Pagination><MedlinePgn>111-23</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1093/cvr/cvv177</ELocationID>
<Abstract><AbstractText Label="AIMS" NlmCategory="OBJECTIVE">Macrophage apoptosis is a prominent feature of atherosclerosis, yet whether cell death-protected macrophages would favour the resolution of already established atherosclerotic lesions, and thus hold therapeutic potential, remains unknown.</AbstractText>
<AbstractText Label="METHODS AND RESULTS" NlmCategory="RESULTS">We irradiated then transplanted into Apoe(-/-) or LDLr(-/-) recipient mice harbouring established atherosclerotic lesions, bone marrow cells from mice displaying enhanced macrophage survival through overexpression of the antiapoptotic gene hBcl-2 (Mø-hBcl2 Apoe(-/-) or Mø-hBcl2 Apoe(+/+) LDLr(-/-)). Both recipient mice exhibited decreased lesional apoptotic cell content and reduced necrotic areas when repopulated with Mø-hBcl2 mouse-derived bone marrow cells. In contrast, only LDLr(-/-) recipients showed a reduction in plasma cholesterol levels and in atherosclerotic lesions. The absence of significant reduction of plasma cholesterol levels in the context of apoE deficiency highlighted macrophage-derived apoE as key in both the regulation of plasma and tissue cholesterol levels and the progression of pre-existing lesion. Accordingly, hBcl2 expression in macrophages was associated with larger pools of Kupffer cells and Ly-6C(low) monocytes, both high producers of apoE. Additionally, increased Kupffer cells population was associated with improved clearance of apoptotic cells and modified lipoproteins.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Collectively, these data show that promoting macrophage survival provides a supplemental source of apoE, which hinders pre-existing plaque progression.</AbstractText>
<CopyrightInformation>Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2015. For permissions please email: journals.permissions@oup.com.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bouchareychas</LastName>
<ForeName>Laura</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Sorbonne Universités, UPMC Université Paris 06, UMR_S 1166, ICAN, Integrative Biology of Atherosclerosis Team, Paris F-75005, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pirault</LastName>
<ForeName>John</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Sorbonne Universités, UPMC Université Paris 06, UMR_S 1166, ICAN, Integrative Biology of Atherosclerosis Team, Paris F-75005, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Saint-Charles</LastName>
<ForeName>Flora</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Sorbonne Universités, UPMC Université Paris 06, UMR_S 1166, ICAN, Integrative Biology of Atherosclerosis Team, Paris F-75005, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Deswaerte</LastName>
<ForeName>Virginie</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Sorbonne Universités, UPMC Université Paris 06, UMR_S 1166, ICAN, Integrative Biology of Atherosclerosis Team, Paris F-75005, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Le Roy</LastName>
<ForeName>Tiphaine</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Institute of Cardiometabolism and Nutrition, ICAN, AP-HP, Pitié-Salpêtrière Hospital, Paris F-75013, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jessup</LastName>
<ForeName>Wendy</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Atherosclerosis Group, ANZAC Research Institute, University of Sydney and Concord Hospital, Sydney, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Giral</LastName>
<ForeName>Philippe</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Institute of Cardiometabolism and Nutrition, ICAN, AP-HP, Pitié-Salpêtrière Hospital, Paris F-75013, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Le Goff</LastName>
<ForeName>Wilfried</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Sorbonne Universités, UPMC Université Paris 06, UMR_S 1166, ICAN, Integrative Biology of Atherosclerosis Team, Paris F-75005, France Institute of Cardiometabolism and Nutrition, ICAN, AP-HP, Pitié-Salpêtrière Hospital, Paris F-75013, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Huby</LastName>
<ForeName>Thierry</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Sorbonne Universités, UPMC Université Paris 06, UMR_S 1166, ICAN, Integrative Biology of Atherosclerosis Team, Paris F-75005, France Institute of Cardiometabolism and Nutrition, ICAN, AP-HP, Pitié-Salpêtrière Hospital, Paris F-75013, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gautier</LastName>
<ForeName>Emmanuel L</ForeName>
<Initials>EL</Initials>
<AffiliationInfo><Affiliation>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Sorbonne Universités, UPMC Université Paris 06, UMR_S 1166, ICAN, Integrative Biology of Atherosclerosis Team, Paris F-75005, France Institute of Cardiometabolism and Nutrition, ICAN, AP-HP, Pitié-Salpêtrière Hospital, Paris F-75013, France philippe.lesnik@upmc.fr emmanuel-laurent.gautier@inserm.fr.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lesnik</LastName>
<ForeName>Philippe</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Sorbonne Universités, UPMC Université Paris 06, UMR_S 1166, ICAN, Integrative Biology of Atherosclerosis Team, Paris F-75005, France Institute of Cardiometabolism and Nutrition, ICAN, AP-HP, Pitié-Salpêtrière Hospital, Paris F-75013, France philippe.lesnik@upmc.fr emmanuel-laurent.gautier@inserm.fr.</Affiliation>
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</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2015</Year>
<Month>06</Month>
<Day>19</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Cardiovasc Res</MedlineTA>
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<li>France</li>
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<name sortKey="Deswaerte, Virginie" sort="Deswaerte, Virginie" uniqKey="Deswaerte V" first="Virginie" last="Deswaerte">Virginie Deswaerte</name>
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<name sortKey="Giral, Philippe" sort="Giral, Philippe" uniqKey="Giral P" first="Philippe" last="Giral">Philippe Giral</name>
<name sortKey="Huby, Thierry" sort="Huby, Thierry" uniqKey="Huby T" first="Thierry" last="Huby">Thierry Huby</name>
<name sortKey="Le Goff, Wilfried" sort="Le Goff, Wilfried" uniqKey="Le Goff W" first="Wilfried" last="Le Goff">Wilfried Le Goff</name>
<name sortKey="Le Roy, Tiphaine" sort="Le Roy, Tiphaine" uniqKey="Le Roy T" first="Tiphaine" last="Le Roy">Tiphaine Le Roy</name>
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<name sortKey="Pirault, John" sort="Pirault, John" uniqKey="Pirault J" first="John" last="Pirault">John Pirault</name>
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<country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Jessup, Wendy" sort="Jessup, Wendy" uniqKey="Jessup W" first="Wendy" last="Jessup">Wendy Jessup</name>
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