Promoting macrophage survival delays progression of pre-existing atherosclerotic lesions through macrophage-derived apoE.
Identifieur interne : 002790 ( PubMed/Checkpoint ); précédent : 002789; suivant : 002791Promoting macrophage survival delays progression of pre-existing atherosclerotic lesions through macrophage-derived apoE.
Auteurs : Laura Bouchareychas [France] ; John Pirault [France] ; Flora Saint-Charles [France] ; Virginie Deswaerte [France] ; Tiphaine Le Roy [France] ; Wendy Jessup [Australie] ; Philippe Giral [France] ; Wilfried Le Goff [France] ; Thierry Huby [France] ; Emmanuel L. Gautier [France] ; Philippe Lesnik [France]Source :
- Cardiovascular research [ 1755-3245 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Antigènes Ly (physiologie), Apolipoprotéines E (physiologie), Apoptose, Athérosclérose (étiologie), Cholestérol (métabolisme), Macrophages (physiologie), Mâle, Protéines proto-oncogènes c-bcl-2 (analyse), Récepteurs aux lipoprotéines LDL (physiologie), Souris, Survie cellulaire, Évolution de la maladie.
- MESH :
- analyse : Protéines proto-oncogènes c-bcl-2.
- métabolisme : Cholestérol.
- physiologie : Antigènes Ly, Apolipoprotéines E, Macrophages, Récepteurs aux lipoprotéines LDL.
- étiologie : Athérosclérose.
- Animaux, Apoptose, Mâle, Souris, Survie cellulaire, Évolution de la maladie.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Proto-Oncogene Proteins c-bcl-2.
- chemical , metabolism : Cholesterol.
- chemical , physiology : Antigens, Ly, Apolipoproteins E, Receptors, LDL.
- etiology : Atherosclerosis.
- physiology : Macrophages.
- Animals, Apoptosis, Cell Survival, Disease Progression, Male, Mice.
Abstract
Macrophage apoptosis is a prominent feature of atherosclerosis, yet whether cell death-protected macrophages would favour the resolution of already established atherosclerotic lesions, and thus hold therapeutic potential, remains unknown.
DOI: 10.1093/cvr/cvv177
PubMed: 26092098
Affiliations:
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pubmed:26092098Le document en format XML
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nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Jessup, Wendy" sort="Jessup, Wendy" uniqKey="Jessup W" first="Wendy" last="Jessup">Wendy Jessup</name><affiliation wicri:level="3"><nlm:affiliation>Atherosclerosis Group, ANZAC Research Institute, University of Sydney and Concord Hospital, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Atherosclerosis Group, ANZAC Research Institute, University of Sydney and Concord Hospital, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Giral, Philippe" sort="Giral, Philippe" uniqKey="Giral P" first="Philippe" last="Giral">Philippe Giral</name><affiliation wicri:level="3"><nlm:affiliation>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Institute of Cardiometabolism and Nutrition, ICAN, AP-HP, Pitié-Salpêtrière Hospital, Paris F-75013, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Institute of Cardiometabolism and Nutrition, ICAN, AP-HP, Pitié-Salpêtrière Hospital, Paris F-75013</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Le Goff, Wilfried" sort="Le Goff, Wilfried" uniqKey="Le Goff W" first="Wilfried" last="Le Goff">Wilfried Le Goff</name><affiliation wicri:level="3"><nlm:affiliation>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Sorbonne Universités, UPMC Université Paris 06, 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F-75013</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Lesnik, Philippe" sort="Lesnik, Philippe" uniqKey="Lesnik P" first="Philippe" last="Lesnik">Philippe Lesnik</name><affiliation wicri:level="3"><nlm:affiliation>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Sorbonne Universités, UPMC Université Paris 06, UMR_S 1166, ICAN, Integrative Biology of Atherosclerosis Team, Paris F-75005, France Institute of Cardiometabolism and Nutrition, ICAN, AP-HP, Pitié-Salpêtrière Hospital, Paris F-75013, France philippe.lesnik@upmc.fr emmanuel-laurent.gautier@inserm.fr.</nlm:affiliation><country wicri:rule="url">France</country><wicri:regionArea>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Sorbonne Universités, UPMC Université Paris 06, UMR_S 1166, ICAN, Integrative Biology of Atherosclerosis Team, Paris F-75005, France Institute of Cardiometabolism and Nutrition, ICAN, AP-HP, Pitié-Salpêtrière Hospital, Paris F-75013</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26092098</idno><idno type="pmid">26092098</idno><idno type="doi">10.1093/cvr/cvv177</idno><idno type="wicri:Area/PubMed/Corpus">002912</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002912</idno><idno type="wicri:Area/PubMed/Curation">002843</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002843</idno><idno type="wicri:Area/PubMed/Checkpoint">002843</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" 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UPMC Université Paris 06, UMR_S 1166, ICAN, Integrative Biology of Atherosclerosis Team, Paris F-75005</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Pirault, John" sort="Pirault, John" uniqKey="Pirault J" first="John" last="Pirault">John Pirault</name><affiliation wicri:level="3"><nlm:affiliation>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Sorbonne Universités, UPMC Université Paris 06, UMR_S 1166, ICAN, Integrative Biology of Atherosclerosis Team, Paris F-75005, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Sorbonne Universités, UPMC Université Paris 06, UMR_S 1166, ICAN, Integrative Biology of Atherosclerosis Team, Paris F-75005</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Saint Charles, Flora" sort="Saint Charles, Flora" uniqKey="Saint Charles F" first="Flora" last="Saint-Charles">Flora Saint-Charles</name><affiliation wicri:level="3"><nlm:affiliation>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Sorbonne Universités, UPMC Université Paris 06, UMR_S 1166, ICAN, Integrative Biology of Atherosclerosis Team, Paris F-75005, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Sorbonne Universités, UPMC Université Paris 06, UMR_S 1166, ICAN, Integrative Biology of Atherosclerosis Team, Paris F-75005</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Deswaerte, Virginie" sort="Deswaerte, Virginie" uniqKey="Deswaerte V" first="Virginie" last="Deswaerte">Virginie Deswaerte</name><affiliation wicri:level="3"><nlm:affiliation>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Sorbonne Universités, UPMC Université Paris 06, UMR_S 1166, ICAN, Integrative Biology of Atherosclerosis Team, Paris F-75005, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Sorbonne Universités, UPMC Université Paris 06, UMR_S 1166, ICAN, Integrative Biology of Atherosclerosis Team, Paris F-75005</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Le Roy, Tiphaine" sort="Le Roy, Tiphaine" uniqKey="Le Roy T" first="Tiphaine" last="Le Roy">Tiphaine Le Roy</name><affiliation wicri:level="3"><nlm:affiliation>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Institute of Cardiometabolism and Nutrition, ICAN, AP-HP, Pitié-Salpêtrière Hospital, Paris F-75013, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Institute of Cardiometabolism and Nutrition, ICAN, AP-HP, Pitié-Salpêtrière Hospital, Paris F-75013</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Jessup, Wendy" sort="Jessup, Wendy" uniqKey="Jessup W" first="Wendy" last="Jessup">Wendy Jessup</name><affiliation wicri:level="3"><nlm:affiliation>Atherosclerosis Group, ANZAC Research Institute, University of Sydney and Concord Hospital, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Atherosclerosis Group, ANZAC Research Institute, University of Sydney and Concord Hospital, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Giral, Philippe" sort="Giral, Philippe" uniqKey="Giral P" first="Philippe" last="Giral">Philippe Giral</name><affiliation wicri:level="3"><nlm:affiliation>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Institute of Cardiometabolism and Nutrition, ICAN, AP-HP, Pitié-Salpêtrière Hospital, Paris F-75013, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Institute of Cardiometabolism and Nutrition, ICAN, AP-HP, Pitié-Salpêtrière Hospital, Paris F-75013</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Le Goff, Wilfried" sort="Le Goff, Wilfried" uniqKey="Le Goff W" first="Wilfried" last="Le Goff">Wilfried Le Goff</name><affiliation wicri:level="3"><nlm:affiliation>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Sorbonne Universités, UPMC Université Paris 06, UMR_S 1166, ICAN, Integrative Biology of Atherosclerosis Team, Paris F-75005, France Institute of Cardiometabolism and Nutrition, ICAN, AP-HP, Pitié-Salpêtrière Hospital, Paris F-75013, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Sorbonne Universités, UPMC Université Paris 06, UMR_S 1166, ICAN, Integrative Biology of Atherosclerosis Team, Paris F-75005, France Institute of Cardiometabolism and Nutrition, ICAN, AP-HP, Pitié-Salpêtrière Hospital, Paris F-75013</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Huby, Thierry" sort="Huby, Thierry" uniqKey="Huby T" first="Thierry" last="Huby">Thierry Huby</name><affiliation wicri:level="3"><nlm:affiliation>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Sorbonne Universités, UPMC Université Paris 06, UMR_S 1166, ICAN, Integrative Biology of Atherosclerosis Team, Paris F-75005, France Institute of Cardiometabolism and Nutrition, ICAN, AP-HP, Pitié-Salpêtrière Hospital, Paris F-75013, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Sorbonne Universités, UPMC Université Paris 06, UMR_S 1166, ICAN, Integrative Biology of Atherosclerosis Team, Paris F-75005, France Institute of Cardiometabolism and Nutrition, ICAN, AP-HP, Pitié-Salpêtrière Hospital, Paris F-75013</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Gautier, Emmanuel L" sort="Gautier, Emmanuel L" uniqKey="Gautier E" first="Emmanuel L" last="Gautier">Emmanuel L. Gautier</name><affiliation wicri:level="3"><nlm:affiliation>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Sorbonne Universités, UPMC Université Paris 06, UMR_S 1166, ICAN, Integrative Biology of Atherosclerosis Team, Paris F-75005, France Institute of Cardiometabolism and Nutrition, ICAN, AP-HP, Pitié-Salpêtrière Hospital, Paris F-75013, France philippe.lesnik@upmc.fr emmanuel-laurent.gautier@inserm.fr.</nlm:affiliation><country wicri:rule="url">France</country><wicri:regionArea>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Sorbonne Universités, UPMC Université Paris 06, UMR_S 1166, ICAN, Integrative Biology of Atherosclerosis Team, Paris F-75005, France Institute of Cardiometabolism and Nutrition, ICAN, AP-HP, Pitié-Salpêtrière Hospital, Paris F-75013</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Lesnik, Philippe" sort="Lesnik, Philippe" uniqKey="Lesnik P" first="Philippe" last="Lesnik">Philippe Lesnik</name><affiliation wicri:level="3"><nlm:affiliation>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Sorbonne Universités, UPMC Université Paris 06, UMR_S 1166, ICAN, Integrative Biology of Atherosclerosis Team, Paris F-75005, France Institute of Cardiometabolism and Nutrition, ICAN, AP-HP, Pitié-Salpêtrière Hospital, Paris F-75013, France philippe.lesnik@upmc.fr emmanuel-laurent.gautier@inserm.fr.</nlm:affiliation><country wicri:rule="url">France</country><wicri:regionArea>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Sorbonne Universités, UPMC Université Paris 06, UMR_S 1166, ICAN, Integrative Biology of Atherosclerosis Team, Paris F-75005, France Institute of Cardiometabolism and Nutrition, ICAN, AP-HP, Pitié-Salpêtrière Hospital, Paris F-75013</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author></analytic><series><title level="j">Cardiovascular research</title><idno type="eISSN">1755-3245</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antigens, Ly (physiology)</term><term>Apolipoproteins E (physiology)</term><term>Apoptosis</term><term>Atherosclerosis (etiology)</term><term>Cell Survival</term><term>Cholesterol (metabolism)</term><term>Disease Progression</term><term>Macrophages (physiology)</term><term>Male</term><term>Mice</term><term>Proto-Oncogene Proteins c-bcl-2 (analysis)</term><term>Receptors, LDL (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antigènes Ly (physiologie)</term><term>Apolipoprotéines E (physiologie)</term><term>Apoptose</term><term>Athérosclérose (étiologie)</term><term>Cholestérol (métabolisme)</term><term>Macrophages (physiologie)</term><term>Mâle</term><term>Protéines proto-oncogènes c-bcl-2 (analyse)</term><term>Récepteurs aux lipoprotéines LDL (physiologie)</term><term>Souris</term><term>Survie cellulaire</term><term>Évolution de la maladie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Proto-Oncogene Proteins c-bcl-2</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cholesterol</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Antigens, Ly</term><term>Apolipoproteins E</term><term>Receptors, LDL</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Protéines proto-oncogènes c-bcl-2</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Atherosclerosis</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cholestérol</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Antigènes Ly</term><term>Apolipoprotéines E</term><term>Macrophages</term><term>Récepteurs aux lipoprotéines LDL</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Macrophages</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Athérosclérose</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Apoptosis</term><term>Cell Survival</term><term>Disease Progression</term><term>Male</term><term>Mice</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Apoptose</term><term>Mâle</term><term>Souris</term><term>Survie cellulaire</term><term>Évolution de la maladie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Macrophage apoptosis is a prominent feature of atherosclerosis, yet whether cell death-protected macrophages would favour the resolution of already established atherosclerotic lesions, and thus hold therapeutic potential, remains unknown.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26092098</PMID><DateCreated><Year>2015</Year><Month>09</Month><Day>17</Day></DateCreated><DateCompleted><Year>2016</Year><Month>09</Month><Day>02</Day></DateCompleted><DateRevised><Year>2015</Year><Month>09</Month><Day>17</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1755-3245</ISSN><JournalIssue CitedMedium="Internet"><Volume>108</Volume><Issue>1</Issue><PubDate><Year>2015</Year><Month>Oct</Month><Day>01</Day></PubDate></JournalIssue><Title>Cardiovascular research</Title><ISOAbbreviation>Cardiovasc. Res.</ISOAbbreviation></Journal><ArticleTitle>Promoting macrophage survival delays progression of pre-existing atherosclerotic lesions through macrophage-derived apoE.</ArticleTitle><Pagination><MedlinePgn>111-23</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/cvr/cvv177</ELocationID><Abstract><AbstractText Label="AIMS" NlmCategory="OBJECTIVE">Macrophage apoptosis is a prominent feature of atherosclerosis, yet whether cell death-protected macrophages would favour the resolution of already established atherosclerotic lesions, and thus hold therapeutic potential, remains unknown.</AbstractText><AbstractText Label="METHODS AND RESULTS" NlmCategory="RESULTS">We irradiated then transplanted into Apoe(-/-) or LDLr(-/-) recipient mice harbouring established atherosclerotic lesions, bone marrow cells from mice displaying enhanced macrophage survival through overexpression of the antiapoptotic gene hBcl-2 (Mø-hBcl2 Apoe(-/-) or Mø-hBcl2 Apoe(+/+) LDLr(-/-)). Both recipient mice exhibited decreased lesional apoptotic cell content and reduced necrotic areas when repopulated with Mø-hBcl2 mouse-derived bone marrow cells. In contrast, only LDLr(-/-) recipients showed a reduction in plasma cholesterol levels and in atherosclerotic lesions. The absence of significant reduction of plasma cholesterol levels in the context of apoE deficiency highlighted macrophage-derived apoE as key in both the regulation of plasma and tissue cholesterol levels and the progression of pre-existing lesion. Accordingly, hBcl2 expression in macrophages was associated with larger pools of Kupffer cells and Ly-6C(low) monocytes, both high producers of apoE. Additionally, increased Kupffer cells population was associated with improved clearance of apoptotic cells and modified lipoproteins.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Collectively, these data show that promoting macrophage survival provides a supplemental source of apoE, which hinders pre-existing plaque progression.</AbstractText><CopyrightInformation>Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2015. For permissions please email: journals.permissions@oup.com.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bouchareychas</LastName><ForeName>Laura</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Sorbonne Universités, UPMC Université Paris 06, UMR_S 1166, ICAN, Integrative Biology of Atherosclerosis Team, Paris F-75005, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pirault</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Sorbonne Universités, UPMC Université Paris 06, UMR_S 1166, ICAN, Integrative Biology of Atherosclerosis Team, Paris F-75005, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Saint-Charles</LastName><ForeName>Flora</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Sorbonne Universités, UPMC Université Paris 06, UMR_S 1166, ICAN, Integrative Biology of Atherosclerosis Team, Paris F-75005, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deswaerte</LastName><ForeName>Virginie</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Sorbonne Universités, UPMC Université Paris 06, UMR_S 1166, ICAN, Integrative Biology of Atherosclerosis Team, Paris F-75005, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Le Roy</LastName><ForeName>Tiphaine</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Institute of Cardiometabolism and Nutrition, ICAN, AP-HP, Pitié-Salpêtrière Hospital, Paris F-75013, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jessup</LastName><ForeName>Wendy</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Atherosclerosis Group, ANZAC Research Institute, University of Sydney and Concord Hospital, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giral</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Institute of Cardiometabolism and Nutrition, ICAN, AP-HP, Pitié-Salpêtrière Hospital, Paris F-75013, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Le Goff</LastName><ForeName>Wilfried</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Sorbonne Universités, UPMC Université Paris 06, UMR_S 1166, ICAN, Integrative Biology of Atherosclerosis Team, Paris F-75005, France Institute of Cardiometabolism and Nutrition, ICAN, AP-HP, Pitié-Salpêtrière Hospital, Paris F-75013, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huby</LastName><ForeName>Thierry</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Sorbonne Universités, UPMC Université Paris 06, UMR_S 1166, ICAN, Integrative Biology of Atherosclerosis Team, Paris F-75005, France Institute of Cardiometabolism and Nutrition, ICAN, AP-HP, Pitié-Salpêtrière Hospital, Paris F-75013, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gautier</LastName><ForeName>Emmanuel L</ForeName><Initials>EL</Initials><AffiliationInfo><Affiliation>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Sorbonne Universités, UPMC Université Paris 06, UMR_S 1166, ICAN, Integrative Biology of Atherosclerosis Team, Paris F-75005, France Institute of Cardiometabolism and Nutrition, ICAN, AP-HP, Pitié-Salpêtrière Hospital, Paris F-75013, France philippe.lesnik@upmc.fr emmanuel-laurent.gautier@inserm.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lesnik</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>INSERM, UMR_S U1166, Integrative Biology of Atherosclerosis Team, Hôpital de la Pitié, Pavillon Benjamin Delessert, 83 Boulevard de L'hôpital, Paris F-75013, France Sorbonne Universités, UPMC Université Paris 06, UMR_S 1166, ICAN, Integrative Biology of Atherosclerosis Team, Paris F-75005, France Institute of Cardiometabolism and Nutrition, ICAN, AP-HP, Pitié-Salpêtrière Hospital, Paris F-75013, France philippe.lesnik@upmc.fr emmanuel-laurent.gautier@inserm.fr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>06</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Cardiovasc Res</MedlineTA><NlmUniqueID>0077427</NlmUniqueID><ISSNLinking>0008-6363</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000950">Antigens, Ly</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001057">Apolipoproteins E</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C494192">Ly-6C antigen, mouse</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019253">Proto-Oncogene Proteins c-bcl-2</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011973">Receptors, LDL</NameOfSubstance></Chemical><Chemical><RegistryNumber>97C5T2UQ7J</RegistryNumber><NameOfSubstance UI="D002784">Cholesterol</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000950" MajorTopicYN="N">Antigens, Ly</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001057" MajorTopicYN="N">Apolipoproteins E</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017209" MajorTopicYN="N">Apoptosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D050197" MajorTopicYN="N">Atherosclerosis</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002470" MajorTopicYN="N">Cell Survival</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002784" MajorTopicYN="N">Cholesterol</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018450" MajorTopicYN="N">Disease Progression</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008264" MajorTopicYN="N">Macrophages</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019253" MajorTopicYN="N">Proto-Oncogene Proteins c-bcl-2</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011973" MajorTopicYN="N">Receptors, LDL</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Apolipoprotein E</Keyword><Keyword MajorTopicYN="N">Apoptosis</Keyword><Keyword MajorTopicYN="N">Atherosclerosis</Keyword><Keyword MajorTopicYN="N">Cholesterol</Keyword><Keyword MajorTopicYN="N">Macrophage</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>04</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>06</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>6</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>6</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>9</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26092098</ArticleId><ArticleId IdType="pii">cvv177</ArticleId><ArticleId IdType="doi">10.1093/cvr/cvv177</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Nouvelle-Galles du Sud</li><li>Île-de-France</li></region><settlement><li>Sydney</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Bouchareychas, Laura" sort="Bouchareychas, Laura" uniqKey="Bouchareychas L" first="Laura" last="Bouchareychas">Laura Bouchareychas</name></region><name sortKey="Deswaerte, Virginie" sort="Deswaerte, Virginie" uniqKey="Deswaerte V" first="Virginie" last="Deswaerte">Virginie Deswaerte</name><name sortKey="Gautier, Emmanuel L" sort="Gautier, Emmanuel L" uniqKey="Gautier E" first="Emmanuel L" last="Gautier">Emmanuel L. Gautier</name><name sortKey="Giral, Philippe" sort="Giral, Philippe" uniqKey="Giral P" first="Philippe" last="Giral">Philippe Giral</name><name sortKey="Huby, Thierry" sort="Huby, Thierry" uniqKey="Huby T" first="Thierry" last="Huby">Thierry Huby</name><name sortKey="Le Goff, Wilfried" sort="Le Goff, Wilfried" uniqKey="Le Goff W" first="Wilfried" last="Le Goff">Wilfried Le Goff</name><name sortKey="Le Roy, Tiphaine" sort="Le Roy, Tiphaine" uniqKey="Le Roy T" first="Tiphaine" last="Le Roy">Tiphaine Le Roy</name><name sortKey="Lesnik, Philippe" sort="Lesnik, Philippe" uniqKey="Lesnik P" first="Philippe" last="Lesnik">Philippe Lesnik</name><name sortKey="Pirault, John" sort="Pirault, John" uniqKey="Pirault J" first="John" last="Pirault">John Pirault</name><name sortKey="Saint Charles, Flora" sort="Saint Charles, Flora" uniqKey="Saint Charles F" first="Flora" last="Saint-Charles">Flora Saint-Charles</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Jessup, Wendy" sort="Jessup, Wendy" uniqKey="Jessup W" first="Wendy" last="Jessup">Wendy Jessup</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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