The background and rationale for a new fixed-dose combination for first-line treatment of tuberculosis in children.
Identifieur interne : 002586 ( PubMed/Checkpoint ); précédent : 002585; suivant : 002587The background and rationale for a new fixed-dose combination for first-line treatment of tuberculosis in children.
Auteurs : S M Graham [Australie] ; M. Grzemska [Suisse] ; R P Gie [Afrique du Sud]Source :
- The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease [ 1815-7920 ] ; 2015.
Descripteurs français
- KwdFr :
- Antituberculeux (administration et posologie), Association de médicaments, Enfant, Guides de bonnes pratiques cliniques comme sujet, Humains, Isoniazide (administration et posologie), Organisation mondiale de la santé, Poids du corps, Pyrazinamide (administration et posologie), Rifampicine (administration et posologie), Tuberculose (traitement médicamenteux), Éthambutol (administration et posologie).
- MESH :
- administration et posologie : Antituberculeux, Isoniazide, Pyrazinamide, Rifampicine, Éthambutol.
- traitement médicamenteux : Tuberculose.
- Association de médicaments, Enfant, Guides de bonnes pratiques cliniques comme sujet, Humains, Organisation mondiale de la santé, Poids du corps.
English descriptors
- KwdEn :
- Antitubercular Agents (administration & dosage), Body Weight, Child, Drug Therapy, Combination, Ethambutol (administration & dosage), Humans, Isoniazid (administration & dosage), Practice Guidelines as Topic, Pyrazinamide (administration & dosage), Rifampin (administration & dosage), Tuberculosis (drug therapy), World Health Organization.
- MESH :
- chemical , administration & dosage : Antitubercular Agents, Ethambutol, Isoniazid, Pyrazinamide, Rifampin.
- drug therapy : Tuberculosis.
- Body Weight, Child, Drug Therapy, Combination, Humans, Practice Guidelines as Topic, World Health Organization.
Abstract
In 2010, the World Health Organization revised the recommendations for the treatment of tuberculosis (TB) in children. The major revision was to increase isoniazid, rifampicin and pyrazinamide dosages according to body weight in children. The recommendations for higher dosages are based on consistent evidence from 1) pharmacokinetic studies suggesting that young children require higher dosages than adolescents and adults to achieve desired serum concentrations; and 2) observational studies reporting that the higher dosages would not be associated with increased risk of toxicity in children. However, national tuberculosis programmes faced unforeseen challenges in implementing the revised recommendations. The main difficulty was to adapt the revised dosages for the treatment of children with drug-susceptible TB using available fixed-dose combinations (FDCs). A more suitable FDC for the intensive and continuation phases of treatment has now been developed for planned implementation in 2015. This paper explains the background and rationale for the development of a new FDC tablet for children with drug-susceptible TB.
DOI: 10.5588/ijtld.15.0416
PubMed: 26564534
Affiliations:
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pubmed:26564534Le document en format XML
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<front><div type="abstract" xml:lang="en">In 2010, the World Health Organization revised the recommendations for the treatment of tuberculosis (TB) in children. The major revision was to increase isoniazid, rifampicin and pyrazinamide dosages according to body weight in children. The recommendations for higher dosages are based on consistent evidence from 1) pharmacokinetic studies suggesting that young children require higher dosages than adolescents and adults to achieve desired serum concentrations; and 2) observational studies reporting that the higher dosages would not be associated with increased risk of toxicity in children. However, national tuberculosis programmes faced unforeseen challenges in implementing the revised recommendations. The main difficulty was to adapt the revised dosages for the treatment of children with drug-susceptible TB using available fixed-dose combinations (FDCs). A more suitable FDC for the intensive and continuation phases of treatment has now been developed for planned implementation in 2015. This paper explains the background and rationale for the development of a new FDC tablet for children with drug-susceptible TB.</div>
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