Bimodal behaviour of interfollicular epidermal progenitors regulated by hair follicle position and cycling.
Identifieur interne : 002264 ( PubMed/Checkpoint ); précédent : 002263; suivant : 002265Bimodal behaviour of interfollicular epidermal progenitors regulated by hair follicle position and cycling.
Auteurs : Edwige Roy [Australie] ; Zoltan Neufeld [Australie] ; Luca Cerone [Australie] ; Ho Yi Wong [Australie] ; Samantha Hodgson [Australie] ; Jean Livet [France] ; Kiarash Khosrotehrani [Australie]Source :
- The EMBO journal [ 1460-2075 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- cytologie : Follicule pileux, Peau, Épiderme.
- physiologie : Cellules souches, Kératinocytes.
- Analyse spatio-temporelle, Animaux, Différenciation cellulaire, Modèles théoriques, Prolifération cellulaire, Souris, Techniques cytologiques.
English descriptors
- KwdEn :
- MESH :
- cytology : Epidermis, Hair Follicle, Skin.
- physiology : Keratinocytes, Stem Cells.
- Animals, Cell Differentiation, Cell Proliferation, Cytological Techniques, Mice, Models, Theoretical, Spatio-Temporal Analysis.
Abstract
Interfollicular epidermal (IFE) homeostasis is a major physiological process allowing maintenance of the skin barrier function. Despite progress in our understanding of stem cell populations in different hair follicle compartments, cellular mechanisms of IFE maintenance, in particular, whether a hierarchy of progenitors exists within this compartment, have remained controversial. We here used multicolour lineage tracing with Brainbow transgenic labels activated in the epidermis to track individual keratinocyte clones. Two modes of clonal progression could be observed in the adult murine dorsal skin. Clones attached to hair follicles showed rapid increase in size during the growth phase of the hair cycle. On the other hand, clones distant from hair follicles were slow cycling, but could be mobilized by a proliferative stimulus. Reinforced by mathematical modelling, these data support a model where progenitor cycling characteristics are differentially regulated in areas surrounding or away from growing hair follicles. Thus, while IFE progenitors follow a non-hierarchical mode of development, spatiotemporal control by their environment can change their potentialities, with far-reaching implications for epidermal homeostasis, wound repair and cancer development.
DOI: 10.15252/embj.201693806
PubMed: 27797819
Affiliations:
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pubmed:27797819Le document en format XML
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xml:lang="fr">France</country><wicri:regionArea>Sorbonne Universités, INSERM, CNRS, Institut de la Vision UPMC Univ Paris 06, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Khosrotehrani, Kiarash" sort="Khosrotehrani, Kiarash" uniqKey="Khosrotehrani K" first="Kiarash" last="Khosrotehrani">Kiarash Khosrotehrani</name><affiliation wicri:level="1"><nlm:affiliation>UQ Centre for Clinical Research, Experimental Dermatology Group, The University of Queensland, Brisbane, Qld, Australia k.khosrotehrani@uq.edu.au.</nlm:affiliation><country wicri:rule="url">Australie</country><wicri:regionArea>UQ Centre for Clinical Research, Experimental Dermatology Group, The University of Queensland, Brisbane, Qld</wicri:regionArea><wicri:noRegion>Qld</wicri:noRegion></affiliation></author></analytic><series><title level="j">The EMBO journal</title><idno type="eISSN">1460-2075</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cell Differentiation</term><term>Cell Proliferation</term><term>Cytological Techniques</term><term>Epidermis (cytology)</term><term>Hair Follicle (cytology)</term><term>Keratinocytes (physiology)</term><term>Mice</term><term>Models, Theoretical</term><term>Skin (cytology)</term><term>Spatio-Temporal Analysis</term><term>Stem Cells (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse spatio-temporelle</term><term>Animaux</term><term>Cellules souches (physiologie)</term><term>Différenciation cellulaire</term><term>Follicule pileux (cytologie)</term><term>Kératinocytes (physiologie)</term><term>Modèles théoriques</term><term>Peau (cytologie)</term><term>Prolifération cellulaire</term><term>Souris</term><term>Techniques cytologiques</term><term>Épiderme (cytologie)</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Follicule pileux</term><term>Peau</term><term>Épiderme</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Epidermis</term><term>Hair Follicle</term><term>Skin</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Cellules souches</term><term>Kératinocytes</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Keratinocytes</term><term>Stem Cells</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Differentiation</term><term>Cell Proliferation</term><term>Cytological Techniques</term><term>Mice</term><term>Models, Theoretical</term><term>Spatio-Temporal Analysis</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse spatio-temporelle</term><term>Animaux</term><term>Différenciation cellulaire</term><term>Modèles théoriques</term><term>Prolifération cellulaire</term><term>Souris</term><term>Techniques cytologiques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Interfollicular epidermal (IFE) homeostasis is a major physiological process allowing maintenance of the skin barrier function. Despite progress in our understanding of stem cell populations in different hair follicle compartments, cellular mechanisms of IFE maintenance, in particular, whether a hierarchy of progenitors exists within this compartment, have remained controversial. We here used multicolour lineage tracing with Brainbow transgenic labels activated in the epidermis to track individual keratinocyte clones. Two modes of clonal progression could be observed in the adult murine dorsal skin. Clones attached to hair follicles showed rapid increase in size during the growth phase of the hair cycle. On the other hand, clones distant from hair follicles were slow cycling, but could be mobilized by a proliferative stimulus. Reinforced by mathematical modelling, these data support a model where progenitor cycling characteristics are differentially regulated in areas surrounding or away from growing hair follicles. Thus, while IFE progenitors follow a non-hierarchical mode of development, spatiotemporal control by their environment can change their potentialities, with far-reaching implications for epidermal homeostasis, wound repair and cancer development.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27797819</PMID><DateCreated><Year>2016</Year><Month>10</Month><Day>31</Day></DateCreated><DateCompleted><Year>2017</Year><Month>07</Month><Day>05</Day></DateCompleted><DateRevised><Year>2017</Year><Month>07</Month><Day>05</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1460-2075</ISSN><JournalIssue CitedMedium="Internet"><Volume>35</Volume><Issue>24</Issue><PubDate><Year>2016</Year><Month>Dec</Month><Day>15</Day></PubDate></JournalIssue><Title>The EMBO journal</Title><ISOAbbreviation>EMBO J.</ISOAbbreviation></Journal><ArticleTitle>Bimodal behaviour of interfollicular epidermal progenitors regulated by hair follicle position and cycling.</ArticleTitle><Pagination><MedlinePgn>2658-2670</MedlinePgn></Pagination><Abstract><AbstractText>Interfollicular epidermal (IFE) homeostasis is a major physiological process allowing maintenance of the skin barrier function. Despite progress in our understanding of stem cell populations in different hair follicle compartments, cellular mechanisms of IFE maintenance, in particular, whether a hierarchy of progenitors exists within this compartment, have remained controversial. We here used multicolour lineage tracing with Brainbow transgenic labels activated in the epidermis to track individual keratinocyte clones. Two modes of clonal progression could be observed in the adult murine dorsal skin. Clones attached to hair follicles showed rapid increase in size during the growth phase of the hair cycle. On the other hand, clones distant from hair follicles were slow cycling, but could be mobilized by a proliferative stimulus. Reinforced by mathematical modelling, these data support a model where progenitor cycling characteristics are differentially regulated in areas surrounding or away from growing hair follicles. Thus, while IFE progenitors follow a non-hierarchical mode of development, spatiotemporal control by their environment can change their potentialities, with far-reaching implications for epidermal homeostasis, wound repair and cancer development.</AbstractText><CopyrightInformation>© 2016 The Authors.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Roy</LastName><ForeName>Edwige</ForeName><Initials>E</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-1991-5844</Identifier><AffiliationInfo><Affiliation>UQ Centre for Clinical Research, Experimental Dermatology Group, The University of Queensland, Brisbane, Qld, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Neufeld</LastName><ForeName>Zoltan</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>School of Mathematics and Physics, The University of Queensland, Brisbane, Qld, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cerone</LastName><ForeName>Luca</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>School of Mathematics and Physics, The University of Queensland, Brisbane, Qld, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wong</LastName><ForeName>Ho Yi</ForeName><Initials>HY</Initials><AffiliationInfo><Affiliation>UQ Centre for Clinical Research, Experimental Dermatology Group, The University of Queensland, Brisbane, Qld, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hodgson</LastName><ForeName>Samantha</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>UQ Centre for Clinical Research, Experimental Dermatology Group, The University of Queensland, Brisbane, Qld, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Livet</LastName><ForeName>Jean</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Sorbonne Universités, INSERM, CNRS, Institut de la Vision UPMC Univ Paris 06, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khosrotehrani</LastName><ForeName>Kiarash</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>UQ Centre for Clinical Research, Experimental Dermatology Group, The University of Queensland, Brisbane, Qld, Australia k.khosrotehrani@uq.edu.au.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>UQ Diamantina Institute, Translational Research Institute, The University of Queensland, Brisbane, Qld, Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>10</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>EMBO 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Mar;77(3 Pt 1):031907</RefSource><PMID Version="1">18517422</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002454" MajorTopicYN="N">Cell Differentiation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D049109" MajorTopicYN="Y">Cell Proliferation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003584" MajorTopicYN="N">Cytological Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004817" MajorTopicYN="N">Epidermis</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="Y">cytology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018859" MajorTopicYN="N">Hair Follicle</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="Y">cytology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015603" MajorTopicYN="N">Keratinocytes</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008962" MajorTopicYN="N">Models, Theoretical</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012867" MajorTopicYN="N">Skin</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D062211" MajorTopicYN="N">Spatio-Temporal Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013234" MajorTopicYN="N">Stem Cells</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Brainbow model</Keyword><Keyword MajorTopicYN="N">epidermal stem cells</Keyword><Keyword MajorTopicYN="N">hair follicle cycle</Keyword><Keyword MajorTopicYN="N">homeostasis</Keyword><Keyword MajorTopicYN="N">multicolour tracing model</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>01</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>09</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>09</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="pmc-release"><Year>2017</Year><Month>12</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>11</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>7</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>11</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27797819</ArticleId><ArticleId IdType="pii">embj.201693806</ArticleId><ArticleId IdType="doi">10.15252/embj.201693806</ArticleId><ArticleId IdType="pmc">PMC5167353</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="Australie"><noRegion><name sortKey="Roy, Edwige" sort="Roy, Edwige" uniqKey="Roy E" first="Edwige" last="Roy">Edwige Roy</name></noRegion><name sortKey="Cerone, Luca" sort="Cerone, Luca" uniqKey="Cerone L" first="Luca" last="Cerone">Luca Cerone</name><name sortKey="Hodgson, Samantha" sort="Hodgson, Samantha" uniqKey="Hodgson S" first="Samantha" last="Hodgson">Samantha Hodgson</name><name sortKey="Khosrotehrani, Kiarash" sort="Khosrotehrani, Kiarash" uniqKey="Khosrotehrani K" first="Kiarash" last="Khosrotehrani">Kiarash Khosrotehrani</name><name sortKey="Neufeld, Zoltan" sort="Neufeld, Zoltan" uniqKey="Neufeld Z" first="Zoltan" last="Neufeld">Zoltan Neufeld</name><name sortKey="Wong, Ho Yi" sort="Wong, Ho Yi" uniqKey="Wong H" first="Ho Yi" last="Wong">Ho Yi Wong</name></country><country name="France"><region name="Île-de-France"><name sortKey="Livet, Jean" sort="Livet, Jean" uniqKey="Livet J" first="Jean" last="Livet">Jean Livet</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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