CD4(+) T Follicular Helper and IgA(+) B Cell Numbers in Gut Biopsies from HIV-Infected Subjects on Antiretroviral Therapy Are Similar to HIV-Uninfected Individuals.
Identifieur interne : 002240 ( PubMed/Checkpoint ); précédent : 002239; suivant : 002241CD4(+) T Follicular Helper and IgA(+) B Cell Numbers in Gut Biopsies from HIV-Infected Subjects on Antiretroviral Therapy Are Similar to HIV-Uninfected Individuals.
Auteurs : John Zaunders [Australie] ; Mark Danta [Australie] ; Michelle Bailey [Australie] ; Gerald Mak [Australie] ; Katherine Marks [Australie] ; Nabila Seddiki [France] ; Yin Xu [Australie] ; David J. Templeton [Australie] ; David A. Cooper [Australie] ; Mark A. Boyd [Australie] ; Anthony D. Kelleher [Australie] ; Kersten K. Koelsch [Australie]Source :
- Frontiers in immunology [ 1664-3224 ] ; 2016.
Abstract
Disruption of gastrointestinal tract epithelial and immune barriers contribute to microbial translocation, systemic inflammation, and progression of HIV-1 infection. Antiretroviral therapy (ART) may lead to reconstitution of CD4(+) T cells in gut-associated lymphoid tissue (GALT), but its impact on humoral immunity within GALT is unclear. Therefore, we studied CD4(+) subsets, including T follicular helper cells (Tfh), as well as resident B cells that have switched to IgA production, in gut biopsies, from HIV(+) subjects on suppressive ART compared to HIV-negative controls (HNC).
DOI: 10.3389/fimmu.2016.00438
PubMed: 27822211
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:27822211Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">CD4(+) T Follicular Helper and IgA(+) B Cell Numbers in Gut Biopsies from HIV-Infected Subjects on Antiretroviral Therapy Are Similar to HIV-Uninfected Individuals.</title><author><name sortKey="Zaunders, John" sort="Zaunders, John" uniqKey="Zaunders J" first="John" last="Zaunders">John Zaunders</name><affiliation wicri:level="1"><nlm:affiliation>St Vincent's Centre for Applied Medical Research, St Vincent's Hospital, Sydney, NSW, Australia; The Kirby Institute, The University of New South Wales, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>St Vincent's Centre for Applied Medical Research, St Vincent's Hospital, Sydney, NSW, Australia; The Kirby Institute, The University of New South Wales, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Danta, Mark" sort="Danta, Mark" uniqKey="Danta M" first="Mark" last="Danta">Mark Danta</name><affiliation wicri:level="1"><nlm:affiliation>St Vincent's Hospital, Clinical School , Sydney, NSW , Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>St Vincent's Hospital, Clinical School , Sydney, NSW </wicri:regionArea><wicri:noRegion>NSW </wicri:noRegion></affiliation></author><author><name sortKey="Bailey, Michelle" sort="Bailey, Michelle" uniqKey="Bailey M" first="Michelle" last="Bailey">Michelle Bailey</name><affiliation wicri:level="1"><nlm:affiliation>The Kirby Institute, The University of New South Wales , Sydney, NSW , Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Kirby Institute, The University of New South Wales , Sydney, NSW </wicri:regionArea><wicri:noRegion>NSW </wicri:noRegion></affiliation></author><author><name sortKey="Mak, Gerald" sort="Mak, Gerald" uniqKey="Mak G" first="Gerald" last="Mak">Gerald Mak</name><affiliation wicri:level="1"><nlm:affiliation>St Vincent's Hospital, Clinical School , Sydney, NSW , Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>St Vincent's Hospital, Clinical School , Sydney, NSW </wicri:regionArea><wicri:noRegion>NSW </wicri:noRegion></affiliation></author><author><name sortKey="Marks, Katherine" sort="Marks, Katherine" uniqKey="Marks K" first="Katherine" last="Marks">Katherine Marks</name><affiliation wicri:level="1"><nlm:affiliation>St Vincent's Centre for Applied Medical Research, St Vincent's Hospital , Sydney, NSW , Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>St Vincent's Centre for Applied Medical Research, St Vincent's Hospital , Sydney, NSW </wicri:regionArea><wicri:noRegion>NSW </wicri:noRegion></affiliation></author><author><name sortKey="Seddiki, Nabila" sort="Seddiki, Nabila" uniqKey="Seddiki N" first="Nabila" last="Seddiki">Nabila Seddiki</name><affiliation wicri:level="3"><nlm:affiliation>Equipe 16, INSERM U955, Créteil, France; Faculté de médecine, Université Paris Est, Créteil, France; Vaccine Research Institute (VRI), Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Equipe 16, INSERM U955, Créteil, France; Faculté de médecine, Université Paris Est, Créteil, France; Vaccine Research Institute (VRI), Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Xu, Yin" sort="Xu, Yin" uniqKey="Xu Y" first="Yin" last="Xu">Yin Xu</name><affiliation wicri:level="1"><nlm:affiliation>The Kirby Institute, The University of New South Wales , Sydney, NSW , Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Kirby Institute, The University of New South Wales , Sydney, NSW </wicri:regionArea><wicri:noRegion>NSW </wicri:noRegion></affiliation></author><author><name sortKey="Templeton, David J" sort="Templeton, David J" uniqKey="Templeton D" first="David J" last="Templeton">David J. Templeton</name><affiliation wicri:level="1"><nlm:affiliation>The Kirby Institute, The University of New South Wales, Sydney, NSW, Australia; RPA Sexual Health, Royal Prince Alfred Hospital, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Kirby Institute, The University of New South Wales, Sydney, NSW, Australia; RPA Sexual Health, Royal Prince Alfred Hospital, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Cooper, David A" sort="Cooper, David A" uniqKey="Cooper D" first="David A" last="Cooper">David A. Cooper</name><affiliation wicri:level="1"><nlm:affiliation>St Vincent's Centre for Applied Medical Research, St Vincent's Hospital, Sydney, NSW, Australia; The Kirby Institute, The University of New South Wales, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>St Vincent's Centre for Applied Medical Research, St Vincent's Hospital, Sydney, NSW, Australia; The Kirby Institute, The University of New South Wales, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Boyd, Mark A" sort="Boyd, Mark A" uniqKey="Boyd M" first="Mark A" last="Boyd">Mark A. Boyd</name><affiliation wicri:level="1"><nlm:affiliation>The Kirby Institute, The University of New South Wales , Sydney, NSW , Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Kirby Institute, The University of New South Wales , Sydney, NSW </wicri:regionArea><wicri:noRegion>NSW </wicri:noRegion></affiliation></author><author><name sortKey="Kelleher, Anthony D" sort="Kelleher, Anthony D" uniqKey="Kelleher A" first="Anthony D" last="Kelleher">Anthony D. Kelleher</name><affiliation wicri:level="1"><nlm:affiliation>St Vincent's Centre for Applied Medical Research, St Vincent's Hospital, Sydney, NSW, Australia; The Kirby Institute, The University of New South Wales, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>St Vincent's Centre for Applied Medical Research, St Vincent's Hospital, Sydney, NSW, Australia; The Kirby Institute, The University of New South Wales, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Koelsch, Kersten K" sort="Koelsch, Kersten K" uniqKey="Koelsch K" first="Kersten K" last="Koelsch">Kersten K. Koelsch</name><affiliation wicri:level="1"><nlm:affiliation>The Kirby Institute, The University of New South Wales , Sydney, NSW , Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Kirby Institute, The University of New South Wales , Sydney, NSW </wicri:regionArea><wicri:noRegion>NSW </wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27822211</idno><idno type="pmid">27822211</idno><idno type="doi">10.3389/fimmu.2016.00438</idno><idno type="wicri:Area/PubMed/Corpus">001707</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001707</idno><idno type="wicri:Area/PubMed/Curation">001684</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001684</idno><idno type="wicri:Area/PubMed/Checkpoint">001684</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001684</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">CD4(+) T Follicular Helper and IgA(+) B Cell Numbers in Gut Biopsies from HIV-Infected Subjects on Antiretroviral Therapy Are Similar to HIV-Uninfected Individuals.</title><author><name sortKey="Zaunders, John" sort="Zaunders, John" uniqKey="Zaunders J" first="John" last="Zaunders">John Zaunders</name><affiliation wicri:level="1"><nlm:affiliation>St Vincent's Centre for Applied Medical Research, St Vincent's Hospital, Sydney, NSW, Australia; The Kirby Institute, The University of New South Wales, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>St Vincent's Centre for Applied Medical Research, St Vincent's Hospital, Sydney, NSW, Australia; The Kirby Institute, The University of New South Wales, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Danta, Mark" sort="Danta, Mark" uniqKey="Danta M" first="Mark" last="Danta">Mark Danta</name><affiliation wicri:level="1"><nlm:affiliation>St Vincent's Hospital, Clinical School , Sydney, NSW , Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>St Vincent's Hospital, Clinical School , Sydney, NSW </wicri:regionArea><wicri:noRegion>NSW </wicri:noRegion></affiliation></author><author><name sortKey="Bailey, Michelle" sort="Bailey, Michelle" uniqKey="Bailey M" first="Michelle" last="Bailey">Michelle Bailey</name><affiliation wicri:level="1"><nlm:affiliation>The Kirby Institute, The University of New South Wales , Sydney, NSW , Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Kirby Institute, The University of New South Wales , Sydney, NSW </wicri:regionArea><wicri:noRegion>NSW </wicri:noRegion></affiliation></author><author><name sortKey="Mak, Gerald" sort="Mak, Gerald" uniqKey="Mak G" first="Gerald" last="Mak">Gerald Mak</name><affiliation wicri:level="1"><nlm:affiliation>St Vincent's Hospital, Clinical School , Sydney, NSW , Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>St Vincent's Hospital, Clinical School , Sydney, NSW </wicri:regionArea><wicri:noRegion>NSW </wicri:noRegion></affiliation></author><author><name sortKey="Marks, Katherine" sort="Marks, Katherine" uniqKey="Marks K" first="Katherine" last="Marks">Katherine Marks</name><affiliation wicri:level="1"><nlm:affiliation>St Vincent's Centre for Applied Medical Research, St Vincent's Hospital , Sydney, NSW , Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>St Vincent's Centre for Applied Medical Research, St Vincent's Hospital , Sydney, NSW </wicri:regionArea><wicri:noRegion>NSW </wicri:noRegion></affiliation></author><author><name sortKey="Seddiki, Nabila" sort="Seddiki, Nabila" uniqKey="Seddiki N" first="Nabila" last="Seddiki">Nabila Seddiki</name><affiliation wicri:level="3"><nlm:affiliation>Equipe 16, INSERM U955, Créteil, France; Faculté de médecine, Université Paris Est, Créteil, France; Vaccine Research Institute (VRI), Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Equipe 16, INSERM U955, Créteil, France; Faculté de médecine, Université Paris Est, Créteil, France; Vaccine Research Institute (VRI), Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Xu, Yin" sort="Xu, Yin" uniqKey="Xu Y" first="Yin" last="Xu">Yin Xu</name><affiliation wicri:level="1"><nlm:affiliation>The Kirby Institute, The University of New South Wales , Sydney, NSW , Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Kirby Institute, The University of New South Wales , Sydney, NSW </wicri:regionArea><wicri:noRegion>NSW </wicri:noRegion></affiliation></author><author><name sortKey="Templeton, David J" sort="Templeton, David J" uniqKey="Templeton D" first="David J" last="Templeton">David J. Templeton</name><affiliation wicri:level="1"><nlm:affiliation>The Kirby Institute, The University of New South Wales, Sydney, NSW, Australia; RPA Sexual Health, Royal Prince Alfred Hospital, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Kirby Institute, The University of New South Wales, Sydney, NSW, Australia; RPA Sexual Health, Royal Prince Alfred Hospital, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Cooper, David A" sort="Cooper, David A" uniqKey="Cooper D" first="David A" last="Cooper">David A. Cooper</name><affiliation wicri:level="1"><nlm:affiliation>St Vincent's Centre for Applied Medical Research, St Vincent's Hospital, Sydney, NSW, Australia; The Kirby Institute, The University of New South Wales, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>St Vincent's Centre for Applied Medical Research, St Vincent's Hospital, Sydney, NSW, Australia; The Kirby Institute, The University of New South Wales, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Boyd, Mark A" sort="Boyd, Mark A" uniqKey="Boyd M" first="Mark A" last="Boyd">Mark A. Boyd</name><affiliation wicri:level="1"><nlm:affiliation>The Kirby Institute, The University of New South Wales , Sydney, NSW , Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Kirby Institute, The University of New South Wales , Sydney, NSW </wicri:regionArea><wicri:noRegion>NSW </wicri:noRegion></affiliation></author><author><name sortKey="Kelleher, Anthony D" sort="Kelleher, Anthony D" uniqKey="Kelleher A" first="Anthony D" last="Kelleher">Anthony D. Kelleher</name><affiliation wicri:level="1"><nlm:affiliation>St Vincent's Centre for Applied Medical Research, St Vincent's Hospital, Sydney, NSW, Australia; The Kirby Institute, The University of New South Wales, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>St Vincent's Centre for Applied Medical Research, St Vincent's Hospital, Sydney, NSW, Australia; The Kirby Institute, The University of New South Wales, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Koelsch, Kersten K" sort="Koelsch, Kersten K" uniqKey="Koelsch K" first="Kersten K" last="Koelsch">Kersten K. Koelsch</name><affiliation wicri:level="1"><nlm:affiliation>The Kirby Institute, The University of New South Wales , Sydney, NSW , Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Kirby Institute, The University of New South Wales , Sydney, NSW </wicri:regionArea><wicri:noRegion>NSW </wicri:noRegion></affiliation></author></analytic><series><title level="j">Frontiers in immunology</title><idno type="ISSN">1664-3224</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Disruption of gastrointestinal tract epithelial and immune barriers contribute to microbial translocation, systemic inflammation, and progression of HIV-1 infection. Antiretroviral therapy (ART) may lead to reconstitution of CD4(+) T cells in gut-associated lymphoid tissue (GALT), but its impact on humoral immunity within GALT is unclear. Therefore, we studied CD4(+) subsets, including T follicular helper cells (Tfh), as well as resident B cells that have switched to IgA production, in gut biopsies, from HIV(+) subjects on suppressive ART compared to HIV-negative controls (HNC).</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">27822211</PMID><DateCreated><Year>2016</Year><Month>11</Month><Day>08</Day></DateCreated><DateRevised><Year>2017</Year><Month>08</Month><Day>16</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">1664-3224</ISSN><JournalIssue CitedMedium="Print"><Volume>7</Volume><PubDate><Year>2016</Year></PubDate></JournalIssue><Title>Frontiers in immunology</Title><ISOAbbreviation>Front Immunol</ISOAbbreviation></Journal><ArticleTitle>CD4(+) T Follicular Helper and IgA(+) B Cell Numbers in Gut Biopsies from HIV-Infected Subjects on Antiretroviral Therapy Are Similar to HIV-Uninfected Individuals.</ArticleTitle><Pagination><MedlinePgn>438</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Disruption of gastrointestinal tract epithelial and immune barriers contribute to microbial translocation, systemic inflammation, and progression of HIV-1 infection. Antiretroviral therapy (ART) may lead to reconstitution of CD4(+) T cells in gut-associated lymphoid tissue (GALT), but its impact on humoral immunity within GALT is unclear. Therefore, we studied CD4(+) subsets, including T follicular helper cells (Tfh), as well as resident B cells that have switched to IgA production, in gut biopsies, from HIV(+) subjects on suppressive ART compared to HIV-negative controls (HNC).</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Twenty-three HIV(+) subjects on ART and 22 HNC undergoing colonoscopy were recruited to the study. Single-cell suspensions were prepared from biopsies from left colon (LC), right colon (RC), and terminal ileum (TI). T and B lymphocyte subsets, as well as EpCAM(+) epithelial cells, were accurately enumerated by flow cytometry, using counting beads.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">No significant differences in the number of recovered epithelial cells were observed between the two subject groups. However, the median TI CD4(+) T cell count/10(6) epithelial cells was 2.4-fold lower in HIV(+) subjects versus HNC (19,679 versus 47,504 cells; p = 0.02). Similarly, median LC CD4(+) T cell counts were reduced in HIV(+) subjects (8,358 versus 18,577; p = 0.03) but were not reduced in RC. Importantly, we found no significant differences in Tfh or IgA(+) B cell counts at either site between HIV(+) subjects and HNC. Further analysis showed no difference in CD4(+), Tfh, or IgA(+) B cell counts between subjects who commenced ART in primary compared to chronic HIV-1 infection. Despite the decrease in total CD4 T cells, we could not identify a selective decrease of other key subsets of CD4(+) T cells, including CCR5(+) cells, CD127(+) long-term memory cells, CD103(+) tissue-resident cells, or CD161(+) cells (surrogate marker for Th17), but there was a slight increase in the proportion of T regulatory cells.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">While there were lower absolute CD4(+) counts in the TI and LC in HIV(+) subjects on ART, they were not associated with significantly reduced Tfh cell counts or IgA(+) B cells, suggesting that this important vanguard of adaptive immune defense against luminal microbial products is normalized following ART.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zaunders</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>St Vincent's Centre for Applied Medical Research, St Vincent's Hospital, Sydney, NSW, Australia; The Kirby Institute, The University of New South Wales, Sydney, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Danta</LastName><ForeName>Mark</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>St Vincent's Hospital, Clinical School , Sydney, NSW , Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bailey</LastName><ForeName>Michelle</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>The Kirby Institute, The University of New South Wales , Sydney, NSW , Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mak</LastName><ForeName>Gerald</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>St Vincent's Hospital, Clinical School , Sydney, NSW , Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marks</LastName><ForeName>Katherine</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>St Vincent's Centre for Applied Medical Research, St Vincent's Hospital , Sydney, NSW , Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seddiki</LastName><ForeName>Nabila</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Equipe 16, INSERM U955, Créteil, France; Faculté de médecine, Université Paris Est, Créteil, France; Vaccine Research Institute (VRI), Créteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Yin</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>The Kirby Institute, The University of New South Wales , Sydney, NSW , Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Templeton</LastName><ForeName>David J</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>The Kirby Institute, The University of New South Wales, Sydney, NSW, Australia; RPA Sexual Health, Royal Prince Alfred Hospital, Sydney, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cooper</LastName><ForeName>David A</ForeName><Initials>DA</Initials><AffiliationInfo><Affiliation>St Vincent's Centre for Applied Medical Research, St Vincent's Hospital, Sydney, NSW, Australia; The Kirby Institute, The University of New South Wales, Sydney, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boyd</LastName><ForeName>Mark A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>The Kirby Institute, The University of New South Wales , Sydney, NSW , Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kelleher</LastName><ForeName>Anthony D</ForeName><Initials>AD</Initials><AffiliationInfo><Affiliation>St Vincent's Centre for Applied Medical Research, St Vincent's Hospital, Sydney, NSW, Australia; The Kirby Institute, The University of New South Wales, Sydney, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Koelsch</LastName><ForeName>Kersten K</ForeName><Initials>KK</Initials><AffiliationInfo><Affiliation>The Kirby Institute, The University of New South Wales , Sydney, NSW , Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>10</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Front Immunol</MedlineTA><NlmUniqueID>101560960</NlmUniqueID><ISSNLinking>1664-3224</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Mucosal Immunol. 2011 Nov;4(6):603-11</RefSource><PMID Version="1">21975936</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cytometry A. 2016 Jan;89(1):44-58</RefSource><PMID Version="1">26097104</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Virol. 2013 Apr;87(7):3760-73</RefSource><PMID Version="1">23325697</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Virol. 2006 Oct;80(20):10162-72</RefSource><PMID Version="1">17005693</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>AIDS. 2000 Aug 18;14(12):1761-5</RefSource><PMID Version="1">10985313</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Exp Med. 2013 Jan 14;210(1):143-56</RefSource><PMID Version="1">23254284</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Exp Med. 2004 Sep 20;200(6):749-59</RefSource><PMID Version="1">15365096</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Infect Dis. 2008 Mar 1;197(5):714-20</RefSource><PMID Version="1">18260759</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Exp Med. 2004 Sep 20;200(6):761-70</RefSource><PMID Version="1">15365095</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>AIDS. 2010 Oct 23;24(16):2451-60</RefSource><PMID Version="1">20827162</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Immunol Immunopathol. 1997 Mar;82(3):230-42</RefSource><PMID Version="1">9073546</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mucosal Immunol. 2008 Nov;1(6):475-88</RefSource><PMID Version="1">19079215</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>AIDS. 2011 Nov 13;25(17):2069-78</RefSource><PMID Version="1">21860347</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2015 Mar 26;10(3):e0121290</RefSource><PMID Version="1">25811360</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>AIDS. 2015 May 15;29(8):911-9</RefSource><PMID Version="1">25730509</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2012 Sep 15;189(6):2702-6</RefSource><PMID Version="1">22896631</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mucosal Immunol. 2015 Jan;8(1):127-40</RefSource><PMID Version="1">24985081</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Virol. 1998 Aug;72(8):6646-56</RefSource><PMID Version="1">9658111</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Curr Opin HIV AIDS. 2008 Jan;3(1):22-7</RefSource><PMID Version="1">19372940</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2005 Mar 15;174(6):3143-7</RefSource><PMID Version="1">15749840</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Virol. 2003 Nov;77(21):11708-17</RefSource><PMID Version="1">14557656</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2008 Apr 15;180(8):5582-92</RefSource><PMID Version="1">18390743</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Blood. 2006 Nov 1;108(9):3072-8</RefSource><PMID Version="1">16728694</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Immunol. 2006 Mar;7(3):235-9</RefSource><PMID Version="1">16482171</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>AIDS. 2015 Jan 2;29(1):43-51</RefSource><PMID Version="1">25387317</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mucosal Immunol. 2012 Nov;5(6):596-604</RefSource><PMID Version="1">22929559</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2012 Apr 1;188(7):3247-56</RefSource><PMID Version="1">22387550</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Immunity. 2004 May;20(5):551-62</RefSource><PMID Version="1">15142524</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Virol. 2007 Jan;81(2):599-612</RefSource><PMID Version="1">17065209</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>AIDS Res Hum Retroviruses. 2013 Oct;29(10):1330-9</RefSource><PMID Version="1">23971972</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Infect Dis. 2006 Feb 15;193(4):505-14</RefSource><PMID Version="1">16425129</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Top HIV Med. 2007 Aug-Sep;15(4):114-7</RefSource><PMID Version="1">17720995</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Pathog. 2014 Dec 11;10(12):e1004543</RefSource><PMID Version="1">25503054</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Virol. 2006 Aug;80(16):8236-47</RefSource><PMID Version="1">16873279</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Gut. 2004 Apr;53(4):487-93</RefSource><PMID Version="1">15016741</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Virol. 2006 Oct;80(20):10151-61</RefSource><PMID Version="1">17005692</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Annu Rev Immunol. 2012;30:149-73</RefSource><PMID Version="1">22224779</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Infect Dis. 2000 Mar;181(3):927-32</RefSource><PMID Version="1">10720514</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Invest. 2012 Sep;122(9):3281-94</RefSource><PMID Version="1">22922258</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Virol. 2001 Sep;75(18):8390-9</RefSource><PMID Version="1">11507184</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Annu Rev Immunol. 2010;28:243-73</RefSource><PMID Version="1">20192805</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Pathol. 2007 Aug;171(2):386-95</RefSource><PMID Version="1">17600130</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Blood. 2005 Sep 1;106(5):1660-7</RefSource><PMID Version="1">15905189</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2015 Oct 26;10(10):e0140978</RefSource><PMID Version="1">26501424</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Blood. 2011 Nov 24;118(22):5803-12</RefSource><PMID Version="1">21960586</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol Methods. 2000 Mar 6;236(1-2):27-35</RefSource><PMID Version="1">10699577</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Immunol. 2012 Aug;144(2):159-71</RefSource><PMID Version="1">22772031</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mucosal Immunol. 2011 Jan;4(1):31-42</RefSource><PMID Version="1">20962772</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Med. 2006 Dec;12(12):1365-71</RefSource><PMID Version="1">17115046</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2012 May 1;109(18):7037-42</RefSource><PMID Version="1">22509047</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Exp Med. 2006 Jul 10;203(7):1693-700</RefSource><PMID Version="1">16818676</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Med. 2009 Jul 7;6(7):e1000107</RefSource><PMID Version="1">19582166</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Annu Rev Med. 2009;60:471-84</RefSource><PMID Version="1">18947296</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Med. 2001 Jan;7(1):73-9</RefSource><PMID Version="1">11135619</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Exp Med. 2009 Mar 16;206(3):525-34</RefSource><PMID Version="1">19273624</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Infect Dis. 2001 Mar 1;183(5):736-43</RefSource><PMID Version="1">11181150</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mucosal Immunol. 2011 Jan;4(1):15-21</RefSource><PMID Version="1">20944557</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Med. 2006 Dec;3(12):e484</RefSource><PMID Version="1">17147468</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Immunol. 2013 Apr;14(4):372-9</RefSource><PMID Version="1">23475182</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Curr Opin Immunol. 2015 Oct;36:22-30</RefSource><PMID Version="1">26151777</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2010 Nov 1;185(9):5169-79</RefSource><PMID Version="1">20889546</PMID></CommentsCorrections></CommentsCorrectionsList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">CD4+ T lymphocytes</Keyword><Keyword MajorTopicYN="N">HIV</Keyword><Keyword MajorTopicYN="N">IgA B cells</Keyword><Keyword MajorTopicYN="N">T follicular helper cells</Keyword><Keyword MajorTopicYN="N">germinal centers</Keyword><Keyword MajorTopicYN="N">gut-associated lymphoid tissue</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>05</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>10</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>11</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>11</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>11</Month><Day>9</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27822211</ArticleId><ArticleId IdType="doi">10.3389/fimmu.2016.00438</ArticleId><ArticleId IdType="pmc">PMC5075890</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Créteil</li></settlement></list><tree><country name="Australie"><noRegion><name sortKey="Zaunders, John" sort="Zaunders, John" uniqKey="Zaunders J" first="John" last="Zaunders">John Zaunders</name></noRegion><name sortKey="Bailey, Michelle" sort="Bailey, Michelle" uniqKey="Bailey M" first="Michelle" last="Bailey">Michelle Bailey</name><name sortKey="Boyd, Mark A" sort="Boyd, Mark A" uniqKey="Boyd M" first="Mark A" last="Boyd">Mark A. Boyd</name><name sortKey="Cooper, David A" sort="Cooper, David A" uniqKey="Cooper D" first="David A" last="Cooper">David A. Cooper</name><name sortKey="Danta, Mark" sort="Danta, Mark" uniqKey="Danta M" first="Mark" last="Danta">Mark Danta</name><name sortKey="Kelleher, Anthony D" sort="Kelleher, Anthony D" uniqKey="Kelleher A" first="Anthony D" last="Kelleher">Anthony D. Kelleher</name><name sortKey="Koelsch, Kersten K" sort="Koelsch, Kersten K" uniqKey="Koelsch K" first="Kersten K" last="Koelsch">Kersten K. Koelsch</name><name sortKey="Mak, Gerald" sort="Mak, Gerald" uniqKey="Mak G" first="Gerald" last="Mak">Gerald Mak</name><name sortKey="Marks, Katherine" sort="Marks, Katherine" uniqKey="Marks K" first="Katherine" last="Marks">Katherine Marks</name><name sortKey="Templeton, David J" sort="Templeton, David J" uniqKey="Templeton D" first="David J" last="Templeton">David J. Templeton</name><name sortKey="Xu, Yin" sort="Xu, Yin" uniqKey="Xu Y" first="Yin" last="Xu">Yin Xu</name></country><country name="France"><region name="Île-de-France"><name sortKey="Seddiki, Nabila" sort="Seddiki, Nabila" uniqKey="Seddiki N" first="Nabila" last="Seddiki">Nabila Seddiki</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002240 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 002240 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= PubMed
|étape= Checkpoint
|type= RBID
|clé= pubmed:27822211
|texte= CD4(+) T Follicular Helper and IgA(+) B Cell Numbers in Gut Biopsies from HIV-Infected Subjects on Antiretroviral Therapy Are Similar to HIV-Uninfected Individuals.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:27822211" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |