Correlation of KIT and PDGFRA mutational status with clinical benefit in patients with gastrointestinal stromal tumor treated with sunitinib in a worldwide treatment-use trial.
Identifieur interne : 002120 ( PubMed/Checkpoint ); précédent : 002119; suivant : 002121Correlation of KIT and PDGFRA mutational status with clinical benefit in patients with gastrointestinal stromal tumor treated with sunitinib in a worldwide treatment-use trial.
Auteurs : Peter Reichardt [Allemagne] ; George D. Demetri [États-Unis] ; Hans Gelderblom [Pays-Bas] ; Piotr Rutkowski [Pologne] ; Seock-Ah Im [Corée du Sud] ; Sudeep Gupta [Inde] ; Yoon-Koo Kang [Corée du Sud] ; Patrick Schöffski [Belgique] ; Jochen Schuette [Allemagne] ; Denis Soulières [Canada] ; Jean-Yves Blay [France] ; David Goldstein [Australie] ; Kolette Fly [États-Unis] ; Xin Huang [États-Unis] ; Massimo Corsaro [Italie] ; Maria Jose Lechuga [Italie] ; Jean-Francois Martini [États-Unis] ; Michael C. Heinrich [États-Unis]Source :
- BMC cancer [ 1471-2407 ] ; 2016.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Femelle, Génotype, Humains, Indoles (administration et posologie), Indoles (effets indésirables), Inhibiteurs de protéines kinases (administration et posologie), Mutation, Mâle, Pronostic, Protéines proto-oncogènes c-kit (génétique), Pyrroles (administration et posologie), Pyrroles (effets indésirables), Récepteur au PDGF alpha (génétique), Résistance aux médicaments antinéoplasiques (génétique), Sujet âgé, Sujet âgé de 80 ans ou plus, Survie sans rechute, Tumeurs stromales gastro-intestinales (anatomopathologie), Tumeurs stromales gastro-intestinales (génétique), Tumeurs stromales gastro-intestinales (traitement médicamenteux).
- MESH :
- administration et posologie : Indoles, Inhibiteurs de protéines kinases, Pyrroles.
- anatomopathologie : Tumeurs stromales gastro-intestinales.
- effets indésirables : Indoles, Pyrroles.
- génétique : Protéines proto-oncogènes c-kit, Récepteur au PDGF alpha, Résistance aux médicaments antinéoplasiques, Tumeurs stromales gastro-intestinales.
- traitement médicamenteux : Tumeurs stromales gastro-intestinales.
- Adolescent, Adulte, Adulte d'âge moyen, Femelle, Génotype, Humains, Mutation, Mâle, Pronostic, Sujet âgé, Sujet âgé de 80 ans ou plus, Survie sans rechute.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Disease-Free Survival, Drug Resistance, Neoplasm (genetics), Female, Gastrointestinal Stromal Tumors (drug therapy), Gastrointestinal Stromal Tumors (genetics), Gastrointestinal Stromal Tumors (pathology), Genotype, Humans, Indoles (administration & dosage), Indoles (adverse effects), Male, Middle Aged, Mutation, Prognosis, Protein Kinase Inhibitors (administration & dosage), Proto-Oncogene Proteins c-kit (genetics), Pyrroles (administration & dosage), Pyrroles (adverse effects), Receptor, Platelet-Derived Growth Factor alpha (genetics).
- MESH :
- chemical , administration & dosage : Indoles, Protein Kinase Inhibitors, Pyrroles.
- chemical , adverse effects : Indoles, Pyrroles.
- drug therapy : Gastrointestinal Stromal Tumors.
- genetics : Drug Resistance, Neoplasm, Gastrointestinal Stromal Tumors, Proto-Oncogene Proteins c-kit, Receptor, Platelet-Derived Growth Factor alpha.
- pathology : Gastrointestinal Stromal Tumors.
- Adolescent, Adult, Aged, Aged, 80 and over, Disease-Free Survival, Female, Genotype, Humans, Male, Middle Aged, Mutation, Prognosis.
Abstract
Several small studies indicated that the genotype of KIT or platelet-derived growth factor receptor-α (PDGFRA) contributes in part to the level of clinical effectiveness of sunitinib in gastrointestinal stromal tumor (GIST) patients. This study aimed to correlate KIT and PDGFRA mutational status with clinical outcome metrics (progression-free survival [PFS], overall survival [OS], objective response rate [ORR]) in a larger international patient population.
DOI: 10.1186/s12885-016-2051-5
PubMed: 26772734
Affiliations:
- Allemagne, Australie, Belgique, Canada, Corée du Sud, France, Inde, Italie, Pays-Bas, Pologne, États-Unis
- Auvergne-Rhône-Alpes, Berlin, Californie, Connecticut, District de Düsseldorf, Hollande-Méridionale, Lombardie, Massachusetts, Nouvelle-Galles du Sud, Oregon, Rhénanie-du-Nord-Westphalie, Rhône-Alpes, Région capitale de Séoul
- Berlin, Düsseldorf, Leyde, Lyon, Milan, Sydney, Séoul
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:26772734Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Correlation of KIT and PDGFRA mutational status with clinical benefit in patients with gastrointestinal stromal tumor treated with sunitinib in a worldwide treatment-use trial.</title>
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<author><name sortKey="Demetri, George D" sort="Demetri, George D" uniqKey="Demetri G" first="George D" last="Demetri">George D. Demetri</name>
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<author><name sortKey="Gelderblom, Hans" sort="Gelderblom, Hans" uniqKey="Gelderblom H" first="Hans" last="Gelderblom">Hans Gelderblom</name>
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<author><name sortKey="Im, Seock Ah" sort="Im, Seock Ah" uniqKey="Im S" first="Seock-Ah" last="Im">Seock-Ah Im</name>
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<author><name sortKey="Gupta, Sudeep" sort="Gupta, Sudeep" uniqKey="Gupta S" first="Sudeep" last="Gupta">Sudeep Gupta</name>
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<author><name sortKey="Schoffski, Patrick" sort="Schoffski, Patrick" uniqKey="Schoffski P" first="Patrick" last="Schöffski">Patrick Schöffski</name>
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<author><name sortKey="Schuette, Jochen" sort="Schuette, Jochen" uniqKey="Schuette J" first="Jochen" last="Schuette">Jochen Schuette</name>
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<author><name sortKey="Blay, Jean Yves" sort="Blay, Jean Yves" uniqKey="Blay J" first="Jean-Yves" last="Blay">Jean-Yves Blay</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, Université Claude Bernard, Lyon, France. jean-yves.blay@lyon.unicancer.fr.</nlm:affiliation>
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<author><name sortKey="Goldstein, David" sort="Goldstein, David" uniqKey="Goldstein D" first="David" last="Goldstein">David Goldstein</name>
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<author><name sortKey="Fly, Kolette" sort="Fly, Kolette" uniqKey="Fly K" first="Kolette" last="Fly">Kolette Fly</name>
<affiliation wicri:level="2"><nlm:affiliation>Pfizer Oncology, Groton, CT, USA. kolette.d.fly@pfizer.com.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Pfizer Oncology, Groton, CT</wicri:regionArea>
<placeName><region type="state">Connecticut</region>
</placeName>
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<author><name sortKey="Huang, Xin" sort="Huang, Xin" uniqKey="Huang X" first="Xin" last="Huang">Xin Huang</name>
<affiliation wicri:level="2"><nlm:affiliation>Pfizer Oncology, La Jolla, CA, USA. xin.huang@pfizer.com.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Corsaro, Massimo" sort="Corsaro, Massimo" uniqKey="Corsaro M" first="Massimo" last="Corsaro">Massimo Corsaro</name>
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<country xml:lang="fr">Italie</country>
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<placeName><settlement type="city">Milan</settlement>
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</author>
<author><name sortKey="Lechuga, Maria Jose" sort="Lechuga, Maria Jose" uniqKey="Lechuga M" first="Maria Jose" last="Lechuga">Maria Jose Lechuga</name>
<affiliation wicri:level="3"><nlm:affiliation>Pfizer Oncology, Milan, Italy. mariajose.lechuga@pfizer.com.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
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<author><name sortKey="Martini, Jean Francois" sort="Martini, Jean Francois" uniqKey="Martini J" first="Jean-Francois" last="Martini">Jean-Francois Martini</name>
<affiliation wicri:level="2"><nlm:affiliation>Pfizer Oncology, La Jolla, CA, USA. jean-francois.martini@pfizer.com.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Heinrich, Michael C" sort="Heinrich, Michael C" uniqKey="Heinrich M" first="Michael C" last="Heinrich">Michael C. Heinrich</name>
<affiliation wicri:level="2"><nlm:affiliation>VA Portland Health Care System and Oregon Health & Science University, Portland, OR, USA. heinrich@ohsu.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
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<placeName><region type="state">Oregon</region>
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<series><title level="j">BMC cancer</title>
<idno type="eISSN">1471-2407</idno>
<imprint><date when="2016" type="published">2016</date>
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<term>Adult</term>
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<term>Aged, 80 and over</term>
<term>Disease-Free Survival</term>
<term>Drug Resistance, Neoplasm (genetics)</term>
<term>Female</term>
<term>Gastrointestinal Stromal Tumors (drug therapy)</term>
<term>Gastrointestinal Stromal Tumors (genetics)</term>
<term>Gastrointestinal Stromal Tumors (pathology)</term>
<term>Genotype</term>
<term>Humans</term>
<term>Indoles (administration & dosage)</term>
<term>Indoles (adverse effects)</term>
<term>Male</term>
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<term>Mutation</term>
<term>Prognosis</term>
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<term>Pyrroles (administration & dosage)</term>
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<term>Receptor, Platelet-Derived Growth Factor alpha (genetics)</term>
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<term>Adulte</term>
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<term>Génotype</term>
<term>Humains</term>
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<term>Indoles (effets indésirables)</term>
<term>Inhibiteurs de protéines kinases (administration et posologie)</term>
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<term>Résistance aux médicaments antinéoplasiques (génétique)</term>
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<front><div type="abstract" xml:lang="en">Several small studies indicated that the genotype of KIT or platelet-derived growth factor receptor-α (PDGFRA) contributes in part to the level of clinical effectiveness of sunitinib in gastrointestinal stromal tumor (GIST) patients. This study aimed to correlate KIT and PDGFRA mutational status with clinical outcome metrics (progression-free survival [PFS], overall survival [OS], objective response rate [ORR]) in a larger international patient population.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26772734</PMID>
<DateCreated><Year>2016</Year>
<Month>01</Month>
<Day>16</Day>
</DateCreated>
<DateCompleted><Year>2016</Year>
<Month>09</Month>
<Day>30</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>02</Month>
<Day>20</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1471-2407</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>16</Volume>
<PubDate><Year>2016</Year>
<Month>Jan</Month>
<Day>15</Day>
</PubDate>
</JournalIssue>
<Title>BMC cancer</Title>
<ISOAbbreviation>BMC Cancer</ISOAbbreviation>
</Journal>
<ArticleTitle>Correlation of KIT and PDGFRA mutational status with clinical benefit in patients with gastrointestinal stromal tumor treated with sunitinib in a worldwide treatment-use trial.</ArticleTitle>
<Pagination><MedlinePgn>22</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1186/s12885-016-2051-5</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Several small studies indicated that the genotype of KIT or platelet-derived growth factor receptor-α (PDGFRA) contributes in part to the level of clinical effectiveness of sunitinib in gastrointestinal stromal tumor (GIST) patients. This study aimed to correlate KIT and PDGFRA mutational status with clinical outcome metrics (progression-free survival [PFS], overall survival [OS], objective response rate [ORR]) in a larger international patient population.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">This is a non-interventional, retrospective analysis in patients with imatinib-resistant or intolerant GIST who were treated in a worldwide, open-label treatment-use study (Study 1036; NCT00094029) in which sunitinib was administered at a starting dose of 50 mg/day on a 4-week-on, 2-week-off schedule. Molecular status was obtained in local laboratories with tumor samples obtained either pre-imatinib, post-imatinib/pre-sunitinib, or post-sunitinib treatment, and all available data were used in the analyses regardless of collection time. The primary analysis compared PFS in patients with primary KIT exon 11 versus exon 9 mutations (using a 2-sided log-rank test) and secondary analyses compared OS (using the same test) and ORR (using a 2-sided Pearson χ(2) test) in the same molecular subgroups.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Of the 1124 sunitinib-treated patients in the treatment-use study, 230 (20%) were included in this analysis, and baseline characteristics were similar between the two study populations. Median PFS was 7.1 months. A significantly better PFS was observed in patients with a primary mutation in KIT exon 9 (n = 42) compared to those with a primary mutation in exon 11 (n = 143; hazard ratio = 0.59; 95 % confidence interval, 0.39-0.89; P = 0.011), with median PFS times of 12.3 and 7.0 months, respectively. Similarly, longer OS and higher ORR were observed in patients with a primary KIT mutation in exon 9 versus exon 11. The data available were limited to investigate the effects of additional KIT or PDGFRA mutations on the efficacy of sunitinib treatment.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">This large retrospective analysis confirms the prognostic significance of KIT mutation status in patients with GIST. This analysis also confirms the effectiveness of sunitinib as a post-imatinib therapy, regardless of mutational status.</AbstractText>
<AbstractText Label="TRIAL REGISTRATION" NlmCategory="BACKGROUND">NCT01459757.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Reichardt</LastName>
<ForeName>Peter</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Department of Interdisciplinary Oncology, HELIOS Klinikum Berlin-Buch, Schwanebecker Chaussee 50, 13125, Berlin, Germany. peter.reichardt@helios-kliniken.de.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Demetri</LastName>
<ForeName>George D</ForeName>
<Initials>GD</Initials>
<AffiliationInfo><Affiliation>Ludwig Center at Harvard and Dana-Farber Cancer Institute, Boston, MA, USA. george_demetri@dfci.harvard.edu.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gelderblom</LastName>
<ForeName>Hans</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Leiden University Medical Center, Leiden, The Netherlands. a.j.gelderblom@lumc.nl.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rutkowski</LastName>
<ForeName>Piotr</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland. rutkowskip@coi.waw.pl.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Im</LastName>
<ForeName>Seock-Ah</ForeName>
<Initials>SA</Initials>
<AffiliationInfo><Affiliation>Seoul National University Hospital, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea. moisa@snu.ac.kr.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gupta</LastName>
<ForeName>Sudeep</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Tata Memorial Centre, Mumbai, India. sudeepgupta04@yahoo.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kang</LastName>
<ForeName>Yoon-Koo</ForeName>
<Initials>YK</Initials>
<AffiliationInfo><Affiliation>Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. ykkang@amc.seoul.kr.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Schöffski</LastName>
<ForeName>Patrick</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>University Hospitals Leuven, Leuven Cancer Institute, and Laboratory of Experimental Oncology, KU Leuven, Leuven, Belgium. patrick.schoffski@uz.kuleuven.ac.be.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Schuette</LastName>
<ForeName>Jochen</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Hämatoonkologische Schwerpunktpraxis, Düsseldorf, Germany. jochen.schuette@uni-duisburg-essen.de.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Soulières</LastName>
<ForeName>Denis</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Centre Hospitalier de l'Université de Montreal, Montreal, QC, Canada. denis.soulieres@umontreal.ca.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Blay</LastName>
<ForeName>Jean-Yves</ForeName>
<Initials>JY</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, Université Claude Bernard, Lyon, France. jean-yves.blay@lyon.unicancer.fr.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Goldstein</LastName>
<ForeName>David</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Prince of Wales Hospital, Sydney, Australia. d.goldstein@unsw.edu.au.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fly</LastName>
<ForeName>Kolette</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Pfizer Oncology, Groton, CT, USA. kolette.d.fly@pfizer.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Huang</LastName>
<ForeName>Xin</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Pfizer Oncology, La Jolla, CA, USA. xin.huang@pfizer.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Corsaro</LastName>
<ForeName>Massimo</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Pfizer Oncology, Milan, Italy. massimo.corsaro@pfizer.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lechuga</LastName>
<ForeName>Maria Jose</ForeName>
<Initials>MJ</Initials>
<AffiliationInfo><Affiliation>Pfizer Oncology, Milan, Italy. mariajose.lechuga@pfizer.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Martini</LastName>
<ForeName>Jean-Francois</ForeName>
<Initials>JF</Initials>
<AffiliationInfo><Affiliation>Pfizer Oncology, La Jolla, CA, USA. jean-francois.martini@pfizer.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Heinrich</LastName>
<ForeName>Michael C</ForeName>
<Initials>MC</Initials>
<AffiliationInfo><Affiliation>VA Portland Health Care System and Oregon Health & Science University, Portland, OR, USA. heinrich@ohsu.edu.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName>
<AccessionNumberList><AccessionNumber>NCT01459757</AccessionNumber>
</AccessionNumberList>
</DataBank>
</DataBankList>
<GrantList CompleteYN="Y"><Grant><GrantID>P50 CA127003</GrantID>
<Acronym>CA</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>1P50CA127003-05</GrantID>
<Acronym>CA</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
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<PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>01</Month>
<Day>15</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>BMC Cancer</MedlineTA>
<NlmUniqueID>100967800</NlmUniqueID>
<ISSNLinking>1471-2407</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D007211">Indoles</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D047428">Protein Kinase Inhibitors</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D011758">Pyrroles</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.10.1</RegistryNumber>
<NameOfSubstance UI="D019009">Proto-Oncogene Proteins c-kit</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.10.1</RegistryNumber>
<NameOfSubstance UI="D020796">Receptor, Platelet-Derived Growth Factor alpha</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>V99T50803M</RegistryNumber>
<NameOfSubstance UI="C473478">sunitinib</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>J Pathol. 2008 Sep;216(1):64-74</RefSource>
<PMID Version="1">18623623</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Clin Cancer Res. 2005 Jun 1;11(11):4182-90</RefSource>
<PMID Version="1">15930355</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Int J Clin Oncol. 2009 Apr;14(2):143-9</RefSource>
<PMID Version="1">19390946</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Clin Oncol. 2006 Oct 10;24(29):4764-74</RefSource>
<PMID Version="1">16954519</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>BMC Cancer. 2012;12:107</RefSource>
<PMID Version="1">22439647</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Clin Oncol. 2008 Nov 20;26(33):5352-9</RefSource>
<PMID Version="1">18955458</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cell. 2007 Jul 27;130(2):323-34</RefSource>
<PMID Version="1">17662946</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Clin Oncol. 2008 Feb 1;26(4):620-5</RefSource>
<PMID Version="1">18235121</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Histopathology. 2008 Sep;53(3):245-66</RefSource>
<PMID Version="1">18312355</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Invest New Drugs. 2012 Apr;30(2):819-27</RefSource>
<PMID Version="1">21104107</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Natl Cancer Inst. 2000 Feb 2;92(3):205-16</RefSource>
<PMID Version="1">10655437</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cancer Res. 2004 Sep 1;64(17):5913-9</RefSource>
<PMID Version="1">15342366</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Clin Endocrinol Metab. 2006 Oct;91(10):4070-6</RefSource>
<PMID Version="1">16849418</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Clin Oncol. 2005 Aug 20;23(24):5795-804</RefSource>
<PMID Version="1">16110036</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2002 Aug 15;347(7):472-80</RefSource>
<PMID Version="1">12181401</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Science. 2003 Jan 31;299(5607):708-10</RefSource>
<PMID Version="1">12522257</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Med Oncol. 2013 Jun;30(2):522</RefSource>
<PMID Version="1">23456621</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Clin Oncol. 2008 Nov 20;26(33):5360-7</RefSource>
<PMID Version="1">18955451</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Ther Adv Med Oncol. 2014 May;6(3):115-27</RefSource>
<PMID Version="1">24790651</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Pathol. 2002 May;160(5):1567-72</RefSource>
<PMID Version="1">12000708</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Clin Oncol. 2003 Dec 1;21(23):4342-9</RefSource>
<PMID Version="1">14645423</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Gastrointestin Liver Dis. 2013 Dec;22(4):413-8</RefSource>
<PMID Version="1">24369323</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cancer. 2015 May 1;121(9):1405-13</RefSource>
<PMID Version="1">25641662</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mol Cancer Ther. 2003 May;2(5):471-8</RefSource>
<PMID Version="1">12748309</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Eur J Cancer. 2009 Jul;45(11):1959-68</RefSource>
<PMID Version="1">19282169</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Rev Cancer. 2004 Sep;4(9):718-27</RefSource>
<PMID Version="1">15343278</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1542-7</RefSource>
<PMID Version="1">19164557</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Clin Cancer Res. 2004 May 15;10(10):3282-90</RefSource>
<PMID Version="1">15161681</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Blood. 2003 May 1;101(9):3597-605</RefSource>
<PMID Version="1">12531805</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Lancet. 2006 Oct 14;368(9544):1329-38</RefSource>
<PMID Version="1">17046465</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Clin Cancer Res. 2012 Jun 1;18(11):3170-9</RefSource>
<PMID Version="1">22661587</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cancer Res. 2001 Nov 15;61(22):8118-21</RefSource>
<PMID Version="1">11719439</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Surg Pathol. 2013 Nov;37(11):1648-59</RefSource>
<PMID Version="1">24061512</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>World J Gastroenterol. 2012 Feb 21;18(7):698-703</RefSource>
<PMID Version="1">22363143</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Clin Cancer Res. 2003 Jan;9(1):327-37</RefSource>
<PMID Version="1">12538485</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Annu Rev Pathol. 2008;3:557-86</RefSource>
<PMID Version="1">18039140</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Clin Cancer Res. 2009 Sep 15;15(18):5902-9</RefSource>
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