Differential proteomics reveals novel insights into Nosema-honey bee interactions.
Identifieur interne : 002050 ( PubMed/Checkpoint ); précédent : 002049; suivant : 002051Differential proteomics reveals novel insights into Nosema-honey bee interactions.
Auteurs : Christoph Kurze [États-Unis] ; Ryan Dosselli [Australie] ; Julia Grassl [Australie] ; Yves Le Conte [France] ; Per Kryger [Danemark] ; Boris Baer [Australie] ; Robin F A. Moritz [Afrique du Sud]Source :
- Insect biochemistry and molecular biology [ 1879-0240 ] ; 2016.
Descripteurs français
- KwdFr :
- Abeilles (génétique), Abeilles (microbiologie), Animaux, Interactions hôte-pathogène, Nosema (génétique), Nosema (physiologie), Protéines d'insecte (génétique), Protéines d'insecte (métabolisme), Protéines fongiques (génétique), Protéines fongiques (métabolisme), Protéome, Protéomique, Spectrométrie de masse, Tube digestif (microbiologie).
- MESH :
- génétique : Abeilles, Nosema, Protéines d'insecte, Protéines fongiques.
- microbiologie : Abeilles, Tube digestif.
- métabolisme : Protéines d'insecte, Protéines fongiques.
- physiologie : Nosema.
- Animaux, Interactions hôte-pathogène, Protéome, Protéomique, Spectrométrie de masse.
English descriptors
- KwdEn :
- Animals, Bees (genetics), Bees (microbiology), Fungal Proteins (genetics), Fungal Proteins (metabolism), Gastrointestinal Tract (microbiology), Host-Pathogen Interactions, Insect Proteins (genetics), Insect Proteins (metabolism), Mass Spectrometry, Nosema (genetics), Nosema (physiology), Proteome, Proteomics.
- MESH :
- chemical , genetics : Fungal Proteins, Insect Proteins.
- genetics : Bees, Nosema.
- chemical , metabolism : Fungal Proteins, Insect Proteins.
- microbiology : Bees, Gastrointestinal Tract.
- physiology : Nosema.
- Animals, Host-Pathogen Interactions, Mass Spectrometry, Proteome, Proteomics.
Abstract
Host manipulation is a common strategy by parasites to reduce host defense responses, enhance development, host exploitation, reproduction and, ultimately, transmission success. As these parasitic modifications can reduce host fitness, increased selection pressure may result in reciprocal adaptations of the host. Whereas the majority of studies on host manipulation have explored resistance against parasites (i.e. ability to prevent or limit an infection), data describing tolerance mechanisms (i.e. ability to limit harm of an infection) are scarce. By comparing differential protein abundance, we provide evidence of host-parasite interactions in the midgut proteomes of N. ceranae-infected and uninfected honey bees from both Nosema-tolerant and Nosema-sensitive lineages. We identified 16 proteins out of 661 protein spots that were differentially abundant between experimental groups. In general, infections of Nosema resulted in an up-regulation of the bee's energy metabolism. Additionally, we identified 8 proteins that were differentially abundant between tolerant and sensitive honey bees regardless of the Nosema infection. Those proteins were linked to metabolism, response to oxidative stress and apoptosis. In addition to bee proteins, we also identified 3 Nosema ceranae proteins. Interestingly, abundance of two of these Nosema proteins were significantly higher in infected Nosema-sensitive honeybees relative to the infected Nosema-tolerant lineage. This may provide a novel candidate for studying the molecular interplay between N. ceranae and its honey bee host in more detail.
DOI: 10.1016/j.ibmb.2016.10.005
PubMed: 27784614
Affiliations:
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Moritz</name><affiliation wicri:level="1"><nlm:affiliation>Martin-Luther-Universität Halle-Wittenberg, Institute for Biology/Molecular Ecology, Hoher Weg 4, 06120 Halle (Saale), Germany; German Institute for Integrative Biodiversity Research (iDiv), Bio City, 04103 Leipzig, Germany; University of Pretoria, Department of Zoology and Entomology, Pretoria, 0002, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Martin-Luther-Universität Halle-Wittenberg, Institute for Biology/Molecular Ecology, Hoher Weg 4, 06120 Halle (Saale), Germany; German Institute for Integrative Biodiversity Research (iDiv), Bio City, 04103 Leipzig, Germany; University of Pretoria, Department of Zoology and Entomology, Pretoria, 0002</wicri:regionArea><wicri:noRegion>0002</wicri:noRegion></affiliation></author></analytic><series><title level="j">Insect biochemistry and molecular biology</title><idno type="eISSN">1879-0240</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Bees (genetics)</term><term>Bees (microbiology)</term><term>Fungal Proteins (genetics)</term><term>Fungal Proteins (metabolism)</term><term>Gastrointestinal Tract (microbiology)</term><term>Host-Pathogen Interactions</term><term>Insect Proteins (genetics)</term><term>Insect Proteins (metabolism)</term><term>Mass Spectrometry</term><term>Nosema (genetics)</term><term>Nosema (physiology)</term><term>Proteome</term><term>Proteomics</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Abeilles (génétique)</term><term>Abeilles (microbiologie)</term><term>Animaux</term><term>Interactions hôte-pathogène</term><term>Nosema (génétique)</term><term>Nosema (physiologie)</term><term>Protéines d'insecte (génétique)</term><term>Protéines d'insecte (métabolisme)</term><term>Protéines fongiques (génétique)</term><term>Protéines fongiques (métabolisme)</term><term>Protéome</term><term>Protéomique</term><term>Spectrométrie de masse</term><term>Tube digestif (microbiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Fungal Proteins</term><term>Insect Proteins</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Bees</term><term>Nosema</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Abeilles</term><term>Nosema</term><term>Protéines d'insecte</term><term>Protéines fongiques</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Fungal Proteins</term><term>Insect Proteins</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Abeilles</term><term>Tube digestif</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Bees</term><term>Gastrointestinal Tract</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéines d'insecte</term><term>Protéines fongiques</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Nosema</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Nosema</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Host-Pathogen Interactions</term><term>Mass Spectrometry</term><term>Proteome</term><term>Proteomics</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Interactions hôte-pathogène</term><term>Protéome</term><term>Protéomique</term><term>Spectrométrie de masse</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Host manipulation is a common strategy by parasites to reduce host defense responses, enhance development, host exploitation, reproduction and, ultimately, transmission success. As these parasitic modifications can reduce host fitness, increased selection pressure may result in reciprocal adaptations of the host. Whereas the majority of studies on host manipulation have explored resistance against parasites (i.e. ability to prevent or limit an infection), data describing tolerance mechanisms (i.e. ability to limit harm of an infection) are scarce. By comparing differential protein abundance, we provide evidence of host-parasite interactions in the midgut proteomes of N. ceranae-infected and uninfected honey bees from both Nosema-tolerant and Nosema-sensitive lineages. We identified 16 proteins out of 661 protein spots that were differentially abundant between experimental groups. In general, infections of Nosema resulted in an up-regulation of the bee's energy metabolism. Additionally, we identified 8 proteins that were differentially abundant between tolerant and sensitive honey bees regardless of the Nosema infection. Those proteins were linked to metabolism, response to oxidative stress and apoptosis. In addition to bee proteins, we also identified 3 Nosema ceranae proteins. Interestingly, abundance of two of these Nosema proteins were significantly higher in infected Nosema-sensitive honeybees relative to the infected Nosema-tolerant lineage. This may provide a novel candidate for studying the molecular interplay between N. ceranae and its honey bee host in more detail.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27784614</PMID><DateCreated><Year>2016</Year><Month>10</Month><Day>27</Day></DateCreated><DateCompleted><Year>2017</Year><Month>09</Month><Day>06</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>06</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-0240</ISSN><JournalIssue CitedMedium="Internet"><Volume>79</Volume><PubDate><Year>2016</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Insect biochemistry and molecular biology</Title><ISOAbbreviation>Insect Biochem. Mol. Biol.</ISOAbbreviation></Journal><ArticleTitle>Differential proteomics reveals novel insights into Nosema-honey bee interactions.</ArticleTitle><Pagination><MedlinePgn>42-49</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0965-1748(16)30151-5</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ibmb.2016.10.005</ELocationID><Abstract><AbstractText>Host manipulation is a common strategy by parasites to reduce host defense responses, enhance development, host exploitation, reproduction and, ultimately, transmission success. As these parasitic modifications can reduce host fitness, increased selection pressure may result in reciprocal adaptations of the host. Whereas the majority of studies on host manipulation have explored resistance against parasites (i.e. ability to prevent or limit an infection), data describing tolerance mechanisms (i.e. ability to limit harm of an infection) are scarce. By comparing differential protein abundance, we provide evidence of host-parasite interactions in the midgut proteomes of N. ceranae-infected and uninfected honey bees from both Nosema-tolerant and Nosema-sensitive lineages. We identified 16 proteins out of 661 protein spots that were differentially abundant between experimental groups. In general, infections of Nosema resulted in an up-regulation of the bee's energy metabolism. Additionally, we identified 8 proteins that were differentially abundant between tolerant and sensitive honey bees regardless of the Nosema infection. Those proteins were linked to metabolism, response to oxidative stress and apoptosis. In addition to bee proteins, we also identified 3 Nosema ceranae proteins. Interestingly, abundance of two of these Nosema proteins were significantly higher in infected Nosema-sensitive honeybees relative to the infected Nosema-tolerant lineage. This may provide a novel candidate for studying the molecular interplay between N. ceranae and its honey bee host in more detail.</AbstractText><CopyrightInformation>Copyright © 2016 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kurze</LastName><ForeName>Christoph</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Martin-Luther-Universität Halle-Wittenberg, Institute for Biology/Molecular Ecology, Hoher Weg 4, 06120 Halle (Saale), Germany; The University of Western Australia, Centre for Integrative Bee Research (CIBER) and ARC Centre of Excellence in Plant Energy Biology, Bayliss Building (M316), Crawley, Western Australia 6009, Australia; Pennsylvania State University, Center for Infectious Disease Dynamics, W249 Millennium Science Complex, University Park, PA 16802, United States. Electronic address: christoph.kurze@zoologie.uni-halle.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dosselli</LastName><ForeName>Ryan</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>The University of Western Australia, Centre for Integrative Bee Research (CIBER) and ARC Centre of Excellence in Plant Energy Biology, Bayliss Building (M316), Crawley, Western Australia 6009, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grassl</LastName><ForeName>Julia</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>The University of Western Australia, Centre for Integrative Bee Research (CIBER) and ARC Centre of Excellence in Plant Energy Biology, Bayliss Building (M316), Crawley, Western Australia 6009, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Le Conte</LastName><ForeName>Yves</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>INRA, UR 406 Abeilles et Environnement, Site Agroparc, 84914 Avignon Cedex 9, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kryger</LastName><ForeName>Per</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Aarhus University, Department of Agroecology/Section of Entomology and Plant Pathology, Flakkebjerg, 4200, Slagelse, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baer</LastName><ForeName>Boris</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>The University of Western Australia, Centre for Integrative Bee Research (CIBER) and ARC Centre of Excellence in Plant Energy Biology, Bayliss Building (M316), Crawley, Western Australia 6009, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moritz</LastName><ForeName>Robin F A</ForeName><Initials>RF</Initials><AffiliationInfo><Affiliation>Martin-Luther-Universität Halle-Wittenberg, Institute for Biology/Molecular Ecology, Hoher Weg 4, 06120 Halle (Saale), Germany; German Institute for Integrative Biodiversity Research (iDiv), Bio City, 04103 Leipzig, Germany; University of Pretoria, Department of Zoology and Entomology, Pretoria, 0002, South Africa.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>10</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Insect Biochem Mol Biol</MedlineTA><NlmUniqueID>9207282</NlmUniqueID><ISSNLinking>0965-1748</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005656">Fungal Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019476">Insect Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D020543">Proteome</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001516" MajorTopicYN="N">Bees</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005656" MajorTopicYN="N">Fungal Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D041981" MajorTopicYN="N">Gastrointestinal Tract</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D054884" MajorTopicYN="N">Host-Pathogen Interactions</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019476" MajorTopicYN="N">Insect Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013058" MajorTopicYN="N">Mass Spectrometry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016818" MajorTopicYN="N">Nosema</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020543" MajorTopicYN="Y">Proteome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D040901" MajorTopicYN="N">Proteomics</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Apis mellifera</Keyword><Keyword MajorTopicYN="N">Coevolution</Keyword><Keyword MajorTopicYN="N">Host-parasite interaction</Keyword><Keyword MajorTopicYN="N">Nosema ceranae</Keyword><Keyword MajorTopicYN="N">Proteome</Keyword><Keyword MajorTopicYN="N">Tolerance</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>07</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>10</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>10</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>10</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>9</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>11</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27784614</ArticleId><ArticleId IdType="pii">S0965-1748(16)30151-5</ArticleId><ArticleId IdType="doi">10.1016/j.ibmb.2016.10.005</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Afrique du Sud</li><li>Australie</li><li>Danemark</li><li>France</li><li>États-Unis</li></country><region><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Kurze, Christoph" sort="Kurze, Christoph" uniqKey="Kurze C" first="Christoph" last="Kurze">Christoph Kurze</name></region></country><country name="Australie"><noRegion><name sortKey="Dosselli, Ryan" sort="Dosselli, Ryan" uniqKey="Dosselli R" first="Ryan" last="Dosselli">Ryan Dosselli</name></noRegion><name sortKey="Baer, Boris" sort="Baer, Boris" uniqKey="Baer B" first="Boris" last="Baer">Boris Baer</name><name sortKey="Grassl, Julia" sort="Grassl, Julia" uniqKey="Grassl J" first="Julia" last="Grassl">Julia Grassl</name></country><country name="France"><noRegion><name sortKey="Le Conte, Yves" sort="Le Conte, Yves" uniqKey="Le Conte Y" first="Yves" last="Le Conte">Yves Le Conte</name></noRegion></country><country name="Danemark"><noRegion><name sortKey="Kryger, Per" sort="Kryger, Per" uniqKey="Kryger P" first="Per" last="Kryger">Per Kryger</name></noRegion></country><country name="Afrique du Sud"><noRegion><name sortKey="Moritz, Robin F A" sort="Moritz, Robin F A" uniqKey="Moritz R" first="Robin F A" last="Moritz">Robin F A. 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