ESMO consensus guidelines for the management of patients with metastatic colorectal cancer.
Identifieur interne : 002009 ( PubMed/Checkpoint ); précédent : 002008; suivant : 002010ESMO consensus guidelines for the management of patients with metastatic colorectal cancer.
Auteurs : E. Van Cutsem ; A. Cervantes [Espagne] ; R. Adam [France] ; A. Sobrero [Italie] ; J H Van Krieken [Pays-Bas] ; D. Aderka [Israël] ; E. Aranda Aguilar [Espagne] ; A. Bardelli [Italie] ; A. Benson [États-Unis] ; G. Bodoky [Hongrie] ; F. Ciardiello [Italie] ; A. D'Hoore [Belgique] ; E. Diaz-Rubio [Espagne] ; J-Y Douillard ; M. Ducreux [France] ; A. Falcone [Italie] ; A. Grothey [États-Unis] ; T. Gruenberger [Autriche] ; K. Haustermans [Belgique] ; V. Heinemann [Allemagne] ; P. Hoff [Brésil] ; C-H Köhne [Allemagne] ; R. Labianca [Italie] ; P. Laurent-Puig [France] ; B. Ma [Hong Kong] ; T. Maughan [Royaume-Uni] ; K. Muro [Japon] ; N. Normanno [Italie] ; P. Österlund [Finlande] ; W J G. Oyen [Royaume-Uni] ; D. Papamichael [Chypre (pays)] ; G. Pentheroudakis [Grèce] ; P. Pfeiffer [Danemark] ; T J Price [Australie] ; C. Punt [Pays-Bas] ; J. Ricke [Allemagne] ; A. Roth [Suisse] ; R. Salazar [Espagne] ; W. Scheithauer [Autriche] ; H J Schmoll [Allemagne] ; J. Tabernero [Espagne] ; J. Taïeb [France] ; S. Tejpar [Belgique] ; H. Wasan [Royaume-Uni] ; T. Yoshino [Japon] ; A. Zaanan [France] ; D. Arnold [Portugal]Source :
- Annals of oncology : official journal of the European Society for Medical Oncology [ 1569-8041 ] ; 2016.
Abstract
Colorectal cancer (CRC) is one of the most common malignancies in Western countries. Over the last 20 years, and the last decade in particular, the clinical outcome for patients with metastatic CRC (mCRC) has improved greatly due not only to an increase in the number of patients being referred for and undergoing surgical resection of their localised metastatic disease but also to a more strategic approach to the delivery of systemic therapy and an expansion in the use of ablative techniques. This reflects the increase in the number of patients that are being managed within a multidisciplinary team environment and specialist cancer centres, and the emergence over the same time period not only of improved imaging techniques but also prognostic and predictive molecular markers. Treatment decisions for patients with mCRC must be evidence-based. Thus, these ESMO consensus guidelines have been developed based on the current available evidence to provide a series of evidence-based recommendations to assist in the treatment and management of patients with mCRC in this rapidly evolving treatment setting.
DOI: 10.1093/annonc/mdw235
PubMed: 27380959
Affiliations:
- Allemagne, Australie, Autriche, Belgique, Brésil, Chypre (pays), Danemark, Espagne, Finlande, France, Grèce, Hong Kong, Hongrie, Israël, Italie, Japon, Pays-Bas, Portugal, Royaume-Uni, Suisse, États-Unis
- Angleterre, Bavière, Catalogne, Communauté de Madrid, District de Haute-Bavière, Grand Londres, Gueldre, Hollande-Septentrionale, Hongrie centrale, Illinois, Oxfordshire, Piémont, Saxe-Anhalt, Toscane, Vienne (Autriche), État de São Paulo, Île-de-France
- Amsterdam, Barcelone, Budapest, Chicago, Londres, Madrid, Magdebourg, Munich, Nimègue, Oxford, Paris, Pise, Sha Tin, São Paulo, Turin, Vienne (Autriche)
- Université chinoise de Hong Kong, Université d'Amsterdam, Université d'Oxford, Université de Pise, Université de São Paulo
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Maughan</name><affiliation wicri:level="4"><nlm:affiliation>CRUK/MRC Oxford Institute for Radiation Oncology, Gray Laboratories, University of Oxford, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>CRUK/MRC Oxford Institute for Radiation Oncology, Gray Laboratories, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Muro, K" sort="Muro, K" uniqKey="Muro K" first="K" last="Muro">K. Muro</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Oncology and Outpatient Treatment Center, Aichi Cancer Center Hospital, Nagoya, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Clinical Oncology and Outpatient Treatment Center, Aichi Cancer Center Hospital, Nagoya</wicri:regionArea><wicri:noRegion>Nagoya</wicri:noRegion></affiliation></author><author><name sortKey="Normanno, N" sort="Normanno, N" uniqKey="Normanno N" first="N" last="Normanno">N. Normanno</name><affiliation wicri:level="1"><nlm:affiliation>Cell Biology and Biotherapy Unit, I.N.T. Fondazione G. Pascale, Napoli, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Cell Biology and Biotherapy Unit, I.N.T. Fondazione G. 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Oyen</name><affiliation wicri:level="3"><nlm:affiliation>The Institute of Cancer Research and The Royal Marsden Hospital, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Institute of Cancer Research and The Royal Marsden Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Papamichael, D" sort="Papamichael, D" uniqKey="Papamichael D" first="D" last="Papamichael">D. Papamichael</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Bank of Cyprus Oncology Centre, Nicosia, Cyprus.</nlm:affiliation><country xml:lang="fr">Chypre (pays)</country><wicri:regionArea>Department of Medical Oncology, Bank of Cyprus Oncology Centre, Nicosia</wicri:regionArea><wicri:noRegion>Nicosia</wicri:noRegion></affiliation></author><author><name sortKey="Pentheroudakis, G" sort="Pentheroudakis, G" uniqKey="Pentheroudakis G" first="G" last="Pentheroudakis">G. Pentheroudakis</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, University of Ioannina, Ioannina, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Medical Oncology, University of Ioannina, Ioannina</wicri:regionArea><wicri:noRegion>Ioannina</wicri:noRegion></affiliation></author><author><name sortKey="Pfeiffer, P" sort="Pfeiffer, P" uniqKey="Pfeiffer P" first="P" last="Pfeiffer">P. Pfeiffer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, Odense University Hospital, Odense, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Oncology, Odense University Hospital, Odense</wicri:regionArea><wicri:noRegion>Odense</wicri:noRegion></affiliation></author><author><name sortKey="Price, T J" sort="Price, T J" uniqKey="Price T" first="T J" last="Price">T J Price</name><affiliation wicri:level="1"><nlm:affiliation>Haematology and Medical Oncology Unit, Queen Elizabeth Hospital, Woodville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Haematology and Medical Oncology Unit, Queen Elizabeth Hospital, Woodville</wicri:regionArea><wicri:noRegion>Woodville</wicri:noRegion></affiliation></author><author><name sortKey="Punt, C" sort="Punt, C" uniqKey="Punt C" first="C" last="Punt">C. 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Ricke</name><affiliation wicri:level="3"><nlm:affiliation>Department of Radiology and Nuclear Medicine, University Clinic Magdeburg, Magdeburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Radiology and Nuclear Medicine, University Clinic Magdeburg, Magdeburg</wicri:regionArea><placeName><region type="land" nuts="2">Saxe-Anhalt</region><settlement type="city">Magdebourg</settlement></placeName></affiliation></author><author><name sortKey="Roth, A" sort="Roth, A" uniqKey="Roth A" first="A" last="Roth">A. Roth</name><affiliation wicri:level="1"><nlm:affiliation>Digestive Tumors Unit, Geneva University Hospitals (HUG), Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Digestive Tumors Unit, Geneva University Hospitals (HUG), Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Salazar, R" sort="Salazar, R" uniqKey="Salazar R" first="R" last="Salazar">R. Salazar</name><affiliation wicri:level="3"><nlm:affiliation>Catalan Institute of Oncology (ICO), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Catalan Institute of Oncology (ICO), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Scheithauer, W" sort="Scheithauer, W" uniqKey="Scheithauer W" first="W" last="Scheithauer">W. Scheithauer</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine I and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Internal Medicine I and Comprehensive Cancer Center, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Schmoll, H J" sort="Schmoll, H J" uniqKey="Schmoll H" first="H J" last="Schmoll">H J Schmoll</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine IV, University Clinic Halle, Martin-Luther-University Halle-Wittenberg, Halle, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine IV, University Clinic Halle, Martin-Luther-University Halle-Wittenberg, Halle</wicri:regionArea><wicri:noRegion>Halle</wicri:noRegion><wicri:noRegion>Halle</wicri:noRegion><wicri:noRegion>Halle</wicri:noRegion></affiliation></author><author><name sortKey="Tabernero, J" sort="Tabernero, J" uniqKey="Tabernero J" first="J" last="Tabernero">J. Tabernero</name><affiliation wicri:level="3"><nlm:affiliation>Medical Oncology Department, Vall d' Hebron University Hospital, Vall d'Hebron Institute of Oncology (V.H.I.O.), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Medical Oncology Department, Vall d' Hebron University Hospital, Vall d'Hebron Institute of Oncology (V.H.I.O.), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Taieb, J" sort="Taieb, J" uniqKey="Taieb J" first="J" last="Taïeb">J. Taïeb</name><affiliation wicri:level="3"><nlm:affiliation>Digestive Oncology Department, European Hospital Georges Pompidou, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Digestive Oncology Department, European Hospital Georges Pompidou, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Tejpar, S" sort="Tejpar, S" uniqKey="Tejpar S" first="S" last="Tejpar">S. Tejpar</name><affiliation wicri:level="1"><nlm:affiliation>Digestive Oncology, University Hospitals Gasthuisberg Leuven and KU Leuven, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Digestive Oncology, University Hospitals Gasthuisberg Leuven and KU Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Wasan, H" sort="Wasan, H" uniqKey="Wasan H" first="H" last="Wasan">H. Wasan</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cancer Medicine, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Cancer Medicine, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Yoshino, T" sort="Yoshino, T" uniqKey="Yoshino T" first="T" last="Yoshino">T. Yoshino</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Chiba, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Chiba</wicri:regionArea><wicri:noRegion>Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Zaanan, A" sort="Zaanan, A" uniqKey="Zaanan A" first="A" last="Zaanan">A. Zaanan</name><affiliation wicri:level="3"><nlm:affiliation>Digestive Oncology Department, European Hospital Georges Pompidou, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Digestive Oncology Department, European Hospital Georges Pompidou, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Arnold, D" sort="Arnold, D" uniqKey="Arnold D" first="D" last="Arnold">D. Arnold</name><affiliation wicri:level="1"><nlm:affiliation>Instituto CUF de Oncologia (ICO), Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Instituto CUF de Oncologia (ICO), Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27380959</idno><idno type="pmid">27380959</idno><idno type="doi">10.1093/annonc/mdw235</idno><idno type="wicri:Area/PubMed/Corpus">001A38</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001A38</idno><idno type="wicri:Area/PubMed/Curation">001A14</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001A14</idno><idno type="wicri:Area/PubMed/Checkpoint">001A14</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001A14</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">ESMO consensus guidelines for the management of patients with metastatic colorectal cancer.</title><author><name sortKey="Van Cutsem, E" sort="Van Cutsem, E" uniqKey="Van Cutsem E" first="E" last="Van Cutsem">E. Van Cutsem</name><affiliation><nlm:affiliation>Digestive Oncology, University Hospitals Gasthuisberg Leuven and KU Leuven, Leuven, Belgium clinicalguidelines@esmo.org.</nlm:affiliation><wicri:noCountry code="subField">Belgium clinicalguidelines@esmo.org.</wicri:noCountry></affiliation></author><author><name sortKey="Cervantes, A" sort="Cervantes, A" uniqKey="Cervantes A" first="A" last="Cervantes">A. Cervantes</name><affiliation wicri:level="1"><nlm:affiliation>Medical Oncology Department, INCLIVA University of Valencia, Valencia, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Medical Oncology Department, INCLIVA University of Valencia, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Adam, R" sort="Adam, R" uniqKey="Adam R" first="R" last="Adam">R. Adam</name><affiliation wicri:level="1"><nlm:affiliation>Hepato-Biliary Centre, Paul Brousse Hospital, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hepato-Biliary Centre, Paul Brousse Hospital, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Sobrero, A" sort="Sobrero, A" uniqKey="Sobrero A" first="A" last="Sobrero">A. Sobrero</name><affiliation wicri:level="1"><nlm:affiliation>Medical Oncology, IRCCS San Martino Hospital, Genova, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Medical Oncology, IRCCS San Martino Hospital, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation></author><author><name sortKey="Van Krieken, J H" sort="Van Krieken, J H" uniqKey="Van Krieken J" first="J H" last="Van Krieken">J H Van Krieken</name><affiliation wicri:level="3"><nlm:affiliation>Research Institute for Oncology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Research Institute for Oncology, Radboud University Nijmegen Medical Center, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Aderka, D" sort="Aderka, D" uniqKey="Aderka D" first="D" last="Aderka">D. Aderka</name><affiliation wicri:level="1"><nlm:affiliation>Division of Oncology, Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Division of Oncology, Sheba Medical Center, Tel Aviv University, Tel Aviv</wicri:regionArea><wicri:noRegion>Tel Aviv</wicri:noRegion></affiliation></author><author><name sortKey="Aranda Aguilar, E" sort="Aranda Aguilar, E" uniqKey="Aranda Aguilar E" first="E" last="Aranda Aguilar">E. Aranda Aguilar</name><affiliation wicri:level="1"><nlm:affiliation>Medical Oncology Department, University Hospital Reina Sofia, Cordoba, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Medical Oncology Department, University Hospital Reina Sofia, Cordoba</wicri:regionArea><wicri:noRegion>Cordoba</wicri:noRegion></affiliation></author><author><name sortKey="Bardelli, A" sort="Bardelli, A" uniqKey="Bardelli A" first="A" last="Bardelli">A. Bardelli</name><affiliation wicri:level="3"><nlm:affiliation>School of Medicine, University of Turin, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>School of Medicine, University of Turin, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Benson, A" sort="Benson, A" uniqKey="Benson A" first="A" last="Benson">A. Benson</name><affiliation wicri:level="3"><nlm:affiliation>Division of Hematology/Oncology, Northwestern Medical Group, Chicago, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Hematology/Oncology, Northwestern Medical Group, Chicago</wicri:regionArea><placeName><settlement type="city">Chicago</settlement><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Bodoky, G" sort="Bodoky, G" uniqKey="Bodoky G" first="G" last="Bodoky">G. Bodoky</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oncology, St László Hospital, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Oncology, St László Hospital, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Ciardiello, F" sort="Ciardiello, F" uniqKey="Ciardiello F" first="F" last="Ciardiello">F. Ciardiello</name><affiliation wicri:level="1"><nlm:affiliation>Division of Medical Oncology, Seconda Università di Napoli, Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Medical Oncology, Seconda Università di Napoli, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="D Hoore, A" sort="D Hoore, A" uniqKey="D Hoore A" first="A" last="D'Hoore">A. D'Hoore</name><affiliation wicri:level="1"><nlm:affiliation>Abdominal Surgery, University Hospitals Gasthuisberg Leuven and KU Leuven, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Abdominal Surgery, University Hospitals Gasthuisberg Leuven and KU Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Diaz Rubio, E" sort="Diaz Rubio, E" uniqKey="Diaz Rubio E" first="E" last="Diaz-Rubio">E. Diaz-Rubio</name><affiliation wicri:level="3"><nlm:affiliation>Medical Oncology Department, Hospital Clínico San Carlos, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Medical Oncology Department, Hospital Clínico San Carlos, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Douillard, J Y" sort="Douillard, J Y" uniqKey="Douillard J" first="J-Y" last="Douillard">J-Y Douillard</name><affiliation><nlm:affiliation>Medical Oncology, Institut de Cancérologie de l'Ouest (ICO), St Herblain.</nlm:affiliation><wicri:noCountry code="subField">St Herblain</wicri:noCountry></affiliation></author><author><name sortKey="Ducreux, M" sort="Ducreux, M" uniqKey="Ducreux M" first="M" last="Ducreux">M. Ducreux</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Gustave Roussy, Université Paris-Saclay, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Medical Oncology, Gustave Roussy, Université Paris-Saclay, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Falcone, A" sort="Falcone, A" uniqKey="Falcone A" first="A" last="Falcone">A. Falcone</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medical Oncology, University of Pisa, Pisa, Italy Division of Medical Oncology, Department of Oncology, University Hospital 'S. Chiara', Istituto Toscano Tumori, Pisa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical Oncology, University of Pisa, Pisa, Italy Division of Medical Oncology, Department of Oncology, University Hospital 'S. Chiara', Istituto Toscano Tumori, Pisa</wicri:regionArea><placeName><settlement type="city">Pise</settlement><region nuts="2">Toscane</region><settlement type="city">Pise</settlement></placeName><orgName type="university">Université de Pise</orgName></affiliation></author><author><name sortKey="Grothey, A" sort="Grothey, A" uniqKey="Grothey A" first="A" last="Grothey">A. Grothey</name><affiliation wicri:level="1"><nlm:affiliation>Division of Medical Oncology, Mayo Clinic, Rochester, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Medical Oncology, Mayo Clinic, Rochester</wicri:regionArea><wicri:noRegion>Rochester</wicri:noRegion></affiliation></author><author><name sortKey="Gruenberger, T" sort="Gruenberger, T" uniqKey="Gruenberger T" first="T" last="Gruenberger">T. Gruenberger</name><affiliation wicri:level="3"><nlm:affiliation>Department of Surgery I, Rudolfstiftung Hospital, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Surgery I, Rudolfstiftung Hospital, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Haustermans, K" sort="Haustermans, K" uniqKey="Haustermans K" first="K" last="Haustermans">K. Haustermans</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiation Oncology, University Hospitals Gasthuisberg and KU Leuven, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Radiation Oncology, University Hospitals Gasthuisberg and KU Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Heinemann, V" sort="Heinemann, V" uniqKey="Heinemann V" first="V" last="Heinemann">V. Heinemann</name><affiliation wicri:level="3"><nlm:affiliation>Comprehensive Cancer Center, University Clinic Munich, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Comprehensive Cancer Center, University Clinic Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Hoff, P" sort="Hoff, P" uniqKey="Hoff P" first="P" last="Hoff">P. Hoff</name><affiliation wicri:level="4"><nlm:affiliation>Instituto do Câncer do Estado de São Paulo, University of São Paulo, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Instituto do Câncer do Estado de São Paulo, University of São Paulo, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region><settlement type="city">São Paulo</settlement></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Kohne, C H" sort="Kohne, C H" uniqKey="Kohne C" first="C-H" last="Köhne">C-H Köhne</name><affiliation wicri:level="1"><nlm:affiliation>Northwest German Cancer Center, University Campus Klinikum Oldenburg, Oldenburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Northwest German Cancer Center, University Campus Klinikum Oldenburg, Oldenburg</wicri:regionArea><wicri:noRegion>Oldenburg</wicri:noRegion><wicri:noRegion>Oldenburg</wicri:noRegion><wicri:noRegion>Oldenburg</wicri:noRegion></affiliation></author><author><name sortKey="Labianca, R" sort="Labianca, R" uniqKey="Labianca R" first="R" last="Labianca">R. Labianca</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Center, Ospedale Giovanni XXIII, Bergamo, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Cancer Center, Ospedale Giovanni XXIII, Bergamo</wicri:regionArea><wicri:noRegion>Bergamo</wicri:noRegion></affiliation></author><author><name sortKey="Laurent Puig, P" sort="Laurent Puig, P" uniqKey="Laurent Puig P" first="P" last="Laurent-Puig">P. Laurent-Puig</name><affiliation wicri:level="3"><nlm:affiliation>Digestive Oncology Department, European Hospital Georges Pompidou, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Digestive Oncology Department, European Hospital Georges Pompidou, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Ma, B" sort="Ma, B" uniqKey="Ma B" first="B" last="Ma">B. Ma</name><affiliation wicri:level="4"><nlm:affiliation>Department of Clinical Oncology, Prince of Wales Hospital, State Key Laboratory in Oncology in South China, Chinese University of Hong Kong, Shatin, Hong Kong.</nlm:affiliation><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Clinical Oncology, Prince of Wales Hospital, State Key Laboratory in Oncology in South China, Chinese University of Hong Kong, Shatin</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Maughan, T" sort="Maughan, T" uniqKey="Maughan T" first="T" last="Maughan">T. Maughan</name><affiliation wicri:level="4"><nlm:affiliation>CRUK/MRC Oxford Institute for Radiation Oncology, Gray Laboratories, University of Oxford, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>CRUK/MRC Oxford Institute for Radiation Oncology, Gray Laboratories, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Muro, K" sort="Muro, K" uniqKey="Muro K" first="K" last="Muro">K. Muro</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Oncology and Outpatient Treatment Center, Aichi Cancer Center Hospital, Nagoya, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Clinical Oncology and Outpatient Treatment Center, Aichi Cancer Center Hospital, Nagoya</wicri:regionArea><wicri:noRegion>Nagoya</wicri:noRegion></affiliation></author><author><name sortKey="Normanno, N" sort="Normanno, N" uniqKey="Normanno N" first="N" last="Normanno">N. Normanno</name><affiliation wicri:level="1"><nlm:affiliation>Cell Biology and Biotherapy Unit, I.N.T. Fondazione G. Pascale, Napoli, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Cell Biology and Biotherapy Unit, I.N.T. Fondazione G. Pascale, Napoli</wicri:regionArea><wicri:noRegion>Napoli</wicri:noRegion></affiliation></author><author><name sortKey="Osterlund, P" sort="Osterlund, P" uniqKey="Osterlund P" first="P" last="Österlund">P. Österlund</name><affiliation wicri:level="1"><nlm:affiliation>Helsinki University Central Hospital, Comprehensive Cancer Center, Helsinki, Finland Department of Oncology, University of Helsinki, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Helsinki University Central Hospital, Comprehensive Cancer Center, Helsinki, Finland Department of Oncology, University of Helsinki, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Oyen, W J G" sort="Oyen, W J G" uniqKey="Oyen W" first="W J G" last="Oyen">W J G. Oyen</name><affiliation wicri:level="3"><nlm:affiliation>The Institute of Cancer Research and The Royal Marsden Hospital, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Institute of Cancer Research and The Royal Marsden Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Papamichael, D" sort="Papamichael, D" uniqKey="Papamichael D" first="D" last="Papamichael">D. Papamichael</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Bank of Cyprus Oncology Centre, Nicosia, Cyprus.</nlm:affiliation><country xml:lang="fr">Chypre (pays)</country><wicri:regionArea>Department of Medical Oncology, Bank of Cyprus Oncology Centre, Nicosia</wicri:regionArea><wicri:noRegion>Nicosia</wicri:noRegion></affiliation></author><author><name sortKey="Pentheroudakis, G" sort="Pentheroudakis, G" uniqKey="Pentheroudakis G" first="G" last="Pentheroudakis">G. Pentheroudakis</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, University of Ioannina, Ioannina, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Medical Oncology, University of Ioannina, Ioannina</wicri:regionArea><wicri:noRegion>Ioannina</wicri:noRegion></affiliation></author><author><name sortKey="Pfeiffer, P" sort="Pfeiffer, P" uniqKey="Pfeiffer P" first="P" last="Pfeiffer">P. Pfeiffer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, Odense University Hospital, Odense, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Oncology, Odense University Hospital, Odense</wicri:regionArea><wicri:noRegion>Odense</wicri:noRegion></affiliation></author><author><name sortKey="Price, T J" sort="Price, T J" uniqKey="Price T" first="T J" last="Price">T J Price</name><affiliation wicri:level="1"><nlm:affiliation>Haematology and Medical Oncology Unit, Queen Elizabeth Hospital, Woodville, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Haematology and Medical Oncology Unit, Queen Elizabeth Hospital, Woodville</wicri:regionArea><wicri:noRegion>Woodville</wicri:noRegion></affiliation></author><author><name sortKey="Punt, C" sort="Punt, C" uniqKey="Punt C" first="C" last="Punt">C. Punt</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medical Oncology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Oncology, Academic Medical Centre, University of Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Ricke, J" sort="Ricke, J" uniqKey="Ricke J" first="J" last="Ricke">J. Ricke</name><affiliation wicri:level="3"><nlm:affiliation>Department of Radiology and Nuclear Medicine, University Clinic Magdeburg, Magdeburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Radiology and Nuclear Medicine, University Clinic Magdeburg, Magdeburg</wicri:regionArea><placeName><region type="land" nuts="2">Saxe-Anhalt</region><settlement type="city">Magdebourg</settlement></placeName></affiliation></author><author><name sortKey="Roth, A" sort="Roth, A" uniqKey="Roth A" first="A" last="Roth">A. Roth</name><affiliation wicri:level="1"><nlm:affiliation>Digestive Tumors Unit, Geneva University Hospitals (HUG), Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Digestive Tumors Unit, Geneva University Hospitals (HUG), Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Salazar, R" sort="Salazar, R" uniqKey="Salazar R" first="R" last="Salazar">R. Salazar</name><affiliation wicri:level="3"><nlm:affiliation>Catalan Institute of Oncology (ICO), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Catalan Institute of Oncology (ICO), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Scheithauer, W" sort="Scheithauer, W" uniqKey="Scheithauer W" first="W" last="Scheithauer">W. Scheithauer</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine I and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Internal Medicine I and Comprehensive Cancer Center, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Schmoll, H J" sort="Schmoll, H J" uniqKey="Schmoll H" first="H J" last="Schmoll">H J Schmoll</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine IV, University Clinic Halle, Martin-Luther-University Halle-Wittenberg, Halle, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine IV, University Clinic Halle, Martin-Luther-University Halle-Wittenberg, Halle</wicri:regionArea><wicri:noRegion>Halle</wicri:noRegion><wicri:noRegion>Halle</wicri:noRegion><wicri:noRegion>Halle</wicri:noRegion></affiliation></author><author><name sortKey="Tabernero, J" sort="Tabernero, J" uniqKey="Tabernero J" first="J" last="Tabernero">J. Tabernero</name><affiliation wicri:level="3"><nlm:affiliation>Medical Oncology Department, Vall d' Hebron University Hospital, Vall d'Hebron Institute of Oncology (V.H.I.O.), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Medical Oncology Department, Vall d' Hebron University Hospital, Vall d'Hebron Institute of Oncology (V.H.I.O.), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Taieb, J" sort="Taieb, J" uniqKey="Taieb J" first="J" last="Taïeb">J. Taïeb</name><affiliation wicri:level="3"><nlm:affiliation>Digestive Oncology Department, European Hospital Georges Pompidou, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Digestive Oncology Department, European Hospital Georges Pompidou, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Tejpar, S" sort="Tejpar, S" uniqKey="Tejpar S" first="S" last="Tejpar">S. Tejpar</name><affiliation wicri:level="1"><nlm:affiliation>Digestive Oncology, University Hospitals Gasthuisberg Leuven and KU Leuven, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Digestive Oncology, University Hospitals Gasthuisberg Leuven and KU Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Wasan, H" sort="Wasan, H" uniqKey="Wasan H" first="H" last="Wasan">H. Wasan</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cancer Medicine, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Cancer Medicine, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Yoshino, T" sort="Yoshino, T" uniqKey="Yoshino T" first="T" last="Yoshino">T. Yoshino</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Chiba, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Chiba</wicri:regionArea><wicri:noRegion>Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Zaanan, A" sort="Zaanan, A" uniqKey="Zaanan A" first="A" last="Zaanan">A. Zaanan</name><affiliation wicri:level="3"><nlm:affiliation>Digestive Oncology Department, European Hospital Georges Pompidou, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Digestive Oncology Department, European Hospital Georges Pompidou, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Arnold, D" sort="Arnold, D" uniqKey="Arnold D" first="D" last="Arnold">D. Arnold</name><affiliation wicri:level="1"><nlm:affiliation>Instituto CUF de Oncologia (ICO), Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Instituto CUF de Oncologia (ICO), Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author></analytic><series><title level="j">Annals of oncology : official journal of the European Society for Medical Oncology</title><idno type="eISSN">1569-8041</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Colorectal cancer (CRC) is one of the most common malignancies in Western countries. Over the last 20 years, and the last decade in particular, the clinical outcome for patients with metastatic CRC (mCRC) has improved greatly due not only to an increase in the number of patients being referred for and undergoing surgical resection of their localised metastatic disease but also to a more strategic approach to the delivery of systemic therapy and an expansion in the use of ablative techniques. This reflects the increase in the number of patients that are being managed within a multidisciplinary team environment and specialist cancer centres, and the emergence over the same time period not only of improved imaging techniques but also prognostic and predictive molecular markers. Treatment decisions for patients with mCRC must be evidence-based. Thus, these ESMO consensus guidelines have been developed based on the current available evidence to provide a series of evidence-based recommendations to assist in the treatment and management of patients with mCRC in this rapidly evolving treatment setting.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">27380959</PMID><DateCreated><Year>2016</Year><Month>07</Month><Day>26</Day></DateCreated><DateRevised><Year>2016</Year><Month>10</Month><Day>17</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1569-8041</ISSN><JournalIssue CitedMedium="Internet"><Volume>27</Volume><Issue>8</Issue><PubDate><Year>2016</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Annals of oncology : official journal of the European Society for Medical Oncology</Title><ISOAbbreviation>Ann. Oncol.</ISOAbbreviation></Journal><ArticleTitle>ESMO consensus guidelines for the management of patients with metastatic colorectal cancer.</ArticleTitle><Pagination><MedlinePgn>1386-422</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/annonc/mdw235</ELocationID><Abstract><AbstractText>Colorectal cancer (CRC) is one of the most common malignancies in Western countries. Over the last 20 years, and the last decade in particular, the clinical outcome for patients with metastatic CRC (mCRC) has improved greatly due not only to an increase in the number of patients being referred for and undergoing surgical resection of their localised metastatic disease but also to a more strategic approach to the delivery of systemic therapy and an expansion in the use of ablative techniques. This reflects the increase in the number of patients that are being managed within a multidisciplinary team environment and specialist cancer centres, and the emergence over the same time period not only of improved imaging techniques but also prognostic and predictive molecular markers. Treatment decisions for patients with mCRC must be evidence-based. Thus, these ESMO consensus guidelines have been developed based on the current available evidence to provide a series of evidence-based recommendations to assist in the treatment and management of patients with mCRC in this rapidly evolving treatment setting.</AbstractText><CopyrightInformation>© The Author 2016. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Van Cutsem</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Digestive Oncology, University Hospitals Gasthuisberg Leuven and KU Leuven, Leuven, Belgium clinicalguidelines@esmo.org.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cervantes</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Medical Oncology Department, INCLIVA University of Valencia, Valencia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Adam</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Hepato-Biliary Centre, Paul Brousse Hospital, Villejuif, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sobrero</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Medical Oncology, IRCCS San Martino Hospital, Genova, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Van Krieken</LastName><ForeName>J H</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Research Institute for Oncology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aderka</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Division of Oncology, Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aranda Aguilar</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Medical Oncology Department, University Hospital Reina Sofia, Cordoba, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bardelli</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>School of Medicine, University of Turin, Turin, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Benson</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Division of Hematology/Oncology, Northwestern Medical Group, Chicago, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bodoky</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Oncology, St László Hospital, Budapest, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ciardiello</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Division of Medical Oncology, Seconda Università di Napoli, Naples, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>D'Hoore</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Abdominal Surgery, University Hospitals Gasthuisberg Leuven and KU Leuven, Leuven, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Diaz-Rubio</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Medical Oncology Department, Hospital Clínico San Carlos, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Douillard</LastName><ForeName>J-Y</ForeName><Initials>JY</Initials><AffiliationInfo><Affiliation>Medical Oncology, Institut de Cancérologie de l'Ouest (ICO), St Herblain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ducreux</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medical Oncology, Gustave Roussy, Université Paris-Saclay, Villejuif, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Falcone</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Medical Oncology, University of Pisa, Pisa, Italy Division of Medical Oncology, Department of Oncology, University Hospital 'S. Chiara', Istituto Toscano Tumori, Pisa, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grothey</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Division of Medical Oncology, Mayo Clinic, Rochester, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gruenberger</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Surgery I, Rudolfstiftung Hospital, Vienna, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haustermans</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Radiation Oncology, University Hospitals Gasthuisberg and KU Leuven, Leuven, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Heinemann</LastName><ForeName>V</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Comprehensive Cancer Center, University Clinic Munich, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hoff</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Instituto do Câncer do Estado de São Paulo, University of São Paulo, São Paulo, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Köhne</LastName><ForeName>C-H</ForeName><Initials>CH</Initials><AffiliationInfo><Affiliation>Northwest German Cancer Center, University Campus Klinikum Oldenburg, Oldenburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Labianca</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Cancer Center, Ospedale Giovanni XXIII, Bergamo, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Laurent-Puig</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Digestive Oncology Department, European Hospital Georges Pompidou, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ma</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Clinical Oncology, Prince of Wales Hospital, State Key Laboratory in Oncology in South China, Chinese University of Hong Kong, Shatin, Hong Kong.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maughan</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>CRUK/MRC Oxford Institute for Radiation Oncology, Gray Laboratories, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Muro</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Clinical Oncology and Outpatient Treatment Center, Aichi Cancer Center Hospital, Nagoya, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Normanno</LastName><ForeName>N</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Cell Biology and Biotherapy Unit, I.N.T. Fondazione G. Pascale, Napoli, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Österlund</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Helsinki University Central Hospital, Comprehensive Cancer Center, Helsinki, Finland Department of Oncology, University of Helsinki, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oyen</LastName><ForeName>W J G</ForeName><Initials>WJ</Initials><AffiliationInfo><Affiliation>The Institute of Cancer Research and The Royal Marsden Hospital, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Papamichael</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Medical Oncology, Bank of Cyprus Oncology Centre, Nicosia, Cyprus.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pentheroudakis</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Medical Oncology, University of Ioannina, Ioannina, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pfeiffer</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Oncology, Odense University Hospital, Odense, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Price</LastName><ForeName>T J</ForeName><Initials>TJ</Initials><AffiliationInfo><Affiliation>Haematology and Medical Oncology Unit, Queen Elizabeth Hospital, Woodville, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Punt</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Medical Oncology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ricke</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Radiology and Nuclear Medicine, University Clinic Magdeburg, Magdeburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Roth</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Digestive Tumors Unit, Geneva University Hospitals (HUG), Geneva, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Salazar</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Catalan Institute of Oncology (ICO), Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Scheithauer</LastName><ForeName>W</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine I and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schmoll</LastName><ForeName>H J</ForeName><Initials>HJ</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine IV, University Clinic Halle, Martin-Luther-University Halle-Wittenberg, Halle, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tabernero</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Medical Oncology Department, Vall d' Hebron University Hospital, Vall d'Hebron Institute of Oncology (V.H.I.O.), Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Taïeb</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Digestive Oncology Department, European Hospital Georges Pompidou, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tejpar</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Digestive Oncology, University Hospitals Gasthuisberg Leuven and KU Leuven, Leuven, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wasan</LastName><ForeName>H</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Cancer Medicine, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yoshino</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Chiba, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zaanan</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Digestive Oncology Department, European Hospital Georges Pompidou, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arnold</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Instituto CUF de Oncologia (ICO), Lisbon, Portugal.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>07</Month><Day>05</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Ann Oncol</MedlineTA><NlmUniqueID>9007735</NlmUniqueID><ISSNLinking>0923-7534</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">ESMO</Keyword><Keyword MajorTopicYN="N">clinical practice guidelines</Keyword><Keyword MajorTopicYN="N">colorectal cancer</Keyword><Keyword MajorTopicYN="N">consensus</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>03</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>05</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>7</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>7</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>7</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27380959</ArticleId><ArticleId IdType="pii">mdw235</ArticleId><ArticleId IdType="doi">10.1093/annonc/mdw235</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Autriche</li><li>Belgique</li><li>Brésil</li><li>Chypre (pays)</li><li>Danemark</li><li>Espagne</li><li>Finlande</li><li>France</li><li>Grèce</li><li>Hong Kong</li><li>Hongrie</li><li>Israël</li><li>Italie</li><li>Japon</li><li>Pays-Bas</li><li>Portugal</li><li>Royaume-Uni</li><li>Suisse</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Bavière</li><li>Catalogne</li><li>Communauté de Madrid</li><li>District de Haute-Bavière</li><li>Grand Londres</li><li>Gueldre</li><li>Hollande-Septentrionale</li><li>Hongrie centrale</li><li>Illinois</li><li>Oxfordshire</li><li>Piémont</li><li>Saxe-Anhalt</li><li>Toscane</li><li>Vienne (Autriche)</li><li>État de São Paulo</li><li>Île-de-France</li></region><settlement><li>Amsterdam</li><li>Barcelone</li><li>Budapest</li><li>Chicago</li><li>Londres</li><li>Madrid</li><li>Magdebourg</li><li>Munich</li><li>Nimègue</li><li>Oxford</li><li>Paris</li><li>Pise</li><li>Sha Tin</li><li>São Paulo</li><li>Turin</li><li>Vienne (Autriche)</li></settlement><orgName><li>Université chinoise de Hong Kong</li><li>Université d'Amsterdam</li><li>Université d'Oxford</li><li>Université de Pise</li><li>Université de São Paulo</li></orgName></list><tree><noCountry><name sortKey="Douillard, J Y" sort="Douillard, J Y" uniqKey="Douillard J" first="J-Y" last="Douillard">J-Y Douillard</name><name sortKey="Van Cutsem, E" sort="Van Cutsem, E" uniqKey="Van Cutsem E" first="E" last="Van Cutsem">E. Van Cutsem</name></noCountry><country name="Espagne"><noRegion><name sortKey="Cervantes, A" sort="Cervantes, A" uniqKey="Cervantes A" first="A" last="Cervantes">A. Cervantes</name></noRegion><name sortKey="Aranda Aguilar, E" sort="Aranda Aguilar, E" uniqKey="Aranda Aguilar E" first="E" last="Aranda Aguilar">E. Aranda Aguilar</name><name sortKey="Diaz Rubio, E" sort="Diaz Rubio, E" uniqKey="Diaz Rubio E" first="E" last="Diaz-Rubio">E. Diaz-Rubio</name><name sortKey="Salazar, R" sort="Salazar, R" uniqKey="Salazar R" first="R" last="Salazar">R. Salazar</name><name sortKey="Tabernero, J" sort="Tabernero, J" uniqKey="Tabernero J" first="J" last="Tabernero">J. Tabernero</name></country><country name="France"><noRegion><name sortKey="Adam, R" sort="Adam, R" uniqKey="Adam R" first="R" last="Adam">R. Adam</name></noRegion><name sortKey="Ducreux, M" sort="Ducreux, M" uniqKey="Ducreux M" first="M" last="Ducreux">M. 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