Efficacy of a specific polyclonal equine F(ab')2 against avian influenza (H5N1) in ferrets: synergy with oseltamivir.
Identifieur interne : 001F63 ( PubMed/Checkpoint ); précédent : 001F62; suivant : 001F64Efficacy of a specific polyclonal equine F(ab')2 against avian influenza (H5N1) in ferrets: synergy with oseltamivir.
Auteurs : Cécile H. Herbreteau [France] ; Mélanie Denizot [France] ; Suzanne Lowther [Australie] ; Sarah Riddell [Australie] ; Leah Frazer [Australie] ; Jessica Haining [Australie] ; Rachel Arkinstall [Australie] ; Jean Payne [Australie] ; Jenni Harper [Australie] ; Dayna Johnson [Australie] ; Anaïs Pasquier [France] ; Deborah Middleton [Australie] ; Jean-François Saluzzo [France]Source :
- Immunotherapy [ 1750-7448 ] ; 2016.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (usage thérapeutique), Antiviraux (usage thérapeutique), Association de médicaments, Charge virale, Equus caballus, Fragments Fab d'immunoglobuline (usage thérapeutique), Furets, Immunisation passive (), Infections à Orthomyxoviridae (), Infections à Orthomyxoviridae (immunologie), Modèles animaux de maladie humaine, Médicament orphelin, Oséltamivir (usage thérapeutique), Sous-type H5N1 du virus de la grippe A (physiologie), Synergie des médicaments.
- MESH :
- immunologie : Infections à Orthomyxoviridae.
- physiologie : Sous-type H5N1 du virus de la grippe A.
- usage thérapeutique : Anticorps antiviraux, Antiviraux, Fragments Fab d'immunoglobuline, Oséltamivir.
- Animaux, Association de médicaments, Charge virale, Equus caballus, Furets, Immunisation passive, Infections à Orthomyxoviridae, Modèles animaux de maladie humaine, Médicament orphelin, Synergie des médicaments.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral (therapeutic use), Antiviral Agents (therapeutic use), Disease Models, Animal, Drug Synergism, Drug Therapy, Combination, Ferrets, Horses, Immunization, Passive (methods), Immunoglobulin Fab Fragments (therapeutic use), Influenza A Virus, H5N1 Subtype (physiology), Orphan Drug Production, Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (therapy), Oseltamivir (therapeutic use), Viral Load.
- MESH :
- chemical , therapeutic use : Antibodies, Viral, Antiviral Agents, Immunoglobulin Fab Fragments, Oseltamivir.
- immunology : Orthomyxoviridae Infections.
- methods : Immunization, Passive.
- physiology : Influenza A Virus, H5N1 Subtype.
- therapy : Orthomyxoviridae Infections.
- Animals, Disease Models, Animal, Drug Synergism, Drug Therapy, Combination, Ferrets, Horses, Orphan Drug Production, Viral Load.
Abstract
Current therapies against avian influenza (H5N1) provide limited clinical benefit. FBF-001 is a highly purified equine polyclonal immunoglobulin fragment against H5N1.
DOI: 10.2217/imt-2016-0062
PubMed: 27380317
Affiliations:
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pubmed:27380317Le document en format XML
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<term>Antibodies, Viral (therapeutic use)</term>
<term>Antiviral Agents (therapeutic use)</term>
<term>Disease Models, Animal</term>
<term>Drug Synergism</term>
<term>Drug Therapy, Combination</term>
<term>Ferrets</term>
<term>Horses</term>
<term>Immunization, Passive (methods)</term>
<term>Immunoglobulin Fab Fragments (therapeutic use)</term>
<term>Influenza A Virus, H5N1 Subtype (physiology)</term>
<term>Orphan Drug Production</term>
<term>Orthomyxoviridae Infections (immunology)</term>
<term>Orthomyxoviridae Infections (therapy)</term>
<term>Oseltamivir (therapeutic use)</term>
<term>Viral Load</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Anticorps antiviraux (usage thérapeutique)</term>
<term>Antiviraux (usage thérapeutique)</term>
<term>Association de médicaments</term>
<term>Charge virale</term>
<term>Equus caballus</term>
<term>Fragments Fab d'immunoglobuline (usage thérapeutique)</term>
<term>Furets</term>
<term>Immunisation passive ()</term>
<term>Infections à Orthomyxoviridae ()</term>
<term>Infections à Orthomyxoviridae (immunologie)</term>
<term>Modèles animaux de maladie humaine</term>
<term>Médicament orphelin</term>
<term>Oséltamivir (usage thérapeutique)</term>
<term>Sous-type H5N1 du virus de la grippe A (physiologie)</term>
<term>Synergie des médicaments</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antibodies, Viral</term>
<term>Antiviral Agents</term>
<term>Immunoglobulin Fab Fragments</term>
<term>Oseltamivir</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Infections à Orthomyxoviridae</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Orthomyxoviridae Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Immunization, Passive</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Sous-type H5N1 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Influenza A Virus, H5N1 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Orthomyxoviridae Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anticorps antiviraux</term>
<term>Antiviraux</term>
<term>Fragments Fab d'immunoglobuline</term>
<term>Oséltamivir</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Disease Models, Animal</term>
<term>Drug Synergism</term>
<term>Drug Therapy, Combination</term>
<term>Ferrets</term>
<term>Horses</term>
<term>Orphan Drug Production</term>
<term>Viral Load</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Association de médicaments</term>
<term>Charge virale</term>
<term>Equus caballus</term>
<term>Furets</term>
<term>Immunisation passive</term>
<term>Infections à Orthomyxoviridae</term>
<term>Modèles animaux de maladie humaine</term>
<term>Médicament orphelin</term>
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<front><div type="abstract" xml:lang="en">Current therapies against avian influenza (H5N1) provide limited clinical benefit. FBF-001 is a highly purified equine polyclonal immunoglobulin fragment against H5N1.</div>
</front>
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<Month>08</Month>
<Day>03</Day>
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<Month>07</Month>
<Day>10</Day>
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<Title>Immunotherapy</Title>
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</Journal>
<ArticleTitle>Efficacy of a specific polyclonal equine F(ab')2 against avian influenza (H5N1) in ferrets: synergy with oseltamivir.</ArticleTitle>
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<ELocationID EIdType="doi" ValidYN="Y">10.2217/imt-2016-0062</ELocationID>
<Abstract><AbstractText Label="AIM" NlmCategory="OBJECTIVE">Current therapies against avian influenza (H5N1) provide limited clinical benefit. FBF-001 is a highly purified equine polyclonal immunoglobulin fragment against H5N1.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Using a ferret model of severe acute H5N1 infection, we assessed FBF-001 when administered on the same day or 1 day after viral challenge, in comparison with oseltamivir therapy.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Untreated animals died 2-3 days after challenge. FBF-001 prevented most severe illness and reduced nasal viral load, with best efficacy when administered on the day of viral challenge. Oseltamivir and FBF-001 had synergistic impact on survival.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">FBF-001 prevented severe consequences of lethal H5N1 challenge in ferrets by controlling viral replication, an effect synergistic to oseltamivir. FBF-001 has recently been granted EMA orphan drug status.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Herbreteau</LastName>
<ForeName>Cécile H</ForeName>
<Initials>CH</Initials>
<AffiliationInfo><Affiliation>Fab'entech, 24, rue Jean Baldassini - Bâtiment B, 69007 Lyon, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Denizot</LastName>
<ForeName>Mélanie</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Fab'entech, 24, rue Jean Baldassini - Bâtiment B, 69007 Lyon, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lowther</LastName>
<ForeName>Suzanne</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>CSIRO Australian Animal Health Laboratory, Geelong, Victoria, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Riddell</LastName>
<ForeName>Sarah</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>CSIRO Australian Animal Health Laboratory, Geelong, Victoria, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Frazer</LastName>
<ForeName>Leah</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>CSIRO Australian Animal Health Laboratory, Geelong, Victoria, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Haining</LastName>
<ForeName>Jessica</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>CSIRO Australian Animal Health Laboratory, Geelong, Victoria, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Arkinstall</LastName>
<ForeName>Rachel</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>CSIRO Australian Animal Health Laboratory, Geelong, Victoria, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Payne</LastName>
<ForeName>Jean</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>CSIRO Australian Animal Health Laboratory, Geelong, Victoria, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Harper</LastName>
<ForeName>Jenni</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>CSIRO Australian Animal Health Laboratory, Geelong, Victoria, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Johnson</LastName>
<ForeName>Dayna</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>CSIRO Australian Animal Health Laboratory, Geelong, Victoria, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pasquier</LastName>
<ForeName>Anaïs</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Fab'entech, 24, rue Jean Baldassini - Bâtiment B, 69007 Lyon, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Middleton</LastName>
<ForeName>Deborah</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>CSIRO Australian Animal Health Laboratory, Geelong, Victoria, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Saluzzo</LastName>
<ForeName>Jean-François</ForeName>
<Initials>JF</Initials>
<AffiliationInfo><Affiliation>Fab'entech, 24, rue Jean Baldassini - Bâtiment B, 69007 Lyon, France.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>07</Month>
<Day>05</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Immunotherapy</MedlineTA>
<NlmUniqueID>101485158</NlmUniqueID>
<ISSNLinking>1750-743X</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D007140">Immunoglobulin Fab Fragments</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>20O93L6F9H</RegistryNumber>
<NameOfSubstance UI="D053139">Oseltamivir</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004357" MajorTopicYN="N">Drug Synergism</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004359" MajorTopicYN="N">Drug Therapy, Combination</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005289" MajorTopicYN="N">Ferrets</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006736" MajorTopicYN="N">Horses</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007116" MajorTopicYN="N">Immunization, Passive</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007140" MajorTopicYN="N">Immunoglobulin Fab Fragments</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053124" MajorTopicYN="N">Influenza A Virus, H5N1 Subtype</DescriptorName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009965" MajorTopicYN="N">Orphan Drug Production</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009976" MajorTopicYN="N">Orthomyxoviridae Infections</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053139" MajorTopicYN="N">Oseltamivir</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019562" MajorTopicYN="N">Viral Load</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">A/H5N1</Keyword>
<Keyword MajorTopicYN="N">F(ab')2</Keyword>
<Keyword MajorTopicYN="N">avian influenza</Keyword>
<Keyword MajorTopicYN="N">ferret</Keyword>
<Keyword MajorTopicYN="N">immunoglobulin</Keyword>
<Keyword MajorTopicYN="N">oseltamivir</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2016</Year>
<Month>7</Month>
<Day>6</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2016</Year>
<Month>7</Month>
<Day>6</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2017</Year>
<Month>7</Month>
<Day>14</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">27380317</ArticleId>
<ArticleId IdType="doi">10.2217/imt-2016-0062</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Australie</li>
<li>France</li>
</country>
<region><li>Auvergne-Rhône-Alpes</li>
<li>Rhône-Alpes</li>
</region>
<settlement><li>Lyon</li>
</settlement>
</list>
<tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Herbreteau, Cecile H" sort="Herbreteau, Cecile H" uniqKey="Herbreteau C" first="Cécile H" last="Herbreteau">Cécile H. Herbreteau</name>
</region>
<name sortKey="Denizot, Melanie" sort="Denizot, Melanie" uniqKey="Denizot M" first="Mélanie" last="Denizot">Mélanie Denizot</name>
<name sortKey="Pasquier, Anais" sort="Pasquier, Anais" uniqKey="Pasquier A" first="Anaïs" last="Pasquier">Anaïs Pasquier</name>
<name sortKey="Saluzzo, Jean Francois" sort="Saluzzo, Jean Francois" uniqKey="Saluzzo J" first="Jean-François" last="Saluzzo">Jean-François Saluzzo</name>
</country>
<country name="Australie"><noRegion><name sortKey="Lowther, Suzanne" sort="Lowther, Suzanne" uniqKey="Lowther S" first="Suzanne" last="Lowther">Suzanne Lowther</name>
</noRegion>
<name sortKey="Arkinstall, Rachel" sort="Arkinstall, Rachel" uniqKey="Arkinstall R" first="Rachel" last="Arkinstall">Rachel Arkinstall</name>
<name sortKey="Frazer, Leah" sort="Frazer, Leah" uniqKey="Frazer L" first="Leah" last="Frazer">Leah Frazer</name>
<name sortKey="Haining, Jessica" sort="Haining, Jessica" uniqKey="Haining J" first="Jessica" last="Haining">Jessica Haining</name>
<name sortKey="Harper, Jenni" sort="Harper, Jenni" uniqKey="Harper J" first="Jenni" last="Harper">Jenni Harper</name>
<name sortKey="Johnson, Dayna" sort="Johnson, Dayna" uniqKey="Johnson D" first="Dayna" last="Johnson">Dayna Johnson</name>
<name sortKey="Middleton, Deborah" sort="Middleton, Deborah" uniqKey="Middleton D" first="Deborah" last="Middleton">Deborah Middleton</name>
<name sortKey="Payne, Jean" sort="Payne, Jean" uniqKey="Payne J" first="Jean" last="Payne">Jean Payne</name>
<name sortKey="Riddell, Sarah" sort="Riddell, Sarah" uniqKey="Riddell S" first="Sarah" last="Riddell">Sarah Riddell</name>
</country>
</tree>
</affiliations>
</record>
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