Efficacy of a specific polyclonal equine F(ab')2 against avian influenza (H5N1) in ferrets: synergy with oseltamivir.
Identifieur interne : 001F63 ( PubMed/Checkpoint ); précédent : 001F62; suivant : 001F64Efficacy of a specific polyclonal equine F(ab')2 against avian influenza (H5N1) in ferrets: synergy with oseltamivir.
Auteurs : Cécile H. Herbreteau [France] ; Mélanie Denizot [France] ; Suzanne Lowther [Australie] ; Sarah Riddell [Australie] ; Leah Frazer [Australie] ; Jessica Haining [Australie] ; Rachel Arkinstall [Australie] ; Jean Payne [Australie] ; Jenni Harper [Australie] ; Dayna Johnson [Australie] ; Anaïs Pasquier [France] ; Deborah Middleton [Australie] ; Jean-François Saluzzo [France]Source :
- Immunotherapy [ 1750-7448 ] ; 2016.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (usage thérapeutique), Antiviraux (usage thérapeutique), Association de médicaments, Charge virale, Equus caballus, Fragments Fab d'immunoglobuline (usage thérapeutique), Furets, Immunisation passive (), Infections à Orthomyxoviridae (), Infections à Orthomyxoviridae (immunologie), Modèles animaux de maladie humaine, Médicament orphelin, Oséltamivir (usage thérapeutique), Sous-type H5N1 du virus de la grippe A (physiologie), Synergie des médicaments.
- MESH :
- immunologie : Infections à Orthomyxoviridae.
- physiologie : Sous-type H5N1 du virus de la grippe A.
- usage thérapeutique : Anticorps antiviraux, Antiviraux, Fragments Fab d'immunoglobuline, Oséltamivir.
- Animaux, Association de médicaments, Charge virale, Equus caballus, Furets, Immunisation passive, Infections à Orthomyxoviridae, Modèles animaux de maladie humaine, Médicament orphelin, Synergie des médicaments.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral (therapeutic use), Antiviral Agents (therapeutic use), Disease Models, Animal, Drug Synergism, Drug Therapy, Combination, Ferrets, Horses, Immunization, Passive (methods), Immunoglobulin Fab Fragments (therapeutic use), Influenza A Virus, H5N1 Subtype (physiology), Orphan Drug Production, Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (therapy), Oseltamivir (therapeutic use), Viral Load.
- MESH :
- chemical , therapeutic use : Antibodies, Viral, Antiviral Agents, Immunoglobulin Fab Fragments, Oseltamivir.
- immunology : Orthomyxoviridae Infections.
- methods : Immunization, Passive.
- physiology : Influenza A Virus, H5N1 Subtype.
- therapy : Orthomyxoviridae Infections.
- Animals, Disease Models, Animal, Drug Synergism, Drug Therapy, Combination, Ferrets, Horses, Orphan Drug Production, Viral Load.
Abstract
Current therapies against avian influenza (H5N1) provide limited clinical benefit. FBF-001 is a highly purified equine polyclonal immunoglobulin fragment against H5N1.
DOI: 10.2217/imt-2016-0062
PubMed: 27380317
Affiliations:
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Herbreteau</name><affiliation wicri:level="3"><nlm:affiliation>Fab'entech, 24, rue Jean Baldassini - Bâtiment B, 69007 Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Fab'entech, 24, rue Jean Baldassini - Bâtiment B, 69007 Lyon</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Denizot, Melanie" sort="Denizot, Melanie" uniqKey="Denizot M" first="Mélanie" last="Denizot">Mélanie Denizot</name><affiliation wicri:level="3"><nlm:affiliation>Fab'entech, 24, rue Jean Baldassini - Bâtiment B, 69007 Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Fab'entech, 24, rue Jean Baldassini - Bâtiment B, 69007 Lyon</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Lowther, Suzanne" sort="Lowther, Suzanne" uniqKey="Lowther S" first="Suzanne" last="Lowther">Suzanne Lowther</name><affiliation wicri:level="1"><nlm:affiliation>CSIRO Australian Animal Health Laboratory, Geelong, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>CSIRO Australian Animal Health Laboratory, Geelong, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Riddell, Sarah" sort="Riddell, Sarah" uniqKey="Riddell S" first="Sarah" last="Riddell">Sarah Riddell</name><affiliation wicri:level="1"><nlm:affiliation>CSIRO Australian Animal Health Laboratory, Geelong, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>CSIRO Australian Animal Health Laboratory, Geelong, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Frazer, Leah" sort="Frazer, Leah" uniqKey="Frazer L" first="Leah" last="Frazer">Leah Frazer</name><affiliation wicri:level="1"><nlm:affiliation>CSIRO Australian Animal Health Laboratory, Geelong, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>CSIRO Australian Animal Health Laboratory, Geelong, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Haining, Jessica" sort="Haining, Jessica" uniqKey="Haining J" first="Jessica" last="Haining">Jessica Haining</name><affiliation wicri:level="1"><nlm:affiliation>CSIRO Australian Animal Health Laboratory, Geelong, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>CSIRO Australian Animal Health Laboratory, Geelong, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Arkinstall, Rachel" sort="Arkinstall, Rachel" uniqKey="Arkinstall R" first="Rachel" last="Arkinstall">Rachel Arkinstall</name><affiliation wicri:level="1"><nlm:affiliation>CSIRO Australian Animal Health Laboratory, Geelong, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>CSIRO Australian Animal Health Laboratory, Geelong, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Payne, Jean" sort="Payne, Jean" uniqKey="Payne J" first="Jean" last="Payne">Jean Payne</name><affiliation wicri:level="1"><nlm:affiliation>CSIRO Australian Animal Health Laboratory, Geelong, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>CSIRO Australian Animal Health Laboratory, Geelong, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Harper, Jenni" sort="Harper, Jenni" uniqKey="Harper J" first="Jenni" last="Harper">Jenni Harper</name><affiliation wicri:level="1"><nlm:affiliation>CSIRO Australian Animal Health Laboratory, Geelong, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>CSIRO Australian Animal Health Laboratory, Geelong, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Johnson, Dayna" sort="Johnson, Dayna" uniqKey="Johnson D" first="Dayna" last="Johnson">Dayna Johnson</name><affiliation wicri:level="1"><nlm:affiliation>CSIRO Australian Animal Health Laboratory, Geelong, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>CSIRO Australian Animal Health Laboratory, Geelong, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Pasquier, Anais" sort="Pasquier, Anais" uniqKey="Pasquier A" first="Anaïs" last="Pasquier">Anaïs Pasquier</name><affiliation wicri:level="1"><nlm:affiliation>Fab'entech, 24, rue Jean Baldassini - Bâtiment B, 69007 Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Fab'entech, 24, rue Jean Baldassini - Bâtiment B, 69007 Lyon</wicri:regionArea><wicri:noRegion>69007 Lyon</wicri:noRegion><placeName><settlement type="city">Lyon</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Middleton, Deborah" sort="Middleton, Deborah" uniqKey="Middleton D" first="Deborah" last="Middleton">Deborah Middleton</name><affiliation wicri:level="1"><nlm:affiliation>CSIRO Australian Animal Health Laboratory, Geelong, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>CSIRO Australian Animal Health Laboratory, Geelong, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Saluzzo, Jean Francois" sort="Saluzzo, Jean Francois" uniqKey="Saluzzo J" first="Jean-François" last="Saluzzo">Jean-François Saluzzo</name><affiliation wicri:level="1"><nlm:affiliation>Fab'entech, 24, rue Jean Baldassini - Bâtiment B, 69007 Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Fab'entech, 24, rue Jean Baldassini - Bâtiment B, 69007 Lyon</wicri:regionArea><wicri:noRegion>69007 Lyon</wicri:noRegion><placeName><settlement type="city">Lyon</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author></analytic><series><title level="j">Immunotherapy</title><idno type="eISSN">1750-7448</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Viral (therapeutic use)</term><term>Antiviral Agents (therapeutic use)</term><term>Disease Models, Animal</term><term>Drug Synergism</term><term>Drug Therapy, Combination</term><term>Ferrets</term><term>Horses</term><term>Immunization, Passive (methods)</term><term>Immunoglobulin Fab Fragments (therapeutic use)</term><term>Influenza A Virus, H5N1 Subtype (physiology)</term><term>Orphan Drug Production</term><term>Orthomyxoviridae Infections (immunology)</term><term>Orthomyxoviridae Infections (therapy)</term><term>Oseltamivir (therapeutic use)</term><term>Viral Load</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux (usage thérapeutique)</term><term>Antiviraux (usage thérapeutique)</term><term>Association de médicaments</term><term>Charge virale</term><term>Equus caballus</term><term>Fragments Fab d'immunoglobuline (usage thérapeutique)</term><term>Furets</term><term>Immunisation passive ()</term><term>Infections à Orthomyxoviridae ()</term><term>Infections à Orthomyxoviridae (immunologie)</term><term>Modèles animaux de maladie humaine</term><term>Médicament orphelin</term><term>Oséltamivir (usage thérapeutique)</term><term>Sous-type H5N1 du virus de la grippe A (physiologie)</term><term>Synergie des médicaments</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antibodies, Viral</term><term>Antiviral Agents</term><term>Immunoglobulin Fab Fragments</term><term>Oseltamivir</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Infections à Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Immunization, Passive</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Sous-type H5N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Influenza A Virus, H5N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anticorps antiviraux</term><term>Antiviraux</term><term>Fragments Fab d'immunoglobuline</term><term>Oséltamivir</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Drug Synergism</term><term>Drug Therapy, Combination</term><term>Ferrets</term><term>Horses</term><term>Orphan Drug Production</term><term>Viral Load</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Association de médicaments</term><term>Charge virale</term><term>Equus caballus</term><term>Furets</term><term>Immunisation passive</term><term>Infections à Orthomyxoviridae</term><term>Modèles animaux de maladie humaine</term><term>Médicament orphelin</term><term>Synergie des médicaments</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Current therapies against avian influenza (H5N1) provide limited clinical benefit. FBF-001 is a highly purified equine polyclonal immunoglobulin fragment against H5N1.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27380317</PMID><DateCreated><Year>2016</Year><Month>08</Month><Day>03</Day></DateCreated><DateCompleted><Year>2017</Year><Month>07</Month><Day>10</Day></DateCompleted><DateRevised><Year>2017</Year><Month>07</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1750-7448</ISSN><JournalIssue CitedMedium="Internet"><Volume>8</Volume><Issue>9</Issue><PubDate><Year>2016</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Immunotherapy</Title><ISOAbbreviation>Immunotherapy</ISOAbbreviation></Journal><ArticleTitle>Efficacy of a specific polyclonal equine F(ab')2 against avian influenza (H5N1) in ferrets: synergy with oseltamivir.</ArticleTitle><Pagination><MedlinePgn>1021-32</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.2217/imt-2016-0062</ELocationID><Abstract><AbstractText Label="AIM" NlmCategory="OBJECTIVE">Current therapies against avian influenza (H5N1) provide limited clinical benefit. FBF-001 is a highly purified equine polyclonal immunoglobulin fragment against H5N1.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Using a ferret model of severe acute H5N1 infection, we assessed FBF-001 when administered on the same day or 1 day after viral challenge, in comparison with oseltamivir therapy.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Untreated animals died 2-3 days after challenge. FBF-001 prevented most severe illness and reduced nasal viral load, with best efficacy when administered on the day of viral challenge. Oseltamivir and FBF-001 had synergistic impact on survival.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">FBF-001 prevented severe consequences of lethal H5N1 challenge in ferrets by controlling viral replication, an effect synergistic to oseltamivir. FBF-001 has recently been granted EMA orphan drug status.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Herbreteau</LastName><ForeName>Cécile H</ForeName><Initials>CH</Initials><AffiliationInfo><Affiliation>Fab'entech, 24, rue Jean Baldassini - Bâtiment B, 69007 Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Denizot</LastName><ForeName>Mélanie</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Fab'entech, 24, rue Jean Baldassini - Bâtiment B, 69007 Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lowther</LastName><ForeName>Suzanne</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>CSIRO Australian Animal Health Laboratory, Geelong, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Riddell</LastName><ForeName>Sarah</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>CSIRO Australian Animal Health Laboratory, Geelong, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Frazer</LastName><ForeName>Leah</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>CSIRO Australian Animal Health Laboratory, Geelong, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haining</LastName><ForeName>Jessica</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>CSIRO Australian Animal Health Laboratory, Geelong, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arkinstall</LastName><ForeName>Rachel</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>CSIRO Australian Animal Health Laboratory, Geelong, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Payne</LastName><ForeName>Jean</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>CSIRO Australian Animal Health Laboratory, Geelong, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Harper</LastName><ForeName>Jenni</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>CSIRO Australian Animal Health Laboratory, Geelong, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Johnson</LastName><ForeName>Dayna</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>CSIRO Australian Animal Health Laboratory, Geelong, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pasquier</LastName><ForeName>Anaïs</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Fab'entech, 24, rue Jean Baldassini - Bâtiment B, 69007 Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Middleton</LastName><ForeName>Deborah</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>CSIRO Australian Animal Health Laboratory, Geelong, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Saluzzo</LastName><ForeName>Jean-François</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>Fab'entech, 24, rue Jean Baldassini - Bâtiment B, 69007 Lyon, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>07</Month><Day>05</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Immunotherapy</MedlineTA><NlmUniqueID>101485158</NlmUniqueID><ISSNLinking>1750-743X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007140">Immunoglobulin Fab Fragments</NameOfSubstance></Chemical><Chemical><RegistryNumber>20O93L6F9H</RegistryNumber><NameOfSubstance UI="D053139">Oseltamivir</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004357" MajorTopicYN="N">Drug Synergism</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004359" MajorTopicYN="N">Drug Therapy, Combination</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005289" MajorTopicYN="N">Ferrets</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006736" MajorTopicYN="N">Horses</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007116" MajorTopicYN="N">Immunization, Passive</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007140" MajorTopicYN="N">Immunoglobulin Fab Fragments</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053124" MajorTopicYN="N">Influenza A Virus, H5N1 Subtype</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009965" MajorTopicYN="N">Orphan Drug Production</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009976" MajorTopicYN="N">Orthomyxoviridae Infections</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053139" MajorTopicYN="N">Oseltamivir</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019562" MajorTopicYN="N">Viral Load</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">A/H5N1</Keyword><Keyword MajorTopicYN="N">F(ab')2</Keyword><Keyword MajorTopicYN="N">avian influenza</Keyword><Keyword MajorTopicYN="N">ferret</Keyword><Keyword MajorTopicYN="N">immunoglobulin</Keyword><Keyword MajorTopicYN="N">oseltamivir</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>7</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>7</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>7</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27380317</ArticleId><ArticleId IdType="doi">10.2217/imt-2016-0062</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region><settlement><li>Lyon</li></settlement></list><tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Herbreteau, Cecile H" sort="Herbreteau, Cecile H" uniqKey="Herbreteau C" first="Cécile H" last="Herbreteau">Cécile H. Herbreteau</name></region><name sortKey="Denizot, Melanie" sort="Denizot, Melanie" uniqKey="Denizot M" first="Mélanie" last="Denizot">Mélanie Denizot</name><name sortKey="Pasquier, Anais" sort="Pasquier, Anais" uniqKey="Pasquier A" first="Anaïs" last="Pasquier">Anaïs Pasquier</name><name sortKey="Saluzzo, Jean Francois" sort="Saluzzo, Jean Francois" uniqKey="Saluzzo J" first="Jean-François" last="Saluzzo">Jean-François Saluzzo</name></country><country name="Australie"><noRegion><name sortKey="Lowther, Suzanne" sort="Lowther, Suzanne" uniqKey="Lowther S" first="Suzanne" last="Lowther">Suzanne Lowther</name></noRegion><name sortKey="Arkinstall, Rachel" sort="Arkinstall, Rachel" uniqKey="Arkinstall R" first="Rachel" last="Arkinstall">Rachel Arkinstall</name><name sortKey="Frazer, Leah" sort="Frazer, Leah" uniqKey="Frazer L" first="Leah" last="Frazer">Leah Frazer</name><name sortKey="Haining, Jessica" sort="Haining, Jessica" uniqKey="Haining J" first="Jessica" last="Haining">Jessica Haining</name><name sortKey="Harper, Jenni" sort="Harper, Jenni" uniqKey="Harper J" first="Jenni" last="Harper">Jenni Harper</name><name sortKey="Johnson, Dayna" sort="Johnson, Dayna" uniqKey="Johnson D" first="Dayna" last="Johnson">Dayna Johnson</name><name sortKey="Middleton, Deborah" sort="Middleton, Deborah" uniqKey="Middleton D" first="Deborah" last="Middleton">Deborah Middleton</name><name sortKey="Payne, Jean" sort="Payne, Jean" uniqKey="Payne J" first="Jean" last="Payne">Jean Payne</name><name sortKey="Riddell, Sarah" sort="Riddell, Sarah" uniqKey="Riddell S" first="Sarah" last="Riddell">Sarah Riddell</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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