Emergence of Form from Function - Mechanical Engineering Approaches to Probe the Role of Stem Cell Mechanoadaptation in Sealing Cell Fate.
Identifieur interne : 001F52 ( PubMed/Checkpoint ); précédent : 001F51; suivant : 001F53Emergence of Form from Function - Mechanical Engineering Approaches to Probe the Role of Stem Cell Mechanoadaptation in Sealing Cell Fate.
Auteurs : Melissa L. Knothe Tate [Australie] ; Peter W. Gunning [Australie] ; Vittorio Sansalone [France]Source :
- Bioarchitecture [ 1949-100X ] ; 2016.
Abstract
Stem cell "mechanomics" refers to the effect of mechanical cues on stem cell and matrix biology, where cell shape and fate are intrinsic manifestations of form and function. Before specialization, the stem cell itself serves as a sensor and actuator; its structure emerges from its local mechanical milieu as the cell adapts over time. Coupling of novel spatiotemporal imaging and computational methods allows for linking of the energy of adaptation to the structure, biology and mechanical function of the cell. Cutting edge imaging methods enable probing of mechanisms by which stem cells' emergent anisotropic architecture and fate commitment occurs. A novel cell-scale model provides a mechanistic framework to describe stem cell growth and remodeling through mechanical feedback; making use of a generalized virtual power principle, the model accounts for the rate of doing work or the rate of using energy to effect the work. This coupled approach provides a basis to elucidate mechanisms underlying the stem cell's innate capacity to adapt to mechanical stimuli as well as the role of mechanoadaptation in lineage commitment. An understanding of stem cell mechanoadaptation is key to deciphering lineage commitment, during prenatal development, postnatal wound healing, and engineering of tissues.
DOI: 10.1080/19490992.2016.1229729
PubMed: 27739911
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Knothe Tate</name><affiliation wicri:level="1"><nlm:affiliation>a Graduate School of Biomedical Engineering , University of New South Wales , Sydney , Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>a Graduate School of Biomedical Engineering , University of New South Wales , Sydney </wicri:regionArea><wicri:noRegion>Sydney </wicri:noRegion></affiliation></author><author><name sortKey="Gunning, Peter W" sort="Gunning, Peter W" uniqKey="Gunning P" first="Peter W" last="Gunning">Peter W. Gunning</name><affiliation wicri:level="1"><nlm:affiliation>b School of Medical Sciences, University of New South Wales , Sydney , Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>b School of Medical Sciences, University of New South Wales , Sydney </wicri:regionArea><wicri:noRegion>Sydney </wicri:noRegion></affiliation></author><author><name sortKey="Sansalone, Vittorio" sort="Sansalone, Vittorio" uniqKey="Sansalone V" first="Vittorio" last="Sansalone">Vittorio Sansalone</name><affiliation wicri:level="1"><nlm:affiliation>c Université Paris-Est Créteil (UPEC), Laboratoire Modélisation et Simulation Multi Echelle , MSME UMR 8208 CNRS, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>c Université Paris-Est Créteil (UPEC), Laboratoire Modélisation et Simulation Multi Echelle , MSME UMR 8208 CNRS</wicri:regionArea><wicri:noRegion>MSME UMR 8208 CNRS</wicri:noRegion><wicri:noRegion>MSME UMR 8208 CNRS</wicri:noRegion></affiliation></author></analytic><series><title level="j">Bioarchitecture</title><idno type="eISSN">1949-100X</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Stem cell "mechanomics" refers to the effect of mechanical cues on stem cell and matrix biology, where cell shape and fate are intrinsic manifestations of form and function. Before specialization, the stem cell itself serves as a sensor and actuator; its structure emerges from its local mechanical milieu as the cell adapts over time. Coupling of novel spatiotemporal imaging and computational methods allows for linking of the energy of adaptation to the structure, biology and mechanical function of the cell. Cutting edge imaging methods enable probing of mechanisms by which stem cells' emergent anisotropic architecture and fate commitment occurs. A novel cell-scale model provides a mechanistic framework to describe stem cell growth and remodeling through mechanical feedback; making use of a generalized virtual power principle, the model accounts for the rate of doing work or the rate of using energy to effect the work. This coupled approach provides a basis to elucidate mechanisms underlying the stem cell's innate capacity to adapt to mechanical stimuli as well as the role of mechanoadaptation in lineage commitment. An understanding of stem cell mechanoadaptation is key to deciphering lineage commitment, during prenatal development, postnatal wound healing, and engineering of tissues.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">27739911</PMID><DateCreated><Year>2016</Year><Month>10</Month><Day>14</Day></DateCreated><DateRevised><Year>2017</Year><Month>10</Month><Day>14</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1949-100X</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2016</Year><Month>Oct</Month><Day>14</Day></PubDate></JournalIssue><Title>Bioarchitecture</Title><ISOAbbreviation>Bioarchitecture</ISOAbbreviation></Journal><ArticleTitle>Emergence of Form from Function - Mechanical Engineering Approaches to Probe the Role of Stem Cell Mechanoadaptation in Sealing Cell Fate.</ArticleTitle><Pagination><MedlinePgn>0</MedlinePgn></Pagination><Abstract><AbstractText>Stem cell "mechanomics" refers to the effect of mechanical cues on stem cell and matrix biology, where cell shape and fate are intrinsic manifestations of form and function. Before specialization, the stem cell itself serves as a sensor and actuator; its structure emerges from its local mechanical milieu as the cell adapts over time. Coupling of novel spatiotemporal imaging and computational methods allows for linking of the energy of adaptation to the structure, biology and mechanical function of the cell. Cutting edge imaging methods enable probing of mechanisms by which stem cells' emergent anisotropic architecture and fate commitment occurs. A novel cell-scale model provides a mechanistic framework to describe stem cell growth and remodeling through mechanical feedback; making use of a generalized virtual power principle, the model accounts for the rate of doing work or the rate of using energy to effect the work. This coupled approach provides a basis to elucidate mechanisms underlying the stem cell's innate capacity to adapt to mechanical stimuli as well as the role of mechanoadaptation in lineage commitment. An understanding of stem cell mechanoadaptation is key to deciphering lineage commitment, during prenatal development, postnatal wound healing, and engineering of tissues.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Knothe Tate</LastName><ForeName>Melissa L</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>a Graduate School of Biomedical Engineering , University of New South Wales , Sydney , Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gunning</LastName><ForeName>Peter W</ForeName><Initials>PW</Initials><AffiliationInfo><Affiliation>b School of Medical Sciences, University of New South Wales , Sydney , Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sansalone</LastName><ForeName>Vittorio</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>c Université Paris-Est Créteil (UPEC), Laboratoire Modélisation et Simulation Multi Echelle , MSME UMR 8208 CNRS, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>10</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Bioarchitecture</MedlineTA><NlmUniqueID>101518332</NlmUniqueID><ISSNLinking>1949-0992</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Tissue Eng. 2007 Oct;13(10):2525-38</RefSource><PMID Version="1">17822359</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Cell Sci. 2015 Jun 1;128(11):2009-19</RefSource><PMID Version="1">25788699</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Biol Cell. 2015 Jul 1;26(13):2475-90</RefSource><PMID Version="1">25971798</PMID></CommentsCorrections><CommentsCorrections 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Version="1">22338707</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Stem Cells Transl Med. 2016 Jul 28;:null</RefSource><PMID Version="1">27471309</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biomed Res Int. 2013;2013:598461</RefSource><PMID Version="1">23509748</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biophys J. 2009 Jan;96(2):717-28</RefSource><PMID Version="1">19167316</PMID></CommentsCorrections></CommentsCorrectionsList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">cell mechanics</Keyword><Keyword MajorTopicYN="N">fate</Keyword><Keyword MajorTopicYN="N">lineage commitment</Keyword><Keyword MajorTopicYN="N">mechanoadaptation</Keyword><Keyword MajorTopicYN="N">mechanomics</Keyword><Keyword MajorTopicYN="N">stem cell</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>10</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>10</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>10</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27739911</ArticleId><ArticleId IdType="doi">10.1080/19490992.2016.1229729</ArticleId><ArticleId IdType="pmc">PMC5077068</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>France</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Knothe Tate, Melissa L" sort="Knothe Tate, Melissa L" uniqKey="Knothe Tate M" first="Melissa L" last="Knothe Tate">Melissa L. Knothe Tate</name></noRegion><name sortKey="Gunning, Peter W" sort="Gunning, Peter W" uniqKey="Gunning P" first="Peter W" last="Gunning">Peter W. Gunning</name></country><country name="France"><noRegion><name sortKey="Sansalone, Vittorio" sort="Sansalone, Vittorio" uniqKey="Sansalone V" first="Vittorio" last="Sansalone">Vittorio Sansalone</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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