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Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome.

Identifieur interne : 001B56 ( PubMed/Checkpoint ); précédent : 001B55; suivant : 001B57

Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome.

Auteurs : Valerie M. Harris [États-Unis] ; Rohan Sharma [États-Unis] ; Joshua Cavett [États-Unis] ; Biji T. Kurien [États-Unis] ; Ke Liu [États-Unis] ; Kristi A. Koelsch [États-Unis] ; Astrid Rasmussen [États-Unis] ; Lida Radfar [États-Unis] ; David Lewis [États-Unis] ; Donald U. Stone [États-Unis] ; C Erick Kaufman [États-Unis] ; Shibo Li [États-Unis] ; Barbara Segal [États-Unis] ; Daniel J. Wallace [États-Unis] ; Michael H. Weisman [États-Unis] ; Swamy Venuturupalli [États-Unis] ; Jennifer A. Kelly [États-Unis] ; Marta E. Alarcon-Riquelme [Espagne] ; Bernardo Pons-Estel [Argentine] ; Roland Jonsson [Norvège] ; Xianglan Lu [États-Unis] ; Jacques-Eric Gottenberg [France] ; Juan-Manuel Anaya [Colombie] ; Deborah S. Cunninghame-Graham [Royaume-Uni] ; Andrew J W. Huang [États-Unis] ; Michael T. Brennan [États-Unis] ; Pamela Hughes [États-Unis] ; Ilias Alevizos [États-Unis] ; Corinne Miceli-Richard [France] ; Edward C. Keystone [Canada] ; Vivian P. Bykerk [États-Unis] ; Gideon Hirschfield [Royaume-Uni] ; Gang Xie [Canada] ; Wan-Fai Ng [Royaume-Uni] ; Gunnel Nordmark [Suède] ; Sara Magnusson Bucher [Suède] ; Per Eriksson [Norvège] ; Roald Omdal [Suède] ; Nelson L. Rhodus [États-Unis] ; Maureen Rischmueller [Australie] ; Michael Rohrer [États-Unis] ; Marie Wahren-Herlenius [Suède] ; Torsten Witte [Allemagne] ; Xavier Mariette [France] ; Christopher J. Lessard [États-Unis] ; John B. Harley [États-Unis] ; Kathy L. Sivils [États-Unis] ; R Hal Scofield [États-Unis]

Source :

Clinical immunology (Orlando, Fla.) [ 1521-7035 ] ; 2016.

RBID : pubmed:27109640

Descripteurs français

English descriptors

KwdEn :
- Arthritis, Rheumatoid (genetics), Chromosomes, Human, X (genetics), Chromosomes, Human, Y (genetics), Female, Gene Frequency, Genotype, Humans, Klinefelter Syndrome (genetics), Lupus Erythematosus, Systemic (genetics), Male, Polymorphism, Single Nucleotide, Sjogren's Syndrome (genetics).
MESH :
- genetics : Arthritis, Rheumatoid, Chromosomes, Human, X, Chromosomes, Human, Y, Klinefelter Syndrome, Lupus Erythematosus, Systemic, Sjogren's Syndrome.
- Female, Gene Frequency, Genotype, Humans, Male, Polymorphism, Single Nucleotide.

Abstract

Primary Sjögren's syndrome (pSS) has a strong female bias. We evaluated an X chromosome dose effect by analyzing 47,XXY (Klinefelter's syndrome, 1 in 500 live male births) among subjects with pSS. 47,XXY was determined by examination of fluorescence intensity of single nucleotide polymorphisms from the X and Y chromosomes. Among 136 pSS men there were 4 with 47,XXY. This was significantly different from healthy controls (1 of 1254 had 47,XXY, p=0.0012 by Fisher's exact test) as well men with rheumatoid arthritis (0 of 363 with 47,XXY), but not different compared to men with systemic lupus erythematosus (SLE) (4 of 136 versus 8 of 306, Fisher's exact test p=NS). These results are consistent with the hypothesis that the number of X chromosomes is critical for the female bias of pSS, a property that may be shared with SLE but not RA.

DOI: 10.1016/j.clim.2016.04.002
PubMed: 27109640

Affiliations:

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<author><name sortKey="Lewis, David" sort="Lewis, David" uniqKey="Lewis D" first="David" last="Lewis">David Lewis</name>
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<author><name sortKey="Stone, Donald U" sort="Stone, Donald U" uniqKey="Stone D" first="Donald U" last="Stone">Donald U. Stone</name>
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<author><name sortKey="Kaufman, C Erick" sort="Kaufman, C Erick" uniqKey="Kaufman C" first="C Erick" last="Kaufman">C Erick Kaufman</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK</wicri:regionArea>
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</affiliation>
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<author><name sortKey="Li, Shibo" sort="Li, Shibo" uniqKey="Li S" first="Shibo" last="Li">Shibo Li</name>
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<author><name sortKey="Segal, Barbara" sort="Segal, Barbara" uniqKey="Segal B" first="Barbara" last="Segal">Barbara Segal</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, University of Minnesota Medical School, Minneapolis, MN</wicri:regionArea>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Wallace, Daniel J" sort="Wallace, Daniel J" uniqKey="Wallace D" first="Daniel J" last="Wallace">Daniel J. Wallace</name>
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</placeName>
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<author><name sortKey="Weisman, Michael H" sort="Weisman, Michael H" uniqKey="Weisman M" first="Michael H" last="Weisman">Michael H. Weisman</name>
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<wicri:regionArea>Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Venuturupalli, Swamy" sort="Venuturupalli, Swamy" uniqKey="Venuturupalli S" first="Swamy" last="Venuturupalli">Swamy Venuturupalli</name>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Kelly, Jennifer A" sort="Kelly, Jennifer A" uniqKey="Kelly J" first="Jennifer A" last="Kelly">Jennifer A. Kelly</name>
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</placeName>
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<author><name sortKey="Alarcon Riquelme, Marta E" sort="Alarcon Riquelme, Marta E" uniqKey="Alarcon Riquelme M" first="Marta E" last="Alarcon-Riquelme">Marta E. Alarcon-Riquelme</name>
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<country xml:lang="fr">Espagne</country>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Pons Estel, Bernardo" sort="Pons Estel, Bernardo" uniqKey="Pons Estel B" first="Bernardo" last="Pons-Estel">Bernardo Pons-Estel</name>
<affiliation wicri:level="1"><nlm:affiliation>Sanatorio Parque, Rosario, Argentina.</nlm:affiliation>
<country xml:lang="fr">Argentine</country>
<wicri:regionArea>Sanatorio Parque, Rosario</wicri:regionArea>
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</affiliation>
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<author><name sortKey="Jonsson, Roland" sort="Jonsson, Roland" uniqKey="Jonsson R" first="Roland" last="Jonsson">Roland Jonsson</name>
<affiliation wicri:level="1"><nlm:affiliation>Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen 5021, Norway; Department of Rheumatology, Haukeland University Hospital, Bergen 5021, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen 5021, Norway; Department of Rheumatology, Haukeland University Hospital, Bergen 5021</wicri:regionArea>
<wicri:noRegion>Bergen 5021</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lu, Xianglan" sort="Lu, Xianglan" uniqKey="Lu X" first="Xianglan" last="Lu">Xianglan Lu</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gottenberg, Jacques Eric" sort="Gottenberg, Jacques Eric" uniqKey="Gottenberg J" first="Jacques-Eric" last="Gottenberg">Jacques-Eric Gottenberg</name>
<affiliation wicri:level="3"><nlm:affiliation>Strasbourg University, Strasbourg, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Strasbourg University, Strasbourg</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
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<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Anaya, Juan Manuel" sort="Anaya, Juan Manuel" uniqKey="Anaya J" first="Juan-Manuel" last="Anaya">Juan-Manuel Anaya</name>
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<country xml:lang="fr">Colombie</country>
<wicri:regionArea>Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Cunninghame Graham, Deborah S" sort="Cunninghame Graham, Deborah S" uniqKey="Cunninghame Graham D" first="Deborah S" last="Cunninghame-Graham">Deborah S. Cunninghame-Graham</name>
<affiliation wicri:level="3"><nlm:affiliation>Division of Genetics and Molecular Medicine and Division of Immunology, Infection and Inflammatory Disease, King's College London, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Genetics and Molecular Medicine and Division of Immunology, Infection and Inflammatory Disease, King's College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Huang, Andrew J W" sort="Huang, Andrew J W" uniqKey="Huang A" first="Andrew J W" last="Huang">Andrew J W. Huang</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brennan, Michael T" sort="Brennan, Michael T" uniqKey="Brennan M" first="Michael T" last="Brennan">Michael T. Brennan</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC 28232, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC 28232</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hughes, Pamela" sort="Hughes, Pamela" uniqKey="Hughes P" first="Pamela" last="Hughes">Pamela Hughes</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Alevizos, Ilias" sort="Alevizos, Ilias" uniqKey="Alevizos I" first="Ilias" last="Alevizos">Ilias Alevizos</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Molecular Physiology & Therapeutic Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Miceli Richard, Corinne" sort="Miceli Richard, Corinne" uniqKey="Miceli Richard C" first="Corinne" last="Miceli-Richard">Corinne Miceli-Richard</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Rheumatology, Université Paris-Sud, AP-HP, INSERM U1012, Le Kremlin-Bicêtre, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Rheumatology, Université Paris-Sud, AP-HP, INSERM U1012, Le Kremlin-Bicêtre</wicri:regionArea>
<wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion>
<orgName type="university">Université Paris-Sud</orgName>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Keystone, Edward C" sort="Keystone, Edward C" uniqKey="Keystone E" first="Edward C" last="Keystone">Edward C. Keystone</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medicine, Mount Sinai Hospital and University of Toronto, Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bykerk, Vivian P" sort="Bykerk, Vivian P" uniqKey="Bykerk V" first="Vivian P" last="Bykerk">Vivian P. Bykerk</name>
<affiliation wicri:level="2"><nlm:affiliation>Hospital for Special Surgery, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Hospital for Special Surgery, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hirschfield, Gideon" sort="Hirschfield, Gideon" uniqKey="Hirschfield G" first="Gideon" last="Hirschfield">Gideon Hirschfield</name>
<affiliation wicri:level="4"><nlm:affiliation>NIHR Biomedical Research Unit, University of Birmingham, Birmingham, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>NIHR Biomedical Research Unit, University of Birmingham, Birmingham</wicri:regionArea>
<placeName><settlement type="city">Birmingham</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Midlands de l'Ouest</region>
<settlement type="city">Birmingham</settlement>
</placeName>
<orgName type="university">Université de Birmingham</orgName>
</affiliation>
</author>
<author><name sortKey="Xie, Gang" sort="Xie, Gang" uniqKey="Xie G" first="Gang" last="Xie">Gang Xie</name>
<affiliation wicri:level="4"><nlm:affiliation>Samuel Lunenfeld and Toronto General Research Institutes, Departments of Medicine, Immunology and Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Samuel Lunenfeld and Toronto General Research Institutes, Departments of Medicine, Immunology and Molecular Genetics, University of Toronto, Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ng, Wan Fai" sort="Ng, Wan Fai" uniqKey="Ng W" first="Wan-Fai" last="Ng">Wan-Fai Ng</name>
<affiliation wicri:level="1"><nlm:affiliation>Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
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<author><name sortKey="Nordmark, Gunnel" sort="Nordmark, Gunnel" uniqKey="Nordmark G" first="Gunnel" last="Nordmark">Gunnel Nordmark</name>
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<country xml:lang="fr">Suède</country>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Bucher, Sara Magnusson" sort="Bucher, Sara Magnusson" uniqKey="Bucher S" first="Sara Magnusson" last="Bucher">Sara Magnusson Bucher</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Örebro University Hospital, Örebro, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
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</affiliation>
</author>
<author><name sortKey="Eriksson, Per" sort="Eriksson, Per" uniqKey="Eriksson P" first="Per" last="Eriksson">Per Eriksson</name>
<affiliation wicri:level="1"><nlm:affiliation>Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Omdal, Roald" sort="Omdal, Roald" uniqKey="Omdal R" first="Roald" last="Omdal">Roald Omdal</name>
<affiliation wicri:level="1"><nlm:affiliation>Rheumatology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Rheumatology, Department of Clinical and Experimental Medicine, Linköping University, Linköping</wicri:regionArea>
<wicri:noRegion>Linköping</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rhodus, Nelson L" sort="Rhodus, Nelson L" uniqKey="Rhodus N" first="Nelson L" last="Rhodus">Nelson L. Rhodus</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis</wicri:regionArea>
<wicri:noRegion>Minneapolis</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rischmueller, Maureen" sort="Rischmueller, Maureen" uniqKey="Rischmueller M" first="Maureen" last="Rischmueller">Maureen Rischmueller</name>
<affiliation wicri:level="1"><nlm:affiliation>Rheumatology Department, The Queen Elizabeth Hospital, Woodville South, SA 5011, Australia; Discipline of Medicine, University of Adelaide, Adelaide, SA 5000, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Rheumatology Department, The Queen Elizabeth Hospital, Woodville South, SA 5011, Australia; Discipline of Medicine, University of Adelaide, Adelaide, SA 5000</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Rohrer, Michael" sort="Rohrer, Michael" uniqKey="Rohrer M" first="Michael" last="Rohrer">Michael Rohrer</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wahren Herlenius, Marie" sort="Wahren Herlenius, Marie" uniqKey="Wahren Herlenius M" first="Marie" last="Wahren-Herlenius">Marie Wahren-Herlenius</name>
<affiliation wicri:level="3"><nlm:affiliation>Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Witte, Torsten" sort="Witte, Torsten" uniqKey="Witte T" first="Torsten" last="Witte">Torsten Witte</name>
<affiliation wicri:level="3"><nlm:affiliation>Clinic for Immunology and Rheumatology, Hannover Medical School, 30625 Hannover, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Clinic for Immunology and Rheumatology, Hannover Medical School, 30625 Hannover</wicri:regionArea>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Rheumatology, Université Paris-Sud, AP-HP, INSERM U1012, Le Kremlin-Bicêtre, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Rheumatology, Université Paris-Sud, AP-HP, INSERM U1012, Le Kremlin-Bicêtre</wicri:regionArea>
<wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion>
<orgName type="university">Université Paris-Sud</orgName>
<placeName><settlement type="city">Orsay</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lessard, Christopher J" sort="Lessard, Christopher J" uniqKey="Lessard C" first="Christopher J" last="Lessard">Christopher J. Lessard</name>
<affiliation wicri:level="2"><nlm:affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Harley, John B" sort="Harley, John B" uniqKey="Harley J" first="John B" last="Harley">John B. Harley</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; College of Medicine, University of Cincinnati, Cincinnati, OH, USA; Medical Service, Department of Veterans Affairs Medical Center, Cincinnati, OH, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; College of Medicine, University of Cincinnati, Cincinnati, OH, USA; Medical Service, Department of Veterans Affairs Medical Center, Cincinnati, OH</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sivils, Kathy L" sort="Sivils, Kathy L" uniqKey="Sivils K" first="Kathy L" last="Sivils">Kathy L. Sivils</name>
<affiliation wicri:level="2"><nlm:affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Scofield, R Hal" sort="Scofield, R Hal" uniqKey="Scofield R" first="R Hal" last="Scofield">R Hal Scofield</name>
<affiliation wicri:level="2"><nlm:affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA. Electronic address: hal-scofield@omrf.ouhsc.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome.</title>
<author><name sortKey="Harris, Valerie M" sort="Harris, Valerie M" uniqKey="Harris V" first="Valerie M" last="Harris">Valerie M. Harris</name>
<affiliation wicri:level="2"><nlm:affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sharma, Rohan" sort="Sharma, Rohan" uniqKey="Sharma R" first="Rohan" last="Sharma">Rohan Sharma</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cavett, Joshua" sort="Cavett, Joshua" uniqKey="Cavett J" first="Joshua" last="Cavett">Joshua Cavett</name>
<affiliation wicri:level="2"><nlm:affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kurien, Biji T" sort="Kurien, Biji T" uniqKey="Kurien B" first="Biji T" last="Kurien">Biji T. Kurien</name>
<affiliation wicri:level="2"><nlm:affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liu, Ke" sort="Liu, Ke" uniqKey="Liu K" first="Ke" last="Liu">Ke Liu</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; College of Medicine, University of Cincinnati, Cincinnati, OH, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; College of Medicine, University of Cincinnati, Cincinnati, OH</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Koelsch, Kristi A" sort="Koelsch, Kristi A" uniqKey="Koelsch K" first="Kristi A" last="Koelsch">Kristi A. Koelsch</name>
<affiliation wicri:level="2"><nlm:affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rasmussen, Astrid" sort="Rasmussen, Astrid" uniqKey="Rasmussen A" first="Astrid" last="Rasmussen">Astrid Rasmussen</name>
<affiliation wicri:level="2"><nlm:affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Radfar, Lida" sort="Radfar, Lida" uniqKey="Radfar L" first="Lida" last="Radfar">Lida Radfar</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Oral Diagnosis and Radiology, College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Oral Diagnosis and Radiology, College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City</wicri:regionArea>
<wicri:noRegion>Oklahoma City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lewis, David" sort="Lewis, David" uniqKey="Lewis D" first="David" last="Lewis">David Lewis</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Oral Diagnosis and Radiology, College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Oral Diagnosis and Radiology, College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City</wicri:regionArea>
<wicri:noRegion>Oklahoma City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stone, Donald U" sort="Stone, Donald U" uniqKey="Stone D" first="Donald U" last="Stone">Donald U. Stone</name>
<affiliation wicri:level="2"><nlm:affiliation>Dean McGee Eye Institute and Department of Ophthalmology, University of Oklahoma College of Medicine, Oklahoma City, OK, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Dean McGee Eye Institute and Department of Ophthalmology, University of Oklahoma College of Medicine, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kaufman, C Erick" sort="Kaufman, C Erick" uniqKey="Kaufman C" first="C Erick" last="Kaufman">C Erick Kaufman</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Shibo" sort="Li, Shibo" uniqKey="Li S" first="Shibo" last="Li">Shibo Li</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Segal, Barbara" sort="Segal, Barbara" uniqKey="Segal B" first="Barbara" last="Segal">Barbara Segal</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, University of Minnesota Medical School, Minneapolis, MN</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wallace, Daniel J" sort="Wallace, Daniel J" uniqKey="Wallace D" first="Daniel J" last="Wallace">Daniel J. Wallace</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Weisman, Michael H" sort="Weisman, Michael H" uniqKey="Weisman M" first="Michael H" last="Weisman">Michael H. Weisman</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Venuturupalli, Swamy" sort="Venuturupalli, Swamy" uniqKey="Venuturupalli S" first="Swamy" last="Venuturupalli">Swamy Venuturupalli</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kelly, Jennifer A" sort="Kelly, Jennifer A" uniqKey="Kelly J" first="Jennifer A" last="Kelly">Jennifer A. Kelly</name>
<affiliation wicri:level="2"><nlm:affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Alarcon Riquelme, Marta E" sort="Alarcon Riquelme, Marta E" uniqKey="Alarcon Riquelme M" first="Marta E" last="Alarcon-Riquelme">Marta E. Alarcon-Riquelme</name>
<affiliation wicri:level="4"><nlm:affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Center Pfizer, University of Granada, Andalusian Government for Genomics and Oncological Research, PTS Granada, 18016, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Center Pfizer, University of Granada, Andalusian Government for Genomics and Oncological Research, PTS Granada, 18016</wicri:regionArea>
<orgName type="university">Université de Grenade</orgName>
<placeName><settlement type="city">Grenade (Espagne)</settlement>
<region nuts="2" type="region">Andalousie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pons Estel, Bernardo" sort="Pons Estel, Bernardo" uniqKey="Pons Estel B" first="Bernardo" last="Pons-Estel">Bernardo Pons-Estel</name>
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<country xml:lang="fr">Argentine</country>
<wicri:regionArea>Sanatorio Parque, Rosario</wicri:regionArea>
<wicri:noRegion>Rosario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jonsson, Roland" sort="Jonsson, Roland" uniqKey="Jonsson R" first="Roland" last="Jonsson">Roland Jonsson</name>
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<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen 5021, Norway; Department of Rheumatology, Haukeland University Hospital, Bergen 5021</wicri:regionArea>
<wicri:noRegion>Bergen 5021</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lu, Xianglan" sort="Lu, Xianglan" uniqKey="Lu X" first="Xianglan" last="Lu">Xianglan Lu</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gottenberg, Jacques Eric" sort="Gottenberg, Jacques Eric" uniqKey="Gottenberg J" first="Jacques-Eric" last="Gottenberg">Jacques-Eric Gottenberg</name>
<affiliation wicri:level="3"><nlm:affiliation>Strasbourg University, Strasbourg, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Strasbourg University, Strasbourg</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Anaya, Juan Manuel" sort="Anaya, Juan Manuel" uniqKey="Anaya J" first="Juan-Manuel" last="Anaya">Juan-Manuel Anaya</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia.</nlm:affiliation>
<country xml:lang="fr">Colombie</country>
<wicri:regionArea>Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota</wicri:regionArea>
<wicri:noRegion>Bogota</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cunninghame Graham, Deborah S" sort="Cunninghame Graham, Deborah S" uniqKey="Cunninghame Graham D" first="Deborah S" last="Cunninghame-Graham">Deborah S. Cunninghame-Graham</name>
<affiliation wicri:level="3"><nlm:affiliation>Division of Genetics and Molecular Medicine and Division of Immunology, Infection and Inflammatory Disease, King's College London, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Genetics and Molecular Medicine and Division of Immunology, Infection and Inflammatory Disease, King's College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Huang, Andrew J W" sort="Huang, Andrew J W" uniqKey="Huang A" first="Andrew J W" last="Huang">Andrew J W. Huang</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brennan, Michael T" sort="Brennan, Michael T" uniqKey="Brennan M" first="Michael T" last="Brennan">Michael T. Brennan</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC 28232, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC 28232</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hughes, Pamela" sort="Hughes, Pamela" uniqKey="Hughes P" first="Pamela" last="Hughes">Pamela Hughes</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Alevizos, Ilias" sort="Alevizos, Ilias" uniqKey="Alevizos I" first="Ilias" last="Alevizos">Ilias Alevizos</name>
<affiliation wicri:level="2"><nlm:affiliation>Molecular Physiology & Therapeutic Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Molecular Physiology & Therapeutic Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Miceli Richard, Corinne" sort="Miceli Richard, Corinne" uniqKey="Miceli Richard C" first="Corinne" last="Miceli-Richard">Corinne Miceli-Richard</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Rheumatology, Université Paris-Sud, AP-HP, INSERM U1012, Le Kremlin-Bicêtre, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Rheumatology, Université Paris-Sud, AP-HP, INSERM U1012, Le Kremlin-Bicêtre</wicri:regionArea>
<wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion>
<orgName type="university">Université Paris-Sud</orgName>
<placeName><settlement type="city">Orsay</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Keystone, Edward C" sort="Keystone, Edward C" uniqKey="Keystone E" first="Edward C" last="Keystone">Edward C. Keystone</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medicine, Mount Sinai Hospital and University of Toronto, Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bykerk, Vivian P" sort="Bykerk, Vivian P" uniqKey="Bykerk V" first="Vivian P" last="Bykerk">Vivian P. Bykerk</name>
<affiliation wicri:level="2"><nlm:affiliation>Hospital for Special Surgery, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Hospital for Special Surgery, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hirschfield, Gideon" sort="Hirschfield, Gideon" uniqKey="Hirschfield G" first="Gideon" last="Hirschfield">Gideon Hirschfield</name>
<affiliation wicri:level="4"><nlm:affiliation>NIHR Biomedical Research Unit, University of Birmingham, Birmingham, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>NIHR Biomedical Research Unit, University of Birmingham, Birmingham</wicri:regionArea>
<placeName><settlement type="city">Birmingham</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Midlands de l'Ouest</region>
<settlement type="city">Birmingham</settlement>
</placeName>
<orgName type="university">Université de Birmingham</orgName>
</affiliation>
</author>
<author><name sortKey="Xie, Gang" sort="Xie, Gang" uniqKey="Xie G" first="Gang" last="Xie">Gang Xie</name>
<affiliation wicri:level="4"><nlm:affiliation>Samuel Lunenfeld and Toronto General Research Institutes, Departments of Medicine, Immunology and Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Samuel Lunenfeld and Toronto General Research Institutes, Departments of Medicine, Immunology and Molecular Genetics, University of Toronto, Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ng, Wan Fai" sort="Ng, Wan Fai" uniqKey="Ng W" first="Wan-Fai" last="Ng">Wan-Fai Ng</name>
<affiliation wicri:level="1"><nlm:affiliation>Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne</wicri:regionArea>
<wicri:noRegion>Newcastle upon Tyne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nordmark, Gunnel" sort="Nordmark, Gunnel" uniqKey="Nordmark G" first="Gunnel" last="Nordmark">Gunnel Nordmark</name>
<affiliation wicri:level="4"><nlm:affiliation>Section of Rheumatology, Department of Medical Sciences and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Section of Rheumatology, Department of Medical Sciences and Science for Life Laboratory, Uppsala University, Uppsala</wicri:regionArea>
<orgName type="university">Université d'Uppsala</orgName>
<placeName><settlement type="city">Uppsala</settlement>
<region nuts="1">Svealand</region>
<region nuts="1">East Middle Sweden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bucher, Sara Magnusson" sort="Bucher, Sara Magnusson" uniqKey="Bucher S" first="Sara Magnusson" last="Bucher">Sara Magnusson Bucher</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Örebro University Hospital, Örebro, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Rheumatology, Örebro University Hospital, Örebro</wicri:regionArea>
<wicri:noRegion>Örebro</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Eriksson, Per" sort="Eriksson, Per" uniqKey="Eriksson P" first="Per" last="Eriksson">Per Eriksson</name>
<affiliation wicri:level="1"><nlm:affiliation>Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger</wicri:regionArea>
<wicri:noRegion>Stavanger</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Omdal, Roald" sort="Omdal, Roald" uniqKey="Omdal R" first="Roald" last="Omdal">Roald Omdal</name>
<affiliation wicri:level="1"><nlm:affiliation>Rheumatology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Rheumatology, Department of Clinical and Experimental Medicine, Linköping University, Linköping</wicri:regionArea>
<wicri:noRegion>Linköping</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rhodus, Nelson L" sort="Rhodus, Nelson L" uniqKey="Rhodus N" first="Nelson L" last="Rhodus">Nelson L. Rhodus</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis</wicri:regionArea>
<wicri:noRegion>Minneapolis</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rischmueller, Maureen" sort="Rischmueller, Maureen" uniqKey="Rischmueller M" first="Maureen" last="Rischmueller">Maureen Rischmueller</name>
<affiliation wicri:level="1"><nlm:affiliation>Rheumatology Department, The Queen Elizabeth Hospital, Woodville South, SA 5011, Australia; Discipline of Medicine, University of Adelaide, Adelaide, SA 5000, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Rheumatology Department, The Queen Elizabeth Hospital, Woodville South, SA 5011, Australia; Discipline of Medicine, University of Adelaide, Adelaide, SA 5000</wicri:regionArea>
<wicri:noRegion>SA 5000</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rohrer, Michael" sort="Rohrer, Michael" uniqKey="Rohrer M" first="Michael" last="Rohrer">Michael Rohrer</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wahren Herlenius, Marie" sort="Wahren Herlenius, Marie" uniqKey="Wahren Herlenius M" first="Marie" last="Wahren-Herlenius">Marie Wahren-Herlenius</name>
<affiliation wicri:level="3"><nlm:affiliation>Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Witte, Torsten" sort="Witte, Torsten" uniqKey="Witte T" first="Torsten" last="Witte">Torsten Witte</name>
<affiliation wicri:level="3"><nlm:affiliation>Clinic for Immunology and Rheumatology, Hannover Medical School, 30625 Hannover, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Clinic for Immunology and Rheumatology, Hannover Medical School, 30625 Hannover</wicri:regionArea>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Rheumatology, Université Paris-Sud, AP-HP, INSERM U1012, Le Kremlin-Bicêtre, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Rheumatology, Université Paris-Sud, AP-HP, INSERM U1012, Le Kremlin-Bicêtre</wicri:regionArea>
<wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion>
<orgName type="university">Université Paris-Sud</orgName>
<placeName><settlement type="city">Orsay</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lessard, Christopher J" sort="Lessard, Christopher J" uniqKey="Lessard C" first="Christopher J" last="Lessard">Christopher J. Lessard</name>
<affiliation wicri:level="2"><nlm:affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Harley, John B" sort="Harley, John B" uniqKey="Harley J" first="John B" last="Harley">John B. Harley</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; College of Medicine, University of Cincinnati, Cincinnati, OH, USA; Medical Service, Department of Veterans Affairs Medical Center, Cincinnati, OH, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; College of Medicine, University of Cincinnati, Cincinnati, OH, USA; Medical Service, Department of Veterans Affairs Medical Center, Cincinnati, OH</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sivils, Kathy L" sort="Sivils, Kathy L" uniqKey="Sivils K" first="Kathy L" last="Sivils">Kathy L. Sivils</name>
<affiliation wicri:level="2"><nlm:affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Scofield, R Hal" sort="Scofield, R Hal" uniqKey="Scofield R" first="R Hal" last="Scofield">R Hal Scofield</name>
<affiliation wicri:level="2"><nlm:affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA. Electronic address: hal-scofield@omrf.ouhsc.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Clinical immunology (Orlando, Fla.)</title>
<idno type="eISSN">1521-7035</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arthritis, Rheumatoid (genetics)</term>
<term>Chromosomes, Human, X (genetics)</term>
<term>Chromosomes, Human, Y (genetics)</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genotype</term>
<term>Humans</term>
<term>Klinefelter Syndrome (genetics)</term>
<term>Lupus Erythematosus, Systemic (genetics)</term>
<term>Male</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Sjogren's Syndrome (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Chromosomes X humains (génétique)</term>
<term>Chromosomes Y humains (génétique)</term>
<term>Femelle</term>
<term>Fréquence d'allèle</term>
<term>Génotype</term>
<term>Humains</term>
<term>Lupus érythémateux disséminé (génétique)</term>
<term>Mâle</term>
<term>Polyarthrite rhumatoïde (génétique)</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Syndrome de Gougerot-Sjögren (génétique)</term>
<term>Syndrome de Klinefelter (génétique)</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Arthritis, Rheumatoid</term>
<term>Chromosomes, Human, X</term>
<term>Chromosomes, Human, Y</term>
<term>Klinefelter Syndrome</term>
<term>Lupus Erythematosus, Systemic</term>
<term>Sjogren's Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Chromosomes X humains</term>
<term>Chromosomes Y humains</term>
<term>Lupus érythémateux disséminé</term>
<term>Polyarthrite rhumatoïde</term>
<term>Syndrome de Gougerot-Sjögren</term>
<term>Syndrome de Klinefelter</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Female</term>
<term>Gene Frequency</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Polymorphism, Single Nucleotide</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Femelle</term>
<term>Fréquence d'allèle</term>
<term>Génotype</term>
<term>Humains</term>
<term>Mâle</term>
<term>Polymorphisme de nucléotide simple</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Primary Sjögren's syndrome (pSS) has a strong female bias. We evaluated an X chromosome dose effect by analyzing 47,XXY (Klinefelter's syndrome, 1 in 500 live male births) among subjects with pSS. 47,XXY was determined by examination of fluorescence intensity of single nucleotide polymorphisms from the X and Y chromosomes. Among 136 pSS men there were 4 with 47,XXY. This was significantly different from healthy controls (1 of 1254 had 47,XXY, p=0.0012 by Fisher's exact test) as well men with rheumatoid arthritis (0 of 363 with 47,XXY), but not different compared to men with systemic lupus erythematosus (SLE) (4 of 136 versus 8 of 306, Fisher's exact test p=NS). These results are consistent with the hypothesis that the number of X chromosomes is critical for the female bias of pSS, a property that may be shared with SLE but not RA.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27109640</PMID>
<DateCreated><Year>2016</Year>
<Month>07</Month>
<Day>11</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>03</Month>
<Day>30</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>09</Month>
<Day>22</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1521-7035</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>168</Volume>
<PubDate><Year>2016</Year>
<Month>07</Month>
</PubDate>
</JournalIssue>
<Title>Clinical immunology (Orlando, Fla.)</Title>
<ISOAbbreviation>Clin. Immunol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome.</ArticleTitle>
<Pagination><MedlinePgn>25-29</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S1521-6616(16)30061-4</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.clim.2016.04.002</ELocationID>
<Abstract><AbstractText>Primary Sjögren's syndrome (pSS) has a strong female bias. We evaluated an X chromosome dose effect by analyzing 47,XXY (Klinefelter's syndrome, 1 in 500 live male births) among subjects with pSS. 47,XXY was determined by examination of fluorescence intensity of single nucleotide polymorphisms from the X and Y chromosomes. Among 136 pSS men there were 4 with 47,XXY. This was significantly different from healthy controls (1 of 1254 had 47,XXY, p=0.0012 by Fisher's exact test) as well men with rheumatoid arthritis (0 of 363 with 47,XXY), but not different compared to men with systemic lupus erythematosus (SLE) (4 of 136 versus 8 of 306, Fisher's exact test p=NS). These results are consistent with the hypothesis that the number of X chromosomes is critical for the female bias of pSS, a property that may be shared with SLE but not RA.</AbstractText>
<CopyrightInformation>Published by Elsevier Inc.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Harris</LastName>
<ForeName>Valerie M</ForeName>
<Initials>VM</Initials>
<AffiliationInfo><Affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sharma</LastName>
<ForeName>Rohan</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cavett</LastName>
<ForeName>Joshua</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kurien</LastName>
<ForeName>Biji T</ForeName>
<Initials>BT</Initials>
<AffiliationInfo><Affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Ke</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; College of Medicine, University of Cincinnati, Cincinnati, OH, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Koelsch</LastName>
<ForeName>Kristi A</ForeName>
<Initials>KA</Initials>
<AffiliationInfo><Affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rasmussen</LastName>
<ForeName>Astrid</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Radfar</LastName>
<ForeName>Lida</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Oral Diagnosis and Radiology, College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lewis</LastName>
<ForeName>David</ForeName>
<Initials>D</Initials>
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<Initials>G</Initials>
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<Author ValidYN="Y"><LastName>Nordmark</LastName>
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<Initials>G</Initials>
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<AffiliationInfo><Affiliation>Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, USA.</Affiliation>
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<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, USA.</Affiliation>
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<Initials>M</Initials>
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<Initials>T</Initials>
<AffiliationInfo><Affiliation>Clinic for Immunology and Rheumatology, Hannover Medical School, 30625 Hannover, Germany.</Affiliation>
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<Initials>X</Initials>
<AffiliationInfo><Affiliation>Department of Rheumatology, Université Paris-Sud, AP-HP, INSERM U1012, Le Kremlin-Bicêtre, France.</Affiliation>
</AffiliationInfo>
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<AffiliationInfo><Affiliation>Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.</Affiliation>
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<country name="Suède"><region name="Svealand"><name sortKey="Nordmark, Gunnel" sort="Nordmark, Gunnel" uniqKey="Nordmark G" first="Gunnel" last="Nordmark">Gunnel Nordmark</name>
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<name sortKey="Bucher, Sara Magnusson" sort="Bucher, Sara Magnusson" uniqKey="Bucher S" first="Sara Magnusson" last="Bucher">Sara Magnusson Bucher</name>
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<name sortKey="Wahren Herlenius, Marie" sort="Wahren Herlenius, Marie" uniqKey="Wahren Herlenius M" first="Marie" last="Wahren-Herlenius">Marie Wahren-Herlenius</name>
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<country name="Australie"><noRegion><name sortKey="Rischmueller, Maureen" sort="Rischmueller, Maureen" uniqKey="Rischmueller M" first="Maureen" last="Rischmueller">Maureen Rischmueller</name>
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<country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Witte, Torsten" sort="Witte, Torsten" uniqKey="Witte T" first="Torsten" last="Witte">Torsten Witte</name>
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	Serveur d'exploration sur les relations entre la France et l'Australie
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Serveur d'exploration sur les relations entre la France et l'Australie

Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome.

Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome.

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