Neurocognition and quality of life after reinitiating antiretroviral therapy in children randomized to planned treatment interruption.
Identifieur interne : 001A01 ( PubMed/Checkpoint ); précédent : 001A00; suivant : 001A02Neurocognition and quality of life after reinitiating antiretroviral therapy in children randomized to planned treatment interruption.
Auteurs : Jintanat Ananworanich [États-Unis] ; Diane Melvin ; Jose T R. Amador ; Tristan Childs ; Gabriela Medin ; Valentina Boscolo ; Alexandra Compagnucci ; Suparat Kanjanavanit ; Samuel Montero ; Diana M. GibbSource :
- AIDS (London, England) [ 1473-5571 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Infections à VIH.
- psychologie : Infections à VIH.
- traitement médicamenteux : Infections à VIH.
- usage thérapeutique : Antirétroviraux.
- Adolescent, Cognition, Enfant, Femelle, Humains, Mâle, Qualité de vie, Résultat thérapeutique, Thérapie antirétrovirale hautement active.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Anti-Retroviral Agents.
- drug therapy : HIV Infections.
- methods : Antiretroviral Therapy, Highly Active.
- pathology : HIV Infections.
- psychology : HIV Infections.
- Adolescent, Child, Cognition, Female, Humans, Male, Quality of Life, Treatment Outcome.
Abstract
Understanding the effects of antiretroviral treatment (ART) interruption on neurocognition and quality of life (QoL) are important for managing unplanned interruptions and planned interruptions in HIV cure research.
DOI: 10.1097/QAD.0000000000001011
PubMed: 26730569
Affiliations:
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pubmed:26730569Le document en format XML
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<term>HIV Infections (pathology)</term>
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<term>Femelle</term>
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<term>Infections à VIH (anatomopathologie)</term>
<term>Infections à VIH (psychologie)</term>
<term>Infections à VIH (traitement médicamenteux)</term>
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<front><div type="abstract" xml:lang="en">Understanding the effects of antiretroviral treatment (ART) interruption on neurocognition and quality of life (QoL) are important for managing unplanned interruptions and planned interruptions in HIV cure research.</div>
</front>
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<Month>12</Month>
<Day>16</Day>
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<Month>12</Month>
<Day>17</Day>
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<JournalIssue CitedMedium="Internet"><Volume>30</Volume>
<Issue>7</Issue>
<PubDate><Year>2016</Year>
<Month>Apr</Month>
<Day>24</Day>
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<Title>AIDS (London, England)</Title>
<ISOAbbreviation>AIDS</ISOAbbreviation>
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<ArticleTitle>Neurocognition and quality of life after reinitiating antiretroviral therapy in children randomized to planned treatment interruption.</ArticleTitle>
<Pagination><MedlinePgn>1075-81</MedlinePgn>
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<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Understanding the effects of antiretroviral treatment (ART) interruption on neurocognition and quality of life (QoL) are important for managing unplanned interruptions and planned interruptions in HIV cure research.</AbstractText>
<AbstractText Label="DESIGN" NlmCategory="METHODS">Children previously randomized to continuous (continuous ART, n = 41) vs. planned treatment interruption (PTI, n = 47) in the Pediatric European Network for Treatment of AIDS (PENTA) 11 study were enrolled. At study end, PTI children resumed ART. At 1 and 2 years following study end, children were assessed by the coding, symbol search and digit span subtests of Wechsler Intelligence Scale for Children (6-16 years old) or Wechsler Adult Intelligence Scale (≥17 years old) and by Pediatrics QoL questionnaires for physical and psychological QoL. Transformed scaled scores for neurocognition and mean standardized scores for QoL were compared between arms by t-test and Mann-Whitney U test, respectively. Scores indicating clinical concern were compared (<7 for neurocognition and <70 for QoL tests).</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Characteristics were similar between arms with a median age of 12.6 years, CD4⁺ of 830 cells/μl and HIV RNA of 1.7 log10copies/ml. The median cumulative ART exposure was 9.6 in continuous ART vs. 7.7 years in PTI (P = 0.02). PTI children had a median of 12 months off ART and had resumed ART for 25.2 months at time of first assessment. Neurocognitive scores were similar between arms for all tests. Physical and psychological QoL scores were no different. About 40% had low neurocognitive and QoL scores indicating clinical concern.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">No differences in information processing speed, sustained attention, short-term memory and QoL functioning were observed between children previously randomized to continuous ART vs. PTI in the PENTA 11 trial.</AbstractText>
</Abstract>
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<Initials>MJ</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Nadal</LastName>
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<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Nastouli</LastName>
<ForeName>E</ForeName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Naver</LastName>
<ForeName>L</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Niehues</LastName>
<ForeName>T</ForeName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Peckham</LastName>
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<Initials>C</Initials>
</Investigator>
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<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Popieska</LastName>
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<Initials>J</Initials>
</Investigator>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Rojo Conejo</LastName>
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<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Rosado</LastName>
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<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Rosso</LastName>
<ForeName>R</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Rudin</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Scherpbier</LastName>
<ForeName>H J</ForeName>
<Initials>HJ</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Sharland</LastName>
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<Investigator ValidYN="Y"><LastName>Stevanovic</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Thorne</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Tovo</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Tudor-Williams</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Turkova</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Valerius</LastName>
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<Investigator ValidYN="Y"><LastName>Volokha</LastName>
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<Investigator ValidYN="Y"><LastName>Welch</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Wintergerst</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Aboulker</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Babiker</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Burger</LastName>
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</Investigator>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Darbyshire</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Giaquinto</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Gibb</LastName>
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<Investigator ValidYN="Y"><LastName>Green</LastName>
<ForeName>H</ForeName>
<Initials>H</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Harper</LastName>
<ForeName>L</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Klein</LastName>
<ForeName>N</ForeName>
<Initials>N</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Lallemant</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Lyall</LastName>
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<Initials>H</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Mofenson</LastName>
<ForeName>L</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Moye</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Nadal</LastName>
<ForeName>D</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Saïdi</LastName>
<ForeName>Y</ForeName>
<Initials>Y</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Burger</LastName>
<ForeName>D M</ForeName>
<Initials>DM</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Cressey</LastName>
<ForeName>T R</ForeName>
<Initials>TR</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Jacqz-Aigrain</LastName>
<ForeName>E</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Khoo</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Regazzi</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Tréluyer</LastName>
<ForeName>J M</ForeName>
<Initials>JM</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>De Rossi</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Klein</LastName>
<ForeName>N</ForeName>
<Initials>N</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Moye</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ngo-Giang-Huong</LastName>
<ForeName>N</ForeName>
<Initials>N</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Muñoz Fernandez</LastName>
<ForeName>M A</ForeName>
<Initials>MA</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Pillay</LastName>
<ForeName>D</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Hill</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Lepage</LastName>
<ForeName>P</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Pozniak</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Vella</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Chêne</LastName>
<ForeName>G</ForeName>
<Initials>G</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Vesikari</LastName>
<ForeName>T</ForeName>
<Initials>T</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Aboulker</LastName>
<ForeName>J P</ForeName>
<Initials>JP</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Compagnucci</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Hadjou</LastName>
<ForeName>G</ForeName>
<Initials>G</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Léonardo</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Riault</LastName>
<ForeName>Y</ForeName>
<Initials>Y</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Saïdi</LastName>
<ForeName>Y</ForeName>
<Initials>Y</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Babiker</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Bleier</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Buck</LastName>
<ForeName>L</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Castro</LastName>
<ForeName>H</ForeName>
<Initials>H</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Darbyshire</LastName>
<ForeName>J H</ForeName>
<Initials>JH</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Duong</LastName>
<ForeName>T</ForeName>
<Initials>T</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Farrelly</LastName>
<ForeName>L</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Forcat</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Gibb</LastName>
<ForeName>D M</ForeName>
<Initials>DM</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Harper</LastName>
<ForeName>L</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Harrison</LastName>
<ForeName>L</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Horton</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Johnson</LastName>
<ForeName>D</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Montero</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Taylor</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Walker</LastName>
<ForeName>A S</ForeName>
<Initials>AS</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Chalermpantmetagul</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Cressey</LastName>
<ForeName>T R</ForeName>
<Initials>TR</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Peongjakta</LastName>
<ForeName>R</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Khamjakkaew</LastName>
<ForeName>W</ForeName>
<Initials>W</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Than-in-at</LastName>
<ForeName>K</ForeName>
<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Chailert</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Jourdain</LastName>
<ForeName>G</ForeName>
<Initials>G</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Lallemant</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Le Coeur</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ngo-Giang-Huong</LastName>
<ForeName>N</ForeName>
<Initials>N</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Floret</LastName>
<ForeName>D</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Costanzo</LastName>
<ForeName>P</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Le Thi</LastName>
<ForeName>T T</ForeName>
<Initials>TT</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Monpoux</LastName>
<ForeName>F</ForeName>
<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Mellul</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Caranta</LastName>
<ForeName>I</ForeName>
<Initials>I</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Boudjoudi</LastName>
<ForeName>N</ForeName>
<Initials>N</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Firtion</LastName>
<ForeName>G</ForeName>
<Initials>G</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Denon</LastName>
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<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Charlemaine</LastName>
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<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Picard</LastName>
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<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Faye</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Hellier</LastName>
<ForeName>E</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Heuninck</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Damond</LastName>
<ForeName>F</ForeName>
<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Alexandre</LastName>
<ForeName>G</ForeName>
<Initials>G</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Tricoire</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Antras</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Lachendowier</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Nicot</LastName>
<ForeName>F</ForeName>
<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Krivine</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Rivaux</LastName>
<ForeName>D</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Wintergerst</LastName>
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<Initials>U</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Notheis</LastName>
<ForeName>G</ForeName>
<Initials>G</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Strotmann</LastName>
<ForeName>G</ForeName>
<Initials>G</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Schlieben</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Giaquinto</LastName>
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<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Rampon</LastName>
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<Initials>O</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Boscolo</LastName>
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<Initials>V</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Zanchetta</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Rosso</LastName>
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<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ginocchio</LastName>
<ForeName>F</ForeName>
<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Viscoli</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>di Biagio</LastName>
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<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Castelli-Gattinara</LastName>
<ForeName>G</ForeName>
<Initials>G</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Bernardi</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Martino</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Pontrelli</LastName>
<ForeName>G</ForeName>
<Initials>G</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Baldassar</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Concato</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Mazza</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Boscolo</LastName>
<ForeName>V</ForeName>
<Initials>V</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Rossetti</LastName>
<ForeName>G</ForeName>
<Initials>G</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Marczynska</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Dobosz</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Oldakowska</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Popielska</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Kaflik</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Stanczak</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Stanczack</LastName>
<ForeName>G</ForeName>
<Initials>G</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Dyda</LastName>
<ForeName>T</ForeName>
<Initials>T</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Kruk</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>González Tomé</LastName>
<ForeName>M I</ForeName>
<Initials>MI</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Rojo Conejo</LastName>
<ForeName>P</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Delgado García</LastName>
<ForeName>R</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Fernandez Gonzalez</LastName>
<ForeName>M T</ForeName>
<Initials>MT</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Medin</LastName>
<ForeName>G</ForeName>
<Initials>G</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Mellado Peña</LastName>
<ForeName>M José</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Martín Fontelos</LastName>
<ForeName>P</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Garcia Mellado</LastName>
<ForeName>M I</ForeName>
<Initials>MI</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Medina</LastName>
<ForeName>A F</ForeName>
<Initials>AF</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ascencion</LastName>
<ForeName>B</ForeName>
<Initials>B</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ramos Amador</LastName>
<ForeName>J T</ForeName>
<Initials>JT</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Garcia Bermejo</LastName>
<ForeName>I</ForeName>
<Initials>I</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Navarro Gomez</LastName>
<ForeName>D M L</ForeName>
<Initials>DM</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Saavedra</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Prieto</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Jimenez</LastName>
<ForeName>J L</ForeName>
<Initials>JL</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Muñoz-Fernandez</LastName>
<ForeName>M A</ForeName>
<Initials>MA</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Garcia Torre</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>de José Gómez</LastName>
<ForeName>M I</ForeName>
<Initials>MI</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>García Rodriguez</LastName>
<ForeName>M C</ForeName>
<Initials>MC</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Moreno Pérez</LastName>
<ForeName>D</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Núñez Cuadros</LastName>
<ForeName>E</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Asensi-Botet</LastName>
<ForeName>F</ForeName>
<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Otero Reigada</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
</Investigator>
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