Obesity Impairs the Action of the Neuroendocrine Ghrelin System.
Identifieur interne : 001972 ( PubMed/Checkpoint ); précédent : 001971; suivant : 001973Obesity Impairs the Action of the Neuroendocrine Ghrelin System.
Auteurs : Jeffrey M. Zigman [États-Unis] ; Sebastien G. Bouret [France] ; Zane B. Andrews [Australie]Source :
- Trends in endocrinology and metabolism: TEM [ 1879-3061 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- métabolisme : Ghréline, Obésité.
- physiologie : Métabolisme énergétique, Poids du corps.
- physiopathologie : Obésité.
- Animaux, Humains.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Ghrelin.
- metabolism : Obesity.
- physiology : Body Weight, Energy Metabolism.
- physiopathology : Obesity.
- Animals, Humans.
Abstract
Ghrelin is a metabolic hormone that promotes energy conservation by regulating appetite and energy expenditure. Although some studies suggest that antagonizing ghrelin function attenuates body weight gain and glucose intolerance on a high calorie diet, there is little information about the metabolic actions of ghrelin in the obese state. In this review, we discuss the novel concept of obesity-induced central ghrelin resistance in neural circuits regulating behavior, and impaired ghrelin secretion from the stomach. Interestingly, weight loss restores ghrelin secretion and function, and we hypothesize that ghrelin resistance is a mechanism designed to protect a higher body weight set-point established during times of food availability, to maximize energy reserves during a time of food scarcity.
DOI: 10.1016/j.tem.2015.09.010
PubMed: 26542050
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:26542050Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Obesity Impairs the Action of the Neuroendocrine Ghrelin System.</title><author><name sortKey="Zigman, Jeffrey M" sort="Zigman, Jeffrey M" uniqKey="Zigman J" first="Jeffrey M" last="Zigman">Jeffrey M. Zigman</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Internal Medicine (Divisions of Hypothalamic Research and Endocrinology and Metabolism) and Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX, 75390-9077, USA. Electronic address: Jeffrey.Zigman@UTSouthwestern.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Internal Medicine (Divisions of Hypothalamic Research and Endocrinology and Metabolism) and Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX, 75390-9077</wicri:regionArea><wicri:noRegion>75390-9077</wicri:noRegion></affiliation></author><author><name sortKey="Bouret, Sebastien G" sort="Bouret, Sebastien G" uniqKey="Bouret S" first="Sebastien G" last="Bouret">Sebastien G. Bouret</name><affiliation wicri:level="4"><nlm:affiliation>The Saban Research Institute, Developmental Neuroscience Program, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA 90027, USA; Inserm, Jean-Pierre Aubert Research Center, U1172, University Lille 2, Lille, 59045, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>The Saban Research Institute, Developmental Neuroscience Program, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA 90027, USA; Inserm, Jean-Pierre Aubert Research Center, U1172, University Lille 2, Lille, 59045</wicri:regionArea><wicri:noRegion>59045</wicri:noRegion><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Andrews, Zane B" sort="Andrews, Zane B" uniqKey="Andrews Z" first="Zane B" last="Andrews">Zane B. Andrews</name><affiliation wicri:level="1"><nlm:affiliation>Metabolic Disease and Obesity Theme, Biomedicine Discovery Institute, Department of Physiology, Monash University, Clayton, Victoria 3183, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Metabolic Disease and Obesity Theme, Biomedicine Discovery Institute, Department of Physiology, Monash University, Clayton, Victoria 3183</wicri:regionArea><wicri:noRegion>Victoria 3183</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26542050</idno><idno type="pmid">26542050</idno><idno type="doi">10.1016/j.tem.2015.09.010</idno><idno type="wicri:Area/PubMed/Corpus">002411</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002411</idno><idno type="wicri:Area/PubMed/Curation">002365</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002365</idno><idno type="wicri:Area/PubMed/Checkpoint">002365</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002365</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Obesity Impairs the Action of the Neuroendocrine Ghrelin System.</title><author><name sortKey="Zigman, Jeffrey M" sort="Zigman, Jeffrey M" uniqKey="Zigman J" first="Jeffrey M" last="Zigman">Jeffrey M. Zigman</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Internal Medicine (Divisions of Hypothalamic Research and Endocrinology and Metabolism) and Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX, 75390-9077, USA. Electronic address: Jeffrey.Zigman@UTSouthwestern.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Internal Medicine (Divisions of Hypothalamic Research and Endocrinology and Metabolism) and Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX, 75390-9077</wicri:regionArea><wicri:noRegion>75390-9077</wicri:noRegion></affiliation></author><author><name sortKey="Bouret, Sebastien G" sort="Bouret, Sebastien G" uniqKey="Bouret S" first="Sebastien G" last="Bouret">Sebastien G. Bouret</name><affiliation wicri:level="4"><nlm:affiliation>The Saban Research Institute, Developmental Neuroscience Program, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA 90027, USA; Inserm, Jean-Pierre Aubert Research Center, U1172, University Lille 2, Lille, 59045, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>The Saban Research Institute, Developmental Neuroscience Program, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA 90027, USA; Inserm, Jean-Pierre Aubert Research Center, U1172, University Lille 2, Lille, 59045</wicri:regionArea><wicri:noRegion>59045</wicri:noRegion><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Andrews, Zane B" sort="Andrews, Zane B" uniqKey="Andrews Z" first="Zane B" last="Andrews">Zane B. Andrews</name><affiliation wicri:level="1"><nlm:affiliation>Metabolic Disease and Obesity Theme, Biomedicine Discovery Institute, Department of Physiology, Monash University, Clayton, Victoria 3183, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Metabolic Disease and Obesity Theme, Biomedicine Discovery Institute, Department of Physiology, Monash University, Clayton, Victoria 3183</wicri:regionArea><wicri:noRegion>Victoria 3183</wicri:noRegion></affiliation></author></analytic><series><title level="j">Trends in endocrinology and metabolism: TEM</title><idno type="eISSN">1879-3061</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Body Weight (physiology)</term><term>Energy Metabolism (physiology)</term><term>Ghrelin (metabolism)</term><term>Humans</term><term>Obesity (metabolism)</term><term>Obesity (physiopathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Ghréline (métabolisme)</term><term>Humains</term><term>Métabolisme énergétique (physiologie)</term><term>Obésité (métabolisme)</term><term>Obésité (physiopathologie)</term><term>Poids du corps (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Ghrelin</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Obesity</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Ghréline</term><term>Obésité</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Métabolisme énergétique</term><term>Poids du corps</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Body Weight</term><term>Energy Metabolism</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Obésité</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Obesity</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Ghrelin is a metabolic hormone that promotes energy conservation by regulating appetite and energy expenditure. Although some studies suggest that antagonizing ghrelin function attenuates body weight gain and glucose intolerance on a high calorie diet, there is little information about the metabolic actions of ghrelin in the obese state. In this review, we discuss the novel concept of obesity-induced central ghrelin resistance in neural circuits regulating behavior, and impaired ghrelin secretion from the stomach. Interestingly, weight loss restores ghrelin secretion and function, and we hypothesize that ghrelin resistance is a mechanism designed to protect a higher body weight set-point established during times of food availability, to maximize energy reserves during a time of food scarcity.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26542050</PMID><DateCreated><Year>2016</Year><Month>01</Month><Day>03</Day></DateCreated><DateCompleted><Year>2016</Year><Month>09</Month><Day>30</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-3061</ISSN><JournalIssue CitedMedium="Internet"><Volume>27</Volume><Issue>1</Issue><PubDate><Year>2016</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Trends in endocrinology and metabolism: TEM</Title><ISOAbbreviation>Trends Endocrinol. Metab.</ISOAbbreviation></Journal><ArticleTitle>Obesity Impairs the Action of the Neuroendocrine Ghrelin System.</ArticleTitle><Pagination><MedlinePgn>54-63</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.tem.2015.09.010</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1043-2760(15)00193-9</ELocationID><Abstract><AbstractText>Ghrelin is a metabolic hormone that promotes energy conservation by regulating appetite and energy expenditure. Although some studies suggest that antagonizing ghrelin function attenuates body weight gain and glucose intolerance on a high calorie diet, there is little information about the metabolic actions of ghrelin in the obese state. In this review, we discuss the novel concept of obesity-induced central ghrelin resistance in neural circuits regulating behavior, and impaired ghrelin secretion from the stomach. Interestingly, weight loss restores ghrelin secretion and function, and we hypothesize that ghrelin resistance is a mechanism designed to protect a higher body weight set-point established during times of food availability, to maximize energy reserves during a time of food scarcity.</AbstractText><CopyrightInformation>Copyright © 2015 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zigman</LastName><ForeName>Jeffrey M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Departments of Internal Medicine (Divisions of Hypothalamic Research and Endocrinology and Metabolism) and Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX, 75390-9077, USA. Electronic address: Jeffrey.Zigman@UTSouthwestern.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bouret</LastName><ForeName>Sebastien G</ForeName><Initials>SG</Initials><AffiliationInfo><Affiliation>The Saban Research Institute, Developmental Neuroscience Program, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA 90027, USA; Inserm, Jean-Pierre Aubert Research Center, U1172, University Lille 2, Lille, 59045, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Andrews</LastName><ForeName>Zane B</ForeName><Initials>ZB</Initials><AffiliationInfo><Affiliation>Metabolic Disease and Obesity Theme, Biomedicine Discovery Institute, Department of Physiology, Monash University, Clayton, Victoria 3183, Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>DK84142</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>DK102780</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 DK103884</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 DK084142</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01DK103884</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 DK102780</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>11</Month><Day>02</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Trends Endocrinol Metab</MedlineTA><NlmUniqueID>9001516</NlmUniqueID><ISSNLinking>1043-2760</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D054439">Ghrelin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Cell Metab. 2007 Jun;5(6):438-49</RefSource><PMID Version="1">17550779</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biol Psychiatry. 2010 May 1;67(9):880-6</RefSource><PMID Version="1">20034618</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Endocrinology. 1992 Jun;130(6):3608-16</RefSource><PMID Version="1">1597158</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7467-72</RefSource><PMID Version="1">20231469</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Regul Pept. 2009 Jun 5;155(1-3):91-8</RefSource><PMID Version="1">19361544</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Neurosci. 2008 Jul;11(7):752-3</RefSource><PMID Version="1">18552842</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biol Psychiatry. 2012 Sep 15;72(6):457-65</RefSource><PMID Version="1">22521145</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Comp Neurol. 2012 Feb 1;520(2):281-94</RefSource><PMID Version="1">21674492</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Endocrinology. 2010 Jun;151(6):2940-5</RefSource><PMID Version="1">20375182</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Neurosci. 2006 Jul;9(7):901-6</RefSource><PMID Version="1">16783365</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>FASEB J. 2013 Apr;27(4):1690-700</RefSource><PMID Version="1">23299855</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Horm Behav. 2007 Dec;52(5):612-20</RefSource><PMID Version="1">17826779</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neuroendocrinol. 2015 Jun;27(6):424-34</RefSource><PMID Version="1">25377898</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Endocrinology. 2007 May;148(5):2251-63</RefSource><PMID Version="1">17303662</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1512-7</RefSource><PMID Version="1">23297228</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Endocrinol Metab. 2004 Jun;89(6):2659-64</RefSource><PMID Version="1">15181038</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neuroendocrinol. 2008 Mar;20(3):330-4</RefSource><PMID Version="1">18194428</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain Res. 2006 Sep 27;1112(1):169-78</RefSource><PMID Version="1">16925984</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Endocrinology. 2015 Mar;156(3):858-68</RefSource><PMID Version="1">25535832</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 1999 Dec 9;402(6762):656-60</RefSource><PMID Version="1">10604470</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Peptides. 2008 Nov;29(11):2061-5</RefSource><PMID Version="1">18682266</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Invest. 2015 Feb;125(2):846-58</RefSource><PMID Version="1">25607843</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Metab. 2013 Sep 04;2(4):376-92</RefSource><PMID Version="1">24327954</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Invest. 2011 Jul;121(7):2684-92</RefSource><PMID Version="1">21701068</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Invest. 2006 Dec;116(12):3229-39</RefSource><PMID Version="1">17060947</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Gastroenterology. 2010 Jun;138(7):2468-76, 2476.e1</RefSource><PMID Version="1">20178795</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Physiol Endocrinol Metab. 2012 May 1;302(10):E1300-10</RefSource><PMID Version="1">22414807</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Regul Pept. 2007 Oct 4;143(1-3):118-26</RefSource><PMID Version="1">17573135</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6320-5</RefSource><PMID Version="1">18443287</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Metab. 2014 Aug 01;3(7):717-30</RefSource><PMID Version="1">25353000</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Psychopharmacology (Berl). 2012 Mar;220(1):173-81</RefSource><PMID Version="1">21892647</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Peptides. 2011 Nov;32(11):2362-6</RefSource><PMID Version="1">21736909</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuroendocrinology. 2011;93(1):48-57</RefSource><PMID Version="1">21124019</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2012 May 25;287(22):17942-50</RefSource><PMID Version="1">22474325</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int J Obes Relat Metab Disord. 2004 Jul;28(7):879-85</RefSource><PMID Version="1">15111983</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Invest. 2012 Jan;122(1):153-62</RefSource><PMID Version="1">22201683</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Endocrinol Metab. 2002 Jun;87(6):2984</RefSource><PMID Version="1">12050284</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Endocrinology. 2015 Jan;156(1):280-90</RefSource><PMID Version="1">25322462</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biol Psychiatry. 2012 Sep 1;72(5):347-53</RefSource><PMID Version="1">22458951</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Endocrinology. 2012 Aug;153(8):3646-56</RefSource><PMID Version="1">22691550</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Science. 1996 Aug 16;273(5277):974-7</RefSource><PMID Version="1">8688086</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Endocrinology. 2014 Jul;155(7):2411-22</RefSource><PMID Version="1">24742194</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Diabetes. 2001 Apr;50(4):707-9</RefSource><PMID Version="1">11289032</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nutr Res. 2010 Mar;30(3):163-70</RefSource><PMID Version="1">20417876</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Neurosci. 2012 Aug;15(8):1108-10</RefSource><PMID Version="1">22729177</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Endocrinol Metab. 2008 May;93(5):1971-9</RefSource><PMID Version="1">18198223</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Endocrinol Invest. 2010 Oct;33(9):599-602</RefSource><PMID Version="1">21099246</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Physiol Behav. 2007 Jan 30;90(1):180-5</RefSource><PMID Version="1">17078977</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15868-73</RefSource><PMID Version="1">20713709</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Surg Laparosc Endosc Percutan Tech. 2014 Apr;24(2):122-6</RefSource><PMID Version="1">24686346</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neuroendocrinol. 2011 Jul;23(7):620-6</RefSource><PMID Version="1">21518036</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Peptides. 2011 Nov;32(11):2248-55</RefSource><PMID Version="1">21619904</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Obes Surg. 2011 Jan;21(1):125-30</RefSource><PMID Version="1">21104455</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell. 2008 Feb 8;132(3):387-96</RefSource><PMID Version="1">18267071</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Invest. 2011 Apr;121(4):1424-8</RefSource><PMID Version="1">21364278</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell Metab. 2014 Jul 1;20(1):54-60</RefSource><PMID Version="1">24836560</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Metab. 2015 Mar 21;4(6):437-60</RefSource><PMID Version="1">26042199</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Science. 2010 Dec 17;330(6011):1689-92</RefSource><PMID Version="1">21097901</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int J Obes Relat Metab Disord. 2004 Jul;28(7):886-93</RefSource><PMID Version="1">15148507</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2011 Apr 13;31(15):5841-6</RefSource><PMID Version="1">21490225</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2011 Oct 27;365(17):1597-604</RefSource><PMID Version="1">22029981</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2008 Aug 14;454(7206):846-51</RefSource><PMID Version="1">18668043</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Physiol Behav. 2006 Aug 30;89(1):71-84</RefSource><PMID Version="1">16859720</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Endocrinology. 2010 Oct;151(10):4745-55</RefSource><PMID Version="1">20826561</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Invest. 2005 Dec;115(12):3564-72</RefSource><PMID Version="1">16322794</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Metab. 2014 Oct 24;4(1):15-24</RefSource><PMID Version="1">25685686</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Physiol Gastrointest Liver Physiol. 2012 Aug 1;303(3):G367-76</RefSource><PMID Version="1">22678998</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Endocrinol (Oxf). 2002 Feb;56(2):203-6</RefSource><PMID Version="1">11874411</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Endocrinol Invest. 2007 Oct;30(9):RC22-5</RefSource><PMID Version="1">17993760</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Endocrinology. 2011 Jul;152(7):2619-25</RefSource><PMID Version="1">21521750</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Neurosci. 2006 Mar;9(3):381-8</RefSource><PMID Version="1">16491079</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2001 Jan 11;409(6817):194-8</RefSource><PMID Version="1">11196643</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Psychoneuroendocrinology. 2015 Dec;62:114-20</RefSource><PMID Version="1">26292268</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13226-31</RefSource><PMID Version="1">16891413</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Endocrinol Metab. 2009 Jul;94(7):2290-8</RefSource><PMID Version="1">19401375</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuroscience. 2011 Apr 28;180:129-37</RefSource><PMID Version="1">21335062</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Endocrinol Invest. 2001 Jun;24(6):RC19-21</RefSource><PMID Version="1">11434675</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Diabetes. 2002 Dec;51(12):3412-9</RefSource><PMID Version="1">12453894</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Endocrinol. 2015 Jul;226(1):81-92</RefSource><PMID Version="1">26016745</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Endocrinology. 2013 Feb;154(2):709-17</RefSource><PMID Version="1">23307790</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001835" MajorTopicYN="N">Body Weight</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004734" MajorTopicYN="N">Energy Metabolism</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D054439" MajorTopicYN="N">Ghrelin</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009765" MajorTopicYN="N">Obesity</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">NIHMS769029</OtherID><OtherID Source="NLM">PMC4814209</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>08</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>09</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>09</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>11</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>11</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>10</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26542050</ArticleId><ArticleId IdType="pii">S1043-2760(15)00193-9</ArticleId><ArticleId IdType="doi">10.1016/j.tem.2015.09.010</ArticleId><ArticleId IdType="pmc">PMC4814209</ArticleId><ArticleId IdType="mid">NIHMS769029</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>France</li><li>États-Unis</li></country><region><li>Californie</li></region><settlement><li>Los Angeles</li></settlement><orgName><li>Université de Californie du Sud</li></orgName></list><tree><country name="États-Unis"><noRegion><name sortKey="Zigman, Jeffrey M" sort="Zigman, Jeffrey M" uniqKey="Zigman J" first="Jeffrey M" last="Zigman">Jeffrey M. Zigman</name></noRegion></country><country name="France"><region name="Californie"><name sortKey="Bouret, Sebastien G" sort="Bouret, Sebastien G" uniqKey="Bouret S" first="Sebastien G" last="Bouret">Sebastien G. Bouret</name></region></country><country name="Australie"><noRegion><name sortKey="Andrews, Zane B" sort="Andrews, Zane B" uniqKey="Andrews Z" first="Zane B" last="Andrews">Zane B. Andrews</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001972 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 001972 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= PubMed
|étape= Checkpoint
|type= RBID
|clé= pubmed:26542050
|texte= Obesity Impairs the Action of the Neuroendocrine Ghrelin System.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:26542050" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |